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Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases Exp. Neurol. (IF 5.3) Pub Date : 2024-03-18 Liang Kou, Yiming Wang, Jingwen Li, Wenkai Zou, Zongjie Jin, Sijia Yin, Xiaosa Chi, Yadi Sun, Jiawei Wu, Tao Wang, Yun Xia
The intricate functional interactions between mitochondria and lysosomes play a pivotal role in maintaining cellular homeostasis and proper cellular functions. This dynamic interplay involves the exchange of molecules and signaling, impacting cellular metabolism, mitophagy, organellar dynamics, and cellular responses to stress. Dysregulation of these processes has been implicated in various neurodegenerative
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The role of glia in the dysregulation of neuronal spinogenesis in Ube3a-dependent ASD Exp. Neurol. (IF 5.3) Pub Date : 2024-03-18 Zachary Gardner, Otto Holbrook, Yuan Tian, KathrynAnn Odamah, Heng-Ye Man
Overexpression of the gene and the resulting increase in Ube3a protein are linked to autism spectrum disorder (ASD). However, the cellular and molecular processes underlying -dependent ASD remain unclear. Using both male and female mice, we find that neurons in the somatosensory cortex of the 2× Tg ASD mouse model display reduced dendritic spine density and increased immature filopodia density. Importantly
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Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of hyperreflexia after spinal cord injury in rat Exp. Neurol. (IF 5.3) Pub Date : 2024-03-16 Dillon C. Malloy, Marie-Pascale Côté
Spasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals with spinal cord injury (SCI) and currently lacks adequate treatment options. This sensorimotor condition is burdensome as hyperexcitability of reflex pathways result in exacerbated reflex responses, co-contractions of antagonistic muscles, and involuntary movements. Transcutaneous spinal cord stimulation (tSCS)
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MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived extracellular vesicles promotes axon regeneration by targeting Tgif1 Exp. Neurol. (IF 5.3) Pub Date : 2024-03-16 Meng Cong, Jiyu Li, Lijuan Wang, Chang Liu, Mengru Zheng, Qiang Zhou, Mingzhi Du, Xinli Ye, Min Feng, Yujiao Ye, Shuyu Zhang, Wenqing Xu, Yi Lu, Cheng Wang, Yingjie Xia, Huimin Xie, Yide Zhang, Qianru He, Leilei Gong, Yun Gu, Hualin Sun, Qi Zhang, Jian Zhao, Fei Ding, Xiaosong Gu, Songlin Zhou
Nerve injury often leads to severe dysfunction because of the lack of axon regeneration in adult mammal. Intriguingly a series of extracellular vesicles (EVs) have the obvious ability to accelerate the nerve repair. However, the detailed molecular mechanisms to describe that EVs switch neuron from a transmitter to a regenerative state have not been elucidated. This study elucidated the microRNA (miRNA)
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Neuroligin1 in excitatory synapses contributes to long-term cognitive impairments after repeated neonatal sevoflurane exposures Exp. Neurol. (IF 5.3) Pub Date : 2024-03-15 Hui Zhang, Yingqiao Niu, Peng Yuan, Wenbo Liu, Wei Zhu, Jie Sun
Repeated sevoflurane exposures in neonatal rats may lead to neuronal apoptosis affecting long-term cognitive function, the mechanism is unknown. Neuroligin1 (NL1) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals. Herein, we explore the role of NL1 in hippocampal excitatory synapses on long-term cognitive impairments induced by repeated
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Pharmacological and stem cell therapy of stroke in animal models: Do they accurately reflect the response of humans? Exp. Neurol. (IF 5.3) Pub Date : 2024-03-14 Mihai Ruscu, Daniela Glavan, Roxana Surugiu, Thorsten R. Doeppner, Dirk M. Hermann, Andrei Gresita, Bogdan Capitanescu, Aurel Popa-Wagner
Cerebrovascular diseases are the second leading cause of death worldwide. Despite significant research investment, the only available therapeutic options are mechanical thrombectomy and tissue plasminogen activator thrombolysis. None of the more than a thousand drugs tested on animal models have proven successful in human clinical trials. Several factors contribute to this poor translation of data
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MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo Exp. Neurol. (IF 5.3) Pub Date : 2024-03-12 Emily C. Kelly-Castro, Rebecca Shear, Ankitha H. Dindigal, Maitreyee Bhagwat, Huaye Zhang
