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Enduring Consensus Guidelines for Cervical Cancer Screening and Management: Introduction to the Scope and Process. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-03-06 Nicolas Wentzensen, Francisco Garcia, Megan A Clarke, L Stewart Massad, Li C Cheung, Didem Egemen, Richard Guido, Warner Huh, Debbie Saslow, Robert A Smith, Elizabeth R Unger, Rebecca B Perkins
The Enduring Consensus Cervical Cancer Screening and Management Guidelines (Enduring Guidelines) effort is a standing committee to continuously evaluate new technologies and approaches to cervical cancer screening, management, and surveillance.
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Recommendations for Use of p16/Ki67 Dual Stain for Management of Individuals Testing Positive for Human Papillomavirus. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-03-06 Megan A Clarke, Nicolas Wentzensen, Rebecca B Perkins, Francisco Garcia, Deborah Arrindell, David Chelmow, Li C Cheung, Teresa M Darragh, Didem Egemen, Richard Guido, Warner Huh, Alexander Locke, Thomas S Lorey, Ritu Nayar, Carolann Risley, Debbie Saslow, Robert A Smith, Elizabeth R Unger, L Stewart Massad
The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for dual stain (DS) testing with CINtec PLUS Cytology for use of DS to triage high-risk human papillomavirus (HPV)-positive results.
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Performance of Different Follow-Up Strategies and Genotype-Based Recurrence Risk After Treatment of Cervical High-Grade Squamous Intraepithelial Lesion. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-03-05 Joana Graça, Mario Preti, Benedetta Pollano, Pedro Vieira-Baptista
Our aim was to evaluate the performance of different follow-up strategies after treatment for cervical intraepithelial neoplasia (CIN) 2 or 3, including human papillomavirus (HPV) detection, cytology, or colposcopy, as well as their combinations. Additionally, we compared the influence of the persistence of HPV 16/18 versus that of other high-risk HPV genotypes (HR-HPV) in the recurrence risk.
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Awareness Level of Cervical Cancer Patients Referred to Radiation Oncology Outpatient Clinics-A Multicenter Study. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-03-05 Pelin Altinok, Şefika Arzu Ergen, Zeliha Güzelöz Çapar, Emine Canyilmaz, Züleyha Akgün, Meltem Serin, Canan Akbaş, Meryem Aktan, Eda Erdiş, Hilal Kiziltunç Özmen, Enis Özyar, Ahmetcan Çağlar, Filiz Munzuroğlu Ak, Mehmet Fatih Akyüz, Ayşe Altinok
The study aimed to assess the level of knowledge of patients with cervical cancer referred to radiation oncology outpatient clinics in Turkey regarding screening methods and human papillomavirus (HPV) vaccination and increase social awareness based on the findings.
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Topical Corticosteroid Phobia Among Women Affected With Vulvar Lichen Sclerosus: Results From a Cross-sectional Survey. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-02-12 Alessandro Borghi, Maria Elena Flacco, Lucrezia Pacetti, Giulia Toni, Monica Corazza
Topical corticosteroid (TC) phobia (TCP) is common in subjects affected with chronic inflammatory skin diseases who need prolonged corticosteroid treatments. The aim of this study was to assess TCP in women affected with vulvar lichen sclerosus (VLS).
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Relationship Between Childhood Sexual Abuse, Obesity, and Vulvodynia in Adulthood. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-02-12 Rachel B Blaustein, Christine A Parker, Hope K Haefner, Barbara D Reed, Jessica K Haefner, Kathryn C Welch
The aim of the study is to assess the relationship between childhood sexual abuse, obesity, and vulvodynia among adult women participating in a population-based longitudinal vulvodynia study.
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Adenocarcinoma In Situ of the Uterine Cervix (AIS) Treated by Loop Electrosurgical Excision Procedure Strategy: An Observational Study. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2024-01-16 Erik Soegaard-Andersen, Anna Poulsgaard Frandsen, Preben Sandahl
Evaluation of the results of treatment of adenocarcinoma in situ by loop electrosurgical excision procedure and the safety of a conservative strategy.
