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Pregnancy and obstetric outcomes of dichorionic triamniotic triplet pregnancies with selective foetal reduction after assisted reproductive technology Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-03-15 Shuhua Liu, Qianhua Xu, Dehong Liu, Qiuru Li, Jingyu Qian, Bin Zhang, Xianxia Chen
It is generally beneficial and recommended that dichorionic triamniotic (DCTA) triplet pregnancies be reduced to monochorionic (MC) twin or singleton pregnancies after assisted reproductive technology (ART). However, some infertile couples still have a firm desire to retain twins. For this reason, the best foetal reduction strategies need to be available for infertile couples and clinicians. Given
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Active plasma renin concentration throughout healthy and complicated pregnancy: a systematic review and meta-analysis Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-03-07 Wisal El Fathi, Maaike van Ochten, Munieb Rehman, Sander M. J. van Kuijk, Joanna IntHout, Chahinda Ghossein-Doha, Sander de Haas, Marc E. A. Spaanderman, Joris van Drongelen
Pregnancy is characterized by profound circulatory changes and compensatory adjustments in the renin-angiotensin-aldosterone system (RAAS). Differences in regulatory response may antedate or accompany vascular complicated pregnancy. We performed a systematic review and meta-analysis to delineate the trajectory of active plasma renin concentration (APRC) in healthy pregnancy and compare this to complicated
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Flagellar beating forces of human spermatozoa with different motility behaviors Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-03-06 Cristina Tufoni, Alice Battistella, Stefania Luppi, Rita Boscolo, Giuseppe Ricci, Marco Lazzarino, Laura Andolfi
One of the causes of male infertility is associated with altered spermatozoa motility. These sperm features are frequently analyzed by image-based approaches, which, despite allowing the acquisition of crucial parameters to assess sperm motility, they are unable to provide details regarding the flagellar beating forces, which have been neglected until now. In this work we exploit Fluidic Force Microscopy
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Assessment of artificial intelligence model and manual morphokinetic annotation system as embryo grading methods for successful live birth prediction: a retrospective monocentric study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-03-05 Myrto-Sotiria Papamentzelopoulou, Ilectra-Niki Prifti, Despoina Mavrogianni, Thomais Tseva, Ntilay Soyhan, Aikaterini Athanasiou, Antonia Athanasiou, Adamantios Athanasiou, Paraskevi Vogiatzi, George Konomos, Dimitrios Loutradis, Maria Sakellariou
The introduction of the time-lapse monitoring system (TMS) and the development of predictive algorithms could contribute to the optimal embryos selection for transfer. Therefore, the present study aims at investigating the efficiency of KIDScore and iDAScore systems for blastocyst stage embryos in predicting live birth events. The present retrospective study was conducted in a private IVF Unit setting
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Effect of frozen-thawed embryo transfer with a poor-quality embryo and a good-quality embryo on pregnancy and neonatal outcomes Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-21 Cheng Zeng, Rui-Hui Lu, Xin Li, Sheng Wang, Yan-Rong Kuai, Qing Xue
To evaluate the impact of embryo quality and quantity, specifically a poor quality embryo (PQE) in combination with a good quality embryo (GQE), by double embryo transfer (DET) on the live birth rate (LBR) and neonatal outcomes in patients undergoing frozen-thawed embryo transfer (FET) cycles. A study on a cohort of women who underwent a total of 1462 frozen-thawed cleavage or blastocyst embryo transfer
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Evaluation of serum adiponectin as a marker of insulin resistance in women with polycystic ovarian syndrome: a comparative cross-sectional study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-20 Olugbenga Ojatokunbo Runsewe, Abiodun Adeniyi Adewunmi, Gbenga Olorunfemi, Abimbola Tawaqualit Ottun, Ayokunle Moses Olumodeji, Babalola Ogungbemile, Tamramat Iyabo Runsewe-Abiodun
Insulin resistance (IR) is known to be prevalent amongst women with polycystic ovarian syndrome (PCOS). Its presence has been linked to chronic anovulation and marked long term complications in women. Hence, identification and treatment of IR in women with PCOS is required to prevent the metabolic and reproductive complications of the disease. The aim of this study is to determine if serum adiponectin
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Deconvolution at the single-cell level reveals ovarian cell-type-specific transcriptomic changes in PCOS Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-19 Shumin Li, Yimeng Li, Yu Sun, Gengchen Feng, Ziyi Yang, Xueqi Yan, Xueying Gao, Yonghui Jiang, Yanzhi Du, Shigang Zhao, Han Zhao, Zi-Jiang Chen
