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Iridoid glycoside Cornuside alleviates the symptom of gestational diabetes mellitus by suppressing inflammation and regulating beta cell function. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-11-18 Xiaorong Cui,Yani Yu,Jia Yu,Kun Xu,Xin Sun
OBJECTIVE Gestational diabetes mellitus (GDM) is a frequently occurring complication during pregnancy and has adverse effects on both mother and off-spring. β-cell dysfunction and inflammation play important roles in GDM pathogenesis. Cornuside is an iridoid glycoside that exhibits anti-inflammation activities. In the present study, we explored the effects of Cornuside on β-cell and GDM. Design section:
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Evaluation of the characteristics of ovarian endometrioma in patients with endometriosis: efficacy of a low-dose estrogen/progestogen combination. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-11-11 Hiroaki Komatsu,Hiroshi Sunada,Yusuke Endo,Hisashi Noma,Fuminori Taniguchi,Tasuku Harada
OBJECTIVES Approximately 17-44% of women diagnosed with endometriosis have ovarian endometriomas (cysts). Although ovarian endometriomas may adversely affect quality of life and work performance, no reports have been published on the relationship between patient characteristics, cyst size, and pain associated with ovarian endometriomas. The objective of this study was to assess the association between
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Effects of low LH serum levels on oocyte retrieval, fertilization rate and embryo quality during controlled ovarian stimulation: results from a prospective cohort analysis. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-10-30 Jessica Dragotto,Giovanni Buzzaccarini,Andrea Etrusco,Antonio Simone Laganà,Renato Venezia,Sanja Terzic,Miriam Dellino,Chrysoula Margioula-Siarkou,Vittorio Unfer,Bianca Bianco,Paolo Casadio,Giovanni Bracchitta
OBJECTIVES Luteinizing hormone plays a key role in normal follicular development and oocyte maturation in controlled ovarian stimulation. Luteinizing hormone stimulates the proliferation and differentiation of theca cells for the secretion of androgens, synergistically increasing estrogen production. This study aimed to investigate the effects of low luteinizing hormone concentrations on oocyte retrieval
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Efficacy of hysteroscopy in improving fertility outcomes in women undergoing assisted reproductive technique: a systematic review and meta-analysis of randomized controlled trials. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-10-27 Salvatore Giovanni Vitale,Stefano Angioni,John Preston Parry,Attilio Di Spiezio Sardo,Sergio Haimovich,Jose Carugno,Luis Alonso Pacheco,Tirso Perez-Medina,Nash Moawad,Pasquale De Franciscis,Gaetano Riemma
INTRODUCTION Usefulness of hysteroscopy before assisted reproductive technique (ART) was considered debatable. However, over the last decade, several new trials were added to available literature. We aimed to assess the impact of diagnostic and operative hysteroscopy on reproductive outcomes of infertile women with and without intrauterine abnormalities. MATERIALS AND METHODS MEDLINE, Scopus, Scielo
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The effect of month-long daily fasting on semen parameters: A retrospective cohort study. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-10-26 Offra J Engel,Neta Doctory,Bei Sun,Netanella Miller,Matan Levi,Hanoch Schreiber,Nivin Samara,Amir Wiser,Einat Haikin Herzberger
OBJECTIVE To determine whether Ramadan month-long daily fasting affects semen analysis parameters. METHODS this retrospective cohort study was conducted in tertiary academic medical center. Medical records of 97 Muslim patients who were admitted to the IVF unit from May 2011-May 2021 were reviewed. Only men who provided at least one semen sample during Ramadan period (Ramadan month +70 days after)
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From national to international collaboration in GTD: hurdles and possibilities. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-10-12 Francois Golfier,Michael J Seckl
Today most women with gestational trophoblastic disease (GTD) can expect to be cured particularly if they live in middle to high income countries with access to GTD centres. In contrast, countries lacking organized GTD care achieve lower survival rates. This review considers some of the successes and areas for improvement in GTD care that have been achieved through national and international collaborations
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Surgical Management of Gestational Trophoblastic Disease. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-10-03 Leonoor Coopmans,Agnes Larsson,Ulrika Joneborg,Christianne Lok,Nienke van Trommel
