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Brain network hierarchy reorganization in subthreshold depression Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-18 Xiaolong Yin, Junchao Yang, Qing Xiang, Lixin Peng, Jian Song, Shengxiang Liang, Jingsong Wu
Hierarchy is the organizing principle of human brain network. How network hierarchy changes in subthreshold depression (StD) is unclear. The aim of this study was to investigate the altered brain network hierarchy and its clinical significance in patients with StD. A total of 43 patients with StD and 43 healthy controls matched for age, gender and years of education participated in this study. Alterations
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Comparative overview of multi-shell diffusion MRI models to characterize the microstructure of multiple sclerosis lesions and periplaques Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-18 Colin Vanden Bulcke, Anna Stölting, Dragan Maric, Benoît Macq, Martina Absinta, Pietro Maggi
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Structural connectivity of low-frequency subthalamic stimulation for improving stride length in Parkinson’s disease Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-18 Alexander Calvano, Urs Kleinholdermann, Amelie-Sophie Heun, Miriam H.A. Bopp, Christopher Nimsky, Lars Timmermann, David J. Pedrosa
A reduction in stride length is considered a key characteristic of gait kinematics in Parkinson’s disease (PD) and has been identified as a predictor of falls. Although low-frequency stimulation (LFS) has been suggested as a method to improve gait characteristics, the underlying structural network is not well understood. This study aims to investigate the structural correlates of changes in stride
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COVID-19 S apical lung examination study 2: A national prospective CTA biomarker study of the lung apices, in patients presenting with suspected acute stroke (COVID SALES 2) Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-15 T. Ratneswaren, N. Chan, J. Aeron-Thomas, S. Sait, O. Adesalu, M. Alhawamdeh, M. Benger, J. Garnham, L. Dixon, F. Tona, C. McNamara, E. Taylor, K. Lobotesis, E. Lim, O. Goldberg, N. Asmar, O. Evbuomwan, S. Banerjee, L. Holm-Mercer, J. Senor, Y. Tsitsiou, P. Tantrige, A. Taha, K. Ballal, A. Mattar, A. Daadipour, K. Elfergani, R. Barker, R. Chakravartty, A.G. Murchison, B.J.R. Kemp, R. Simister, I. Davagnanam
Apical ground-glass opacification (GGO) identified on CT angiography (CTA) performed for suspected acute stroke was developed in 2020 as a coronavirus-disease-2019 (COVID-19) diagnostic and prognostic biomarker in a retrospective study during the first wave of COVID-19. To prospectively validate whether GGO on CTA performed for suspected acute stroke is a reliable COVID-19 diagnostic and prognostic
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Distinctive clinical and imaging trajectories in SWEDD and Parkinson’s disease patients Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-14 Cecilia Boccalini, Nicolas Nicastro, Daniela Perani, Valentina Garibotto
A proportion of patients clinically diagnosed with Parkinson’s disease (PD) can have a I-FP-CIT-SPECT scan without evidence of dopaminergic deficit (SWEDD), generating a debate about the underlying biological mechanisms. This study investigated differences in clinical features, I-FP-CIT binding, molecular connectivity, as well as clinical and imaging progression between SWEDD and PD patients.
