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A paradigm shift in the management of patients with Parkinson's disease. Neurodegener. Dis. (IF 3.0) Pub Date : 2023-11-01 Konstantinos I Tsamis,Per Odin,Angelo Antonini,Heinz Reichmann,Spyridon Konitsiotis
BACKGROUND Technological evolution leads to the constant enhancement of monitoring systems, recording symptoms of diverse disorders. SUMMARY For Parkinson's disease, wearable devices empowered with machine learning analysis are the main modules for objective measurements. Software and hardware improvements have led to the development of reliable systems that can detect symptoms accurately and be implicated
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Verbal learning impairment in Parkinson's disease: role of the frontostriatal system in working and strategic memory. Neurodegener. Dis. (IF 3.0) Pub Date : 2023-09-27 Alessandro Cocuzza,Teresa Difonzo,Edoardo Nicolò Aiello,Luca Pietro Ernesto Sbrissa,Stefano Zago,Claudia Gendarini,Martina Andrea Sirtori,Barbara Poletti,Nicola Ticozzi,Giulia Franco,Alessio Di Fonzo,Giacomo Pietro Comi,Maria Cristina Saetti
BACKGROUND Learning is a long-term memory process, influenced by working memory control processes, including recognition of semantic properties of items by which subjects generate a semantic structure of engrams. OBJECTIVES The aim of the study is to investigate the verbal learning strategies of individuals with Parkinson's disease (PD). METHOD Thirty individuals with idiopathic PD and healthy control
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Lithium: An Old Drug for New Therapeutic Strategy for Alzheimer's Disease and Related Dementia. Neurodegener. Dis. (IF 3.0) Pub Date : 2023-09-04 Seong Sool Shim,Ken Berglund,Shan Ping Yu
BACKGROUND Although Alzheimer's disease (AD) is the most common form of dementia, the effective treatment of AD is not available currently. Multiple trials of drugs, which were developed based on the amyloid hypothesis of AD, have not been highly successful to improve cognitive and other symptoms in AD patients, suggesting that it is necessary to explore additional and alternative approaches for the
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Ecological Validity of the Montreal Cognitive Assessment in Non-Demented Parkinson's Disease Patients. Neurodegener. Dis. (IF 3.0) Pub Date : 2023-07-21 Edoardo Nicolò Aiello,Alfonsina D'Iorio,Federica Solca,Silvia Torre,Eleonora Colombo,Alessio Maranzano,Alberto De Lorenzo,Valerio Patisso,Mauro Treddenti,Claudia Morelli,Alberto Doretti,Luca Maderna,Federico Verde,Roberta Ferrucci,Sergio Barbieri,Fabiana Ruggiero,Alberto Priori,Vincenzo Silani,Nicola Ticozzi,Gabriella Santangelo,Andrea Ciammola,Barbara Poletti
BACKGROUND The ecological validity of performance-based cognitive screeners needs to be tested in order for them to be fully recommended for use within clinical practice and research. OBJECTIVES The objective of this study was to examine, within an Italian cohort of non-demented Parkinson's disease (PD) patients, the ecological validity of the Montreal Cognitive Assessment (MoCA) by assessing its association
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CSF Aβ40 Levels Do Not Correlate with the Clinical Manifestations of Alzheimer's Disease. Neurodegener. Dis. (IF 3.0) Pub Date : 2023-05-15 Jesús Garcia Castro,Helena Méndez Del Sol,Olaia Rodríguez Fraga,María Hernández Barral,Soledad Serrano López,Ana Frank García,Ángel Martín Montes
INTRODUCTION Cerebrospinal fluid (CSF) biomarker quantification provides physicians with a reliable diagnosis of Alzheimer's disease (AD). However, the relationship between their concentration and disease course has not been clearly elucidated. This work aimed to investigate the clinical and prognostic significance of Aβ40 CSF levels. METHODS A retrospective cohort of 76 patients diagnosed with AD
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The two-way route between delirium disorder and dementia: insights from Covid-19 Neurodegener. Dis. (IF 3.0) Pub Date : 2023-04-13 Giulia Bommarito, Valentina Garibotto, Giovanni B Frisoni, Frédéric Assal, Patrice H Lalive, Gilles Allali
Background. Delirium disorder is a frequent neurological complication of SARS-CoV-2 infection and associated with an increased disease severity and mortality. Cognitive impairment is a major risk factor for developing delirium disorder during Covid-19, which, in turn, increases the risk of subsequent neurological complications and cognitive decline. Summary. The bidirectional connection between delirium
