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Transferrin Enhances Neuronal Differentiation ASN Neuro (IF 4.7) Pub Date : 2023-04-24 María Julia Pérez, Tomas Roberto Carden, Paula Ayelen dos Santos Claro, Susana Silberstein, Pablo Martin Páez, Veronica Teresita Cheli, Jorge Correale, Juana M. Pasquini
Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a...
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Activation of the PACAP/PAC1 Signaling Pathway Accelerates the Repair of Impaired Spatial Memory Caused by an Ultradian Light Cycle ASN Neuro (IF 4.7) Pub Date : 2023-04-18 Dejiao Xu, Ying Zhang, Jun Feng, Hongyu Fu, Jiayi Li, Wei Wang, Zhen Li, Pingping Zhang, Xinqi Cheng, Liecheng Wang, Juan Cheng
The mechanism of light-induced spatial memory deficits, as well as whether rhythmic expression of the pituitary adenylyl cyclase-activating polypeptides (PACAP)-PAC1 pathway influenced by light is ...
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Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline ASN Neuro (IF 4.7) Pub Date : 2023-04-05 G.C. Nascimento, M. Bortolanza, A. Bribian, G.C. Leal-Luiz, R. Raisman-Vozari, L. López-Mascaraque, E. Del-Bel
Levo-dihydroxyphenylalanine (L-DOPA) therapy for Parkinson's disease (PD) patients improves motor symptoms, but long-term treatment induces side effects such as abnormal involuntary movements (levo...
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The Initial Myelination in the Central Nervous System ASN Neuro (IF 4.7) Pub Date : 2023-03-27 Qiang Yu, Teng Guan, Ying Guo, Jiming Kong
Myelination contributes not only to the rapid nerve conduction but also to axonal insulation and protection. In the central nervous system (CNS), the initial myelination features a multistep proces...
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Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia ASN Neuro (IF 4.7) Pub Date : 2023-03-08 Michael Ohene-Nyako, Sara R. Nass, Hope T. Richard, Robert Lukande, Melanie R. Nicol, MaryPeace McRae, Pamela E. Knapp, Kurt F. Hauser
Aberrant phosphorylation and subsequent aggregation of the trans-activation response (TAR) element DNA binding protein 43 (TDP-43) is a common feature of multiple neurodegenerative disorders and co...
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Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease ASN Neuro (IF 4.7) Pub Date : 2023-02-23 Jinjing Jia, Jiayi Yin, Yu Zhang, Guangtao Xu, Min Wang, Haiying Jiang, Li Li, Xiansi Zeng, Dongsheng Zhu
Alzheimer's disease (AD) is the most common neurodegenerative disease. Increasing studies suggest that mitochondrial dysfunction is closely related to the pathogenesis of AD. Thioredoxin-1 (Trx-1),...
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Age-Associated Upregulation of Glutamate Transporters and Glutamine Synthetase in Senescent Astrocytes In Vitro and in the Mouse and Human Hippocampus ASN Neuro (IF 4.7) Pub Date : 2023-02-22 Isadora Matias, Luan Pereira Diniz, Ana Paula Bergamo Araujo, Isabella Vivarini Damico, Pâmella de Moura, Felipe Cabral-Miranda, Fabiola Diniz, Belisa Parmeggiani, Valeria de Mello Coelho, Renata E. P. Leite, Claudia K. Suemoto, Gustavo Costa Ferreira, Regina Célia Cussa Kubrusly, Flávia Carvalho Alcantara Gomes
Aging is marked by complex and progressive physiological changes, including in the glutamatergic system, that lead to a decline of brain function. Increased content of senescent cells in the brain,...
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Pyruvate Kinase 2, an Energy Metabolism Related Enzyme, May Have a Neuroprotective Function in Retinal Degeneration ASN Neuro (IF 4.7) Pub Date : 2023-02-17 Jiaming Zhou, Per Ekström
Retinitis pigmentosa (RP) is an inherited disorder that results in vision impairment but general and mutation-independent therapeutic strategies are not available. However, it is widely regarded th...
