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Bushen Huoxue Recipe inhibits endometrial epithelial-mesenchymal transition through the transforming growth factor-β/nuclear factor kappa-B pathway to improve polycystic ovary syndrome-mediated infertility Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-13 Hanxue Wu, Peijuan Wu, Ying Zhu, Junjie Li, Haiyan Chen, Hongqiu Zhu
To investigate the target and mechanism of action of Bushen Huoxue Recipe (BSHX) for the treatment of infertility in polycystic ovary syndrome (PCOS), to provide a basis for the development and cli...
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Expression of Concern: Laparoscopic ovarian drilling versus GnRH antagonist combined with cabergoline as a prophylaxis against the re-development of ovarian hyperstimulation syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-11
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Prospective, multicenter, uncontrolled study on the effectiveness and safety of a hyaluronic acid water-based vaginal lubricant in alleviating vaginal dryness and dyspareunia Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-12 Manuel Sánchez-Prieto, Carmen Pingarrón, Luciana Bergamaschi, Juan Carlos Bermúdez, José Subiris González, Ruth Sánchez Sánchez, Sílvia Poyo Torcal, Matilde Gómez, María Luisa Ruiz Pérez, Marta Castillo Martínez, M. Eugenia Peña Penedo, Rafael Sánchez-Borrego
Vaginal dryness (VD) represents a significant concern affecting women across diverse life stages, encompassing both pre- and postmenopausal women at any age. Dyspareunia, defined by genital pain th...
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Expression of Concern: Evaluation of the correlation between insulin like factor 3, polycystic ovary syndrome, and ovarian maldescent Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-11
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Statement of Retraction: Evaluation of prolonged use of statins on the clinical and biochemical abnormalities and ovulation dysfunction in single young women with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-11
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Metabolic disparities between obese and non-obese patients with polycystic ovary syndrome: implications for endometrial receptivity indicators Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-06 Xiao-li Li, Yan-fei Ji, Yu Feng, Shi-wei Liu
To investigate the differences in the metabolic indicators and sex hormones between obese and non-obese patients with polycystic ovary syndrome (PCOS), and their impacts on endometrial receptivity ...
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Female obesity increases the risk of preterm birth of single frozen-thawed euploid embryos: a retrospective cohort study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-04 Xitong Liu, Juanzi Shi
Obesity has been associated with an increased risk of reproductive failure, especially preterm birth. As preimplantation genetic testing for aneuploidies (PGT-A) is increasingly used worldwide, how...
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The potential role of uric acid in women with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-04 Zhentao Gong, Lingshan Zhang, Yingli Shi
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age and is associated with a variety of multi-system complications. The prevailing treatment strategy ...
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The significance of obesity for women’s sexuality in the life span Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-03-04 Peter Chedraui, Rossella E. Nappi
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Contributing factors for pregnancy outcomes in women with PCOS after their first FET treatment: a retrospective cohort study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-13 Xi Chen, Ling Hong, Meilan Mo, Shan Xiao, Tailang Yin, Su Liu
We aim to explore the contributing factors of clinical pregnancy outcomes in PCOS patients undergoing their first FET treatment.A retrospective analysis was conducted on 574 PCOS patients undergoin...
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Obesity and menopause Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-11 Santiago Palacios, Peter Chedraui, Rafael Sánchez-Borrego, Pluvio Coronado, Rossella E. Nappi
Obesity is not a choice or a result of lack of willpower, but a multifactorial, chronic, progressive, and relapsing disease. During menopause, hormonal and body composition changes lead to greater ...
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Comparison of resumption of ovulation after cessation of oral contraceptives and medroxyprogesterone acetate in women with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-02 Soo Jin Han, Hoon Kim, Seung-Yup Ku, Chang Suk Suh
Both oral contraceptive pills (OCPs) and cyclic medroxyprogesterone acetate (MPA) are widely used to control menstrual abnormalities in women with polycystic ovary syndrome (PCOS). We aimed to eval...