Background Gestational Trophoblastic Disease (GTD) is a rare pregnancy related condition consisting of premalignant and malignant forms arising from proliferation of trophoblastic cells. The malignant forms are collectively referred to as Gestational Trophoblastic Neoplasia (GTN) and are highly sensitive to chemotherapy. However, surgical procedures remain indispensable in the diagnosis and treatment
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Revised Cut-Off Value of Human Epididymis Protein 4 Enhances its Use as an Ovarian Tumor Marker. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-10-03 Hiroki Machida,Takashi Hirakawa,Katsuhiko Tsunekawa,Takao Kimura,Masami Murakami,Yumiko Abe
OBJECTIVES Human epididymis protein 4 (HE4), a protein secreted by ovarian tumors, has been used as an ovarian tumor marker. This study aimed to improve the usefulness of HE4 to detect malignant ovarian tumors by reviewing the cut-off values. DESIGN Retrospective study without intervention Participants: One hundred forty nine healthy women (premenopausal, 126; postmenopausal, 23) and 24 patients with
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Carbetocin versus oxytocin with or without tranexamic acid for prophylactic prevention of postpartum hemorrhage after a vaginal delivery: A randomized clinical trial. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-09-30 Caglar Cetin,Fatma Basak Tanoglu,Erhan Hanligil,Ali Gokce,Ozge Pasin,Pinar Ozcan
OBJECTIVE Our study's primary objective was to examine the effects of four different prophylactic protocols on the prevention of postpartum hemorrhage following vaginal birth, including carbetocin only, oxytocin only, and a combination of carbetosin or oxytocin with tranexamic acid. DESIGN A multicentric randomized controlled trial. METHODS Participants/Materials, Setting, and Methods: This multicentric
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Clinical outcomes after the use of anti-adhesive agents in laparoscopic reproductive surgery. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-09-27 Sabine Esber,Andrea Etrusco,Antonio Simone Laganà,Vito Chiantera,Hafiz Muhammad Arsalan,Aline Khazzaka,Miriam Dellino,Zaki Sleiman
INTRODUCTION Intra-abdominal adhesions are abnormal fibrous attachments between tissues and organs that can be congenital or acquired. Adhesion formation is a critical postoperative complication that may lead to bowel obstruction, chronic abdominal pain and infertility. Physical barrier agents separate opposing peritoneal surfaces in the critical 5-day period of remesotheliazation. These agents are
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Delivery of a Fetus with a Non-reassuring Status is associated with Significant Maternal Morbidity. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-09-26 Ali Alhousseini,Carly Farr,Dotun Ogunyemi,Kurt Wharton,Aya Fawaz,Nagham Bazzi,Tonyie Andrews-Johnson,Ray Bahado-Singh
OBJECTIVES When a labor process is complicated by non-reassuring fetal status (NRFS), obstetricians focus on delivery to optimize neonatal status. We explored maternal morbidity in the setting of NRFS. Our hypothesis is that delivery of a live newborn with NRFS is associated with significant maternal morbidity. Design, participants, setting and methods: A large retrospective cohort study of 27,886
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The Microcirculation of Vaginal Tissue in Women with Obstetric Vesicovaginal Fistula and Short-Term Effects of Surgical Repair on Microvascular Parameters. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-09-21 Lennart P Maljaars,Arnoud W Kastelein,Yani P Latul,Gerald Nakoma,Ennet Chipungu,Jan-Paul W R Roovers,Rachel J Pope
OBJECTIVES The objective of the study was to better understand the extent of the ischemic trauma and the effects of surgical repair on the vaginal microcirculation in patients with obstetric vesicovaginal fistula (VVF). DESIGN In this observational study, we evaluated the vaginal microvasculature surrounding VVF using handheld vital microscopy (HVM) before, during, and 2 weeks after surgical VVF repair
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Immunotherapy for GTN: a new paradigm. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-09-13 Inge O Baas,Anneke M Westermann,Benoit You,Pierre-Adrien Bolze,Michael Seckl,Ehsan Ghorani
Background Immune checkpoint immunotherapy (CPI) targeting PD1/PD-L1 has been shown to be an effective treatment for gestational trophoblastic neoplasia (GTN). This includes those with multidrug resistance, ultra-high risk disease and ETT/PSTT subtypes that are inherently chemotherapy resistant, but there is also emerging evidence in low-risk disease. Objectives We set out to generate an overview of
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Letter on Genovese et al.'s "Impact of Hysterotomy Closure Technique on Subsequent Cesarean Scar Defects Formation: A Systematic Review". Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-08-30 Sanne I Stegwee,Carry Verberkt,Judith A F Huirne
