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Rural residence and health-related quality of life in a sample of Spain perimenopausal women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-17 Cristina Llaneza-Suarez, Paz Garcia-Portilla, Beatriz Rodriguez-Vijande, Julia Carriles, Manuel Sánchez-Prieto, Pluvio J. Coronado Martín, Ángel Plácido Llaneza Coto, Rafael Sánchez-Borrego
The prevalence and severity of perimenopausal symptoms are typically associated with multiple factors, including demographic characteristics. The sociodemographic characteristics of women living in...
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Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-15 Alessandro D. Genazzani, Christian Battipaglia, Laura Rusce, Greta Prampolini, Claudia Aio, Francesco Ricciardiello, Martina Foschi, Alessandra Sponzilli, Elisa Semprini, Tabatha Petrillo
To evaluate the effects of alpha lipoic acid (ALA) on hormonal and metabolic parameters in a group of overweight/obese Polycystic Ovary Syndrome (PCOS) patients.This was a retrospective study in wh...
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Correlation between anti-müllerian hormone in polycystic ovarian syndrome with metformin: a systematic review and meta-analysis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-13 Hongcen Liu, Li Mo, Xiaofang Tian, Shizhen Fan, Jiayi Hu, Lin Zhang, Bohai Yu
This study aims to examine the short-term effects of oral metformin (MET) on serum anti-müllerian hormone (AMH) levels and to verify its impact on AMH concentrations in women with polycystic ovary ...
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Possible association between subclinical hypothyroidism and age at menopause in Colombian women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-08 Álvaro Monterrosa-Castro, Angelica Monterrosa-Blanco, Sandra Sánchez-Zarza
To evaluate the association between subclinical hypothyroidism with early menopause, premature menopause, and last menstrual bleeding before the natural age of menopause.This was a cross-sectional ...
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Statement of Retraction: The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-08
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Long-term treatment for endometriosis with dienogest: efficacy, side effects and tolerability Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-05 Francesco La Torre, Silvia Vannuccini, Federico Toscano, Ernesto Gallucci, Gretha Orlandi, Virginia Manzi, Felice Petraglia
Dienogest (DNG) improves endometriosis-associated pain (EAP) and patients’ quality of life; however, the modern cornerstone of the management of endometriosis is the long-term adherence of the pati...
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Postmenopausal women with higher TSH values within the normal range present improved handgrip strength: a pilot study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-03 Panagiota Chatzivasileiou, Eleni Armeni, Peter Chedraui, Loraina Kontou, Areti Augoulea, Anastasia Palaiologou, George Kaparos, Konstantinos Panoulis, Andreas Alexandrou, Nikolaos Vlachos, Irene Lambrinoudaki
To evaluate the possible association between thyroid function within the euthyroid range and musculoskeletal parameters as well as body composition in a sample of postmenopausal women.This cross-se...
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Menopausal symptoms and the awareness of menopausal-related information in low-income mid-aged women from Guayaquil, Ecuador Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-04-02 Danny Salazar-Pousada, Valeria Ortega-Uscocovich, Cecibel Ramírez-Morán, Peter Chedraui
To assess menopausal symptoms and determine awareness of menopausal related information in mid-aged women.This was a cross-sectional study in which 140 women aged 40 to 60 years from Guayaquil, Ecu...
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MYRF mutation leads to a single manifestation of sexual development and mimics partial androgen insensitivity syndrome: a case report and literature review Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-28 Duoduo Zhang, Qinjie Tian
To highlight the challenges in diagnosing 46, XY disorder of sex development related to MYRF mutation.We present an unusual case of a 12-year-old female child came for enlargement of clitoris and i...
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Enhanced glycolysis in the myometrium with ectopic endometrium of patients with adenomyosis: a preliminary study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-27 Shiya Huang, Xueqian Huang, Xiaohui Wen, Xuehong Liu, Hongxia Ma, Linling Xie, Yishu Wang, Shanjia Liu, Yongge Guan, Kunyin Li
The objective of this study was to investigate the glycolytic activity of adenomyosis, which is characterized by malignant biological behaviors including abnormal cell proliferation, migration, inv...