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Clinical manifestations associated with the domain-containing protein 2 (DDHD2) gene mutation in an Iranian family with Spastic Paraplegia 54 Neurodegener. Dis. (IF 3.0) Pub Date : 2023-03-28 Abolfazl Yari, Shokoofeh Etesam, Shannaz Zarifi, Sepideh Parvizpour, Ebrahim Miri-Moghaddam
Introduction: Spastic paraplegia type 54 (SPG54) is an autosomal recessive disorder, caused by bi-allelic mutations in the DDHD2 gene. Worldwide, over 24 SPG54 families and 24 pathogenic variants have been reported. Our study aimed to describe the clinical and molecular findings of a pediatric patient from a consanguineous Iranian family with significant motor development delay, walking problems, paraplegia
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Age of onset and length of survival of Queensland patients with amyotrophic lateral sclerosis: with details of subjects with early onset and subjects with long survival. Neurodegener. Dis. (IF 3.0) Pub Date : 2022-12-30 Robert J. Nona, Zhouwei Xu, Gail A. Robinson, Robert D. Henderson, Pamela A. McCombe
Introduction: To document the characteristics of ALS patients in Queensland, to examine factors influencing age of onset and survival, and to study those with early onset (<45 years) disease and those with long (> 5 years) survival. Methods: We studied subjects seen at the ALS Clinic at the Royal Brisbane Women’s Hospital. We recorded sex, age of onset, region of onset, length of survival, presence
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The Immunomodulatory Potential Role of Mesenchymal Stem Cells in Diseases of the Central Nervous System. Neurodegener. Dis. (IF 3.0) Pub Date : 2022-11-17 Rodrigo de Andrade Rufino,Laís da Silva Pereira-Rufino,Thays Cristina Silva Vissoto,Irina Kerkis,Adriana da Costa Neves,Marcelo Cavenaghi Pereira da Silva
INTRODUCTION Several studies indicate the role of mesenchymal stem cells (MSCs) as an important tool in regenerative medicine associated with injuries that affect the central nervous system (CNS). The MSCs have the capacity to differentiate into cells of the embryonal tissue, such as the mesoderm. So, these cells can be found in a variety of tissues. Also, the MSCs can release immunomodulatory and
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Natural age-related slow-wave sleep alterations onset prematurely in the Tg2576 mouse model of Alzheimer’s disease Neurodegener. Dis. (IF 3.0) Pub Date : 2022-10-27 Sedef Kollarik, Inês Dias, Carlos G. Moreira, Dorita Bimbiryte, Djordje Miladinovic, Joachim M. Buhmann, Christian R. Baumann, Daniela Noain
Introduction: Sleep insufficiency or decreased quality have been associated with Alzheimer’s disease (AD) already in its preclinical stages. Whether such traits are also present in rodent models of the disease has been poorly addressed, somewhat disabling the preclinical exploration of sleep-based therapeutic interventions for AD. Methods: We investigated age-dependent sleep-wake phenotype of a widely
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4-Phthalimidobenzenesulfonamide Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: DFTs, 3D-QSAR, ADMET, and Molecular Dynamic Simulation Neurodegener. Dis. (IF 3.0) Pub Date : 2022-10-26 Syeda Abida Ejaz, Ammara Fayyaz, Hafiz Mohammad Kashif Mahmood, Mubashir Aziz, Syeda Rabia Ejaz, Afrah F. Alkhuriji, Wafa Abdullah I. Al-Megrin, Abdullahi Tunde Aborode, Gaber El-Saber Batiha
Introduction: Alzheimer's disease (AD) is a form of dementia which affects majority of the people. It is characterized by memory loss and other cognitive functions disabilities and is one of the most challenging neurodegenerative disorders to treat, because of its progressive nature. The disease affects millions of people all around the world, and the number of those affected is expanding every day
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CSF Aβ40 and P-tau181 might differentiate atypical from typical AD phenotypes: preliminary evidence Neurodegener. Dis. (IF 3.0) Pub Date : 2022-09-15 Federico Verde, Edoardo Nicolò Aiello, Eleonora Giacopuzzi Giacopuzzi Grigoli, Ilaria Milone, Antonella Dubini, Antonia Ratti, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani
Objectives. This study aimed at testing whether CSF levels of amyloid β42 (Aβ42), Aβ40, total tau and phosphorylated tau (P-tau181) individually contribute to the identification of atypical phenotypes among a retrospective cohort of probable AD patients diagnosed by means of the ratio between Aβ42 and Aβ40 (Aβ42/40). Methods. The retrospective study cohort comprised 50 probable AD patients diagnosed