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Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas ASN Neuro (IF 4.7) Pub Date : 2023-01-30 Eduardo Morais de Castro, Leonardo Vinícius Barbosa, Aline Simoneti Fonseca, Seigo Nagashima, Caroline Busatta Vaz de Paula, Rafaela Zeni, Letícia Arianne Panini do Carmo, Luciane R Cavalli, Luiz Fernando Bleggi Torres, Andrea Senff Ribeiro, Lucia de Noronha, Cleber Machado-Souza
Central nervous system tumors, especially astrocytomas, are the solid neoplasms with the highest incidence and mortality rates in childhood. The diagnosis is based on histopathological characterist...
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Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice ASN Neuro (IF 4.7) Pub Date : 2023-01-22 Fei Zeng, Karsten Parker, Yanqiang Zhan, Matthew Miller, Meng-Yang Zhu
Oxidative stress-induced DNA damage has been considered to constitute a unifying pathogenesis in the development of Parkinson's disease (PD). In the present study, multiple measurement methods were...
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In Memoriam, Dr. Robert K. Yu. ASN Neuro (IF 4.7) Pub Date : 2023-01-14 Thomas N Seyfried,Yutaka Itokazu,Toshio Ariga,Erhard Bieberich
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Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Astrocytes from Humanized Targeted Replacement Mice ASN Neuro (IF 4.7) Pub Date : 2023-01-05 Isha Mhatre-Winters, Aseel Eid, Yoonhee Han, Kim Tieu, Jason R. Richardson
Apolipoprotein E4 (APOE4) genotype and sex are significant risk factors for Alzheimer's disease (AD), with females demonstrating increased risk modulated by APOE genotype. APOE is predominantly exp...
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Neuroprotection by Preconditioning in Mice is Dependent on MyD88-Mediated CXCL10 Expression in Endothelial Cells ASN Neuro (IF 4.7) Pub Date : 2023-01-02 Zhihong Chen, Weiwei Hu, Mynor J. Mendez, Zachary C. Gossman, Anthony Chomyk, Brendan T. Boylan, Grahame J. Kidd, Timothy W. Phares, Cornelia C. Bergmann, Bruce D. Trapp
The central nervous system (CNS) can be preconditioned to resist damage by peripheral pretreatment with low-dose gram-negative bacterial endotoxin lipopolysaccharide (LPS). Underlying mechanisms as...
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Diazepam Binding Inhibitor Control of Eu- and Hypoglycemic Patterns of Ventromedial Hypothalamic Nucleus Glucose-Regulatory Signaling. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Sagor C Roy,Subash Sapkota,Madhu Babu Pasula,Khaggeswar Bheemanapally,Karen P Briski
Pharmacological stimulation/antagonism of astrocyte glio-peptide octadecaneuropeptide signaling alters ventromedial hypothalamic nucleus (VMN) counterregulatory γ-aminobutyric acid (GABA) and nitric oxide transmission. The current research used newly developed capillary zone electrophoresis-mass spectrometry methods to investigate hypoglycemia effects on VMN octadecaneuropeptide content, along with
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Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Cai-Yan Xue,Tian Gao,E Mao,Zhen-Zhen Kou,Ling Dong,Feng Gao
It is well known that the hippocampus is a vital brain region playing a key role in both episodic and spatial memory. Insulin receptors (InsRs) are densely distributed in the hippocampus and are important for its function. However, the effects of InsRs on the function of the specific hippocampal cell types remain elusive. In this study, hippocampal InsRs knockout mice had impaired episodic and spatial
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Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Takuya Kawamura,Gagandeep Singh Mallah,Maryam Ardalan,Tetyana Chumak,Pernilla Svedin,Lina Jonsson,Seyedeh Marziyeh Jabbari Shiadeh,Fanny Goretta,Tomoaki Ikeda,Henrik Hagberg,Mats Sandberg,Carina Mallard
Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD+) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD+ and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves
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All the PNS is a Stage: Transplanted Bone Marrow Cells Play an Immunomodulatory Role in Peripheral Nerve Regeneration. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Gonzalo Piñero,Marianela Vence,Marcos L Aranda,Magalí C Cercato,Paula A Soto,Vanina Usach,Patricia C Setton-Avruj
Bone marrow cell transplant has proven to be an effective therapeutic approach to treat peripheral nervous system injuries as it not only promoted regeneration and remyelination of the injured nerve but also had a potent effect on neuropathic pain.
