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Arabic translation, content validity and reliability of the Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 (MSISQ-19) Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-03-13 Ali Ahmed Abou El-Maaty, Saad Shawki El Sherifi, Abdel-Hady El-Gilany, Hamada Ibrahim Zehry, Almaza Ali Salim, Mahmoud F. Rohiem, Ahmed Fawzi Ismael
The prevalence of sexual dysfunction (SD) in multiple sclerosis (MS) patients is accounted to affect nearly 75% of them with higher rate in men than women. Though most of the patients may desire to discuss confidentially the SD with their physician, but both the physician and the patient usually hesitate to break into this presumed taboo. Assuming that MS affects about 35.9 per 100,000 population,
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Sirtuin-1 level and gene polymorphisms in multiple sclerosis Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-03-12 Rania S. Nageeb, Amal Fawzy, Marwa Abdel-Monem Ateya, Aliaa Talaat
Sirtuin-1 (SIRT1) may affect multiple sclerosis (MS) disease. This study aimed to investigate the level of serum SIRT1, mRNA expression and genetic polymorphisms in Egyptian MS sufferers. Also, to assess its role as a possible biomarker in predicting the risk of MS and to evaluate the association between its levels and disability of MS. Measurement of SIRT1, serum level, mRNA expression level and genotyping
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Seroprevalence of toxoplasmosis among children with autism Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-03-08 Shaimaa Helmy El-Sayed, Khaled Abdel Haleim Al-Shewy, Emad Mearouf Abdin, Haytham Mohamad Hasan
Toxoplasmosis is considered one of the most common public health troubles. Among these health troubles, toxoplasmosis was recently linked to many neuropsychiatric and behavioral disorders, especially autism spectrum disorder (ASD). The purpose of this study was to determine the seroprevalence of toxoplasmosis in children with ASD. The study was conducted on 100 children, grouped in two groups; group
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Neurological manifestations in hospitalized COVID-19 patients: a cross-sectional study Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-03-05 Davood Kashipazha, Davood Shalilahmadi, Gholamreza Shamsaei, Nastaran Farahmand Porkar
Accumulating evidence on the neurological sequelae of COVID-19 is a serious concern, with patients possibly being at risk of permanent debilitation if not managed appropriately. We aimed to determine the prevalence and pattern of neurological manifestations and diagnostic and therapeutic findings among hospitalized COVID-19 patients consulted with the neurology service for neurological disorders. We
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Neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as predictors of MS severity: a retrospective cohort study Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-29 Sabah E. Fathy, Amany M. AbdAllah, Rania Y. Helal
Multiple sclerosis (MS) is a disabling immune-mediated disease of the central nervous system. Ministry of Health and Population’s statistics show that MS comprise 1.4% of all neurological diseases, putting into consideration, current economic crisis; it is needed to predict disease severity with an acceptable cost-effective method. Complete blood count (CBC) parameters are supposed to be cheap, and simple
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Potential use of microRNA-590 biomarkers verses plasma calcitonin gene-related peptide for diagnosis of migraine Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-28 Hany Mohamed El Deeb, Rasha Said Amr, Dina Elsayed Gaber
Many biomarkers have been investigated for migraine diagnosis, giving insights into the pathophysiology of migraine, treatment response, and for the development of new treatment strategies. Over the years, many substances, for example, neurotransmitters, neuropeptides, glio transmitters, and hormones, have been suggested as possible biomarkers for migraine. The literature demonstrates that miRNAs may
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Whole exome sequencing in a sample of Egyptian patients with covert cerebral small vessel disease Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-28 Hany Aref, Mohamed Maged, Tamer Roushdy, Hossam Shokri, Eman Hamid, Bernard P. H. Cho, Hugh S. Markus, Mai Fathy, Nevine El Nahas
Covert cerebral small vessel disease (cCSVD) is associated with many age-related morbidities with little available data regarding the pathophysiology and role of genetics in it. This study aims to investigate the genetic load in a sample of Egyptian patients with cCSVD. Thirty patients with cCSVD were recruited and underwent cognitive, gait, sphincter assessment, magnetic resonance imaging (MRI) brain
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Impact of Parkinsonism comorbid depression on cognitive functions Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-28 Ghaydaa A. Shehata, Hassan M. Farweez, Anwar M. Ali, Huda S. Hassan, Amal M. Tohamy, Mohamed Mostafa, Mostafa A. Ibrahim, Khaled Tarek, Asmaa Ahmed Elrashedy, Ramy Abdelnaby, Mohamed Elsayed, Dina Elsayed Gaber