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Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-22 Wenjuan Tian, Siyu Cao, Wei Zhang, Chenlian Quan, Meiqin Zhang, Yan Huang
The aim of this study was to investigate the impact of three single nucleotide polymorphisms (SNPs) within X-Ray Repair Cross Complementary Group 2 (XRCC2) gene and additional gene- abdominal obesi...
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Efficacy and safety of visnadine in the treatment of symptoms of sexual dysfunction in heterosexual women: a systematic review of randomized clinical trials Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-25 Brenda Caira-Chuquineyra, Daniel Fernandez-Guzmán, Humberto Garayar-Peceros, Vicente A. Benites-Zapata, Faustino R. Pérez-López, Juan E. Blümel, Edward Mezones-Holguín
To synthesize the primary evidence on the efficacy and safety of visnadine on symptoms of sexual dysfunction (SD) in heterosexual women.We conducted a systematic review of randomized clinical trial...
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Association between anxiety and frailty in postmenopausal women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-18 Alicia García-Vigara, Julio Fernandez-Garrido, Peter Chedraui, Aitana Monllor-Tormos, Miguel Ángel García-Pérez, Juan José Tarín, Arturo Artero, Antonio Cano
To explore the association between anxiety and frailty in community-dwelling postmenopausal women.This was a cross-sectional study in which 390 postmenopausal women (aged 60–83 years) who were atte...
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Quantitative proteomics reveals pregnancy prognosis signature of polycystic ovary syndrome women based on machine learning Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-18 Yuanyuan Wu, Cai Liu, Jinge Huang, Fang Wang
We aimed to screen and construct a predictive model for pregnancy loss in polycystic ovary syndrome (PCOS) patients through machine learning methods.We obtained the endometrial samples from 33 PCOS...
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Bushen Huoxue Recipe inhibits endometrial epithelial-mesenchymal transition through the transforming growth factor-β/nuclear factor kappa-B pathway to improve polycystic ovary syndrome-mediated infertility Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-13 Hanxue Wu, Peijuan Wu, Ying Zhu, Junjie Li, Haiyan Chen, Hongqiu Zhu
To investigate the target and mechanism of action of Bushen Huoxue Recipe (BSHX) for the treatment of infertility in polycystic ovary syndrome (PCOS), to provide a basis for the development and cli...
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Expression of Concern: Laparoscopic ovarian drilling versus GnRH antagonist combined with cabergoline as a prophylaxis against the re-development of ovarian hyperstimulation syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-11
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Prospective, multicenter, uncontrolled study on the effectiveness and safety of a hyaluronic acid water-based vaginal lubricant in alleviating vaginal dryness and dyspareunia Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-12 Manuel Sánchez-Prieto, Carmen Pingarrón, Luciana Bergamaschi, Juan Carlos Bermúdez, José Subiris González, Ruth Sánchez Sánchez, Sílvia Poyo Torcal, Matilde Gómez, María Luisa Ruiz Pérez, Marta Castillo Martínez, M. Eugenia Peña Penedo, Rafael Sánchez-Borrego
Vaginal dryness (VD) represents a significant concern affecting women across diverse life stages, encompassing both pre- and postmenopausal women at any age. Dyspareunia, defined by genital pain th...
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Expression of Concern: Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-11
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Statement of Retraction: Evaluation of prolonged use of statins on the clinical and biochemical abnormalities and ovulation dysfunction in single young women with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-11
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Metabolic disparities between obese and non-obese patients with polycystic ovary syndrome: implications for endometrial receptivity indicators Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-06 Xiao-li Li, Yan-fei Ji, Yu Feng, Shi-wei Liu
To investigate the differences in the metabolic indicators and sex hormones between obese and non-obese patients with polycystic ovary syndrome (PCOS), and their impacts on endometrial receptivity ...
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Female obesity increases the risk of preterm birth of single frozen-thawed euploid embryos: a retrospective cohort study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-04 Xitong Liu, Juanzi Shi
Obesity has been associated with an increased risk of reproductive failure, especially preterm birth. As preimplantation genetic testing for aneuploidies (PGT-A) is increasingly used worldwide, how...