Dendritic spines play a pivotal role in synaptic communication and are crucial for learning and memory processes. Abnormalities in spine morphology and plasticity are observed in neurodevelopmental and neuropsychiatric disorders, yet the underlying signaling mechanisms remain poorly understood. The microtubule affinity regulating kinase 1 (MARK1) has been implicated in neurodevelopmental disorders
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The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents Exp. Neurol. (IF 5.3) Pub Date : 2024-03-12 Hugh H. Chan, Nicole D. Mathews, Hemen Khanna, Nymisha Mandava, Olivia Hogue, Andre G. Machado, Kenneth B. Baker
Despite great advances in acute care and rehabilitation, stroke remains the leading cause of motor impairment in the industrialized world. We have developed a deep brain stimulation (DBS)-based approach for post-stroke rehabilitation that has shown reproducible effects in rodent models and has been recently translated to humans. Mechanisms underlying the rehabilitative effects of this novel therapy
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Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications Exp. Neurol. (IF 5.3) Pub Date : 2024-03-11 Melanie Widmann, Andreas Lieb, Barbara Fogli, Angela Steck, Anna Mutti, Christoph Schwarzer
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological
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Floralozone regulates MiR-7a-5p expression through AMPKα2 activation to improve cognitive dysfunction in vascular dementia Exp. Neurol. (IF 5.3) Pub Date : 2024-03-07 Yu-Ting Song, Shan-Shan Li, Chun-Yan Chao, Shuang-Guo, Gui-Zi Chen, Shuang-Xi Wang, Ming-Xiang Zhang, Ya-Ling Yin, Peng Li
The pathogenesis of vascular dementia (VD) is complex, and currently, no effective treatments have been recommended. Floralozone is a colorless liquid first discovered in Gaertn. Recently, its medicinal value has been increasingly recognized. Our previous study has demonstrated that Floralozone can improve cognitive dysfunction in rats with VD by regulating the transient receptor potential melastatin
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Corrigendum to ‘Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats’ [Experimental Neurology 371 (2024) 114585] Exp. Neurol. (IF 5.3) Pub Date : 2024-03-06 Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
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Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease Exp. Neurol. (IF 5.3) Pub Date : 2024-02-29 Huiping Xu, Han Xiao, Qiqiang Tang
Cerebral small vessel disease (CSVD) is a cerebral vascular disease with insidious onset and poor clinical treatment effect, which is related to neuroinflammation. This study investigated whether lipopolysaccharide-induced intestinal inflammation enhanced the level of pyroptosis in the brain of rats with CSVD. The bilateral carotid artery occlusion (BCAO) model was selected as the object of study.
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BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury Exp. Neurol. (IF 5.3) Pub Date : 2024-02-23 Haining Liu, Chen Li, Xiaofeng Zhang, Hui Chen, Qi Zhang, Yuting Zeng, Shuqi Zheng, Jihua Zou, Yijin Zhao, Xiaoyan Zheng, Guozhi Huang, Qing Zeng
The complex pathophysiological changes following cerebral ischemia-reperfusion injury (CIRI) include the accumulation of defective proteins and damaged organelles, which cause massive neuron demise. To preserve cellular homeostasis, the autophagy-lysosomal pathway (ALP) is crucial for neurons to dispose of these substances. Many studies have shown that bone mesenchymal stem cell exosomes (BMSC-Exos)
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Engineered PDGFA-ligand-modified exosomes delivery T3 for demyelinating disease targeted therapy Exp. Neurol. (IF 5.3) Pub Date : 2024-02-22 Li-Bin Wang, Bao-Ying Liao, Yong-Jun Li, Zhen-Hai Wang, Yang Yu, Xing Li, Qing-Hua Zhang
Demyelination is a proper syndrome in plenty of central nervous system (CNS) diseases, which is the main obstacle to recovery and still lacks an effective treatment. To overcome the limitations of the brain-blood barrier on drug permeability, we modified an exosome secreted by neural stem cells (NSCs), which had transfected with lentivirus armed with platelet-derived growth factors A (PDGFA)-ligand
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AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling Exp. Neurol. (IF 5.3) Pub Date : 2024-02-22 Xin Miao, Junqing Lin, Ang Li, Tao Gao, Tiexin Liu, Junjie Shen, Yi Sun, Jiabao Wei, Bingbo Bao, Xianyou Zheng