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SOD1G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Soledad Marton,Ernesto Miquel,Joaquín Acosta-Rodríguez,Santiago Fontenla,Gabriela Libisch,Patricia Cassina
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by upper and lower motor neuron (MN) degeneration. Astrocytes surrounding MNs are known to modulate ALS progression. When cocultured with astrocytes overexpressing the ALS-linked mutant Cu/Zn superoxide dismutase (SOD1G93A) or when cultured with conditioned medium from SOD1G93A astrocytes, MN survival is reduced
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The α2 Adrenoceptor Agonist and Sedative/Anaesthetic Dexmedetomidine Excites Diverse Neuronal Types in the Ventrolateral Preoptic Area of Male Mice. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Sumei Fan,Xinqi Cheng,Pingping Zhang,Yuanyin Wang,Liecheng Wang,Juan Cheng
Dexmedetomidine is an important ICU sedative. The mechanism of dexmedetomidine is not fully understood. Activating NA(-) and NA(+) neurons in the VLPO by dexmedetomidine using polysomnography and electrophysiological recording, this may explain the unique sedative properties with rapid arousal.
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Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Anthony R Braun,Noah Nathan Kochen,Samantha L Yuen,Elly E Liao,Razvan L Cornea,David D Thomas,Jonathan N Sachs
There is a critical need for small molecules capable of rescuing pathophysiological phenotypes induced by alpha-synuclein (aSyn) misfolding and oligomerization. Building upon our previous aSyn cellular fluorescence lifetime (FLT)-Förster resonance energy transfer (FRET) biosensors, we have developed an inducible cell model incorporating the red-shifted mCyRFP1/mMaroon1 (OFP/MFP) FRET pair. This new
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Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Manolia R Ghouli,Carrie R Jonak,Rajan Sah,Todd A Fiacco,Devin K Binder
Volume-regulated anion channels (VRACs) are a group of ubiquitously expressed outwardly-rectifying anion channels that sense increases in cell volume and act to return cells to baseline volume through an efflux of anions and organic osmolytes, including glutamate. Because cell swelling, increased extracellular glutamate levels, and reduction of the brain extracellular space (ECS) all occur during seizure
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Müller Glia to Müller Glia Extracellular Vesicle-Dependent Signaling Induces Multipotency Genes Nestin and lin28 Expression in Response to N-methyl-D-aspartate (NMDA) Exposure. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Ana Karen Carapia,Erick J Martinez-Colin,Deisy Segura-Villalobos,Rebeca Yael Victoria-Chavez,Ivonne Lezama,Eduardo Martinez-Martinez,Monica Lamas
Retinal Müller cells secrete extracellular vesicles that can be captured by other Müller cells. In response to a signal that may be deleterious for the retina, Müller glia-derived extracellular vesicles spread instructions to induce gene expression changes in other cells.
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Sex-Dimorphic Octadecaneuropeptide (ODN) Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neuron Function and Counterregulatory Hormone Secretion. ASN Neuro (IF 4.7) Pub Date : 2023-01-01 Karen P Briski,Prabhat R Napit,Abdulrahman Alhamyani,Jérôme Leprince,A S M Hasan Mahmood
Central endozepinergic signaling is implicated in glucose homeostasis. Ventromedial hypothalamic nucleus (VMN) metabolic monitoring governs glucose counter-regulation. VMN glucose-stimulatory nitric oxide (NO) and glucose-inhibitory γ-aminobutyric acid (GABA) neurons express the energy gauge 5'-AMP-activated protein kinase (AMPK). Current research addresses the premise that the astrocyte glio-peptide
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Comparing the Characteristics of Microglia Preparations Generated Using Different Human iPSC-Based Differentiation Methods to Model Neurodegenerative Diseases ASN Neuro (IF 4.7) Pub Date : 2022-12-15 Ye Man Tang, Nisha S. Pulimood, Stefano Stifani
As the resident immune cells of the healthy nervous system, homeostatic microglia can rapidly become activated in response to injury/disease. Dysregulated microglia activation is a hallmark of nerv...