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2019 ASCCP Risk-Based Management Consensus Guidelines: Updates Through 2023. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-12-20 Rebecca B Perkins, Richard S Guido, Philip E Castle, David Chelmow, Mark H Einstein, Francisco Garcia, Warner K Huh, Jane J Kim, Anna-Barbara Moscicki, Ritu Nayar, Mona Saraiya, George F Sawaya, Nicolas Wentzensen, Mark Schiffman
This Research Letter summarizes all updates to the 2019 Guidelines through September 2023, including: endorsement of the 2021 Opportunistic Infections guidelines for HIV+ or immunosuppressed patients; clarification of use of human papillomavirus testing alone for patients undergoing observation for cervical intraepithelial neoplasia 2; revision of unsatisfactory cytology management; clarification that
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Unusual Presentation of Lymphangioma Circumscriptum of the Vulva: In Association With Crohn Disease. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-12-20 Ana Calhau, Rita Salgueiro Neto, Rita Leiria Gomes, Tânia Freitas, Isabel Oliveira
Lymphangioma circumscriptum (LC) is a rare benign condition, with marked dilation of surface lymphatic vessels in the deep and subcutaneous layers. Vulvar LC can become a highly disabling condition with vulvar discomfort, itching, burning and lymph seeping being the dominant symptoms. Biopsy is mandatory for the diagnosis. There is no consensus on the standard treatment for vulvar LC and recurrence
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Clinical Characteristics and Detection Sensitivity of Cervical Cancer Screening in Vaginal Intraepithelial Neoplasia. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-12-18 Yusha Chen, Qiaoyun Chen, Huifeng Xue, Jinwen Zheng, Jiancui Chen, Xiangqin Zheng
This study aimed to investigate the characteristics and screening history of vaginal intraepithelial neoplasia (VaIN) or vaginal cancer and compare the sensitivity of cytology and human papillomavirus (HPV) tests on the cervix against vaginal and cervical high-grade squamous intraepithelial lesion or cancer.
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Dequalinium Chloride for the Treatment of Vulvovaginal Infections: A Systematic Review and Meta-Analysis. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-12-07 Fanny Eckel, Alex Farr, Julia Deinsberger, Karin Kernmayer-Farr, Philipp Foessleitner
Women at reproductive age frequently experience vulvovaginal infections and vaginitis. The most common etiologies are vulvovaginal candidiasis (VVC), bacterial vaginosis (BV), desquamative inflammatory vaginitis/aerobic vaginitis, and trichomoniasis. Various treatment options are available for these infections, such as specific antimicrobial or antiseptic agents. Dequalinium chloride (DQC) is a local
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Lugol's Solution Reduces Positive Margins and Residual Disease After the Large Loop Excision of Transformation Zone. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-27 Min-Jeong Kim, Grace J Lee, Eun Ji Lee, Seungmee Lee, Doo Byung Chay, Chae Hyeong Lee, Jae-Hoon Kim, Ju-Won Roh
This study aimed to examine whether the intraoperative use of Lugol's solution reduces the proportion of positive resection margins (RMs) using the data of women who underwent large loop excision of the transformation zone (LLETZ).
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Agreement on Lesion Presence and Location at Colposcopy. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-13 Kathrine Dyhr Lycke, Jayashree Kalpathy-Cramer, Jose Jeronimo, Silvia de Sanjose, Didem Egemen, Marta Del Pino, Jenna Marcus, Mark Schiffman, Anne Hammer
The reproducibility and sensitivity of image-based colposcopy is low, but agreement on lesion presence and location remains to be explored. Here, we investigate the interobserver agreement on lesions on colposcopic images by evaluating and comparing marked lesions on digitized colposcopic images between colposcopists.
