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Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease. J. Stroke (IF 8.2) Pub Date : 2024-01-30 Litao Wang, Qiong Liu, Dongqi Yue, Jun Liu, Yi Fu
Cerebral amyloid angiopathy (CAA) has been proven to be the most common pathological change in cerebral small vessel disease except arteriosclerosis. In recent years, with the discovery of imaging technology and new imaging markers, the diagnostic rate of CAA has greatly improved. CAA plays an important role in non-hypertensive cerebral hemorrhage and cognitive decline. This review comprehensively
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Update of Anticoagulation Use in Cardioembolic Stroke With a Special Reference to Endovascular Treatment. J. Stroke (IF 8.2) Pub Date : 2024-01-30 Apostolos Safouris, Klearchos Psychogios, Lina Palaiodimou, Peter Orosz, George Magoufis, Odysseas Kargiotis, Aikaterini Theodorou, Theodore Karapanayiotides, Stavros Spiliopoulos, Sándor Nardai, Amrou Sarraj, Thanh N Nguyen, Shadi Yaghi, Silke Walter, Simona Sacco, Guillaume Turc, Georgios Tsivgoulis
Cardioembolic stroke is a major cause of morbidity, with a high risk of recurrence, and anticoagulation represents the mainstay of secondary stroke prevention in most patients. The implementation of endovascular treatment in routine clinical practice complicates the decision to initiate anticoagulation, especially in patients with early hemorrhagic transformation who are considered at higher risk of
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Emerging Concept of Intracranial Arterial Diseases: The Role of High Resolution Vessel Wall MRI. J. Stroke (IF 8.2) Pub Date : 2024-01-30 Dong-Wan Kang, Do Yeon Kim, Jonguk Kim, Sung Hyun Baik, Cheolkyu Jung, Nishita Singh, Jae W Song, Hee-Joon Bae, Beom Joon Kim
Intracranial arterial disease (ICAD) is a heterogeneous condition characterized by distinct pathologies, including atherosclerosis. Advances in magnetic resonance technology have enabled the visualization of intracranial arteries using high-resolution vessel wall imaging (HR-VWI). This review summarizes the anatomical, embryological, and histological differences between the intracranial and extracranial
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Standard Versus Intensive Blood Pressure Control in Acute Ischemic Stroke Patients Successfully Treated With Endovascular Thrombectomy: A Systemic Review and Meta-Analysis of Randomized Controlled Trials. J. Stroke (IF 8.2) Pub Date : 2024-01-30 Hyungjong Park, Sung-Il Sohn, Gwang Hyun Leem, Minho Kim, Yun Hak Kim, Tae-Jin Song
The optimal blood pressure (BP) control after successful endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) with large vessel occlusion (LVO) remains debatable. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluate the efficacy and safety of standard BP control (with systolic BP ≤180 mm Hg) versus intensive BP control (systolic BP <140 mm
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Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion. J. Stroke (IF 8.2) Pub Date : 2024-01-30 Yorito Hattori, Yoshinori Kakino, Yuji Hattori, Mari Iwashita, Hitoshi Uchiyama, Kotaro Noda, Takeshi Yoshimoto, Hidehiro Iida, Masafumi Ihara
Carotid artery stenosis or occlusion (CASO) is a causative disease of vascular cognitive impairment (VCI) attributed to cerebral hypoperfusion, even without the development of symptomatic ischemic stroke. Preclinically, resveratrol has been demonstrated to play an important role in improving cognitive function in rodent CASO models. This study investigated the association between long-term resveratrol
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Thrombectomy in Stroke Patients With Low Alberta Stroke Program Early Computed Tomography Score: Is Modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 Superior to mTICI 2b? J. Stroke (IF 8.2) Pub Date : 2024-01-30 Sameh Samir Elawady, Brian Fabian Saway, Hidetoshi Matsukawa, Kazutaka Uchida, Steven Lin, Ilko Maier, Pascal Jabbour, Joon-Tae Kim, Stacey Quintero Wolfe, Ansaar Rai, Robert M Starke, Marios-Nikos Psychogios, Edgar A Samaniego, Adam Arthur, Shinichi Yoshimura, Hugo Cuellar, Jonathan A Grossberg, Ali Alawieh, Daniele G Romano, Omar Tanweer, Justin Mascitelli, Isabel Fragata, Adam Polifka, Joshua Osbun
Outcomes following mechanical thrombectomy (MT) are strongly correlated with successful recanalization, traditionally defined as modified Thrombolysis in Cerebral Infarction (mTICI) ≥2b. This retrospective cohort study aimed to compare the outcomes of patients with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS; 2-5) who achieved mTICI 2b versus those who achieved mTICI 2c/3 after
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Association Between Anemia and Clinical Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Treatment. J. Stroke (IF 8.2) Pub Date : 2024-01-22 Angelique Ceulemans, Florentina M E Pinckaers, Alida A Postma, Wim H van Zwam, Robert J van Oostenbrugge
