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Cognitive Profile in Parkinson's Disease Dementia Patients with Low versus Normal Cerebrospinal Fluid Amyloid Beta. Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2023-10-26 Zeynep Tufekcioglu,Johannes Lange,Kenn Freddy Pedersen,Ole-Bjørn Tysnes,Guido Alves,Murat Emre
Introduction In patients with Parkinson's disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, however, a typical hallmark of Alzheimer's disease (AD). Hence, low CSF Ab42 in patients with PD may indicate presence of comorbid AD pathology and may predict a more AD-like cognitive
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Artificial Intelligence for Detection of Dementia Using Motion Data: A Scoping Review. Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2023-09-13 Lily Puterman-Salzman,Jory Katz,Howard Bergman,Roland Grad,Vladimir Khanassov,Genevieve Gore,Isabelle Vedel,Machelle Wilchesky,Narges Armanfard,Negar Ghourchian,Samira Abbasgholizadeh Rahimi
Background Dementia is a neurodegenerative disease resulting in the loss of cognitive and psychological functions. Artificial intelligence (AI) may help in detection and screening of dementia; however, little is known in this area. Objectives The objective of this study was to identify and evaluate AI interventions for detection of dementia using motion data. Method The review followed the framework
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Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients. Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2023-08-02 Jedsada Khieukhajee,Arada Rojana-Udomsart,Pinnakarn Srisarakorn,Tanaphon Wongsurit,Saharat Aungsumart
Introduction Numerous reports regarding cognitive deficits after the coronavirus disease 2019 (COVID-19), described as "brain fog," have been published. However, the clinical presentations and risk factors of post-COVID-19 cognitive impairment are controversial. This study aimed to assess (a) the prevalence of cognitive impairment after COVID-19 hospitalization, (b) characteristics of the cognitive
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An Online Version of Physical Exercise with Musical Accompaniment Might Facilitate Participation by Subjects Who Cannot Participate in Person: A Questionnaire-Based Study. Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2023-05-31 Masayuki Satoh,Ken-Ichi Tabei,Jun-Ichi Ogawa,Makiko Abe,Chiaki Kamikawa,Yoshinori Ota
Introduction Due to the ongoing outbreak of the coronavirus disease 2019 (COVID-19), it is currently difficult to conduct in-person exercise classes. We thus started the program of an online physical exercise with musical accompaniment. Several interesting differences were found in the characteristics of the online participants compared with our previous in-person interventions. Participants and Methods
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Relationship between Cognitive Decline and Daily Life Gait among Elderly People Living in the Community: A Preliminary Report Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2023-03-02 Tetsuya Yamagami, Motoi Yagi, Shigeya Tanaka, Saori Anzai, Takuya Ueda, Yoshitsugu Omori, Chika Tanaka, Yoshitaka Shiba
Introduction: Early detection and intervention are important to prevent dementia. Gait parameters have been recognized as a potentially easy screening tool for mild cognitive impairment (MCI); however, differences in gait parameters between cognitive healthy individuals (CHI) and MCI are small. Daily life gait change may be used to detect cognitive decline earlier. In the present study, we aimed to
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Structured Pre-Consultation Interview at the First Call of Caregiver Regarding Memory Consultation: Effects on Caregiver Burden, Expectations, and Quality of Life Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-11-28 Isabelle Guillard, Florence Saillour, Aurélie Lafargue, Fabien Salesses, Claire Roubaud Baudron, Valérie Berger, Isabelle Bourdel-Marchasson
Introduction: Case managers can guide caregivers during their search for care for relatives with neurocognitive disorders. The present study aimed to evaluate the effects of this procedure on caregiver burden and quality of life. Methods: Family caregivers searching for care at a memory clinic before the first consultation were provided written information and they provided verbal consent to participate
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Structured Pre-Consultation Interview at the First Call of Caregiver Regarding Memory Consultation: Effects on Caregiver Burden, Expectations, and Quality of Life Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-11-28
Introduction: Case managers can guide caregivers during their search for care for relatives with neurocognitive disorders. The present study aimed to evaluate the effects of this procedure on caregiver burden and quality of life. Methods: Family caregivers searching for care at a memory clinic before the first consultation were provided written information and they provided verbal consent to participate