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Risk of Reintervention or Postoperative Bleeding after Laparoscopy for Benign Gynecological Disease: A Clinical Prediction Model. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-08-21 Vesna Šalamun,Gaetano Riemma,Manca Pavec,Antonio Simone Laganà,Helena Ban Frangež
OBJECTIVE The objective of the study was to develop a clinically applicable prediction tool to early seek for postoperative major complications after laparoscopic surgery for benign pathologies. DESIGN Retrospective analysis of prospectively collected data was performed. SETTING The study was conducted at Tertiary Care University Hospital. PARTICIPANTS The participants of this study were reproductive-aged
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Belgian Fertility Clinic Staff Value Healthy Lifestyle Promotion but Lack Access to a Structured Lifestyle Modification Programme: An Observational Study. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-08-08 Tessy Boedt,Eline Dancet,Naomi Speelman,Carl Spiessens,Christophe Matthys,Sharon Lie Fong
OBJECTIVES Guidelines advise promoting a healthy lifestyle among patients with fertility problems as the lifestyle of women and men proved to be associated with their fertility. Australian fertility nurses were shown to lack access to structured lifestyle modification programmes, although they value healthy lifestyle promotion. This study aimed to examine whether gynaecologists also value promoting
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The Therapeutic Value of Adjuvant Chemotherapy after Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-07-27 Ya-Nan Wang,Mei-Ling Zhong,Mei-Rong Liang,Jian-Tong Yang,Si-Yuan Zeng
OBJECTIVE The aim of this study was to evaluate the therapeutic value and treatment-related complications of adjuvant chemotherapy after concurrent chemoradiotherapy (CCRT) for locally advanced cervical cancer (LACC). DESIGN The medical records of LACC patients who underwent CCRT were reviewed retrospectively. METHODS A total of 1,138 patients with LACC who had been treated at our hospital between
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In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-07-26 Marwan Habiba,Sun-Wei Guo,Giuseppe Benagiano
BACKGROUND The occurrence of vaginal bleeding in early neonatal life has been observed for centuries and was considered a consequence of the sudden drop in circulating hormones following birth. As such, neonatal uterine bleeding was dismissed as having no clinical significance. Interest in the phenomenon was renewed when a new theory suggested a link between neonatal uterine bleeding (NUB) and accelerated
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Diagnostic and Management Performance of ChatGPT in Obstetrics and Gynecology. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-07-26 Leila Allahqoli,Mohammad Matin Ghiasvand,Afrooz Mazidimoradi,Hamid Salehiniya,Ibrahim Alkatout
OBJECTIVES The use of artificial intelligence (AI) in clinical patient management and medical education has been advancing over time. ChatGPT was developed and trained recently, using a large quantity of textual data from the internet. Medical science is expected to be transformed by its use. The present study was conducted to evaluate the diagnostic and management performance of the ChatGPT AI model
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Chimeric Singleton Placenta Comprising Placental Mesenchymal Dysplasia and Complete Hydatidiform Mole with Live Birth and Postpartum Diagnosis of Gestational Trophoblastic Neoplasia. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-07-13 Seungyeon Song,Misung Kim,Ji Hye Koh,Ok Ju Kang,DaSol Oh,Sang-Hun Lee,Soo-Jeong Lee,Jun-Woo Ahn,Hyun-Jin Roh,Kyu-Rae Kim,Jeong Sook Kim
INTRODUCTION Placental mesenchymal dysplasia (PMD) is a benign lesion that is often misdiagnosed as complete (CHM) or partial hydatidiform mole. PMD usually results in live birth but can be associated with several fetal defects. Herein, we report PMD with CHM in a singleton placenta with live birth. CASE PRESENTATION A 34-year-old gravida 2, para 1, living 1 (G2P1L1) woman was referred on suspicion
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BIBR1532 Affects Endometrial Cell Proliferation, Migration, and Invasion in Endometriosis via Telomerase Inhibition and MAPK Signaling. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-07-10 Xiaoling Zhao,Dan Luo,Tingting Liu,He Zhang,Yunkai Xie,Weimin Kong
OBJECTIVES The effect of telomerase inhibitor BIBR1532 on endometriotic cells was investigated to explore the inhibitory effect of targeting telomerase on endometriosis. DESIGN In vitro primary cell culture study. Participants/Materials: Primary endometrial cells derived from eutopic and ectopic endometrium in patients with endometriosis. SETTING The study was conducted in the university hospital.