Endovascular treatment (EVT) is the preferred treatment option in eligible acute ischemic stroke (AIS) patients with a large vessel occlusion of the anterior circulation. Several comorbidities have been identified that can affect clinical outcomes. Various studies have investigated the association between anemia and clinical outcome and found conflicting results. The aim is to investigate the association
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Association Between Slow Ventricular Response and Severe Stroke in Atrial Fibrillation-Related Cardioembolic Stroke. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Sang Hee Ha,Soo Jeong,Jae Young Park,So Young Yang,Myung-Jin Cha,Min-Soo Cho,Jun Young Chang,Dong-Wha Kang,Sun U Kwon,Bum Joon Kim
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Patent Foramen Ovale, Old Patients, and Atrial Fibrillation. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Jong S Kim
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Acute Infarct Segmentation on Diffusion-Weighted Imaging Using Deep Learning Algorithm and RAPID MRI. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Wi-Sun Ryu,You-Ri Kang,Yoon-Gon Noh,Jong-Hyeok Park,Dongmin Kim,Byeong C Kim,Man-Seok Park,Beom Joon Kim,Joon-Tae Kim
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Occupational Risk Factors for Stroke: A Comprehensive Review. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Munyoung Yang, Hyoungseob Yoo, Seo-Young Kim, Ohwi Kwon, Min-Woo Nam, Kwang Hyun Pan, Mo-Yeol Kang
For primary prevention, it is important for public health and clinical medicine to identify and characterize modifiable risk factors of stroke. In existing literature, the impact of occupational variables on ischemic and hemorrhagic stroke has been extensively studied. This review summarizes the available data on the significance of occupational variables in stroke. The results of this review suggest
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Cerebrovascular Events in Older Patients With Patent Foramen Ovale: Current Status and Future Perspectives. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Julio I Farjat-Pasos, Angel Chamorro, Sylvain Lanthier, Mathieu Robichaud, Siddhartha Mengi, Christine Houde, Josep Rodés-Cabau
Patent foramen ovale (PFO) closure, along with medical therapy, has emerged as the therapeutic gold standard in younger (<60-year-old) patients with a PFO-related stroke for preventing recurrent events. However, PFO management guidelines lack definite recommendations for older (>60 years) patients with a PFO-related cerebrovascular event, a complex group of patients who were mostly excluded from PFO
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Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Qi Wang, Huajie Dai, Tianzhichao Hou, Yanan Hou, Tiange Wang, Hong Lin, Zhiyun Zhao, Mian Li, Ruizhi Zheng, Shuangyuan Wang, Jieli Lu, Yu Xu, Ruixin Liu, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng, Min Xu
We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR).
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Mode of Imaging Study and Endovascular Therapy for a Large Ischemic Core: Insights From the RESCUE-Japan LIMIT. J. Stroke (IF 8.2) Pub Date : 2023-09-26 Fumihiro Sakakibara, Kazutaka Uchida, Shinichi Yoshimura, Nobuyuki Sakai, Hiroshi Yamagami, Kazunori Toyoda, Yuji Matsumaru, Yasushi Matsumoto, Kazumi Kimura, Reiichi Ishikura, Manabu Inoue, Kumiko Ando, Atsushi Yoshida, Kanta Tanaka, Takeshi Yoshimoto, Junpei Koge, Mikiya Beppu, Manabu Shirakawa, Takeshi Morimoto
Differences in measurement of the extent of acute ischemic stroke using the Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) by non-contrast computed tomography (CT-ASPECTS stratum) and diffusion-weighted imaging (DWI-ASPECTS stratum) may impact the efficacy of endovascular therapy (EVT) in patients with a large ischemic core.
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Patent Foramen Ovale May Decrease the Risk of Left Atrial Thrombosis in Stroke Patients With Atrial Fibrillation. J. Stroke (IF 8.2) Pub Date : 2023-09-06 Minyoul Baik,Chi Young Shim,Seo-Yeon Gwak,Young Dae Kim,Hyo Suk Nam,Soyoung Jeon,Hye Sun Lee,Ji Hoe Heo
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Chronic Lung Parenchymal Disease May Be Causally Associated With Cryptogenic Stroke With Massive Right-to-Left Shunt. J. Stroke (IF 8.2) Pub Date : 2023-09-06 Jong-Su Kim,Eung-Joon Lee,Han-Yeong Jeong,Keun-Hwa Jung
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Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5-24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study. J. Stroke (IF 8.2) Pub Date : 2023-08-24 Lu Wang, Ying-Jie Dai, Yu Cui, Hong Zhang, Chang-Hao Jiang, Ying-Jie Duan, Yong Zhao, Ye-Fang Feng, Shi-Mei Geng, Zai-Hui Zhang, Jiang Lu, Ping Zhang, Li-Wei Zhao, Hang Zhao, Yu-Tong Ma, Cheng-Guang Song, Yi Zhang, Hui-Sheng Chen
Intravenous tenecteplase (TNK) efficacy has not been well demonstrated in acute ischemic stroke (AIS) beyond 4.5 hours after onset. This study aimed to determine the effect of intravenous TNK for AIS within 4.5 to 24 hours of onset.
