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Harnessing Placebo Effects for the Treatment of Functional Cognitive Disorder: A Feasibility Pilot Study J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-02-12 Matthew J. Burke, Davide Cappon, David L. Perez, Alvaro Pascual-Leone, Emiliano Santarnecchi
Objective: Limited research has directly investigated whether and how placebo effects can be harnessed for the treatment of functional neurological disorder (FND), despite a long-standing and controversial history of interest in this area. Methods: A small exploratory study was conducted with adults with a cognitive subtype of FND recruited from a single cognitive neurology center in the United States
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Iron Supplementation in Management of Neurodevelopmental Disorders: Systematic Review, Meta-Analysis, and Qualitative Synthesis J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-02-12 Stephen D. Elliott, Mark L. Vickers, Gemma McKeon, Lars Eriksson, Eva Malacova, James G. Scott
Objective: The authors sought to explore the role of iron supplementation in the management of neurodevelopmental disorders among children and youths. Methods: A systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was undertaken. A subset of results was suitable for meta-analysis. The quality of the evidence and strength of the clinical
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From Software to Hardware: A Case Series of Functional Neurological Symptoms and Cerebrovascular Disease J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-02-12 Jan Coebergh, Shabana Habib, Tiago Teodoro, Mark Edwards, Matt Butler
Objective: Neuroimaging studies have identified alterations in both brain structure and functional connectivity in patients with functional neurological disorder (FND). For many patients, FND emerges from physical precipitating events. Nevertheless, there are a limited number of case series in the literature that describe the clinical presentation and neuroimaging correlates of FND following cerebrovascular
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Association of Win-Loss Record With Neuropsychiatric Symptoms and Brain Health Among Professional Fighters J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-01-23 Barry R. Bryant, Aaron I. Esagoff, Lisa Young, Natalia Kosyakova, Michael J.C. Bray, Lisa N. Richey, Varun Vohra, Guogen Shan, Andrea L.C. Schneider, Matthew E. Peters, Charles B. Bernick, Bharat R. Narapareddy
Objective: Repetitive head impacts in professional fighting commonly lead to head injuries. Increased exposure to repetitive head trauma, measured by the number of professional fights and years of fighting, has been associated with slower processing speed and smaller brain volumes. The impact of win-loss outcomes has been investigated in other sports, with several studies suggesting that individuals
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Longitudinal Influence of Prescribed Antidepressants on Fecal and Oral Microbiomes Among Veterans With Major Depressive Disorder J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-01-23 Andrew J. Hoisington, Kelly A. Stearns-Yoder, Christopher E. Stamper, Joseph A. Simonetti, David W. Oslin, Lisa A. Brenner
Objective: The purpose of this study was to evaluate the influence of a new course of antidepressant monotherapy on gut and oral microbiomes and the relationship to depressive symptoms. Methods: Longitudinal microbiome samples obtained from 10 U.S. veterans were analyzed. Baseline samples were taken before a new course of antidepressant monotherapy (either switching from a previous treatment or starting
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Symptom Attribution and Neuropsychological Outcomes Among Treatment-Seeking Veterans With a History of Traumatic Brain Injury J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-01-09 Victoria C. Merritt, Grace J. Goodwin, McKenna S. Sakamoto, Laura D. Crocker, Amy J. Jak
Objective: In this cross-sectional study, the authors aimed to examine relationships between illness perception, measured as symptom attribution, and neurobehavioral and neurocognitive outcomes among veterans with a history of traumatic brain injury (TBI). Methods: This study included 55 treatment-seeking veterans (N=43 with adequate performance validity testing) with a remote history of TBI (80% with
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Impulsivity and Psychiatric Diagnoses as Mediators of Suicidal Ideation and Suicide Attempts Among Veterans With Traumatic Brain Injury J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2024-01-09 Alexandra L. Aaronson, Bridget Smith, Kelly Krese, Meghan Barnhart, Maheen Adamson, Harriet de Wit, Noah S. Philip, Lisa A. Brenner, Theresa Bender-Pape, Amy A. Herrold
Objective: Traumatic brain injury (TBI) is a risk factor for suicide, but questions related to mechanisms remain unanswered. Impulsivity is a risk factor for suicide and is a common sequela of TBI. The authors explored the relationships between TBI and both suicidal ideation and suicide attempts and explored whether impulsivity and comorbid psychiatric diagnoses mediate these relationships. Methods:
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Resting-State Functional Connectivity of the Anterior Cingulate Cortex Among Persons With Mood Disorders and Suicidal Behaviors J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-11-20 Elisa Ambrosi, Kaylah N. Curtis, Puneetha Goli, Michelle A. Patriquin, David B. Arciniegas, Alessio Simonetti, Gianfranco Spalletta, Ramiro Salas
Objective: To assess whether anterior cingulate cortex (ACC) abnormalities contribute to suicide risk in major depressive disorder and bipolar disorder, the investigators compared resting-state functional connectivity (rsFC) of ACC subdivisions between individuals with major depressive or bipolar disorder with and without a lifetime history of suicidal behavior. Methods: Forty-two inpatients with and
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Psychiatric Screening Measures in Behavioral Variant Frontotemporal Dementia. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-11-20 Peter S Pressman,Joie Molden,Hal S Wortzel,Evan Plys,Jonathan H Woodcock,Christopher M Filley,David B Arciniegas
OBJECTIVE Behavioral variant frontotemporal dementia (bvFTD) is sometimes misdiagnosed as a primary psychiatric disorder, such as major depressive disorder, bipolar disorder, an anxiety disorder, autism spectrum disorder (ASD), or attention-deficit hyperactivity disorder (ADHD). Nonspecialists often use screening measures for primary psychiatric disorders in early assessments of persons with bvFTD
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Association Between Psychosocial Stress and Brain Aging: Results of the Population-Based Cohort Study of Health in Pomerania (SHIP). J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-10-18 Francisca S Rodriguez,Hans J Grabe,Stefan Frenzel,Johanna Klinger-König,Robin Bülow,Henry Völzke,Wolfgang Hoffmann
OBJECTIVE Recent studies suggest that psychosocial factors can have an impact on brain health. Yet, it is unclear whether psychosocial stress affects aging of the brain. The aim of the study was to investigate the association between psychosocial stress and brain aging. METHODS Data from the German population-based cohort Study of Health in Pomerania (N=991; age range 20-78 years) were used to calculate
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Creating a "Brain-Mind-Body Interface Disorders" Diagnostic Category Across Specialties. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-10-18 Julie Maggio,Caitlin Adams,David L Perez
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Online Core Curriculum and Mastery (OCCAM): A Behavioral Neurology & Neuropsychiatry (BNNP) Curricular Needs Assessment J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-09-20 Lealani Mae Y. Acosta, Maya Neeley, Charlene M. Dewey
Behavioral neurology & neuropsychiatry (BNNP) fellowships are accredited by the United Council for Neurologic Subspecialties (UCNS). Programs cover the UCNS-recommended topics differently. A curriculum accessible to all fellowships would standardize education and identify gaps in topics that are less well covered across programs. The purpose of the present needs assessment was to inform the development
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Dual Residency Training in Neurology and Psychiatry: History and Current Practice. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-09-20 Sheldon Benjamin
In the early 20th century, neurology training included more experience in psychiatry, and psychiatry training included more training in neurology than what is currently required. After World War I, the increased need for differential diagnosis of what might now be called functional neurological disorders resulted in the military encouraging combined residency training in neurology and psychiatry and
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Focal Lesion in the Intraparietal Sulcus: A Case for Network-Dependent Release Hallucinations. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-09-20 Yidi Wang,Andrew R Pines,Joseph Y Yoon,Summer B Frandsen,Edison K Miyawaki,Shan H Siddiqi
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Practical Application of a Battery of Brief Tools to Evaluate Geriatric Medical Inpatients for the Three Ds J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-09-05 Marcela Alviz Núñez, María Margarita Villa García, Maria Carolina Gonzalez, María Botero Urrea, Juan D. Velásquez-Tirado, María V. Ocampo, Paula T. Trzepacz, José G. Franco
Objective: The investigators aimed to identify the clinical characteristics of patients with or without delirium and preexisting depression, dementia, both, or neither by using validated tools easily administered in clinical practice. Methods: In this cross-sectional prospective observational study conducted in Medellín, Colombia, 200 geriatric inpatients were evaluated with the Delirium Diagnostic
