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Predicting non-response to ketamine for depression: an exploratory symptom-level analysis of real-world data among military veterans Psychiatry Res. (IF 11.3) Pub Date : 2024-03-11 Eric A. Miller, Houtan Totonchi Afshar, Jyoti Mishra PhD, Roger S. McIntyre, Dhakshin Ramanathan
Ketamine helps some patients with treatment resistant depression (TRD), but reliable methods for predicting which patients will, or will not, respond to treatment are lacking. Herein, we aim to inform prediction models of non-response to ketamine/esketamine in adults with TRD. This is a retrospective analysis of PHQ-9 item response data from 120 patients with TRD who received repeated doses of intravenous
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Risk of Suicide Attempts and Intentional Self-Harm on Alprazolam Psychiatry Res. (IF 11.3) Pub Date : 2024-03-11 Robert D Gibbons, Kwan Hur, Jill E Lavigne, J. John Mann
From 2000-2021, U.S. suicide deaths have risen 36%. Identification of pharmacological agents associated with increased suicide risk and safer alternatives may help reduce this trend. An exposure-only within-subject time-to-event pharmacoepidemiologic study of the dynamic association between alprazolam treatment and suicide attempts over 2-years. Parallel analyses were conducted for diazepam, lorazepam
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Social Determinants of Mental Health in Major Depressive Disorder: Umbrella Review of 26 Meta-analyses and Systematic Reviews Psychiatry Res. (IF 11.3) Pub Date : 2024-03-11 Noy Alon, Natalia Macrynikola, Dylan J. Jester, Matcheri Keshavan, III Charles F. Reynolds, Shekhar Saxena, Michael L. Thomas, John Torous, Dilip V. Jeste
There is a growing recognition of the impact of social determinants of mental health (SDoMHs) on people with, or at risk of, developing serious mental illnesses. Yet it is not known how associations of individual SDoMHs with risk for major depressive disorder (MDD) vary and roughly compare with one another. Following PRISMA guidelines, this umbrella review included 26 meta-analyses and systematic reviews
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Employing Graph Attention Networks to Decode Psycho-Metabolic Interactions in Schizophrenia Psychiatry Res. (IF 11.3) Pub Date : 2024-03-11 Hongyi Yang, Dian Zhu, YanLi Liu, Zhiqi Xu, Zhao Liu, Weibo Zhang, Jun Cai
Schizophrenia is a severe mental disorder characterized by intricate and underexplored interactions between psychological symptoms and metabolic health, presenting challenges in understanding the disease mechanisms and designing effective treatment strategies. To delve deeply into the complex interactions between mental and metabolic health in patients with schizophrenia, this study constructed a psycho-metabolic
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Non-fatal self-harm and suicide following postpartum psychiatric emergency department visits: A population-based retrospective cohort study Psychiatry Res. (IF 11.3) Pub Date : 2024-03-11 Lucy C. Barker, Hilary K. Brown, Susan E. Bronskill, Kinwah Fung, Paul Kurdyak, Juveria Zaheer, Simone N. Vigod
In a population-based cohort of postpartum individuals in Ontario, Canada, this study aimed to determine the risk of non-fatal self-harm and suicide within one year of an initial postpartum psychiatric emergency department (ED) visit (2008–2020), and the key associated factors. Of 16,475 postpartum individuals with psychiatric ED visits, 714 (4.3 %) had non-fatal self-harm within one year, and 23 (0
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Burnout and depression in college students Psychiatry Res. (IF 11.3) Pub Date : 2024-03-08 Xianyang Wang, Mengyuan Yang, Lei Ren, Qingyi Wang, Shuyi Liang, Yahong Li, Yu Li, Qingchen Zhan, Shen Huang, Kangning Xie, Jianjun Liu, Xinhong Li, Shengjun Wu
Research on burnout has garnered considerable attention since its inception. However, the ongoing debate persists regarding the conceptual model of burnout and its relationship with depression. Thus, we conducted a network analysis to determine the dimensional structure of burnout and the burnout-depression overlap. The Maslach Burnout Inventory-Student Survey and Patient Health Questionnaire-9 were
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Obesity in Latinx and White U.S. military veterans: Mental health, psychosocial burden, non-suicidal self-injury and suicidal behavior Psychiatry Res. (IF 11.3) Pub Date : 2024-03-08 Elina A. Stefanovics, Carlos M. Grilo, Marc N. Potenza, Robert H. Pietrzak
Obesity disproportionately affects Latinx communities and is linked to an increased risk of mental health problems. Military veterans are more likely to develop mental health problems, but the role of Latinx ethnicity in moderating the association between obesity and these problems is unclear. To address this gap, this study examined psychiatric and psychosocial correlates of obesity in a nationally
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Development, validation and clinical utility of Short-term AdVerse-effects of Electroconvulsive therapy (SAVE) Checklist Psychiatry Res. (IF 11.3) Pub Date : 2024-03-07 Chithra Uppinkudru, Harsh Pathak, Raj Kumar K, S Bridgit, Kiran Bagali, Makarand Pantoji, Nathiya Ezhumalai, Rujuta Parlikar, Vyoma Shah, Srinivas Balachander, Vanteemar S Sreeraj, Urvakhsh Meherwan Mehta, Preeti Sinha, Shyam Sundar Arumugham, Ganesan Venkatasubramanian, Jagadisha Thirthalli