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders in females of childbearing age. Various types of ovarian cells work together to maintain normal reproductive function, whose discordance often takes part in the development and progression of PCOS. Understanding the cellular heterogeneity and compositions of ovarian cells would provide insight into PCOS pathogenesis
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The reproductive potential of vitrified-warmed euploid embryos declines following repeated uterine transfers Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-13 A. Almohammadi, F. Choucair, L. El Taha, H. Burjaq, M. Albader, A. B. Cavanillas, Johnny T. Awwad
Recurrent implantation failure (RIF) represents a vague clinical condition with an unclear diagnostic challenge that lacks solid scientific underpinning. Although euploid embryos have demonstrated consistent implantation capabilities across various age groups, a unanimous agreement regarding the advantages of preimplantation genetic testing for aneuploidy (PGT-A) in managing RIF is absent. The ongoing
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‘Intracytoplasmic sperm injection (ICSI) paradox’ and ‘andrological ignorance’: AI in the era of fourth industrial revolution to navigate the blind spots Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-13 Pallav Sengupta, Sulagna Dutta, Ravindran Jegasothy, Petr Slama, Chak-Lam Cho, Shubhadeep Roychoudhury
The quandary known as the Intracytoplasmic Sperm Injection (ICSI) paradox is found at the juncture of Assisted Reproductive Technology (ART) and ‘andrological ignorance’ – a term coined to denote the undervalued treatment and comprehension of male infertility. The prevalent use of ICSI as a solution for severe male infertility, despite its potential to propagate genetically defective sperm, consequently
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An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-10 Axelle Brulport, Mathilde Bourdon, Daniel Vaiman, Christian Drouet, Khaled Pocate-Cheriet, Kheira Bouzid, Louis Marcellin, Pietro Santulli, Carole Abo, Maxime Jeljeli, Sandrine Chouzenoux, Charles Chapron, Frédéric Batteux, Camille Berthelot, Ludivine Doridot
Biomarker identification could help in deciphering endometriosis pathophysiology in addition to their use in the development of non invasive diagnostic and prognostic approaches, that are essential to greatly improve patient care. Despite extensive efforts, no single potential biomarker or combination has been clinically validated for endometriosis. Many studies have investigated endometriosis-associated
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Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-03 Hailun Liu, André Franken, Alexandra P. Bielfeld, Tanja Fehm, Dieter Niederacher, Zhongping Cheng, Hans Neubauer, Nadia Stamm
Decidualization of endometrial cells is the prerequisite for embryo implantation and subsequent placenta formation and is induced by rising progesterone levels following ovulation. One of the hormone receptors contributing to endometrial homeostasis is Progesterone Receptor Membrane Component 1 (PGRMC1), a non-classical membrane-bound progesterone receptor with yet unclear function. In this study,
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Impact of oil-based contrast agents in hysterosalpingography on fertility outcomes in endometriosis: a retrospective cohort study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-03 Baoli Xie, Yingqin Huang, Fu Hang, Jiaxin Yu, Qianwen Hu, Jiaxu Li, Aiping Qin
Previous studies have suggested that oil-based contrast agents used during hysterosalpingography (HSG) in infertile patients can enhance fertility. However, limited research has investigated the effect of oil-based contrast medium specifically in individuals with endometriosis-related infertility. This study aims to explore the impact of oil-based contrast medium on fertility outcomes in women with
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Outpatient hysteroscopy impact on subsequent assisted reproductive technology: a systematic review and meta-analysis in patients with normal transvaginal sonography or hysterosalpingography images Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-01 Jung-Hsiu Hou, Buo-Jia Lu, Ya-Li Huang, Chih-Heng Chen, Chi-Huang Chen
Standard management for intrauterine lesions typically involves initial imaging followed by operative hysteroscopy for suspicious findings. However, the efficacy of routine outpatient hysteroscopy in women undergoing assisted reproductive technology (ART) remains uncertain due to a lack of decisive high-quality evidence. This study aimed to determine whether outpatient hysteroscopy is beneficial for
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miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4 Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-02-01 Wenhan Ju, Shuai Zhao, Haicui Wu, Yi Yu, Yuan Li, Danqi Liu, Fang Lian, Shan Xiang
In our previous investigation, we revealed a significant increase in the expression of microRNA-6881-3p (miR-6881-3p) in follicular fluid granulosa cells (GCs) from women with diminished ovarian reserve (DOR) compared to those with normal ovarian reserve (NOR). However, the role of miR-6881-3p in the development of DOR remains poorly understood. This study aimed to elucidate the involvement of miR-6881-3p