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Factors Associated With Anxiety After Hemorrhagic Stroke J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-09-05 Anlys Olivera, Sarah Ecker, Aaron Lord, Lindsey Gurin, Koto Ishida, Kara Melmed, Jose Torres, Cen Zhang, Jennifer Frontera, Ariane Lewis
Objective: A significant number of patients develop anxiety after stroke. The objective of this study was to identify risk factors for anxiety after hemorrhagic stroke that may facilitate diagnosis and treatment. Methods: Patients admitted between January 2015 and February 2021 with nontraumatic hemorrhagic stroke (intracerebral [ICH] or subarachnoid [SAH] hemorrhage) were assessed telephonically 3
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Poststroke Depression: An Update J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-08-10 Robert G. Robinson, Ricardo E. Jorge, Sergio E. Starkstein
The presence of neuropsychiatric disorders after stroke has been recognized for more than 100 years, but controlled systematic studies did not begin until the 1970s. The most clinically important advances, however, have been in the treatment and prevention of poststroke depression (PSD). Recent meta-analyses of randomized controlled trials (RCTs) for the treatment of PSD have demonstrated the efficacy
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Novel Oppositional Defiant Disorder or Conduct Disorder 24 Months After Traumatic Brain Injury in Children and Adolescents J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-08-10 Daniel S. Lowet, Florin Vaida, John R. Hesselink, Linda Ewing-Cobbs, Russell J. Schachar, Sandra B. Chapman, Erin D. Bigler, Elisabeth A. Wilde, Ann E. Saunders, Tony T. Yang, Olga Tymofiyeva, Mingxiong Huang, Jeffrey E. Max
Objective: The authors sought to identify predictive factors of new-onset or novel oppositional defiant disorder or conduct disorder assessed 24 months after traumatic brain injury (TBI). Methods: Children ages 5 to 14 years who had experienced TBI were recruited from consecutive hospital admissions. Soon after injury, participants were assessed for preinjury characteristics, including psychiatric
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Adjunctive Memantine for Catatonia Due to Anti-NMDA Receptor Encephalitis. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-07-07 Katherine Kim,Rachel Caravella,Allison Deutch,Lindsey Gurin
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Measuring Antisocial Behaviors in Behavioral Variant Frontotemporal Dementia With a Novel Informant-Based Questionnaire. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-07-07 Tony X Phan,Jerica E Reeder,Lindsey C Keener,Ciaran M Considine,David H Zald,Daniel O Claassen,R Ryan Darby
OBJECTIVE Antisocial behaviors are common and problematic among patients with behavioral variant frontotemporal dementia (bvFTD). In the present study, the investigators aimed to validate an informant-based questionnaire developed to measure the extent and severity of antisocial behaviors among patients with dementia. METHODS The Social Behavior Questionnaire (SBQ) was developed to measure 26 antisocial
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Outcome in Pediatric Functional Tic Disorders Diagnosed During the COVID-19 Pandemic. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-06-01 Alexander Mathew,Amal Abu Libdeh,James Patrie,Jordan Garris
OBJECTIVES The incidence of pediatric functional tics has surged during the COVID-19 pandemic with little known about prognosis. To address this knowledge gap, the investigators examined clinical courses of functional tics diagnosed during the pandemic and explored factors predicting prognosis. METHODS Study personnel reviewed electronic medical records of 29 pediatric patients diagnosed as having
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Alterations in Resting-State Interhemispheric Coordination With Refractory Auditory Verbal Hallucinations in Schizophrenia. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-06-01 Huichang Qian,Xiaozheng Liu,Zhongwei Guo,Guanjun Wang,Xiuhong Chen,Jian Liu
OBJECTIVE The purpose of this study was to investigate resting-state interhemispheric functional connectivity in patients with schizophrenia and refractory auditory verbal hallucinations (RAVHs) by using voxel-mirrored homotopic connectivity (VMHC). METHODS Thirty-four patients with schizophrenia and RAVHs (RAVH group), 23 patients with schizophrenia but no auditory verbal hallucinations (non-AVH group)
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Preexisting Depression and Ambulatory Status After Stroke: Florida-Puerto Rico Collaboration to Reduce Stroke Disparities. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-05-08 Amy K Starosciak,Kefeng Wang,Hao Ying,Kaushik Ravipati,Samantha Spring,Carolina M Gutierrez,Hannah Gardener,David Z Rose,Dianne Foster,Chuanhui Dong,Angus Jameson,Ayham Alkhachroum,Jose G Romano,Ralph L Sacco,Tatjana Rundek,Negar Asdaghi
OBJECTIVE Stroke is a global public health burden, and therefore it is critical to identify modifiable risk factors to reduce stroke incidence and improve outcomes. Depression is such a risk factor; however, the association between preexisting depression and stroke outcomes, such as independent ambulation, is not well studied, especially among racial-ethnic minority groups. To address this gap in the