Electroconvulsive therapy (ECT) is one of the most effective treatments in psychiatry. However, it has many cognitive and non-cognitive adverse effects (AEs). There are lacunae in the systematic literature on non-cognitive AEs that need a standard, comprehensive and specific clinical tool to evaluate this. Hence, a checklist of short-term AEs of ECT (SAVE) with a 2-phase assessment was developed. Content
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Clinical efficacy of adjunctive esketamine anesthesia in electroconvulsive therapy for major depressive disorders: A pragmatic, randomized, controlled trial Psychiatry Res. (IF 11.3) Pub Date : 2024-03-06 Li Ren, Qibin Chen, Jin Gao, Yuanyuan Liu, Yi Tao, Xiao Li, Qinghua Luo, Feng Lv, Su Min
Electroconvulsive therapy (ECT) is an effective treatment for depression, and esketamine has been shown to have antidepressant effects. However, it is currently unclear whether adjunctive esketamine can enhance the clinical efficacy of ECT in real-world clinical practice. In this pragmatic clinical trial, patients with major depression were randomly assigned into two groups: patients received 0.25
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Using transcranial alternating current stimulation to enhance working memory skills in youths with 22q11.2 deletion syndrome: A randomized double-blind sham-controlled study Psychiatry Res. (IF 11.3) Pub Date : 2024-03-06 Caren Latrèche, Valentina Mancini, Vincent Rochas, Johanna Maeder, Lucia M. Cantonas, Victor Férat, Maude Schneider, Christoph M. Michel, Stephan Eliez
Abnormal cognitive development, particularly working memory (WM) deficits, is among the first apparent manifestations of psychosis. Yet, cognitive impairment only shows limited response to current pharmacological treatment. Alternative interventions to target cognition are highly needed in individuals at high risk for psychosis, like carriers of 22q11.2 deletion syndrome (22q11.2DS). Here we applied
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Mapping prodromal symptoms in patients with bipolar disorder: A network perspective Psychiatry Res. (IF 11.3) Pub Date : 2024-03-05 Yuan Yang, Tong Guo, Qian Zhao, Yang Li, Teris Cheung, Lei Zhang, Xuequan Zhu, Todd Jackson, Xiao-Hong Li, Yu-Tao Xiang
Bipolar disorder (BD) is a major mental disorder that significantly impairs behavior and social functioning. This study assessed the network structure of prodromal symptoms in patients with BD prior to their index mood episode. Semi-structured interviews were conducted with the Bipolar Prodrome Symptom Scale-Retrospective (BPSS-R) to examine patients’ prodromal symptoms. Network analysis was conducted
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Alterations in Performance and Discriminating Power of the Death/Suicide Implicit Association Test Across the Lifespan Psychiatry Res. (IF 11.3) Pub Date : 2024-03-04 Donna A. Ruch, Jeffrey A. Bridge, Jaclyn Tissue, Sean P. Madden, Hanga Galfavy, Marianne Gorlyn, Arielle H. Sheftall, Katalin Szanto, John G. Keilp
The Death/Suicide Implicit Association Test (d/s-IAT) has differentiated individuals with prior and prospective suicide attempts in previous studies, however, age effects on test results remains to be explored. A three-site study compared performance on the d/s-IAT among participants aged 16-80 years with depression and prior suicide attempt (=82), with depression and no attempts (=80), and healthy
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Sexual and gender minority stress and clinical symptom severity in psychiatrically hospitalized adolescents Psychiatry Res. (IF 11.3) Pub Date : 2024-03-04 Kirsty A. Clark, Jessica M. Schwartzman, Alexandra H. Bettis
This study examined the role of lifetime and past 30-day experiences of sexual and gender minority (SGM) stress on clinical symptom severity in 286 psychiatrically hospitalized adolescents. Participants completed measures of clinical symptoms, and SGM adolescents ( 176, 61.5 %) reported on minority stress experiences across three domains (i.e., negative expectancies, internalized homonegativity, homonegative
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The prevalence and determinants of PTSD, anxiety, and depression in Ukrainian civilian physicians and paramedics in wartime–An observational cross-sectional study six months after outbreak Psychiatry Res. (IF 11.3) Pub Date : 2024-03-03 Patryk Rzońca, Marcin Podgórski, Magdalena Łazarewicz, Robert Gałązkowski, Ewa Rzońca, Oryna Detsyk, Dorota Włodarczyk
Russia's invasion of Ukraine is the largest European land offensive since World War II. Individuals affected by conflicts such as war are at an increased risk of mental disorders, which result from frequent exposure to traumatic events and the breakdown of supportive social networks. The aim of the study was to assess the prevalence and determinants of PTSD, anxiety, and depression in Ukrainian civilian
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Serum lipids as predictive markers for death by suicide Psychiatry Res. (IF 11.3) Pub Date : 2024-03-03 C. Hyung Keun Park, Daewook Kim, Bora Kim, Sang Jin Rhee, Sung Joon Cho, Yong Min Ahn