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Dienogest does not augment the gene expression of adhesion molecules, MCP-1, and monocyte adherence in human endothelial cells Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-02-01 Nanami Tahara, Fumitake Ito, Mari Kawamata, Masahiro Otani, Taisuke Mori
Medroxyprogesterone acetate (MPA) may increase the risk of atherosclerosis during hormone replacement therapy (HRT); therefore, the effect of progestogens other than MPA on atherosclerotic lesions ...
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Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-01-18 Iñaki Lete, Ainara Martínez, Irene Lasaga, Eva Centurión, Amaia Vesga
In this article, we present a narrative review on the use of inositol in the treatment of polycystic ovary syndrome (PCOS). Of the different inositols that exist, only myo-inositol (MYO) and D-chir...
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Correlation between chronic low-grade inflammation and glucose and lipid metabolism indicators in polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-01-12 Yan Zhou, Xia Wang, Siqi Guo, Ruiying Li, Ye Li, Ying Yu, Ting Liu
The purpose of this study was to explore the correlation between inflammatory indicators and blood lipids and to further provide a theoretical basis for the diagnosis and treatment of clinical poly...
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Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3 Gynecol. Endocrinol. (IF 2.0) Pub Date : 2024-01-09 Caglar Cetin, Sabri Berkem Okten, Olgu Enis Tok, Pınar Ozcan, Ayse Filiz Gokmen Karasu, Fatma Basak Tanoglu, Havva Sevde Taha, Seda Ates
To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy).Forty-two Sp...
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Emerging trends and research priorities in premature ovarian insufficiency genes: a bibliometric and visualization study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-27 Xi Zhao, Wenying Shi, Xiaojuan Liu, Wei Zhang
To illustrate the results achieved by genes in premature ovarian insufficiency (POI) and collaborations in the field, and to explore key themes and future directions.Articles and reviews related to...
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Expression of high-mobility group box-1 in eutopic/ectopic endometrium and correlations with inflammation-related factors in adenomyosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-15 Xiu-Ni Liu, Zhong-Ping Cheng
To investigate the expression of HMGB1 and toll-like receptor 4 (TLR4) in adenomyosis eutopic/ectopic endometrium.Twenty patients with adenomyosis and 20 controls, all undergoing laparoscopy, were ...
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N6-methyladenosine demethylase FTO related to hyperandrogenism in PCOS via AKT pathway Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-06 Yuan-Xue Jing, Hong-Xing Li, Feng Yue, Yan-Mei Li, Xiao Yu, Jia-Jing He, Xue-Hong Zhang
Polycystic ovary syndrome (PCOS) was known as the common endocrine disease in women, featured as hyperandrogenism, ovulation disorders, etc. Fat mass and obesity-associated protein (FTO), a m6A dem...
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Association between leptin receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis based on 11 studies Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-07 Na-Na Wang, Min Tang, Han-Yu Zhang, Qiao-Zhen Yang, Gong-Li Yang
Published evidence indicated that the leptin receptor (LEPR) gene polymorphisms are associated with polycystic ovary syndrome (PCOS) risk. However, studies on the association between the polymorphi...
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Statement of Retraction: Minimal stimulation or clomiphene citrate as first-line therapy in women with polycystic ovary syndrome: a randomized controlled trial Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-07
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Statement of Retraction: Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-07
Published in Gynecological Endocrinology (Vol. 40, No. 1, 2024)
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Is elevated baseline SHBG associated with increased ovulation? Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-01 Hui Chang, Hang Ge, Qi Wu, Jian Li, Yanli Zhang, Mengyi Zhu, Xi Luo, Yanhua Han, Yong Wang, Chi Chiu Wang, Xiaoke Wu
Sexual hormone binding globulin (SHBG) is associated with the endocrine and reproductive systems. We aimed to investigate the role of SHBG in the reproductive process. Therefore, we conducted a sec...