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Suicidal Thoughts and Behaviors in Anti-NMDA Receptor Encephalitis: Psychopathological Features and Clinical Outcomes. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-05-08 Alberto Tellez-Martinez,Miguel Restrepo-Martinez,Mariana Espinola-Nadurille,Victoria Martinez-Angeles,Francisco Martínez-Carrillo,Ava Easton,Thomas Pollak,Jesus Ramirez-Bermudez
OBJECTIVE A wide variety of neuropsychiatric symptoms are described during the acute phase of anti-N-methyl-d-aspartate receptor encephalitis (ANMDARE), including psychosis, mania, depression, and catatonia, but there are few reports on suicidal thought and behaviors in ANMDARE. To address this gap in the literature, the authors measured the presence of suicidal thoughts and behaviors among a large
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Changes in Posttraumatic Stress Disorder Symptoms With Integrative Psychotherapy for Functional Neurological Symptom Disorder. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-04-24 Alex Calderbank,Cordelia Gray,Aimee Morgan-Boon,Markus Reuber
OBJECTIVE Patients with functional neurological symptom disorder (FNSD) report high rates of traumatization and have high levels of posttraumatic stress disorder (PTSD) symptoms. Psychotherapy is a mainstay of treatment for persons with FNSD. In this study, the investigators explored changes in PTSD symptoms and health-related quality of life after psychotherapy among persons with FNSD and examined
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Dimensional Assessment of Depression and Anxiety in a Clinical Sample of Adults With Chronic Tic Disorder. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-04-24 David A Isaacs,Ashruta Narapareddy,Michelle R Eckland,Heather R Riordan
OBJECTIVE Among adults with Tourette syndrome, depression and anxiety symptoms are widely prevalent and consistently associated with poor quality of life. Important knowledge gaps remain regarding mood and anxiety dimensions of the adult Tourette syndrome phenotype. Taking a dimensional approach, this study sought to determine the prevalence, severity, and clinical correlates of depression and anxiety
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Mania Following Traumatic Brain Injury: A Systematic Review. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-04-06 Anna D Li,Samantha M Loi,Dennis Velakoulis,Mark Walterfang
OBJECTIVE Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. Mania is an uncommon, but debilitating, psychiatric occurrence following TBI. The literature on mania following TBI is largely limited to case reports and case series. In the present review, the investigators describe the clinical, diagnostic, and treatment characteristics of mania following TBI. METHODS
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Introversion and Neuroticism in Akinetic-Rigid Parkinson's Disease: Association With Frontal-Executive Dysfunction. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-03-31 Natascia De Lucia,Anna De Rosa,Sandra Perillo,Raffaele Sperandeo,Giuseppe De Michele,Nelson Mauro Maldonato
OBJECTIVE Personality changes have often been reported among people with Parkinson's disease (PD); however, no studies have investigated the associations between personality traits, cognitive function, and specific motor symptoms. In this study, the investigators assessed whether particular personality traits were associated with specific motor subtypes of PD (e.g., tremor-dominant and akinetic-rigid
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Long-Term Changes in Poststroke Depressive Symptoms: Effects of Functional Disability and Social Support. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-03-31 Jae-Chan Ryu,Jong S Kim,
OBJECTIVE Long-term changes in specific depressive symptoms have rarely been studied in stroke patients. Such changes and the effects of social support and functional disability on specific symptoms after a long-term follow-up period (LTP) were investigated. METHODS The Montgomery-Åsberg Depression Rating Scale (MADRS), ENRICHD Social Support Instrument, and modified Rankin Scale (mRS) for functional
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Neuropsychiatric Status of Patients With Multiple Sclerosis Across Disease Duration Intervals. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-02-14 David E Freedman,Jiwon Oh,Anthony Feinstein
OBJECTIVES The neuropsychiatric sequelae of multiple sclerosis (MS) are important predictors of morbidity and mortality. The authors examined how symptoms of depression, anxiety, fatigue, subjective cognitive impairment, and objective cognitive dysfunction varied with disease duration. They also explored changes in the use of disease-modifying therapies, psychotropic medications, and psychotherapies
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Elimination of Refractory Aggression and Self-Injury With Contingent Skin Shock. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-02-14 Nathan Blenkush,Miles Cunningham