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Is Vulvodynia Associated With an Altered Vaginal Microbiota?: A Systematic Review. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-13 Koray Gorkem Sacinti, Hosna Razeghian, Yaseen Awad-Igbaria, Joana Lima-Silva, Eilam Palzur, Pedro Vieira-Baptista, Hans Verstraelen, Jacob Bornstein
Vulvodynia is defined as vulvar pain of at least 3 months' duration, without clear identifiable cause, which may have potential associated factors. It can have a significant impact on women's quality of life due to a combination of physical pain, emotional distress, and limited treatment options. Despite affecting a considerable number of women worldwide, the causes and underlying mechanisms of vulvodynia
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Colposcopy-A Valuable Diagnostic Tool for Pregnant Women With Unexplained Vaginal Bleeding. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-10 Inshirah Sgayer, Maskit Shmueli, Lior Lowenstein, Maya Frank Wolf
We aimed to examine the diagnostic value of colposcopy in a large cohort of pregnant women with unexplained vaginal bleeding during the second or third trimester.
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The International Society for the Study of Vulvovaginal Disease (ISSVD) Vulvar Awareness Day Campaign: Knowledge of Vulvovaginal Diseases Among Italian Obstetrics and Gynecology Residents. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-08 Federica Bevilacqua,Amanda Selk,Colleen Stockdale,Pedro Vieira-Baptista,Tolu Adedipe,Tanja Bohl,Luca Marozio,Fulvio Borella,Niccolò Gallio,Benedetta Pollano,Eleonora Robba,Ilaria Barbierato,Chiara Benedetto,Mario Preti
OBJECTIVES The objective of this study is to investigate vulvovaginal disease (VVD) awareness in Italian obstetrics and gynecology (Ob/Gyn) residents. MATERIALS AND METHODS A 25-question survey on VVD basic knowledge (17 questions) and willingness to improve it (8 questions) was distributed through Ob/Gyn resident online group chats, from different Italian Universities in January 2023. A total number
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Efficacy of Physiotherapy for Treating Vulvodynia: A Systematic Review. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-07 Renata Polliana Nascimento,Megan L Falsetta,Tracey Maurer,Ayane Cristine Alves Sarmento,Ana Katherine Gonçalves
OBJECTIVES We set out to assess the efficacy of physiotherapy for vulvodynia. MATERIALS AND METHODS PubMed, Embase, Scopus, Web of Science, SciELO, PEDro, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched in February 2023. Two authors selected and extracted the data independently. The risk of bias was assessed using the Cochrane Risk of Bias tool (Rob 2). Because
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Aesthetic Outcome and Psychosexual Distress After Treatment for Vulvar High-Grade Squamous Intraepithelial Lesions. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-07 Gerda Trutnovsky,Magdalena Holter,Daniela Gold,Daisy Kopera,Julia Deban,Dina Misut,Stefanie Aust,Karl Tamussino,Elfriede Greimel
OBJECTIVES This study compared aesthetic outcome, psychosexual distress, and treatment satisfaction between women receiving surgical treatment or medical treatment with imiquimod for vulvar high-grade squamous intraepithelial lesion. MATERIALS AND METHODS This is an extended analysis of the multicenter, randomized noninferiority trial "topical imiquimod versus surgery for vulvar intraepithelial neoplasia
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Recurrence After Biopsy-Confirmed Cervical High-Grade Intraepithelial Lesion Followed by Negative Conization: A Systematic Review and Meta-analysis. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-04 David Viveros-Carreño,Nathalia Mora-Soto,Juliana Rodríguez,José Alejandro Rauh-Hain,Pedro T Ramírez,Melissa López Varón,Kate J Krause,Carlos Fernando Grillo-Ardila,Jose Jeronimo,René Pareja
ABSTRACT The aim of the study is to assess the recurrence rate (as cervical intraepithelial neoplasia 2+ [CIN2+]) in patients who had a confirmed high-grade squamous intraepithelial lesion (CIN2-3) in a cervical biopsy specimen followed by a negative conization specimen. MATERIALS AND METHODS A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews
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Systemic Therapy for Lichen Sclerosus: A Systematic Review. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-04 Abby Hargis,Madeline Ngo,Christina N Kraus,Melissa Mauskar
BACKGROUND Lichen sclerosus (LS) is a chronic, inflammatory process affecting predominantly anogenital skin, with extragenital involvement in up to 20% of cases. The mainstay of therapy for anogenital LS is topical immunosuppression. However, in treatment-refractory cases, severe, or hypertrophic disease, systemic modalities may be used. Currently, there are no guidelines for systemic therapy in LS
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A Comparison of Lichen Sclerosus and Vulvodynia Content Across Social Media Platforms: What Is Trending Over Time. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-04 Samantha Shiplo,Brintha Sivajohan,Amanda Selk