Spinal cord injury (SCI) is a disorder of the central nervous system resulting from various factors such as trauma, inflammation, tumors, and other etiologies. This condition leads to impairment in motor, sensory, and autonomic functions below the level of injury. Limitations of current therapeutic approaches prompt an investigation into therapeutic angiogenesis through persistent local expression
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State-dependent alteration of respiration in a rat model of Parkinson's disease Exp. Neurol. (IF 5.3) Pub Date : 2024-02-21 Jean Jacques Walker, Estelle Meunier, Samuel Garcia, Belkacem Messaoudi, Anne-Marie Mouly, Alexandra Veyrac, Nathalie Buonviso, Emmanuelle Courtiol
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Besides major deficits in motor coordination, patients may also display sensory and cognitive impairments, which are often overlooked despite being inherently part of the PD symptomatology. Amongst those symptoms, respiration, a key mechanism involved in the regulation of multiple physiological and neuronal processes,
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Nfe2l3 promotes neuroprotection and long-distance axon regeneration after injury in vivo Exp. Neurol. (IF 5.3) Pub Date : 2024-02-21 Agnieszka Lukomska, Matthew P. Frost, William C. Theune, Jian Xing, Mahit Gupta, Ephraim F. Trakhtenberg
Nuclear factor erythroid 2 like (Nfe2l) gene family members 1–3 mediate cellular response to oxidative stress, including in the central nervous system (CNS). However, neuronal functions of Nfe2l3 are unknown. Here, we comparatively evaluated expression of Nfe2l1, Nfe2l2, and Nfe2l3 in singe cell RNA-seq (scRNA-seq)-profiled cortical and retinal ganglion cell (RGC) CNS projection neurons, investigated
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4-PBA exerts brain-protective effects against sepsis-associated encephalopathy in a mouse model of sepsis Exp. Neurol. (IF 5.3) Pub Date : 2024-02-21 Feng Xiong, Cailin Wang, Jun Lu, Guangyang Bai, Daixing Zhou, Jianmin Ling
Neuroinflammation assumes a pivotal role in both the etiological underpinnings and the dynamic progression of sepsis-associated encephalopathy (SAE). The occurrence of cognitive deficits with SAE is associated with neuroinflammation. 4-phenyl butyrate (4-PBA) may control inflammation by inhibiting endoplasmic reticulum stress (ERS). The primary objective of this investigation is to scrutinize the effectiveness
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Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from a rat model Exp. Neurol. (IF 5.3) Pub Date : 2024-02-17 Xiyan Zhu, Xiang Chu, Hao Wang, Zhikang Liao, Hongyi Xiang, Wenbing Zhao, Li Yang, Pengfei Wu, Xing Liu, Diyou Chen, Jingru Xie, Wei Dai, Lei Li, Jianmin Wang, Hui Zhao
The utilization of explosives and chemicals has resulted in a rise in blast-induced traumatic brain injury (bTBI) in recent times. However, there is a dearth of diagnostic biomarkers and therapeutic targets for bTBI due to a limited understanding of biological mechanisms, particularly in the early stages. The objective of this study was to examine the early neuropathological characteristics and underlying
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Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses Exp. Neurol. (IF 5.3) Pub Date : 2024-02-15 Muhammed Furkan Dasdelen, Ahmet Burak Caglayan, Sezgin Er, Mustafa Caglar Beker, Nilay Ates, Janine Gronewold, Thorsten Roland Doeppner, Dirk M. Hermann, Ertugrul Kilic
Social isolation is associated with poor stroke outcome, but the underlying molecular mechanisms were largely unknown. In male Balb/C mice exposed to transient middle cerebral artery occlusion (MCAo), we examined the effects of social isolation initiated post-weaning on ischemic injury, cytokine/chemokine responses and cell signaling using a broad panel of techniques that involved immunocytochemistry
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Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury Exp. Neurol. (IF 5.3) Pub Date : 2024-02-15 John C. Aldrich, Ashley R. Scheinfeld, Sydney E. Lee, Kalina J. Dusenbery, Kathryn M. Mahach, Brigid C. Van de Veire, Laura K. Fonken, Andrew D. Gaudet
Spinal cord injury (SCI) can cause long-lasting locomotor deficits, pain, and mood disorders. Anatomical and functional outcomes are exacerbated by inflammation after SCI, which causes secondary damage. One promising target after SCI is manipulating the circadian system, which optimizes biology and behavior for time of day – including neuroimmune responses and mood-related behaviors. Circadian disruption