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Rab11 and Its Role in Neurodegenerative Diseases ASN Neuro (IF 4.7) Pub Date : 2022-12-04 Pinky Sultana, Jiri Novotny
Vesicles mediate the trafficking of membranes/proteins in the endocytic and secretory pathways. These pathways are regulated by small GTPases of the Rab family. Rab proteins belong to the Ras super...
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Translocation of High Mobility Group Box 1 From the Nucleus to the Cytoplasm in Depressed Patients With Epilepsy ASN Neuro (IF 4.7) Pub Date : 2022-11-16 Xiao-Li Li, Shu Wang, Chong-Yang Tang, Hao-Wei Ma, Zi-Zhang Cheng, Meng Zhao, Wei-Jin Sun, Xiong-Fei Wang, Meng-Yang Wang, Tian-Fu Li, Xue-Ling Qi, Jian Zhou, Guo-Ming Luan, Yu-Guang Guan
Depression is a common psychiatric comorbidity in patients with epilepsy, especially those with temporal lobe epilepsy (TLE). The aim of this study was to assess changes in high mobility group box ...
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Neural Stem Cells in Adult Mammals are not Astrocytes ASN Neuro (IF 4.7) Pub Date : 2022-11-04 Fernando Janczur Velloso, Sandhya Shankar, Vladimir Parpura, Pasko Rakic, Steven W. Levison
At the turn of the 21st century studies of the cells that resided in the adult mammalian subventricular zone (SVZ) characterized the neural stem cells (NSCs) as a subtype of astrocyte. Over the ens...
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Multitarget Activities of Müller Glial Cells and Low-Density Lipoprotein Receptor-Related Protein 1 in Proliferative Retinopathies ASN Neuro (IF 4.7) Pub Date : 2022-10-31 María C. Sanchez, Gustavo A. Chiabrando
Müller glial cells (MGCs), the main glial component of the retina, play an active role in retinal homeostasis during development and pathological processes. They strongly monitor retinal environmen...
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Microglia in Circumventricular Organs: The Pineal Gland Example ASN Neuro (IF 4.7) Pub Date : 2022-10-31 Estela M. Muñoz
The circumventricular organs (CVOs) are unique areas within the central nervous system. They serve as a portal for the rest of the body and, as such, lack a blood-brain barrier. Microglia are the p...
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Circadian Clock, Glucocorticoids and NF-κB Signaling in Neuroinflammation- Implicating Glucocorticoid Induced Leucine Zipper as a Molecular Link ASN Neuro (IF 4.7) Pub Date : 2022-10-31 Mythily Srinivasan, Chandler Walker
Inflammation including neuroinflammation is considered a protective response and is directed to repair, regenerate, and restore damaged tissues in the central nervous system. Persistent inflammatio...
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New Target for Prevention and Treatment of Neuroinflammation: Microglia Iron Accumulation and Ferroptosis ASN Neuro (IF 4.7) Pub Date : 2022-10-26 Shunfeng Liu, Xue Gao, Shouhong Zhou
Microglia play an important role in maintaining central nervous system homeostasis and are the major immune cells in the brain. In response to internal or external inflammatory stimuli, microglia a...