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MiR-124-3p negatively impacts embryo implantation via suppressing uterine receptivity formation and embryo development Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-31 Kezhen Yao, Quanmin Kang, Kai Chen, Biwei Shi, Xiaofen Jin
During embryo implantation, blastocyst interacts with the receptivity endometrium and the endometrial epithelium secretes nurturing fluid to support embryonic development. Interferon-λ (IFN-λ) is a novel, non-redundant regulator that participates in the fetal–maternal interaction; however, the precise molecular mechanism underlying its impact on uterine receptivity remains elusive. Here, microarray
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Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3α, improves sperm motility Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-22 Seung Hyun Park, Myung Chan Gye
Cyclophilin D (CypD) negatively regulates ATP production by opening of the mitochondrial permeability transition pore. This study aimed to understand the role of CypD in sperm motility regulation. Changes in CypD during sperm capacitation and its interaction with glycogen synthase kinase 3α (GSK3α), a key kinase regulating sperm motility, were examined in mouse spermatozoa. The effects of CypD inhibitor
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Serum erythropoietin level is increased during stimulation for IVF but not in OHSS Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-20 Merituuli Rekola, Kati Korhonen, Leila Unkila-Kallio, Henrik Alfthan, Vedran Stefanovic, Aila Tiitinen, Tomi S. Mikkola, Hanna Savolainen-Peltonen
Erythropoietin (Epo) is a potent vascular growth factor that induces angiogenesis and antiapoptotic signalling. We investigated whether the development of numerous follicles and corpora lutea during in vitro fertilization (IVF) cycle affects circulating Epo levels and further, if Epo could be used as a novel marker for ovarian hyperstimulation syndrome (OHSS). 24 women were included in the uncomplicated
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Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-18 Ziwei Zhou, Yifei Feng, Lishan Xie, Song Ma, Zhaoxia Cai, Ying Ma
Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis
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Associations between the artificial intelligence scoring system and live birth outcomes in preimplantation genetic testing for aneuploidy cycles Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-17 Chun-I Lee, Chun-Chia Huang, Tsung-Hsien Lee, Hsiu-Hui Chen, En-Hui Cheng, Pin-Yao Lin, Tzu-Ning Yu, Chung-I Chen, Chien-Hong Chen, Maw-Sheng Lee
Several studies have demonstrated that iDAScore is more accurate in predicting pregnancy outcomes in cycles without preimplantation genetic testing for aneuploidy (PGT-A) compared to KIDScore and the Gardner criteria. However, the effectiveness of iDAScore in cycles with PGT-A has not been thoroughly investigated. Therefore, this study aims to assess the association between artificial intelligence
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Intra-ovarian inflammatory states and their associations with embryo quality in normal-BMI PCOS patients undergoing IVF treatment Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-11 Jie Shang, Siyu Wang, Aiyuan Wang, Fang Li, Jing Zhang, Jin Wang, Rui Lv, Haixia Chen, Xiaohuan Mu, Kai Zhang, Xiaohong Bai, Ye Tian
Polycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility in women of reproductive age, and low-grade chronic inflammation plays a key role in the occurrence and development of PCOS. However, obesity, as a likely confounding factor, can affect the inflammatory state of PCOS patients. The aim of this study was to comprehensively investigate intra-ovarian inflammatory states and their
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Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-09 Elena Juárez-Barber, Ana Corachán, María Cristina Carbajo-García, Amparo Faus, Carmen Vidal, Juan Giles, Antonio Pellicer, Irene Cervelló, Hortensia Ferrero
Women with adenomyosis are characterized by having defective decidualization, impaired endometrial receptivity and/or embryo-maternal communication, and implantation failure. However, the molecular mechanisms underlying adenomyosis-related infertility remain unknown, mainly because of the restricted accessibility and the difficult preservation of endometrial tissue in vitro. We have recently shown
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Diagnosis and management of infertility: NICE-adapted guidelines from the Italian Society of Human Reproduction Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-05 Stefano Palomba, Paola Viganò, Sandrine Chamayou, Zaira Donarelli, Maria Paola Costantini, Roberto Marci, Paola Piomboni, Egidio Fino, Luigi Montano, Antonino Guglielmino, Edgardo Somigliana
In Italy the fertility rate is very low, and an increasing number of patients are infertile and require treatments. The Italian Law concerning the safety of patient care, and the professional liability of health professionals, indicates that health professionals must comply with the recommendations set out in the guidelines developed by public and private bodies and institutions, as well as scientific