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Clinical and Safety Outcomes of Endovascular Therapy 6 to 24 Hours After Large Vessel Occlusion Ischemic Stroke With Tandem Lesions. J. Stroke (IF 8.2) Pub Date : 2023-08-23 Milagros Galecio-Castillo, Mudassir Farooqui, Ameer E Hassan, Mouhammad A Jumaa, Afshin A Divani, Marc Ribo, Michael Abraham, Nils H Petersen, Johanna T Fifi, Waldo R Guerrero, Amer M Malik, James E Siegler, Thanh N Nguyen, Sunil Sheth, Albert J Yoo, Guillermo Linares, Nazli Janjua, Darko Quispe-Orozco, Wondwossen Tekle, Syed F Zaidi, Sara Y Sabbagh, Marta Olivé-Gadea, Tiffany Barkley, Reade De Leacy
Effect of endovascular therapy (EVT) in acute large vessel occlusion (LVO) patients with tandem lesions (TLs) within 6-24 hours after last known well (LKW) remains unclear. We evaluated the clinical and safety outcomes among TL-LVO patients treated within 6-24 hours.
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Anesthetic Management and Outcomes of Endovascular Treatment of Basilar Artery Occlusion: Results From the ATTENTION Registry. J. Stroke (IF 8.2) Pub Date : 2023-08-23 Chunrong Tao, Guangxiong Yuan, Pengfei Xu, Hao Wang, Peiyang Zhou, Tingyu Yi, Kai Li, Tao Cui, Jun Gao, Rui Li, Jun Sun, Chao Zhang, Li Wang, Tianlong Liu, Jianlong Song, Yamei Yin, Thanh N Nguyen, Qing Li, Wei Hu
To examine the clinical and safety outcomes after endovascular treatment (EVT) for acute basilar artery occlusion (BAO) with different anesthetic modalities.
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Digital Therapeutics With Visual Discrimination Training for Cortical Blindness in Patients With Chronic Stroke. J. Stroke (IF 8.2) Pub Date : 2023-08-10 Eun-Jae Lee,Dongho Kim,Yong-Hwan Kim,Eun Namgung,Jee-Hyun Lee,Yuka Sasaki,Takeo Watanabe,Dong-Wha Kang
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Association of Unfavorable Social Determinants of Health With Stroke/Transient Ischemic Attack and Vascular Risk Factors in Hispanic/Latino Adults: Results From Hispanic Community Health Study/Study of Latinos. J. Stroke (IF 8.2) Pub Date : 2023-08-10 Gabriela Trifan, Linda C Gallo, Melissa Lamar, Olga Garcia-Bedoya, Krista M Perreira, Amber Pirzada, Gregory A Talavera, Sylvia W Smoller, Carmen R Isasi, Jianwen Cai, Martha L Daviglus, Fernando D Testai
Social determinants of health (SDOH) are non-medical factors that may contribute to the development of diseases, with a higher representation in underserved populations. Our objective is to determine the association of unfavorable SDOH with self-reported stroke/transient ischemic attack (TIA) and vascular risk factors (VRFs) among Hispanic/Latino adults living in the US.