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Société Suisse de Gynécologie et d'Obstétrique (SGGG) Congress, 29 June - 1 July 2023. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-07-04
None.
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Dosing Characteristics of Recombinant Human Luteinizing Hormone or Human Menopausal Gonadotrophin-Derived LH Activity in Patients Undergoing Ovarian Stimulation: A German Fertility Database Study. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-06-27 Valerie Strezsak,Arthur Allignol,Klaus Bühler,Robert Fischer,Julie Hubbard,Salvatore Longobardi,Monica Lispi,Joan Schertz,Patrice Verpillat
OBJECTIVES The aim of the study was to evaluate dosing of recombinant human luteinizing hormone (r-hLH) or human menopausal gonadotrophin (hMG)-derived medications with LH activity in ovarian stimulation (OS) cycles for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). DESIGN A non-interventional study was performed to analyse data from the German RecDate database (January 2007-December
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Measurement of hCG in women with Gestational Trophoblastic Disease. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-06-12 Lesley M McMahon,Caroline M Joyce,Lyndsey Cuthill,Hugh Mitchell,Imran Jabbar,Fred Sweep,
OBJECTIVES The objective of this study was to collect information on human Chorionic Gonadotrophin (hCG) laboratory testing and reporting in women with Gestational Trophoblastic Disease (GTD), to assess the associated challenges, and to offer perspectives on hCG testing harmonisation. DESIGN Information was collected from laboratories by electronic survey (Survey Monkey®) using a questionnaire designed
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When to consult a geneticist specialising in gestational trophoblastic disease. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-05-26 Lesley McMahon,Geoffrey J Maher,Caroline Joyce,Isa Niemann,Rosemary Fisher,Lone Sunde
BACKGROUND Gestational trophoblastic disease comprises hydatidiform moles and a rare group of malignancies that derive from trophoblasts. Although there are typical morphological features that may distinguish hydatidiform moles from non-molar products of conception, such features are not always present, especially at early stages of pregnancy. Furthermore, mosaic/chimeric pregnancies and twin pregnancies
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Impact of Indication for Oocyte and Embryo Reception on Reproductive and Obstetric Outcomes. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-05-17 Matthias Boogaerts,Annemie Mengels,Sharon Lie Fong,Karen Peeraer,Carla Tomasseti,Arne Vanhie
OBJECTIVES This study aimed to assess if the indication for oocyte reception (OR) or embryo reception (ER) impacts the reproductive and obstetric outcomes by evaluating our experience at a tertiary fertility centre and by performing a literature review on this subject. Several previous studies have reported that, in contrast to other types of fertility treatment, the indication for OR/ER seems to have
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A Clinical Learning Curve Study of Polydimethylsiloxane Urolastic for Stress Urinary Incontinence: Does Safety Improve when Expertise Grow? Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-05-16 Fenne Casteleijn,Yani Latul,Rik van Eekelen,Jan-Paul Roovers
OBJECTIVES The aim of the study was to characterize the learning curve of bulk injection therapy polydimethylsiloxane Urolastic (PDMS-U) for stress urinary incontinence. DESIGN Secondary analysis from three clinical studies on efficacy and safety outcomes of PDMS-U was performed. PARTICIPANTS/MATERIALS, SETTING, METHODS PDMS-U-certified physicians who performed ≥4 procedures were included. The primary
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The Relation between Patient-Centered Care and Quality of Life in Women with Endometriosis. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-05-13 Anneke M F Schreurs,Eline A F Dancet,Silke Apers,Walter K H Kuchenbecker,Peter M van de Ven,Jacques W M Maas,Cornelis B Lambalk,Willianne L D M Nelen,Lisette E E van der Houwen,Velja Mijatovic
OBJECTIVE The objective of this study was to examine the hypothesis that experiences with patient-centered endometriosis care are related to the endometriosis-specific quality of life dimensions "emotional well-being" and "social support." DESIGN A secondary regression analysis of two cross-sectional studies was conducted. Participants/Materials: In total, data from 300 women were eligible for analysis
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Hysterectomy Using Vaginal Natural Orifice Transluminal Endoscopic Surgery Compared with Classic Laparoscopic Hysterectomy: A New Advantageous Approach? A Systematic Review on Surgical Outcomes. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-05-03 Christian Chaccour,Andrea Giannini,Tullio Golia D'Augè,Amal Ayed,Leila Allahqoli,Ibrahim Alkatout,Antonio Simone Laganà,Vito Chiantera,Ottavia D'Oria,Zaki Sleiman
