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Astrocytic phagocytosis in the medial prefrontal cortex jeopardises postoperative memory consolidation in mice Brain Pathol. (IF 6.4) Pub Date : 2024-03-08 Xin Ma, Yuan Le, Lin Hu, Wen Ouyang, Cheng Li, Daqing Ma, Jianbin Tong
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Neuropathological stage‐dependent proteome mapping of the olfactory tract in Alzheimer's disease: From early olfactory‐related omics signatures to computational repurposing of drug candidates Brain Pathol. (IF 6.4) Pub Date : 2024-03-08 Paz Cartas‐Cejudo, Adriana Cortés, Mercedes Lachén‐Montes, Elena Anaya‐Cubero, Elena Puerta, Maite Solas, Joaquín Fernández‐Irigoyen, Enrique Santamaría
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Dysregulation of the renin‐angiotensin system in vascular dementia Brain Pathol. (IF 6.4) Pub Date : 2024-03-08 H. M. Tayler, O. A. Skrobot, D. H. Baron, P. G. Kehoe, J. S. Miners
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Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights Brain Pathol. (IF 6.4) Pub Date : 2024-02-28 Sergio Pérez-Oliveira, Juan Castilla-Silgado, Cèlia Painous, Iban Aldecoa, Manuel Menéndez-González, Marta Blázquez-Estrada, Daniela Corte, Cristina Tomás-Zapico, Yaroslau Compta, Esteban Muñoz, Albert Lladó, Mircea Balasa, Gemma Aragonès, Pablo García-González, Maitée Rosende-Roca, Mercè Boada, Agustín Ruíz, Pau Pastor, Beatriz De la Casa-Fages, Alberto Rabano, Raquel Sánchez-Valle, Laura Molina-Porcel
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Meeting report of the 20th International Congress of Neuropathology (ICN) 2023 in Berlin Brain Pathol. (IF 6.4) Pub Date : 2024-02-28 Hans H. Goebel, Arend Koch, Helena Radbruch, Simone Schmid, Ekaterina Friebel, Werner Stenzel, Frank L. Heppner, David Capper
1 INTRODUCTION AND PROLOGUE Exactly 62 years to the month after the 4th International Congress of Neuropathology (ICN) took place from September 4th to 8th 1961 at the Ludwig Maximilian University of Munich, the global neuropathological community—or, more accurately, its neuropathological children and grandchildren—returned back to the 20th ICN, that is, ICN2023, in Berlin/Germany (12–16 September
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Ranking and filtering of neuropathology features in the machine learning evaluation of dementia studies Brain Pathol. (IF 6.4) Pub Date : 2024-02-19 Mohammed D. Rajab, Teruka Taketa, Stephen B. Wharton, Dennis Wang
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A 7-year-old boy presented with temporal lobe lesion Brain Pathol. (IF 6.4) Pub Date : 2024-02-14 Manli Zhao, Tingting Huang, Xueping Xiang, Yang Liu, Weizhong Gu, Lei Liu, Hongfeng Tang, Jinghong Xu, Jianhua Mao
1 CLINICAL HISTORY A previously healthy 7-year-old boy presented with generalized tonic-clonic seizures for approximately 1 month. He was the first child of unrelated, healthy parents and had exhibited normal development. MR imaging demonstrated a large, right-sided temporal lobe mass-like lesion measuring 44 × 25 × 24 mm. The lesion exhibited hypointense on T1-weighted images and a distinct heterogenous
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Astrocyte-derived Interleukin-31 causes poor prognosis in elderly patients with intracerebral hemorrhage Brain Pathol. (IF 6.4) Pub Date : 2024-02-14 Rui Jiang, Zhichao Lu, Chenxing Wang, WenJun Tu, Qi Yao, Jiabing Shen, Xingjia Zhu, Ziheng Wang, Yixun Chen, Yang Yang, Kaijiang Kang, Peipei Gong