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Comparing the Working Memory Capacity with Cognitive Flexibility, Cognitive Emotion Regulation, and Learning Styles of University Students: A Domain General View Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-11-14 Kahraman Guler, Aylin Aydin
Introduction: The goal of this study was to investigate the relationship of working memory capacity with the use of cognitive emotion regulation strategies, cognitive flexibility level, and learning styles of university students. Methods: In the present study (N = 39), the participants completed the Emotion Regulation Questionnaire, Cognitive Flexibility Scale, Kolb Learning Styles Inventory, and Vermunt
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Comparing the Working Memory Capacity with Cognitive Flexibility, Cognitive Emotion Regulation, and Learning Styles of University Students: A Domain General View Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-11-14
Introduction: The goal of this study was to investigate the relationship of working memory capacity with the use of cognitive emotion regulation strategies, cognitive flexibility level, and learning styles of university students. Methods: In the present study (N = 39), the participants completed the Emotion Regulation Questionnaire, Cognitive Flexibility Scale, Kolb Learning Styles Inventory, and Vermunt
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Clinical Features of Patients with Alzheimer’s Disease and a History of Traumatic Brain Injury Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-09-16 Suzan van Amerongen, Dewi K. Caton, Yolande A.L. Pijnenburg, Philip Scheltens, Everard G.B. Vijverberg
Introduction: Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer’s disease (AD). Less is known about the clinical features of AD patients with TBI history. The objective of this study was to examine whether a history of TBI and specific injury characteristics are associated with differences in age of disease onset, cognitive features, and neuropsychiatric symptoms
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Clinical Features of Patients with Alzheimer’s Disease and a History of Traumatic Brain Injury Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-09-16
Introduction: Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer’s disease (AD). Less is known about the clinical features of AD patients with TBI history. The objective of this study was to examine whether a history of TBI and specific injury characteristics are associated with differences in age of disease onset, cognitive features, and neuropsychiatric symptoms
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Nurses’ Pain Assessment Practices for Cognitively Intact and Impaired Older Adults in Intensive Care Units Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-07-04 Mohammad Rababa, Shatha Al-Sabbah
Introduction: Pain is still under-recognized and undertreated among intensive care unit (ICU) patients, such as those being intubated or with dementia, cognitive impairments, or communication deficits due to inability to self-report. This study aimed to describe nurses’ pain assessment practices for cognitively intact and impaired older adult ICU patients. Methods: A descriptive correlational study
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Nurses’ Pain Assessment Practices for Cognitively Intact and Impaired Older Adults in Intensive Care Units Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-07-04
Introduction: Pain is still under-recognized and undertreated among intensive care unit (ICU) patients, such as those being intubated or with dementia, cognitive impairments, or communication deficits due to inability to self-report. This study aimed to describe nurses’ pain assessment practices for cognitively intact and impaired older adult ICU patients. Methods: A descriptive correlational study
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Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-06-23 Maria Lage Barca, Dag Alnæs, Knut Engedal, Karin Persson, Rannveig Sakshaug Eldholm, Nikias Siafarikas, Ina Selseth Almdahl, Maria Stylianou-Korsnes, Ingvild Saltvedt, Geir Selbæk, Lars T. Westlye
Introduction: Findings regarding brain morphometry among patients with dementia and concomitant depressive symptoms have been inconsistent. Thus, the aim of the present study was to test the hypothesis that dementia and concomitant depressive symptoms are associated with structural brain changes in the temporal lobe measured with structural magnetic resonance imaging (MRI). Methods: A sample of 492
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Brain Morphometric Correlates of Depressive Symptoms among Patients with and without Dementia Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-06-23
Introduction: Findings regarding brain morphometry among patients with dementia and concomitant depressive symptoms have been inconsistent. Thus, the aim of the present study was to test the hypothesis that dementia and concomitant depressive symptoms are associated with structural brain changes in the temporal lobe measured with structural magnetic resonance imaging (MRI). Methods: A sample of 492