INTRODUCTION Minimally invasive surgery aims to reduce surgical trauma and post-operative morbidity. Natural orifice transluminal endoscopic surgery is a safe and valid surgical option for hysterectomy. The present systematic review aims to compare hysterectomy by transvaginal natural orifice transluminal endoscopic surgery (vNOTES) with laparoscopic hysterectomy in terms of efficacy, surgical outcomes
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Gestational Trophoblastic Disease: Best Practice Nursing Guidelines Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-04-11 Kam Singh, Sarah Rollins, Jane Ireson
Background Clinical outcomes in gestational trophoblastic disease (GTD) are generally excellent, but GTD is a rare and complex condition that requires specialist information and support to offer a gold standard of care. Across Europe specialist nurses and/or midwives are increasingly common in the GTD multidisciplinary team to work alongside medical professionals in a holistic model of care, however
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Exploring the Safety Profile of Ornidazole as Drug Candidate for Endometriosis Treatment Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-04-04 Fabio Barra, Umberto Perrone, Angela Iasci, Simone Ferrero, Stefano Bogliolo
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Angiotensin converting enzyme (ACE) gene I/D polymorphism is significantly associated with insulin resistance and polycystic ovary syndrome: a meta-analysis Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-03-24 Jie Li, Zhong Lin, Shujia Wang, Qiuling Shi
Introduction: This study was performed to clarify the effects of angiotensin converting enzyme (ACE) I/D polymorphism on the risk of insulin resistance and polycystic ovary syndrome (PCOS). Methods: Six genotype models and the mean difference (MD)/standardized mean difference (SMD) were applied to evaluate the effects of ACE I/D polymorphism on insulin resistance and PCOS risk. Results: Thirteen studies
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Surgical Efficacy among Laparoscopic Ultrasonic Dissectors in adenomyosis Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-03-20 Mingjun Shao, Lanying Jin, Shunjie Zheng, Mingjun Shao, dawei Cui, Min Hu, Limei Ji
Objectives: The present study aimed to investigate the efficacy of ultrasonic dissectors for adenomyomectomy using the double/multiple-flap method combined with temporary occlusion of the temporary bilateral uterine artery and the utero-ovarian vessels for the treatment of symptomatic adenomyosis. Design:This was a retrospective study Participants/Materials: In total 162 patients with symptomatic adenomyosis
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Total flavonoids of Polygala fallax Hemsl induce apoptosis of human ectopic endometrial stromal cells through PI3K/AKT/Bcl-2 signaling pathway Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-03-17 Chuanmei Zhong, Gongchenhao Ju, Sufang Yang, xiangpei Zhao, Jixiang Chen, Ning Li
Abstract Objective: to explore the inhibitory effect of total flavonoids of Polygala fallax Hemsl (PFHF) on human ectopic endometrial stromal cells (HEcESCs) and its mechanism. Design: The potential targets and pathways of PFHF in the treatment of endometriosis were predicted by network pharmacology. The effect of PFHF on the proliferation, apoptosis and cell cycle, migration and invasion of HEcESCs
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Low-dose aspirin has antiproliferative and apoptosis effects in HPV-16 tumor cells and delays tumor-development and growth in an experimental model Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-03-07 Geny del Socorro Fierros Zárate, Fernando Luis Reyna Flores, Ana Isabel Burguete, Vicente Madrid Marina, Eduardo Guzmán Olea, Clarita Olvera Carranza, Celina García Melendrez, Victor Hugo Bermúdez Morales
Objectives: The purpose of this study is to investigate the effect of aspirin on epithelial HPV16-transformed cells and its anti-tumor effects, in an experimental HPV 16 positive tumor model. Design: The design of the study is experimental (in vitro and in vivo). Participants/Materials, Setting, and Methods: SiHa and BMK-16/myc cells were treated with aspirin and cell proliferation was determined by
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Expression of HMGB1-TLR4 in placentas from preeclamptic pregnancies and its effect on proliferation and invasion of HTR-8/SVneo cells Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-03-07 Lidan He, Qiongfang Song, Jifen Hu, Jianbo Wu
Objectives: Placental inflammation possibly underlies preeclampsia pathogenesis. This study aimed to investigate the expression of the high mobility box group 1 (HMGB1)-toll-like receptor 4 (TLR4) signalling pathway in preeclamptic placentas and determine whether HMGB1 regulates the biological behaviour of trophoblasts in vitro. Design: Placental biopsies were taken from 30 preeclamptic patients and