Parkinson's disease (PD) is a chronic progressive neurodegenerative disabling disease and involves about 1–3% of the worldwide population over the age of 60. A significant prevalence of psychopathological symptoms has been recorded as most patients with PD developed over their disease course neuropsychiatric symptoms such as depression, anxiety, sleep disorders, psychosis, and cognitive and behavioral
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The diagnostic yield of a 2-h versus a 30-min electroencephalogram for patients with altered mental status in neurological intensive care unit Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-28 Nesma Mounir, Ehab Shaker Belal, Mahmoud Fathi Abozeina, Aliaa Ali Tawfeek
The continuous electroencephalogram (cEEG) monitoring is recommended for critical ill patients with altered mental status, The cEEG detects seizure activity and nonconvulsive status epilepticus (NCSE) more efficiently than routine electroencephalogram (rEEG). Yet, cEEG is not widely available in many neurological intensive care units (NICU) in limited resource countries. Ideal study duration, and whether
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The future of minimally invasive spine surgery in low-income Latin American countries Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-28 Daniel Encarnacion Santos, Ismail Bozkurt, Renat Nurmukhametov, Medet Dosanov, Alexander Volovish, Gennady Chmutin, Ariel Tapia Sierra, Brenda Eneliz, Edwin Bernard, Phon Nakry, Gianluca Scalia, Bipin Chaurasia
Treatment of spinal disorders can be managed conservatively or surgically. With the trend toward minimalistic approaches, minimally invasive spinal surgery (MISS) has gained much more importance over the last decade. Its use along with the required training has tremendously increased in developed countries. However, the availability of MISS today is uneven in different regions due to the development
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The use of muscle ultrasound to detect critical illness myopathy in patients with sepsis: an observational cohort study Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-26 Mostafa M. Elkholy, Mohammed A. Osman, Ahmed S. Abd El Basset, Sameh K. El Maraghi, Hamdy M. Saber
Critical illness myopathy (CIM) has negative impact on patient outcomes. We aimed to explore the diagnostic value of bedside ultrasonography for early identification of CIM in septic patients and its correlation with other diagnostic methods. This prospective observational study included 40 ICU patients diagnosed with sepsis on admission or within 48 h later according to the third International Consensus
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Right-sided alien hand in acute parietal infarction: a case report Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-26 Nevine El Nahas, Mohamed Maged, Fatma Fathalla Kenawy
Alien limb is an involuntary movement that is considered a diagnostic feature of corticobasal degeneration syndrome. Few reports describe this condition in acute stroke, and most of them result from right parietal infarction. This is a case of acute stroke presenting with a right-sided alien limb that was followed by right-sided weakness and aphasia. Effective management of the stroke was achieved
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Association between acute stroke and COVID-19 infection among patients with acute stroke Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-26 I. A. Yassine, M. M. Hussein, A. O. Hosny, M. A. ElSamahy
Severe acute respiratory syndrome coronavirus 2 (SARS COV 2) infection is associated with multiple neurological complications. Cerebrovascular accidents are considered as one of the common neurological complications associated with corona virus (COVID-19). It may represent the first presentation of the patients of COVID-19 or may occur anytime during the course of the disease. This study included 381
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Effect of functional electrical stimulation of interscapular muscles on trunk performance and balance in post-stroke elderly patients Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-23 Mohammed Youssef Elhamrawy, Wafik Said Bahnasy, Sabah Mohamed Elkady, Mohamed Taha Said
Disability in the upper limb in post-stroke survivors may have a variety of effects, particularly in the elderly, that require planning therapeutic actions to restore function. Thirty-four patients were randomly assigned to the control group (CON) and the Functional Electrical Stimulation (FES) group. For 12 weeks, the CON group received core stabilization exercises (CSEs). The FES group received (FES)
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Focal finger palsy and wrist pain due to cortical infarction: a case report Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-21 Shiyu Hu, Yang Wang, Lijie Ren
Hand knob infarction induced focal weakness of contralateral hand or distal arm, only accounts for less than 1% of all ischemic strokes. To date, there is no case with pain during sleep as the onset symptoms being reported. The atypical symptoms of hand knob infarction might increase the risk of delaying treatment especially in the hyperacute phase of stroke. A 70-year-old man awoke from sleep due
