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Metastatic Hepatocellular Carcinoma Represents an Important but Rare Pitfall in the Diagnostic Evaluation of ER Negative Ovarian Malignancy: A Case Report. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-10-04 Mthulisi Viki,Rebecca Morrow
Metastatic hepatocellular carcinoma (HCC) to the ovary is a rare and challenging histopathological diagnosis in the absence of the relevant clinical history. The differential diagnoses of a hepatoid tumor in the ovary are extensive, and correct diagnosis requires well-considered clinical-pathologic correlation. Familiarity with the diverse architectural patterns and immunophenotype of HCC is essential;
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Prospective Clinical Prognostication of Endometrial Carcinomas Based on Next-Generation Sequencing and Immunohistochemistry-Real-World Implementation and Results at a Tertiary Care Center. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-10-04 Kurtis D Davies,Lynelle P Smith,Amy Guimaraes-Young,Bradley R Corr,Christine M Fisher,Saketh R Guntupalli,Amber A Berning,Miriam D Post,Devon Pino,Dara L Aisner,Rebecca J Wolsky
Based on findings from The Cancer Genome Atlas and the Proactive Molecular Risk Classifier for Endometrial Cancer algorithm, endometrial carcinoma can now be stratified into 4 prognostically distinct subgroups based on molecular alterations and immunohistochemical (IHC) aberrations. In this study, we describe the de novo adoption and clinical reporting of prognostic subgroup classification based on
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Fibroepithelial Stromal Polyp of the Vulvovaginal Region as Part of the RB1 Family of Tumors: Friend or Foe? Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-10-04 Fleur Cordier,Nadine Van Roy,Bart Matthys,Pascale De Paepe,Koen Van de Vijver,Jo Van Dorpe,David Creytens
Fibroepithelial stromal polyps (FSPs) are benign mesenchymal lesions occurring in the vulvovaginal region. Following the identification of loss of Retinoblastoma 1 (RB1) on immunohistochemical staining in routine practice, we stained a series of FSPs and performed additional fluorescence in situ hybridization (FISH) and copy number variation (CNV) sequencing to detect losses/deletions in the Retinoblastoma
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Synchronous Bilateral Ovarian Mesonephric-like Adenocarcinomas with Separate Origins from High-Grade Mullerian Adenosarcoma and Endometriosis: Report of a Rare Case. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-10-04 Zitong Zhao,Ravichandran Nadarajah,Inny Busmanis
Mesonephric-like adenocarcinoma (MLA) of the ovary is a recently recognized, rare malignancy with aggressive clinical behavior, and is thought to originate from Mullerian epithelium with mesonephric transdifferentiation. Emerging evidence suggests that MLA may be classified as an endometriosis-associated neoplasm. The presence of a sarcomatous component within MLA is extremely rare, with common differential
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The Relationship Between Melatonin 1-2 Receptor Expression in Patients With Epithelial Ovarian Cancer and Survival. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-10-04 Elifnur Bicer,Tugan Bese,Deniz Dilan Tuzun,Sennur Ilvan,Basak Ozge Kayan,Fuat Demirkiran
Melatonin has antiproliferative, antiangiogenic, apoptotic, and immunomodulatory properties in ovarian cancer. Considering those, we evaluated the relationship between melatonin 1 (MT1) and melatonin 2 receptor (MT2) expression in tumor tissues of patients with epithelial ovarian cancer, disease-free survival (DFS), and overall survival (OS). Patients who received primary surgical treatment for epithelial
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Endometrioid Adenocarcinoma With "Burrowing" Invasion of the Cervix Represents a Separate Primary From the Concurrent Uterine Corpus Endometrial Endometrioid Adenocarcinoma: Histology, Immunohistochemistry, and Next-generation Sequencing Study of a Single Case. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-22 Yan Li,Jackson Chen,Shuang Niu
A small subset of endometrial endometrioid adenocarcinoma cases first reported in 2003, showed a distinct cervical component with a so-called "burrowing" invasion pattern. Initially, the cervical component was regarded as cervical involvement by the endometrial adenocarcinoma. However, a 2010 study argued that these cases actually might represent separate primary endometrial and cervical endometrioid
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Ovarian Endometrioid Adenocarcinomas With Infiltrative "Adenofibroma-like" Morphology and Aberrant ß-catenin Expression: Tumors That Coexpress CDX2 and LEF1 With Frequent Neuroendocrine Marker Expression, Diminished/Lost PAX8 and Possible Association With Endometrioid Type II Stem Cell Outgrowths in the Fallopian Tube. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-22 Jin Xu,Stephanie M McGregor,Kay J Park,Paul S Weisman
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Uterine Neurotrophic Tyrosine Receptor Kinase Rearranged Spindle Cell Neoplasms: Three Cases of an Emerging Entity. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-22 Lucy Grant,William Boyle,Sarah Williams,Jennifer Pascoe,Raji Ganesan