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Treatment of Comorbid Anxiety and Epilepsy. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-02-14 Jay A Salpekar,Grace J Ma,Jonathan Mietchen,Jeremy Mani,Jana E Jones
Objective:Anxiety is among the most common psychiatric illnesses, and it commonly co-occurs with epilepsy. This review of the existing literature on anxiety comorbid with epilepsy aims to generate new insights into strategies for assessment and treatment.Methods:The authors conducted a narrative literature review to select key publications that help clarify the phenomenology and management of comorbid
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Posttraumatic Stress Symptoms Among COVID-19 Survivors After Hospitalization. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-30 Evie Sobczak,Emily P Swafford,Daniel Samano,Danielle Bass,Pardis Ghamasaee,Mohan Kottapally,Amedeo Merenda,Kristine O'Phelan,Jose G Romano,Ralph L Sacco,Tatjana Rundek,Ayham Alkhachroum
OBJECTIVE Limited data are available on posttraumatic stress symptoms (PTSS) among COVID-19 survivors. This study aimed to contribute to this knowledge base. METHODS PTSS among COVID-19 survivors who had been hospitalized were investigated. Patients were identified as COVID-19 positive at hospital admission. COVID-19 survivors were surveyed with the Posttraumatic Stress Disorder Checklist (PCL-5) between
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NMDA Receptor Antibodies and Neuropsychiatric Symptoms in Parkinson's Disease. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-30 Lucy L Gibson,Thomas A Pollak,Melanie Hart,Amanda Heslegrave,Abdul Hye,Andrew J Church,Neghat Lakdawala,Timothy R Nicholson,Lucia Batzu,Silvia Rota,Dhaval Trivedi,Henrik Zetterberg,Kallol Ray Chaudhuri,Dag Aarsland
OBJECTIVE N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoantibody-mediated neurological syndrome with prominent cognitive and neuropsychiatric symptoms. The clinical relevance of NMDAR antibodies outside the context of encephalitis was assessed in this study. METHODS Plasma from patients with Parkinson's disease (PD) (N=108) and healthy control subjects (N=89) was screened at baseline
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Case Study 6: The Diagnostic Challenge of a 75-Year-Old Man Who Had, Then Didn't Have, Then Did Have Alzheimer's Disease. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Sergio A Ramírez-Salazar,Cassie MacRae,Mel B Feany,Michael Miller,Hyun-Sik Yang,Mary-Ellen Meadows,Scott M McGinnis,David Silbersweig,Seth A Gale,Kirk R Daffner
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Introducing JNCN Editor's Choice: Curated Collections From The Journal of Neuropsychiatry and Clinical Neurosciences. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 David B Arciniegas
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Medical Metaverse, Part 2: Artificial Intelligence Algorithms and Large Language Models in Psychiatry and Clinical Neurosciences. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Wilfredo López-Ojeda,Robin A Hurley
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Advancing Neuropsychiatric Practice, Training, and Research for 30 Years: ANPA's Committee on Research. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Selma Aybek,Mandana Modirrousta,David B Arciniegas
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Digital Innovation in Neuroanatomy: Three-Dimensional (3D) Image Processing and Printing for Medical Curricula and Health Care. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Wilfredo López-Ojeda,Robin A Hurley
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Case Study 5: A 74-Year-Old Man With Dysphagia, Weakness, and Memory Loss. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Scott M McGinnis,Ruth F McCann,Viharkumar Patel,Christopher T Doughty,Michael B Miller,Seth A Gale,David A Silbersweig,Kirk R Daffner
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Ketone Bodies and Brain Metabolism: New Insights and Perspectives for Neurological Diseases. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Wilfredo López-Ojeda,Robin A Hurley
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Case Study 4: A 68-Year-Old Woman With Progressive Cognitive Decline and Anxiety. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Rishab Gupta,Vihar Patel,Scott M McGinnis,David Silbersweig,Michael B Miller,Mel B Feany,Kirk Daffner,Seth A Gale
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The Medical Metaverse, Part 1: Introduction, Definitions, and New Horizons for Neuropsychiatry. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2023-01-01 Wilfredo López-Ojeda,Robin A Hurley
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Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-12-05 Janina Krell-Roesch, Jeremy A. Syrjanen, Jelena Bezold, Sandra Trautwein, Bettina Barisch-Fritz, Walter K. Kremers, Julie A. Fields, Eugene L. Scharf, David S. Knopman, Gorazd B. Stokin, Ronald C. Petersen, Darko Jekauc, Alexander Woll, Maria Vassilaki, Yonas E. Geda