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On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-06 Noa van der Knaap, Marcel J.H. Ariës, Iwan C.C. van der Horst, Jacobus F.A. Jansen
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Impaired flexible reward learning in ADHD patients is associated with blunted reinforcement sensitivity and neural signals in ventral striatum and parietal cortex Neuroimage Clin. (IF 4.2) Pub Date : 2024-03-01 Hans-Christoph Aster, Maria Waltmann, Anika Busch, Marcel Romanos, Matthias Gamer, Betteke Maria van Noort, Anne Beck, Viola Kappel, Lorenz Deserno
Reward-based learning and decision-making are prime candidates to understand symptoms of attention deficit hyperactivity disorder (ADHD). However, only limited evidence is available regarding the neurocomputational underpinnings of the alterations seen in ADHD. This concerns flexible behavioral adaption in dynamically changing environments, which is challenging for individuals with ADHD. One previous
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Neurorestorative effects of cerebellar transcranial direct current stimulation on social prediction of adolescents and young adults with congenital cerebellar malformations Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-28 Viola Oldrati, Niccolò Butti, Elisabetta Ferrari, Sandra Strazzer, Romina Romaniello, Renato Borgatti, Cosimo Urgesi, Alessandra Finisguerra
Converging evidence points to impairments of the predictive function exerted by the cerebellum as one of the causes of the social cognition deficits observed in patients with cerebellar disorders. We tested the neurorestorative effects of cerebellar transcranial direct current stimulation (ctDCS) on the use of contextual expectations to interpret actions occurring in ambiguous sensory sceneries in
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A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-28 Kyle M. Jensen, Vince D. Calhoun, Zening Fu, Kun Yang, Andreia V. Faria, Koko Ishizuka, Akira Sawa, Pablo Andrés-Camazón, Brian A. Coffman, Dylan Seebold, Jessica A. Turner, Dean F. Salisbury, Armin Iraji
Psychosis (including symptoms of delusions, hallucinations, and disorganized conduct/speech) is a main feature of schizophrenia and is frequently present in other major psychiatric illnesses. Studies in individuals with first-episode (FEP) and early psychosis (EP) have the potential to interpret aberrant connectivity associated with psychosis during a period with minimal influence from medication and
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Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-28 Lijun Kang, Wei Wang, Zhaowen Nie, Qian Gong, Lihua Yao, Dan Xiang, Nan Zhang, Ning Tu, Hongyan Feng, Xiaofen Zong, Hanping Bai, Gaohua Wang, Fei Wang, Lihong Bu, Zhongchun Liu
Arterial spin labeling (ASL) can be used to detect differences in perfusion for multiple brain regions thought to be important in major depressive disorder (MDD). However, the potential of cerebral blood flow (CBF) to predict MDD and its correlations between the blood lipid levels and immune markers, which are closely related to MDD and brain function change, remain unclear. The 451 individuals − 298
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Transient resting-state salience-limbic co-activation patterns in functional neurological disorders Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-28 Samantha Weber, Janine Bühler, Serafeim Loukas, Thomas A.W. Bolton, Giorgio Vanini, Rupert Bruckmaier, Selma Aybek
Functional neurological disorders were historically regarded as the manifestation of a brain lesion which might be linked to trauma or stress, although this association has not yet been directly tested yet. Analysing large-scale brain network dynamics at rest in relation to stress biomarkers assessed by salivary cortisol and amylase could provide new insights into the pathophysiology of functional
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Behavioral and neuroanatomical correlates of facial emotion processing in post-stroke depression Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-27 Janusz L Koob, Maximilian Gorski, Sebastian Krick, Maike Mustin, Gereon R. Fink, Christian Grefkes, Anne K. Rehme
Emotion processing deficits are known to accompany depressive symptoms and are often seen in stroke patients. Little is known about the influence of post-stroke depressive (PSD) symptoms and specific brain lesions on altered emotion processing abilities and how these phenomena develop over time. This potential relationship may impact post-stroke rehabilitation of neurological and psychosocial function
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Connectivity-based segmentation of the thalamic motor region for deep brain stimulation in essential tremor: A comparison of deterministic and probabilistic tractography Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-27 Evangelia Tsolaki, Alon Kashanian, Kevin Chiu, Ausaf Bari, Nader Pouratian
Deep brain stimulation (DBS) studies have shown that stimulation of the motor segment of the thalamus based on probabilistic tractography is predictive of improvement in essential tremor (ET). However, probabilistic methods are computationally demanding, requiring the need for alternative tractography methods for use in the clinical setting. The purpose of this study was to compare probabilistic vs
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Subtle microstructural alterations in white matter tracts involved in socio-emotional processing after very preterm birth Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-19 Ward Deferm, Tiffany Tang, Matthijs Moerkerke, Nicky Daniels, Jean Steyaert, Kaat Alaerts, Els Ortibus, Gunnar Naulaers, Bart Boets
Children born very preterm (VPT, < 32 weeks of gestation) have an increased risk of developing socio-emotional difficulties. Possible neural substrates for these socio-emotional difficulties are alterations in the structural connectivity of the social brain due to premature birth. The objective of the current study was to study microstructural white matter integrity in VPT versus full-term (FT) born