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Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease Exp. Neurol. (IF 5.3) Pub Date : 2024-02-15 Xiaomin Fu, Le Qu, Huamin Xu, Junxia Xie
Increasing evidence has shown that mitochondrial dysfunction and iron accumulation contribute to the pathogenesis of Parkinson's disease (PD). Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein of the Nedd4 E3 ubiquitin ligases. We have previously reported that Ndfip1 showed a neuroprotective effect in cell models of PD. However, whether Ndfip1 could protect dopaminergic neurons in PD
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PI3Kδ inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-α dependent manner Exp. Neurol. (IF 5.3) Pub Date : 2024-02-15 Jing Qiu, Yi-Han Wang, Xiu-Ming Wang, Hui-Sheng Chen
The pericytes (PCs) surrounding capillaries are vital regulators of capillary constriction. Persistent PC contraction results in the increased capillary constriction, therefore leading to the impaired cerebral blood flow (CBF) recovery after reperfusion and worsening the clinical outcomes in stroke patients. However, the potential determinants of PC functions during ischemia/reperfusion are poorly
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The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes Exp. Neurol. (IF 5.3) Pub Date : 2024-02-14 Siva Reddy Challa, Koteswara Rao Nalamolu, Casimir A. Fornal, Isidra M. Baker, Adithya Mohandass, Sahil Reddy Mada, Billy C. Wang, David M. Pinson, Sourabh Lahoti, Jeffrey D. Klopfenstein, Krishna Kumar Veeravalli
Previous studies have demonstrated that endogenous tissue-type plasminogen activator (tPA) is upregulated in the brain after an acute ischemic stroke (AIS). While mixed results were observed in genetic models, the pharmacological inhibition of endogenous tPA showed beneficial effects. Treatment with exogenous recombinant tPA exacerbated brain damage in rodent models of stroke. Despite the detrimental
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To evaluate the effect of endothelin receptor agonist IRL-1620 alone and in combination with donepezil in modulating neurodegeneration elicited by amyloid-β in rats Exp. Neurol. (IF 5.3) Pub Date : 2024-02-09 Eshani Mahajan, Anupam Raja, Amit raj Sharma, Ashish Jain, Praisy K. Prabha, Ajay Prakash, Bikash Medhi
Background: The creation of efficient therapies for Alzheimer's disease is essential since it is a serious public health problem. This investigation sought to ascertain any potential synergistic benefits of treating Alzheimer's disease with IRL-1620 monotherapy in addition to Donepezil. Additionally, the toxicity profile of IRL-1620 was evaluated using different doses (5 μg/kg,7 μg/kg,9 μg/kg). The
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microRNA-9a-5p disrupts the ELAVL1/VEGF axis to alleviate traumatic brain injury Exp. Neurol. (IF 5.3) Pub Date : 2024-02-09 Chenxi Feng, Qiuyan Tian, Xiaojuan Tang, Jian Yu, Hong Li, Changxing Geng, Lixiao Xu
Plasma microRNA (miR)-9 has been identified as a promising diagnostic biomarker for traumatic brain injury (TBI). This study aims to investigate the possible role and mechanisms of miR-9a-5p affecting TBI. Microarray-based gene expression profiling of TBI was used for screening differentially expressed miRNAs and genes. TBI rat models were established. miR-9a-5p, ELAVL1 and VEGF expression in the brain
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Assessment of lisdexamfetamine on executive function in rats: A translational cognitive research Exp. Neurol. (IF 5.3) Pub Date : 2024-02-08 Chen Jian-min, Wang Zhi-yuan, Liu Ke, Zhang Cheng, Wu Shi-xuan, Cao Yi-wei, Lu Guan-yi, Song Rui, Zhuang Xiao-mei, Li Jin, Wu Ning
Executive function, including working memory, attention and inhibitory control, is crucial for decision making, thinking and planning. Lisdexamfetamine, the prodrug of d-amphetamine, has been approved for treating attention-deficit hyperactivity disorder and binge eating disorder, but whether it improves executive function under non-disease condition, as well as the underlying pharmacokinetic and neurochemical
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Cisplatin induces BDNF downregulation in middle-aged female rat model while BDNF enhancement attenuates cisplatin neurotoxicity Exp. Neurol. (IF 5.3) Pub Date : 2024-02-08 Naomi Lomeli, Diana C. Pearre, Maureen Cruz, Kaijun Di, Joni L. Ricks-Oddie, Daniela A. Bota