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A 24-year-old woman with a recurrent intracranial mass Brain Pathol. (IF 6.4) Pub Date : 2024-02-05 Yan Peng, Wei Zhao, Dachuan Zhang, Xie Gao, Yongqiang Shi, Qing Li, Jian Wang
BOX 1. Virtual glass slide Access at https://isn-slidearchive.org/?col=ISN&fol=Archive&file=BPA-23-06-CI-158-primary.svs
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Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage Brain Pathol. (IF 6.4) Pub Date : 2024-02-02 Chien-Cheng Chen, Chia-Hua Ke, Chun-Hu Wu, Hung-Fu Lee, Yuan Chao, Min-Chien Tsai, Song-Kun Shyue, Szu-Fu Chen
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The relation between BTK expression and iron accumulation of myeloid cells in multiple sclerosis Brain Pathol. (IF 6.4) Pub Date : 2024-01-22 Anja Steinmaurer, Christian Riedl, Theresa König, Giulia Testa, Ulrike Köck, Jan Bauer, Hans Lassmann, Romana Höftberger, Thomas Berger, Isabella Wimmer, Simon Hametner
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Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells Brain Pathol. (IF 6.4) Pub Date : 2024-01-22 Veronica Astillero-Lopez, Sandra Villar-Conde, Melania Gonzalez-Rodriguez, Alicia Flores-Cuadrado, Isabel Ubeda-Banon, Daniel Saiz-Sanchez, Alino Martinez-Marcos
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Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer's disease and frontotemporal dementia Brain Pathol. (IF 6.4) Pub Date : 2024-01-21 Julie J. McInvale, Peter Canoll, Gunnar Hargus
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Diagnostic utility of genetic alterations in distinguishing IDH-wildtype glioblastoma from lower-grade gliomas: Insight from next-generation sequencing analysis of 479 cases Brain Pathol. (IF 6.4) Pub Date : 2024-01-12 Boram Lee, Soohyun Hwang, Hyunsik Bae, Kyue-Hee Choi, Yeon-Lim Suh
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Understanding the pathogenic mechanisms and therapeutic effects in neurocysticercosis Brain Pathol. (IF 6.4) Pub Date : 2024-01-11 Gino Castillo, Lizbeth Fustamante, Ana D. Delgado-Kamiche, Rogger P. Camen-Orozco, Taryn Clark, Edson Bernal, Jemima Morales-Alvarez, Maria Ferrufino, Javier Mamani-Palomino, Javier A. Bustos, Hector H. Garcia, Cesar M. Gavidia, Robert H. Gilman, Manuela Verastegui
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Morphology-based molecular classification of spinal cord ependymomas using deep neural networks Brain Pathol. (IF 6.4) Pub Date : 2024-01-11 Yannis Schumann, Matthias Dottermusch, Leonille Schweizer, Maja Krech, Tasja Lempertz, Ulrich Schüller, Philipp Neumann, Julia E. Neumann
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The post-stroke young adult brain has limited capacity to re-express the gene expression patterns seen during early postnatal brain development Brain Pathol. (IF 6.4) Pub Date : 2024-01-10 Mihai Ruscu, Bogdan Capitanescu, Paul Rupek, Thomas Dandekar, Eugen Radu, Dirk M. Hermann, Aurel Popa-Wagner
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Phenotype parallels protein seeding capacity in neurodegenerative diseases Brain Pathol. (IF 6.4) Pub Date : 2024-01-12 Ivan Martinez-Valbuena
With the new era of disease-modifying therapies for neurodegenerative diseases, a novel approach for the molecular classification of neurodegenerative diseases is needed. In this research letter, there is a summary of the advances made in Alzheimer's disease, Lewy body disorders, and progressive supranuclear palsy toward this classification.