OBJECTIVES Vulvovaginal diseases are common gynecologic complaints and patients often turn to social media (SM) for medical information. The objective of this study is to examine vulvovaginal content on SM and how it has changed over time. MATERIALS AND METHODS Four SM platforms were searched (i.e., Facebook, Instagram, Twitter, and YouTube) at 2 time points from March 30 to May 7, 2021, and again
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An Alternative to Cytology in Triaging Cisgender Men and Transgender Women With HIV for High-Resolution Anoscopy. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-03 Shane M Mudrinich, Minh Ly T Nguyen, Danielle M Blemur, Xinzhu Wang, Yun F Wang, Uma Krishnamurti, Marina Mosunjac, Lisa C Flowers
To evaluate high-risk human papillomavirus testing (hrHPV) as an alternative for anal cytology in screening for high-grade anal neoplasia (AIN2-3) among males with HIV. To identify predictive risk factors for AIN2-3 and develop a clinical tool to triage males with HIV for high-resolution anoscopy (HRA) without cytology.
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A Case of Basaloid Differentiated Vulvar Intraepithelial Neoplasia. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-03 Courtney L O'Keefe,Luisa Y A Watts,Jill I Allbritton
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Attitudes About the Human Papillomavirus Vaccine Among Patients With and Without Cervical Dysplasia. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-11-03 Allison L Swiecki-Sikora,Abigail Lauder,Adina Harris,Erin K Tagai,Mengying Deng,Stacey L Jeronis,Karen L Houck,Suzanne M Miller,Enrique Hernandez
OBJECTIVES The aims of the study are to examine the perception of the human papillomavirus (HPV) vaccine among those with and without a history of cervical dysplasia and to examine perceptions of the vaccine for their children. MATERIALS AND METHODS Patients were recruited to complete a survey about the HPV vaccine for both themselves and their children. Patients in a colposcopy clinic with a history
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Defining the Longitudinal Risk of CIN 3+ for J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-10-30 Sabrina Piedimonte,Kyle Tsang,Nathaniel Jembere,Joan Murphy,Tina Karapetian,Julia Gao,Bronwen McCurdy,Jocelyn Sacco,Rachel Kupets
OBJECTIVE To determine the baseline and cumulative risk of cervical intraepithelial neoplasia (CIN)3 and invasive cervical cancer in participants referred to colposcopy with high-grade cytology and
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Vulvar Ulcers: An Algorithm to Assist With Diagnosis and Treatment. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-10-30 Natalie A Saunders,Kathryn C Welch,Hope K Haefner,Cindy Rasmussen,Lynne Margesson
OBJECTIVES Vulvar ulcers can be challenging to diagnose, manage, and treat. Ulcers can be nonspecific in appearance and have many etiologies. Description of the lesion is very important. METHODS An interactive vulvar ulcer algorithm was created to aid in the evaluation, diagnosis, and treatment of vulvar ulcers. RESULTS The algorithm flowchart begins with careful history and physical examination. Pending
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Women 50 Years and Older With Negative Pap Test and Positive Human Papillomavirus Test for Genotypes Other Than 16 and 18-Follow-up Outcomes. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-10-30 Farah S Baban,Michael R Henry,Margaret E Long,Meredith A VandeHaar,Grant M Spears,Sarah M Jenkins,Diva R Salomao
OBJECTIVE A follow-up of women 50 years or older with concomitant positive high-risk human papillomavirus (HPV) genotypes other than 16 and 18 (hrHPVO) and negative Pap test (NILMPap) was conducted to better understand the implications of hrHPVO positivity on potential risk of developing significant high-grade lesions. MATERIAL AND METHODS A retrospective review of 2014 cytology data of patients with
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Commentary on New Guidance for Human Papillomavirus-Related Cancer Screening Among Sexual and Gender Minority Populations. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-10-01 Sarah S Jackson,Karen L Parker
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More Steps Forward for the Journal of Lower Genital Tract Disease. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-09-20 Jacob Bornstein
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Understanding Sexual and Gender Minority Populations and Organ-Based Screening Recommendations for Human Papillomavirus-Related Cancers. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-9-20 Dominique Jodry, Juno Obedin-Maliver, Lisa Flowers, Naomi Jay, Serina Floyd, Deanna Teoh, Christine Conageski, Levi Downs, Michelle J Khan
Sexual gender minority (SGM) populations are at risk for human papillomavirus (HPV)-related cancers of the anogenital tract and oropharynx and often face barriers to health care. The goals of this document are to clarify language to provide inclusive care for SGM populations and to provide recommendations for screening and prevention of HPV-related cancers in SGM populations.