Cancer-related cognitive impairments (CRCI) are neurological complications associated with cancer treatment, and greatly affect cancer survivors' quality of life. Brain-derived neurotrophic factor (BDNF) plays an essential role in neurogenesis, learning and memory. The reduction of BDNF is associated with the decrease in cognitive function in various neurological disorders. Few pre-clinical studies
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Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1G93A pigs Exp. Neurol. (IF 5.3) Pub Date : 2024-02-06 Maria Teresa Golia, Roberto Frigerio, Susanna Pucci, Francesca Sironi, Cassandra Margotta, Laura Pasetto, Camilla Testori, Elena Berrone, Francesco Ingravalle, Marcella Chiari, Alessandro Gori, Roberto Duchi, Andrea Perota, Luca Bergamaschi, Antonio D’Angelo, Giulia Cagnotti, Cesare Galli, Cristiano Corona, Valentina Bonetto, Caterina Bendotti, Marina Cretich, Sara Francesca Colombo, Claudia Verderio
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Maternal environmental enrichment protects neonatal brains from hypoxic-ischemic challenge by mitigating brain energetic dysfunction and modulating glial cell responses Exp. Neurol. (IF 5.3) Pub Date : 2024-02-05 L.E. Durán-Carabali, F.K. Odorcyk, L.K. Grun, F. Schmitz, O.V. Ramires Junior, M.R. de Oliveria, K.F. Campos, E. Hoeper, A.V.S Carvalho, S. Greggio, G.T. Venturine, E.R Zimmer, F. Barbé-Tuana, A.T.S Wyse, C.A. Netto
There is evidence that maternal milieu and changes in environmental factors during the prenatal period may exert a lasting impact on the brain health of the newborn, even in case of neonatal brain hypoxia-ischemia (HI). The present study aimed to investigate the effects of maternal environmental enrichment (EE) on HI-induced energetic and metabolic failure, along with subsequent neural cell responses
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Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Exp. Neurol. (IF 5.3) Pub Date : 2024-02-05 Huaitong Yao, Yueru Shen, Zheng Song, Along Han, Xinghan Chen, Yawen Zhang, Bing Hu
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The cellular senescence response and neuroinflammation in juvenile mice following controlled cortical impact and repetitive mild traumatic brain injury Exp. Neurol. (IF 5.3) Pub Date : 2024-02-05 Zahra F. Al-Khateeb, Hasna Boumenar, Joycee Adebimpe, Shenel Shekerzade, Siân M. Henson, Jordi L. Tremoleda, Adina T. Michael-Titus
Traumatic brain injury (TBI) is a leading cause of disability and increases the risk of developing neurodegenerative diseases. The mechanisms linking TBI to neurodegeneration remain to be defined. It has been proposed that the induction of cellular senescence after injury could amplify neuroinflammation and induce long-term tissue changes. The induction of a senescence response post-injury in the immature
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Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain Exp. Neurol. (IF 5.3) Pub Date : 2024-01-30 Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Milica Koprivica, Arianna Cembran, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeier
Repetitive mild traumatic brain injuries (r-mTBI) sustained in the military or contact sports have been associated with the accumulation of extracellular tau in the brain, which may contribute to the pathogenesis of neurodegenerative tauopathies. The expression of the apolipoprotein E4 (apoE4) isoform has been associated with higher levels of tau in the brain, and worse clinical outcomes after r-mTBI
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CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model Exp. Neurol. (IF 5.3) Pub Date : 2024-02-03 C. Gauer, K. Battis, Y. Schneider, J.B. Florio, M. Mante, H.Y. Kim, R.A. Rissman, A. Hoffmann, J. Winkler
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Neuroinflammation, blood-brain barrier dysfunction, hippocampal atrophy and delayed neurodevelopment: Contributions for a rat model of congenital Zika syndrome Exp. Neurol. (IF 5.3) Pub Date : 2024-01-30 Adriana Souza dos Santos, Meirylanne Gomes da Costa, Aline Martins Faustino, Wellington de Almeida, Chris Krebs Danilevicz, Ariadni Mesquita Peres, Bruna Carolina de Castro Saturnino, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Paulo Michel Roehe, Rachel Krolow, Carla Dalmaz, Lenir Orlandi Pereira
The congenital Zika syndrome (CZS) has been characterized as a set of several brain changes, such as reduced brain volume and subcortical calcifications, in addition to cognitive deficits. Microcephaly is one of the possible complications found in newborns exposed to Zika virus (ZIKV) during pregnancy, although it is an impacting clinical sign. This study aimed to investigate the consequences of a