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Increased iron in the substantia nigra pars compacta identifies patients with early Parkinson’s disease: A 3T and 7T MRI study Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-17 Erind Alushaj, Nicholas Handfield-Jones, Alan Kuurstra, Anisa Morava, Ravi S. Menon, Adrian M. Owen, Manas Sharma, Ali R. Khan, Penny A. MacDonald
Degeneration in the substantia nigra (SN) pars compacta (SNc) underlies motor symptoms in Parkinson’s disease (PD). Currently, there are no neuroimaging biomarkers that are sufficiently sensitive, specific, reproducible, and accessible for routine diagnosis or staging of PD. Although iron is essential for cellular processes, it also mediates neurodegeneration. MRI can localize and quantify brain iron
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Conflict monitoring and emotional processing in 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine users – A comparative neurophysiological study Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-15 Antje Opitz, Josua Zimmermann, David M. Cole, Rebecca C. Coray, Anna Zachäi, Markus R. Baumgartner, Andrea E. Steuer, Maximilian Pilhatsch, Boris B. Quednow, Christian Beste, Ann-Kathrin Stock
In stimulant use and addiction, conflict control processes are crucial for regulating substance use and sustaining abstinence, which can be particularly challenging in social-affective situations. Users of methamphetamine (METH, “Ice”) and 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) both experience impulse control deficits, but display different social-affective and addictive profiles. We thus
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Alterations in type 2 dopamine receptors across neuropsychiatric conditions: A large-scale PET cohort Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-13 Tuulia Malén, Severi Santavirta, Sven De Maeyer, Jouni Tuisku, Valtteri Kaasinen, Tuomas Kankare, Janne Isojärvi, Juha Rinne, Jarmo Hietala, Pirjo Nuutila, Lauri Nummenmaa
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Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-12 Bastian E.A. Sajonz, Marvin L. Frommer, Marco Reisert, Ganna Blazhenets, Nils Schröter, Alexander Rau, Thomas Prokop, Peter C. Reinacher, Michel Rijntjes, Horst Urbach, Philipp T. Meyer, Volker A. Coenen
Thalamic deep brain stimulation (DBS) is an efficacious treatment for drug-resistant essential tremor (ET) and the dentato-rubro-thalamic tract (DRT) constitutes an important target structure. However, up to 40% of patients habituate and lose treatment efficacy over time, frequently accompanied by a stimulation-induced cerebellar syndrome. The phenomenon termed delayed therapy escape (DTE) is insufficiently
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Aberrant brain dynamics of large-scale functional networks across schizophrenia and mood disorder Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-10 Takuya Ishida, Shinichi Yamada, Kasumi Yasuda, Shinya Uenishi, Atsushi Tamaki, Michiyo Tabata, Natsuko Ikeda, Shun Takahashi, Sohei Kimoto
The dynamics of large-scale networks, which are known as distributed sets of functionally synchronized brain regions and include the visual network (VIN), somatomotor network (SMN), dorsal attention network (DAN), salience network (SAN), limbic network (LIN), frontoparietal network (FPN), and default mode network (DMN), play important roles in emotional and cognitive processes in humans. Although disruptions
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Lesion mapping and functional characterization of hemiplegic children with different patterns of hand manipulation Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-10 Antonino Errante, Francesca Bozzetti, Alessandro Piras, Laura Beccani, Mariacristina Filippi, Stefania Costi, Adriano Ferrari, Leonardo Fogassi
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Correspondence: Inaccurate reference leads to tripling of reported FND prevalence Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-08
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Longitudinal prognosis of Parkinson’s outcomes using causal connectivity Neuroimage Clin. (IF 4.2) Pub Date : 2024-02-06 Cooper J. Mellema, Kevin P. Nguyen, Alex Treacher, Aixa X. Andrade, Nader Pouratian, Vibhash D. Sharma, Padraig O'Suileabhain, Albert A. Montillo
Despite the prevalence of Parkinson’s disease (PD), there are no clinically-accepted neuroimaging biomarkers to predict the trajectory of motor or cognitive decline or differentiate Parkinson’s disease from atypical progressive parkinsonian diseases. Since abnormal connectivity in the motor circuit and basal ganglia have been previously shown as early markers of neurodegeneration, we hypothesize that
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Response to the Letter Concerning the Publication: Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda. Perez DL et al. Neuroimage Clin. 2021;30:102623 Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-30 David L. Perez, Timothy R. Nicholson, Ali A. Asadi-Pooya, Matthew Butler, Alan J. Carson, Anthony S. David, Quinton Deeley, Ibai Diez, Mark J. Edwards, Alberto J. Espay, Jeannette M. Gelauff, Johannes Jungilligens, Mark Hallett, Richard A.A. Kanaan, Marina A.J. Tijssen, Kasia Kozlowska, W. Curt LaFrance Jr, Ramesh S. Marapin, Carine W. Maurer, Antje A.T.S. Reinders, Petr Sojka, Jeffrey P. Staab, Jon
Abstract not available
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Prenatal alcohol exposure and white matter microstructural changes across the first 6–7 years of life: A longitudinal diffusion tensor imaging study of a South African birth cohort Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-28 K.A. Donald, C.J. Hendrikse, A. Roos, C.J. Wedderburn, S. Subramoney, J.E. Ringshaw, L. Bradford, N. Hoffman, T. Burd, K.L. Narr, R.P. Woods, H.J. Zar, S.H. Joshi, D.J. Stein
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Disrupted third visual pathway function in schizophrenia: Evidence from real and implied motion processing Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-26 Antígona Martínez, Pablo A. Gaspar, Dalton H. Bermudez, M. Belen Aburto-Ponce, Odeta Beggel, Daniel C. Javitt