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Frontostriatal circuits alterations associated with cognitive flexibility deterioration in Huntington's disease Neurodegener. Dis. (IF 3.0) Pub Date : 2022-09-06 Gustavo Padron-Rivera, Angel Omar Romero-Molina, Rosalinda Diaz, Israel Vaca-Palomares, Adriana Ochoa-Morales, César Romero-Rebollar, Amanda Chirino-Pérez, Juan Fernandez-Ruiz
Background: Recent resting-state functional magnetic resonance imaging studies have reported abnormal functional connectivity (FC) in the prefrontal cortex (PFC)-striatum circuit in patients with premanifest Huntington's disease (HD). However, there is a lack of evidence showing persistence of abnormal frontostriatal FC and its relation to cognitive flexibility performance in patients with clinically
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Association between Gut Microbiota with Mild Cognitive Impairment and Alzheimer’s Disease in a Thai Population Neurodegener. Dis. (IF 3.0) Pub Date : 2022-09-07 Pagakrong Wanapaisan, Mallika Chuansangeam, Saifon Nopnipa, Rubwad Mathuranyanon, Nutthawan Nonthabenjawan, Chanon Ngamsombat, Tanyaluck Thientunyakit, Weerasak Muangpaisan
Background: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are common in older adults. Much recent work has implicated the connection between the gut and the brain via bidirectional communication of the gastrointestinal tract and the central nervous system through biochemical signaling. Altered gut microbiota composition has shown controversial results based on geographic location, age
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Hippocampal Functional Connectivity in Parkinson’s Disease Neurodegener. Dis. (IF 3.0) Pub Date : 2022-08-09 Landis E. Llewelyn, Myriam Kornisch, Hyejin Park, Toshikazu Ikuta
Background: While the hippocampus is not part of the nigrostriatal dopaminergic pathway, influence of Parkinson’s Disease (PD) to the hippocampus has been consistently implicated. However, it is not clear how the hippocampal changes contribute to the pathology of PD. Objectives: We aimed to elucidate the physiological changes of the hippocampus in its orchestration with the rest of the brain. Methods:
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Synaptic neurofilaments and GluN1-NfL interaction in experimental models of α-synucleinopathies Neurodegener. Dis. (IF 3.0) Pub Date : 2022-08-08 Alberto Imarisio, Elena Ferrari, Andrea Pilotto, Monica Di Luca, Alessandro Padovani, Fabrizio Gardoni
Introduction: despite neurofilaments are mainly expressed in large caliber myelinated axons, recent evidence supports the existence of a specific synaptic pool, where neurofilament light chain (NfL) has been proposed to stabilize NMDAR at post-synaptic membrane through a direct interaction with the GluN1 subunit. Here, we assessed the expression and synaptic abundance of neurofilaments and their interaction
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Clinical and molecular findings of intermediate allele carriers in the HTT gene from the Mexican Mestizo population Neurodegener. Dis. (IF 3.0) Pub Date : 2022-08-04 Miguel Ángel Ramírez-García, David José Dávila-Ortiz de Montellano, Leticia Martínez-Ruano, Adriana Ochoa-Morales, Sandra Romero-Hidalgo, Juan Carlos Zenteno, Petra Yescas-Gómez
Introduction: There are reports of different clinical statuses in carriers of intermediate alleles (IAs) of CAG trinucleotide repeats in the HTT gene, from individuals affected by a clinical picture indistinguishable from Huntington's disease (HD) to those without manifestations. Therefore, the possible clinical significance of these alleles has been widely debated. Objectives: To describe general
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Acknowledgement to Reviewers Neurodegener. Dis. (IF 3.0) Pub Date : 2022-07-18
Neurodegener Dis 2021;21:150
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Contents Vol. 21, 2021 Neurodegener. Dis. (IF 3.0) Pub Date : 2022-07-18
Neurodegener Dis 2021;21:I–VI
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Early Autonomic Symptoms Predict Functional Decline in Parkinson’s Disease Independent of Dopaminergic Therapy Neurodegener. Dis. (IF 3.0) Pub Date : 2022-07-04 Cameron Miller-Patterson, Jesse Y. Hsu, Lana M. Chahine
Introduction: Parkinson’s disease (PD) has variable progression; identifying determinants of functional decline in PD is needed for accurate prognostication. Autonomic symptoms can result from dopaminergic therapy, but may also independently predict functional decline. Methods: The sample included individuals with newly-diagnosed PD in Parkinson’s Progression Markers Initiative. Autonomic symptoms