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The Effect of the Ketogenic Diet on the Therapy of Neurodegenerative Diseases and Its Impact on Improving Cognitive Functions Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-30 Klaudia Grochowska, Anna Przeliorz
The ketogenic diet (KD) is a high-fat and low-carbohydrate diet with controlled amounts of protein. The use of drastic caloric restriction or ultralow-carbohydrate diets increases the production of ketone bodies, which are an alternative energy substrate in situations of insufficient glucose supply. Alzheimer’s disease (AD) and Parkinson’s disease are the most common neurodegenerative diseases in the
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The Effect of the Ketogenic Diet on the Therapy of Neurodegenerative Diseases and Its Impact on Improving Cognitive Functions Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-30
The ketogenic diet (KD) is a high-fat and low-carbohydrate diet with controlled amounts of protein. The use of drastic caloric restriction or ultralow-carbohydrate diets increases the production of ketone bodies, which are an alternative energy substrate in situations of insufficient glucose supply. Alzheimer’s disease (AD) and Parkinson’s disease are the most common neurodegenerative diseases in the
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Awareness of Instrumental Activities of Daily Living Disability: Pilot Study for Elderly Requiring Care and Caregivers Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-09 Yukiko Suzuki, Takayuki Sudo, Hideki Mochizuki
Aim: We aimed to investigate differences in the awareness of instrumental activities of daily living (IADL) disability between elderly patients with and without dementia requiring care. Methods: We assessed 25 elderly individuals requiring care and their primary caregivers using the Lawton IADL scale, with score differences between the patients and their caregivers representing the level of impaired
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Awareness of Instrumental Activities of Daily Living Disability: Pilot Study for Elderly Requiring Care and Caregivers Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-09
Aim: We aimed to investigate differences in the awareness of instrumental activities of daily living (IADL) disability between elderly patients with and without dementia requiring care. Methods: We assessed 25 elderly individuals requiring care and their primary caregivers using the Lawton IADL scale, with score differences between the patients and their caregivers representing the level of impaired
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Effect of Time to Detection on the Measured Concentrations of Blood Proteins Associated with Alzheimer’s Disease Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-03 Hsin-Hsien Chen, Chia-Shin Ho, Ming-Hung Hsu, Yu-Chen Lin, Jui-Feng Chang, Shieh-Yueh Yang
Background: For assays using immunomagnetic reduction, a reagent composed of antibody-functionalized magnetic nanoparticles is dispersed in phosphate-buffered saline solution. The real-time signals of alternating-current (ac) magnetic susceptibility, χac, of the reagent are subsequently recorded after mixing the reagent with a biofluid sample. After mixing the reagent and sample, the reduction in χac
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Cognitive Reserve Mediates the Relation between Neighborhood Socio-Economic Position and Cognitive Decline Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-03 Andreas Ihle, Rainer Gabriel, Michel Oris, Élvio R. Gouveia, Bruna R. Gouveia, Adilson Marques, Priscila Marconcin, Matthias Kliegel
Introduction: We investigated the mediating role of leisure activity engagement as marker of cognitive reserve in the relation between neighborhood socio-economic position (SEP) and cognitive decline over 6 years. Methods: The study analyzed longitudinal data from 897 older adults who participated in the two waves (2011 and 2017) of the Vivre-Leben-Vivere (VLV) survey in Switzerland (M = 74.33 years
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Effect of Time to Detection on the Measured Concentrations of Blood Proteins Associated with Alzheimer’s Disease Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-03
Background: For assays using immunomagnetic reduction, a reagent composed of antibody-functionalized magnetic nanoparticles is dispersed in phosphate-buffered saline solution. The real-time signals of alternating-current (ac) magnetic susceptibility, χac, of the reagent are subsequently recorded after mixing the reagent with a biofluid sample. After mixing the reagent and sample, the reduction in χac
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Cognitive Reserve Mediates the Relation between Neighborhood Socio-Economic Position and Cognitive Decline Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-03