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Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Christopher Traenka,Johannes Lorscheider,Christian Hametner,Philipp Baumgartner,Jan Gralla,Mauro Magoni,Nicolas Martinez-Majander,Barbara Casolla,Katharina Feil,Rosario Pascarella,Panagiotis Papanagiotou,Annika Nordanstig,Visnja Padjen,Carlo W Cereda,Marios Psychogios,Christian H Nolte,Andrea Zini,Patrik Michel,Yannick Béjot,Andreas Kastrup,Marialuisa Zedde,Georg Kägi,Lars Kellert,Hilde Henon,Sami
BACKGROUND AND PURPOSE This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD). METHODS This multinational cohort study was conducted based on prospectively collected
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Antiplatelet Therapy May Be Insufficient to Prevent Stroke Recurrence Before Percutaneous Patent Foramen Ovale Closure. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Hiroyuki Kawano,Yuko Honda,Takashi Johno,Hibiku Maruoka,Kaoru Nakanishi,Mikito Saito,Kensuke Ogata,Atsushi Yamamichi,Ayane Kawatake,Teruyuki Hirano
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Timing and Predictors of Recanalization After Anticoagulation in Cerebral Venous Thrombosis. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Setareh Salehi Omran,Liqi Shu,Allison Chang,Neal S Parikh,Adeel S Zubair,Alexis N Simpkins,Mirjam R Heldner,Arsany Hakim,Sami Al Kasab,Thanh Nguyen,Piers Klein,Eric D Goldstein,Maria Cristina Vedovati,Maurizio Paciaroni,David S Liebeskind,Shadi Yaghi,Shawna Cutting
BACKGROUND AND PURPOSE Vessel recanalization after cerebral venous thrombosis (CVT) is associated with favorable outcomes and lower mortality. Several studies examined the timing and predictors of recanalization after CVT with mixed results. We aimed to investigate predictors and timing of recanalization after CVT. METHODS We used data from the multicenter, international AntiCoagulaTION in the Treatment
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Borderzone Infarcts and Recurrent Cerebrovascular Events in Symptomatic Intracranial Arterial Stenosis: A Systematic Review and Meta-Analysis. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Saurav Das,Liqi Shu,Rebecca J Morgan,Asghar Shah,Fayez H Fayad,Eric D Goldstein,Dalia Chahien,Benton Maglinger,Satish Kumar Bokka,Cory Owens,Mehdi Abbasi,Alexandra Kvernland,James E Siegler,Brian Mac Grory,Thanh N Nguyen,Karen Furie,Pooja Khatri,Eva Mistry,Shyam Prabhakaran,David S Liebeskind,Jose G Romano,Adam de Havenon,Lina Palaiodimou,Georgios Tsivgoulis,Shadi Yaghi
BACKGROUND AND PURPOSE Intracranial arterial stenosis (ICAS)-related stroke occurs due to three primary mechanisms with distinct infarct patterns: (1) borderzone infarcts (BZI) due to impaired distal perfusion, (2) territorial infarcts due to distal plaque/thrombus embolization, and (3) plaque progression occluding perforators. The objective of the systematic review is to determine whether BZI secondary
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Endovascular Thrombectomy for Large Ischemic Strokes: A Living Systematic Review and Meta-Analysis of Randomized Trials. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Rami Z Morsi,Mohamed Elfil,Hazem S Ghaith,Mohammad Aladawi,Ahmad Elmashad,Sachin Kothari,Harsh Desai,Shyam Prabhakaran,Fawaz Al-Mufti,Tareq Kass-Hout
BACKGROUND AND PURPOSE New studies have shown that endovascular thrombectomy (EVT) is safe and effective for acute ischemic stroke (AIS) patients with large ischemic areas. The aim of our study is to conduct a living systematic review and meta-analysis of randomized trials comparing EVT versus medical management only. METHODS We searched MEDLINE, Embase, and the Cochrane Library to identify randomized
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Prevalence of Amyloid Cerebral Deposits and Cognitive Outcome After Stroke: The IDEA3 Study. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Olivier Godefroy,Mélanie Barbay,Jeanne Martin,Trevor Shields,Chantal Lamy,Audrey Courselle-Arnoux,Sandrine Canaple,Claire Leclercq,Martine Roussel,Marc-Etienne Meyer,Etienne Marchal,Frank A Wollenweber,
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The Impact of Genetically Proxied AMPK Activation, the Target of Metformin, on Functional Outcome Following Ischemic Stroke. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Mengmeng Wang,Zhizhong Zhang,Marios K Georgakis,Ville Karhunen,Dandan Liu
BACKGROUND AND PURPOSE We performed a two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of genetically proxied AMP-activated protein kinase (AMPK) activation, which is the target of metformin, on functional outcome following ischemic stroke onset. METHODS A total of 44 AMPK-related variants associated with HbA1c (%) were used as instruments for AMPK activation. The primary