Serum lipid levels have been associated with an increased risk of suicidal behaviors. This retrospective cohort study aimed to investigate the association between serum lipid levels and death by suicide among suicide attempters according to sex. Suicide attempters visiting emergency departments between 2007 and 2011 were followed up until the date of all-cause death or December 31, 2012. Sex-stratified
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Exposure to potentially lethal weapons and drugs among U.S. adolescents with recent depressive symptoms or suicidality in the Adolescent Behaviors and Experiences Survey Psychiatry Res. (IF 11.3) Pub Date : 2024-03-02 Joel Hudgins, Cordelia Mannix, Rebekah Mannix
The scope of lethal means exposure (i.e. guns, intravenous drugs, prescription drugs) relative to depressive symptoms and suicidality in adolescents is not well described. Using the Adolescent Behaviors and Experiences Survey (ABES), we found lethal means exposure increased in a dose dependent manner with increasing depressive symptoms, adjusting for age, sex, race, and ethnicity. Adolescent males
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Adverse childhood experiences and subsequent physical and mental health among young adults: Results from six universities in China Psychiatry Res. (IF 11.3) Pub Date : 2024-03-01 Zheng Zhang, Wenhua Wang, Xiaoxiao Yuan, Xue Wang, Yi Luo, Linfei Dou, Lei Zhang, Mingyang Wu
Research has shown that individuals with adverse childhood experiences (ACEs) are more likely to encounter heightened risks of physical and psychological challenges later in life. However, limited research has explored the comprehensive impact on the physical and mental health of young adults. Thus, we conducted a study to investigate the associations of ACEs with the physical and mental health of
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Association of clinical characteristics, depression remission and suicide risk with discrepancies between self- and clinician-rated suicidal ideation: Two large naturalistic cohorts of outpatients with depression Psychiatry Res. (IF 11.3) Pub Date : 2024-03-01 Bénédicte Nobile, Elia Gourguechon-Buot, Philip Gorwood, Emilie Olié, Philippe Courtet
Clinician- and self-rating of suicidal ideation (SI) are often discrepant. The aim of this study was to determine: 1) Association between discrepant self- and clinician-rated SI with clinical characteristics, depression remission and SA (SA) risk; 2) which SI assessment (self or clinician) predicted depression remission and risk of SA.
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Immersive virtual reality in the treatment of auditory hallucinations: A PRISMA scoping review Psychiatry Res. (IF 11.3) Pub Date : 2024-03-01 Lisa Charlotte Smith, Ana Collados Mateos, Anne Sofie Due, Joanna Bergström, Merete Nordentoft, Lars Clemmensen, Louise Birkedal Glenthøj
A large group of psychiatric patients suffer from auditory hallucinations (AH) despite relevant treatment regimens. In mental health populations, AH tend to be verbal (AVH) and the content critical or abusive. Trials employing immersive virtual reality (VR) to treat mental health disorders are emerging. The aim of this scoping review is to provide an overview of clinical trials utilizing VR in the
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Predictors of remission after repetitive transcranial magnetic stimulation for the treatment of late-life depression Psychiatry Res. (IF 11.3) Pub Date : 2024-02-29 Katharina Göke, Alisson P. Trevizol, Clement Ma, Linda Mah, Tarek K. Rajji, Zafiris J. Daskalakis, Jonathan Downar, Shawn M. McClintock, Sean M. Nestor, Yoshihiro Noda, Benoit H. Mulsant, Daniel M. Blumberger
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment in patients with depression, yet treatment response remains variable. While previous work has identified predictors of remission in younger adults, relatively little data exists in late-life depression (LLD). To address this gap, data from 164 participants with LLD from a randomized non-inferiority treatment trial comparing
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Adverse childhood experiences and recent negative events are associated with activated immune and growth factor pathways, the phenome of first episode major depression and suicidal behaviors Psychiatry Res. (IF 11.3) Pub Date : 2024-02-29 Abbas F. Almulla, Ali Abbas Abo Algon, Michael Maes
This research assessed the effects of adverse childhood experiences (ACEs) and negative life events (NLEs) on forty-eight cytokines/chemokines/growth factors, in 71 FE-MDMD patients and forty heathy controls. ACEs are highly significantly associated with the classical M1 macrophage, T helper (Th)-1, Th-1 polarization, IRS, and neurotoxicity immune profiles, and not with the alternative M2, and Th-2
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Change in neurocognitive functioning in patients with treatment-resistant depression with serial intravenous ketamine infusions: The Bio-K multicenter trial Psychiatry Res. (IF 11.3) Pub Date : 2024-02-28 Balwinder Singh, Sagar V. Parikh, Jennifer L. Vande Voort, Vanessa K. Pazdernik, Eric D. Achtyes, Fernando S. Goes, Anastasia K. Yocum, Louis Nykamp, Alexis Becerra, LeAnn Smart, John F. Greden, William V. Bobo, Mark A. Frye, Katherine E. Burdick, Kelly A. Ryan