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Outcomes of BRCA pre-implantation genetic testing according to the parental mutation origin: a cohort study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-03 Ilana Weizel, Tal Shavit, Yulia Shuli, Chana Adler Lazarovich, Rivka Halevi, Tal Ben Ari, Shira Yaacobi-Artzi, Yaakov Bentov, Baruch Feldman, Anat Hershko Klement
The process of gamete formation and early embryonic development involves rapid DNA replication, chromosome segregation and cell division. These processes may be affected by mutations in the BRCA1/2 genes. The aim of this study was to evaluate BRCA mutation inheritance and its effect on early embryonic development according to the parental origin of the mutation. The study question was approached by
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Follitropin delta combined with menotropin in patients at risk for poor ovarian response during in vitro fertilization cycles: a prospective controlled clinical study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Oscar Barbosa Duarte-Filho, Eduardo Hideki Miyadahira, Larissa Matsumoto, Lucas Yugo Shiguehara Yamakami, Renato Bussadori Tomioka, Sergio Podgaec
The maximum daily dose of follitropin delta for ovarian stimulation in the first in vitro fertilization cycle is 12 μg (180 IU), according to the algorithm developed by the manufacturer, and based on patient’s ovarian reserve and weight. This study aimed to assess whether 150 IU of menotropin combined with follitropin delta improves the response to stimulation in women with serum antimullerian hormone
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Long pentraxin 3 and vitamin D receptor mRNA expression pattern of cumulus granulosa cells isolated from PCOS oocytes at different stages of nuclear maturation Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Aynur Ersahin, Onder Celik, Nur D. Gungor, Nilufer Celik, Sureyya Melil, Meltem Yardim, Semih Dalkilic, Cenk Ersahin, Ece Dogukargin, Sudenaz Celik, Ramazan F. Akkoc
A fine-tuned pro-inflammatory and anti-inflammatory balance in the follicular unit is essential for cumulus expansion and successful ovulation. While the long pentraxin 3 (PTX3) gene is required for the expansion of cumulus cells (CCs), ovulation, resumption of meiosis and fertilization, the vitamin D receptor gene (VDR-X2) is required for intra-follicle redox balance. This study was planned to determine
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NET1 is a critical regulator of spindle assembly and actin dynamics in mouse oocytes Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Shiwei Wang, Xuan Wu, Mengmeng Zhang, Siyu Chang, Yajun Guo, Shuang Song, Shizhen Dai, Keliang Wu, Shenming Zeng
Neuroepithelial transforming gene 1 (NET1) is a RhoA subfamily guanine nucleotide exchange factor that governs a wide array of biological processes. However, its roles in meiotic oocyte remain unclear. We herein demonstrated that the NET1-HACE1-RAC1 pathway mediates meiotic defects in the progression of oocyte maturation. NET1 was reduced using a specific small interfering RNA in mouse oocytes. Spindle
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The association between serum testosterone level and congestive heart failure in US male adults: data from National Health and Nutrition Examination Survey (NHANES) 2011–2016 Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Xiangpeng Zhan, Yang Liu, Tao Chen, Hao Wan, Situ Xiong, Sheng Li, Xinxi Deng, Luyao Chen, Bin Fu
This study aimed to investigate the relationship between serum testosterone levels and the risk of congestive heart failure (CHF) in adult males. Previous research has suggested a potential link between serum testosterone and cardiovascular health, but the findings have been inconclusive. This study was cross-sectional, and the data were obtained from the 2011–2016 cycle of the National Health and
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Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Daiji Kiyozumi
The maturation of spermatozoa is a regulated process, influenced by genes expressing essential secreted proteins in the proximal epididymis. Recent genetic studies in rodents have identified the non-sex steroidal molecular signals that regulate gene expression in the proximal epididymis. Germ cells in the testis secrete ligand proteins into the seminiferous tubule lumen The ligand proteins travel through
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Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Lihong Wang, Zhoujunhao Zhou, Xinming Xu, Yue Li, Rui Zhang, Zhiyan Yu, Xinmei Huang, Shufei Zang, Tiange Sun
Chronic inflammation plays a vital role in the development of gestational diabetes mellitus (GDM). Studies in mouse models show that neutrophil serine proteases (NSPs), neutrophil elastase (NE) and proteinase-3 (PR3) are important drivers of chronic inflammation with consequent metabolic disturbances. This study evaluated the association of NE and PR3 with GDM development and adverse fetal outcomes