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Refinement of prognostication for IDH-mutant astrocytomas using DNA methylation-based classification Brain Pathol. (IF 6.4) Pub Date : 2024-01-02 Teresia Kling, Sandra Ferreyra Vega, Medha Suman, Anna Dénes, Anna Lipatnikova, Stina Lagerström, Thomas Olsson Bontell, Asgeir Store Jakola, Helena Carén
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Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia Brain Pathol. (IF 6.4) Pub Date : 2023-12-19 Laura R. Nementzik, Kyrah M. Thumbadoo, Helen C. Murray, David Gordon, Shu Yang, Ian P. Blair, Clinton Turner, Richard L. M. Faull, Maurice A. Curtis, Catriona McLean, Garth A. Nicholson, Molly E. V. Swanson, Emma L. Scotter
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Acknowledgement to Reviewers Brain Pathol. (IF 6.4) Pub Date : 2023-12-10
Each year hundreds of reviewers contribute their expertise to peer review, a process that contributes critically to the quality of the Brain Pathology. The editors at Brain Pathology would like to extend their gratitude to those who have provided their time and energy to review manuscripts for our journal over the last year. We are well aware that our journal can only exist thanks to your concerted
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A 63-year-old woman with parietal scalp surface rugged Brain Pathol. (IF 6.4) Pub Date : 2023-12-06 Zhiwei Shen, Siqi Tao
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Structural changes of CA1 pyramidal neurons after stroke in the contralesional hippocampus Brain Pathol. (IF 6.4) Pub Date : 2023-11-27 Paula Merino-Serrais, Sergio Plaza-Alonso, Farida Hellal, Susana Valero-Freitag, Asta Kastanauskaite, Nikolaus Plesnila, Javier DeFelipe
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DistSNE: Distributed computing and online visualization of DNA methylation-based central nervous system tumor classification Brain Pathol. (IF 6.4) Pub Date : 2023-11-27 Kai Schmid, Jannik Sehring, Attila Németh, Patrick N. Harter, Katharina J. Weber, Abishaa Vengadeswaran, Holger Storf, Christian Seidemann, Kapil Karki, Patrick Fischer, Hildegard Dohmen, Carmen Selignow, Andreas von Deimling, Stefan Grau, Uwe Schröder, Karl H. Plate, Marco Stein, Eberhard Uhl, Till Acker, Daniel Amsel
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Reduced neurogenesis in human hippocampus with Alzheimer's disease Brain Pathol. (IF 6.4) Pub Date : 2023-11-27 Yan Cao, Pan Liu, Hongfei Bian, Sixuan Jin, Jiaqi Liu, Ning Yu, Huan Cui, Fengrun Sun, Xiaojing Qian, Wenying Qiu, Chao Ma
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Primary visual cortex pathology in ALS patients with C9ORF72 expansion Brain Pathol. (IF 6.4) Pub Date : 2023-11-27 Matthew D. Cykowski, Anithachristy S. Arumanayagam, Suzanne Z. Powell, Stanley H. Appel
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Two novel tumours with NTRK2 fusion in the methylation class of extraventricular neurocytomas, including one intraventricular Brain Pathol. (IF 6.4) Pub Date : 2023-11-23 Emmanuelle Uro-Coste, Arnault Tauziede-Espariat, Charlotte Dubucs, Dan Christian Chiforeanu, Aurore Siegfried, Yvan Nicaise, Luc Bauchet, Laurent Riffaud, Franck Bielle, Alexandre Vasiljevic, Romain Appay, Solène Evrard, Pascale Varlet, Valérie Rigau
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Degeneration of olivospinal tract in the upper cervical spinal cord of multiple system atrophy patients: Reappraisal of Helweg's triangular tract Brain Pathol. (IF 6.4) Pub Date : 2023-11-16 Takashi Ando, Yuichi Riku, Akio Akagi, Hiroaki Miyahara, Takashi Uematsu, Ikuko Aiba, Jun Sone, Masahisa Katsuno, Mari Yoshida, Yasushi Iwasaki
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Concomitant progressive supranuclear palsy and Lewy body pathology presenting with circumscribed visual memory loss: A clinicopathological case Brain Pathol. (IF 6.4) Pub Date : 2023-11-05 Christopher Kobylecki, Jennifer C. Thompson, Andrew C. Robinson, Federico Roncaroli, Julie S. Snowden, David M. Mann
