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Altered Allocation of Vertical Attention in Individuals With Autism Spectrum Disorder Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-04-17 Alisha J. Steigerwald, Bradley J. Ferguson, Nanan Nuraini, Joseph C. Barnett, Nicole Takahashi, Rachel Zamzow, Kenneth M. Heilman, David Q. Beversdorf
Background: Typical adults most frequently orient their attention to other people’s eyes, whereas individuals with autism spectrum disorder (ASD) orient their attention to other people’s mouths. Typical adults also reveal visuospatial biases on tasks such as vertical and horizontal line bisections. Therefore, the difference in face viewing might be related to a more general group difference in the
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Acute Mania and Psychosis in the Context of Primary Adrenal Insufficiency: A Systematic Review of the Literature Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-04-06 Andrew Ovakimyan, Neal A. Patel, Nolan J. Brown, Taylor Reardon, Gianna Fote, Julian Gendreau
Background: Given the sparse nature of acute mania or psychosis in primary adrenal insufficiency (PAI), physicians may not be aware of the association of these two entities. Objective: To conduct a systematic review of the literature for the purpose of identifying all studies reporting mania and/or psychosis in individuals with PAI. Method: We conducted a systematic review according to PRISMA (Preferred
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The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-04-06 Hella Thielen, Nora Tuts, Christophe Lafosse, Céline Raymond Gillebert
Background: Although subjective sensory hypersensitivity is prevalent after stroke, it is rarely recognized by health care providers, and its neural mechanisms are largely unknown. Objective: To investigate the neuroanatomy of poststroke subjective sensory hypersensitivity as well as the sensory modalities in which subjective sensory hypersensitivity can occur by conducting both a systematic literature
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A Selective Hand Posture Apraxia in an Individual With Posterior Cortical Atrophy and Probable Corticobasal Syndrome Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-27 Tomohiro Omori, Michitaka Funayama, Sachiko Anamizu, Mei Ishikawa, Richi Niida, Hajime Tabuchi
A selective impairment for making hand postures that are required to use specific tools has rarely been reported in individuals with acquired brain injury, and such an impairment has not been documented at all in individuals with degenerative disorders. We describe an individual with posterior cortical atrophy and probable corticobasal syndrome who was unable to use tools because of an inability to
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Differences in Implicit Attitudes in West and East Germans as Measured by the Go/NoGo Association Task and Event-related EEG Potentials Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-27 Tobias A. Wagner-Altendorf, Arie H. van der Lugt, Anna Kroeber, Anna Cirkel, Marcus Heldmann, Thomas F. Münte
Background and Objective: Implicit social cognition refers to attitudes and stereotypes that may reside outside conscious awareness and control but that still affect human behavior. In particular, the implicit favoritism of an ingroup, to which an individual belongs, as opposed to an outgroup, to which the individual does not belong, characterized as ingroup bias, is of interest and investigated here
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Memory and Consciousness—Usually in Tandem but Sometimes Apart Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-23 Christopher R. Madan
Episodic memory, the ability to remember specific events from one’s personal past, has been the subject of research for several decades, with a particular emphasis on its relationship with consciousness. In the December 2022 issue of Cognitive and Behavioral Neurology, Budson, Richman, and Kensinger shed new light on this complex topic with a comprehensive exploration of consciousness. In this commentary
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Pilot Study of the Effects of Paced Breathing on Measures of Convergent and Divergent Thinking Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 McKenzie B. Wallace, Amy N. Costa, Bradley J. Ferguson, Megan A. Carey, Chloe Rzeppa, Briana M. Kille, David R. Drysdale, Briann E. Sutton, Brianne H. Shuler, Ryan P. Johnson, Elizabeth P. Kwenda, Jamie Hadley, Whitney Snyders, David Q. Beversdorf
Background: The ability of the autonomic nervous system’s stress response to impair aspects of cognitive flexibility is known. However, the ability to modulate the sympathetic response and improve these cognitive impairments via nonpharmacological intervention, such as paced breathing (PB), requires further investigation. Objective: To better elucidate the effects of PB on cognition. Method: We