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Heart Rate Variability in Huntington Disease. A Long Term Longitudinal Study Neurodegener. Dis. (IF 3.0) Pub Date : 2022-06-29 Jan Kobal, Ksenija Cankar, Ziva Melik
Introduction: The aim of the study was to follow tonic and phasic autonomic nervous activity in Huntington disease (HD) mutation carriers and patients. Methods: Evaluation of motor functions and total functional capacity was performed in 30 HD mutation carriers or patients at the beginning and in 22 subjects after 8-10 years. Continuous arterial blood pressure, heart rate (HR), ECG at rest were measured
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Juvenile-Onset Kufs Disease in a Chinese Consanguineous Family due to CLN6 Mutation Neurodegener. Dis. (IF 3.0) Pub Date : 2022-05-24 Weimin Jia, Yalin Luo, Jiuxiang Wang, Yue Yang, Wenming Yang, Xianqin Zhang
Objective: To identify the genetic cause of two cases of Kufs disease in the same family. The two affected individuals exhibited different levels of severity under magnetic resonance imaging (MRI). Methods: Whole-exome sequencing was performed on affected individuals, and the candidate gene was confirmed by Sanger sequencing. Western blot analysis was used to evaluate the level of expression of CLN6
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Diagnostic accuracy of noun- and verb-naming tasks in detecting cognitive impairment in Parkinson’s disease Neurodegener. Dis. (IF 3.0) Pub Date : 2022-05-23 Edoardo Nicolò Aiello, Margherita Grosso, Claudia Caracciolo, Adele Andriulo, Simona Buscone, Monica Ottobrini, Claudio Luzzatti
Background. In Parkinson’s disease (PD), verb-naming tasks have been proposed as superior to noun-naming ones in detecting language deficits, although such an hypothesis is not supported at a statistical level. Objectives. Providing diagnostic accuracy evidence for a verb- and noun-naming task in detecting cognitive impairment in PD patients. Method. Thirty-three consecutive PD patients were subdivided
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Distribution Changes of Neural Precursor Cells in the Brain Stem of Tg(SOD1*G93A)1Gur Mice Neurodegener. Dis. (IF 3.0) Pub Date : 2022-05-18 Xiaoping Shen, Chunyan Tang, Qin Kang, Yu Zhu, Shengyuan Xu, Jianxiang Jiang, Renshi Xu
Objectives: The alteration of vimentin-containing cells (VCCs) proliferation, differentiation and migration in the brain stem of amyotrophic lateral sclerosis (ALS)-like transgenic mice (Tg(SOD1*G93A)1Gur mice) (TG mice) and wild-type mice (WT mice) at the different disease stages of TG mice were studied in this study. The aim of this study was to investigate the change features of proliferation, differentiation
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Plasma Cystatin C correlates with plasma NfL levels and predicts disease progression in Parkinson’s disease Neurodegener. Dis. (IF 3.0) Pub Date : 2022-03-14 Alberto Imarisio, Andrea Pilotto, Emirena Garrafa, Francesca Conforti, Stefano Masciocchi, Rosanna Turrone, Stefano Gipponi, Elisabetta Cottini, Maria Cristina Rizzetti, Vanessa Porrini, Cristina Gussago, Marina Pizzi, Fiorella Guadagni, Henrik Zetterberg, Nicholas J. Ashton, Abdul Hye, Alessandro Padovani
Introduction: Previous studies reported increased plasma levels of Cystatin C (Cys-C) in Parkinson’s disease (PD) and claimed for a possible association with disease severity and progression. The aim of this study was to evaluate plasma Cys-C in PD and healthy controls (HC) and test its association with markers of peripheral inflammation, neurodegeneration and clinical progression in a longitudinal
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Neuroprotective and therapeutic effects of Tocovid and Twendee-X on Aβ oligomers-induced damage in the SH-SY5Y cell line Neurodegener. Dis. (IF 3.0) Pub Date : 2022-03-10 Xiao Hu, Toru Yamashita, Haibo Yu, Zhihong Bian, Xinran Hu, Tian Feng, Koh Tadokoro, Ryuta Morihara, Koji Abe
Background: Alzheimer’s disease (AD) is the most frequent cause of dementia among the elderly. The accumulation of amyloid beta (Aβ) and its downstream pathological events such as oxidative stress play central roles in AD. Recent studies revealed that Aβ oligomers (AβOs) induced strong neurotoxicity in SH-SY5Y cells via the induction of oxidative stress. Objective: In the present study, we investigated