Introduction: We investigated the mediating role of leisure activity engagement as marker of cognitive reserve in the relation between neighborhood socio-economic position (SEP) and cognitive decline over 6 years. Methods: The study analyzed longitudinal data from 897 older adults who participated in the two waves (2011 and 2017) of the Vivre-Leben-Vivere (VLV) survey in Switzerland (M = 74.33 years
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Effect of Diabetes Mellitus on Daily Functioning and Cognition of Alzheimer’s Disease Patients Evaluated by DASC-21 Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-02 Hiroshi Yoshino, Hajime Takechi
Introduction: Diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). It has also been pointed out that AD associated with DM may have unique characteristics. However, the characteristics of impairment in daily functioning when associated with DM have not been sufficiently investigated. Methods: In the present study, we compared the characteristics of 261 patients with AD diagnosed in
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Effect of Diabetes Mellitus on Daily Functioning and Cognition of Alzheimer’s Disease Patients Evaluated by DASC-21 Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-05-02
Introduction: Diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). It has also been pointed out that AD associated with DM may have unique characteristics. However, the characteristics of impairment in daily functioning when associated with DM have not been sufficiently investigated. Methods: In the present study, we compared the characteristics of 261 patients with AD diagnosed in
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Early-Stage MRI Volumetric Differences in White Matter Hyperintensity and Temporal Lobe Volumes between Autopsy-Confirmed Alzheimer’s Disease, Cerebral Small Vessel Disease, and Mixed Pathologies Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-04-26 Dixon Yang, Arjun Masurkar
Introduction: Alzheimer’s disease (AD) and cerebral small vessel disease (CVSD) both contribute to age-related cognitive decline but can be difficult to clinically distinguish at early stages. At mild cognitive impairment (MCI), we investigated brain MRI volumetric differences in white matter hyperintensities (WMH), frontal and temporal lobe volumes between neuropathologically defined groups of cerebral
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Early-Stage MRI Volumetric Differences in White Matter Hyperintensity and Temporal Lobe Volumes between Autopsy-Confirmed Alzheimer’s Disease, Cerebral Small Vessel Disease, and Mixed Pathologies Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-04-26
Introduction: Alzheimer’s disease (AD) and cerebral small vessel disease (CVSD) both contribute to age-related cognitive decline but can be difficult to clinically distinguish at early stages. At mild cognitive impairment (MCI), we investigated brain MRI volumetric differences in white matter hyperintensities (WMH), frontal and temporal lobe volumes between neuropathologically defined groups of cerebral
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Pronoun Use among Caregivers of People Living with Dementia: Associations with Dementia Severity Using Text Analysis of a Natural Language Sample Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-04-21 Alissa Bernstein Sideman, Jenna L. Wells, Jennifer Merrilees, Suzanne M. Shdo, Claire I. Yee, Katherine L. Possin, Robert W. Levenson
Introduction: Family caregivers of persons living with dementia (PLWDs) have extensive social, physical, emotional, and financial responsibilities. However, less is known about the relationship and interpersonal connection between caregivers and PLWDs. We examined caregiver pronoun use, as an index of the connection between the caregiver and PLWD and its associations with the caregiver’s and PLWD’s
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Pronoun Use among Caregivers of People Living with Dementia: Associations with Dementia Severity Using Text Analysis of a Natural Language Sample Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-04-21
Introduction: Family caregivers of persons living with dementia (PLWDs) have extensive social, physical, emotional, and financial responsibilities. However, less is known about the relationship and interpersonal connection between caregivers and PLWDs. We examined caregiver pronoun use, as an index of the connection between the caregiver and PLWD and its associations with the caregiver’s and PLWD’s
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Discrepancy in Fluid and Crystallized Intelligence: An Early Cognitive Marker of Dementia from the LASI-DAD Cohort Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-04-04 Swati Bajpai, Ashish Dutt Upadhayay, Joyita Banerjee, Avinash Chakrawarthy, Prashun Chatterjee, Jinkook Lee, Aparajit Ballav Dey
Background: Cognitive aging is a complex phenomenon, which comprises various cognitive skills, broadly categorized into fluid and crystallized intelligence. Crystallized intelligence (gc) tends to be maintained, as opposed to fluid intelligence (gf), which tends to decline rapidly with age. The association of the two with cognitive decline remains a matter of conjecture requiring further research.