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The potential role of uric acid in women with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-04 Zhentao Gong, Lingshan Zhang, Yingli Shi
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age and is associated with a variety of multi-system complications. The prevailing treatment strategy ...
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The significance of obesity for women’s sexuality in the life span Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-04 Peter Chedraui, Rossella E. Nappi
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Contributing factors for pregnancy outcomes in women with PCOS after their first FET treatment: a retrospective cohort study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-13 Xi Chen, Ling Hong, Meilan Mo, Shan Xiao, Tailang Yin, Su Liu
We aim to explore the contributing factors of clinical pregnancy outcomes in PCOS patients undergoing their first FET treatment.A retrospective analysis was conducted on 574 PCOS patients undergoin...
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Obesity and menopause Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-11 Santiago Palacios, Peter Chedraui, Rafael Sánchez-Borrego, Pluvio Coronado, Rossella E. Nappi
Obesity is not a choice or a result of lack of willpower, but a multifactorial, chronic, progressive, and relapsing disease. During menopause, hormonal and body composition changes lead to greater ...
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Comparison of resumption of ovulation after cessation of oral contraceptives and medroxyprogesterone acetate in women with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-02 Soo Jin Han, Hoon Kim, Seung-Yup Ku, Chang Suk Suh
Both oral contraceptive pills (OCPs) and cyclic medroxyprogesterone acetate (MPA) are widely used to control menstrual abnormalities in women with polycystic ovary syndrome (PCOS). We aimed to eval...
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Dienogest does not augment the gene expression of adhesion molecules, MCP-1, and monocyte adherence in human endothelial cells Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-01 Nanami Tahara, Fumitake Ito, Mari Kawamata, Masahiro Otani, Taisuke Mori
Medroxyprogesterone acetate (MPA) may increase the risk of atherosclerosis during hormone replacement therapy (HRT); therefore, the effect of progestogens other than MPA on atherosclerotic lesions ...
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Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-01-18 Iñaki Lete, Ainara Martínez, Irene Lasaga, Eva Centurión, Amaia Vesga
In this article, we present a narrative review on the use of inositol in the treatment of polycystic ovary syndrome (PCOS). Of the different inositols that exist, only myo-inositol (MYO) and D-chir...
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Correlation between chronic low-grade inflammation and glucose and lipid metabolism indicators in polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-01-12 Yan Zhou, Xia Wang, Siqi Guo, Ruiying Li, Ye Li, Ying Yu, Ting Liu
The purpose of this study was to explore the correlation between inflammatory indicators and blood lipids and to further provide a theoretical basis for the diagnosis and treatment of clinical poly...
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Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3 Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-01-09 Caglar Cetin, Sabri Berkem Okten, Olgu Enis Tok, Pınar Ozcan, Ayse Filiz Gokmen Karasu, Fatma Basak Tanoglu, Havva Sevde Taha, Seda Ates
To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy).Forty-two Sp...
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Emerging trends and research priorities in premature ovarian insufficiency genes: a bibliometric and visualization study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-27 Xi Zhao, Wenying Shi, Xiaojuan Liu, Wei Zhang
To illustrate the results achieved by genes in premature ovarian insufficiency (POI) and collaborations in the field, and to explore key themes and future directions.Articles and reviews related to...
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Expression of high-mobility group box-1 in eutopic/ectopic endometrium and correlations with inflammation-related factors in adenomyosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-15 Xiu-Ni Liu, Zhong-Ping Cheng
To investigate the expression of HMGB1 and toll-like receptor 4 (TLR4) in adenomyosis eutopic/ectopic endometrium.Twenty patients with adenomyosis and 20 controls, all undergoing laparoscopy, were ...
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N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-06 Yuan-Xue Jing, Hong-Xing Li, Feng Yue, Yan-Mei Li, Xiao Yu, Jia-Jing He, Xue-Hong Zhang
Polycystic ovary syndrome (PCOS) was known as the common endocrine disease in women, featured as hyperandrogenism, ovulation disorders, etc. Fat mass and obesity-associated protein (FTO), a m6A dem...