Uterine sarcomas are rare; most are either smooth muscle or endometrial stromal in origin. Recent molecular advances have identified several, genetically defined entities with specific morphologic, clinicopathological associations, and therapeutic options. We report 3 cases of uterine neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasms," currently classified as "emerging
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Divergent Malignant Melanocytic Differentiation in Ovarian Endometrioid Adenocarcinoma With Aberrant β-Catenin Expression: A Case Expanding the Histologic Spectrum of β-Catenin Activated Gynecologic Neoplasia. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-22 Jin Xu,Paul S Weisman
Divergent differentiation in gynecologic carcinomas encompasses a broad range of lineages, including mesenchymal, germ cell, high-grade neuroendocrine, neuroectodermal, and cutaneous adnexal differentiation. Here we present a case of ovarian endometrioid adenocarcinoma with divergent malignant melanocytic differentiation (MMeD). The background ovarian endometrioid adenocarcinoma showed focally aberrant
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Dedifferentiated Leiomyosarcoma-morphology, Immunohistochemistry, and Molecular Findings of a Case and Review of Literature. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-08 Aisha Kousar,Abigail I Wald,Michelle Heayn,Nicholas D Cardillo,Esther Elishaev,Rohit Bhargava
We present a case of uterine dedifferentiated leiomyosarcoma in a 42-yr-old woman who presented with severe abdominal pain and vaginal bleeding. The mass measured 10.5 cm. The "differentiated" tumor component ranged from leiomyoma-like areas to smooth muscle tumor of uncertain malignant potential to frank leiomyosarcoma. The undifferentiated tumor component showed extreme hypercellularity, intermediate
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Diagnostic Challenges and Long-term Outcomes of Neuroendocrine Carcinoma of the Cervix: A Case Series. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-08 Kelly Lamiman,Alyeesha B Wilhelm,Eduardo Eyzaguirre,Gwyn Richardson
Neuroendocrine carcinomas (NECs) of the cervix are rare, aggressive malignancies that are challenging to diagnose and treat. They are high-grade lesions that often share features with poorly differentiated adenocarcinoma and squamous cell carcinoma. NECs are classified into large-cell or small-cell subtypes but can often have a mixed appearance or occur concurrently with a squamous or adenocarcinoma
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Synchronous Endometrial and Ovarian Carcinomas: Pathologic and Molecular Analysis Highlights the Monoclonal Origin of the Lesions. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-08 Angela Guerriero,Margherita Moro,Valentina Angerilli,Giada Munari,Luisa Santoro,Lara Alessandrini,Lara Favero,Giulia Tasca,Matteo Fassan,Angelo Paolo Dei Tos
The diagnosis of synchronous carcinomas, involving both the endometrium and ovaries, is not a rare finding in gynecologic pathology and represents a challenge with implications on tumor staging and therapeutic decision-making. A mono-institutional series of 11 metastatic and 6 paired synchronous endometrial and ovarian carcinomas were reviewed by 2 expert pathologists based on previously published
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Mullerian Polyp of the Vagina: Report of Three Cases of a Previously Undescribed Lesion With Discussion of the Differential Diagnosis. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-08 Rupali Arora,W Glenn McCluggage
Benign and malignant neoplasms of the vagina are rare. We report 3 primary vaginal polypoid lesions involving the upper or mid-vagina in patients aged 40, 60, and 67 years. The lesions bore a striking morphologic resemblance to benign endocervical or endometrial polyps and we suggest the designation Mullerian polyp of the vagina. As far as we are aware, similar cases have not been reported previously
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Molecular Classification of Endometrial Endometrioid Carcinoma With Microcystic Elongated and Fragmented Pattern. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-08 Baohui Ju,Jianghua Wu,Lin Sun,Chunrui Yang,Hu Yu,Quan Hao,Jianmei Wang,Huiying Zhang
The studies on the molecular classification of endometrioid carcinoma (EC) with microcystic, elongated, and fragmented (MELF) pattern invasion are limited. In this study, 77 cases of ECs with MELF patterns in Chinese women were collected. The molecular classification of the fifth edition of the World Health Organization was used to classify the molecular subtypes using immunohistochemistry staining
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Estrogen/Progesterone Receptor Expression and Cancer Antigen 125 Level as Preoperative Predictors to Estimate Lymph Node Metastasis in Endometrioid Endometrial Cancer. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-09-08 Shao-Chi Wang,Chen-Hsuan Wu,Hung-Chun Fu,Yu-Che Ou,Ching-Chou Tsai,Ying-Yi Chen,Ying-Wen Wang,Szu-Wei Hunag,Szu-Yu Huang,Jui Lan,Hao Lin