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Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner ASN Neuro (IF 4.7) Pub Date : 2022-10-11 Borna Sarker, Sandra M. Cardona, Kaira A. Church, Difernando Vanegas, Priscila Velazquez, Colin Rorex, Derek Rodriguez, Andrew S. Mendiola, Timothy S. Kern, Nadia D. Domingo, Robin Stephens, Isabel A. Muzzio, Astrid E. Cardona
Microglia-mediated inflammation plays a significant role in neuronal and vascular damage in diabetic retinopathy (DR), but the mechanism linking inflammation, neurodegeneration, and impaired vascul...
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Acute Manganese Exposure Modifies the Translation Machinery via PI3K/Akt Signaling in Glial Cells ASN Neuro (IF 4.7) Pub Date : 2022-10-06 Jzmín Soto-Verdugo, Janisse Siva-Parra, Luisa C Hernández-Kelly, Arturo Ortega
Manganese (Mn) exerts serious neurotoxic effects, among which, the disruption of the glutamate/glutamine (Glu/Gln) cycle, leads to an excitotoxic insult. The molecular mechanisms mediating Mn-induc...
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Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain ASN Neuro (IF 4.7) Pub Date : 2022-09-27 Philip A. Adeniyi, Katie-Anne Fopiano, Fatima Banine, Mariel Garcia, Xi Gong, C. Dirk Keene, Larry S. Sherman, Zsolt Bagi, Stephen A. Back
A major limitation of mechanistic studies in aging brains is the lack of routine methods to robustly visualize and discriminate the cellular distribution of tissue antigens using fluorescent immuno...
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Cuprizone-induced Demyelination in Mouse Brain is not due to Depletion of Copper ASN Neuro (IF 4.7) Pub Date : 2022-09-16 Megan L. Morgan, Wulin Teo, Yda Hernandez, Craig Brideau, Karen Cummins, Hedwich F. Kuipers, Peter K. Stys
The cuprizone (CPZ) model allows the study of the biochemical processes underlying nonautoimmune-mediated demyelination, remyelination, and chronic white matter disease progression. CPZ is a copper...
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In Utero Exposure to Zika Virus Results in sex-Specific Memory Deficits and Neurological Alterations in Adult Mice ASN Neuro (IF 4.7) Pub Date : 2022-08-25 Thiago A. Andrade, Julia S. Fahel, Jessica M. de Souza, Ana C. Terra, Danielle G. Souza, Vivian V. Costa, Mauro M. Teixeira, Enrrico Bloise, Fabiola M. Ribeiro
Transplacental transmission of Zika virus (ZIKV) during early pregnancy may lead to several neurological alterations, known as congenital Zika syndrome. We have previously shown that intravaginal i...
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Corrigendum to miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology ASN Neuro (IF 4.7) Pub Date : 2022-08-17
Walsh, A. D., Nguyen, L. T., & Binder, M. D. miRNAs in Microglia: Important Players in Multiple Sclerosis Pathology. ASN Neuro. January 2021. doi:10.1177/1759091420981182
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Multiple Sclerosis and Aging: The Dynamics of Demyelination and Remyelination ASN Neuro (IF 4.7) Pub Date : 2022-08-07 Jorge Correale, Maria Celica Ysrraelit
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination and neurodegeneration. Life expectancy and age of onset in MS patients have be...
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EAAT1-dependent slc1a3 Transcriptional Control depends on the Substrate Translocation Process ASN Neuro (IF 4.7) Pub Date : 2022-07-29 Dinorah Hernández-Melchor, Leticia Ramírez-Martínez, Luis Cid, Cecilia Palafox-Gómez, Esther López-Bayghen, Arturo Ortega
Glutamate, the major excitatory neurotransmitter in the vertebrate brain, is removed from the synaptic cleft by a family of sodium-dependent transporters expressed in neurons and glial cells. The b...
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Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis ASN Neuro (IF 4.7) Pub Date : 2022-07-06 Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage. Previous studies showe...