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Inflammatory cytokine levels in patients with sporadic amyotrophic lateral sclerosis Neurodegener. Dis. (IF 3.0) Pub Date : 2022-02-04 Qionghua Sun, Yunyun Huo, Jiongming Bai, Haoran Wang, Hongfen Wang, Fei Yang, Fang Cui, Han Song, Xusheng Huang
Objectives In the present study, inflammatory factors, including interleukin (IL) and tumor necrosis factor-α (TNF-α) in the peripheral blood of patients with sporadic amyotrophic lateral sclerosis (sALS) were evaluated, and the issue of whether these variables were associated with the progression and severity of the disease examined. Methods Data on inflammatory factors, including IL-1, IL-2, IL-6
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Sexuality and neurodegenerative disease: An unmet challenge for patients, care-givers and treatment. Neurodegener. Dis. (IF 3.0) Pub Date : 2022-01-18 Mohamed Eshmawey
Background: Many factors affect sexuality in the elderly such as dementia which is a common cause of inappropriate sexual behaviors. These behavioral disturbances are distressing, disruptive and impair the care of the patient. Summery: The onset of dementia does not erase sexuality. Sexual expression can be an important aspect of wellbeing for older adults with dementia. This study gives a general
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Homoharringtonine inhibits Alzheimer’s disease progression by reducing neuroinflammation via STAT3 signaling in APP/PS1 mice Neurodegener. Dis. (IF 3.0) Pub Date : 2021-11-22 Xinyuan Jiang, Qingdong Wu, Cuicui Zhang, Maobo Wang
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Acknowledgement to Reviewers Neurodegener. Dis. (IF 3.0) Pub Date : 2021-11-11
Neurodegener Dis 2020;20:217
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Contents Vol. 20, 2020 Neurodegener. Dis. (IF 3.0) Pub Date : 2021-11-11
Neurodegener Dis 2020;20:I–VI
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Increased intake of fast acting carbohydrates in patients with Parkinson’s Disease Neurodegener. Dis. (IF 3.0) Pub Date : 2021-11-09 Eva Schäffer, Alina Schermann, Florian Zirbs, Daniela Berg
Background: Patients with Parkinson’s Disease (PD) regularly report an increased desire for food or beverages with high sugar content. Objective: To verify the hypothesis of an increase intake of fast-acting carbohydrates in PD patients. Methods: This study investigated the consumption of high sugar-content food products in 221 PD patients compared with 184 healthy controls using a self-administered
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Heart Rate Variability during wake and sleep in Huntington’s Disease patients. An observational, cross-sectional, cohort study. Neurodegener. Dis. (IF 3.0) Pub Date : 2021-11-08 Jessica Marotta, Carla Piano, VALERIO BRUNETTI, Danilo Genovese, Anna Rita Bentivoglio, Paolo Calabresi, Pietro Cortelli, Giacomo Della Marca
Introduction Autonomic dysfunction has been reported as one of non-motor manifestations of both pre-symptomatic and manifest Huntington’s Disease (HD). The aim of our study was to evaluate heart rate variability (HRV) during wake and sleep in a cohort of patients with manifest HD. Methods Thirty consecutive patients with manifest HD were enrolled, 14 men and 16 women, mean age 57.3±12.2 years. All
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Review of available data for the efficacy and effectiveness of nabiximols oromucosal spray (Sativex) in multiple sclerosis patients with moderate to severe spasticity Neurodegener. Dis. (IF 3.0) Pub Date : 2021-11-03 Antonella Conte, Carlos Vila Silván
Background: Sativex (USAN: nabiximols) oromucosal spray is indicated for treatment of multiple sclerosis (MS) patients with moderate to severe spasticity and inadequate response to other antispasticity medications who demonstrate clinically significant improvement during an initial trial of therapy. This narrative review investigated the efficacy and effectiveness of nabiximols oromucosal spray for
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Tit for tat: costly punishment in manifest Huntington’s disease Neurodegener. Dis. (IF 3.0) Pub Date : 2021-10-27 Beatrice Heim, Marina Peball, Carsten Saft, Sarah Maria von Hein, Johanna Maria Piater, Philipp Ellmerer, Klaus Seppi, Atbin Djamshidian-Tehrani
Objective: We aimed to investigate costly punishment in patients with HD. Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease with motor, cognitive, and psychiatric symptoms. As neuropsychiatric abnormalities often precede motor symptoms, we wanted to assess whether costly punishment is part of the neuropsychological profile of patients with HD. Methods: A total