Impaired motion perception in schizophrenia has been associated with deficits in social-cognitive processes and with reduced activation of visual sensory regions, including the middle temporal area (MT+) and posterior superior temporal sulcus (pSTS). These findings are consistent with the recent proposal of the existence of a specific ‘third visual pathway’ specialized for social perception in which
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Characterizing upper extremity fine motor function in the presence of white matter hyperintensities: A 7 T MRI cross-sectional study in older adults Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-24 Riccardo Iandolo, Esin Avci, Giulia Bommarito, Ioanna Sandvig, Gitta Rohweder, Axel Sandvig
White matter hyperintensities (WMH) are a prevalent radiographic finding in the aging brain studies. Research on WMH association with motor impairment is mostly focused on the lower-extremity function and further investigation on the upper-extremity is needed. How different degrees of WMH burden impact the network of activation recruited during upper limb motor performance could provide further insight
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Hand function after neonatal stroke: A graph model based on basal ganglia and thalami structure Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-22 Patty Coupeau, Josselin Démas, Jean-Baptiste Fasquel, Lucie Hertz-Pannier, Stéphane Chabrier, Mickael Dinomais
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Progressive lesion necrosis is related to increasing aphasia severity in chronic stroke Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-20 Lisa Johnson, Roger Newman-Norlund, Alex Teghipco, Chris Rorden, Leonardo Bonilha, Julius Fridriksson
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Relationships among the gut microbiome, brain networks, and symptom severity in schizophrenia patients: A mediation analysis Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-17 Liqin Liang, Shijia Li, Yuanyuan Huang, Jing Zhou, Dongsheng Xiong, Shaochuan Li, Hehua Li, Baoyuan Zhu, Xiaobo Li, Yuping Ning, Xiaohui Hou, Fengchun Wu, Kai Wu
The microbiome-gut-brain axis (MGBA) plays a critical role in schizophrenia (SZ). However, the underlying mechanisms of the interactions among the gut microbiome, brain networks, and symptom severity in SZ patients remain largely unknown. Fecal samples, structural and functional magnetic resonance imaging (MRI) data, and Positive and Negative Syndrome Scale (PANSS) scores were collected from 38 SZ
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Obesity surgery and neural correlates of human eating behaviour: A systematic review of functional MRI studies Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-12 Shahd Alabdulkader, Alhanouf S. Al-Alsheikh, Alexander D. Miras, Anthony P. Goldstone
Changes in eating behaviour including reductions in appetite and food intake, and healthier food cue reactivity, reward, hedonics and potentially also preference, contribute to weight loss and its health benefits after obesity surgery. Functional magnetic resonance imaging (fMRI) has been increasingly used to interrogate the neural correlates of eating behaviour in obesity, including brain reward-cognitive
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Delineating the impact of childhood traumatic brain injury (TBI) on long-term depressive symptom severity: Does sub-acute brain morphometry prospectively predict 2-year outcome? Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-09 Nicholas P. Ryan, Dawn Koester, Louise Crossley, Edith Botchway, Stephen Hearps, Cathy Catroppa, Vicki Anderson
Despite evidence of a link between childhood TBI and heightened risk for depressive symptoms, very few studies have examined early risk factors that predict the presence and severity of post-injury depression beyond 1-year post injury. This longitudinal prospective study examined the effect of mild-severe childhood TBI on depressive symptom severity at 2-years post-injury. It also evaluated the potential
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Comparing the efficacy of awake and sedated MEG to TMS in mapping hand sensorimotor cortex in a clinical cohort Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-08 Negar Noorizadeh, Jackie Austin Varner, Liliya Birg, Theresa Williard, Roozbeh Rezaie, James Wheless, Shalini Narayana
Non-invasive methods such as Transcranial Magnetic Stimulation (TMS) and magnetoencephalography (MEG) aid in the pre-surgical evaluation of patients with epilepsy or brain tumor to identify sensorimotor cortices. MEG requires sedation in children or patients with developmental delay. However, TMS can be applied to awake patients of all ages with any cognitive abilities. In this study, we compared the
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Altered task-related decoupling of the rostral anterior cingulate cortex in depression Neuroimage Clin. (IF 4.2) Pub Date : 2024-01-08 Christine A. Leonards, Ben J. Harrison, Alec J. Jamieson, James Agathos, Trevor Steward, Christopher G. Davey
Dysfunctional activity of the rostral anterior cingulate cortex (rACC) – an extensively connected hub region of the default mode network – has been broadly linked to cognitive and affective impairments in depression. However, the nature of aberrant task-related rACC suppression in depression is incompletely understood. In this study, we sought to characterize functional connectivity of rACC activity
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Preoperative plasticity in the functional naming network of patients with left insular gliomas Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-28 Elisa Cargnelutti, Marta Maieron, Serena D'Agostini, Tamara Ius, Miran Skrap, Barbara Tomasino
Plasticity could take place as a compensatory process following brain glioma growth. Only a few studies specifically explored plasticity in patients affected by a glioma invading the left insula; even more, plasticity of the insular cortex in task-based functional language network is almost unexplored.