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Incidence of Vulvar Lichen Sclerosus and of Cancer Among Vulvar Lichen Sclerosus Patients: Does Socioeconomic Status Have a Role? J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-9-20 Alessandro Borghi, Stefano Ferretti, Lucrezia Pacetti, Fabio Falcini, Monica Corazza
Socioeconomic status (SES) impacts on the incidence of many inflammatory diseases and cancers, but there is no evidence on its implication in vulvar lichen sclerosus (VLS). The authors aimed to assess possible associations between SES and both occurrence of VLS and cancer occurrence among VLS patients.
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Comorbidities in Male Patients With Lichen Sclerosus: A Case-Control Study. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-9-20 Niina K Hieta, Marjut A M Haataja, Lotta Tapana
Lichen sclerosus (LS) is a chronic inflammatory skin disease. In male patients, it usually involves the glans penis and foreskin and can cause phimosis or meatal stenosis. The aim of this cross-sectional case-control study was to identify clinically important comorbidities in male patients with LS.
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Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-9-20 Jeanne Wendling, Françoise Plantier, Micheline Moyal-Barracco
The etiology of plasma cell vulvitis (PCV) is debated. The authors aimed to test the hypothesis that PCV could be divided into 2 clinical phenotypes.
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"Check Your Vulva"-A Patient Education and Virtual Vulva Care Pilot Project. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-9-20 Amanda Selk, Praniya Elangainesan, Evan Tannenbaum, Karen Wong
The aim of the study is to identify whether vulvar self-examination learned from a web site could lead to a self-identification of vulvar lesions and the feasibility of virtual vulvar care with patient submitted photos.
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Truth or DARE (Digital Anal Rectal Examination): Gynecologist Viewpoints on Anal Cancer Screening. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-08-16 Laura M Gaydos,Danielle Blemur,Tahira Perry,Elizabeth A Stier,Michelle J Khan,Lisa Flowers
METHODS The authors conducted a survey for practicing gynecologists recruited through academic institutions, professional societies, and professional groups on social media resulting in 196 respondents. The survey, fielded between January and June 2022, included questions on knowledge, attitudes, training, and practices regarding anal cancer prevention (ACP). Descriptive statistics and χ 2 analysis
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Triage Value of Cervical Exfoliated Cell DNA Ploidy Analysis in Cervical High-Risk Human Papillomavirus-Positive Women. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-08-16 Boliang Chu,Jie Dong,Yingying Chen,Xiaofang Ru,Wenwen Zhang,Yun Chen,Xiaoxing Zhang,Xiaodong Cheng
OBJECTIVE This study aimed to investigate the triage value obtained in DNA ploidy analysis of cervical exfoliated cells in women with high-risk human papillomavirus (HR-HPV)-positive status in the primary screening of cervical cancer. METHODS The authors selected 3,000 HR-HPV-positive women for cervical exfoliated cell sampling and conducted DNA ploidy analysis, liquid-based cytology (LBC), colposcopy
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Fat Grafting in Vulvar Lichen Sclerosus: Long Term Follow-Up. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-08-08 Veronica Boero, Massimiliano Brambilla, Eugenia Di Loreto, Giulia Emily Cetera, Sonia Cipriani, Francesca Boggio, Ermelinda Monti, Giada Libutti, Carlotta Caia, Fabio Parazzini
The rationale for the use of autologous fat grafting in the treatment of vulvar lichen sclerosus (VLS) consists in reduction of inflammation, regeneration of tissues, volume increase, and pain fiber control. The main outcome of our study was the evaluation of patients' satisfaction after treatment. Secondary outcomes included modifications in symptoms, psychosexual wellbeing, vulvar hydration, and
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Psychological Distress in Women With Abnormal Pap Smear Results Attending Cervical Cancer Screening. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-08-03 Irena Ilic, Goran Babic, Aleksandra Dimitrijevic, Sandra Sipetic Grujicic, Milena Ilic
Women often experience psychological distress upon receipt of an abnormal Pap test result. This study aimed to evaluate psychological distress and its correlates among women who received an abnormal Pap screening test result.