Objective: This study examined associations between physical activity (PA) and neuropsychiatric symptoms (NPS) in older adults free of dementia. Methods: This cross-sectional study included 3,222 individuals ≥70 years of age (1,655 men; mean±SD age=79.2±5.6; cognitively unimpaired, N=2,723; mild cognitive impairment, N=499) from the population-based Mayo Clinic Study of Aging. PA (taken as a presumed
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Cotard's Delusion From Subacute Encephalopathy With Seizures in Alcoholism. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-12-05 Mario F Mendez
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Attachment and Clinical Outcomes Among Treatment-Seeking Adults With Persistent Symptoms After Mild Traumatic Brain Injury J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-11-10 Shuyuan Shi, Mathilde Rioux, Amrit K. Dhariwal, Noah D. Silverberg
Objective: Interpersonal attachment influences the development and course of disease. Overreliance on insecure attachment strategies may increase risk for poor disease outcomes. This study aimed to investigate largely unexplored relationships between attachment strategies and clinical outcomes among adults with persistent symptoms after mild traumatic brain injury (mTBI). Methods: Participants with
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Frequency and Pathophysiology of Apathy in Huntington Disease: A Systematic Review and Meta-Analysis J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-11-10 Shayan Abdollah Zadegan, Hannah M. Coco, Kirthan S. Reddy, Kendra M. Anderson, Antonio L. Teixeira, Erin Furr Stimming
Objective: Apathy is a common behavioral symptom of Huntington disease (HD). This systematic review describes current evidence on the pathophysiology, assessment, and frequency of apathy in HD. Methods: This systematic review was conducted in accordance with PRISMA guidelines. Using a comprehensive search strategy, the investigators searched the MEDLINE, Embase, and PsycINFO databases. All studies
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Neuropsychiatric Features of Fregoli Syndrome: An Individual Patient Meta-Analysis J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-09-29 Maria Teixeira-Dias, Amber Kaur Dadwal, Vaughan Bell, Graham Blackman
Objective: Fregoli syndrome is a rare delusion characterized by the belief that familiar people are presenting themselves disguised as others to the affected person. Theories of delusional misidentification have suggested secondary (“organic”) underlying mechanisms; however, the pathoetiology of Fregoli syndrome has not been systematically evaluated. The investigators aimed to compare the neuropsychiatric
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A Systematic Review of Fragile X–Associated Neuropsychiatric Disorders J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-09-29 Joshua Flavell, Catherine Franklin, Peter J. Nestor
Objective: Fragile X premutation carriers are reported to have increased neuropsychiatric problems, and thus the term fragile X–associated neuropsychiatric disorders (FXAND) has been proposed. Unfortunately, published prevalence estimates of these phenomena are inconsistent. This systematic review clarified this issue by reviewing both fragile X premutation prevalence in patients with neurodevelopmental
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Neuroimaging in the Acute Psychiatric Setting: Associations With Neuropsychiatric Risk Factors J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-09-21 Katelyn Tadd, Thomas Rego, Frank Gaillard, Charles B. Malpas, Mark Walterfang, Dennis Velakoulis, Sarah Farrand
Objective: The appropriateness and clinical utility of neuroimaging in psychiatric populations has been long debated, and the ambiguity of guideline recommendations is well established. Most of the literature is focused on first-episode psychosis. The investigators aimed to review ordering practices and identify risk factors associated with neuroradiological MRI abnormalities and their clinical utility
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Cumulative Effect of Head Injuries on Nonmotor Outcomes in Parkinson’s Disease J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-09-21 Jacob D. Jones, Holly Timblin, Fawn Baxter
Objective: Parkinson’s disease (PD) is a neurodegenerative movement disorder that is a result of dopamine depletion in the basal ganglia. Individuals with a PD diagnosis experience motor symptoms (e.g., tremors) and nonmotor symptoms (e.g., cognitive decline). Previous studies suggest that progression of cognitive dysfunction in other neurologic populations can be predicted by cumulative head injuries
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Anti-N-Methyl-d-Aspartate Receptor Antibody Testing in First-Episode Psychosis: Universal or Targeted Testing J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-09-21 Sarah L. Cohn, Adith Mohan, Julia M. Lappin, Jackie Curtis, James G. Scott