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Dopamine D2 and Adenosine A2A Receptors Interaction on Ca2+ Current Modulation in a Rodent Model of Parkinsonism ASN Neuro (IF 4.7) Pub Date : 2022-06-07 Ernesto Alberto Rendón-Ochoa, Montserrat Padilla-Orozco, Vladimir Melesio Calderon, Victor Hugo Avilés-Rosas, Omar Hernández-González, Teresa Hernández-Flores, María Belén Perez-Ramirez, Marcela Palomero-Rivero, Elvira Galarraga, José Bargas
Adenosine A1 and A2A receptors are expressed in striatal projection neurons (SPNs). A1 receptors are located in direct (dSPN) and indirect SPNs (iSNP). A2A receptors are only present in iSPNs. Dopa...
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GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas ASN Neuro (IF 4.7) Pub Date : 2022-06-07 Jessy V. van Asperen, Pierre A.J.T. Robe, Elly M. Hol
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the discovery ...
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Müller Cell Molecular Heterogeneity: Facts and Predictions ASN Neuro (IF 4.7) Pub Date : 2022-06-07 Monica Lamas, Erick J. Martinez-Colin
The retina was historically considered as an “approachable part of the brain”; advantageous, for its simplicity, to use as a model organ for deciphering cellular and molecular mechanisms underlying...
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Motor Learning and Physical Exercise in Adaptive Myelination and Remyelination ASN Neuro (IF 4.7) Pub Date : 2022-05-29 Mara S. Bloom, Jennifer Orthmann-Murphy, Judith B. Grinspan
The idea that myelination is driven by both intrinsic and extrinsic cues has gained much traction in recent years. Studies have demonstrated that myelination occurs in an intrinsic manner during early development and continues through adulthood in an activity-dependent manner called adaptive myelination. Motor learning, the gradual acquisition of a specific novel motor skill, promotes adaptive myelination
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Microglia at the Crossroads of Pathogen-Induced Neuroinflammation ASN Neuro (IF 4.7) Pub Date : 2022-05-29 Ana María Rodríguez, Julia Rodríguez, Guillermo Hernán Giambartolomei
Microglia are the resident tissue macrophages of the central nervous system (CNS). Recent findings point out that in the steady state the major role of microglia, is to instruct and regulate the co...
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Disruption of Synaptic Transmission in the Bed Nucleus of the Stria Terminalis Reduces Seizure-Induced Death in DBA/1 Mice and Alters Brainstem E/I Balance ASN Neuro (IF 4.7) Pub Date : 2022-05-24 Maya Xia, Benjamin Owen, Jeremy Chiang, Alyssa Levitt, Katherine Preisinger, Wen Wei Yan, Ragan Huffman, William P. Nobis
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in refractory epilepsy patients. Accumulating evidence from recent human studies and animal models suggests that seizure-related respiratory arrest may be important for initiating cardiorespiratory arrest and death. Prior evidence suggests that apnea onset can coincide with seizure spread to the amygdala and that stimulation
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Astrocyte Cell Surface Antigen 2 and Other Potential Cell Surface Markers of Enteric glia in the Mouse Colon ASN Neuro (IF 4.7) Pub Date : 2022-05-20 Vladimir Grubišić, Brian D. Gulbransen
Enteric glia regulate gut functions in health and disease through diverse interactions with neurons and immune cells. Intracellular localization of traditional markers of enteric glia such as GFAP, s100b, and Sox10 makes them incompatible for studies that require antigen localization at the cell surface. Thus, new tools are needed for probing the heterogeneous roles of enteric glia at the protein,
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Neural Functions of Hypothalamic Oxytocin and its Regulation ASN Neuro (IF 4.7) Pub Date : 2022-05-20 Ping Wang, Stephani C. Wang, Xiaoyu Liu, Shuwei Jia, Xiaoran Wang, Tong Li, Jiawei Yu, Vladimir Parpura, Yu-Feng Wang
Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT over past decades, our understanding of its neural functions and their regulation remains incomplete. OT is mainly produced in OT neurons in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and accessory nuclei between the SON and PVN. OT exerts neuromodulatory effects in the brain and spinal cord.