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Opportunities Missed: Cervix Cancer Screening Failures in Women Aged 65 and Older. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-07-19 Brandon I Ing,Marla E Scott,Scott E Lentz
OBJECTIVES This study aimed to determine the screening history and associated outcomes of women diagnosed with cervical cancer after age 65. METHODS All patients from 2012 to 2021 diagnosed with squamous, adenocarcinoma, neuroendocrine, or adenosquamous cervical cancer after age 65 in a single managed care organization (MCO) were included in this retrospective cohort study. Demographic, medical, screening
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Nonsclerotic Lichen Sclerosus: Definition of a Concept and Pathologic Description. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-07-19 Tania Day,M Angelica Selim,Jill I Allbritton,James Scurry,
OBJECTIVE Nonsclerotic lichen sclerosus (NSLS) refers to the clinicopathologic situation of examination findings consistent with lichen sclerosus (LS) but without dermal sclerosis on microscopy. This review aims to describe the features of NSLS and provide a classification framework. METHODS The International Society of the Study of Vulvovaginal Diseases tasked the Difficult Pathologic Diagnoses Committee
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Future Directions for Research on Anal Precancerous Lesion Treatment. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-07-19 Andreia Albuquerque
The benefit of treating anal precancerous lesions to reduce anal cancer progression was recently shown in people living with HIV. This will certainly impact the future development of recommendations on anal cancer prevention by including anal precancerous lesions screening and treatment for people living with HIV. However, by bringing this topic to the spotlight, it has also uncovered data that are
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Vulvar and Vaginal Graft Versus Host Disease After Allogeneic Stem Cell Transplant-A Systematic Review. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-6-28 Marta Preston, Anthony Richards
To conduct a systematic literature search to identify and determine the prevalence, signs and symptoms, and clinical management of vulvar and vaginal graft versus host disease (GVHD).
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The Association Between Female Genital Schistosomiasis and Other Infections of the Lower Genital Tract in Adolescent Girls and Young Women: A Cross-Sectional Study in South Africa. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-6-28 Jilna Dilip Shukla, Elisabeth Kleppa, Sigve Holmen, Patricia D Ndhlovu, Andile Mtshali, Motshedisi Sebitloane, Birgitte Jyding Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun Floerecke Kjetland
This study aimed to explore the relationship between female genital schistosomiasis (FGS), sexually transmitted infections, bacterial vaginosis, and yeast among young women living in Schistosoma haematobium-endemic areas.
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Does the New National Cervical Screening Programme Guideline Detect Cases of High-Grade Squamous Intraepithelial Lesions That Previously Would Have Been Missed? J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-6-28 Jennifer C Pontré, Elizabeth Nathan, Hilary Goldsmith, Bernadette McElhinney
The aim of this study was to determine the number of patients undergoing large loop excision of the transformation zone (LLETZ), for biopsy-confirmed high-grade squamous intraepithelial lesions (HSIL), where the original cervical screening test (CST) reported oncogenic human papillomavirus (HPV) and negative liquid-based cytology (LBC). This reflects the number of patients where a LLETZ procedure would
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Recurrent High-Grade Squamous Intraepithelial Lesion After Loop Excision Procedure Versus Loop Procedure With Top Hat. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-06-06 Alex A Francoeur, Katelyn B Furey, Juan Ramirez, Alexandra M Klomhaus, Christine Holschneider, Lisa M Garcia
To evaluate single-pass loop electrosurgical excision procedure (LEEP-SP) versus LEEP with top hat (LEEP-TH) in terms of treatment failure defined as high-grade squamous intraepithelial lesion (HSIL) cytology within 2 years' follow-up.