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Association between leptin receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis based on 11 studies Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-07 Na-Na Wang, Min Tang, Han-Yu Zhang, Qiao-Zhen Yang, Gong-Li Yang
Published evidence indicated that the leptin receptor (LEPR) gene polymorphisms are associated with polycystic ovary syndrome (PCOS) risk. However, studies on the association between the polymorphi...
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Statement of Retraction: Minimal stimulation or clomiphene citrate as first-line therapy in women with polycystic ovary syndrome: a randomized controlled trial Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-07
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Statement of Retraction: Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-07
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Is elevated baseline SHBG associated with increased ovulation? Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-01 Hui Chang, Hang Ge, Qi Wu, Jian Li, Yanli Zhang, Mengyi Zhu, Xi Luo, Yanhua Han, Yong Wang, Chi Chiu Wang, Xiaoke Wu
Sexual hormone binding globulin (SHBG) is associated with the endocrine and reproductive systems. We aimed to investigate the role of SHBG in the reproductive process. Therefore, we conducted a sec...
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Anti-Müllerian Hormone promotes human osteoblast differentiation and calcification by modulating osteogenic gene expression Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-01 Francesca Liuzzi, Marilena Taggi, Serena De Carlini, Antonio La Marca
To investigate whether the Anti-Müllerian Hormone (AMH), an ovarian hormone belonging to the Transforming Growth Factor β superfamily, may represent a possible candidate for use as a bone anabolic ...
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Vasorin: a new molecule in human reproduction? Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-26 Antonio La Marca, Serena De Carlini, Francesca Liuzzi
Published in Gynecological Endocrinology (Vol. 39, No. 1, 2023)
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The effects of different endometrial preparation regimens on pregnancy outcomes in frozen-thawed embryo transfer cycles: a prospective randomized controlled study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-20 Jianyun Huang, Xuedan Jiao, Yang You, Yingchen Wu, Haiyan Lin, Qingxue Zhang
An increasing number of research have emerged to compare the pregnancy outcomes between the natural cycle and the hormone replacement therapy (HRT) cycle in preparing the endometrium for frozen-tha...
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Expression and significance of silent information regulator two homolog 1 in the placenta and plasma of patients with pre-eclampsia—a meta-analysis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-19 Hongling Wang, Wenwen Liang, Weihua Su, Hong Cui, Huifeng Wang
This study aimed to collect, organize, and conduct a meta-analysis of the literature on the expression of silent information regulator two homolog 1 (SIRT1) in the placental tissue and plasma of pa...
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Down-regulation of the FTO gene in follicular fluid of infertile women with ovarian endometriosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-23 Yanmei Li, Naihui Wang, Yuanxue Jing, Jiajing He, Fangfang Li, Xuehong Zhang
To evaluate FTO concentrations in follicular fluid (FF) of women with ovarian endometriosis (OE) and controls women without OE undergoing in vitro fertilization-embryo transfer (IVF-ET).FTO concent...
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Combined oral contraceptives: update recommendations of the Latin American contraceptive association Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-19 Santiago Palacios, Gabriela Ayala, Gemarilis González, Can L. Badilla-Apuy, Jeannette Marchena, Katia Martínez, Desireé Mostajo, María S. Vernaza, Alejandro Paradas, Luis Hernández, David Vásquez-Awad, Cuauhtémoc Celis-González, Nilson Roberto de Melo
Background: In recent years, new combined oral contraceptives (COCs) have become available, representing an advance in terms of individualization and compliance by users.Objective: To provide recom...
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Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-20 Xiao-xiao Wang, Teng Hua, Hong-bo Wang
Estrogen receptor-related receptor γ (ERRγ), is implicated in cancer cell proliferation and metastasis. The function of ERRγ in tumor angiogenesis, however, is to be revealed. This study was design...
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LIPUS combined with TFSC alleviates premature ovarian failure by promoting autophagy and inhibiting apoptosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-19 Weimei Zhou, Aixue Chen, Yongju Ye, Yuefang Ren, Jiali Lu, Feilan Xuan, Ruiying Jin
Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a major cause of infertility in female worldwide. Excessive apoptosis and impaired autophagy in ovarian granulosa ce...