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Anti-Müllerian Hormone promotes human osteoblast differentiation and calcification by modulating osteogenic gene expression Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-11-01 Francesca Liuzzi, Marilena Taggi, Serena De Carlini, Antonio La Marca
To investigate whether the Anti-Müllerian Hormone (AMH), an ovarian hormone belonging to the Transforming Growth Factor β superfamily, may represent a possible candidate for use as a bone anabolic ...
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Vasorin: a new molecule in human reproduction? Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-26 Antonio La Marca, Serena De Carlini, Francesca Liuzzi
Published in Gynecological Endocrinology (Vol. 39, No. 1, 2023)
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The effects of different endometrial preparation regimens on pregnancy outcomes in frozen-thawed embryo transfer cycles: a prospective randomized controlled study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-20 Jianyun Huang, Xuedan Jiao, Yang You, Yingchen Wu, Haiyan Lin, Qingxue Zhang
An increasing number of research have emerged to compare the pregnancy outcomes between the natural cycle and the hormone replacement therapy (HRT) cycle in preparing the endometrium for frozen-tha...
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Expression and significance of silent information regulator two homolog 1 in the placenta and plasma of patients with pre-eclampsia—a meta-analysis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-19 Hongling Wang, Wenwen Liang, Weihua Su, Hong Cui, Huifeng Wang
This study aimed to collect, organize, and conduct a meta-analysis of the literature on the expression of silent information regulator two homolog 1 (SIRT1) in the placental tissue and plasma of pa...
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Down-regulation of the FTO gene in follicular fluid of infertile women with ovarian endometriosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-23 Yanmei Li, Naihui Wang, Yuanxue Jing, Jiajing He, Fangfang Li, Xuehong Zhang
To evaluate FTO concentrations in follicular fluid (FF) of women with ovarian endometriosis (OE) and controls women without OE undergoing in vitro fertilization-embryo transfer (IVF-ET).FTO concent...
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Combined oral contraceptives: update recommendations of the Latin American contraceptive association Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-19 Santiago Palacios, Gabriela Ayala, Gemarilis González, Can L. Badilla-Apuy, Jeannette Marchena, Katia Martínez, Desireé Mostajo, María S. Vernaza, Alejandro Paradas, Luis Hernández, David Vásquez-Awad, Cuauhtémoc Celis-González, Nilson Roberto de Melo
Background: In recent years, new combined oral contraceptives (COCs) have become available, representing an advance in terms of individualization and compliance by users.Objective: To provide recom...
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Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-20 Xiao-xiao Wang, Teng Hua, Hong-bo Wang
Estrogen receptor-related receptor γ (ERRγ), is implicated in cancer cell proliferation and metastasis. The function of ERRγ in tumor angiogenesis, however, is to be revealed. This study was design...
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LIPUS combined with TFSC alleviates premature ovarian failure by promoting autophagy and inhibiting apoptosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-19 Weimei Zhou, Aixue Chen, Yongju Ye, Yuefang Ren, Jiali Lu, Feilan Xuan, Ruiying Jin
Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a major cause of infertility in female worldwide. Excessive apoptosis and impaired autophagy in ovarian granulosa ce...
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Effect of Bushen Huoxue recipe on serum metabolomics in polycystic ovary syndrome rats Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-17 Junjie Li, Hongqiu Zhu, Ying Zhu, Peijuan Wu, Hanxue Wu, Haiyan Chen
To investigate the effect of Bushen Huoxue Recipe (BSHXR) on serum metabolomics in polycystic ovary syndrome rat (PCOSR).In our study, twenty-four 6-week-old Sprague-Dawley (SD) female rats were ra...
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A novel missense variant in LAMC1 identified in a POI family by whole exome sequencing Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-15 Huanfang Xu, Chunyan Wang, Han Wei, Tengyan Li, Yigong Fang, Binbin Wang
This study aimed to identify novel pathogenic genes and variants in a Chinese family with premature ovarian insufficiency (POI).A Chinese POI family was enrolled in this study. Whole exome sequenci...