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Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage Exp. Neurol. (IF 5.3) Pub Date : 2024-01-28 Yan Wu, Yao Xu, Jingshan Sun, Kun Dai, Zhong Wang, Jian Zhang
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Exploring new horizons: Emerging therapeutic strategies for pediatric stroke Exp. Neurol. (IF 5.3) Pub Date : 2024-01-24 Barbara Buccilli
Pediatric stroke presents unique challenges, and optimizing treatment strategies is essential for improving outcomes in this vulnerable population. This review aims to provide an overview of new, innovative, and potential treatments for pediatric stroke, with a primary objective to stimulate further research in this field. Our review highlights several promising approaches in the realm of pediatric
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Integrated network pharmacology, molecular docking and pharmacodynamic study reveals protective effects and mechanisms of corilagin against cerebral ischemia-induced injury Exp. Neurol. (IF 5.3) Pub Date : 2024-01-23 Daiju Tao, Xin Xia, Xiaochao Zhang, Renhua Yang, Yuan Yang, Li Zhang, Yunke Shi, Di Lv, Peng Chen, Bo He, Zhiqiang Shen
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Incomplete accumulation of perilesional reactive astrocytes exacerbates wound healing after closed-head injury by increasing inflammation and BBB disruption Exp. Neurol. (IF 5.3) Pub Date : 2024-01-23 Nitin Sawant, Airi Watanabe, Haruna Ueda, Hideyuki Okano, Mitsuhiro Morita
Wound healing after closed-head injury is a significant medical issue. However, conventional models of focal traumatic brain injury, such as fluid percussion injury and controlled cortical impact, employ mechanical impacts on the exposed cerebral cortex after craniotomy. These animal models are inappropriate for studying gliosis, as craniotomy itself induces gliosis. To address this, we developed a
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Combining physical & cognitive training with iPSC-derived dopaminergic neuron transplantation promotes graft integration & better functional outcome in parkinsonian marmosets Exp. Neurol. (IF 5.3) Pub Date : 2024-01-23 Etienne W. Daadi, Elyas S. Daadi, Thomas Oh, Mingfeng Li, Jeffrey Kim, Marcel M. Daadi
Parkinson's disease (PD) is a relentlessly progressive and currently incurable neurodegenerative disease with significant unmet medical needs. Since PD stems from the degeneration of midbrain dopaminergic (DA) neurons in a defined brain location, PD patients are considered optimal candidates for cell replacement therapy. Clinical trials for cell transplantation in PD are beginning to re-emerge worldwide
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Positive relation between dopamine neuron degeneration and metabolic connectivity disruption in the MPTP plus probenecid mouse model of Parkinson's disease Exp. Neurol. (IF 5.3) Pub Date : 2024-01-26 Margherita Tassan Mazzocco, Marcello Serra, Marco Maspero, Angela Coliva, Luca Presotto, Maria Antonietta Casu, Micaela Morelli, Rosa Maria Moresco, Sara Belloli, Annalisa Pinna
The clinical manifestation of Parkinson's disease (PD) appears when neurodegeneration is already advanced, compromising the efficacy of disease-modifying treatment approaches. Biomarkers to identify the early stages of PD are therefore of paramount importance for the advancement of the therapy of PD. In the present study, by using a mouse model of PD obtained by subchronic treatment with the neurotoxin
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Mitochondrial ferritin upregulation reduced oxidative stress and blood-brain-barrier disruption by maintaining cellular iron homeostasis in a neonatal rat model of germinal matrix hemorrhage Exp. Neurol. (IF 5.3) Pub Date : 2024-01-26 Ye Yuan, Qiuguang He, Xiao Yang, Jerry J. Flores, Lei Huang, Xu Luo, Xingyu Zhang, Zongyi Zhang, Ruihao Li, Lingui Gu, Siyuan Dong, Shiyi Zhu, Kun Yi, Mingyang Han, Lei Wu, You Zhou, John H. Zhang, Zongyi Xie, Jiping Tang
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Dietary NMN supplementation enhances motor and NMJ function in ALS Exp. Neurol. (IF 5.3) Pub Date : 2024-01-22 Samuel Lundt, Nannan Zhang, Luis Polo-Parada, Xinglong Wang, Shinghua Ding