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New-onset seizures misdiagnosed as psychogenic non-epileptic seizures: a case of paraneoplastic limbic encephalitis with primary testicular cancer Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-20 Axel Rivas, Daniel Levine, Cory Nichols, Mckenzie Merritt, Paul Janda, Aroucha Vickers
Behavioral psychiatric symptoms can be the only warning signs of more serious conditions such as paraneoplastic limbic encephalitis. Differentiating between primary psychiatric disorders and paraneoplastic neurological syndromes is crucial as they require distinct treatment approaches. In this case report, we provide an overview of paraneoplastic encephalitis and introduce a unique case that showcases
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Using 6-CIT, P300 encephalography, and pro-inflammation assessments for screening age-related cognitive decline and exploring associated risk factors in Egyptian elderly Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-19 Mai S. Saleh, Asmaa F. Galal, Sara F. Sallam, Noha A. Mowaad, Hala M. Zeidan, Adel Hashish, Hala R. Elhabashy, Ola A. Heikal
The elderly population is suffering from many mental health problems that are aggravated as a matter of age and cognitive decline is a serious one of them. The aim of the present work is to screen the cognitive performance among a sample of Egyptian elderly volunteers and to investigate the associated risk factors. A sample of 88 elderly volunteers from both genders was enrolled in the study according
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Electrophysiological studies versus high-resolution nerve ultrasound in diagnosis of Guillain–Barré syndrome Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-19 Ahmed Abou Hagar, Mohamed Negm, Samer Elshamly, Osama Shehab, Walid Mosallam, Reda Abd El-Razek
Guillain–Barré syndrome (GBS) is polyneuropathy characterized by inflammation and immune-mediated processes that is classified into many subtypes based on electrophysiological and pathological criteria. The diagnosis of GBS can be confirmed using electrophysiological studies. However, electrophysiological studies may be normal when carried out early within 1 week in the course of the disease (Berciano
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Evaluation of smartphone-assisted infrared thermal imaging efficiency in carpal tunnel syndrome Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-19 Kaya Turan, Osman Görkem Muratoğlu, Tuğrul Ergün, Haluk Çabuk
Thermography is an industrial method for surface temperature measurements, and although it is medically safe and non-invasive, its place in daily practice has been limited. With the development of technology, thermal cameras have become more accessible and practical via adaptation to mobile phones. Among patients evaluated with bilateral nerve conduction studies (NCS) for suspected carpal tunnel syndrome
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The reliability and validity of the Timed Up and Go test in patients ongoing or following lumbar spine surgery: a systematic review and meta-analysis Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-19 Fatih Özden
No other systematic review examined the measurement properties of the TUG in LSS. The present systematic review and meta-analysis aimed to investigate the measurement properties of the Timed Up and Go (TUG) in patients with Lumbar Spine Surgery (LSS). A literature search yielded 906 studies [PubMed:71, Web of Science (WoS):80, Scopus:214, ScienceDirect:471 and Cochrane Library:70]. Included 10 studies
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Return-to-work after interlaminar endoscopic sequestrectomy: case series Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-16 Ismail Bozkurt, Cagri Canbolat, Kemal Paksoy, Salim Senturk, Onur Yaman
Considering the epidemiology of single-level lumbar disc herniations (LDH) in the young and active patients, the impact on working capacity is highly relevant. The timing of return-to-work after lumbar surgery through various modalities differs greatly. This may be partly due diverse disparate surgical approaches along with differences in patient and surgeon. The purpose of this paper is to provide
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Bulbar-onset amyotrophic lateral sclerosis in a patient with genetically confirmed Huntington’s disease: a case study Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-16 Ivo Bozovic, Sanja Gluscevic, Ivana Kezic, Vukan Ivanovic, Aleksa Palibrk, Stojan Peric, Ivana Basta, Zorica Stevic
The rationale for this paper is a description of a patient from Southeast Europe with genetically confirmed Huntington’s disease (HD), coexisting with sporadic, bulbar-onset amyotrophic lateral sclerosis (ALS). To the best of our knowledge, the total number of reported cases with confirmed coexistence of HD and ALS is less than 20. Thus, it is an extremely rare condition speculated to be in a range
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Value of MUNE versus compound muscle action potential in assessing motor unit loss in patients with carpal tunnel syndrome Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-14 Safa Dheaa Al-Den Abdul-Muneem, Hussein Ghani Kaddoori