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Occurrence and Severity of Suicidal Ideation in Adults With Neurofibromatosis Participating in a Mind–Body RCT Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Ethan G. Lester, Katherine E. Wang, Jaishri O. Blakeley, Ana-Maria Vranceanu
Background: Emotional distress can lead to suicidal ideation and potentially suicide completion, yet there is very little literature on suicidal ideation in individuals with a diagnosis of neurofibromatosis (NF; NF1, NF2, and schwannomatosis). Objective: To examine the baseline occurrence, severity, and clinical correlates of suicidal ideation in adults with NF. Method: Individuals with NF (N =
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Consciousness, Memory, and the Human Self: Commentary on “Consciousness as a Memory System” by Budson et al (2022) Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Amnon Dafni-Merom, Shahar Arzy
Philosophical theories have attempted to shed light on the intricate relationships between consciousness and memory since long before this became a major theme in psychology and neuroscience. In the December 2022 issue of Cognitive and Behavioral Neurology, Budson, Richman, and Kensinger (2022) introduced a comprehensive theoretical framework pertaining to the origins of consciousness in relation to
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Commentary on “Consciousness as a Memory System” by Budson, Richman, and Kensinger (2022) Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Howard S. Kirshner
Consciouness is a phenomenon that has eluded explanation by generations of physicians and scientists. Many discussions, experiments, and theories about consciousness have been published, but none has adequately explained the phenomenon. In the previous issue, Budson and colleagues (2022) present a theory of consciousness based on explicit memory processes, with consciousness developing in the context
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Considering Individuals’ Hearing Ability Before Administering Cognitive Assessments Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Bella Brown-Quigley, Laura Gaeta
Sensory impairments such as age-related hearing loss and poor eyesight have been associated with a negative impact on cognitive screening test scores. Many researchers use cognitive tests and consider factors such as vision and cardiac issues but do not account for hearing loss. We reviewed published literature in the field of gerontology to determine if hearing loss was considered in human subjects
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Blurred Lines: Memory, Perceptions, and Consciousness: Commentary on “Consciousness as a Memory System” by Budson et al (2022) Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Hinze Hogendoorn
In the previous issue, Budson, Richman, and Kensinger (2022) put forth the intriguing proposal that consciousness may have evolved from the episodic memory system. In addition to providing a possible evolutionary trajectory for consciousness, I believe that viewing consciousness as an extension of memory in this way is particularly useful for understanding some of the puzzling temporal complexities
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Preliminary Validation Study of the French-Quebec Version of the Mild Behavioral Impairment Checklist Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Émilie Pépin, Noémie Tanguay, Marie-Pier Roy, Joël Macoir, Marie-Andrée Bruneau, Zahinoor Ismail, Carol Hudon
Background: Alzheimer disease dementia may be preceded by cognitive stages during which behavioral and psychological changes can occur. More precisely, behavioral symptoms may be observed during the subjective cognitive decline (SCD) or the mild cognitive impairment (MCI) stages; these symptoms can be measured using the Mild Behavioral Impairment Checklist (MBI–C). Objective: To validate the French-Quebec
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Effect of Dopaminergic Therapy on Impulse Control Disorders in Patients With a Prolactinoma Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Esin Ozdeniz Varan, Hakan Gurvit
Background: Studies have reported an increase in the incidence of impulse control disorders (ICDs) in patient groups treated with dopamine agonists (DAAs), especially in Parkinson disease (PD). However, very few studies have reported on ICDs in individuals with a prolactinoma who were treated with DAAs. Objective: To see whether a DAA by itself causes ICDs in individuals with a prolactinoma by controlling
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A Functional and Neuroanatomical Model of Dehumanization Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-03-01 Mario F. Mendez