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that causes the degeneration of motor neurons in the motor cortex and spinal cord. Patients with ALS experience muscle weakness and atrophy in the limbs which eventually leads to paralysis and death. NAD+ is critical for energy metabolism, such as glycolysis and oxidative phosphorylation, but is also involved in non-metabolic
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Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury Exp. Neurol. (IF 5.3) Pub Date : 2024-01-19 Christopher J. O'Connell, Evan L. Reeder, Jacob A. Hymore, Ryan S. Brown, Gabrielle A. Notorgiacomo, Sean M. Collins, Gary A. Gudelsky, Matthew J. Robson
Mild traumatic brain injury (mTBI) is a leading cause of disability in the United States, with neuropsychiatric disturbances such as depression, anxiety, PTSD, and social disturbances being common comorbidities following injury. The molecular mechanisms driving neuropsychiatric complications following neurotrauma are not well understood and current FDA-approved pharmacotherapies employed to ameliorate
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Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression Exp. Neurol. (IF 5.3) Pub Date : 2024-01-17 Jillian L. Seiler, Xiaowen Zhuang, Alexandra B. Nelson, Talia N. Lerner
Dopamine neurons in the substantia nigra pars compacta (SNc) synthesize and release dopamine, a critical neurotransmitter for movement and learning. SNc dopamine neurons degenerate in Parkinson's Disease (PD), causing a host of motor and non-motor symptoms. Here, we review recent conceptual advances in our basic understanding of the dopamine system – including our rapidly advancing knowledge of dopamine
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Mild repetitive TBI reduces brain-derived neurotrophic factor (BDNF) in the substantia nigra and hippocampus: A preclinical model for testing BDNF-targeted therapeutics Exp. Neurol. (IF 5.3) Pub Date : 2024-01-19 Anisha A. DSouza, Praveen Kulkarni, Craig F. Ferris, Mansoor M. Amiji, Benjamin S. Bleier
Clinical studies have consistently shown that neurodegenerative diseases (NDs) such as Parkinson's disease, Alzheimer's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease show absent or low levels of brain-derived neurotrophic factor (BDNF). Despite this relationship between BDNF and ND, only a few ND animal models have been able to recapitulate the low BDNF state, thereby hindering research
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Ischemic and hemorrhagic stroke lesion environments differentially alter the glia repair potential of neural progenitor cell and immature astrocyte grafts Exp. Neurol. (IF 5.3) Pub Date : 2024-01-18 Honour O. Adewumi, Gabriela I. Berniac, Emily A. McCarthy, Timothy M. O'Shea
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Metabotropic glutamate receptor 5 promotes blood-brain barrier recovery after traumatic brain injury Exp. Neurol. (IF 5.3) Pub Date : 2024-01-14 Jiakui Ren, Teng Yang, Heting Liu, Pengjiao Ma, Mi Zhou, Jiabo Li, Tao Li, Jianbin Sun, Wenhui He, Lunshan Xu, Shuang-Shuang Dai, Yang-Wuyue Liu
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Potential links between platelets and amyloid-β in the pathogenesis of Alzheimer's disease: Evidence from in vitro, in vivo, and clinical studies Exp. Neurol. (IF 5.3) Pub Date : 2024-01-09 Ruedeemars Yubolphan, Wasana Pratchayasakul, Nut Koonrungsesomboon, Nipon Chattipakorn, Siriporn C. Chattipakorn
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Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice Exp. Neurol. (IF 5.3) Pub Date : 2024-01-10 Max Gentenaar, Fleur L. Meulmeester, Ximaine R. van der Burg, Anna T. Hoekstra, Hazel Hunt, Jan Kroon, Willeke M.C. van Roon-Mom, Onno C. Meijer
Huntington's Disease (HD) is a progressive neurodegenerative disease caused by a mutation in the huntingtin gene. The mutation leads to a toxic gain of function of the mutant huntingtin (mHtt) protein resulting in cellular malfunction, aberrant huntingtin aggregation and eventually neuronal cell death. Patients with HD show impaired motor functions and cognitive decline. Elevated levels of glucocorticoids
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PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation Exp. Neurol. (IF 5.3) Pub Date : 2024-01-11 Mingliang Xu, Junjie Li, Lei Xia, Yehong Du, Bin Wu, Xiuyu Shi, Na Tian, Yayan Pang, Lilin Yi, Mulan Chen, Weihong Song, Zhifang Dong
Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a calcium-dependent serine proteinase that regulates the proteolytic activity of various precursor proteins and facilitates protein maturation. Dysregulation of PCSK6 expression or function has been implicated in several pathological processes including nervous system diseases. However, whether and how PCSK6 is involved in the pathogenesis of