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Estrogen promotes the proliferation and migration of endometrial cancer cells by upregulating the expression of lncRNA HOTAIR Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-17 Huixiao Wang, Xulan Ma, Ziwen Jiang, Di Xia, Feng Sui, Fengxian Fu, Yinmei Dai
Estrogen (E2) is the main contributor to the progression of endometrial cancer (EC). The long noncoding RNA HOX antisense intergenic RNA (HOTAIR) is emerging as a new regulator in several cancer ty...
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The natural cycle protocol of endometrial preparation for frozen embryo transfer decreases the miscarriage rate in women with recurrent pregnancy loss Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-15 Xin Mu, Xitong Liu, Hanying Zhou, Juanzi Shi
To investigate whether different endometrial preparation methods lead to different results.Retrospective cohort study.Women with recurrent pregnancy loss undergoing frozen embryo transfer (FET).Nat...
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Cocktail treatment by GnRH-antagonist, letrozole, and mifepristone for the prevention of ovarian hyperstimulation syndrome: a prospective randomized trial Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-16 Qianrong Qi, Yi Xia, Jin Luo, Yaqin Wang, Qingzhen Xie
This study is aimed to determine the efficacy of a cocktail style treatment by combining GnRH-antagonist, letrozole, and mifepristone on the prevention of ovarian hyperstimulation syndrome (OHSS) i...
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Vulvovaginal atrophy in the CRETA study: the healthcare professionals’ perception Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-09 María J. Cancelo, Rafael Sánchez Borrego, Santiago Palacios, Laura Baquedano, Tanit Corbacho Garza, Noelia Fernández Aller, Carmen García Ferreiro, Juan José Quijano Martín, A. Javier González Calvo
The objective is to assess the perception of gynecologists regarding patients’ adherence to vulvovaginal atrophy (VVA) treatments, to evaluate the gynecologists’ opinions on what their patients thi...
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TPOAb positivity can impact ovarian reserve, embryo quality, and IVF/ICSI outcomes in euthyroid infertile women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-10-05 Shi-Xi Wei, Ling Wang, Yu-Bing Liu, Qiu-Lin Fan, Yu Fan, Kun Qiao
The aim of this study was to investigate the effects of positive anti-thyroid peroxidase (TPO) antibodies on fertility, embryo quality, and pregnancy outcomes in women with normal thyroid function....
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The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-14 Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan
Abstract Objective GuizhiFulingWan (GFW) has been reported to be effective against polycystic ovary syndrome (PCOS) by possessing oxidative stress and inflammation which related to PI3K/AKT/NF-κB, Nrf2/HO-1 pathway. This study aims to probe the effects and mechanisms of GFW combined with rosiglitazone on PCOS via PI3K/AKT/NF-κB and Nrf2/HO-1 pathways. Methods A rat PCOS model established by dehydroepiandrosterone
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Congenital adrenal hyperplasia disorder due to 17 α-hydroxylase deficiency: a case report Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-08 Yunling Tian, Lijie Hou, Shulan Xiang, Xuguang Tian, Jinhui Xu
Abstract Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder with a related enzyme deficiency involved in the adrenal corticosteroid synthesis pathway due to genetic mutations. 17α-hydroxylase deficiency(17α-OHD) is a rare form of CAH. Herein, we reported clinical data on diagnosis and treatment regimens for a 17α-hydroxylase-deficient patient. A 24-year-old female patient was admitted
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Association between endometriosis and metabolic syndrome: a cross-sectional study based on the National Health and Nutrition Examination Survey data Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-06 Baijia Li, Yuxue Zhang, Liuhang Zhang, Lingyan Zhang
Abstract Background Endometriosis has been reported to be associated with metabolism-related diseases, such as hypercholesterolemia and diabetes, while no studies have reported the association between endometriosis and metabolic syndrome. Objective This study aims to explore the association between endometriosis and metabolic syndrome. Also, the association between endometriosis and single metabolic