The most prevalent nerve entrapment disorder, known as carpal tunnel syndrome (CTS), is brought on by wrist-based median nerve compression. Focal demyelination progresses to axonal dysfunction as the condition worsens. In order to detect motor unit (MU) loos, this study compares two motor unit number estimation (MUNE) techniques with compound muscle action potential (CMAP) amplitude. The CMAP amplitude
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The effect of transcranial direct current stimulation paired with neuromuscular electrical stimulation on swallowing function in post stroke dysphagia Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-12 Nevine El Nahas, Hossam Shokri, Ahmed Refaat, Hanaa Mousa, Aya Hamid, Amr Abdel Monem, Eman AbuShady
Transcranial direct current stimulation (tDCS) and neuromuscular electrical stimulation (NMES) are noninvasive neuromodulation techniques that have shown positive effects in a variety of neurological disorders. Most protocols apply one modality at a time. Here we tested the effect of tDCS applied together with NMES on patients with dysphagia after acute stroke. To assess the efficacy of combined tDCS
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A case report of X-linked CDKL5 gene variant in monozygotic twins associated with developmental and epileptic encephalopathy-2 Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-12 Aayushi Gupta, Prashant Utage, Aparna Prashant Utage, Nadir Aman, Akhilesh Pujar
CDKL5 (Cyclin‐Dependent Kinase Like-5) deficiency disorder (CDD; Online Mendelian Inheritance in Man database 300203, 300672) is a rare neurologic disorder, which is caused by mutation in CDKL5 gene, situated on the X chromosome. Therefore, this condition is inherited in an X-linked dominant pattern. In general, this gene provides instruction for making a protein that is essential for normal brain
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Assessing emotional intelligence domains and levels in substance use disorders Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-09 Hanan Faried Maghawry, Alaa M. Darwish, Naglaa Abd ElMegeed Mohammed, Nadia Abd El-ghany Abd El-hameed, Gellan K. Ahmed
Many individuals with substance use disorders face challenges in their social interactions and often have strained relationships with peers. Challenges related to problem-solving, stress management, and impulsivity often contribute to their substance use disorders. Emotional intelligence plays a pivotal role in assisting individuals with substance use disorders in coping with stress, enhancing peer
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Relation between metabolic syndrome and psychiatric symptoms severity in women with premenstrual syndrome Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-08 Mohamed Basiouny Yahia, Medhat Ali Salah, Seham Sabry, Mahmoud Osama Ahmed Abd El Fattah, Nashwa El-Khouly, Samir Khamis Galal, Mohamed Elsayed Hammour, Wael Abd Elatief Khafagy, Mohamed Alkhouly, Mustafa A. A. Osman, Eman Gomaa Rezk, Hend Mohamed Hussein, Sarah Hossam Eldin Mostafa, Abdelaziz Mahmoud Abdelaziz, Sara Sallam
Premenstrual syndrome (PMS) is a clinical condition characterized by recurrent moderate-to-severe affective, physical, and behavioral symptoms during the menstrual cycle. The present study aimed to assess the relation between metabolic syndrome (MetS) and symptoms severity in patients with premenstrual syndrome (PMS). This multicentric propensity score matched analysis included 300 women with PMS.
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Factors predicting functional outcome after rtPA for patients with acute ischemic stroke Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-07 Yasser Hamed, Mahrous I. Seddeek, Ali Mahmoud Ahmed, Talal A. Dawa, Hasan Hashem, Adel M. Othman, Abdel-Ghaffar I. Fayed, Noran Elbazzar, Ramy A. Metwally, Mostafa El Sayed Abd Elghany El Sayed, Ahmed Yousry, Abd Elaziz Shokry
Accurate outcome prediction for patients with acute ischemic stroke after intravenous recombinant tissue plasminogen activator (rtPA) treatment is essential for optimizing patients’ management. We aimed to identify factors associated with unfavorable outcomes following intravenous rtPA treatment. This study was carried out on 162 patients who presented with acute ischemic stroke within 4.5 h from onset
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Transcranial ultrasonography as a predictor of disease progression in multiple sclerosis Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-02 Ebtesam Fahmy, Hanan Helmy, Nahla Aly Merghany, Rania Shehata Ismail, Nesma Mounir
Development of novel biomarkers for multiple sclerosis (MS) is of utmost importance to improve the capability to predict disease progression and disability. Transcranial ultrasonography (TCS) is a noninvasive imaging technique that allows the visualization of major parenchymal structures. This study aimed to evaluate the role of parenchymal transcranial sonography as a predictor for disease severity
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Depression and anxiety and its association with problematic social media use in the MENA region: a systematic review Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-02-01 Samira Abbouyi, Samira Bouazza, Soukaina El Kinany, Karima El Rhazi, Btissame Zarrouq