The dehumanization of others is a major scourge of mankind; however, despite its significance, physicians have little understanding of the neurobiological mechanisms for this behavior. We can learn much about dehumanization from its brain–behavior localization and its manifestations in people with brain disorders. Dehumanization as an act of denying to others human qualities includes two major forms
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Memory for the News: Does Event Transience Matter? Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-01-19 Caroline O. Nester, Christopher Malone, Catherine Munro, Nancy Madigan, Sara Hoffschmidt, Joan Sweeney, Tyler Zink, Margaret O’Connor
Background: Health providers frequently probe patients’ recall of current and/or remote news events to determine the extent of memory loss. Impaired memory for transient events (ie, in the news for a circumscribed time) may provide information regarding the onset of cognitive impairment. Objective: To use the Transient News Events Test (TNET) to explore how memory changes over time in both older
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Understanding the Relationship Between Perseveration, Comorbid Behavioral Symptoms, Motor Decline, Functional Decline, and Self-report Accuracy in Huntington Disease Can Help Inform Clinical Practice Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-01-13 Andy M. Liu, Erin Koppel, Karen E. Anderson
Background: Perseveration is one of the most debilitating symptoms of Huntington disease (HD). Objective: To study perseveration and its relationship to comorbid behavioral symptoms, motor decline, functional decline, and subject self-report accuracy by analyzing cross-sectional data tracking individuals who have or are at risk for HD and healthy controls (HC). Method: We studied 96 individuals
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Using the LASSI-L to Detect Robust Interference Effects in Premanifest Huntington Disease Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2023-01-10 Luis A. Sierra, Clementina J. Ullman, Samuel A. Frank, Simon Laganiere
Background: Diagnosis of manifest Huntington disease (HD) is based primarily on motor symptoms, but premanifest HD (preHD) is often associated with subtle cognitive decline. The Loewenstein–Acevedo Scales for Semantic Interference and Learning (LASSI–L) is a validated verbal learning test that can be used to detect early cognitive decline. Objective: To determine the utility of the LASSI–L for detecting
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The Account of the Effect of Switch Probability on Switch and Mixing Costs: An ERP Study in a Cued Task-switching Paradigm Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-12-01 Cheng Wenwen, Yan Yang, Liyan Cui, Ying Chen, Weiguo Zhang, Xiong Zhang, Shu Zhou
Background: Whether the effect of switch probability on switch and mixing costs is explained by an activation or preparation account is unclear. Objective: To investigate the account of the effect of switch probability on switch and mixing costs. Method: We used a cued task-switching paradigm with three switch probabilities (high, 75%; medium, 50%; and low, 25%) with 19 healthy young adults and
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Consciousness as a Memory System Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-12-01 Andrew E. Budson, Kenneth A. Richman, Elizabeth A. Kensinger
We suggest that there is confusion between why consciousness developed and what additional functions, through continued evolution, it has co-opted. Consider episodic memory. If we believe that episodic memory evolved solely to accurately represent past events, it seems like a terrible system—prone to forgetting and false memories. However, if we believe that episodic memory developed to flexibly and
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Somatoform Symptoms in Parkinson Disease Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-12-01 David Glovinsky, Ann L. Gruber-Baldini, Seth Himelhoch, Karen E. Anderson, Lisa M. Shulman
Background: Co-occurring somatoform symptoms complicate the diagnosis and treatment of Parkinson disease (PD). Objective: To learn more about the relationship between somatoform symptoms and PD by comparing demographic and clinical features across PD groups differing in somatoform symptom severity. Method: Using standardized Brief Symptom Inventory—18 (BSI–18) scores to measure somatoform symptom
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Constructional Impairments and Their Neural Correlates in Nondemented Adults With Cerebral Autosomal-dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-12-01 Natascia De Lucia, Michele Ragno, Cristina Paci, Gabriella Cacchiò, Anna Rita Caiazzo, Sara Tiberi, Anna De Rosa, Riccardo Navarra, Massimo Caulo, Giuseppe De Michele, Luigi Trojano
Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small-vessel disease that is characterized by a wide range of neurologic and neuropsychological impairments. Constructional impairments have been reported in some cases but have never been assessed systematically. Objective: To evaluate constructional abilities and their
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BNT–15: Revised Performance Validity Cutoffs and Proposed Clinical Classification Ranges Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Kaitlyn Abeare, Laura Cutler, Kelly Y. An, Parveen Razvi, Matthew Holcomb, Laszlo A. Erdodi
Background: Abbreviated neurocognitive tests offer a practical alternative to full-length versions but often lack clear interpretive guidelines, thereby limiting their clinical utility. Objective: To replicate validity cutoffs for the Boston Naming Test—Short Form (BNT–15) and to introduce a clinical classification system for the BNT–15 as a measure of object-naming skills. Method: We collected
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Graph Theory Analysis of Semantic Fluency in Russian–English Bilinguals Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Vidushi Sinha, Frances Lissemore, Alan J. Lerner
Background: Semantic category fluency is a widely used task involving language, memory, and executive function. Previous studies of bilingual semantic fluency have shown only small differences between languages. Graph theory analyzes complex relationships in networks, including node and edge number, clustering coefficient, average path length, average number of direct neighbors, and scale-free and
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Nonparaneoplastic Anti-GAD Limbic Encephalitis: Seizure Outcome and Long-term Neuropsychological Follow-up After Immunotherapy Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Martha Spilioti, Andreas Kiryttopoulos, Theodora Panou, Panagiotis Simos, Haris Alexopoulos, Georgios Karafyles, Triantafillos Geroukis, Ioannis Kalevrosoglou, Vasilios Kimiskidis
Antibodies against glutamate decarboxylase (GAD-Abs), especially GAD65 antibodies, are associated with limbic encephalitis (LE) manifested by temporal lobe epilepsy and neuropsychological deficits. We present the case of a 42-year-old Greek woman with nonparaneoplastic anti-GAD LE, discussing the therapeutic management and highlighting the role of neuropsychological assessment. The patient underwent
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Phenotypic and Brain Imaging Findings Associated With a 10p Proximal Deletion Including the WAC Gene: Case Report and Literature Review Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Hilmi Bolat, Hatice Derin, Gül Ünsel-Bolat
Microarray-based techniques are an important testing method in etiological studies of intellectual disability and autism spectrum disorder. Interstitial deletion in the p11–p12 region of chromosome 10 is rare, having been reported in just 12 cases to date. Intellectual disability associated with the WAC gene in this region is referred to as DeSanto-Shinawi syndrome. Although all individuals with p11–p12
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Executive Dysfunction, Social Cognition Impairment, and Gray Matter Pathology in Myotonic Dystrophy Type 2: A Pilot Study Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Thomas Theodosiou, Foteini Christidi, Sofia Xirou, Efstratios Karavasilis, Peter Bede, Constantinos Papadopoulos, Georgios D. Argyropoulos, Panagiotis Kourtesis, Varvara Pantolewn, Panagiotis Ferentinos, Evangelia Kararizou, Georgios Velonakis, Ioannis Zalonis, Georgios Papadimas
Background: In contrast to myotonic dystrophy type 1, the cognitive and radiologic profile of myotonic dystrophy type 2 (DM2) is relatively poorly characterized. Objective: To conduct a pilot study to systematically evaluate cognitive and radiologic features in a cohort of Greek individuals with DM2. Method: Eleven genetically confirmed individuals with DM2 and 26 age- and education-matched healthy
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The Repeatable Battery for the Assessment of Neuropsychological Status, While Useful for Measuring Cognitive Changes in Manifest Huntington Disease, May Show Limited Utility in Premanifest Disease Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Andrea I. Mustafa, Jody Corey-Bloom, Ilex Beltran-Najera, Chase Snell, Jordan Castleton, Haileigh Smith, Paul E. Gilbert
Background: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is a brief, standardized neuropsychological test that assesses several areas of cognitive function. Recent studies, although sparse, have examined the use of the RBANS to detect cognitive deficits in individuals with manifest Huntington disease (HD); however, no studies have investigated its utility to detect