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Automated analysis of gray matter damage in aged mice reveals impaired remyelination in the cuprizone model Brain Pathol. (IF 6.4) Pub Date : 2023-11-05 Stefan Gingele, Thiemo M. Möllenkamp, Florian Henkel, Lara-Jasmin Schröder, Martin W. Hümmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi
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Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice Brain Pathol. (IF 6.4) Pub Date : 2023-10-30 Moon Yi Ko, Heejin Park, Sun-Hwa Chon, Byoung-Seok Lee, Sin-Woo Cha, Sung-Ae Hyun, Minhan Ka
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SPI1 activates TGF-β1/PI3K/Akt signaling through transcriptional upregulation of FKBP12 to support the mesenchymal phenotype of glioma stem cells Brain Pathol. (IF 6.4) Pub Date : 2023-10-22 Yifu Song, Yaochuan Zhang, Xiaoliang Wang, Xiaodi Han, Mengwu Shi, Ling Xu, Juanhan Yu, Li Zhang, Sheng Han
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Poly-GA immunohistochemistry is a reliable tool for detecting C9orf72 hexanucleotide repeat expansions Brain Pathol. (IF 6.4) Pub Date : 2023-10-10 Jordan Carroll, Heather McCann, Glenda M. Halliday, John B. Kwok, Carol Dobson-Stone, Claire E. Shepherd
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LATE-NC in Alzheimer's disease: Molecular aspects and synergies Brain Pathol. (IF 6.4) Pub Date : 2023-10-04 Sandra O. Tomé, Klara Gawor, Dietmar Rudolf Thal
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Colocalization of TDP-43 and stress granules at the early stage of TDP-43 aggregation in amyotrophic lateral sclerosis Brain Pathol. (IF 6.4) Pub Date : 2023-10-04 Fumiaki Mori, Hina Yasui, Yasuo Miki, Tomoya Kon, Akira Arai, Hidekachi Kurotaki, Masahiko Tomiyama, Koichi Wakabayashi
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Enhanced Creutzfeldt-Jakob disease surveillance in the older population: Assessment of a protocol for screening brain tissue donations for prion disease Brain Pathol. (IF 6.4) Pub Date : 2023-09-28 Alexander H. Peden, Adriana Libori, Diane L. Ritchie, Helen Yull, Colin Smith, Lovney Kanguru, Anna Molesworth, Richard Knight, Marcelo A. Barria
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Tumor-associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin-2 Brain Pathol. (IF 6.4) Pub Date : 2023-09-18 Haishuang Li, Yuqing Liu, Yantao Liu, Luzheng Xu, Ziwen Sun, Danfeng Zheng, Xiaodan Liu, Chen Song, Yu Zhang, Hui Liang, Bao Yang, Xinxia Tian, Jianyuan Luo, Qing Chang
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Frontal lobe mass in a 46-year-old woman Brain Pathol. (IF 6.4) Pub Date : 2023-09-15 Kevin Y. Zhang, Bharat Ramlal, Karisa C. Schreck, Charles G. Eberhart, Calixto-Hope G. Lucas
1 CLINICAL HISTORY A 46-year-old woman presented with new onset seizures. Magnetic resonance imaging (MRI) revealed a 4 cm heterogeneously enhancing mass centered in the right posterior frontal lobe with mild perilesional edema and effacement of the adjacent sulci (Figure 1A). The mass was restricted to cortex and hemispheric white matter, with no involvement of deep grey matter or other midline structures
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Abstracts of the 20th International Congress of Neuropathology Berlin, Germany, September 13 - 16, 2023. Brain Pathol. (IF 6.4) Pub Date : 2023-09-01
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The molecular spectrum of amyloid-beta (Aβ) in neurodegenerative diseases beyond Alzheimer's disease Brain Pathol. (IF 6.4) Pub Date : 2023-08-31 Shojiro Ichimata, Koji Yoshida, Jun Li, Ekaterina Rogaeva, Anthony E. Lang, Gabor G. Kovacs
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Honing in on magnetic resonance imaging predictors of multiple sclerosis pathology Brain Pathol. (IF 6.4) Pub Date : 2023-08-30 Klaus Schmierer
As our understanding of the mechanisms leading to tissue damage and repair in multiple sclerosis (MS) evolves, so does our desire to detect and monitor their structural and functional correlates in people with this chronic disease during life. Given the heterogeneous nature of the tissue injury in MS, in terms of severity and timing, this is of significant interest for (i) the management of people
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Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele Brain Pathol. (IF 6.4) Pub Date : 2023-08-30 Xiao-Yu Ji, Xin-Yuan Peng, Hai-Liang Tang, Hui Pan, Wei-Tang Wang, Jie Wu, Jian Chen, Nai-Li Wei