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Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro ASN Neuro (IF 4.7) Pub Date : 2022-05-20 Milorad Dragic, Katarina Mihajlovic, Marija Adzic, Marija Jakovljevic, Marina Zaric Kontic, Nataša Mitrović, Danijela Laketa, Irena Lavrnja, Markus Kipp, Ivana Grković, Nadezda Nedeljkovic
Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) hydrolyzes extracellular ATP to ADP, which is the ligand for P2Y1,12,13 receptors. The present study describes the distribution of NTPDase2 in adult rat brains in physiological conditions, and in hippocampal neurodegeneration induced by trimethyltin (TMT). The study also describes the regulation of NTPDase2 by inflammatory mediators in primary
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Identification of microRNA-mRNA regulatory network associated with oxidative DNA damage in human astrocytes ASN Neuro (IF 4.7) Pub Date : 2022-05-16 Chukwumaobim Daniel Nwokwu, Adam Y. Xiao, Lynn Harrison, Gergana G. Nestorova
The high lipid content of the brain, coupled with its heavy oxygen dependence and relatively weak antioxidant system, makes it highly susceptible to oxidative DNA damage that contributes to neurodegeneration. This study is aimed at identifying specific ROS-responsive miRNAs that modulate the expression and activity of the DNA repair proteins in human astrocytes, which could serve as potential biomarkers
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Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats ASN Neuro (IF 4.7) Pub Date : 2022-05-03 Martina L. Hernandez, Michael Marone, Karen M. Gorse, Audrey D. Lafrenaye
Traumatic brain injury (TBI) has consequences that last for years following injury. While TBI can precipitate a variety of diffuse pathologies, the mechanisms involved in injury-induced neuronal membrane disruption remain elusive. The lysosomal cysteine protease, Cathepsin B (Cath B), and specifically its redistribution into the cytosol has been implicated in cell death. Little is known about Cath
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KCC2 rs2297201 Gene Polymorphism Might be a Predictive Genetic Marker of Febrile Seizures ASN Neuro (IF 4.7) Pub Date : 2022-04-12 Sanja Dimitrijevic, Biljana Jekic, Suzana Cvjeticanin, Aleksandra Tucovic, Tamara Filipovic, Ivana Novaković, Bojana Ivić, Dimitrije Nikolic
Introduction: Febrile seizures (FS) are the most common neurological disease in childhood. The etiology of FS is the subject of numerous studies including studies regarding genetic predisposition. Aim: The aim of the study was to analyze the association of TRPV1 rs222747 and KCC2 rs2297201 gene polymorphisms with the occurrence of FS. Materials and Methods: The study included 112 patients diagnosed
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The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease ASN Neuro (IF 4.7) Pub Date : 2022-03-18 Cory R. Reiter, Rima Rebiai, Angelika Kwak, Jeff Marshall, Dylan Wozniak, Giusepe Scesa, Duc Nguyen, Emily Rue, Chandimal Pathmasiri, Robert Pijewski, Richard van Breemen, Stephanie Cologna, Stephen J. Crocker, M Irene Givogri, Ernesto R Bongarzone
Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Krabbe disease, is associated with secreted EVs. We evaluated the effects of attenuating EV secretion in the Twitcher brain by depleting ceramide production
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Hepatoma Derived Growth Factor Enhances Oligodendrocyte Genesis from Subventricular Zone Precursor Cells ASN Neuro (IF 4.7) Pub Date : 2022-03-16 Yutong Li, Nicole Leanne Dittmann, Adrianne Eve, Scovil Watson, Monique Marylin Alves de Almeida, Tim Footz, Anastassia Voronova
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), perform vital functions in neural protection and communication, as well as cognition. Enhanced production of oligodendrocytes has been identified as a therapeutic approach for neurodegenerative and neurodevelopmental disorders. In the postnatal brain, oligodendrocytes are generated from the neural stem and precursor cells