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Tissue Clock Beyond Time Clock: Endovascular Thrombectomy for Patients With Large Vessel Occlusion Stroke Beyond 24 Hours. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Ghada A Mohamed,Raul G Nogueira,Muhammed Amir Essibayi,Hassan Aboul-Nour,Mahmoud Mohammaden,Diogo C Haussen,Aldo Mendez Ruiz,Bradley A Gross,Okkes Kuybu,Mohamed M Salem,Jan-Karl Burkhardt,Brian Jankowitz,James E Siegler,Pratit Patel,Taryn Hester,Santiago Ortega-Gutierrez,Mudassir Farooqui,Milagros Galecio-Castillo,Thanh N Nguyen,Mohamad Abdalkader,Piers Klein,Jude H Charles,Vasu Saini,Dileep R Yavagal
BACKGROUND AND PURPOSE Randomized trials proved the benefits of mechanical thrombectomy (MT) for select patients with large vessel occlusion (LVO) within 24 hours of last-known-well (LKW). Recent data suggest that LVO patients may benefit from MT beyond 24 hours. This study reports the safety and outcomes of MT beyond 24 hours of LKW compared to standard medical therapy (SMT). METHODS This is a retrospective
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Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation: A Pilot Randomized Trial. J. Stroke (IF 8.2) Pub Date : 2023-05-30 Jong S Kim,Kyung-Bok Lee,Dae-Il Chang,Jae-Kwan Cha,Ji Sung Lee
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Circulating Extracellular-Vesicle-Incorporated MicroRNAs as Potential Biomarkers for Ischemic Stroke in Patients With Cancer. J. Stroke (IF 8.2) Pub Date : 2023-05-02 Oh Young Bang,Eun Hee Kim,Mi Jeong Oh,Jaein Yoo,Gyun Sik Oh,Jong-Won Chung,Woo-Keun Seo,Gyeong-Moon Kim,Myung-Ju Ahn,Seong Wook Yang,
BACKGROUND AND PURPOSE This study aimed to evaluate whether extracellular-vesicle-incorporated microRNAs (miRNAs) are potential biomarkers for cancer-related stroke. METHODS This cohort study compared patients with active cancer who had embolic stroke of unknown sources (cancer-stroke group) with patients with only cancer, patients with only stroke, and healthy individuals (control groups). The expression
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Moderate-Intensity Rosuvastatin Plus Ezetimibe Versus High-Intensity Rosuvastatin for Target Low-Density Lipoprotein Cholesterol Goal Achievement in Patients With Recent Ischemic Stroke: A Randomized Controlled Trial. J. Stroke (IF 8.2) Pub Date : 2023-04-11 Keun-Sik Hong,Oh Young Bang,Jong-Ho Park,Jin-Man Jung,Sang-Hun Lee,Tae-Jin Song,Hyo Suk Nam,Hee-Kwon Park,Keun-Hwa Jung,Sung Hyuk Heo,Jaseong Koo,Kyung-Ho Yu,Kwang-Yeol Park,Chi Kyung Kim,Hong-Kyun Park,Jiyoon Lee,Juneyoung Lee,Woo-Keun Seo
BACKGROUND AND PURPOSE Moderate-intensity statin plus ezetimibe versus high-intensity statin alone may provide a greater low-density lipoprotein cholesterol (LDL-C) reduction in patients with recent ischemic stroke. METHODS This randomized, open-label, controlled trial assigned patients with recent ischemic stroke <90 days to rosuvastatin/ezetimibe 10/10 mg once daily (ROS10/EZT10) or to rosuvastatin
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Endovascular Treatment of Distal-M2 Segment Occlusions: A Clinical Registry and Meta-Analysis. J. Stroke (IF 8.2) Pub Date : 2023-03-23 Sacha Bensoussan,Stephanos Nikolaos Finitsis,Bertrand Lapergue,Gaultier Marnat,Igor Sibon,Solène Moulin,Jean-Marc Olivot,Sébastien Richard,Charlotte Rosso,Benjamin Gory,Frédéric Clarençon,
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Genotype-Phenotype Correlation of the RNF213 R4810K Variant in Moyamoya Disease. J. Stroke (IF 8.2) Pub Date : 2023-03-15 Taedong Ok,Yo Han Jung,Kyung-Yul Lee
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Occurrence of Ischemic Stroke in Patients With Atrial Fibrillation Receiving Non-Vitamin K Oral Anticoagulants: Causes and Prevention Strategies. J. Stroke (IF 8.2) Pub Date : 2023-03-15 Oh Young Bang, Kyoung-Min Park, Dong Seop Jeong
Atrial fibrillation (AF) is a leading cause of cardioembolic stroke, which is often fatal or disabling. Prevention of stroke is crucial in AF management, and anticoagulation with non-vitamin K oral anticoagulants (NOACs) is the mainstay of AF management for stroke prevention. Because NOAC prescriptions have been surging worldwide, the development of acute ischemic stroke in patients with AF who receive
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Thrombus Enhancement Sign May Differentiate Embolism From Arteriosclerosis-Related Large Vessel Occlusion. J. Stroke (IF 8.2) Pub Date : 2023-03-13 Yan Zhang,Guangchen He,Jing Lu,Guihua Miao,Da Liang,Jiangliang Wang,Liming Wei,Jiangshan Deng,Yueqi Zhu
BACKGROUND AND PURPOSE To evaluate whether the thrombus enhancement sign (TES) can be used to differentiate embolic large vessel occlusion (LVO) from in situ intracranial atherosclerotic stenosis (ICAS)-related LVO in the anterior circulation of patients with acute ischemic stroke (AIS). METHODS Patients with LVO in the anterior circulation who underwent both non-contrast computed tomography (CT) and
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Collateral Circulation in Ischemic Stroke: An Updated Review. J. Stroke (IF 8.2) Pub Date : 2023-03-13 Gino Maguida,Ashfaq Shuaib