The use of the social media has increased significantly in recent decades, and research on the impact of problematic social media use on mental health is a relatively new and growing area of study in the Middle East and North Africa (MENA) region. Social media users are prone to developing addictive behaviors and suffering from mental illness, including depression and anxiety. The present paper aims
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ChatGPT in psychiatry: promises and pitfalls Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-30 Rebecca Shin-Yee Wong
ChatGPT has become a hot topic of discussion since its release in November 2022. The number of publications on the potential applications of ChatGPT in various fields is on the rise. However, viewpoints on the use of ChatGPT in psychiatry are lacking. This article aims to address this gap by examining the promises and pitfalls of using ChatGPT in psychiatric practice. While ChatGPT offers several opportunities
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Risk factors, clinical presentation and 1-year outcome of ischemic stroke caused by small artery disease Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-30 Tarek Mohammed Elgammal, Hazem Abd El Rahman Fayed, Ahmed Mohamad Basiouny El Shamy, Mohammed Adel Eltomy, Moustafa Mahgoub Awwad
The prevalence of ischemic stroke (IS) caused by small-artery disease (SAD) is increasing recently. The present study aimed to report the risk factors, clinical presentations and outcome in patients presented with IS due to SAD with follow up for one year. The present study included 100 patients with IS due to SAD diagnosed on the basis of clinical and radiological findings. All patients were submitted
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Public knowledge of risk factors and warning signs of heart attack and stroke Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-29 Pedro Pallangyo, Zabella S. Mkojera, Makrina Komba, Loveness Mfanga, Saad Kamtoi, Janeth Mmari, Husna Y. Faraji, Smita V. Bhalia, Henry A. Mayala, Genofeva Matemu, Anna Nkinda, Engerasiya Kifai, Peter R. Kisenge
Knowledge of the predisposing risk factors and prompt recognition of the warning signs for heart attack and stroke is fundamental in modification of lifestyle behaviors and an imperative precursor to health-seeking behavior. In view of an existing knowledge gap amidst increasing incidence of heart attack and stroke in Tanzania, we conducted this community-based cross-sectional study among residents
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Percutaneous full-endoscopic transforaminal discectomy versus open microdiscectomy in the treatment of lumbar disc herniation: randomized controlled trial Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-24 Moustafa Mohamed Kandeel, Magdy Gamal Abdel Kader Yousef, Abdelfattah Mohamed Fathy Saoud, Zakaria Hassan Ibrahim Abu-Elghait
Lumbar disc herniation is one of the most common degenerative spine conditions. In our center, the standard surgical technique for treatment of lumbar disc herniation is open microdiscectomy. The full-endoscopic transforaminal discectomy is done for selective cases of lumbar disc herniation under local anesthesia, achieving good results. This study aims to compare the clinical outcomes, operative data
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Highlights on the link between vitamin D and lipid panel in Egyptian multiple sclerosis patients Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-22 Mahmoud S. Swelam, Azza Abdel Nasser, Janet Masoud, Rasha Mamdouh, Shima Said, Mohamed Abdel Hafeez
Diversity of risk factors, namely, vitamin D and lipid panel abnormalities, are connected to multiple sclerosis (MS) etiology and may possess an influential role on disease course. In a cross-sectional study, we correlated the demographic, clinical and radiological characteristics of 111 relapsing–remitting MS (RRMS) patients with their serum levels of vitamin D and lipid profile to evaluate the consequences
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Application of unilateral biportal endoscopy technique to resect a thoracic spinal intradural extramedullary meningioma: technical report and review of the literature Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-15 Rongxue Shao, Wei Cheng, Wei Zhang, Jiaming Liang, Liqi Ruan, Chengyue Zhu, Hao Pan
Meningiomas are common intradural extramedullary spinal tumors, which arise from arachnoid cap cells in the leptomeninges surrounding the brain or spinal cord. Sensory and motor dysfunction as well as pain were the most common presenting symptoms. Surgical resection remains the primary treatment for spinal intradural extramedullary meningiomas. Traditionally, spinal meningiomas excision requires longer
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Cerebral venous sinus thrombosis manifesting as chronic spontaneous subdural hematoma: case report and review of the literature Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-11 Fares Laouar, Yasser Brahmia, Lotfi Boublata
Cerebral venous sinus thrombosis (CVST) is a rare form of stroke that is mainly seen in young women. It is frequently associated with hemorrhagic venous infarction and subarachnoid hemorrhage. There are few reports of CVST associated with chronic non-traumatic subdural hematoma (SDH). The diagnosis of CVST with spontaneous SDH is difficult because of the variability of its clinical features. The management