This nonrandomized, multicenter, open-label clinical trial explored the impact of intravenous (IV) ketamine on cognitive function in adults ( = 74) with treatment-resistant depression (TRD). Patients received three IV ketamine infusions during the acute phase and, if remitted, four additional infusions in the continuation phase (Mayo site). Cognitive assessments using the Repeatable Battery for the
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Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches Psychiatry Res. (IF 11.3) Pub Date : 2024-02-28 Bao-Zhu Yang, Bo Xiang, Tingting Wang, Shuangge Ma, Chiang-Shan R. Li
Our study focused on human brain transcriptomes and the genetic risks of cigarettes per day (CPD) to investigate the neurogenetic mechanisms of individual variation in nicotine use severity. We constructed whole-brain and intramodular region-specific coexpression networks using BrainSpan's transcriptomes, and the genomewide association studies identified risk variants of CPD, confirmed the associations
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A meta-cognitive Wisconsin Card Sorting Test in people with schizophrenia and bipolar disorder: Self-assessment of sorting performance Psychiatry Res. (IF 11.3) Pub Date : 2024-02-27 Mary E. Gorora, Nina Dalkner, Raeanne C. Moore, Colin A. Depp, Varsha D. Badal, Robert A. Ackerman, Amy E. Pinkham, Philip D. Harvey
People with serious mental illness have challenged self-awareness, including momentary monitoring of performance. A core feature of this challenge is in the domain of using external information to guide behavior, an ability that is measured very well by certain problem-solving tasks such as the Wisconsin Card Sorting Test (WCST) . We used a modified WCST to examine correct sorts and accuracy decisions
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Associations of history of alcohol use disorder with loneliness, social support, and mental health during the COVID-19 pandemic Psychiatry Res. (IF 11.3) Pub Date : 2024-02-27 Jeremy W. Luk, Noa Leiter, Bethany L. Stangl, Tommy Gunawan, Melanie L. Schwandt, David Goldman, Nancy Diazgranados, Vijay A. Ramchandani
This study examined the effects of alcohol use disorder (AUD) and treatment history on changes in loneliness, social support, and mental health symptoms from before to during the pandemic, and tested loneliness and social support as mediators of the AUD-mental health associations. Participants ( = 427) enrolled in the NIAAA COVID-19 Pandemic Impact on Alcohol Study were categorized into three groups:
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Substance use disorder and lifetime suicidal behaviour: A scoping review Psychiatry Res. (IF 11.3) Pub Date : 2024-02-27 Leire Leza, Begoña Haro, José J. López-Goñi, Javier Fernández-Montalvo
Suicidal behaviours are prevalent in substance use disorder (SUD) patients. These behaviours have a negative impact on the psychopathological profile of these patients. However, few studies have evaluated suicide as a continuum (i.e. starting with ideation, followed by attempts and ending with death) and its evolution during treatment. The aim of this scoping review was to explore what is known about
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Substance addictions and suicidal thoughts and behaviors: Evidence from a multi-wave epidemiological study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-27 Angela Giugovaz, Michele Grassi, Igor Marchetti
Substance addiction (SA) is a risk factor of suicidal thoughts and behaviors (STB), although it is still unclear which SAs are reliably associated with increased risk for suicidal ideation, planning, and attempt. The current study aimed to meet this goal using data from the National Survey on Drug Use and Health (NSDUH) referring to years from 2008 to 2020. The information extracted included sociodemographic
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The joint effect of mental illness and parental suicide attempt on offspring suicide attempt and death: A Danish nationwide, registry-based study using multistate modeling Psychiatry Res. (IF 11.3) Pub Date : 2024-02-27 Erik Christiansen, Mette Reilev, Christina Petrea Larsen, Niels Bilenberg, Esben Agerbo
The aim of this study was to analyse the joint impact of moderate-to-severe mental illness and parental suicidal attempts on suicidal attempt and premature death. Using the Danish, nationwide health registries, a cohort study was conducted including the birth cohorts 1983-1989. Cox regression and multistate models were used to estimate relative and absolute risks of suicide attempt and premature death
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Suicidality associated with decreased help-seeking attitudes in college students: Implications for identifying and treating at-risk students Psychiatry Res. (IF 11.3) Pub Date : 2024-02-25 Ritika Rastogi, G. Alice Woolverton, Courtney Stevens, Justin A. Chen, Cindy H. Liu
Suicide is a leading cause of death in college-aged youth, yet only half of all college students report engaging in professional mental health help-seeking. We examined how the various aspects of young adults’ suicidality were associated with their openness to pursue professional mental health care in the future (i.e., “future help-seeking intentions”). Multilevel binary logistic regressions were tested
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Explainable multimodal prediction of treatment-resistance in patients with depression leveraging brain morphometry and natural language processing Psychiatry Res. (IF 11.3) Pub Date : 2024-02-25 Dong Yun Lee, Narae Kim, ChulHyoung Park, Sujin Gan, Sang Joon Son, Rae Woong Park, Bumhee Park