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Distinguishing Between Genuine and Feigned Dementia Using Event-related Potentials Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 August M. Price, Rocco Palumbo, Anna Marin, Prayerna Uppal, Cheongmin Suh, Andrew E. Budson, Katherine W. Turk
Background: Individuals with probable Alzheimer disease (AD) may perform below cutoffs on traditional, memory-based performance validity tests. Previous studies have found success using event-related potentials (ERPs) to detect feigned neurocognitive impairment in younger populations. Objective: To evaluate the utility of an auditory oddball task in conjunction with the P3b peak amplitude to distinguish
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Validation of a Mobile, Sensor-based Neurobehavioral Assessment With Digital Signal Processing and Machine-learning Analytics Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-09-01 Kelly L. Sloane, Joel A. Mefford, Zilong Zhao, Man Xu, Guifeng Zhou, Rachel Fabian, Amy E. Wright, Shenly Glenn
Background: The Miro Health Mobile Assessment Platform consists of self-administered neurobehavioral and cognitive assessments that measure behaviors typically measured by specialized clinicians. Objective: To evaluate the Miro Health Mobile Assessment Platform’s concurrent validity, test–retest reliability, and mild cognitive impairment (MCI) classification performance. Method: Sixty study participants
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Clinical Correlates of Depression and Suicidality in Huntington Disease: An Analysis of the Enroll-HD Observational Study Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Natalia P. Rocha, Madison R. Tuazon, Jorge Patino, Erin Furr Stimming, Antonio L. Teixeira
Background: Depression and suicidality are commonly experienced by Huntington disease (HD) gene carriers. Research on these behavioral symptoms is imperative, not only to increase our understanding of the symptoms and how they relate to HD, but also to contribute to improving patients’ care and quality of life. Objective: To identify clinical variables associated with a history of depression and
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Clinical Screening for Posterior Cortical Atrophy Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Mario F. Mendez, Youssef I. Khattab, Oleg Yerstein
Background: Posterior cortical atrophy (PCA) is a progressive neurologic syndrome that presents with complex visual deficits. Although PCA is most commonly a form of Alzheimer disease (AD), its early diagnosis is usually delayed due to a lack of understanding for how best to clinically screen for the syndrome. Objective: To identify neurobehavioral screening tasks for PCA—beyond simple visual constructions—that
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Disentangling Reversal-learning Impairments in Frontotemporal Dementia and Alzheimer Disease Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Khadija Ahmed, Derek G.V. Mitchell, Mervin Blair, Kristy Coleman, Stephen H. Pasternak, Ramiro Ruiz-Garcia, Elizabeth Finger
Background: Individuals with frontotemporal dementia (FTD) often present with poor decision-making, which can affect both their financial and social situations. Delineation of the specific cognitive impairments giving rise to impaired decision-making in individuals with FTD may inform treatment strategies, as different neurotransmitter systems have been associated with distinct patterns of altered
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Changes in Cognitive Functioning After Surgical Resection of Language-related, Eloquent-area, High-grade Gliomas Under Awake Craniotomy Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Kasra Hendi, Mohamad Rahmani, Amirhossein Larijani, Hamideh Ajam Zibadi, Samira Raminfard, Reza Shariat Moharari, Venelin Gerganov, Maysam Alimohamadi
Background: Dominant-hemisphere tumors, especially gliomas, as infiltrative tumors, frequently affect cognitive functioning. Establishing a balance between extensive resection, which is proven to result in longer survival, and less extensive resection, in order to maintain more cognitive abilities, is challenging. Objective: To evaluate changes in cognitive functioning before and after surgical resection
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Neurosyphilis Mimicking Behavioral Variant of Frontotemporal Dementia in a 59-Year-Old Man Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Paola Caroppo, Cristina Villa, Angelo Del Sole, Gaetano Bernardi, Silvia Carradori, Pietro Tiraboschi, Giorgio Giaccone, Sara Prioni
We present the case of a man exhibiting a clinical phenotype of behavioral variant of frontotemporal dementia (bvFTD). The man had developed psychiatric disturbances with verbal aggressiveness over a few months, followed by cognitive and frontal behavioral disorders, fulfilling the clinical criteria for bvFTD. Atrophy and hypometabolism in frontotemporal regions were consistent with the diagnosis.