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The impact of COVID-19 on the mental and sexual health of patients with infertility: a prospective before-and-after study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2024-01-02 Jing Qi, Meng Sun, Xingchen Yue, Xintong Hong, Meng Dong, Jichun Tan
The coronavirus disease (COVID-19) pandemic has seriously impacted the mental and sexual health of the general population. Patients dealing with infertility constitute a unique subset within society, susceptible to heightened sensitivity amid pressures and crises. However, to the best of our knowledge, the impact of the different stages of the COVID-19 pandemic on the mental and sexual health of patients
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Can AMH levels predict the need to step up FSH dose for controlled ovarian stimulation following a long GnRH agonist protocol in PCOS women? Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-18 Hui Huang, Haijie Gao, Yingying Shi, Bingbing Deng, Xuemei He, Jin Lin, Ping Li
To explore the role of anti-Mullerian hormone (AMH) in predicting the need to step up recombinant FSH (rFSH) dose following long GnRH agonist protocol in IVF/ICSI cycles of polycystic ovarian syndrome (PCOS) women. This is a retrospective cohort study of 825 PCOS women undergoing long GnRH agonist protocol enrolled from Jan 2019 to Dec 2021. The daily rFSH dose at which the first response to rFSH were
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Assessing the impact of transplant site on ovarian tissue transplantation: a single-arm meta-analysis Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-12 Baoli Xie, Jiaxu Li, Yingqin Huang, Fu Hang, Qianwen Hu, Jiaxin Yu, Aiping Qin
Survival rates of young women undergoing cancer treatment have substantially improved, with a focus on post-treatment quality of life. Ovarian tissue transplantation (OTT) is a viable option to preserve fertility; however, there is no consensus on the optimal transplantation site. Most studies on OTT are nonrandomized controlled trials with limited sample sizes and uncontrolled statistical analyses
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Comparison of clinical effectiveness and subsequent fertility between hysteroscopic resection and vaginal repair in patients with cesarean scar defect: a prospective observational study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-11 Guoxia Yang, Jiamin Wang, Yajie Chang, Yuqing Chen
To evaluate the clinical effectiveness and pregnancy rate after hysteroscopic resection (HR) and/or vaginal repair (VR) in patients with cesarean scar defect (CSD). This prospective observational study enrolled 191 patients who received CSD surgery in the First affiliated hospital of Sun Yat-sen University between September 2019 to February 2022 (96 in HR and 95 in VR, respectively). Patient follow-up
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Correlation between controlled ovarian stimulation protocols and euploid blastocyst rate in pre-implantation genetic testing for aneuploidy cycles Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-06 Bixia Huang, Hui Li, Bin Xu, Ning Li, Xiaofei Wang, Yanping Li, Jing Zhao
Several studies have explored which COS protocol yields a higher blastocyst euploidy rate, but findings have been inconsistent. The present study aimed to explore whether controlled ovarian stimulation (COS) protocols was associated with euploid blastocyst rate in pre-implantation genetic testing for aneuploidy (PGT-A) cycles. The study was a retrospective study where data were obtained from three
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hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-06 Victoria G. Wesevich, Serin I. Seckin, Dawn A. Kelk, Amanda N. Kallen, Pinar H. Kodaman
Premature progesterone (P) rise during IVF stimulation reduces endometrial receptivity and is associated with lower pregnancy rates following embryo transfer (ET), which can influence provider recommendation for fresh or frozen ET. This study aimed to determine whether change in P level between in IVF baseline and trigger (��P) is predictive of pregnancy outcome following fresh ET, and whether the
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Y chromosome microdeletions in Chinese men with infertility: prevalence, phenotypes, and intracytoplasmic sperm injection outcomes Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-05 Dongjia Chen, Guoqing Fan, Xianqing Zhu, Qinyun Chen, Xuren Chen, Feng Gao, Zexin Guo, Peng Luo, Yong Gao
The incidence of Y chromosome microdeletions varies among men with infertility across regions and ethnicities worldwide. However, comprehensive epidemiological studies on Y chromosome microdeletions in Chinese men with infertility are lacking. We aimed to investigate Y chromosome microdeletions prevalence among Chinese men with infertility and its correlation with intracytoplasmic sperm injection (ICSI)
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25(OH)D3 improves granulosa cell proliferation and IVF pregnancy outcomes in patients with endometriosis by increasing G2M+S phase cells Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-12-05 Rui Hu, Leilei Li, Lanlan Liang, YuXin Qi, Xiaoling Ma, Yuan Yang