Although 20% of patients with depression receiving treatment do not achieve remission, predicting treatment-resistant depression (TRD) remains challenging. In this study, we aimed to develop an explainable multimodal prediction model for TRD using structured electronic medical record data, brain morphometry, and natural language processing. In total, 247 patients with a new depressive episode were
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Prevalence of youth experiencing homelessness and its association with suicidal thoughts and behaviors: Findings from a population-based study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-25 Philip Baiden, Catherine A. LaBrenz, Marisa N. Broni, John F. Baiden, Omolola E. Adepoju
Although various studies have examined factors associated with suicidal behaviors among youth, few studies have investigated the association between youth experiencing homelessness (YEH) and suicidal thoughts and behaviors (STBs) using a large nationally representative sample. The objectives of this study were to investigate prevalence of YEH and its association with STBs. Data for this study came
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Co-occurrence of mental illness and substance use among US pregnant individuals, 2012-2021 Psychiatry Res. (IF 11.3) Pub Date : 2024-02-24 Zhong Li, Curisa M. Tucker, Cassie L. Odahowski, Kacey Y Eichelberger, Jiajia Zhang, Peiyin Hung
Substance use disorders are increasingly prevalent among pregnant individuals, with evident risks of adverse perinatal outcomes. This study examines substance use (tobacco, alcohol and marijuana) among pregnant individuals with mental illness. A national representative sample of pregnant individuals were derived from 2012 to 2021 National Survey of Drug Use and Health data. Associations of past-year
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Development of the complex trauma screener: A brief measure of ICD-11 PTSD and complex PTSD Psychiatry Res. (IF 11.3) Pub Date : 2024-02-24 J.M. Litvin, P.L. Kaminski, A. Ryals
The purpose of this study was to develop the Complex Trauma Screener (CTS), a brief screener (seven items) of the ICD-11 trauma disorders that can be used in “quick-paced” facilities. We examined the factor structure of the CTS in two separate samples: civilian college students (N=823) and military veterans (N=130) who reported exposure to at least one traumatic event. Confirmatory factor analyses
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How different definition criteria may predict clinical outcome in treatment resistant depression: Results from a prospective real-world study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-24 Raffaella Zanardi, Matteo Carminati, Francesco Attanasio, Valentina Fazio, Melania Maccario, Cristina Colombo
Management of treatment-resistant depression (TRD) remains a major public health challenge, also due to the lack of a consensus around TRD definition. We investigated the impact of different definitions of TRD on identifying patients with distinct features in terms of baseline characteristics, treatment strategies, and clinical outcome. We conducted a prospective naturalistic study on 538 depressed
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Mother-to-infant bonding difficulties are associated with future maternal depression and child-maltreatment behaviors: A Japanese nationwide longitudinal study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-24 Chong Chen, Sumiyo Okawa, Ryo Okubo, Kosuke Hagiwara, Tomohiro Mizumoto, Naoko Higuchi, Shin Nakagawa, Takahiro Tabuchi
Mother-to-infant bonding difficulties (MIBD) are considered risk factors for postpartum depression and child-maltreatment behaviors. However, few longitudinal studies have examined this hypothesis. This study aims to explore the relationship between MIBD and subsequent maternal depression and child-maltreatment behaviors using longitudinal data from a 2021 Japanese nationwide survey. We studied 658
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Understanding the subtypes of non-suicidal self-injury: A new conceptual framework based on a systematic review Psychiatry Res. (IF 11.3) Pub Date : 2024-02-24 Zhenhai Wang, Dongjie Li, Yanrong Chen, Zhiyuan Tao, Liyun Jiang, Xu He, Wei Zhang
Non-suicidal self-injury (NSSI) is a significant public health problem, but there is no consistent evidence of its risk factors. One possibility is that there are subtypes NSSI that have different risk factors and clinical symptoms. In this review we evaluated the evidence of subtypes to determine if there were consistent subtypes of NSSI that emerged across studies. Four databases (Medline; Embase;
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Improvements in performance based measures of functional capacity and cognition after computerized functional skills training in older people with mild cognitive impairment and healthy comparators Psychiatry Res. (IF 11.3) Pub Date : 2024-02-23 Philip D. Harvey, Melissa Chirino, Annalee Mueller, Andrea Rivera-Molina, Matthew Zayas-Bazan, Peter Kallestrup, Sara J. Czaja