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Retraction Statement Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-02-08 T.M. D'Hooghe, Thomas M. D'Hooghe, Thomas D'Hooghe, Edgar Hernández-Andrade, Christina Bandera, George Condous, Togas Tulandi, Jan-Paul W.R. Roovers, Jacky Boivin, Gilbert G.G. Donders, Edgar Hernandez-Andrade, Lone Hummelshoj, Joris Vriens, Rohan D'Souza, Tim Van Mieghem, Lubna Pal, Viola Heinzelmann-Schwarz, David Mutch, Eva Dreisler, Hesham G. Al-Inany, Jan-Paul Roovers, Ole Bjarne Christiansen
Gynecol Obstet Invest
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Elevated IGF-1 induced female rats perpetuates the PCOS phenotype : Pathological mechanism of IGF-1 in polycystic ovary syndrome Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-02-02 Yuling Fu, Qian Sun, Kemiao Zhu, Chaofeng Hu
Objectives: This study was designated to establish a PCOS rat model with recombinant human insulin growth factor-1 (RH-IGF-1). We made assessment on the characteristics of hyperinsulinemia and hyperandrogenism in the rat model. Design: This study performed the characteristics of PCOS upon RH-IGF-1inejction and evaluated the disease process of PCOS syndrome caused by the insulin resistant pathological
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The impact of chronic endometritis on infertility: prevalence, reproductive outcomes, and the role of hysteroscopy as a screening tool Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-02-03 Brecht Geysenbergh, Anne-Sophie Boes, Celine Bafort, Anne-Sophie van Rompuy, Sara Neyens, Sharon Lie Fong, Sophie Debrock, Joris Vriens, Peter De Loecker, Eline Dancet, Thomas D'Hooghe, Karen Peeraer
Objectives: To study the prevalence of chronic endometritis (CE) in infertile women, its impact on reproductive outcomes, and the accuracy of hysteroscopy as a screening tool for CE. Design: Prospective observational study. Participants: 514 asymptomatic patients with infertility. Setting: Tertiary care center. Methods: The participants underwent a hysteroscopy and endometrial biopsy (EMB). Antibiotics
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Pretreatment of Dienogest for women with endometriosis in in vitro Fertilization: a systematic review and meta-analysis Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-02-03 Xueying Li, Jinli Lin, Linhao Zhang, Yao Liu
Introduction Dienogest (DNG) was demonstrated to be comparable to gonadotropin-releasing hormone agonist (GnRH-a) in controlling symptoms of endometriosis. GnRH-a is used before in vitro fertilization (IVF) in women with endometriosis to improve pregnancy outcomes. We aimed to determine the effect of DNG pretreatment on IVF outcomes, including number of mature oocytes, rate of clinical pregnancies
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Impact of hysterotomy closure technique on subsequent cesarean scar defects formation: a systematic review Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-02-01 Fortunato Genovese, Antonio Schiattarella, Gisella D’Urso, Salvatore Giovanni Vitale, Jose Carugno, Giovanna Verzì, Valentina D'Urso, Elisa Iacono, Stefano Siringo, Vito Leanza, Marco Palumbo
Introduction: The uterine caesarean scar defect, also known as uterine niche or isthmocele, is an irregularity in the anterior uterine wall at the site of a previous cesarean section scar. It is associated with obstetrical complications such as caesarean scar ectopic pregnancy, uterine rupture and, the placental accreta spectrum. Women with cesarean scar defects are frequently asymptomatic, but they
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Accuracy of IOTA simple rules, IOTA ADNEX model, RMI and subjective assessment for preoperative adnexal mass evaluation - the experience of a tertiary care referral hospital Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-30 Zoran Vilendecic, Milos Radojevic, Katarina Stefanovic, Jelena Dotlic, Ivana Likic-Ladjevic, Stefan Dugalic, Aleksandar Stefanovic
Objectives: The aim of this study was to evaluate the accuracy of IOTA Simple Rules (SR), IOTA ADNEX model, Risk of Malignancy Index (RMI), and subjective assessment (SA) which is used for adnexal mass assessment in our institution. Design: Prospective observational study. Participants/Materials, Setting, Methods: We included patients with at least one adnexal mass who needed elective surgical evaluation
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Comparing single-incision midurethral sling with bulking agents for female stress urinary incontinence: rationale for a non-randomised controled trial Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-30 Nienke Osse, Marit Schonewille, Marian Engberts, Marco Blanker, Wenche Klerkx, Hugo Van Eijndhoven