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White Matter, Behavioral Neurology, and the Influence of Corticocentrism Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Christopher M. Filley
White matter in the human brain occupies roughly the same volume as gray matter but has received far less attention in behavioral neurology and related disciplines. In particular, the cerebral cortex has long dominated thinking about the organization of brain–behavior relationships. As a result, subcortical structures, including deep gray matter and, most notably, white matter, have been accorded relatively
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Volumetric Assessment of Hippocampus and Subcortical Gray Matter Regions in Alzheimer Disease and Amnestic Mild Cognitive Impairment Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Tuğberk Andaç Topkan, Nesrin Erdogan, Berrak Barutcu, Emetullah Cindil, E. Turgut Tali, Yahya Karaman
Background: Quantitative MRI assessment methods have limited utility due to a lack of standardized methods and measures for Alzheimer disease (AD) and amnestic mild cognitive impairment (aMCI). Objective: To employ a relatively new and easy-to-use quantitative assessment method to reveal volumetric changes in subcortical gray matter (GM) regions, hippocampus, and global intracranial structures as
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Delirium as a Presenting Symptom of COVID–19 Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-06-01 Brad Tyson, Ayman Shahein, Laszlo Erdodi, Leigh Tyson, Robert Tyson, Reza Ghomi, Pinky Agarwal
Background: Delirium is a common neurologic manifestation of coronavirus disease 2019 (COVID–19) in older adults who present to the emergency department (ED). Objective: To investigate clinical characteristics associated with delirium as a presenting symptom of COVID–19 in older adults and develop a logistic regression to predict the likelihood of delirium. Method: We compared clinical characteristics
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Eye-gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases and Links With Neuropsychiatric Disorders Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Kévin Polet, Solange Hesse, Adeline Morisot, Benoît Kullmann, Sandrine Louchart de la Chapelle, Alain Pesce, Galina Iakimova
Background: Facial emotion recognition (FER) is primarily and severely impaired in individuals with the behavioral variant of frontotemporal dementia (bvFTD) and is often mildy impaired in individuals with Alzheimer disease (AD) or Parkinson disease (PD). Such impairment is associated with inappropriate social behaviors. Objective: To determine whether FER impairment is linked to the use of inappropriate
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Hemodialyzed Individuals’ Left Spatial Attentional Bias Is Normalized Following Successful Kidney Transplantation Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Aleksandra Mańkowska, Kenneth M. Heilman, John B. Williamson, Bogdan Biedunkiewicz, Alicja Dębska-Ślizień, Michał Harciarek
Background: Healthy people have a leftward spatial attentional bias, called pseudoneglect. Individuals with end-stage renal disease (ESRD) who are receiving hemodialysis often demonstrate an increase in their leftward spatial attentional bias. Whereas a successful kidney transplant often improves the cognitive functions of individuals who previously received hemodialysis, the effect of a kidney transplant
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Anosognosia and Memory Encoding in Huntington Disease Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Ciaran Michael Considine, Shelby Hughes, Jessie Sellers Gibson, David Isaacs, Katherine McDonell, R. Ryan Darby, Daniel Claassen
Background: Anosognosia can manifest as an unawareness of neurobehavioral symptoms in individuals with Huntington disease (HD). Measurement of anosognosia is challenging, but the Anosognosia Scale (AS) represents a brief option with promising findings in small samples. Objective: To replicate application of the AS in a larger HD sample than previous studies in order to assess psychometrics and demographic
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Diagnostic Utility of Hippocampal Volumetric Data in a Memory Disorder Clinic Setting Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Robert Ruchinskas, Trung Nguyen, Kyle Womack, Alka Khera, Fang F. Yu, Brendan J. Kelley
Background: Hippocampal volumetric data are widely used in research but are rarely examined in clinical populations in regard to aiding diagnosis or correlating with objective memory test scores. Objective: To replicate and expand on the few prior clinical examinations of the utility of hippocampal volumetric data. We evaluated MRI volumetric data to determine (a) the degree of hippocampal loss across
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The Attention Network Test in Parkinson and Lewy Body Disease: A Systematic Review Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Jihyun Yang, Dana Pourzinal, Toby Rheinberger, David A. Copland, Katie L. McMahon, Gerard J. Byrne, Nadeeka N. Dissanayaka
Background: The Attention Network Test (ANT) is a well-established measure of efficiency for the alerting, orienting, and executive attentional networks. However, its novel application in Parkinson disease (PD) and Lewy body dementia (LBD) research more broadly has yet to be evaluated systematically. Objective: To compare and consolidate the outcomes of studies reporting use of the ANT in PD and