Loss of estrogen receptor/progesterone receptor (ER/PR) in endometrial cancer (EC) is associated with tumor progression and poor outcomes. Elevated pretreatment cancer antigen 125 (CA 125) level is a risk factor for lymph node metastasis (LNM). We evaluated whether the combination of ER/PR expression and CA 125 level could be used as a biomarker to predict LNM. We retrospectively investigated patients
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SATB2 Cytoplasmic Expression is Characteristic of a Subset of Ovarian Stromal Cells and Sex Cord Stromal Tumors. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-25 Maysa Al-Hussaini,W Glenn McCluggage
Special AT-rich sequence-binding protein 2 (SATB2) is a nuclear transcription factor that shows consistent nuclear staining in colorectal adenocarcinoma and osteosarcoma. Following the observation of cytoplasmic staining with this marker in luteinized ovarian stromal cells, we studied the expression of SATB2 in ovarian stromal cells, various types of follicular cysts, and sex cord-stromal tumors. Eighty-five
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Prevalence and Prognostic Significance of PIK3CA Mutation and CNV Status and Phosphorylated AKT Expression in Patients With Cervical Cancer Treated With Primary Surgery. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-25 Kevin Martell,John B McIntyre,Tasnima Abedin,Elizabeth N Kornaga,Angela M Y Chan,Emeka Enwere,Martin Köbel,Michelle L Dean,Tien Phan,Prafull Ghatage,Susan P Lees-Miller,Corinne M Doll
Currently, there are limited and conflicting reports on the prognostic utility of PIK3CA and associated pathway markers for cervical cancers treated with primary surgical management. Moreover, current studies are lacking complete characterization of adjuvant treatment with RT and/or chemotherapy. We aimed to document the prevalence, clinicopathologic, adjuvant treatment details, and prognostic value
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Perceptions of Controversies and Unresolved Issues in the 2014 FIGO Staging System for Endometrial Cancer: Survey Results From Members of the International Society of Gynecological Pathologists and International Gynecologic Cancer Society. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-18 Neslihan Kayraklioglu,Levon Katsakhyan,Paul A Cohen,Naveena Singh,Joseph T Rabban,Xavier Matias-Guiu
Long-standing controversial and unresolved issues in the current "International Federation of Gynecology and Obstetrics" staging system for endometrial cancer are well-recognized by pathologists and clinicians alike and exist primarily as a result of limitations to the existing literature. To guide the design of future outcome-based studies specifically aimed at resolving such gaps, the International
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Uterine Sarcoma With EML4::NTRK3 Fusion: A Spectrum of Mesenchymal Neoplasms Harboring Actionable Gene Fusions. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-14 João Víctor Alves de Castro,Pedro José Silva Dos Santos,Henrique Mantoan,Glauco Baiocchi,Graziele Bovolim,Giovana Torrezan,Marcelo Corassa,Antônio Geraldo do Nascimento,Marina De Brot,Felipe D'Almeida Costa,Louise De Brot
NTRK gene fusions are part of a paradigm shift in oncology, arising as one of the main genomic alterations with actionability in the so-called "agnostic setting." In gynecologic pathology, the recent description of uterine sarcoma resembling fibrosarcoma and with NTRK rearrangements (NTRK-rearranged uterine sarcoma) highlights the importance of recognizing clinicopathological cues that can lead to
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Extraovarian Dysgerminoma Involving the Uterine Cervix: A Rare Case Report With Literature Review. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-14 Yasunori Yoshino,Shiori Yanai,Mari Sawada,Shintaro Sakate,Kiyoshi Kanno,Tomonori Hada,Toshihiro Ueda,Tetsuya Tabata,Masako Omori,Masaaki Andou
Primary extraovarian dysgerminoma (EOD) is a very rare disease. There is no literature about primary EOD involving the uterine cervix. We herein present details of a unique case of primary EOD involving the uterine cervix. A 46-year-old woman with uterine cervical tumor was referred to our institution with atypical genital bleeding. A polypoid tumor localized to the uterine cervix was found. Cervical
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Hematoxylin and Eosin Staining Helps Reduce Maternal Contamination in Short Tandem Repeat Genotyping for Hydatidiform Mole Diagnosis. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-11 Yating Zhao,Luya Cai,Xiaofei Zhang,Huifang Zhang,Limeng Cai,Lin Zhou,Bo Huang,Jianhua Qian
Short tandem repeat (STR) genotyping provides parental origin information about aneuploidy pregnancy loss and has become the current gold standard for hydatidiform moles diagnosis. STR genotyping diagnostic support most commonly relies on formalin-fixed paraffin-embedded samples, but maternal contamination is one of the most common issues based on traditional unstained sections. To evaluate the influence
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Comprehensive Immunohistochemical Analysis of Mesonephric Marker Expression in Low-grade Endometrial Endometrioid Carcinoma. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-11 Yurimi Lee,Sangjoon Choi,Hyun-Soo Kim