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Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid in Parkinson’s disease and atypical parkinsonian syndromes Neurodegener. Dis. (IF 3.0) Pub Date : 2021-10-25 Michaela Kaiserova, Monika Chudackova, Hana Prikrylova Vranova, Katerina Mensikova, Anetta Kastelikova, David Stejskal, Petr Kanovský
Background: Various cerebrospinal fluid (CSF) biomarkers are studied in Parkinson’s disease (PD) and atypical parkinsonian syndromes (APS). Several studies found reduced 5-hydroxyindoleacetic acid (5-HIAA), the main serotonin metabolite, in PD. There is little evidence regarding its levels in APS. Methods: We measured 5-HIAA in the CSF of 90 PD patients, 16 MSA patients, 26 progressive supranuclear
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Cancer in Parkinson Disease: an approximation to the main risk factors Neurodegener. Dis. (IF 3.0) Pub Date : 2021-10-21 Irene Rosas, Germán Morís, Eliecer Coto, Marta Blázquez, Esther Suárez, Ciara García-Fernández, Pablo Siso, Carmen Martínez, Sergio Pérez-Oliveira, Victoria Álvarez, Manuel Menéndez-González
Abstract Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a a decreased incidence of most cancer types in Parkinson's disease (PD) patients and some PD genes are involved in cancer networks. Objective : The aim of this study is to assess the influence of several factors in the risk of cancer in a cohort
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Association between excessive daytime sleepiness and the cholinergic ascending reticular system in Parkinson’s disease Neurodegener. Dis. (IF 3.0) Pub Date : 2021-09-24 Mutsumi Iijima, Mikio Osawa, Sayuri Yasuda, Kazuo Kitagawa
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Characteristics of late-onset amyotrophic lateral sclerosis in a Chinese cohort Neurodegener. Dis. (IF 3.0) Pub Date : 2021-08-20 Qionghua Sun, Yunyun Huo, Jiongming Bai, Haoran Wang, Fang Cui, Hongfen Wang, Fei Yang, Xusheng Huang
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The impact of the COVID-19 pandemic on dementia risk: Potential pathways to cognitive decline Neurodegener. Dis. (IF 3.0) Pub Date : 2021-07-28 Jeffrey D Pyne, Adam M Brickman
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The effects of 8-week combined exercise training on inflammatory markers in women with multiple sclerosis Neurodegener. Dis. (IF 3.0) Pub Date : 2021-07-20 Fahime Tadayon Zadeh, Hamid Amini, Saeed Habibi, Valiallah Shahedi, Amin Isanejad, Mohsen Akbarpour
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Computerized Simple Reaction Time and Balance in Nondemented Parkinson’s Patients Neurodegener. Dis. (IF 3.0) Pub Date : 2021-07-16 Aida Arroyo-Ferrer, Jorge Andreo, José A. Periáñez, Marcos Ríos-Lago, Genny Lubrini, Jaime Herreros-Rodríguez, Juan García-Caldentey, Juan Pablo Romero
Background: Parkinson’s disease (PD) patients are known to suffer from subtle cognitive and balance deficits from the early stages although they usually manifest in advanced stages. Postural instability (PI) has been correlated with slower information processing speed. Simple reaction time (SRT) tasks can be used to measure the speed of information processing. The main objective of this study was to
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Involvement of the Auditory Pathway in Spinocerebellar Ataxia Type 7 Neurodegener. Dis. (IF 3.0) Pub Date : 2021-07-09 Laura E. Ramos-Languren, Roberto Rodríguez-Labrada, Jonathan J. Magaña, Nalia Canales-Ochoa, Yanetza González-Zaldivar, Luis Velázquez-Pérez, Rigoberto González-Piña
Background: Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant disorder caused by a mutation in the ATXN7 gene. The involvement of the brainstem auditory pathway in pathogenesis of this disease has not been systematically assessed. Aim: To determine involvement of the brainstem auditory pathway in SCA7 patients and its relationship to clinical features of the disease. Methods: In this case-control
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Extending the spectrum of non-motor symptoms with olfaction in pre-motor Huntington’s disease – a pilot study Neurodegener. Dis. (IF 3.0) Pub Date : 2021-07-09 Beatrice Heim, Dora Valent, Federico Carbone, Sabine Spielberger, Florian Krismer, Atbin Djamshidian-Tehrani, Klaus Seppi