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Targeting the molecular web of Alzheimer’s disease: unveiling pathways for effective pharmacotherapy Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-11 Devika Jadhav, Nikita Saraswat, Neeraj Vyawahare, Devendra Shirode
Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinically, it is distinguished by a transition from episodic memory to a gradual reduction in cognitive ability leading to cognitive dysfunction. Neurofibrillary tangles and amyloid plaques are unique structures that are thought
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Semmes Weinstein monofilament test for detection of diabetic peripheral neuropathy: sensitivity and specificity Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-10 Vishnumoorthy Aithal, Smitha Bhat
Peripheral neuropathy predisposes to diabetic foot and this predilection is worsened by poorly controlled sugars. Diabetic foot increases the mortality and morbidity associated with diabetes. Thus, it is crucial to screen for diabetic polyneuropathy. Early detection of diabetic polyneuropathy improves foot care and decreases morbidity. This study aimed to assess the sensitivity of Semmes Weinstein
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Drug resistance predictive utility of age of onset and cortical imaging abnormalities in epilepsy: a systematic review and meta-analysis Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-10 Kehinde Alare, Bridget Ogungbemi, Ayomide Fagbenro, Busayo Adetunji, Oladoja Owonikoko, Taiwo Omoniyo, Habiblah Jagunmolu, Ayomide Kayode, Samson Afolabi
Drug resistance has been a global burden in the management of epilepsy. It is desirable if this could be predicted earlier in the course of management to give time for alternative and a more definitive mode of management, such as epilepsy surgeries. We conducted a systematic review and meta-analysis to investigate the relationship between elevated age at the onset of the first seizure or cortical imaging
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Early detection of peripheral neuropathy in patients with diabetes mellitus type 2 Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-10 Ahmed W. Fadel, Amin E. Nawar, Loai M. Elahwal, Azza A. Ghali, Osama A. Ragab
Early diagnosis of diabetic polyneuropathy (DPN) can significantly improve the prognosis and help prevent severe complications. The aim of this work was to study clinical, radiological, laboratory and neurophysiological findings for early detection of peripheral neuropathy in T2DM. A total of 60 diabetic patients were classified according to Toronto Clinical Neuropathy Score (TCNS) into: Group 1: 20
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Effect of anti-epileptic drugs usage on thyroid profile in Egyptian epileptic children Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-08 Amira Rafik, Nahed Salah El-Din, Naglaa Mohamed El Khayat, Maha Nada, Eman Mones Abushady
The long-term use of anti-seizure medications (ASMs) adversely affects thyroid, lipid profile and other metabolic functions. Subclinical hypothyroidism and alterations in thyroid hormone serum levels are reported with older ASMs in adults with limited and conflicting data of the influence of ASMs especially newer one on thyroid function in children. This study aimed to investigate the effects of conventional
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Early versus late diagnosis of LAMA2 congenital muscular dystrophy: a distinct consequence Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-05 Chien-Heng Lin, Sheng-Shing Lin, Syuan-Yu Hong, Chieh-Ho Chen, I-Ching Chou
Laminin subunit alpha 2 (LAMA2)-related muscular dystrophy (LAMA2 MD) is caused by homozygous or compound heterozygous mutations in LAMA2 (OMIM#156225), located on chromosome 6q22. We describe two patients with LAMA2 MD treated at a Taiwanese hospital. Both presented with gradual hypotonia starting in early infancy. A targeted muscular dystrophy/myopathy panel and whole-exome sequencing were used as
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Predictors of progression of multiple sclerosis in a sample of Egyptian patients Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2024-01-03 Manar A. Shawky, Tarek I. Menecie, Eman M. Saif El Deen, Mohammed H. Rashad
Multiple sclerosis (MS) is a multifactorial neurodegenerative autoimmune disease with a varied clinical course and presentation, which is more frequent than ever in the Middle East. The aim of this work is to investigate potential predictors of MS progression in order to help in early diagnose and predict progressive course of the disease. This is a retrospective case–control study conducted on a group
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Exploring the effect of transcranial magnetic stimulation on quality of sleep in Parkinson’s disease Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-20 Hala A. Shaheen, Mohammed Gomaa, Mohammed M. Maarouf, Lamiaa I. Daker
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive therapeutic approach that targets particular brain regions that had been used and displayed significant impact in various neurological disorders. This study aimed to explore if high-frequency (HF) rTMS over the parietal cortex could influence sleep quality in Parkinson's disease (PD). This was a prospective sham-controlled study conducted
