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Two similar carbon monoxide poisoning cases with different outcomes: evidence from longitudinal fMRI Neurocase (IF 0.8) Pub Date : 2024-02-26 Ran Li, Yong Wang, Haidong Li, Jie Liu, Sujuan Liu
Prognosis after carbon monoxide (CO) poisoning is difficult to assess using structural images. Functional connectivity provided by functional magnetic resonance imaging (fMRI) may explain the mecha...
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Neglecting the bottom space: an object-based disorder? A two-case observational study Neurocase (IF 0.8) Pub Date : 2024-02-26 Jennifer Martin, Patrik Vuilleumier, Frédéric Assal, Roberta Ronchi
Altitudinal neglect is an atypical form of spatial neglect where brain-damaged patients neglect the lower, or sometimes the upper, part of the space. Our understanding of this phenomena is limited,...
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Diabetic striatopathy: a case report Neurocase (IF 0.8) Pub Date : 2024-02-17 Yi Guan, Lu Yuan, Lei Yuan
Diabetic striatopathy, a rare condition also known as hyperglycemic nonketotic hemichorea, is characterized by chorea or hemiballismus and distinctive basal ganglia abnormalities visible on neuroim...
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Epstein–Barr virus infection with non-tumor-associated Anti-N-Methyl-D-Aspartate receptor encephalitis: a case report and review of literature Neurocase (IF 0.8) Pub Date : 2023-12-16 Yan-Jun Ma, Lei Zhao, Jie-Qiong Li, Liu Yang, Yue-Ming Yan, Jiang-Bo Li, Li-Hong Gao
To study a case of a middle-aged male with a non-tumor-associated Epstein–Barr virus (EBV) infection associated with Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE), to explore the role of...
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Electroconvulsive therapy for obsessive compulsive symptoms in a patient with schizophrenia: a brief report Neurocase (IF 0.8) Pub Date : 2023-12-16 Chih-Yuan Lin, Hsin-Ya Kuo, Cheng-Ho Chang, Chih-Chuan Pan, Che-Sheng Chu, Jeremy Couper, Yung-Chih Chiang
Comorbid obsessive-compulsive disorder (OCD) is common among patients with schizophrenia. The role of electroconvulsive therapy (ECT) in the treatment of OCD in schizophrenia is unclear. Herein, we...
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Ictal religious speech in non-dominant temporal lobe epilepsy: three cases Neurocase (IF 0.8) Pub Date : 2023-12-16 Dilara Mermi Dibek, Pınar Tamer Çoban, Sevgi Ferik, İ̇brahim Öztura, Barış Baklan
Ictal religious speech and gestures, rare ictal semiological findings, sign the epileptic focus at the non-dominant temporal lobe in the literature. Therefore, we aim to present non-dominant tempor...
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A case report of acquired synesthesia and heightened creativity in a musician after traumatic brain injury Neurocase (IF 0.8) Pub Date : 2023-05-07 Rima Abou-Khalil, Lealani Mae Y. Acosta
We report on a musician who acquired synesthesia, enhanced sensory experience, and improved creativity following traumatic brain injury (TBI).Creativity and synesthesia can be acquired from an inju...
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Intracranial investigation of piriform cortex epilepsy during odor presentation Neurocase (IF 0.8) Pub Date : 2023-04-06 Donald J. Bearden, Robyn Selawski, Joshua J. Chern, Eva Del Valle Martinez, Sonam Bhalla, Ruba Al-Ramadhani, Kim E. Ono, Nigel P. Pedersen, Guojun Zhang, Daniel L. Drane, Ammar Kheder
The piriform cortex (PC) is part of the olfactory system, principally receiving input from the lateral olfactory tract and projecting to downstream components of the olfactory network, including th...
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Behavioral variant frontotemporal dementia in a 23-year-old man Neurocase (IF 0.8) Pub Date : 2023-03-30 Tania C. Ghazarian, Matthew G.H. Hall, Leslie A. Horton, Bruce L. Miller, Robert T. Rubin
A 23-year-old man presented with behavioral disinhibition, stereotypies, motor apathy, flattened affect, and inappropriate laughter. CT demonstrated generalized cerebral atrophy. He was admitted wi...
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Clinical, electrophysiological, and genetic characteristics of cerebrotendinous xanthomatosis in South Korea Neurocase (IF 0.8) Pub Date : 2023-02-19 Sunyoung Kim, Jin-Sung Park, Jae-Hyeok Lee, Ha-Young Shin, Hui-Jun Yang, Jin-Hong Shin
ABSTRACT Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disorder caused by 27-hydroxylase deficiency. We report the clinical characteristics of six Korean CTX patients. The median age of onset was 22.5 years, the median age at diagnosis was 42 years, and the diagnostic delay was 18.1 years. The most common clinical symptoms were tendon xanthoma and spastic paraplegia.