The 25-hydroxyvitamin D3 (25 (OH) D3) is crucial for follicular development. This study aimed to investigate the relationship between the level of 25 (OH) D3 in endometriosis patients, pregnancy outcomes of in vitro fertilization (IVF), and the underlying mechanism. The 25 (OH) D3 levels in serum and follicular Fluid (FF) samples were detected using enzyme-linked immunosorbent assay (ELISA). Clinical
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Multi-omics study identifies that PICK1 deficiency causes male infertility by inhibiting vesicle trafficking in Sertoli cells Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-25 Jing Jin, Kaiqiang Li, Yaoqiang Du, Fang Gao, Zhen Wang, Weixing Li
Infertility affects approximately 10–15% of reproductive-age men worldwide, and genetic causes play a role in one-third of cases. As a Bin-Amphiphysin-Rvs (BAR) domain protein, protein interacting with C-kinase 1 (PICK1) deficiency could lead to impairment of acrosome maturation. However, its effects on auxiliary germ cells such as Sertoli cells are unknown. The present work was aimed to use multi-omics
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Association of insulin resistance with polycystic ovary syndrome phenotypes and patients’ characteristics: a cross-sectional study in Iran Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-25 Leili Rahmatnezhad, Lida Moghaddam-Banaem, Tahereh Behroozi-Lak, Afshin Shiva, Javad Rasouli
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. This disorder affects 6–15% of women of childbearing age worldwide. It is diagnosed with hyperandrogenism, polycystic ovaries, and chronic anovulation with insulin resistance. This study aimed to assess the prevalence of insulin resistance (IR) in 4 phenotypes of PCOS, and its relationship with demographic, clinical, and
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Pregnancy prediction via ultrasound-detected endometrial blood for hormone replacement therapy-frozen embryo transfer: a prospective observational study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-24 Xue Ke, Xue-fei Liang, Yong-hong Lin, Fang Wang
This study aimed to assess the predictive value of endometrial blood flow branches on pregnancy outcomes after hormone replacement therapy-frozen embryo transfer (HRT-FET). This prospective observational study involved 292 reproductive-aged women who underwent endometrial receptivity assessment in a tertiary care academic medical center in southwest China using power Doppler ultrasonography during
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A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-23 Awoniyi O. Awonuga, Olivia G Camp, Husam M Abu-Soud
Polycystic ovary syndrome (PCOS) is a heterogeneous functional endocrine disorder associated with a low-grade, chronic inflammatory state. Patients with PCOS present an increased risk of metabolic comorbidities and often menstrual dysregulation and infertility due to anovulation and/or poor oocyte quality. Multiple mechanisms including oxidative stress and low-grade inflammation are believed to be
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In vitro maturation (IVM) of human immature oocytes: is it still relevant? Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-22 Mausumi Das, Weon-Young Son
In vitro maturation (IVM) of human immature oocytes has been shown to be a viable option for patients at risk of ovarian hyperstimulation syndrome (OHSS), those seeking urgent fertility preservation and in circumstances where controlled ovarian stimulation is not feasible. Moreover, IVM techniques can be combined with ovarian tissue cryobanking to increase the chances of conception in cancer survivors
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Nuclear-cytoplasmic asynchrony in oocyte maturation caused by TUBB8 variants via impairing microtubule function: a novel pathogenic mechanism Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-22 Tianli Chang, Jing Zhao, Qi Li, Anning Meng, Qiuping Xia, Yanping Li, Wenpei Xiang, Zhongyuan Yao
TUBB8, a crucial gene encoding microtubule protein, plays a pivotal role in cellular processes. Deleterious TUBB8 variants have been shown to significantly hinder oocyte maturation. In this study, we conducted an in vitro investigation using TUBB8 mutant mouse oocytes to elucidate the pathogenic mechanisms of TUBB8 variants in oocyte nuclear and cytoplasmic maturation. A mutant model was successfully
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Thyroid hormone transport and metabolism are disturbed in the placental villi of miscarriage Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-15 Zhen Yu, Xinghao Feng, Zhongshan Lin, Xuan Li, Shiyue Su, Huiru Cheng, Yuanyuan Yang, Zhaolian Wei
It has been long known that thyroid hormone regulates placental villi development, which is associated with the occurrence of miscarriage. However, whether abnormal thyroid hormone metabolism and transport in placental villi are involved in miscarriage is still to be verified. Placental villi of elective terminations of pregnancies (ETPs) and miscarriage were collected. Proliferative activity and apoptosis
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Endometriosis and IVF treatment outcomes: unpacking the process Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-07 Edgardo Somigliana, Letizia Li Piani, Alessio Paffoni, Noemi Salmeri, Michele Orsi, Laura Benaglia, Paolo Vercellini, Paola Vigano’