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Effect of Bushen Huoxue recipe on serum metabolomics in polycystic ovary syndrome rats Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-17 Junjie Li, Hongqiu Zhu, Ying Zhu, Peijuan Wu, Hanxue Wu, Haiyan Chen
To investigate the effect of Bushen Huoxue Recipe (BSHXR) on serum metabolomics in polycystic ovary syndrome rat (PCOSR).In our study, twenty-four 6-week-old Sprague-Dawley (SD) female rats were ra...
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A novel missense variant in LAMC1 identified in a POI family by whole exome sequencing Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-15 Huanfang Xu, Chunyan Wang, Han Wei, Tengyan Li, Yigong Fang, Binbin Wang
This study aimed to identify novel pathogenic genes and variants in a Chinese family with premature ovarian insufficiency (POI).A Chinese POI family was enrolled in this study. Whole exome sequenci...
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Estrogen promotes the proliferation and migration of endometrial cancer cells by upregulating the expression of lncRNA HOTAIR Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-17 Huixiao Wang, Xulan Ma, Ziwen Jiang, Di Xia, Feng Sui, Fengxian Fu, Yinmei Dai
Estrogen (E2) is the main contributor to the progression of endometrial cancer (EC). The long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is emerging as a new regulator in several cancer ty...
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The natural cycle protocol of endometrial preparation for frozen embryo transfer decreases the miscarriage rate in women with recurrent pregnancy loss Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-15 Xin Mu, Xitong Liu, Hanying Zhou, Juanzi Shi
To investigate whether different endometrial preparation methods lead to different results.Retrospective cohort study.Women with recurrent pregnancy loss undergoing frozen embryo transfer (FET).Nat...
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Cocktail treatment by GnRH-antagonist, letrozole, and mifepristone for the prevention of ovarian hyperstimulation syndrome: a prospective randomized trial Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-16 Qianrong Qi, Yi Xia, Jin Luo, Yaqin Wang, Qingzhen Xie
This study is aimed to determine the efficacy of a cocktail style treatment by combining GnRH-antagonist, letrozole, and mifepristone on the prevention of ovarian hyperstimulation syndrome (OHSS) i...
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Vulvovaginal atrophy in the CRETA study: the healthcare professionals’ perception Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-09 María J. Cancelo, Rafael Sánchez Borrego, Santiago Palacios, Laura Baquedano, Tanit Corbacho Garza, Noelia Fernández Aller, Carmen García Ferreiro, Juan José Quijano Martín, A. Javier González Calvo
The objective is to assess the perception of gynecologists regarding patients’ adherence to vulvovaginal atrophy (VVA) treatments, to evaluate the gynecologists’ opinions on what their patients thi...
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TPOAb positivity can impact ovarian reserve, embryo quality, and IVF/ICSI outcomes in euthyroid infertile women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-05 Shi-Xi Wei, Ling Wang, Yu-Bing Liu, Qiu-Lin Fan, Yu Fan, Kun Qiao
The aim of this study was to investigate the effects of positive anti-thyroid peroxidase (TPO) antibodies on fertility, embryo quality, and pregnancy outcomes in women with normal thyroid function....