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Vietnamese Version of Cornell Scale for Depression in Dementia at an Outpatient Memory Clinic: A Reliability and Validity Study Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-03-24 Tan Thanh Huynh, Nguyen Tran Thanh Nguyen, Tien Dong Phuong Nguyen, Thang Cong Tran
Background: In Vietnam, there has been, currently, no standardized tool for depression assessment for people with dementia (PWD). Cornell Scale for Depression in Dementia (CSDD) is a widely studied and used scale for PWD worldwide. Objectives: The aim of this study was to standardize the Vietnamese version of the CSDD (V-CSDD) in depression assessment in PWD through reliability and validity examination
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Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-03-24 Nafise Noroozi, Maryam Shayan, Adeleh Maleki, Faezeh Eslami, Nastaran Rahimi, Robab Zakeri, Zohreh Abdolmaleki, Ahmad Reza Dehpour
Introduction: The leading cause of memory impairment is dementia-related disorders. Since current treatments for memory impairment target the neuroinflammatory pathways, we selected dapsone, an anti-inflammatory agent, to evaluate its effects on scopolamine-induced memory impairment in mice and the underlying role of nitric oxide (NO). Methods: Scopolamine (1 mg/kg, intraperitoneal [i.p.]) was used
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Erratum Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-03-10
Dement Geriatr Cogn Disord Extra 2022;12:33
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Correlations between Hand Dexterity and Bimanual Coordination on the Activities of Daily Living in Older Adults with Mild Cognitive Impairment Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-02-18 Prathomchai Rattanawan
Background/Aims: Many motor impairments are present in older adults with cognitive decline. One of them is the impairment of hand dexterity and bimanual coordination that result in poor functional ability in the activities of daily living (ADL). This study investigated the effects of hand dexterity and bimanual coordination declination on the sub-domains of ADL in older adults with mild cognitive impairment
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Does Elevated Alcohol Consumption Delay the Diagnostic Assessment of Cognitive Impairment among Older Adults? Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-02-07 Ben Kamsvaag, Kjerstin Tevik, Jūratė Šaltytė Benth, Bei Wu, Sverre Bergh, Geir Selbaek, Anne-Sofie Helvik
Introduction: The time from symptom debut to assessment of cognitive impairment (TSA) is usually substantial, and many factors can influence the length of this interval. Our objective was to discern whether elevated alcohol consumption is associated with TSA. Methods: Alcohol consumption was measured among 3,236 older Norwegians assessed for cognitive impairment. Elevated consumption was defined as
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The Assessments of Music Therapy for Dementia Based on the Cochrane Review Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-01-21 Makiko Abe, Ken-ichi Tabei, Masayuki Satoh
Background: Research on music therapy for dementia has taken a variety of measures and has been slow to consolidate evidence. Examining the outcomes that are currently being investigated and the measures that have been used can be useful for future research on music therapy for dementia. Objectives: This study used cited original papers from a review in the Cochrane Database of Systematic Reviews to
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Demographic Data Differences in Perceived Control over Nursing Practice among Nurses Caring for Nursing Home Residents Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2022-01-17 Mohammad Rababa, Shatha Al-Sabbah, Dania Bani Hamad
Introduction: Control over nursing practice is crucial for improved quality of life for nursing home (NH) residents. Nevertheless, little is known about the association of nurses’ demographic data with their perceived control over nursing practice in Jordan and beyond. Therefore, this study aimed at examining the differences in nurses’ levels of perceived control over nursing practice based on their
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A Review of Functional Neuroimaging in People with Down Syndrome with and without Dementia Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-27 Funmi Deinde, Jay Kotecha, Lilian Suh Lih Lau, Sagnik Bhattacharyya, Latha Velayudhan
Background: Individuals with Down syndrome (DS) are at high risk of dementia which is difficult to diagnose in DS. Neuroimaging has been identified as a potential tool to aid diagnosis by detecting changes in brain function. We carried out a review comparing functional neuroimaging in DS individuals with and without dementia. Summary: A literature search was conducted using PubMed to identify relevant
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Googling Alzheimer Disease: An Infodemiological and Ecological Study Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-27 Bernadeth Lyn C. Piamonte, Veeda Michelle M. Anlacan, Roland Dominic G. Jamora, Adrian I. Espiritu
Introduction: Understanding the emergent role of the internet on the health-seeking behavior of people is critical not only in the areas of medicine and public health but also in the field of infodemiology. Methods: Using Google Trends, data on global search queries for Alzheimer disease (AD) between January 2004 and April 2021 were analyzed. The relationship between online interest, as reflected by
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Translation, Cross-Cultural Adaptation, and Validation of the Portuguese Version of the Rotterdam Elderly Pain Observation Scale Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-20 Julieta Seixas-Moizes, Anneke Boerlage, Érica Negrini Lia, Lucas Emmanuel Lopes e Santos, Miriane Lucindo Zucoloto, Fabíola Dach, Priscila Colavite Papassidero, Laís Almeida Leal Wichert-Ana, Oscar Della Pasqua, Marianne Louise Wiesebron, Tatiana Reis Icuma, Vera Lucia Lanchote, Eduardo Barbosa Coelho, Dick Tibboel, Lauro Wichert-Ana
Introduction: This study reports on the translation, cultural adaptation, and validation of a Portuguese version of the Rotterdam Elderly Pain Observation Scale (REPOS), a Dutch scale to assess pain in patients who cannot communicate, with or without dementia. Methods: This is a multicenter study in pain and neurological units involving Brazil (clinical phase) and the Netherlands (training phase).