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Investigating neural dysfunction with abnormal protein deposition in Alzheimer’s disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-22 Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
In Alzheimer’s disease (AD), aggregated abnormal proteins induce neuronal dysfunction. Despite the evidence supporting the association between tau proteins and brain atrophy, further studies are needed to explore their link to neuronal dysfunction in the human brain. To clarify the relationship between neuronal dysfunction and abnormal proteins in AD-affected brains, we conducted magnetic resonance
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Assessing network degeneration and phenotypic heterogeneity in genetic frontotemporal lobar degeneration by decoding FDG-PET Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-22 Nick Corriveau-Lecavalier, Leland R. Barnard, Scott A. Przybelski, Venkatsampath Gogineni, Hugo Botha, Jonathan Graff-Radford, Vijay K. Ramanan, Leah K. Forsberg, Julie A. Fields, Mary M. Machulda, Rosa Rademakers, Ralitza H. Gavrilova, Maria I. Lapid, Bradley F. Boeve, David S. Knopman, Val J. Lowe, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci, David T. Jones
Genetic mutations causative of frontotemporal lobar degeneration (FTLD) are highly predictive of a specific proteinopathy, but there exists substantial inter-individual variability in their patterns of network degeneration and clinical manifestations. We collected clinical and Fluorodeoxyglucose-positron emission tomography (FDG-PET) data from 39 patients with genetic FTLD, including 11 carrying the
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Neurometabolic alterations in children and adolescents with functional neurological disorder Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-21 Molly Charney, Sheryl Foster, Vishwa Shukla, Wufan Zhao, Sam H. Jiang, Kasia Kozlowska, Alexander Lin
In vivo magnetic resonance spectroscopy (MRS) was used to investigate neurometabolic homeostasis in children with functional neurological disorder (FND) in three regions of interest: supplementary motor area (SMA), anterior default mode network (aDMN), and posterior default mode network (dDMN). Metabolites assessed included N-acetyl aspartate (NAA), a marker of neuron function; myo-inositol (mI), a
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Brain connectivity networks underlying resting heart rate variability in acute ischemic stroke Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-19 Violeta Dimova, Claudia Welte-Jzyk, Andrea Kronfeld, Oliver Korczynski, Bernhard Baier, Nabin Koirala, Livia Steenken, Bianca Kollmann, Oliver Tüscher, Marc A. Brockmann, Frank Birklein, Muthuraman Muthuraman
Acute strokes can affect heart rate variability (HRV), the mechanisms how are not well understood. We included 42 acute stroke patients (2–7 days after ischemic stroke, mean age 66 years, 16 women). For analysis of HRV, 20 matched controls (mean age 60.7, 10 women) were recruited. HRV was assessed at rest, in a supine position and individual breathing rhythmus for 5 min. The coefficient of variation
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Mapping neurodevelopment with sleep macro- and micro-architecture across multiple pediatric populations Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-19 N. Kozhemiako, A.W. Buckley, R.D. Chervin, S. Redline, S.M. Purcell
Profiles of sleep duration and timing and corresponding electroencephalographic activity reflect brain changes that support cognitive and behavioral maturation and may provide practical markers for tracking typical and atypical neurodevelopment. To build and evaluate a sleep-based, quantitative metric of brain maturation, we used whole-night polysomnography data, initially from two large National Sleep
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Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-18 Inga Aarts, Chris Vriend, Odile A. van den Heuvel, Kathleen Thomaes
Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown. We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs
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Large-scale effective connectivity analysis reveals the existence of two mutual inhibitory systems in patients with major depression Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-18 Jia Wang, Baojuan Li, Jian Liu, Jiaming Li, Adeel Razi, Kaizhong Zheng, Baoyu Yan, Huaning Wang, Hongbing Lu, Karl Friston
It is posited that cognitive and affective dysfunction in patients with major depression disorder (MDD) may be caused by dysfunctional signal propagation in the brain. By leveraging dynamic causal modeling, we investigated large-scale directed signal propagation (effective connectivity) among distributed large-scale brain networks with 43 MDD patients and 56 healthy controls. The results revealed the