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Verbal and Nonverbal Memory in Neurodegenerative and Stroke Aphasia: Evidence From the Turkish Version of the Three Words Three Shapes Test Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Mustafa Seckin, Begüm Özbek, İlayda Demir, Elif Kurt, Ulaş Ay, Düzgün Yildirim, Nilüfer Yeşilot, Oğuzhan Çoban, Öget Öktem, Hakan Gürvit
Background: Although language impairment is the most salient feature of cognitive impairment in both primary progressive aphasia (PPA) and stroke aphasia (SA), memory can also be impaired in both patient populations. Objective: To identify distinctive features of verbal and nonverbal memory processing in individuals with PPA and those with SA. Method: We gave individuals with PPA (n = 14), those
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Sustained Long-term Improvement in Neuropsychiatric Symptoms of an Individual With Initial bvFTD Diagnosis: A Case Report Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2022-03-01 Esther S. Kim, Neil H. Pliskin, Maria T. Caserta
The behavioral variant of frontotemporal dementia (bvFTD) is a neurodegenerative disease that is diagnosed by progressive neuropsychiatric changes and supportive neuroimaging. Making an accurate diagnosis of bvFTD is a challenging process that can be complicated by the presence of a subset of nonprogressive, or phenocopy, cases whose symptoms remain stable. Our patient, who presented with neuropsychiatric
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Intellectual Curiosity and Action Initiation are Subtypes of Apathy Affected in Huntington Disease Gene Expansion Carriers Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Rebecca K. Hendel, Marie N.N. Hellem, Lena E. Hjermind, Jørgen E. Nielsen, Asmus Vogel
Background: Apathy is a prevalent behavioral syndrome of Huntington disease (HD) that can result in severe loss of function for the individual with HD and substantial caregiver distress. Research-based evidence of apathy is characterized by methodological differences, and there is a deficiency in the evidence concerning the subtypes of apathy. Objective: To characterize apathy in premanifest and
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Effects of Cognitive Reserve on Cognition in Individuals With Central Nervous System Disease Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Varna R. Jammula, Heather Leeper, Mark R. Gilbert, Diane Cooper, Terri S. Armstrong
Cognitive reserve (CR) has been proposed to account for functional outcome differences in brain pathology and its clinical manifestations. The purpose of our paper is to systematically review the effects of CR on cognitive outcomes in individuals with neurodegenerative and structural CNS diseases. We performed a systematic search of PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature)
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Diffusion Tensor Imaging Correlates of Resilience Following Adolescent Traumatic Brain Injury Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Adam T. Schmidt, Hannah M. Lindsey, Emily Dennis, Elisabeth A. Wilde, Brian D. Biekman, Zili D. Chu, Gerri R. Hanten, Dana L. Formon, Matthew S. Spruiell, Jill V. Hunter, Harvey S. Levin
Background: Traumatic brain injury (TBI) is associated with considerable mortality and morbidity in adolescents, but positive outcomes are possible. Resilience is the concept that some individuals flourish despite significant adversity. Objective: To determine if there is a relationship between resilience-promoting factors that are known to promote resilience and white matter (WM) microstructure
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Honorific Speech Impairment: A Characteristic Sign of Frontotemporal Dementia Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Weon Kyeong Hong, Ji Hye Yoon, Hyemin Jang, Soo Jin Yoon, So Young Moon, Hee Jin Kim, Duk L. Na
Background: Individuals with the behavioral variant of frontotemporal dementia (bvFTD) exhibit various levels of abulia, disinhibition, impaired judgment, and decline in executive function. Empirical evidence has shown that individuals with bvFTD also often exhibit difficulty using honorific speech, which expresses respect to another party or addressee. Objective: To analyze differences in the ability
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Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Petra Bago Rožanković, Marjan Rožanković, Jasna Badžak, Maristela Stojić, Ivana Šušak Sporiš
Background: Behavioral and psychological symptoms of dementia (BPSD) are common in individuals with Alzheimer disease (AD). Donepezil and memantine are both widely used for the treatment of moderate AD. Objective: To evaluate the effects of donepezil and memantine in relieving BPSD in individuals with moderate AD. Method: We conducted a prospective, randomized, 6-month clinical trial involving 85
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Dynamic Aphasia as a Variant of Frontotemporal Dementia Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Adithya Chandregowda, Heather M. Clark, Joseph R. Duffy, Mary M. Machulda, Val J. Lowe, Jennifer L. Whitwell, Keith A. Josephs