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Prediction of Postoperative Delirium after Gastrointestinal Surgery Using the Mie Constructional Apraxia Scale Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-09 Yosuke Tenpaku, Masayuki Satoh, Kenji Kato, Kazuhisa Fujinaga, Yuji Haruki, Hiroki Nakahashi, Keisuke Morikawa, Yasunori Imaoka, Hiroyuki Takemura, Hiroshi Tatsumi
Background: Postoperative delirium (POD) is a transient postoperative complication that occurs after surgical procedures. Risk factors reported for POD include dementia and cognitive decline. The purpose of this study was to identify predictors of POD by examining the use of preoperative neuropsychological tests, including the Mie Constructional Apraxia Scale (MCAS), and patient background factors
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One-Year Change in Locus of Control among People with Dementia Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-07 Ingeborg Halse, Guro Hanevold Bjørkløf, Knut Engedal, Geir Selbæk, Maria Lage Barca
Introduction: Knowledge of how perceptions of personal control change over time may provide valuable insights into how people cope with having dementia. The present study aimed to examine change in locus of control over a 12-month period in persons with dementia. Method: The study included 52 participants with dementia. Locus of control was measured with the Locus of Control of Behavior Scale (LoCB)
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Impact of Plasma Donepezil Concentration on Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-02 Yoshiyuki Kagawa, Yoshiaki Yamamoto, Ayami Ueno, Kengo Inomata, Mayu Tezuka, Takashi Osawa, Yasuharu Yazawa, Toshio Maeda, Tomokazu Obi
Background/Aims: The behavioral and psychological symptoms of dementia (BPSD) detract from the quality of life of not only dementia patients but also their family members and caregivers. Donepezil is used to treat Alzheimer’s disease and is metabolized via cytochrome P450 (CYP) 2D6 and CYP3A4/5. It is controversial whether donepezil improves or exacerbates BPSD. This study investigated the relationships
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Effectiveness and Safety of Aromatherapy in Managing Behavioral and Psychological Symptoms of Dementia: A Mixed-Methods Systematic Review Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-12-02 Becky Siu Yin Li, Carmen Wing Han Chan, Minjie Li, Irene Kit Yee Wong, Yvonne Hoi Un Yu
Introduction: Behavioral and psychological symptoms of dementia (BPSD) is the most prominent and distressing manifestation for older persons with dementia (PWD) and caregivers. Aromatherapy has demonstrated its effectiveness in managing BPSD in various studies. However, previous studies and systematic reviews have obtained inconsistent findings, and a review of qualitative studies is yet to be conducted
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A Survey of Dementia Knowledge and Recognition of Dementia Prevention and Practice in Healthy Older Adults Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-11-18 Nanako Yamane, Kanto Tsukagoshi, Miharu Hisada, Mina Yamaguchi, Yukiko Suzuki
Aim: The aim of this study was to investigate the level of dementia knowledge and behaviors recognized as dementia-preventive and the practice thereof among healthy older adults who are highly motivated to engage in activities. Methods: The participants were older adults registered at the Silver Human Resource Center of city A, and participants anonymously filled questionnaires through the aggregation
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What Are the Key Points of Treatment for Cases of Mild Cognitive Impairment? Based on the Evaluation of Cognitive Function Tasks in the ADASJcog Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-11-16 Yoshihiko Yoshii, Akiko Takahashi, Miyuki Ishizawa
Background/Aims: The aims of this study were to identify the degree of atrophy of the hippocampus in image findings and which cognitive function items should be focused on when treating mild cognitive impairment. Methods: A total of 66 cases with mild cognitive impairment were included in the study over a 1.5-year observation period. MR images were used to assess hippocampal atrophy, and cognitive
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Short- and Long-Term Functional Connectivity Differences Associated with Alzheimer’s Disease Progression Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-09-23 Jaime D. Mondragón, Ramesh Marapin, Peter Paul De Deyn, Natasha Maurits, for the Alzheimer’s Disease Neuroimaging Initiative