Objectives: Midurethral slings are considered the gold standard for the surgical treatment of stress-urinary incontinence (SUI), with an efficacy up to 80%. Another therapeutic option is the use of bulking agents, which create an artificial mass into the urethral submucosa, with an efficacy varying from 64% to 74%. Although bulking agents have a lower risk of complications than midurethral sling surgery
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Acknowledgement to reviewers Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-26
Gynecol Obstet Invest 2022;87:411–412
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Efficacy, adverse events, and challenges of Dienogest in the management of symptomatic adenomyosis: A comparison with different hormonal treatments Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-20 Hiroshi Kobayashi
Background Adenomyosis is an estrogen-dependent gynecologic condition that can cause pain symptoms, heavy menstrual bleeding, and infertility. Several treatments, including hormonal therapy can improve patients' quality of life through alleviating symptoms. Dienogest (DNG), a 19-norsteroid derivative oral progestin, is a promising treatment option for adenomyosis. Objectives This review aims to summarize
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Inhibition of ceramide kinase is effectively against cisplatin-resistant ovarian cancer cells by regulating ceramide and C1P levels Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-20 Jing Zou, Long Jian
Objective: Chemoresistance in ovarian cancer results in treatment failure, yet underlying mechanisms that regulate chemoresistance remain largely unclear. There is emerging evidence relating ovarian cancer drug resistance with bioactive sphingolipids and regulation of sphingolipid metabolism. This work investigated the expression and function of ceramide kinase (CerK), a lipid kinase that regulate
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Evaluation of a web-based intervention for patients with Gestational Trophoblastic Disease: a randomized controlled trial Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-20
Objective Gestational Trophoblastic Diseases (GTD) comprise a group of rare diseases originating from the trophoblast, affecting women of child-bearing age. Providing optimal information to patients with a rare disease is challenging, because of the small number of patients and limited clinical expertise of many healthcare professionals. Both knowledge and lack of knowledge in patients may influence
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Evaluation of a Web-Based Intervention for Patients with Gestational Trophoblastic Disease: A Randomized Controlled Trial. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-20 Minke Frijstein,Laura Blok,Marianne Ten Kate-Booij,Yalck Eysbouts,Nienke van Trommel,Fred Sweep,Leon Massuger,Dennis V Hamont,Henk Schreuder,Marieke Smink,Jan Molkenboer,Peggy Vencken,Nelleke Ottevanger,Christianne Lok,
OBJECTIVE Gestational trophoblastic diseases (GTD) comprise a group of rare diseases originating from the trophoblast affecting women of childbearing age. Providing optimal information to patients with a rare disease is challenging because of the small number of patients and limited clinical expertise of many healthcare professionals. Both knowledge and lack of knowledge in patients may influence illness
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COVID-19 quarantine and sexual function after first vaginal delivery Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-13 Ola Gutzeit, Dikla Ben Zvi, Gali Levy, Daniela Mazor, Roee Iluz, Lilia Tzur, Roy Lauterbach, Sima Dibbiny, Zeev Weiner, Lior Lowenstein
Objectives Sexual function is an important part of quality of life at all ages. Childbirth brings many changes that may affect sexual function. During quarantine due to the COVID-19 global pandemic, nuclear families were forced to stay home. The goal of this study was compere sexual function prior to the COVID-19 quarantine and during the quarantine, in postpartum couples in the first months following
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The Utility of Preoperative Serum CA125 Combined with HE4 to Predict Lymph Node Metastasis in Endometrial Cancer Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2023-01-03 Nisa Prueksaritanond, Sansanee Angsathapon, Putsarat Insin
Objectives: To investigate the diagnostic performance of the serum cancer antigen 125 (CA125), human epididymis protein 4 (HE4), a combination of CA125 and HE4, and a Risk of Ovarian Malignancy Algorithm (ROMA) in the preoperative prediction of high-risk lymph node metastasis in patients with early-stage endometrial cancer (EC). Designs: This is a cross-sectional study Participants/Materials, Setting
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OnabotulinumtoxinA Injections for the Treatment of Myofascial Pelvic Pain: 12-year Experience at a Tertiary Care Academic Center Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-12-28 Gregory Kirk Lewis, Aakriti R. Carrubba, Amanda P. Stanton, Emily C Craver, Zhuo Li, Anita H Chen