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Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change? Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-15 Gengsheng Chen, Nicole S. McKay, Brian A. Gordon, Jingxia Liu, Nelly Joseph-Mathurin, Suzanne E. Schindler, Jason Hassenstab, Andrew J. Aschenbrenner, Qing Wang, Stephanie A. Schultz, Yi Su, Pamela J LaMontagne, Sarah J. Keefe, Parinaz Massoumzadeh, Carlos Cruchaga, Chengjie Xiong, John C. Morris, Tammie L.S. Benzinger
The use of biomarkers for the early detection of Alzheimer’s disease (AD) is crucial for developing potential therapeutic treatments. Positron Emission Tomography (PET) is a well-established tool used to detect β-amyloid (Aβ) plaques in the brain. Previous studies have shown that cross-sectional biomarkers can predict cognitive decline (Schindler et al.,2021). However, it is still unclear whether longitudinal
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Orbitofrontal and striatal metabolism, volume, thickness and structural connectivity in relation to social anhedonia in depression: A multimodal study Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-15 Brianna M. Donnelly, David T. Hsu, John Gardus, Junying Wang, Jie Yang, Ramin V. Parsey, Christine DeLorenzo
Social anhedonia is common within major depressive disorder (MDD) and associated with worse treatment outcomes. The orbitofrontal cortex (OFC) is implicated in both reward (medial OFC) and punishment (lateral OFC) in social decision making. Therefore, to understand the biology of social anhedonia in MDD, medial/lateral OFC metabolism, volume, and thickness, as well as structural connectivity to the
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Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-15 Xiaoxue Shi, Qi Gu, Chang Fu, Jianjun Ma, Dongsheng Li, Jinhua Zheng, Siyuan Chen, Zonghan She, Xuelin Qi, Xue Li, Shaopu Wu, Li Wang
This study was designed to investigate the relationship of irisin with the severity of Parkinson’s disease (PD) and dopamine (DOPA) uptake in patients with PD and to understand the role of irisin in PD. The plasma levels of irisin and α-syn were measured by enzyme-linked immunosorbent assay (ELISA). Motor and nonmotor symptoms were assessed with the relevant scales. DOPA uptake was measured with DOPA
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Cerebral blood flow and white matter alterations in adults with phenylketonuria Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-09 Leonie Steiner, Raphaela Muri, Dilmini Wijesinghe, Kay Jann, Stephanie Maissen-Abgottspon, Piotr Radojewski, Katarzyna Pospieszny, Roland Kreis, Claus Kiefer, Michel Hochuli, Roman Trepp, Regula Everts
Phenylketonuria (PKU) represents a congenital metabolic defect that disrupts the process of converting phenylalanine (Phe) into tyrosine. Earlier investigations have revealed diminished cognitive performance and changes in brain structure and function (including the presence of white matter lesions) among individuals affected by PKU. However, there exists limited understanding regarding cerebral blood
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White matter hyperintensity burden and functional outcomes in acute ischemic stroke patients after mechanical thrombectomy: A systematic review and meta-analysis Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-07 Huanhuan Fan, Lihua Wei, Xiaolin Zhao, Zhiliang Zhu, Wenting Lu, Ramzi Roshani, Kaibin Huang
The influence of white matter hyperintensity (WMH) on clinical outcomes in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT) remains controversial. We performed a systematic review and -analysis to examine whether WMH burden is associated with clinical outcomes in AIS patients after MT. PubMed, Embase, and Web of Science were searched from inception to Sep 03, 2023. The
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Structural connectivity from DTI to predict mild cognitive impairment in de novo Parkinson’s disease Neuroimage Clin. (IF 4.2) Pub Date : 2023-12-02 Xiaofei Huang, Qing He, Xiuhang Ruan, Yuting Li, Zhanyu Kuang, Mengfan Wang, Riyu Guo, Shuwen Bu, Zhaoxiu Wang, Shaode Yu, Amei Chen, Xinhua Wei
Early detection of Parkinson's disease (PD) patients at high risk for mild cognitive impairment (MCI) can help with timely intervention. White matter structural connectivity is considered an early and sensitive indicator of neurodegenerative disease. To investigate whether baseline white matter structural connectivity features from diffusion tensor imaging (DTI) of de novo PD patients can help predict