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Steroid Phobia in Patients With Vulvar Lichen Sclerosus. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-06-06 Emily Delpero, Abi Sriharan, Amanda Selk
Steroid phobia in people with dermatologic conditions is associated with noncompliance with topical corticosteroids (TCS). Although it has not been studied in those with vulvar lichen sclerosus (vLS), first-line therapy is lifelong maintenance TCS, and noncompliance is associated with impaired quality of life, progression of architecture changes, and vulvar skin cancer. The authors aimed to measure
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Multiple Vulvar Polyps in Pregnancy: A Benign Disease With a Challenging Diagnosis. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-17 Vincenzo Pinto,Miriam Dellino,Rossana Cicinelli,Leonardo Micheletti,Giuseppe Ingravallo,Gerardo Cazzato,Eliano Cascardi,Ettore Cicinelli
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Demonstrating a Statistically Significant Association Between Anal High-Grade Squamous Intraepithelial Lesion and Positive OncoE6 Anal Test in Men Who Have Sex With Men and are Living With HIV. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-17 Jeanne A Jordan, Karina I Rivas, Annette Aldous, Kaleigh A Connors, Kamwing Jair, David A Klein, Elizabeth S Hoke, Stephen E Abbott
The aim of the study is to determine whether a positive OncoE6 Anal Test result has statistically significant higher odds of being associated with high-grade squamous intraepithelial lesion (HSIL) and to calculate sensitivity and specificity of this test for predicting HSIL in adult men who have sex with men and are living with HIV (MSMLWH).
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Nocturnal Vulval Pain in Girls-A Subset of Vulvodynia? J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-17 Manpreet K Sagoo, Manpreet Lakhan, Micheline Moyal-Barracco, Fiona M Lewis
The aims of our case series were to outline the clinical features of prepubertal nocturnal vulval pain syndrome and to look at management and outcomes.
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Influence of General and Local Anesthesia on Postoperative Pain After a Loop Electrosurgical Excision Procedure. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-17 Kemal Güngördük,Hilal Ezgi Türkmen,Varol Gülseren,Berfin Küçükler,Özgü Çelikkol,İsa Aykut Özdemir
OBJECTIVE To compare patient satisfaction, histopathologic results, and short-term morbidity in patients undergoing loop electrosurgical excision procedure (LEEP) under local anesthesia (LA) versus general anesthesia (GA). METHODS Participants who met the inclusion criteria were randomly allocated in a 1:1 ratio to the LA group or GA group. Pain was determined by both objective (faces pain scale-revised)
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Neovaginoplasty With Nile Tilapia Skin: Cytological and Microbiota Evaluation. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-17 Cristiana Rodrigues Teófilo,Raquel Autran Coelho Peixoto,Renata Mirian Nunes Eleutério,Edmar Maciel Lima Junior,Manoel Odorico de Moraes Filho,Leonardo Robson Pinheiro Sobreira Bezerra,Zenilda Vieira Bruno
OBJECTIVES To study the clinical, cytological, and vaginal microbiota findings in patients with Mayer-Rokitansky-Küster-Hauser syndrome who underwent neovaginoplasty using Nile tilapia fish skin. METHODS This is a cross-sectional study with 7 cisgender women with Mayer-Rokitansky-Küster-Hauser syndrome who had previously undergone neovagina reconstruction using Nile tilapia fish skin at a university
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Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma: Updates From the Last 3 Years. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-11 Andreia Albuquerque
In the last 3 years, new and relevant information has been published on anal cancer and anal precancerous lesions epidemiology, screening, treatment, and vaccination. This information will likely change prevention and treatment strategies for these patients in the upcoming years.
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Virtual Reality for Anxiety Reduction in Women Undergoing Colposcopy: A Randomized Controlled Trial. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-11 Julia M Hecken, Pia Halagiera, Sadia Rehman, Clemens B Tempfer, Günther A Rezniczek
To test whether headset-delivered virtual reality (VR) content affects satisfaction and/or anxiety in women with cervical squamous intraepithelial lesions undergoing colposcopy and colposcopically guided cervical biopsy.