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COVID-19 and optic neuritis: a series of three cases and a critical review Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-20 Uddalak Chakraborty, Jasodhara Chaudhuri, Amlan Kusum Datta, Adreesh Mukherjee, Alak Pandit, Biman Kanti Ray, Goutam Gangopadhyay
The novel coronavirus disease (COVID-19) has claimed innumerable lives globally since its onset and several extrapulmonary manifestations of the disease have been reported in association with COVID-19. Although optic neuropathy has been previously linked to a variety of infections, neuro-ophthalmological associations of SARS-CoV-2 have been sparsely reported till date. Our aim was to report the clinical
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Digital subtraction angiography findings of stroke in young adult population: a multi-center record-based study Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-18 Kumara Tini, Eric Hartono Tedyanto, Deddy Andaka, Nyoman Angga Krishna Pramana, I Putu Eka Widyadharma
Stroke is one of the main causes of disability, in which nearly 2/3 of survivors experience disability and interferes with the patient’s daily functional activities. Hypertension, dyslipidemia, obesity, and smoking habits are the main causes of stroke in young adults. Vascular abnormalities are also risk factor for stroke in young adults. Advanced imaging examinations such as cerebral digital subtraction
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Efficacy of single burr hole with irrigation and sub-dural drain in the evacuation of chronic subdural hematoma Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-13 Mahmoud Ahmed Gomaa, Ashraf Abdellatif Osman, Ahmed Hosameldin Aboelhuda
Chronic subdural hematoma (CSDH) remains one of the most common types of traumatic and spontaneous intracranial hematomas. The optimal method of treatment has not been definitely established. Surgical treatment options includes craniotomy, trephination, burrhole drainage and twist drill perforation. This study aimed at the evaluation of the clinical and radiological outcome after the efficacy of single
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Bortezomib in the management of anti-NMDA receptor encephalitis Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-11 Bryan Gervais de Liyis, Jane Carissa Sutedja, Maria Pramesthi Sabrina Evananda, Ledwin Meikel Wibisono, Chrysanta Paramitha Karuniamaya, Cindy Thiovany Soetomo, Ni Made Susilawathi
Anti-N-methyl d-aspartate (NMDA) receptor encephalitis is an autoimmune encephalitis characterized by neuronal surface antibodies targeting NMDA receptor in the spinal fluid and serum. After acute disseminated encephalomyelitis, anti-NMDA receptor encephalitis is the most frequent cause of autoimmune encephalitis. Despite its clinical significance, the exact prevalence and optimal treatment strategies
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Seroprevalence of Campylobacter jejuni infection in common subtypes of Guillain–Barre syndrome in Kashmiri population Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-11 Feroze Mir, Waseem Dar, Arjimand Yaqoob, Maqbool Wani, Ravouf Asmi, Mushtaq Wani
Guillain–Barre Syndrome (GBS) is a common differential diagnosis of acute-onset flaccid quadriparesis with or without bulbar involvement. Various illnesses precede GBS, respiratory illness being the most common. Campylobacter jejuni is the single most common organism found associated with GBS. The aim of the present study was to determine the prevalence of Campylobacter jejuni positivity in different
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Unmasking the mitochondrial mystery: febrile illness exposing a rare cause of refractory epilepsy with unique imaging features: a case report Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-11 Nikhita Suzanne Roshan, K. Vimala Christina Colaco, Fathima Raeesa, Safwan Ahmed
Mitochondrial DNA polymerase, which is encoded by the POLG (polymerase gamma) gene, is responsible for the replication of the mitochondrial genome. Around 300 pathogenic variants have been identified in this gene and the clinical impact of POLG mutations is highly variable in both severity and phenotype. Our case had a clinical presentation distinct from the known mitochondrial syndromes associated
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Generalized dystonia following resuscitation from a cardiac arrest: a case report and review of the literature Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-08 Ahmadou Bamba Mbodji, Maouly Fall, Ndiaga Matar Gaye, Mamadou Ka, Jean Claude Dione, Moustapha Ndiaye, Amadou Gallo Diop
A wide variety of movement disorders can be observed after cerebral hypoxia, including akineto-hypertonic syndrome and dystonia. Post-anoxic dystonia is a rare clinical syndrome that is not widely reported in the literatures. It is thought to be related to cerebral hypoxia leading to ischaemia of the basal ganglia. We report a case of an 11-year-old girl who represented with generalized dystonia following
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Sensitivity of non-conventional electro-diagnostic techniques to detect neuropathy in patients with hepatitis “C” viral infection Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-06 Reem M. Gabr, Saly H. Elkholy, Mye A. Basheer, Marwa Khairy, Dina A. El Salmawy