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Prevalence of metabolic syndrome and its components in Chinese women with premature ovarian insufficiency Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-06 Jing Jin, Xiangyan Ruan, Lin Hua, Alfred O. Mueck
Abstract Objectives To assess the prevalence of metabolic syndrome (MetS) and its components in Chinese women with premature ovarian insufficiency (POI) and to explore the metabolic profile of Chinese women with POI. Methods 118 POI women aged 20-38 years and 151 age-and-BMI-matched control women were recruited. Measurements included body height, weight, waist circumference (WC), hip circumference
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Overcoming barriers to oral contraception in Italy an expert opinion to empower women Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-09-04 Rossella E. Nappi, Manuela Farris, Achille Gallina Toschi, Raffaella Michieli, Francesca Moccia, Nicoletta Orthmann, Emilio Arisi
Abstract Oral contraceptives are among the most commonly used contraceptive methods. However, Italian women underused reliable hormonal contraceptives as compared with other European women. There is a need to streamline access to oral contraception, with expected benefits on emotional well-being of women and potential savings for health system in Italy. Indeed, women can only access to oral contraceptives
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Mutation of aspartic acid 262 on estrogen receptor abrogates estradiol signaling pathway Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-30 Xingyan Xu, Haowei Yu, Shuihao Zhu, Ping Li, Xiaosa Li, Yongqi Gao, Yixiao Xiang, Guojun Zhao, Tommaso Simoncini, Huiping Lin
Abstract Objective ERα (estrogen receptor alpha) exerts nuclear genomic actions and membrane-initiated non-genomic effects. The mutation of aspartic acid into alanine in vitro revealed the critical role of aspartic acid 258 (corresponding to mouse amino acid site 262) of ERα for non-nuclear function. Our previous in vitro study revealed that this mutation blocked estrogen’s non-genomic effects on vascular
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Relugolix combination therapy in European women with symptomatic uterine fibroids: a subgroup analysis from the randomized phase 3 LIBERTY pivotal trials Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-27 Roberta Venturella, Tomasz Rechberger, János Zatik, Rachel B. Wagman, Emily Zhu, Viatcheslav G. Rakov, Felice Petraglia
Abstract Objective In the 24-week, phase 3 LIBERTY 1 (L1) and LIBERTY 2 (L2) trials, relugolix combination therapy (relugolix-CT (relugolix 40 mg, estradiol 1 mg, norethisterone acetate 0.5 mg)) reduced uterine fibroid (UF)-associated symptoms. This post hoc analysis assessed safety and efficacy of relugolix-CT in European women from L1/L2. Methods Premenopausal women (aged 18–50 years) with UF-associated
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SIRT6 reduces the symptoms of premature ovarian failure and alleviates oxidative stress and apoptosis in granulosa cells by degrading p66SHC via H3K9AC Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-27 Chuan Shen, Yongmei Jiang, Jia Lin, Yibei He, Yue Liu, Dingzhi Fang
Abstract Context Substantial evidence suggests that ovarian oxidative stress can result in severe ovarian dysfunction. Objective The purpose of this article is to investigate the potential of SIRT6 in alleviating premature ovarian failure (POF) by inhibiting oxidative stress. Methods To mimic POF, mice were administered daily subcutaneous injections of d-galactose. The levels of E2, FSH, LH, AMH, and
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A prospective study on the endometrium properties and the pregnancy rate of infertile women with thin endometrium receiving Fructus ligustri lucidi used in traditional Chinese medicine Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-25 Xiangyan Ruan, Zhongting Xu, Xin Xu, Yu Yang, Jiaojiao Cheng, Suiyu Luo, Min Min, Meng Li, Luping Zhang, Rui Ju, Fengyu Jin, Alfred Otto Mueck
Abstract Objective To evaluate whether Zi Gui Nv Zhen capsules (ZGNZC) can increase the fertility rate of Chinese women with infertility due to thin endometrium. Methods Prospective, randomized, open-labeled 3-monthly study; 104 patients (aged 20–40 years) receiving either ZGNZC (experimental group, n = 55) or not (control group, n = 49). Main outcomes: thickness/type of the endometrium during ovulation