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Elevated levels of homocysteinesulfinic acid in the plasma of patients with amyotrophic lateral sclerosis: a potential source of excitotoxicity? Neurodegener. Dis. (IF 3.0) Pub Date : 2021-06-21 Aven Lee, Buddhika Jayakody Arachchige, Robert Henderson, James Aylward, Pamela Ann McCombe
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Prevalence of gastrointestinal symptoms, severity of dysphagia, and their correlation with severity of amyotrophic lateral sclerosis in a Mexican cohort Neurodegener. Dis. (IF 3.0) Pub Date : 2021-06-17 Carolina Parra-Cantu, Arnulfo Zaldivar-Ruenes, Manuel Martinez-Vazquez, Hector R. Martinez
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Cerebrospinal Fluid Alzheimer’s Biomarkers and Neurofilament Light Profile of Idiopathic Normal Pressure Hydrocephalus in China: A PUMCH Cohort Study Neurodegener. Dis. (IF 3.0) Pub Date : 2021-06-02 Chenhui Mao, Longze Sha, Caiyan Liu, Shanshan Chu, Jie Li, Xinying Huang, Dan Lei, Jie Wang, Liling Dong, Qi Xu, Bin Peng, Li-Ying Cui, Jing Gao
Introduction: Idiopathic normal pressure hydrocephalus (iNPH) is one of the potentially reversible dementias. Early and accurate diagnosis is important for patients’ prognosis. Emerging evidence shows fluid biomarkers are useful in diagnosis and pathophysiological research of iNPH. Methods: Probable iNPH and Alzheimer’s disease (AD) patients were recruited. Clinical diagnosis was performed according
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Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of Tauopathy Neurodegener. Dis. (IF 3.0) Pub Date : 2021-05-11 Aidana Massalimova, Ruiqing Ni, Roger M. Nitsch, Marco Reisert, Dominik von Elverfeldt, Jan Klohs
Introduction: Increased expression of hyperphosphorylated tau and the formation of neurofibrillary tangles are associated with neuronal loss and white matter damage. Using high-resolution ex vivo diffusion tensor imaging (DTI), we investigated microstructural changes in the white and grey matter in the P301L mouse model of human tauopathy at 8.5 months of age. For unbiased computational analysis, we
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The Prevalence and Management of Saliva Problems in Motor Neuron Disease: A 4-Year Analysis of the Scottish Motor Neuron Disease Register Neurodegener. Dis. (IF 3.0) Pub Date : 2021-04-26 Iona Pearson, Stella A. Glasmacher, Judith Newton, Emily Beswick, Arpan R. Mehta, Richard Davenport, Siddharthan Chandran, Suvankar Pal, CARE-MND consortium
Introduction: Saliva problems are common and distressing for people with motor neuron disease (pwMND). Despite clinical guidelines for assessment and treatment, management of saliva problems has received little research attention. Objective: We aimed to investigate the prevalence of saliva problems in pwMND, their association with clinical factors, and their management practice using a highly curated
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Association of Progressive Supranuclear Palsy Rating Scale with Progressive Supranuclear Palsy Quality of Life Scale Neurodegener. Dis. (IF 3.0) Pub Date : 2021-03-31 Alexander Pantelyat, Lenora Higginbotham, Liana Rosenthal, Diane Lanham, Vanessa Nesspor, Mina AlSalihi, Jee Bang, Jiangxia Wang, Marilyn Albert
Introduction: There is growing interest in using patient-reported outcomes as end points in clinical trials, such as the progressive supranuclear palsy quality of life (PSP-QoL) scale. However, this tool has not been widely validated and its correlation with validated motor scales has not been explored. To evaluate the potential utility of using PSP-QoL as an outcome, it is important to examine its
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Brain Atrophy Subtypes and the ATN Classification Scheme in Alzheimer’s Disease Neurodegener. Dis. (IF 3.0) Pub Date : 2021-03-31 Nira Cedres, Urban Ekman, Konstantinos Poulakis, Sara Shams, Lena Cavallin, Sebastian Muehlboeck, Tobias Granberg, Lars-Olof Wahlund, Daniel Ferreira, Eric Westman, Alzheimer’s Disease Neuroimaging Initiative
Introduction: We investigated the association between atrophy subtypes of Alzheimer’s disease (AD), the ATN classification scheme, and key demographic and clinical factors in 2 cohorts with different source characteristics (a highly selective research-oriented cohort, the Alzheimer’s Disease Neuroimaging Initiative [ADNI]; and a naturalistic heterogeneous clinically oriented cohort, Karolinska Imaging
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The Added Value of Inflow-Based Vascular-Space-Occupancy and Diffusion-Weighted Imaging in Preoperative Grading of Gliomas Neurodegener. Dis. (IF 3.0) Pub Date : 2021-03-18 Haimei Cao, Xiang Xiao, Jun Hua, Guanglong Huang, Wenle He, Jie Qin, Yuankui Wu, Xiaodan Li