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Lipid metabolism and oxidative stress in patients with Alzheimer's disease and amnestic mild cognitive impairment Brain Pathol. (IF 6.4) Pub Date : 2023-08-24 Yuting Nie, Changbiao Chu, Qi Qin, Huixin Shen, Lulu Wen, Yi Tang, Miao Qu
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Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis Brain Pathol. (IF 6.4) Pub Date : 2023-08-16 Hiroyuki Honda, Kaoru Yagita, Hajime Arahata, Hideomi Hamasaki, Hideko Noguchi, Sachiko Koyama, Naokazu Sasagasako
FUS mutations are one of the major mutations in familial amyotrophic lateral sclerosis (ALS). The pathological hallmark is FUS-positive neuronal cytoplasmic inclusions (FUS-NCI), known as FUS proteinopathy. Human myxovirus resistance protein 1 (MxA) is an IFN-induced dynamin-like GTPase that acts as antiviral factor. In this study, we examined the expression of MxA in neurons bearing FUS-NCI. We performed
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Myelin protein zero mutation-related hereditary neuropathies: Neuropathological insight from a new nerve biopsy cohort Brain Pathol. (IF 6.4) Pub Date : 2023-08-15 Juliane Bremer, Axel Meinhardt, Istvan Katona, Jan Senderek, Elke K. Kämmerer-Gassler, Andreas Roos, Andreas Ferbert, J. Michael Schröder, Stefan Nikolin, Kay Nolte, Bernd Sellhaus, Klimentina Popzhelyazkova, Frank Tacke, Ulrike Schara-Schmidt, Eva Neuen-Jacob, Chantal Ceuterick de Groote, Peter de Jonghe, Vincent Timmerman, Jonathan Baets, Joachim Weis
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IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated amyotrophic lateral sclerosis Brain Pathol. (IF 6.4) Pub Date : 2023-08-15 Amanda Faria Assoni, Erika N. Guerrero, René Wardenaar, Danyllo Oliveira, Petra L. Bakker, Luciana M. Alves, Valdemir M. Carvalho, Oswaldo Keith Okamoto, Mayana Zatz, Floris Foijer
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Announcing the Asian Oceanian Society of Neuropathology guidelines for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR) Brain Pathol. (IF 6.4) Pub Date : 2023-08-13 M. E. Buckland, C. Sarkar, V. Santosh, M. Al-Hussaini, S. H. Park, T. Tihan, H. K. Ng, T. Komori
In 2023, molecular evaluation contributes significantly to classifying many central nervous system (CNS) tumors and offers prognostic and predictive information [1]. Following the WHO 2016 [2], the 2021 WHO classification (WHO CNS5) further advanced the integration of molecular diagnostics into CNS tumor diagnosis and grading [3]. Methylation profiling is now also recognized as a powerful molecular
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Exploiting nanopore sequencing for characterization and grading of IDH-mutant gliomas Brain Pathol. (IF 6.4) Pub Date : 2023-08-13 Thidathip Wongsurawat, Piroon Jenjaroenpun, Panatna Anekwiang, Tantip Arigul, Wichayapat Thongrattana, Azemat Jamshidi-Parsian, Gunnar Boysen, Prapat Suriyaphol, Bhoom Suktitipat, Prajak Srirabheebhat, Pornsuk Cheunsuchon, Jantima Tanboon, Intawat Nookaew, Sith Sathornsumetee
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Postmortem neuropathology in COVID-19: An update Brain Pathol. (IF 6.4) Pub Date : 2023-08-11 David S. Younger
Between 2020 and 2021, Younger [1, 2] described the neuropathology of 144 decedents due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) at the height of the 2019 coronavirus-2 (COVID-19) pandemic. The present study concerns an updated later cohort adding 150 new cases [3-20]. There was a modest demographic shift in the updated later cohort. The study population comprised 12 children
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Evaluating the performance of large language models: ChatGPT and Google Bard in generating differential diagnoses in clinicopathological conferences of neurodegenerative disorders. Brain Pathol. (IF 6.4) Pub Date : 2023-08-08 Shunsuke Koga,Nicholas B Martin,Dennis W Dickson