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Comparisons of different treatment outcomes in IVF/ET patients with hydrosalpinx: a retrospective study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-25 Beibei Bi, Xiao Han, Wei Dai, Lanlan Fang, Hao Shi, Linli Hu
Abstract Aims To explore suggestions for clinicians on the most effective treatment for hydrosalpinx undergoing IVF-ET. Materials and Methods We reviewed 936 women with hydrosalpinx and 6715 tubal infertile women without hydrosalpinx who underwent IVF/ICSI between January 2014 and August 2019 in our center. Hydrosalpinx patients received different treatments including laparoscopic surgery (only salpingectomy
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Oxidative stress markers cannot be used as endometriosis biomarkers in infertile patients Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-22 Vid Janša, Joško Osredkar, Ivan Verdenik, Tea Lanišnik Rižner, Helena Ban Frangež
Abstract Objectives Endometriosis is a common benign gynaecological disease that significantly compromises the quality of life of patients. To date, invasive surgery is the method of choice to visually and histologically confirm endometriosis. Thus, there is a major interest to develop noninvasive diagnostic tools. Oxidative stress is one of the proposed mechanisms of pathogenesis and may be involved
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Prevalence of diminished ovarian reserve in Chinese women with follicular cysts and menstrual disorders Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-22 Jing Jin, Xiangyan Ruan, Lin Hua, Alfred O. Mueck
Abstract Objectives To assess the prevalence of diminished ovarian reserve (DOR) in Chinese women with follicular cysts and menstrual disorders and relationship to hormonal markers. Methods 117 women with follicular cysts and menstrual disorders, aged 24 ∼ 53 (39.19 ± 6.61) years; measurements of height, weight, follicle-stimulating hormone (FSH), luteinizing hormone (LH), E2, progesterone (Po), prolactin
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Differences in neonatal adverse outcomes among women with gestational diabetes mellitus managed by diet or medication: a propensity score matched analysis of a population-based sample Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-23 George Mnatzaganian, Marietta Taylor, Fan He, Nicola Yuen, H. David McIntyre, Mark Woodward, Liangkun Ma, Rachel R. Huxley
Abstract Objective Neonatal outcomes in women with and without medically managed gestational diabetes mellitus (GDM) were compared after accounting for differences in maternal baseline characteristics using a propensity score (PS) analysis. Methods Women without preexisting diabetes, delivering singletons during 2010-2017 in a large hospital, were eligible for inclusion. Using nearest-neighbour PS
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Hormonal and natural contraceptives: a review on efficacy and risks of different methods for an informed choice Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-20 Andrea R. Genazzani, Tiziana Fidecicchi, Domenico Arduini, Andrea Giannini, Tommaso Simoncini
Abstract The debate about contraception has become increasingly important as more and more people seek safe and effective contraception. More than 1 billion women of reproductive age worldwide need a method of family planning, and wellbeing, socio-economic status, culture, religion and more influence the reasons why a woman may ask for contraception. Different contraceptive methods exist, ranging from
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Timing of hormone therapy and its association with cardiovascular risk and metabolic parameters in 4-vinylcyclohexene diepoxide-induced primary ovarian insufficiency mouse model Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-21 Hyun Joo Lee, Min Jung Park, Jeong-Doo Heo, Bo Sun Joo, Jong Kil Joo
Abstract Objective To evaluate the effects of various initiation time points and durations of hormone therapy (HT) on cardiovascular and metabolic parameters of premenarche, primary ovarian insufficiency (POI) mouse model, induced by 4-vinylcyclohexene diepoxide. Methods A total of 50 mice at 4 weeks of age were developed into POI mouse model, further randomly categorized into 5 groups: control group
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Using advanced analytics to help identify women who are more likely to have a severe subjective experience of vulvovaginal atrophy: a modeling study Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-15 Rossella E. Nappi, Nicholas Panay, Santiago Palacios, Vivek Banerji, Genevieve Hall, Martire Particco, Dan Atkins