Immunohistochemical markers shown to be useful in identifying/confirming mesonephric/mesonephric-like differentiation (MLD markers) include thyroid transcription factor (TTF1), GATA-binding protein 3 (GATA3), and cluster of differentiation 10 (CD10). Only a few studies have examined the expression levels of MLD markers in endometrial endometrioid carcinomas (EECs). This study aimed to analyze the frequency
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ZC3H7B-BCOR Fusion High-grade Endometrial Stromal Sarcoma With Morphologic Features of Low-grade Endometrial Stromal Sarcoma. A Case Report and Review of Literature. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-10 Longmei Zhao,Yu-Wei Cheng,Maria Luisa C Policarpio-Nicolas
High-grade endometrial stromal sarcomas with ZC3H7B-BCOR fusion are rare. They are predominantly located in the endomyometrium, with morphologic features characterized as haphazardly arranged fascicles of spindle cells with mild to moderate atypia, abundant myxoid matrix, high mitotic index, and tongue-like/pushing patterns of myometrial invasion. Furthermore, conventional or variant low-grade endometrial
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Endometrioid Squamous Proliferations of the Endometrium Express Alpha-Methylacyl-CoA Racemase (P504s). Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-10 Maryam Tahir,Shabnam Samankan,Marilyn Huang,Andre Pinto
Squamous morular metaplasia is closely associated with endometrioid proliferative lesions, such as endometrial intraepithelial neoplasia, whereas endometrioid adenocarcinomas (endometrioid carcinoma) may also demonstrate squamous differentiation (morular or nonmorular). Alpha-methylacyl-CoA racemase (AMACR; P504s) is an immunohistochemistry marker expressed in many tumors, including prostate adenocarcinoma
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p16 Block Type Overexpression, p53 Wild Type Reactivity, and Cervical Involvement do not Always Exclude the Diagnosis of Primary Endometrial Squamous Cell Carcinoma (PESCC). Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-08-10 Daniela Fanni,Clara Gerosa,Michele Peiretti,Valerio Mais,Elena Massa,Stefano Angioni,Gavino Faa
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Defining the Nature and Clinicopathologic Significance of Mallory-Denk-like Inclusions in Ovarian Fibromas: A Potential Degenerative Phenomenon Associated With Torsion. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-07-18 Kritika Krishnamurthy,Isaac E Stillman,Jonathan L Hecht,Monika Vyas
Mallory-Denk bodies (MBD), described in alcoholic hepatitis, are composed of intermediate filaments admixed with other proteins. These cytoplasmic inclusions are irregularly shaped and eosinophilic as seen under the light microscope. MBD-like inclusions have rarely been described outside the hepatobiliary tree. Though rare, intracytoplasmic inclusions have been reported in ovarian fibromas. This study
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Moderately-differentiated Ovarian Sertoli-Leydig Cell Tumor With a Concurrent Serous Borderline Tumor in a 16-year-old Girl. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-07-18 Swati Bhardwaj,Natalie Banet,Emily C Gaston
Sertoli-Leydig cell tumors (SLCT) are rare tumors of the ovary with a peak incidence in the second to third decade of life. Serous borderline tumors (SBT) are epithelial ovarian neoplasms which occur at a median age of 50 years. A co-occurrence of SLCT and SBT has not yet been reported. Here, we describe a case of a 16-year-old girl who presented with irregular menses, virilization, and an abdominopelvic
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Programmed Death Ligand-1 (PD-L1) Expression in Cervical Squamous Cell Carcinoma: Does it Correlate With Outcomes? Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-07-18 Ashley L Monsrud,Vaidehi Avadhani,Marina B Mosunjac,Lisa Flowers,Uma Krishnamurti
Cervical cancer is one of the most common gynecological malignancies. Upregulation of programmed death ligand-1 (PD-L1), an immunoregulatory protein, is associated with an adverse outcomes in several malignancies. Most studies evaluating PD-L1 expression in cervical squamous cell carcinoma (CSCC) lack data on outcomes. In this study, we correlate PD-L1 expression with clinicopathologic factors and
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"Deciduoid" Change in Uterine Leiomyomas in Pregnancy: Aberrant Expression of Sex Cord Markers Inhibin and Calretinin. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-07-10 Jesús Machuca-Aguado,W Glenn McCluggage
Leiomyomas are common hormone-responsive uterine neoplasms which can exhibit a variety of morphologic changes secondary to hormonal agents such as progestogens. They may increase in size during pregnancy as a result of hormonal stimulation but surprisingly the morphologic features of leiomyomas in pregnancy are not well described in the literature. In this report, we describe the morphologic features
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HER2/ERBB2 Immunohistochemical Expression and Copy Number Status in Ovarian Mucinous Tumors. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-30 Marie C Smithgall,Anna Yemelyanova,Susan Mathew,Swarna Gogineni,Bing He,Taotao Zhang,Brian D Robinson,Jiangling J Tu