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an immune-mediated disorder that typically presents with rapid development of neuropsychiatric symptoms. As a potentially reversible cause of psychosis, there have been calls internationally for routine serological screening for anti-NMDAR antibodies in patients presenting with first-episode psychosis (FEP). Increased serological testing has
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Apathy and Depression in Huntington’s Disease: Distinct Longitudinal Trajectories and Clinical Correlates J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-09-21 Michael H. Connors, Armando Teixeira-Pinto, Clement T. Loy
Objective: Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease resulting in motor disturbances, dementia, and psychiatric symptoms. Apathy is a common manifestation and rated as one of the most impactful by patients and caregivers. It can often be difficult to distinguish from depression because of shared features and frequent overlap. This study examined the longitudinal trajectories
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Novel Psychiatric Disorder 6 Months After Traumatic Brain Injury in Children and Adolescents J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 Jeffrey E. Max, Imogen Drake, Florin Vaida, John R. Hesselink, Linda Ewing-Cobbs, Russell J. Schachar, Sandra B. Chapman, Erin D. Bigler, Elisabeth A. Wilde, Ann E. Saunders, Tony T. Yang, Olga Tymofiyeva, Harvey S. Levin
Objective: To investigate the factors predictive of novel psychiatric disorders in the interval 0–6 months following traumatic brain injury (TBI). Methods: Children ages 5–14 years consecutively hospitalized for mild to severe TBI at five hospitals were recruited. Participants were evaluated at baseline (soon after injury) for pre-injury characteristics including psychiatric disorders, socioeconomic
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Higher Health Service Costs Associated With Delayed Diagnosis of Functional Neurological Disorder J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 Sofia Cuoco, Sara Scannapieco, Imma Carotenuto, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone, Roberto Erro
Objective: Functional neurological disorder (FND) is frequently encountered in clinical practice but commonly misdiagnosed, which might lead to higher direct costs for the health care system. The investigators analyzed the direct costs associated with the diagnosis of FND compared with costs associated with other neurological conditions and explored possible cost trends related to the clinical and
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Predictors of Treatment Response to a Psychoeducational Intervention for Anger in Chronic Moderate-Severe Traumatic Brain Injury J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 Tessa Hart, Roland D. Maiuro, Jesse R. Fann, Monica J. Vaccaro, Inna Chervoneva
Objective: The investigators examined predictors of treatment response to anger self-management training (ASMT) among patients with chronic moderate-severe traumatic brain injury (TBI). Methods: A multicenter randomized clinical trial comprising 90 participants with moderate-severe TBI was conducted. Fifty-four participants who were randomly assigned to receive active treatment and provided complete
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Addenbrooke’s Cognitive Examination–Third Edition Predicts Neuropsychological Test Performance J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 Giuliana V. Zarrella, Christina D. Kay, Katelyn Gettens, Janet C. Sherman, Mary K. Colvin
Objective: Effective screening tools can help providers with treatment decisions, including when to refer patients for neuropsychological evaluations, which are the gold standard for cognitive assessment of neurodegenerative disease. The authors examined whether performance on the Addenbrooke’s Cognitive Examination–Third Edition (ACE-III), a readily available cognitive screening tool for older adults
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Incongruences Between Facial Expression and Self-Reported Emotional Reactivity in Frontotemporal Dementia and Related Disorders J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 Peter S. Pressman, Kuan Hua Chen, James Casey, Stefan Sillau, Heidi J. Chial, Christopher M. Filley, Bruce L. Miller, Robert W. Levenson
Objective: Emotional reactivity normally involves a synchronized coordination of subjective experience and facial expression. These aspects of emotional reactivity can be uncoupled by neurological illness and produce adverse consequences for patient and caregiver quality of life because of misunderstandings regarding the patient’s presumed internal state. Frontotemporal dementia (FTD) is often associated
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The Carriers: What the Fragile X Gene Reveals About Family, Heredity, and Scientific Discovery. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 James A Bourgeois
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Headache-Associated Phantosmia as a Harbinger of Lewy Body Dementia. J. Neuropsychiatry Clin. Neurosci. (IF 2.9) Pub Date : 2022-08-22 Tara C Carlisle,Marius Birlea,Diego Restrepo,Christopher M Filley