The collateral circulation plays a crucial role in maintaining perfusion to brain tissue in ischemic stroke, which prolongs the time window for effective therapies to be provided and ultimately avoids irreversible damage that may lead to worse clinical outcomes. The understanding of this complex vascular bypass system has advanced greatly in the past few years, yet effective treatments for its potentiation
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The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Jin Soo Lee,Ji Sung Lee,Byoung Joo Gwag,Dennis W Choi,Chun San An,Hyun Goo Kang,Tae-Jin Song,Seong Hwan Ahn,Chang Hun Kim,Dong-Ick Shin,Sun U Kwon
BACKGROUND AND PURPOSE Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion models. This phase III trial aims to determine this effect in patients. DESIGN The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz is
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Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Mohamad Abdalkader,James E Siegler,Jin Soo Lee,Shadi Yaghi,Zhongming Qiu,Xiaochuan Huo,Zhongrong Miao,Bruce C V Campbell,Thanh N Nguyen
Advances in acute ischemic stroke (AIS) treatment have been contingent on innovations in neuroimaging. Neuroimaging plays a pivotal role in the diagnosis and prognosis of ischemic stroke and large vessel occlusion, enabling triage decisions in the emergent care of the stroke patient. Current imaging protocols for acute stroke are dependent on the available resources and clinicians' preferences and
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The 10th Korea-Japan Joint Stroke Conference (KJJSC) at Osaka: The First-Ever and Hopefully, the Last Virtual Conference. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Kazunori Toyoda,Sohei Yoshimura,Kanta Tanaka,Kuniaki Ogasawara,Joung-Ho Rha
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Endovascular versus Medical Management of Acute Basilar Artery Occlusion: A Systematic Review and Meta-Analysis of the Randomized Controlled Trials. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Mohamad Abdalkader,Stephanos Finitsis,Chuanhui Li,Wei Hu,Xinfeng Liu,Xunming Ji,Xiaochuan Huo,Fana Alemseged,Zhongming Qiu,Daniel Strbian,Volker Puetz,James E Siegler,Shadi Yaghi,Kaiz Asif,Piers Klein,Yuyou Zhu,Bruce C V Campbell,Hui-Sheng Chen,Simon Nagel,Georgios Tsivgoulis,Zhongrong Miao,Raul G Nogueira,Tudor G Jovin,Wouter J Schonewille,Thanh N Nguyen,
BACKGROUND AND PURPOSE The optimal management of patients with acute basilar artery occlusion (BAO) is uncertain. We aimed to evaluate the safety and efficacy of endovascular thrombectomy (EVT) compared to medical management (MM) for acute BAO through a meta-analysis of randomized controlled trials (RCTs). METHODS We performed a systematic review and meta-analysis of RCTs of patients with acute BAO
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Wall Shear Stress Associated with Stroke Occurrence and Mechanisms in Middle Cerebral Artery Atherosclerosis. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Ho Geol Woo,Hyug-Gi Kim,Kyung Mi Lee,Sang Hee Ha,HangJin Jo,Sung Hyuk Heo,Dae-Il Chang,David S Liebeskind,Bum Joon Kim
BACKGROUND AND PURPOSE Various mechanisms are involved in the etiology of stroke caused by atherosclerosis of the middle cerebral artery (MCA). Here, we compared differences in plaque nature and hemodynamic parameters according to stroke mechanism in patients with MCA atherosclerosis. METHODS Consecutive patients with asymptomatic and symptomatic MCA atherosclerosis (≥50% stenosis) were enrolled. MCA
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Explanatory Power and Prognostic Implications of Factors Associated with Troponin Elevation in Acute Ischemic Stroke. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Sung-Ho Ahn,Ji-Sung Lee,Mi-Sook Yun,Jung-Hee Han,Soo-Young Kim,Young-Hak Kim,Sang-Hyun Lee,Min-Gyu Park,Kyung-Pil Park,Dong-Wha Kang,Jong S Kim,Sun U Kwon
BACKGROUND AND PURPOSE We investigated the impact of comorbidity burden on troponin elevation, with separate consideration of neurological conditions, in patients with acute ischemic stroke (AIS). METHODS This prospective, observational cohort study consecutively enrolled patients with AIS for 2 years. Serum cardiac troponin I was repeatedly measured, and disease-related biomarkers were collected for
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Replacing Alteplase with Tenecteplase: Is the Time Ripe? J. Stroke (IF 8.2) Pub Date : 2023-01-31 Nishita Singh,Bijoy K Menon,Adam A Dmytriw,Robert W Regenhardt,Joshua A Hirsch,Aravind Ganesh
Thrombolysis for acute ischemic stroke has predominantly been with alteplase for over a quarter of a century. In recent years, with trials showing evidence of higher rates of successful reperfusion, similar safety profile and efficacy of tenecteplase (TNK) as compared to alteplase, TNK has now emerged as another potential choice for thrombolysis in acute ischemic stroke. In this review, we will focus
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Stroke in Women: A Review Focused on Epidemiology, Risk Factors, and Outcomes. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Cindy W Yoon,Cheryl D Bushnell