Primary mucinous ovarian carcinoma (MOC) is a rare ovarian epithelial cancer, which is often refractory to chemotherapy. HER2-targeting therapy is being increasingly considered in gynecologic malignancies. Although there have been limited studies examining the HER2 status of such tumors, the criteria for HER2 expression scoring have not been standardized for MOC as it has for other sites. This study
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TP53 as a Diagnostic Aid in the Distinction of Ovarian Mucinous Borderline Tumors From Mucinous Carcinoma. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-29 Eun Young Kang,Tatjana Terzic,Prafull Ghatage,Lawrence Woo,Kylie L Gorringe,Anthony N Karnezis,Cheng H Lee,Martin Köbel
Ovarian mucinous borderline tumors (MBTs) are clinically managed as benign neoplasms while the management of ovarian mucinous carcinomas (MC) is dependent on tumor stage. Despite the standardization of sampling of ovarian mucinous neoplasms, limited interobserver reproducibility between MBT and MC persists. Based on our recent finding that abnormal TP53 expression is associated with unfavorable outcome
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Uterine Leiomyosarcoma With Osteoclast-like Giant Cells: Report of 2 Cases and Review of Literature. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-15 Zhengshan Chen,Jianling Ji,Evan Yung,Sue Ellen Martin,Saloni Walia
Leiomyosarcoma (LMS) with osteoclast-like giant cells (OLGCs) is a rare entity with only 18 reported cases thus far. It is not known whether these OLGCs are a reactive or malignant component of LMS. Herein we describe the clinical, histologic, and molecular characteristics of 2 cases of LMS with OLGCs and perform a brief literature review. In 2 of our cases, the OLGCs, marked with CD68, had a low proliferation
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Herpes Pseudotumor Mimicking Cervical Cancer With Lymph Node Metastasis in an Immunocompetent Patient. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-15 Dane Wuori,Stephanie L Skala,David B Chapel
Anogenital herpes simplex virus (HSV) infection can rarely manifest as a pseudotumor, which some have termed "hypertrophic herpes." Almost all cases are in immunocompromised patients, typically with human immunodeficiency virus/acquired immune deficiency syndrome. This presentation often mimics malignancy clinically. We present a case of cervical HSV pseudotumor with associated lymphadenopathy in an
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Neuroendocrine Marker Expression in Primary Non-neuroendocrine Epithelial Tumors of the Ovary: A Study of 551 Cases. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-14 Michaela Kendall Bártů,Kristýna Němejcová,Romana Michálková,Quang Hiep Bui,Jana Drozenová,Pavel Fabian,Oluwole Fadare,Jitka Hausnerová,Jan Laco,Radoslav Matěj,Gábor Méhes,Adam Šafanda,Naveena Singh,Petr Škapa,Zuzana Špůrková,Simona Stolnicu,Marián Švajdler,Sigurd F Lax,W Glenn McCluggage,Pavel Dundr
Expression of neuroendocrine (NE) markers in primary ovarian non-NE epithelial tumors has rarely been evaluated. The aim of our study was to evaluate the expression of the most widely used NE markers in these neoplasms and to determine any prognostic significance of NE marker expression. The cohort consisted of 551 primary ovarian tumors, including serous borderline tumors, low-grade serous carcinomas
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A Case of Uterine Tumor Resembling Ovarian Sex Cord Tumor With Prominent Myxoid Features. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-14 Koki Ise,Zen-Ichi Tanei,Yoshitaka Oda,Satoshi Tanikawa,Hirokazu Sugino,Yusuke Ishida,Masumi Tsuda,Yuko Gotoda,Kunihiko Nishiwaki,Hiroyuki Yanai,Tadashi Hasegawa,Kazuo Nagashima,Shinya Tanaka
Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare tumor with low malignant potential that commonly occurs in middle age. Although more than 100 cases have been reported to date, myxoid morphology is not well documented. Here, we present a 75-yr-old woman with abnormal vaginal bleeding, with an 8-cm mass in the uterine corpus detected by irregular, high-intensity signaling on T2-weighted
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Evaluation of Histopathologic Alterations in First-trimester COVID-19-positive Pregnancies Ending in Abortion. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-14 Gültekin Adanaş Aydin,Melike Nalbant,Serhat Ünal,Serkan Tosun
This study aims to evaluate histopathologic alterations and the presence of chronic histiocytic intervillositis in first-trimester coronavirus-2019 (COVID-19)-positive pregnancies ending in abortion, compared with those at a similar gestational week and undergoing curettage before the pandemic. This retrospective case-control study consisted of 9 patients who were infected with COVID-19 and undergoing
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HER2 Status Assessment in Endometrial Serous Carcinoma: Comparative Analysis of Two Proposed Testing and Interpretation Algorithms. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-09 Sherin Hashem,Somaye Y Zare,Oluwole Fadare
HER2 status is now routinely assessed in endometrial serous carcinoma (ESC) due to the reported predictive value of HER2 protein overexpression and/or gene amplification. Herein the authors compare 2 proposed testing and interpretation guidelines for HER2 in ESC. Forty-three consecutive cases of ESC that had been dually tested by both HER2 immunohistochemistry (IHC) and fluorescence in situ hybridization