ABSTRACT OBJECTIVE: The aim of this study was to highlight the safety of OnabotulinumtoxinA (BTA) injections, with or without concurrent pudendal nerve block, in treating women with myofascial pelvic pain (MFPP). DESIGN: This was a retrospective cohort study. SETTING: Tertiary care academic center PARTICIPANTS/MATERIALS: We conducted a chart review of patients who were diagnosed with MFPP and treated
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LINC01857 exacerbates the malignant behaviors of endometrial carcinoma cells by sponging miR-19b-3p and recruiting ELAVL1 to up-regulate MYCN Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-12-27
Objectives: Long intergenic non-protein coding RNA 1857 (LINC01857) has been identified to play an oncogenic role in different cancers. Nevertheless, its expression and biological role in endometrial carcinoma (EC) are not clear. Design: Basic research on cell biology. Materials, Setting, Methods: EC cell lines were used in this study. RNA expressions in EC cells were examined through RT-qPCR. The
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Role of Protopine and Nuciferine in the management of nocturia, urgency and dysuria in pre- and post-menopausal women: a prospective pilot study. Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-12-19 Francesco Plotti, Adele Silvagni, Gianna Barbara Cundari, Fernando Ficarola, Carlo De Cicco Nardone, Federica Guzzo, Silvia Fabris, Daniela Luvero, Roberto Angioli, Corrado Terranova, Roberto Montera
Abstract Objectives: Nocturia was commonly treated with drugs burdened with high costs and numerous side effects; in fact, more than 70% of patients drop out of long-term treatment. Protopine and Nuciferine are two alkaloids that have different effects on the neurotransmitter receptors involved in the regulation mechanism of the onset of urinary stimuli. The aim of the study is to evaluate the efficacy
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Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-12-14 Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
Objectives: Metformin decreased circulating levels of anterior pituitary hormones and its effect on thyrotropin concentration was found to be stronger in individuals receiving myo-inositol. Phospholipids containing inositols are precursors of second messengers of several hormones, including gonadotropins and insulin. The aim of the current study was to investigate whether the concomitant use of myo-inositol
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Laparoscopic management of rudimentary uterine horns in patients with unicornuate uterus: a systematic review Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-12-05
Introduction: Unicornuate uterus is a rare Müllerian anomaly. Its potential association with a rudimentary uterine horn can cause a diagnostic delay. The most common consequences are pelvic pain, hematometra and endometriosis. Diagnosis of a unicornuate uterus is usually done by imaging combining ultrasound (US) and Magnetic Resonance Imaging (MRI). The aim of this systematic review is to assess the
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Meta-Analysis of Human Leukocyte Antigen-G 3′UTR Polymorphisms Confer Susceptibility to Recurrent Miscarriage Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-12-02 Xiaoyan Chen, Jun Zhang, Qiao Xu, Zhaoming Liu, Jun Chen, Yong Yang, Wei Zhou
Objectives: The current systematic review and meta-analysis have shown that specific HLA-G 3′ UTR variants are associated with recurrent miscarriage (RM). Our aim was to investigate the relevance of HLA-G 3′ UTR polymorphisms with the risk of RM. Design: A combined meta-analysis was implemented in this study. Participants/Materials, Setting, Methods: Common electronic databases including PubMed, Embase
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Establishment of the Dutch nationwide, interdisciplinary infrastructure and biobank for fundamental and translational ovarian cancer research: Archipelago of Ovarian Cancer Research (AOCR) Gynecol. Obstet. Invest. (IF 2.1) Pub Date : 2022-11-30 Hein S. Zelisse, Mignon van Gent, Sander de Ridder, Maaike A. van der Aa, Anne M. van Altena, Joost Bart, Jeroen A.M. Belien, Ingrid A. Boere, Steven L. Bosch, Annegien Broeks, Johan Bulten, Margriet Collée, Floris H. Groenendijk, Hugo Horlings, Maurice P.H.M. Jansen, G.N. Jonges, Loes Kooreman, Cornelis D. de Kroon, Sandrina Lambrechts, Christianne Lok, Jurgen M. Piek, Anna K.L. Reyners, Eva-Maria
Objectives: Ovarian cancer has the worst overall survival rate of all gynecologic malignancies. For the majority of patients, the 5-year overall survival rate of less than 50% has hardly improved over the last decades. To improve the outcome of patients with all subtypes of ovarian cancer, large-scale fundamental and translational research is needed. To accommodate these types of ovarian cancer research