With no pharmacological treatments for Mild Cognitive impairment (MCI), computerized training strategies have been attempted. A computerized skills training intervention, FUNSAT, previously produced training-related gains in cognition in MCI and in comparators with normal cognition (NC). A new remotely delivered version of FUNSAT was administered to a new sample of participants with NC and MCI. Outcomes
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Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT Psychiatry Res. (IF 11.3) Pub Date : 2024-02-23 Sarah El-Heis, Sheila J. Barton, Hsin Fang Chang, Heidi Nield, Vanessa Cox, Sevasti Galani, Wayne Cutfield, Shiao-Yng Chan, Keith M. Godfrey
Observational studies have reported associations between nutrition during pregnancy and mental wellbeing. As secondary outcomes, the NiPPeR double-blind randomized trial in women planning conception investigated whether a myo-inositol, probiotics and enriched micronutrients formulation (intervention) taken preconception and throughout pregnancy could improve mental wellbeing during pregnancy and post-delivery
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Predicting Autism Spectrum Disorder Using Maternal Risk Factors: A Multi-Center Machine Learning Study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-22 Qiuhong Wei, Yuanjie Xiao, Ting Yang, Jie Chen, Li Chen, Ke Wang, Jie Zhang, Ling Li, Feiyong Jia, Lijie Wu, Yan Hao, Xiaoyan Ke, Mingji Yi, Qi Hong, Jinjin Chen, Shuanfeng Fang, Yichao Wang, Qi Wang, Chunhua Jin, Ximing Xu, Tingyu Li
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a complex environmental etiology involving maternal risk factors, which have been combined with machine learning to predict ASD. However, limited studies have considered the factors throughout preconception, perinatal, and postnatal periods, and even fewer have been conducted in multi-center. In this study, five predictive models
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Self-harm and suicide death in the three years following hospitalization for intentional self-harm in adolescents and young adults: A nationwide study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-22 Karine Goueslard, Catherine Quantin, Fabrice Jollant
Self-harm is frequent in youths. This study aimed to assess the risk of self-harm and mortality over a three-year period following self-harm hospitalization. Data were extracted from national databases in France. All patients aged 12 to 24 years and hospitalized for self-harm in 2013–2014 were included and compared to age- and sex-matched individuals with no self-harm hospitalization during this period
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Effectiveness of mindfulness-based intervention in schizophrenia: A meta-analysis of randomized controlled trials Psychiatry Res. (IF 11.3) Pub Date : 2024-02-21 Keke Qin, Yong Yu, Huiling Cai, Jiahong Li, Jingyuan Zeng, Huolan Liang
Schizophrenia poses significant societal challenges, including interpersonal tension, an increased risk of suicide, and soaring medical costs. Although antipsychotics can prevent relapses, they often give rise to adverse effects and do not provide lasting relief. Mindfulness-based interventions (MBI) emerge as a hopeful avenue for improving outcomes. However, existing research and meta-analyses of
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Strength training has antidepressant effects in people with depression or depressive symptoms but no other severe diseases: a systematic review with meta-analysis Psychiatry Res. (IF 11.3) Pub Date : 2024-02-20 Fabricio Eduardo Rossi, Gustavo Gusmão dos Santos, Priscila Almeida Queiroz Rossi, Brendon Stubbs, Felipe Schuch, Lucas Melo Neves
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Adverse childhood experiences and crime outcomes in early adulthood: A multi-method approach in a Brazilian birth cohort Psychiatry Res. (IF 11.3) Pub Date : 2024-02-19 Andreas Bauer, Rafaela Costa Martins, Gemma Hammerton, Maurício Scopel Hoffmann, Andressa Souza Cardoso, Camila Colvara, Clarissa Fialho Hartmann, Gabriel Calegaro, Luciana Rodrigues Perrone, Nilvia Aurélio, Ana M.B. Menezes, Joseph Murray
This study aimed to investigate alternative approaches to a cumulative risk score in the relationship between adverse childhood experiences (ACEs) and crime. Using data from the 1993 Pelotas (Brazil) Birth Cohort (=3,236), we measured 12 ACEs up to 15 years, and past-year violent and non-violent crime at 22 years. We used four analytical approaches: single adversities, cumulative risk, latent class
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Effect of concomitant use of valproic acid during clozapine initiation on clozapine-induced inflammation among Japanese patients with schizophrenia Psychiatry Res. (IF 11.3) Pub Date : 2024-02-19 Yuki Kikuchi, Hiroshi Komatsu, Yuji Otsuka, Fumiaki Ito, Yuji Yada, Hiroaki Tanifuji, Hiroaki Tomita
During clozapine initiation, titration speed and concomitant valproate administration have been reported as risk factors for clozapine-induced fever and myocarditis. We tested the risk of concomitant valproate administration by stratifying patients according to titration rate. Concomitant valproate use was only associated with increased inflammatory adverse events in the slower titration group. The
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Excess suicides in Japan: a three-year post-pandemic assessment of gender and age disparities Psychiatry Res. (IF 11.3) Pub Date : 2024-02-18 Haruka Sakamoto, Masahide Koda, Akifumi Eguchi, Kaori Endo, Takahiro Arai, Nahoko Harada, Takashi Nishio, Shuhei Nomura