This study explores the utility of the large language models (LLMs), specifically ChatGPT and Google Bard, in predicting neuropathologic diagnoses from clinical summaries. A total of 25 cases of neurodegenerative disorders presented at Mayo Clinic brain bank Clinico-Pathological Conferences were analyzed. The LLMs provided multiple pathologic diagnoses and their rationales, which were compared with
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Age-related hearing loss and dementia-related neuropathology: An analysis of the United Kingdom brains for dementia research cohort Brain Pathol. (IF 6.4) Pub Date : 2023-08-08 Jessica A. Katanga, Calum A. Hamilton, Lauren Walker, Johannes Attems, Alan J. Thomas
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Peripheral macrophages drive CNS disease in the Ndufs4(−/−) model of Leigh syndrome Brain Pathol. (IF 6.4) Pub Date : 2023-08-08 Allison R. Hanaford, Asheema Khanna, Vivian Truong, Katerina James, Yihan Chen, Michael Mulholland, Bernhard Kayser, Ryan W. Liao, Margaret Sedensky, Phil Morgan, Nathan Andrew Baertsch, Vandana Kalia, Surojit Sarkar, Simon C. Johnson
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MET fusions and splicing variants is a strong adverse prognostic factor in astrocytoma, isocitrate dehydrogenase mutant Brain Pathol. (IF 6.4) Pub Date : 2023-08-02 Lingyu Liu, Ke-Nan Zhang, Zheng Zhao, Guanzhang Li, Rui-Chao Chai, Zhuoqun Li, Xing Liu, Jing Chen, Tao Jiang
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Neuropathological hallmarks in autopsied cases with mitochondrial diseases caused by the mitochondrial 3243A>G mutation Brain Pathol. (IF 6.4) Pub Date : 2023-08-03 Hiroaki Miyahara, Chisato Tamai, Masanori Inoue, Kazuhito Sekiguchi, Daisuke Tahara, Nao Tahara, Kazuhiro Takeda, Shusei Arafuka, Hideyuki Moriyoshi, Ryuichi Koizumi, Akio Akagi, Yuichi Riku, Jun Sone, Mari Yoshida, Kenji Ihara, Yasushi Iwasaki
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Altered properties of amyloidogenic prion protein in genetic Creutzfeldt–Jakob disease with PRNP V180I mutation in response to pentosan polysulfate Brain Pathol. (IF 6.4) Pub Date : 2023-07-31 Masahiro Shijo, Motoi Yoshimura, Tsuyoshi Omae, Go Hashimoto, Tadataka Mizoguchi, Takahiro Kuwashiro, Takashi Komori, Yoshio Tsuboi, Tomoko Saito, Masanori Nakagawa, Kyoko Itoh, Hiroyuki Honda
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Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis Brain Pathol. (IF 6.4) Pub Date : 2023-07-28 Upasana Maheshwari, José M. Mateos, Ulrike Weber-Stadlbauer, Ruiqing Ni, Virgil Tamatey, Sucheta Sridhar, Alejandro Restrepo, Pim A. de Jong, Sheng-Fu Huang, Johanna Schaffenrath, Sebastian A. Stifter, Flora Szeri, Melanie Greter, Huiberdina L. Koek, Annika Keller
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Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain Brain Pathol. (IF 6.4) Pub Date : 2023-07-24 Shuyu Zhang, Karina Dauer, Timo Strohäker, Lars Tatenhorst, Lucas Caldi Gomes, Simon Mayer, Byung Chul Jung, Woojin S. Kim, Seung-Jae Lee, Stefan Becker, Friederike Liesche-Starnecker, Markus Zweckstetter, Paul Lingor
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Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ42, phosphorylated α-synuclein, and synaptopathology Brain Pathol. (IF 6.4) Pub Date : 2023-07-18 Joyce R. Chong, Yuek Ling Chai, Huayang Xing, Deron R. Herr, Markus R. Wenk, Paul T. Francis, Clive Ballard, Dag Aarsland, David L. Silver, Christopher P. Chen, Amaury Cazenave-Gassiot, Mitchell K. P. Lai
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A vade mecum for crossing the second translational “valley of death” in brain tumor classification Brain Pathol. (IF 6.4) Pub Date : 2023-07-06 David N. Louis
The road from a basic research discovery to widespread clinical implementation can be long. The journey has been said to involve three peaks and two intervening valleys (Figure 1) [4]. The first peak is the initial scientific discovery, typically made in a research laboratory and lacking immediate clinical significance. The second peak is the realization that a new scientific fact has clear medical
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A diffuse glioma with oligodendroglial-like cells and extensive calcifications Brain Pathol. (IF 6.4) Pub Date : 2023-07-06 Filippo Maria Martelli, Elena Marastoni, Valeria Barresi