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Eccrine Porocarcinoma of the Vulva With Sarcomatoid Transformation, a New Human Papillomavirus-associated Malignancy? Case Report and Review of the Literature. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-06-09 Katelynn Campbell,Eleonora Fiorletta Quiroga,Andrew Dunn,Nicholas Zoumberos,Charles Matthew Quick
Eccrine porocarcinoma is a rare cutaneous neoplasm, and rarer still in the anogenital region. In the vulva, the most common carcinoma by far is squamous cell carcinoma; however, eccrine porocarcinoma can arise at this site. As the distinction between porocarcinoma and squamous cell carcinoma has important prognostic implications at other cutaneous sites, it stands to reason that it may have these same
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Immunohistochemical Analysis of the Tissue Factor Pathway Inhibitor-2 in Endometrial Clear Cell Carcinoma: A Single-center Retrospective Study. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-05-31 Ryuji Kawaguchi,Tomoka Maehana,Sumire Sugimoto,Naoki Kawahara,Kana Iwai,Yuki Yamada,Fuminori Kimura
The tissue factor pathway inhibitor-2 (TFPI2) was recently identified as a diagnostic serum marker for ovarian clear cell carcinoma. Moreover, the immunohistochemical expression of TFPI2 in ovarian clear cell carcinoma was recently reported. This single-center retrospective study aimed to evaluate whether TFPI2 can be a specific biomarker for immunohistological diagnosis of endometrial clear cell carcinoma
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TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-05-31 Roxanne Wadia,Austin McHenry,Rita Abi-Raad,Pei Hui
Associated with high-risk human papillomavirus infection, invasive stratified mucin-producing carcinoma is a recently characterized adenocarcinoma of the cervix. It often occurs in association with adjacent stratified mucin-producing intraepithelial lesion. Differentiated vulvar intraepithelial neoplasia and related invasive squamous cell carcinoma often arise in background vulvar lichen sclerosus
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Reconsideration of the Diagnostic Criteria for an Atypical Placental Site Nodule Comparing Typical Placental Site Nodule of the Uterus: A Report of Two Cases. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-05-31 Uiree Jo,Gi Hwan Kim,Kyu-Rae Kim
Placental site nodules (PSNs) are non-neoplastic remnants of chorionic-type intermediate trophoblastic cells from a previous gestation that form a well-defined single nodule or multiple nodules in the uterine and extrauterine sites. As the cases of PSNs transformed into gestational trophoblastic tumors were described in the literature, "atypical placental site nodules" (APSNs) have been considered
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An Expanded Series of Pilomatrix-like High-grade Endometrioid Carcinoma (PiMHEC), Including Both MMR Deficient and MMR Proficient Cases. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-05-05 Jin Xu,Kay J Park,Paul S Weisman
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Cancer Stem Cell Markers Are Differentially Expressed in Malignant Ovarian Germ Cell Tumors Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-05-05 Ben Davidson, Olesya Solheim
The objective of this study was to analyze the expression and potential clinical role of cancer stem cell (CSC) markers in malignant ovarian germ cell tumors (MOGCT). CD34, CD44, and SOX2 protein expression by immunohistochemistry was analyzed in 49 MOGCT from patients treated in Norway during the period 1980-2011. Expression was analyzed for association with tumor type and clinicopathologic parameters
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The Genomic Landscape of Vulvar Squamous Cell Carcinoma Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-05-03 Logan Corey, John J. Wallbillich, Sharon Wu, Alex Farrell, Kurt Hodges, Joanne Xiu, Chadi Nabhan, Anthony Guastella, Mira Kheil, Radhika Gogoi, Ira Winer, Sudeshna Bandyopadhyay, Marilyn Huang, Nathaniel Jones, Annelise Wilhite, Anthony Karnezis, Premal Thaker, Thomas J. Herzog, Matthew Oberley, William Michael Korn, Alex Vezina, Robert Morris, Rouba Ali-Fehmi
Vulvar squamous cell cancer (VSC) accounts for 90% of vulvar cancers. Next-generation sequencing studies of VSC imply human papillomavirus (HPV) and p53 status play separate roles in carcinogenesis and prognosis. We sought to describe the genomic landscape and analyze the immunologic profiles of VSC with respect to HPV and p53 status. A total of 443 VSC tumors underwent tumor profiling. Next-generation
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Diffuse Pediatric-type High-grade Glioma Arising in an Ovarian Mature Cystic Teratoma Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-04-13 Lena Elmuti, Julia Amundson, Elise Oberman, Aarti Kamat, Laura Sedig, Ricardo R. Lastra, Kenneth Aldape, Martha Quezado, Drew W. Pratt, Patrick J. Cimino, Zied Abdullaev, Peter Pytel, Mark A. Applebaum, Jennifer A. Bennett