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Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice Exp. Neurol. (IF 5.3) Pub Date : 2024-01-12 Kara Snyder, C. Edward Dixon, Jeremy Henchir, Kiersten Gorse, Vincent A. Vagni, Keri Janesko-Feldman, Patrick M. Kochanek, Travis C. Jackson
RNA binding motif 5 (RBM5) is a tumor suppressor in cancer but its role in the brain is unclear. We used conditional gene knockout (KO) mice to test if RBM5 inhibition in the brain affects chronic cortical brain tissue survival or function after a controlled cortical impact (CCI) traumatic brain injury (TBI). RBM5 KO decreased baseline contralateral hemispheric volume (p < 0.0001) and exacerbated ipsilateral
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DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice Exp. Neurol. (IF 5.3) Pub Date : 2024-01-08 Fen Zhuge, Liujie Zheng, Yuxiang Pan, Liyang Ni, Zhengwei Fu, Junping Shi, Yinhua Ni
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The acute spinal cord injury microenvironment and its impact on the homing of mesenchymal stem cells Exp. Neurol. (IF 5.3) Pub Date : 2024-01-09 Jinyi Liu, Longju Qi, Shengzhe Bao, Fangsu Yan, Jiaxi Chen, Shumin Yu, Chuanming Dong
Spinal cord injury (SCI) is a highly debilitating condition that inflicts devastating harm on the lives of affected individuals, underscoring the urgent need for effective treatments. By activating inflammatory cells and releasing inflammatory factors, the secondary injury response creates an inflammatory microenvironment that ultimately determines whether neurons will undergo necrosis or regeneration
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Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke Exp. Neurol. (IF 5.3) Pub Date : 2024-01-05 Bin Sun, Jing Luo, Zhen Li, Dongfeng Chen, Qizhang Wang, Wenwen Si
As the main bioactive component of musk, muscone has been reported to have marked protective effects in treating acute ischemic stroke (AIS). However, the specific anti-stroke mechanism of muscone still needs further research. In the current investigation, the PC12 cells OGD/R and the rat transient MCAO/R models were utilized as the AIS models. Serum hepatic and renal functional indexes (ALT, AST,
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Distant neuroinflammation acutely induced by focal brain injury and its control by endocannabinoid system Exp. Neurol. (IF 5.3) Pub Date : 2024-01-06 Anna A. Karan, Yulia S. Spivak, Elena M. Suleymanova, Konstantin A. Gerasimov, Alex P. Bolshakov, Lyudmila V. Vinogradova
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GPNMB promotes peripheral nerve regeneration by activating the Erk1/2 and Akt pathways via binding Na+/K+-ATPase α1 in Schwann cells Exp. Neurol. (IF 5.3) Pub Date : 2024-01-08 Chao Huang, Yani Zheng, Ruijuan Ji, Liang Qiao, Xi Zhang, Haiyan Lin, Fang Liu, Jiajun Xu, Yuquan Li, Zhiying Zhang, Xiangqun Yang
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Chronic chemogenetic inhibition of TRPV1 bladder afferent promotes micturition recovery post SCI Exp. Neurol. (IF 5.3) Pub Date : 2024-01-08 Long Ma, Chen Zhu, Yun-Fei Wei, Jin-Yong Zhou, Min Chen, Xin Zhang, Ping Zhou, Yan Wang, Jian Wang, Can Chu, Jing-Yuan Tang, Yan Xu
Spinal cord injury often results in chronic loss of micturition control, which is featured by bladder hyperreflexia and detrusor sphincter dyssynergia. Previous studies showed that treatment of capsaicin reduces non-voiding bladder contractions in multiple animal injury models and human patients. However, its underlying neural mechanisms remain largely unknown. Here, by injecting a RetroAAV into the
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Quantifying injury expansion in the cervical spinal cord with intravital ultrafast contrast-enhanced ultrasound imaging Exp. Neurol. (IF 5.3) Pub Date : 2024-01-08 Jennifer N. Harmon, Jeffrey E. Hyde, Dylan E. Jensen, Emma C. D'cessare, Anton A. Odarenko, Matthew F. Bruce, Zin Z. Khaing
Spinal cord injury is characterized by hemodynamic disruption at the injury epicenter and hypoperfusion in the penumbra, resulting in progressive ischemia and cell death. This degenerative secondary injury process has been well-described, though mostly using ex vivo or depth-limited optical imaging techniques. Intravital contrast-enhanced ultrasound enables longitudinal, quantitative evaluation of