Hepatitis “C” virus (HCV) infection has become a growing global health concern. Chronic HCV infection is usually accompanied by extra-hepatic manifestations. Peripheral neuropathies are the most common neurological complications. Electrophysiological tests play an important role in diagnosing polyneuropathy and identifying its pathophysiology. This study aimed at highlighting the sensitivity of non-conventional
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Meeting the neurology demand: the impact of early exposure and mentorship on African medical students Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-12-04 Nicholas Aderinto
To the Editor Neurological disorders represent Africa’s growing public health challenge [1]. According to the World Health Organization (WHO), these conditions account for a significant portion of the disease burden on the continent [2]. However, the number of neurologists in Africa is disproportionately low compared to the population's needs [3]. The presence of trained neurologists in Africa is far
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Micro-RNA in a sample of Egyptian patients with incidental cerebral small vessel disease Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-11-30 Mohamed Maged, Nevine El Nahas, Mai Fathy, Ayman Kilany, Eman Hamid, Hany Aref
Despite being the cause of morbidity and mortality in many patients, little is known about the pathophysiology of cerebral small vessel disease (CSVD). Identifying new biomarkers is mandatory for early diagnosis and proper management. The aim of this study is to investigate the role of micro-RNA as a biomarker for incidental cerebral small vessel disease (iCSVD) and its clinic-radiological correlates
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Self-diagnose is associated with knowledge and attitude towards mental illness of university students in Indonesia Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-11-28 Naufal Arif Ismail, Intan Kusumaningtyas, Moetrarsi Sri Kanapsijah Firngadi
Mental illness is still stigmatized and poorly understood in Indonesian society, but university students could be a key target for promoting positive attitudes and increasing awareness. This study aims to explore the knowledge and attitudes of university students in Indonesia toward mental illness and to identify associated factors, emphasizing self-diagnosis. An analytical cross-sectional study on
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Anti-Hu antibody seropositive neuropathy with large and small fiber involvement mimicking alcoholic neuropathy: a case report Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-11-28 Michail Papantoniou, Thomas Zampelis, Michail Rentzos, Dimitrios Karakalos
Anti-Hu antibody neuropathy is considered a rare acquired peripheral neuropathy, but common among paraneoplastic syndromes. Typically, is described as subacute sensory neuronopathy and electrophysiological findings are usually suggestive of a sensory axonal neuropathy. We report the case of a 67-year-old man referred to our clinic with a 4-month history of progressive pain and paresthesias of distal
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The day after intracerebral hemorrhage: platelet mass index as predictor of survival—a retrospective cohort study Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-11-27 Despoina Avramidou, Rengina Goulimari, Anastasios Stergiou, Vasileios Papadopoulos
Platelets are implicated in the pathophysiology of intracerebral hemorrhage (ICH). Platelet count (PLT) is affected by platelet loss, while mean platelet volume (MPV) by platelet replenishment. Whether platelet mass index (PMI), the product of PLT and MPV, might predict survival after ICH, remains unknown. All first-ever ICH patients, admitted to Xanthi General Hospital between January 2018 and May
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Acceleration of sporadic Creutzfeldt–Jakob disease progression by COVID requires evidence from appropriately designed studies Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-11-27 Josef Finsterer
The aim of this letter to the editor is to discuss the influence of SARS-CoV-2 infection on the progression of sporadic Creutzfeldt–Jakob disease (sCJD). A 73-year-old male was diagnosed with sCJD based on the clinical presentation, cerebral MRI, FDG–PET, and elevated 14-3-3 in cerebrospinal fluid. One month earlier he had suffered a slight COVID-19 infection. It was concluded that COVID-19 can lead
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Predictive value of the anterior communicating artery (ACoA) complex variations for the incidence and rupture of ACoA aneurysms Egypt. J. Neurol. Psychiatry Neurosurg. Pub Date : 2023-11-20 Bahaa Ghareeb Hassanin, Ahmed Kamal Abdelhameid, Mohamed Abdala Abbas, Reham Bakry Mohamed, Karl-Michael Schebesch
Increase pressure on arteries branching points and curves (hyperdynamic theory) is the most popular theory to explain the aneurysms formation that augmented by the observation of high incidence of anomalies (either A1 aplasia or hypoplasia) and the anterior communicating artery (ACoA) aneurysms. It still underestimated the correlation between these anatomical anomalies and aneurysm occurrence and its