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Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-21 Zhihan Xu, Minyao Xie, Zhongqi Wang, Haochen Chen, Xuedi Zhang, Wangyue Li, Wenjing Jiang, Na Liu, Ning Zhang
Background Obsessive-compulsive disorder (OCD) is associated with psychosocial impairment, which can be exacerbated by depressive symptoms. In this study, we employed graph theory analysis to investigate the association among neuroimaging, clinical features, and psychosocial functioning in OCD patients, with a specific focus on the differential impact of depressive symptoms. Methods 216 OCD patients
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Rich-club reorganization of white matter structural network in schizophrenia patients with auditory verbal hallucinations following 1 Hz rTMS treatment Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-19 Muzhen Guan, Yuanjun Xie, Chenxi Li, Tian Zhang, Chaozong Ma, Zhongheng Wang, Zhujing Ma, Huaning Wang, Peng Fang
The human brain comprises a large-scale structural network of regions and interregional pathways, including a selectively defined set of highly central and interconnected hub regions, often referred to as the “rich club”, which may play a pivotal role in the integrative processes of the brain. A quintessential symptom of schizophrenia, auditory verbal hallucinations (AVH) have shown a decrease in severity
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Spatial distributions of white matter hyperintensities on brain MRI: A pooled analysis of individual participant data from 11 memory clinic cohorts Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-23 Mirthe Coenen, Geert Jan Biessels, Charles DeCarli, Evan F. Fletcher, Pauline M. Maillard, , Frederik Barkhof, Josephine Barnes, Thomas Benke, Jooske M.F. Boomsma, Christopher P.L.H. Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Nicolai Franzmeier, Onno Groeneveld, Saima Hilal, Hugo J. Kuijf
Introduction The spatial distribution of white matter hyperintensities (WMH) on MRI is often considered in the diagnostic evaluation of patients with cognitive problems. In some patients, clinicians may classify WMH patterns as “unusual”, but this is largely based on expert opinion, because detailed quantitative information about WMH distribution frequencies in a memory clinic setting is lacking. Here
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Functional connectivity of the visual cortex in chronic migraine before and after medication withdrawal therapy Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-17 Veronica Mäki-Marttunen, Dennis A. Kies, Judith A. Pijpers, Mark A. Louter, Nic J. van der Wee, Serge A.R.B. Rombouts, Sander Nieuwenhuis, Mark Kruit, Gisela M. Terwindt
Acute withdrawal of headache medication in chronic migraine patients with medication overuse may lead to a dramatic reduction in headache frequency and severity. However, the brain networks underlying chronic migraine and a favorable response to acute withdrawal are still poorly understood. The goal of the present study was to characterize the pattern of intrinsic magnetic resonance imaging (MRI) functional
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Motor networks, but also non-motor networks predict motor signs in Parkinson’s disease Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-11 Anjanibhargavi Ragothaman, Martina Mancini, John G. Nutt, Junping Wang, Damien A. Fair, Fay B. Horak, Oscar Miranda-Dominguez
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A deep learning analysis of stroke onset time prediction and comparison to DWI-FLAIR mismatch Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-16 Ela Marie Z. Akay, Jana Rieger, Ricardo Schöttler, Jonas Behland, Raphael Schymczyk, Ahmed A. Khalil, Ivana Galinovic, Jan Sobesky, Jochen B. Fiebach, Vince I. Madai, Adam Hilbert, Dietmar Frey
Introduction When time since stroke onset is unknown, DWI-FLAIR mismatch rating is an established technique for patient stratification. A visible DWI lesion without corresponding parenchymal hyperintensity on FLAIR suggests time since onset of under 4.5 h and thus a potential benefit from intravenous thrombolysis. To improve accuracy and availability of the mismatch concept, deep learning might be
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Brain microstate spatio-temporal dynamics as a candidate endotype of consciousness Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-16 Piergiuseppe Liuzzi, Andrea Mannini, Bahia Hakiki, Silvia Campagnini, Anna Maria Romoli, Francesca Draghi, Rachele Burali, Maenia Scarpino, Francesca Cecchi, Antonello Grippo
Consciousness can be defined as a phenomenological experience continuously evolving. Current research showed how conscious mental activity can be subdivided into a series of atomic brain states converging to a discrete spatiotemporal pattern of global neuronal firing. Using the high temporal resolution of EEG recordings in patients with a severe Acquired Brain Injury (sABI) admitted to an Intensive