Stroke is a particularly important issue for women. Women account for over half of all persons who experienced a stroke. The lifetime risk of stroke is higher in women than in men. In addition, women have worse stroke outcomes than men. Several risk factors have a higher association with stroke in women than in men, and women-specific risk factors that men do not have should be considered. This focused
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Sex and Gender Differences in Stroke and Their Practical Implications in Acute Care. J. Stroke (IF 8.2) Pub Date : 2023-01-31 Johanna Ospel,Nishita Singh,Aravind Ganesh,Mayank Goyal
There are several controversies regarding the role of sex and gender in the pathophysiology and management of acute stroke. Assessing the role of sex, i.e., biological/pathophysiological factors, and gender, i.e., sociocultural factors, in isolation is often not possible since they are closely intertwined with each other. To complicate matters even more, the functional baseline status of women and
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Trends in Venous Thromboembolism Readmission Rates after Ischemic Stroke and Intracerebral Hemorrhage. J. Stroke (IF 8.2) Pub Date : 2023-01-03 Liqi Shu,Adam de Havenon,Ava L Liberman,Nils Henninger,Eric Goldstein,Michael E Reznik,Ali Mahta,Fawaz Al-Mufti,Jennifer Frontera,Karen Furie,Shadi Yaghi
BACKGROUND AND PURPOSE Venous thromboembolism (VTE) is a life-threatening complication of stroke. We evaluated nationwide rates and risk factors for hospital readmissions with VTE after an intracerebral hemorrhage (ICH) or acute ischemic stroke (AIS) hospitalization. METHODS Using the Healthcare Cost and Utilization Project (HCUP) Nationwide Readmission Database, we included patients with a principal
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The Heart Is at Risk: Understanding Stroke-Heart-Brain Interactions with Focus on Neurogenic Stress Cardiomyopathy-A Review. J. Stroke (IF 8.2) Pub Date : 2023-01-03 Mairi Ziaka,Aristomenis Exadaktylos
In recent years, it has been convincingly demonstrated that acute brain injury may cause severe cardiac complications-such as neurogenic stress cardiomyopathy (NSC), a specific form of takotsubo cardiomyopathy. The pathophysiology of these brain-heart interactions is complex and involves sympathetic hyperactivity, activation of the hypothalamic-pituitary-adrenal axis, as well as immune and inflammatory
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Impact of Left Atrial or Left Atrial Appendage Thrombus on Stroke Outcome: A Matched Control Analysis. J. Stroke (IF 8.2) Pub Date : 2023-01-03 JoonNyung Heo,Hyungwoo Lee,Il Hyung Lee,Hyo Suk Nam,Young Dae Kim
BACKGROUND AND PURPOSE Left atrial or left atrial appendage (LA/LAA) thrombi are frequently observed during cardioembolic evaluation in patients with ischemic stroke. This study aimed to investigate stroke outcomes in patients with LA/LAA thrombus. METHODS This retrospective study included patients admitted to a single tertiary center in Korea between January 2012 and December 2020. Patients with nonvalvular
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Precision Greenness and Stroke/Transient Ischemic Attack in 249,405 US Medicare Beneficiaries. J. Stroke (IF 8.2) Pub Date : 2023-01-03 Scott C Brown,William W Aitken,Joanna Lombard,Kefeng Wang,Tatjana Rundek,Margaret M Byrne,Matthew Toro,Maria I Nardi,Jack Kardys,Abraham Parrish,José Szapocznik
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Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis. J. Stroke (IF 8.2) Pub Date : 2023-01-03 Randolph S Marshall,David S Liebeskind,John Huston Iii,Lloyd J Edwards,George Howard,James F Meschia,Thomas G Brott,Brajesh K Lal,Donald Heck,Giuseppe Lanzino,Navdeep Sangha,Vikram S Kashyap,Clarissa D Morales,Dejania Cotton-Samuel,Andres M Rivera,Adam M Brickman,Ronald M Lazar
BACKGROUND AND PURPOSE High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment in dementia, head trauma, demyelination, and stroke. We hypothesized that hemodynamic impairment, as represented by a relative time-to-peak (TTP) delay on MRI in the hemisphere
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Practical Nomogram Predicting Apixaban or Rivaroxaban Concentrations from Low-Molecular-Weight Heparin Anti-Xa Values: Special Interest in Acute Ischemic Stroke Patients. J. Stroke (IF 8.2) Pub Date : 2023-01-03 Charlyne Brakta,Alain Stépanian,Peggy Reiner,Maxime Delrue,Mikaël Mazighi,Emmanuel Curis,Virginie Siguret
BACKGROUND AND PURPOSE In patients with acute ischemic stroke (AIS) using a direct oral factor-Xa anticoagulant (DOAC) during the last 48 hours, a fixed plasma heparin-calibrated anti-Xa activity (0.5 IU/mL) was proposed as a threshold below which patients could be eligible for thrombolysis and/or thrombectomy. Besides, specific DOAC-calibrated anti-Xa thresholds up to 50 ng/mL have been proposed.