This study offers an in-depth analysis of Japan's suicide trends three years after the COVID-19 outbreak. Using data from the National Police Agency (January 2010-May 2023), we examined suicide rates across genders and age groups. Employing the quasi-Poisson regression, we predicted monthly death counts. Findings indicate a steady rise in female suicides from April 2020 to January 2023. Notably, male
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From Facts to Feelings: Navigating the Complexities of COVID-19 Restrictions, Perceptions, and Mental Well-being Psychiatry Res. (IF 11.3) Pub Date : 2024-02-18 Madeline A. Gregory, Jennifer T.H. Reeves, Alexa Danyluk, Nicole K. Legg, Peter Phiri, Shanaya Rathod, Brianna J. Turner, Theone S.E. Paterson
Objectives of the present study were to 1) examine accuracy of COVID-19 public health restriction knowledge and the impact of information source, 2) assess the effect of level of restriction on perceived infection risk of COVID-19 infection and level of compliance with restrictions, and 3) investigate the relationship between mental health outcomes and as well as level of restriction. Canadians 5,051)
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The effectiveness of a suicide prevention program in primary care clinics supported by community public health resources: A difference-in-differences analysis Psychiatry Res. (IF 11.3) Pub Date : 2024-02-18 Hyunsuk Jeong, Hyeon Woo Yim, Seung-Yup Lee, Misun Park, Woolim Ko
The importance of appropriate and intensive follow-up management for individuals identified with suicide risk through screening is highlighted. The Link between Primary Care Clinic and Public Health Resources Intervention(LinkPC-PH), a suicide prevention program in primary care clinics supported by community public health resources, was implemented at the district level in 2017. The purpose of the
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Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder Psychiatry Res. (IF 11.3) Pub Date : 2024-02-18 Zuoquan Xie, Jingjing Huang, Guangqiang Sun, Shen He, Zhiyu Luo, Linna Zhang, Liang Li, Min Yao, Chen Du, Wenjuan Yu, Yuan Feng, Dabing Yang, Jing Zhang, Changrong Ge, Huafang Li, Meiyu Geng
Major depressive disorder (MDD) involves systemic changes in peripheral blood and gut microbiota, but the current understanding is incomplete. Herein, we conducted a multi-omics analysis of fecal and blood samples obtained from an observational cohort including MDD patients (n=99) and healthy control (HC, n=50). 16S rRNA sequencing of gut microbiota showed structural alterations in MDD, as characterized
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Mental health conditions and utilisation of mental health services by survivors of physical intimate partner violence in portugal: Results from the WHO world mental health survey Psychiatry Res. (IF 11.3) Pub Date : 2024-02-17 Ugnė Grigaitė, Sofia Azeredo-Lopes, Graça Cardoso, Bárbara Pedrosa, Deborah Oyine Aluh, Margarida Santos-Dias, Manuela Silva, Miguel Xavier, José Miguel Caldas-de-Almeida
The aim of this article is to study mental health conditions among survivors of severe physical intimate partner violence (IPV) and their utilisation of mental health services. This study is an integrated part of the World Mental Health Survey Initiative-Portugal, for which data was collected from a nationally representative adult sample using well-validated scales. Logistic regression models were
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Abnormal energy metabolism, oxidative stress, and polyunsaturated fatty acid metabolism in depressed adolescents associated with childhood maltreatment: A targeted metabolite analysis Psychiatry Res. (IF 11.3) Pub Date : 2024-02-16 Hui Chen, Jinfeng Wang, Shurui Chen, Xianliang Chen, Jiali Liu, Huajia Tang, Jiawei Zhou, Yusheng Tian, Xiaoping Wang, Xia Cao, Jiansong Zhou
The purpose of this study was to explore the metabolomic differences between Major depressive disorder (MDD) and healthy individuals among adolescents and the association between childhood maltreatment (CM) and differentially abundant metabolites. The exploratory study included 40 first-episode drug-naïve adolescents with MDD and 20 healthy volunteers. We used the Beck Depression Inventory (BDI-13)
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Health service and psychotropic medication use for mental health conditions among healthcare workers active during the Spain Covid-19 Pandemic – A prospective cohort study using web-based surveys. Psychiatry Res. (IF 11.3) Pub Date : 2024-02-16 Philippe Mortier, Gemma Vilagut, Helena García-Mieres, Itxaso Alayo, Montse Ferrer, Franco Amigo, Enric Aragonès, Andrés Aragón-Peña, Ángel Asúnsolo del Barco, Mireia Campos, Meritxell Espuga, Ana González-Pinto, Josep M Haro, Nieves López Fresneña, Alma D Martínez de Salázar, Juan D Molina, Rafael M Ortí-Lucas, Mara Parellada, José Maria Pelayo-Terán, Beatriz Pérez-Gómez, Aurora Pérez-Zapata, José
Little is known about healthcare workers’ (HCW) use of healthcare services for mental disorders. This study presents data from a 16-month prospective cohort study of Spanish HCW ( = 4,809), recruited shortly after the COVID-19 pandemic onset, and assessed at four timepoints using web-based surveys. Use of health services among HCW with mental health conditions (i.e., those having a positive screen