Immature neuroectodermal tissue can be found in the ovary as part of an immature teratoma or as part of a teratoma with malignant neuroectodermal transformation. Such lesions may closely resemble central nervous system tumors, but their biologic similarity is unclear. We describe an 18-yr-old female who presented with abdominal pain caused by an ovarian mass with widespread metastases. Histology showed
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Diffuse Pediatric-type High-grade Glioma Arising in an Ovarian Mature Cystic Teratoma. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-04-13 Lena Elmuti,Julia Amundson,Elise Oberman,Aarti Kamat,Laura Sedig,Ricardo R Lastra,Kenneth Aldape,Martha Quezado,Drew W Pratt,Patrick J Cimino,Zied Abdullaev,Peter Pytel,Mark A Applebaum,Jennifer A Bennett
Immature neuroectodermal tissue can be found in the ovary as part of an immature teratoma or as part of a teratoma with malignant neuroectodermal transformation. Such lesions may closely resemble central nervous system tumors, but their biologic similarity is unclear. We describe an 18-yr-old female who presented with abdominal pain caused by an ovarian mass with widespread metastases. Histology showed
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FOXL2 Mutation Status in Sex Cord-stromal Tumors Cannot be Predicted by Morphology. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-04-10 Sandra Wessman,Beatriz Bohorquez Fuentes,Josefin Severin-Karlsson,Sofia Westbom-Fremer,Monica Nistér,Georgia Kokaraki,Tirzah Braz Petta,Felix Haglund,Joseph W Carlson
Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The histopathologic diagnosis of these tumors can be challenging. A recurrent somatic mutation of the forkhead box L2 (FOXL2) gene has been identified in adult GCT. In this retrospective single-center study of 44 SCST, a morphologic review together with analysis of FOXL2 C134W was evaluated in
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Uterine MEIS1::NCOA2 Fusion Sarcoma With Lung Metastasis: A Case Report and Review of the Literature Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-13 Deyin Xing, Christian F. Meyer, John M. Gross, Pedram Argani, Chien-Fu Hung, T.-C. Wu, Russell Vang, Deborah K. Armstrong, Stéphanie L. Gaillard
MEIS1::NCOA1/2 fusion sarcomas are a recently described novel entity arising in a variety of locations with a predilection for the genitourinary tract and gynecologic organs. Despite multiple locoregional recurrences, these tumors are thought to behave in a low-grade malignant manner. Here we report a uterine MEIS1::NCOA2 fusion sarcoma with lung metastasis. The patient was a 47-yr-old woman with a
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Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-13 Cindy Wepy, Marisa R. Nucci, Carlos Parra-Herran
Atypical endometriosis (A-EMS), defined by cytologic atypia and/or crowded glands resembling endometrial intraepithelial neoplasia, remains poorly understood. We aimed to refine the morphologic, immunohistochemical, and molecular features of A-EMS in an institutional series. Cases were identified through a structured search and reviewed by 2 pathologists. Immunohistochemistry and comprehensive sequencing
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Uterine MEIS1::NCOA2 Fusion Sarcoma With Lung Metastasis: A Case Report and Review of the Literature. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-13 Deyin Xing,Christian F Meyer,John M Gross,Pedram Argani,Chien-Fu Hung,T-C Wu,Russell Vang,Deborah K Armstrong,Stéphanie L Gaillard
MEIS1::NCOA1/2 fusion sarcomas are a recently described novel entity arising in a variety of locations with a predilection for the genitourinary tract and gynecologic organs. Despite multiple locoregional recurrences, these tumors are thought to behave in a low-grade malignant manner. Here we report a uterine MEIS1::NCOA2 fusion sarcoma with lung metastasis. The patient was a 47-yr-old woman with a
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Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features. Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-13 Cindy Wepy,Marisa R Nucci,Carlos Parra-Herran
Atypical endometriosis (A-EMS), defined by cytologic atypia and/or crowded glands resembling endometrial intraepithelial neoplasia, remains poorly understood. We aimed to refine the morphologic, immunohistochemical, and molecular features of A-EMS in an institutional series. Cases were identified through a structured search and reviewed by 2 pathologists. Immunohistochemistry and comprehensive sequencing
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Anastomosing Hemangioma of the Ovary With Leydig Cell Hyperplasia: A Clinicopathologic Study of 12 Cases Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Austin McHenry, Natalia Buza
Anastomosing hemangioma is a recently described vascular neoplasm, initially identified in the male genitourinary tract. Since its first description, it has been reported at multiple anatomic sites, including rare cases in the female genital tract, most in the ovary. Herein we report the largest series to date of 12 ovarian anastomosing hemangiomas identified at our institution over a 15-yr period
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Endometrioid Endometrial Carcinoma With NKX3.1 Expression in a Transgender Man: A Case Report Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-02-21 Hiroshi Yoshida, Masaya Uno, Keisuke Ogimoto, Mayumi Kobayashi-Kato, Yasuhito Tanase, Mitsuya Ishikawa, Tomoyasu Kato