Abstract Objective To develop a model to identify women likely to be severely impacted by vulvovaginal atrophy (VVA), based on their experience of symptoms and non-clinical factors. Methods Multivariate statistics and machine-learning algorithms were used to develop models using data from a cross-sectional, observational, multinational European survey. A set of independent variables were chosen to
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The role of anti-Mullerian hormone and other correlates in patients with polycystic ovary syndrome Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-13 Moaz O. Moursi, Haya Salem, Ayman R. Ibrahim, Sandy Marzouk, Sara Al-Meraghi, Maha Al-Ajmi, Alreem Al-Naimi, Lolwa Alansari
ABSTRACT Background Anti-Müllerian hormone (AMH) has recently emerged as a promising biomarker for the detection of polycystic ovarian morphology. In polycystic ovary syndrome (PCOS), an elevated level of AMH has been suggested to add value to the Rotterdam criteria in cases of diagnostic uncertainty. In this study, we evaluated the correlation between AMH and PCOS, and the potential role of AMH in
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Autophagy-dependent ferroptosis is involved in the development of endometriosis Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-08 Hui Li, Huadi Yang, Shenyi Lu, Xinyan Wang, Xinhe Shi, Peiyu Mao
Abstract Objective Endometriosis (EMS) is an estrogen-dependent condition with unclear pathogenesis. Recent findings suggest implicate autophagy and ferroptosis in EMS development. Methods We assessed autophagy and ferroptosis proteins in EMS patients using immunohistochemistry and western blot and established an EMS rat model through allograft endometrial transplantation, confirmed via hematoxylin
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Trimester-specific reference intervals of serum homocysteine levels for pregnant women: a longitudinal study in China Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-08 Hai Liu, Qing Li, Ting Liu, Yuanting Tang, Fan Yu
Abstract Objective To investigate the physiological changes of serum homocysteine (Hcy) levels and to establish trimester-specific reference intervals of serum Hcy levels for Chinese pregnant women. Method According to the guideline of the Clinical and Laboratory Standards Institute (CLSI) C28-A3 document, 476 healthy women were recruited in West China Second University Hospital, Sichuan University
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One abnormal value or vomiting after oral glucose tolerance test in pregnancy: incidence and impact on maternal-fetal outcomes Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-07 Humberto Navarro-Martinez, Juana-Antonia Flores-Le Roux, Gemma Llauradó, Lucia Gortazar, Antonio Payà, Laura Mañé, Juan Pedro-Botet, David Benaiges
Abstract Objective To analyze pregnancy outcomes of women with one abnormal value (OAV) during oral glucose tolerance test (OGTT) or OGTT-intolerance, compared with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) pregnant women, according to whether they received any health intervention or not. Methods An observational retrospective study was designed including pregnant women
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CangFu Daotan decoction improves polycystic ovarian syndrome by downregulating FOXK1 Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-06 Chenye Wang, Jia Yu, Caifei Ding, Chunyue Chen
Abstract Objective: Polycystic ovarian syndrome (PCOS) is a prevalent gynecologic disorder, often associated with abnormal follicular development. Cangfu Daotan decoction (CFD) is a traditional Chinese medicine formula that is effective in alleviating PCOS clinically, but the specific mechanism remains unclear. Forkhead box K1 (FOXK1) is associated with cellular function. This study aimed to explore
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Rapid reduction of adenomyosis coexisting with leiomyoma volume during treatment with Relugolix Gynecol. Endocrinol. (IF 2.0) Pub Date : 2023-08-03 Keitaro Yamanaka, Keiichi Washio, Akiko Uchida, Yuki Sasagawa, Masashi Nishimoto, Yui Yamasaki, Satoshi Nagamata, Yoshito Terai
Abstract Objective This study elucidated the efficacy of Relugolix (REL) on the reduction of uterine volume and clinical symptoms for the treatment of adenomyosis. Methods We conducted a retrospective cohort study of patients who received REL (40 mg for about 20 weeks) and who underwent a hysterectomy for adenomyosis or fibroids. We divided patients into two groups: adenomyosis coexisting with fibroids