Advanced endometriosis is associated with a reduction of IVF success. Surgical damage to the ovarian reserve following the excision of endometriomas has been claimed as a critical factor in the explanation of this detrimental effect. However, it is generally inferred that other mechanisms might also hamper IVF success in affected women. They include diminished responsiveness to ovarian stimulation
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Small RNAs, spermatogenesis, and male infertility: a decade of retrospect Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-11-04 Meghali Joshi, Shruti Sethi, Poonam Mehta, Anamika Kumari, Singh Rajender
Small non-coding RNAs (sncRNAs), being the top regulators of gene expression, have been thoroughly studied in various biological systems, including the testis. Research over the last decade has generated significant evidence in support of the crucial roles of sncRNAs in male reproduction, particularly in the maintenance of primordial germ cells, meiosis, spermiogenesis, sperm fertility, and early post-fertilization
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Body mass index impacts ectopic pregnancy during in vitro fertilization: an analysis of 42,362 clinical pregnancy cycles Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-31 Xiaofei Ge, Keyan Wang, Yingpu Sun, Zhiqin Bu
This large, single-center, retrospective cohort study was aimed to explore the effect of female body mass index (BMI) on ectopic pregnancy (EP) following fresh and frozen-thawed embryo transfers (ET). A total of 27,600 pregnancies after fresh ET and 14,762 pregnancies after frozen-thawed ET were included between January 2010 to June 2022. Women were divided into three groups based on BMI according
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Correction: Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-31 Xiaoyan Qin, Wenjing Sun, Chong Wang, Mingjiang Li, Xingbo Zhao, Changzhong Li, Hui Zhang
Correction: Reprod Biol Endocrinol 19, 114 (2021) https://doi.org/10.1186/s12958-021-00800-6 Following publication of the original article [1], the authors identified an error in Fig. 2. The correct figure is given below. Fig. 2 Immunoexpression and comparison of B7-H3 in normal, eutopic and ectopic endometrium of adenomyosis treated with and without mifepristone. a Ectopic endometrium of proliferative
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Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-31 Bichun Guo, Sainan Zhang, Shanshan Wang, Huidan Zhang, Junshun Fang, Nannan Kang, Xin Zhen, Yang Zhang, Jidong Zhou, Guijun Yan, Haixiang Sun, Lijun Ding, Chuanming Liu
With advanced maternal age, abnormalities during oocyte meiosis increase significantly. Aneuploidy is an important reason for the reduction in the quality of aged oocytes. However, the molecular mechanism of aneuploidy in aged oocytes is far from understood. Histone acetyltransferase 1 (HAT1) has been reported to be essential for mammalian development and genome stability, and involved in multiple
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Evaluating the risk of endometriosis based on patients’ self-assessment questionnaires Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-28 Krystian Zieliński, Dajana Drabczyk, Michał Kunicki, Damian Drzyzga, Anna Kloska, Jacek Rumiński
Endometriosis is a condition that significantly affects the quality of life of about 10 % of reproductive-aged women. It is characterized by the presence of tissue similar to the uterine lining (endometrium) outside the uterus, which can lead lead scarring, adhesions, pain, and fertility issues. While numerous factors associated with endometriosis are documented, a wide range of symptoms may still
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Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-27 Xiaojuan Wang, Yuan Li, Hongzhuan Tan, Sufen Cai, Shujuan Ma, Yangqin Peng, Hui Guo, Xiaofeng Li, Yi Tang, Shunji Zhang, Ge Lin, Fei Gong
The current routine endometrial preparation protocol for women with polycystic ovary syndrome (PCOS) is hormone replacement treatment (HRT). Letrozole is rarely used in frozen embryo cycles. Evidence confirming whether letrozole-stimulated (LS) protocol is suitable for frozen embryo transfer in patients with PCOS and for whom is suitable remains lacking. This was a retrospective cohort study involving
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Live birth rates after resolution of endometrial cavity fluid in frozen embryo transfer cycles Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-27 Vincent Nguyen, Aaron Jackson, Jenna Gale
Are live birth rates affected in frozen embryo transfer cycles that develop transient endometrial cavity fluid that resolves by day of embryo transfer? The first frozen blastocyst transfer cycle between January 1st, 2016 and December 31st, 2019 were included in this retrospective cohort study at an academic fertility center. The presence or absence of endometrial cavity fluid (ECF) detected on initial
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METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-27 Xiaoou Li, Jie Jin, Xuefeng Long, Ruiwen Weng, Wenqian Xiong, Jiaxin Liang, Junjun Liu, Jingwen Sun, Xueqin Cai, Ling Zhang, Yi Liu