Introduction: Progression of amnestic mild cognitive impairment (aMCI) to Alzheimer’s disease (AD) is a clinical event with highly variable progression rates varying from 10–15% up to 30–34%. Functional connectivity (FC), the temporal similarity between spatially remote neurophysiological events, has previously been reported to differ between aMCI patients who progress to AD (pMCI) and those who do
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Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-09-17 Hediyeh Baradaran, Alen Delic, J. Scott McNally, Matthew Alexander, Jennifer J. Majersik, Dennis L. Parker, Adam de Havenon
Introduction: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study. Methods: We included participants with common carotid compliance measurements at visit 1 (1987–1989) and volumetric brain MRI at visit 5 (2011–2013). The primary outcomes
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Prevalence of Dementia and Associated Factors among Older Adults in Latin America during the COVID-19 Pandemic Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-09-16 Marcio Soto-Añari, Loida Camargo, Miguel Ramos-Henderson, Claudia Rivera-Fernández, Lucia Denegri-Solís, Ursula Calle, Nicanor Mori, Ninoska Ocampo-Barbá, Fernanda López, Maria Porto, Nicole Caldichoury-Obando, Carol Saldías, Pascual Gargiulo, Cesar Castellanos, Salomon Shelach-Bellido, Norman López
Background: The COVID-19 pandemic has had a great impact on cognitive health in Latin American older adults, increasing the risk of cognitive impairment and dementia. Our objective was to analyze the prevalence of dementia and the associated factors in Latin American older adults during SARS-CoV-2 pandemic. Methods: A multicentric first phase cross-sectional observational study was conducted during
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Development and Evaluation of the Behavioral and Psychological Symptoms of Dementia Questionnaire 13-Item Version (BPSD13Q) Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-09-16 Taiga Fuju, Tetsuya Yamagami, Mio Ito, Noriko Naito, Haruyasu Yamaguchi
Introduction: Most behavioral and psychological symptoms of dementia (BPSD) scales have copyright issues and are difficult for care staff to use in daily care settings because they were primarily designed for physicians. Therefore, an easier tool for care staff is required. This study aimed to develop and validate the BPSD questionnaire 13-item version (BPSD13Q). Methods: We obtained data from 444
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Effects of Pet Therapy in Elderly Patients with Neurocognitive Disorders: A Brief Review Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-09-13 Chiara Sbrizzi, Walter Sapuppo
Introduction: Neurocognitive disorders (NCDs) are disturbances highly related to age. This means that, with the increasing trend in life expectancy, there is also an increase in this diagnosis, although NCDs are not exclusively found in the population over 65 years old. Likely, they will increase in the coming years together with improvements in diagnosis. In addition to the use of medicines and rehabilitative
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Are Analogue or Digital Clocks Friendlier for People Living with Dementia? Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-09-13 Akihiro Koreki, Keisuke Kusudo, Hisaomi Suzuki, Shoko Nozaki, Mitsumoto Onaya, Alison Bowes, Mitsuhiro Sado
Background: In ageing population, it is desirable to reduce the impact of cognitive decline on daily life. While various types of dementia-friendly environments have been proposed, the question still remains regarding whether analogue or digital clocks are friendlier for people with dementia. Methods: In clinical practice, we normally use our original clock reading test (10 analogue and 10 digital
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Determinants of Caregiver Burden in Early-Onset Dementia Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-08-13 Annalisa Chiari, Barbara Pistoresi, Chiara Galli, Manuela Tondelli, Giulia Vinceti, Maria Angela Molinari, Tindara Addabbo, Giovanna Zamboni
Introduction: Caregivers of patients with early-onset dementia (EOD) experience high levels of burden, which is known to be affected by caregivers’ psychological features as well as by patients’ and caregivers’ demographical and social variables. Although potential clinical, demographical, and social determinants have been separately examined, it is not known how they reciprocally interact. Methods:
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Performance of the Rowland Universal Dementia Assessment Scale in Screening Mild Cognitive Impairment at an Outpatient Setting Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-07-30 Manchumad Manjavong, Panita Limpawattana, Kittisak Sawanyawisuth
Introduction: Mild cognitive impairment (MCI) is defined as the symptomatic pre-dementia phase on the continuum of cognitive decline. Early recognition and application of potential interventions could prevent or delay the progression to dementia. The Rowland Universal Dementia Assessment Scale (RUDAS) shows good performance in the screening of dementia but has limited data regarding its diagnostic
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False Memory and Alzheimer’s Disease Pathology in Patients with Amnestic Mild Cognitive Impairment: A Study with Amyloid PET Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-06-11 Eun-Ji Choi, Bum Joon Kim, Hyung-Ji Kim, Miseon Kwon, Noh Eul Han, Sun-Mi Lee, Sungyang Jo, Sunju Lee, Jae-Hong Lee
Introduction: False memory, observed as intrusion errors or false positives (FPs), is prevalent in patients with Alzheimer’s disease, but has yet to be thoroughly investigated in patients with amnestic mild cognitive impairment (a-MCI) with Alzheimer’s disease pathology (ADP). We analyzed false versus veridical memory in individuals with a-MCI and measured the utility of false memory for ADP discrimination
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The Neuroinflammasome in Alzheimer’s Disease and Cerebral Stroke Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-06-10 Jong-hoon Lee, Chul Joong Lee, Jungwuk Park, So Jeong Lee, Su-hee Choi
Aim/Background: This review investigated a patient with Alzheimer’s disease (AD) treated with 4,4’-diaminodiphenyl sulfone (DDS) as a neuroinflammasome competitor. Methods: We monitored AD’s progression through numeric clinical staging (NCS) with a new biomarker. NCS was determined by the presence of AD symptoms and neuropsychiatric (NP) symptoms caused by anti-AD (AAD) drugs (D) as a biomarker. We
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Commentary for the Elderly in the Pandemic Era Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-06-10 Asif Khattak, Badar Kanwar, Consolato Sergi, Chul Joong Lee, Jenny Balentine, Jong-Hoon Lee, Jungwuk Park, So Jeong Lee, Su-Hee Choi
Dement Geriatr Cogn Disord Extra 2021;11:168–171
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Parental Age and the Risk for Alzheimer’s Disease in Offspring: Systematic Review and Meta-Analysis Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-06-08 Natalia Szejko, Pedro Macul Ferreira de Barros, Victor J. Avila-Quintero, Adam Lombroso, Michael Howard Bloch
Background: Alzheimer’s disease (AD) is the most common cause of dementia worldwide, accounting for 50–75% of all cases. While older maternal and paternal age at childbirth are established risk factors for Down syndrome which is associated with later AD, it is still not entirely clear whether parental age is a risk factor for AD. Previous studies have suggested contradictory findings. Objectives: We
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Effects of the Sonas Program on Anxiety and Depression in Nursing Home Residents with Dementia: A 6-Month Randomized Controlled Trial Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-06-08 Alka R. Goyal, Knut Engedal, Jūratė Šaltytė Benth, Benedicte Sørensen Strøm
Introduction: There is a dearth of evidence about the effects of Sonas, a multisensory stimulation on people with dementia (PWD). The main aim of this study was to examine the effects of the Sonas program on anxiety and depression in nursing home (NH) residents with dementia. Methods: In all, 120 PWD ≥65 years of age from 6 NHs were included in a randomized control trial and were allocated to 1 of
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Early Detection and Intervention for Patients with Delirium Admitted to the Department of Internal Medicine: Lessons from a Pilot Initiative Dement. Geriatr. Cogn. Disord. Extra Pub Date : 2021-06-02 Ron Oliven, Meital Rotfeld, Sharon Gino-Moor, Elad Schiff, Majed Odeh, Efrat Gil
Introduction: Older patients who arrive to the emergency room with delirium have a worse prognosis than others. Early detection and treatment of this problem has been shown to improve outcome. We have launched a project at our hospital to improve the care of patients who arrive delirious to the medical emergency room. The present article describes lessons that can be learned from this pilot initiative