Objectives: The present study aimed to study whether combined inflow-based vascular-space-occupancy (iVASO) MR imaging (MRI) and diffusion-weighted imaging (DWI) improve the diagnostic accuracy in the preoperative grading of gliomas. Methods: Fifty-one patients with histopathologically confirmed diffuse gliomas underwent preoperative structural MRI, iVASO, and DWI. We performed 2 qualitative consensus
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Sleep-Disordered Breathing in Patients with Motor Neurone Disease: One Size Does Not Fit all Neurodegener. Dis. (IF 3.0) Pub Date : 2021-03-18 Vinod Aiyappan, Peter Catcheside, Nick Antic, Graham Keighley-James, Jeremy Mercer, R. Doug McEvoy
Introduction: Sleep-disordered breathing (SDB) in patients with motor neurone disease (MND) is normally attributed to hypoventilation due to muscle weakness. However, we have observed different patterns of SDB among MND patients referred for non-invasive ventilation, which do not appear to be explained by respiratory muscle weakness alone. Aim: The aim of this study was to examine the characteristics
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Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review Neurodegener. Dis. (IF 3.0) Pub Date : 2021-02-18 Momin Hua, Jia Min
Background: Currently, the number of individuals who undergo surgery is greatly increased. As a consequence, postoperative cognitive dysfunction (POCD) has gradually gained more attention. Summary: POCD is a perioperative complication requiring sensitive preoperative and postoperative neuropsychiatric tests, and its incidence in both cardiac and noncardiac surgery is high, especially in elderly individuals
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Publisher's Note. Neurodegener. Dis. (IF 3.0) Pub Date : 2020-07-16 P.G. Unschuld, Roger M. Nitsch, Christoph Hock, Paul G. Unschuld, Paul L. Herrling, Vanda Pogacic, Iwatsubo Takeshi, Rudolf Glockshuber, Avraham Fisher, C. Van Broeckhoven, Nick C. Fox, Richard S.J. Frackowiak, A. Villringer, C.L. Masters, Michel Goedert, Bernardino Ghetti, John H. Growdon, Steven T. DeKosky, Alexis Brice, Masatoshi Takeda, Takeshi Iwatsubo, Edward H. Koo, Lars Lannfelt, Konrad Beyreuther
Neurodegener Dis
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Acknowledgement to Reviewers. Neurodegener. Dis. (IF 3.0) Pub Date : 2020-06-17
Neurodegener Dis 2019;19:244
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Contents Vol.19, 2019 Neurodegener. Dis. (IF 3.0) Pub Date : 2020-06-17
Neurodegener Dis 2019;19:I–VI
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Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease. Neurodegener. Dis. (IF 3.0) Pub Date : 2020-05-26 Ji-Hyun Choi,Jee-Young Lee,Beomseok Jeon,Seong-Beom Koh,Won Tae Yoon,Ho-Won Lee,Oh Dae Kwon,Jae Woo Kim,Jong-Min Kim,Hyeo-Il Ma,Hee Tae Kim,Jong Sam Baik,Jin Whan Cho
INTRODUCTION Impulse control disorder (ICD) in Parkinson's disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD. OBJECTIVE This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD. METHODS We conducted a case-control study using a database of a multicenter
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CREB Protects against Temporal Lobe Epilepsy Associated with Cognitive Impairment by Controlling Oxidative Neuronal Damage. Neurodegener. Dis. (IF 3.0) Pub Date : 2020-05-15 Jihong Xing,Dongfeng Han,Dahai Xu,Xingliang Li,Lichao Sun
BACKGROUND Cognitive dysfunction as a common comorbidity of epilepsy often manifests as learning and memory impairments in patients with temporal lobe epilepsy (TLE). The pathogenetic molecular mechanisms underlying epilepsy-associated cognitive dysfunction are incompletely understood. We investigated the role of cAMP response element binding protein (CREB) and its downstream signaling pathways in
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Brain Structural Plasticity Associated with Maternal Caregiving in Mothers: A Voxel- and Surface-Based Morphometry Study. Neurodegener. Dis. (IF 3.0) Pub Date : 2020-05-12 Kaihua Zhang,Mengxing Wang,Jilei Zhang,Xiaoxia Du,Zhong Chen
BACKGROUND Pregnancy constitutes a significant period in the lives of women, after which they often experience numerous crucial physiological and psychological changes. Functional neuroimaging studies have shown longitudinal changes in functional brain activity in mothers responding to infant-related stimuli. However, the structural changes that occur in the brains of mothers after delivery remain