We describe two individuals with progressive verbal difficulty who exhibited impairment of propositional language, with relatively well-preserved auditory comprehension, naming, and repetition—a profile that is consistent with dynamic aphasia. By providing a brief review of pertinent literature and the results from our neurologic, speech and language, neuropsychological, and neuroimaging testing, this
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Cerebellar Ischemia Presenting as Transient Global Amnesia Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2021-12-01 Jonathan Morena, Hera A. Kamdar, Amir Adeli
Transient global amnesia (TGA) consists of acute-onset anterograde amnesia and typically resolves within 24 hours. Reported etiologies of TGA include transient ischemia to the hippocampus or thalamus, migraine, venous flow abnormalities, and epilepsy. There are no reports of cerebellar ischemia as an etiology of TGA. A 78-year-old woman with a medical history of diabetes presented to the Ohio State
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Concussion (What Do I Do Now?). Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-02 Howard S Kirshner
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Morality and the Brain: The Right Hemisphere and Doing Right. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Christopher M Filley,Isaiah Kletenik,Patricia S Churchland
Morality, the set of shared attitudes and practices that regulate individual behavior to facilitate cohesion and well-being, is a function of the brain, yet its localization is uncertain. Neuroscientific study of morality has been conducted by examining departures from moral conduct after neurologic insult and by functional neuroimaging of moral decision-making in cognitively intact individuals. These
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Differential Diagnosis of Cognitive Decline in Elderly Individuals With Multiple Sclerosis. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Dejan Jakimovski,Kinga Szigeti,Michael Jaworski,Aya Ouf,Bianca Weinstock-Guttman,Robert Zivadinov,Ralph H B Benedict
Due to increasingly improved disability outcomes, and the resultant significantly improved life span, of the multiple sclerosis (MS) population, questions regarding cognitive aging and the prevalence of comorbid Alzheimer disease (AD) have emerged. We describe neuropsychological and MRI-based changes that occurred in an 84-year-old MS patient with comorbid amnestic mild cognitive impairment (a precursor
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Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Vincent Paquin,Joseph Therriault,Tharick Ali Pascoal,Pedro Rosa-Neto,Serge Gauthier
The frontal variant of Alzheimer disease (fvAD) is characterized by behavioral and/or dysexecutive impairments that can resemble those of behavioral-variant frontotemporal dementia (bvFTD). This overlap, in addition to the lack of consensus clinical criteria for fvAD, complicates its identification. We provide the first case report of fvAD differentiated in vivo from bvFTD using amyloid-beta and tau
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Reversible Splenial Lesion Syndrome (RESLES) After Chemotherapy of Oral Tegafur-uracil in a Female With Locally Rectal Adenocarcinoma. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Yu-Xing Ge,Ying-Ying Lin,Qian-Qian Bi,Yu-Juan Chen
A 42-year-old woman with reversible splenial lesion syndrome (RESLES) and rectal adenocarcinoma presented with sudden-onset delirium after the sixth cycle of her chemotherapy drug, oral tegafur-uracil (300 mg/m/day, days 1-14, with treatment cycle repeated every 21 days). Accompanied by the anti-CV2 antibody, paraphasia, and a loss of bimanual coordination, the patient's etiology and clinical manifestations
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Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Francesca Bartesaghi,Chiara Emilia Rosci,Cecilia Rassiga,Valentina Barbieri,Orsola Gambini,Stefano Floro,Andrea Maria D'Arrigo,Angelo Del Sole,Elio Angelo Scarpini,Daniela Galimberti,Alberto Priori
The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this
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Nonconvulsive Status Epilepticus With Neuropsychological Symptoms: Two Case Reports. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Yuichiro Inatomi,Makoto Nakajima,Toshiro Yonehara
Nonconvulsive status epilepticus with neuropsychological symptoms other than aphasia or amnesia is rare. We report two such cases. Case 1, a 62-year-old man with a history of a subcortical hemorrhage in the right lateral temporal lobe and a brain infarct in the left medial temporo-occipital lobes, suddenly developed left unilateral spatial neglect and visual object agnosia. Diffusion-weighted imaging
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Dyskinetopsic Palinopsia: Palinopsia Accompanied by Moving Afterimages. Cogn. Behav. Neurol. (IF 1.4) Pub Date : 2020-12-01 Durjoy Lahiri,Alfredo Ardila,Subham Chatterjee,Souvik Dubey,Biman Kanti Ray
Palinopsia refers to the abnormal persistence, or recurrence, of visual images after a visual stimulus has subsided. We describe here a case of palinopsia accompanied by a visual motion perception disorder as manifested by moving afterimages. A 71-year-old man presented to us after having experienced acute-onset, vivid, visual hallucinations for 1 week. A detailed history revealed that he was hallucinating