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Mechanical Thrombectomy for Acute Ischemic Stroke in Metastatic Cancer Patients: A Nationwide Cross-Sectional Analysis. J. Stroke (IF 8.2) Pub Date : 2023-01-03 Hassan Aboul-Nour,Ahmed Maraey,Ammar Jumah,Mahmoud Khalil,Ahmed M Elzanaty,Hadeer Elsharnoby,Fawaz Al-Mufti,Alex Bou Chebl,Daniel J Miller,Stephan A Mayer
BACKGROUND AND PURPOSE Mechanical thrombectomy (MT) is the standard treatment for large vessel occlusion (LVO) acute ischemic stroke. Patients with active malignancy have an increased risk of stroke but were excluded from MT trials. METHODS We searched the National Readmission Database for LVO patients treated with MT between 2016-2018 and compared the characteristics and outcomes of cancer-free patients
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Diabetes and Stroke: What Are the Connections? J. Stroke (IF 8.2) Pub Date : 2023-01-03 Ofri Mosenzon,Alice Yy Cheng,Alejandro A Rabinstein,Simona Sacco
Stroke is a major cause of death and long-term disability worldwide. Diabetes is associated with an increased risk of cardiovascular complications, including stroke. People with diabetes have a 1.5-2 times higher risk of stroke compared with people without diabetes, with risk increasing with diabetes duration. These risks may also differ according to sex, with a greater risk observed among women versus
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Association of Substantia Nigra Degeneration with Poor Neurological Recovery in Basal Ganglia Infarctions. J. Stroke (IF 8.2) Pub Date : 2022-12-06 Kijeong Lee,HyungWoo Lee,Young Dae Kim,Hyo Suk Nam,Hye Sun Lee,Joonsang Yoo,Sunghee Cho,Ji Hoe Heo
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Cerebral Edema in Patients with severe Hemispheric Syndrome: Incidence, Risk Factors, and Outcomes-Data from SITS-ISTR. J. Stroke (IF 8.2) Pub Date : 2022-12-06 Irene Escudero-Martínez,Magnus Thorén,Peter Ringleb,Ana Paiva Nunes,Manuel Cappellari,Viiu-Marika Rand,Piotr Sobolewski,Jose Egido,Danilo Toni,Shih-Yin Chen,Nicole Tsao,Niaz Ahmed
BACKGROUND AND PURPOSE Cerebral edema (CED) in ischemic stroke can worsen prognosis and about 70% of patients who develop severe CED die if treated conservatively. We aimed to describe incidence, risk factors and outcomes of CED in patients with extensive ischemia. METHODS Oservational study based on Safe Implementation of Treatments in Stroke-International Stroke Treatment Registry (2003-2019). Severe
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Automated Composition Analysis of Thrombus from Endovascular Treatment in Acute Ischemic Stroke Using Computer Vision. J. Stroke (IF 8.2) Pub Date : 2022-09-30 JoonNyung Heo,Young Seog,Hyungwoo Lee,Il Hyung Lee,Sungeun Kim,Jang-Hyun Baek,Hyungjong Park,Kwon-Duk Seo,Gyu Sik Kim,Han-Jin Cho,Minyoul Baik,Joonsang Yoo,Jinkwon Kim,Jun Lee,Yoon-Kyung Chang,Tae-Jin Song,Jung Hwa Seo,Seong Hwan Ahn,Heow Won Lee,Il Kwon,Eunjeong Park,Young Dae Kim,Hyo Suk Nam
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Air Pollution and Subarachnoid Hemorrhage Mortality: A Stronger Association in Women than in Men. J. Stroke (IF 8.2) Pub Date : 2022-09-30 Jeongeun Hwang,Hahn Yi,Miso Jang,Joong-Goo Kim,Sun U Kwon,Namkug Kim,Eun-Jae Lee
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Characteristics of Early Presenters after Intracerebral Hemorrhage. J. Stroke (IF 8.2) Pub Date : 2022-09-30 Andrea Morotti,Jawed Nawabi,Frieder Schlunk,Loris Poli,Paolo Costa,Federico Mazzacane,Giorgio Busto,Elisa Scola,Francesco Arba,Laura Brancaleoni,Sebastiano Giacomozzi,Luigi Simonetti,Michele Laudisi,Anna Cavallini,Massimo Gamba,Mauro Magoni,Roberto Gasparotti,Alessandro Padovani,Alessandro Pezzini,Andrea Zini,Enrico Fainardi,Ilaria Casetta