Endometrial cancer in transgender men is rare, and its histopathologic features remain unknown. A 30-yr-old transgender man with an intrauterine tumor, an ovarian mass, and a 2-yr history of testosterone use was referred to us for treatment. The presence of the tumors was confirmed via imaging, and the intrauterine tumor was identified as an endometrial endometrioid carcinoma via endometrial biopsy
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Fumarate Hydratase and S-(2-Succinyl)-Cysteine Immunohistochemistry Shows Evidence of Fumarate Hydratase Deficiency in 2% of Uterine Leiomyosarcomas: A Cohort Study of 348 Tumors Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 David B. Chapel, Aarti Sharma, Livia Maccio, Emma Bragantini, Gian Franco Zannoni, Liping Yuan, Bradley J. Quade, Carlos Parra-Herran, Marisa R. Nucci
Approximately 1% to 1.5% of uterine leiomyomas are fumarate hydratase (FH)-deficient (FHd). A subset of these are associated with germline FH mutations. However, the prevalence and clinicopathologic characteristics of FHd uterine leiomyosarcoma (uLMS) remain unknown. Clinicopathologic data were collected for 348 uLMS. Morphologic features associated with FH deficiency (staghorn-type vessels, alveolar-pattern
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Leiomyoma With Massive Lymphoid Infiltration: 2 Cases With Lymphocytic Vasculopathy and Angiocentric Germinal Centers Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Jahg Wong, Simon F. Roy, Diane Provencher, Antonio Maietta, Kurosh Rahimi
Uterine leiomyoma with massive lymphoid infiltration is characterized by a dense lymphoid infiltrate and germinal centers sparing the adjacent myometrium. Only few reports describe this entity and its etiology is unknown. This rare lesion may also exhibit lymphocytic vasculopathy but this has only been reported in the setting of GnRH agonist exposure. We report 2 cases of uterine leiomyoma with massive
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Evaluation of Saccharomyces cerevisiae–like 1 (SEC14L1) in Gynecologic Malignancies Shows Overexpression in Endometrial Serous Carcinoma Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Natalie Banet, Max Masnick, M. Ruhul Quddus
Saccharomyces cerevisiae–like 1 (SEC14L1) is a member of the SEC14 family and is involved in liposoluble vitamin transfer, and in a large cohort of breast cancer cases, was one of the genes most significantly associated with lymphovascular invasion (LVI), and had a significant relationship with human epidermal growth factor receptor 2 status, survival, and histologic grade. In this study, 111 separate
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COL1A1-PDGFB Fusion Associated Fibrosarcoma of the Uterine Corpus: A Case Report and Literature Review Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Vandana Panwar, Yu Liu, Katja Gwin, Hao Chen
Uterine collagen type 1 alpha 1 (COL1A1) and platelet-derived growth factor beta chain (PDGFB) fusion associated fibrosarcoma is a recently described entity characterized by a specific translocation t(17;22) (q22;q13) leading to the formation of COL1A1-PDGFB fusion transcripts that are typically associated with dermatofibrosarcoma protuberans. So far, only 4 cases of COL1A1-PDGFB fusion associated
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A Case of COL1A1-PDGFB Fusion Uterine Sarcoma Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Adriana Hogeboom, Carmen Bárcena, Lucía Parrilla-Rubio, Enrique Revilla, Yolanda Ruano, Irene Gallego-Gutiérrez, Mario Martínez-López
COL1A1-PDGFB gene fusion uterine sarcoma is a recently described entity which shows some overlapping features with dermatofibrosarcoma protuberans. To date, only 4 cases have been reported in the literature. Due to its rarity, succinct clinicopathologic characteristics are yet to be established. We report a fifth case initially mistaken as a uterine fibroid which histologically proved to be a CD34+
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Metastatic Uterine Leiomyosarcoma With Rhabdomyosarcomatous Heterologous Differentiation Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Baris Boyraz, Tasos Gogakos, Kevin A. Raskin, Gunnlaugur Petur Nielsen
Heterologous differentiation has only been previously reported twice in metastatic uterine leiomyosarcomas. We report herein the first case of metastatic uterine leiomyosarcoma with rhabdomyosarcomatous differentiation. A 67-yr-old woman presented with femur, abductor magnus, and lymph node metastases 9 yr after the primary diagnosis. The metastatic sites showed rhabdomyosarcomatous morphologic features
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BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma Int. J. Gynecol. Pathol. (IF 2.4) Pub Date : 2023-03-01 Kyle M. Devins, Lawrence Zukerberg, Jaclyn C. Watkins, Yin Pun Hung, Esther Oliva
Peritoneal mesothelioma (PM) and serous neoplasms can be difficult to differentiate, particularly in small biopsies. BRCA1-associated protein 1 (BAP1) is expressed in benign tissues, but over 50% of PMs demonstrate complete loss of nuclear expression. Claudin-4, a tight junction protein, is expressed in most epithelial tumors but not in mesotheliomas. Methylthioadenosine phosphorylase (MTAP) is frequently