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The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-14 Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan
Abstract Objective GuizhiFulingWan (GFW) has been reported to be effective against polycystic ovary syndrome (PCOS) by possessing oxidative stress and inflammation which related to PI3K/AKT/NF-κB, Nrf2/HO-1 pathway. This study aims to probe the effects and mechanisms of GFW combined with rosiglitazone on PCOS via PI3K/AKT/NF-κB and Nrf2/HO-1 pathways. Methods A rat PCOS model established by dehydroepiandrosterone
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Congenital adrenal hyperplasia disorder due to 17 α-hydroxylase deficiency: a case report Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-08 Yunling Tian, Lijie Hou, Shulan Xiang, Xuguang Tian, Jinhui Xu
Abstract Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder with a related enzyme deficiency involved in the adrenal corticosteroid synthesis pathway due to genetic mutations. 17α-hydroxylase deficiency(17α-OHD) is a rare form of CAH. Herein, we reported clinical data on diagnosis and treatment regimens for a 17α-hydroxylase-deficient patient. A 24-year-old female patient was admitted
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Association between endometriosis and metabolic syndrome: a cross-sectional study based on the National Health and Nutrition Examination Survey data Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-06 Baijia Li, Yuxue Zhang, Liuhang Zhang, Lingyan Zhang
Abstract Background Endometriosis has been reported to be associated with metabolism-related diseases, such as hypercholesterolemia and diabetes, while no studies have reported the association between endometriosis and metabolic syndrome. Objective This study aims to explore the association between endometriosis and metabolic syndrome. Also, the association between endometriosis and single metabolic
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Prevalence of metabolic syndrome and its components in Chinese women with premature ovarian insufficiency Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-06 Jing Jin, Xiangyan Ruan, Lin Hua, Alfred O. Mueck
Abstract Objectives To assess the prevalence of metabolic syndrome (MetS) and its components in Chinese women with premature ovarian insufficiency (POI) and to explore the metabolic profile of Chinese women with POI. Methods 118 POI women aged 20-38 years and 151 age-and-BMI-matched control women were recruited. Measurements included body height, weight, waist circumference (WC), hip circumference
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Overcoming barriers to oral contraception in Italy an expert opinion to empower women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-04 Rossella E. Nappi, Manuela Farris, Achille Gallina Toschi, Raffaella Michieli, Francesca Moccia, Nicoletta Orthmann, Emilio Arisi
Abstract Oral contraceptives are among the most commonly used contraceptive methods. However, Italian women underused reliable hormonal contraceptives as compared with other European women. There is a need to streamline access to oral contraception, with expected benefits on emotional well-being of women and potential savings for health system in Italy. Indeed, women can only access to oral contraceptives
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Mutation of aspartic acid 262 on estrogen receptor abrogates estradiol signaling pathway Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-30 Xingyan Xu, Haowei Yu, Shuihao Zhu, Ping Li, Xiaosa Li, Yongqi Gao, Yixiao Xiang, Guojun Zhao, Tommaso Simoncini, Huiping Lin
Abstract Objective ERα (estrogen receptor alpha) exerts nuclear genomic actions and membrane-initiated non-genomic effects. The mutation of aspartic acid into alanine in vitro revealed the critical role of aspartic acid 258 (corresponding to mouse amino acid site 262) of ERα for non-nuclear function. Our previous in vitro study revealed that this mutation blocked estrogen’s non-genomic effects on vascular
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Relugolix combination therapy in European women with symptomatic uterine fibroids: a subgroup analysis from the randomized phase 3 LIBERTY pivotal trials Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-27 Roberta Venturella, Tomasz Rechberger, János Zatik, Rachel B. Wagman, Emily Zhu, Viatcheslav G. Rakov, Felice Petraglia
Abstract Objective In the 24-week, phase 3 LIBERTY 1 (L1) and LIBERTY 2 (L2) trials, relugolix combination therapy (relugolix-CT (relugolix 40 mg, estradiol 1 mg, norethisterone acetate 0.5 mg)) reduced uterine fibroid (UF)-associated symptoms. This post hoc analysis assessed safety and efficacy of relugolix-CT in European women from L1/L2. Methods Premenopausal women (aged 18–50 years) with UF-associated
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SIRT6 reduces the symptoms of premature ovarian failure and alleviates oxidative stress and apoptosis in granulosa cells by degrading p66SHC via H3K9AC Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-27 Chuan Shen, Yongmei Jiang, Jia Lin, Yibei He, Yue Liu, Dingzhi Fang
Abstract Context Substantial evidence suggests that ovarian oxidative stress can result in severe ovarian dysfunction. Objective The purpose of this article is to investigate the potential of SIRT6 in alleviating premature ovarian failure (POF) by inhibiting oxidative stress. Methods To mimic POF, mice were administered daily subcutaneous injections of d-galactose. The levels of E2, FSH, LH, AMH, and