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Optical Coherence Tomography Can Reduce Colposcopic Referral Rates in Patients With High-Risk Human Papillomavirus. J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-05-04 Xiao Xiao, Lei Yan, Xue Yang, Zhixian Zhou, Liye Shi, Chun Fu
This study aimed to evaluate the feasibility of combined human papillomavirus (HPV) and optical coherence tomography (OCT) cervical cancer screening strategies.
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Cervical Cancer Screening in Women Aged Older Than 65 Years J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-04-25 Serap Fırtına Tuncer, Hasan Aykut Tuncer
Objectives Considerable debate exists among guidelines regarding when cervical cancer screening can be safely stopped. We aimed to compare the efficiency of human papillomavirus (HPV) test, cytology, and previous screening history for the diagnosis of cervical intraepithelial neoplasia (CIN) 2+ lesions in women aged older than 65 years. Materials and Methods This is a retrospective cohort study.
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Cost-Conscious Colposcopy: A Single-Institution Review of Biopsy Submission Practices and Outcomes J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-04-24 Ian C. Cook, Laura I. Fuhr, Sarah E. Flores, Wendy M. Novicoff, Leigh A. Cantrell
Objective Distribution of cervical dysplasia may influence approach for excisional procedures. Separating colposcopy biopsies into multiple specimen cups for pathologic evaluation incurs additional costs. We aimed to determine if the practice of separating biopsy specimens impacts patient outcomes. Methods A retrospective review of all colposcopy cases from a single institution was performed. A total
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Utility of Extended HPV Genotyping as Primary Cervical Screen in an Unscreened Population With High HIV Co-Infection J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-04-24 Matthys H. Botha, Frederick H. Van der Merwe, Leon C. Snyman, Gerrit J. Dreyer, Cathy Visser, Greta Dreyer
Objective Screening with primary human papillomavirus (HPV) testing has been evaluated in highly prescreened populations with lower HPV and HIV prevalence than what is the case in South Africa. High prevalence of HPV and underlying precancer in women living with HIV (WLWH) affect the clinical performance of screening tests significantly. This study investigates the utility and performance of an extended
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Alpha, Beta and Gamma Human Papillomaviruses in Genital Lichen Sclerosus: A Retrospective Cross-Sectional Study J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-04-13 Eugenia Giuliani, Francesca Rollo, Carlo Cota, Tarik Gheit, Luisa Galati, Sandrine McKay-Chopin, Marinella Tedesco, Emilia Migliano, Maria Benevolo, Aldo Morrone, Maria Gabriella Donà, Alessandra Latini
Background Lichen sclerosus (LS) is an inflammatory disease mostly arising at the genital level. It is unclear whether human papillomaviruses (HPVs) have an etiological significance in LS, and data on their prevalence in patients with LS are controversial. Objectives We assessed alpha, beta, and gamma HPV prevalence in patients with genital LS. The association of HPV positivity with demographic and
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Cervical Stenosis After Conization Associated With False-Negative Human Papillomavirus-Based Post-Treatment Testing J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-04-11 Linda Ruth Harris
Complete cervical stenosis after cold-knife conization resulted in false-negative human papillomavirus-based follow-up tests and delayed diagnosis of invasive squamous cell carcinoma.
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Milk and Dairy Consumption and Its Relationship With Abundance of Lactobacillus crispatus in the Vaginal Microbiota: Milk Intake and Vaginal Lactobacillus J. Lower Genit. Tract Dis. (IF 3.7) Pub Date : 2023-04-11 Gabriela B. Moura, Márcia G. Silva, Camila Marconi
Objectives Diet habits, such as low milk and dairy intake, have been associated with bacterial vaginosis. Thus, we compared vaginal Lactobacillus crispatus abundances in women with different molecularly defined community state types (CSTs) according to the consumption of milk and/or dairy products. Methods A total of 516 women from the 5 geographic regions of Brazil were included. Participants were