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Erratum to “Development of the short version of the spielberger state—trait anxiety inventory” [Psychiatry Research Volume 291, September 2020, 113223] Psychiatry Res. (IF 11.3) Pub Date : 2024-02-15 Andras N. Zsido, Szidalisz A. Teleki, Krisztina Csokasi, Sandor Rozsa, Szabolcs A. Bandi
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Gut microbial and clinical characteristics of individuals with autism spectrum disorder differ depending on the ecological structure of the gut microbiome Psychiatry Res. (IF 11.3) Pub Date : 2024-02-14 Yeonjae Jung, Taeyeop Lee, Hyun-Seok Oh, Yerin Hyun, Seungyeon Song, Jongsik Chun, Hyo-Won Kim
Understanding the relationship between the gut microbiome and autism spectrum disorder (ASD) is challenging due to the heterogeneous nature of ASD. Here, we analyzed the microbial and clinical characteristics of individuals with ASD using enterotypes. A total of 456 individuals participated in the study, including 249 participants with ASD, 106 typically developing siblings, and 101 controls. The alpha
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Cardiac and metabolic safety profile of antipsychotics in youths: A WHO safety database analysis Psychiatry Res. (IF 11.3) Pub Date : 2024-02-14 Diane Merino, Alexandre O. Gérard, Alexandre Destere, Haitam Saidessalam, Florence Askenazy, François Montastruc, Milou-Daniel Drici, Susanne Thümmler
A significant heterogeneity prevails in antipsychotics (APs) safety monitoring recommendations. Youths are deemed more vulnerable to cardiometabolic side effects. We aimed to assess age-dependent reporting of cardiac and metabolic disorders in youths, relying on the WHO safety database (VigiBase®). VigiBase® was queried for all reports of cardiac, glucose, lipid and nutritional disorders involving
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Ethnoracialized group differences in attitudes and knowledge about schizophrenia and willingness to engage in biomarker research: The UBIGR Study Psychiatry Res. (IF 11.3) Pub Date : 2024-02-14 Diane Carol Gooding, Denise A. Mohrbacher, Emre Umucu, Carol A. Van Hulle, Jordan P. Lewis, Fabu P. Carter, Carey E. Gleason
Although there is renewed optimism in biomarker research in schizophrenia, there is also need for greater inclusion of historically underrepresented groups in the research. In the present study, we surveyed 599 African American, 352 American Indian/Alaskan Native, and 725 NonHispanic White participants about their attitudes towards research, knowledge and attitudes about schizophrenia, and willingness
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Association between electronic nicotine product use and subsequent first episode psychosis Psychiatry Res. (IF 11.3) Pub Date : 2024-02-13 Andrew S Hyatt, Norah Mulvaney-Day, Clifton M Chow, Benjamin Lê Cook, Lynn E DeLisi
Tobacco use has been established as a possible risk factor for psychosis, but the effect of electronic nicotine delivery systems (ex. nicotine vapes) has not been independently established. Using the Population Assessment of Tobacco and Health study, we found that use of electronic nicotine products was significantly associated with later first episode psychosis after controlling for substance use
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Repetitive negative thinking as a unique transdiagnostic risk factor for suicidal ideation Psychiatry Res. (IF 11.3) Pub Date : 2024-02-13 M.M. Caudle, N.N. Dugas, K. Patel, R.C. Moore, M.L. Thomas, J. Bomyea
Repetitive negative thinking (RNT) is a transdiagnostic symptom observed across mood and anxiety disorders and is characterized by frequent, distressing thoughts that are perceived as uncontrollable. Specific forms of RNT have been linked to increased suicide risk. However, most work examining links between RNT and suicide has been conducted within specific disorders and subtypes of RNT (e.g., rumination
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Functional connectivity and complexity analyses of resting-state fMRI in pre-adolescents demonstrating the behavioral symptoms of ADHD Psychiatry Res. (IF 11.3) Pub Date : 2024-02-13 Ru Zhang, Stuart B. Murray, Christina J. Duval, Danny J.J. Wang, Kay Jann
Attention deficit hyperactivity disorder (ADHD) has been characterized by impairments among distributed functional brain networks, e.g., the frontoparietal network (FPN), default mode network (DMN), reward and motivation-related circuits (RMN), and salience network (SAL). In the current study, we evaluated the complexity and functional connectivity (FC) of resting state fMRI (rsfMRI) in pre-adolescents
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MoodSensing: A Smartphone APP for Digital Phenotyping and Assessment of Bipolar Disorder Psychiatry Res. (IF 11.3) Pub Date : 2024-02-13 Jia-Hao Hsu, Chung-Hsien Wu, Esther Ching-Lan Lin, Po-See Chen
Daily life tracking has proven to be of great help in the assessment of patients with bipolar disorder. Although there are many smartphone apps for tracking bipolar disorder, most of them lack academic verification, privacy policy and long-term maintenance. Our developed app, MoodSensing, aims to collect users' digital phenotyping for assessment of bipolar disorder. The data collection was approved