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Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-13 Julia E. Werhahn, Lukasz Smigielski, Seda Sacu, Susanna Mohl, David Willinger, Jilly Naaijen, Leandra M. Mulder, Jeffrey C. Glennon, Pieter J. Hoekstra, Andrea Dietrich, Renee Kleine Deters, Pascal M. Aggensteiner, Nathalie E. Holz, Sarah Baumeister, Tobias Banaschewski, Melanie C. Saam, Ulrike M.E. Schulze, David J. Lythgoe, Arjun Sethi, Michael Craig, Daniel Brandeis
Background Disruptive behavior in children and adolescents can manifest as reactive aggression and proactive aggression and is modulated by callous-unemotional traits and other comorbidities. Neural correlates of these aggression dimensions or subtypes and comorbid symptoms remain largely unknown. This multi-center study investigated the relationship between resting state functional connectivity (rsFC)
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Longitudinal alterations in cerebral perfusion following a season of adolescent contact sport participation compared to non-contact athletes Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-09 Benjamin L. Brett, Alex D. Cohen, Michael A. McCrea, Yang Wang
Background Cerebral blood flow (CBF) change, a non-invasive marker of head injury, has yet to be thoroughly investigated as a potential consequence of repetitive head impacts (RHI) via contact sport participation in youth athletes. We examined pre-to post-season differences in relative CBF (rCBF), arterial transit time (ATT), and neurocognition between adolescent contact sport (CS; 79.4% of which were
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Functional MRI correlates of emotion regulation in major depressive disorder related to depressive disease load measured over nine years Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-11 Rozemarijn S. van Kleef, Amke Müller, Laura S. van Velzen, Janna Marie Bas-Hoogendam, Nic J.A. van der Wee, Lianne Schmaal, Dick J. Veltman, Maria M. Rive, Henricus G. Ruhé, Jan-Bernard C. Marsman, Marie-José van Tol
Major Depressive Disorder (MDD) often is a recurrent and chronic disorder. We investigated the neurocognitive underpinnings of the incremental risk for poor disease course by exploring relations between enduring depression and brain functioning during regulation of negative and positive emotions using cognitive reappraisal. We used fMRI-data from the longitudinal Netherlands Study of Depression and
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Testing the triple network model of psychopathology in a transdiagnostic neurodevelopmental cohort Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-09 Jonathan S. Jones, Alicja Monaghan, Amelia Leyland-Craggs, , Duncan E. Astle
Aim The triple network model of psychopathology posits that altered connectivity between the Salience (SN), Central Executive (CEN), and Default Mode Networks (DMN) may underlie neurodevelopmental conditions. However, this has yet to be tested in a transdiagnostic sample of young people. Method We investigated this in 175 children (60 girls) that represent a heterogeneous population who are experiencing
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Predicting treatment response in adolescents and young adults with major depressive episodes from fMRI using graph isomorphism network Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-04 Jia Duan, Yueying Li, Xiaotong Zhang, Shuai Dong, Pengfei Zhao, Jie Liu, Junjie Zheng, Rongxin Zhu, Youyong Kong, Fei Wang
Background Major depressive episode (MDE) is the main clinical feature of mood disorders (major depressive disorder and bipolar disorder) in adolescents and young adults and accounts for most of the disease course. However, 30%-40% of MDE patients not responding to clinical first-line interventions. It is crucial to predict treatment response in the early stages and identify biomarkers associated with
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Detecting conversion from mild cognitive impairment to Alzheimer’s disease using FLAIR MRI biomarkers Neuroimage Clin. (IF 4.2) Pub Date : 2023-11-03 Owen Crystal, Pejman J. Maralani, Sandra Black, Corinne Fischer, Alan R. Moody, April Khademi
Mild cognitive impairment (MCI) is the prodromal phase of Alzheimer’s disease (AD) and while it presents as an imperative intervention window, it is difficult to detect which subjects convert to AD (cMCI) and which ones remain stable (sMCI). The objective of this work was to investigate fluid-attenuated inversion recovery (FLAIR) MRI biomarkers and their ability to differentiate between sMCI and cMCI