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Simultaneous Detection of Herpes Simplex Virus Type 1 Latent and Lytic Transcripts in Brain Tissue ASN Neuro (IF 4.7) Pub Date : 2022-02-14 Shu Zhang, Jianxiong Zeng, Yuzheng Zhou, Ruoyun Gao, Stephanie Rice, Xinying Guo, Yongzhen Liu, Pinghui Feng, Zhen Zhao
Neurotrophic herpes simplex virus type 1 (HSV-1) establishes lifelong latent infection in humans. Accumulating studies indicate that HSV-1, a risk factor of neurodegenerative diseases, exacerbates the sporadic Alzheimer's disease (AD). The analysis of viral genetic materials via genomic sequencing and quantitative PCR (qPCR) is the current approach used for the detection of HSV-1; however, this approach
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The Intrinsic Blue Light Responses of Avian Müller Glial Cells Imply Calcium Release from Internal Stores ASN Neuro (IF 4.7) Pub Date : 2022-02-01 Natalia A. Marchese, Maximiliano N. Ríos, Mario E. Guido
The retina of vertebrates is responsible for capturing light through visual (cones and rods) and non-visual photoreceptors (intrinsically photosensitive retinal ganglion cells and horizontal cells) triggering a number of essential activities associated to image- and non-image forming functions (photic entrainment of daily rhythms, pupillary light reflexes, pineal melatonin inhibition, among others)
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Optimization of Long-Term Human iPSC-Derived Spinal Motor Neuron Culture Using a Dendritic Polyglycerol Amine-Based Substrate ASN Neuro (IF 4.7) Pub Date : 2022-01-13 Louise Thiry, Jean-Pierre Clément, Rainer Haag, Timothy E Kennedy, Stefano Stifani
Human induced pluripotent stem cells (hiPSCs) derived from healthy and diseased individuals can give rise to many cell types, facilitating the study of mechanisms of development, human disease modeling, and early drug target validation. In this context, experimental model systems based on hiPSC-derived motor neurons (MNs) have been used to study MN diseases such as spinal muscular atrophy and amyotrophic
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Dendritic Polyglycerol Amine: An Enhanced Substrate to Support Long-Term Neural Cell Culture ASN Neuro (IF 4.7) Pub Date : 2022-01-13 Jean-Pierre Clément, Laila Al-Alwan, Stephen D. Glasgow, Avya Stolow, Yi Ding, Thaiany Quevedo Melo, Anouar Khayachi, Yumin Liu, Markus Hellmund, Rainer Haag, Austen J Milnerwood, Peter Grütter, Timothy E. Kennedy
Long-term stable cell culture is a critical tool to better understand cell function. Most adherent cell culture models require a polymer substrate coating of poly-lysine or poly-ornithine for the cells to adhere and survive. However, polypeptide-based substrates are degraded by proteolysis and it remains a challenge to maintain healthy cell cultures for extended periods of time. Here, we report the
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Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration ASN Neuro (IF 4.7) Pub Date : 2022-01-11 Chen Liang, Damien Carrel, Nisha K. Singh, Liam L. Hiester, Isabelle Fanget, Hyuck Kim, Bonnie L. Firestein
Neuronal migration and dendritogenesis are dependent on dynamic changes to the microtubule (MT) network. Among various factors that regulate MT dynamics and stability, post-translational modifications (PTMs) of MTs play a critical role in conferring specificity of regulatory protein binding to MTs. Thus, it is important to understand the regulation of PTMs during brain development as multiple developmental
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Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains ASN Neuro (IF 4.7) Pub Date : 2021-11-23 Fei Zeng, Yan Fan, Russell W. Brown, Wesley Drew Gill, Jennifer B. Price, Thomas C. Jones, Meng-Yang Zhu
This study investigated the effects of the pharmacological manipulation of noradrenergic activities on dopaminergic phenotypes in aged rats. Results showed that the administration of L-threo-3,4-dihydroxyphenylserine (L-DOPS) for 21 days significantly increased the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the striatum and substantia nigra (SN) of 23-month-old rats.