Endometriosis-related infertility is a common worldwide reproductive health concern. Despite ongoing research, the causes of infertility remain unclear. Evidence suggests that epigenetic regulation is crucial in reproduction. However, the role of N6-methyladenosine (m6A) modification of RNA in endometriosis-related infertility requires further investigation. We examined the expression of m6A and m
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Application of elastography to diagnose adenomyosis and evaluate the degree of dysmenorrhea: a prospective observational study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-26 Qianhui Ren, Xiangyi Dong, Ming Yuan, Xue Jiao, Hao Sun, Zangyu Pan, Xinyu Wang, Guowei Tao, Wang Guoyun
To determine whether there is a correlation between stiffness measured by strain elastography and the severity of dysmenorrhea and to determine the value of elastography in evaluating severe dysmenorrhea in patients with adenomyosis. The correlation between tissue stiffness and dysmenorrhea was analyzed by performing elastography on premenopausal women diagnosed with adenomyosis. Expression levels
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Longitudinal changes of oxidative stress and PON1 lactonase activity and status in older pregnant women undergoing assisted reproductive technology: a prospective nested case-control study Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-26 Chenyu Jiang, Meng Chen, Yujie Wu, Huai Bai, Xinghui Liu, Ping Fan
Childbearing in women with advanced maternal age (AMA) has increased the need for artificial reproductive technology (ART). ART and oxidative stress are associated with many pregnancy complications. Paraoxonase (PON) 1 is one of the key components responsible for antioxidative activity in high-density lipoprotein (HDL). This study aimed to investigate the longitudinal changes of oxidative stress and
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Circulating acyl-CoA-binding protein/diazepam-binding inhibitor in gestational diabetes mellitus Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-23 Robin Schürfeld, Ekaterine Baratashvili, Marleen Würfel, Matthias Blüher, Michael Stumvoll, Anke Tönjes, Thomas Ebert
Acyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has recently been characterized as an endocrine factor affecting energy balance and lipid metabolism. However, regulation of ACBP in women with gestational diabetes mellitus (GDM) during pregnancy, as well as postpartum, has not been investigated, so far. ACBP was quantified in 74 women with GDM and 74 healthy, gestational age-matched, pregnant
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Association between serum AMH levels and IVF/ICSI outcomes in patients with polycystic ovary syndrome: a systematic review and meta-analysis Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-23 Tianyi Yuwen, Ziyi Yang, Guhao Cai, Gengchen Feng, Qichen Liu, Huijia Fu
Anti-Müllerian hormone (AMH) levels are increased in polycystic ovary syndrome (PCOS) patients and are associated with PCOS severity. To evaluate the associations between serum AMH levels and in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) outcomes in patients with PCOS. PubMed, Embase, and the Cochrane Library were searched on 11 July 2022. Studies reporting the association between
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Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42 Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-23 David B. Seifer, Sarah F. Wang, David Frankfurter
To disaggregate the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) age category of “ > 42” and compare age-stratified cumulative live birth rates (CLBR) > 42 years old. Retrospective cohort study of autologous linked ART cycles. United States (US) National ART Database. Women > 42 years old without a history of prior ART cycles who underwent ART between 2014–2020
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Applications of laser technology in the manipulation of human spermatozoa Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-21 Yamei Xue, Yuping Xiong, Xiaohong Cheng, Kun Li
The application of laser technology in the field of assisted reproductive technology (ART) has experienced rapid growth over the past decades owing to revolutionary techniques such as intracytoplasmic sperm injection (ICSI), preimplantation genetic testing (PGT), and in vitro manipulation of gametes and embryos. For male gametes, in vitro manipulation techniques include spermatozoa selection, sorting
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Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia Reprod. Biol. Endocrinol. (IF 4.4) Pub Date : 2023-10-04 Jingzhe Song, Nan Zhu, Xinchen Pan, Lu Guo, Xiang Kong
Cathepsin C (Cat C) is involved in the inflammatory-immune system and can be degraded by cathepsin D (Cat D). Preeclampsia (PE) and the inflammation-immunity relationship is currently a hot research topic, but there are still few studies. The aim was to investigate the expression and significance of Cat C and D in the serum of nonpregnant women, patients in various stages of pregnancy and patients