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Partial Balint’s syndrome and left homonymous hemianopsia presenting after resection of a right occipito-parietal glioblastoma Neurocase (IF 0.8) Pub Date : 2023-02-15 Petra Aboulhosn, Andrew Ryu, Azadeh Shafieesabet, Anusha Lekshminarayanan, Sohni Husain, Kathryn O’Connor, Saarah D’Souza, Shannon O’Neill, Eric L Altschuler
ABSTRACT A 66-year-old left-handed male was admitted to our acute inpatient rehabilitation (AIR) unit following a resection of the right occipito-parietal glioblastoma. He presented with symptoms of horizontal oculomotor apraxia, contralateral optic ataxia and left homonymous hemianopsia. We diagnosed this patient with partial Bálint’s syndrome (BS)— oculomotor apraxia, optic ataxia but not simultanagnosia
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Epilepsy or neurodevelopmental disorders are associated with homozygous and pathogenic ELP2 variation in three siblings Neurocase (IF 0.8) Pub Date : 2023-02-14 Dovlat Khalilov, Garen Haryanyan, Baris Salman, Emrah Yucesan, Sibel Ugur Iseri, Nerses Bebek
ABSTRACT Developmental and Epileptic Encephalopathies (DEEs) are a group of early-onset syndromic disorders characterized by varying degree of intellectual disability, autism spectrum, seizures, and developmental delay. Herein, we have clinically and genetically dissected three siblings from Turkey with DEE born to first cousin unaffected parents. We identified a homozygous pathogenic variant in ELP2
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A multimodal imaging approach to foreign accent syndrome. A case report Neurocase (IF 0.8) Pub Date : 2023-01-22 Greta Demichelis, Dunja Duran, Giuseppe Ciullo, Lorenzo Lorusso, Stefano Zago, Sara Palermo, Anna Nigri, Matilde Leonardi, Maria Grazia Bruzzone, Davide Fedeli
ABSTRACT This article describes a case of Foreign accent syndrome (FAS) in an Italian woman who developed a Canadian-like foreign accent without brain damage (functional FAS). The patient underwent an in-depth neuroimaging and (neuro)psychological evaluation. Language networks in the frontotemporal-parietal areas were typically activated bilaterally through fMRI and MEG assessments based on task-based
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A pilot study of olfactory function in veterans with a history of deployment-related mild traumatic brain injury Neurocase (IF 0.8) Pub Date : 2022-12-28 Maya Troyanskaya, Nicholas J. Pastorek, Fariha Jamal, George R. Jackson, Aliya I. Sarwar, Elisabeth A. Wilde, Randall S. Scheibel
ABSTRACT Olfactory impairment in military populations is highly prevalent and often attributed to the long-term effects of mild traumatic brain injury (mTBI) and chronic psychiatric disorders. The main goal of this investigation was to examine olfactory function in a cohort of combat veterans using a quantitative smell test. Participants underwent a neurological examination, completed performance validity
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The brain activation of anxiety disorders with emotional stimuli—an fMRI ALE meta-analysis Neurocase (IF 0.8) Pub Date : 2022-12-22 Xia Liu, Guowei Zheng, Xiuzhen Wang, Yongchao Li, Shanling Ji, Yu Zhang, Chaofan Yao, Yinghui Zhang, Bin Hu
ABSTRACT Numerous studies have analyzed the state of brain activation about anxiety disorders under emotional stimuli. However, there is no meta-analysis to assess the commonality and specificity activation concerning different subtypes of anxiety. Here, we used ALE to assess this. 29 studies revealed increased bilateral amygdala, anterior cingulate gyrus, parahippocampal gyrus activation in anxiety
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Examining the role of the uncinate fasciculus in proper noun naming: awake brain tumor resections and stereo EEG targeted electrical stimulation multiple case study Neurocase (IF 0.8) Pub Date : 2022-12-22 Jun Min Koay, Karen E. Blackmon, Erik H. Middlebrooks, Alfredo Quinones-Hinojosa, Kaisorn L Chaichana, Anteneh M. Feyissa, Sanjeet S. Grewal, David S. Sabsevitz
ABSTRACT While there is strong evidence from lesion and functional imaging studies implicating the left anterior temporal pole (LTP) in naming unique entities, less is known about white matter tracts in category-specific naming. We present evidence that implicates the uncinate fasciculus (UF) in proper noun naming. First, we describe two patients with left LTP gliomas who developed category specific
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Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology Neurocase (IF 0.8) Pub Date : 2022-11-30 Eleanor R. Palser, Zachary A. Miller, Abigail E. Licata, Nicole A. Yabut, Swati P. Sudarsan, Boon Lead Tee, Jessica A. Deleon, Maria Luisa Mandelli, Eduardo Caverzasi, Virginia E. Sturm, Robert Hendren, Katherine L. Possin, Bruce L. Miller, Maria Luisa Gorno Tempini, Christa Watson Pereira
ABSTRACT Diagnostic criteria for dyslexia describe specific reading difficulties, and single-deficit models, including the phonological deficit theory, have prevailed. Children seeking diagnosis, however, do not always show phonological deficits, and may present with strengths and challenges beyond reading. Through extensive neurological, neuropsychological, and academic evaluation, we describe four
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Treatment-resistant diabetic chorea manifesting with psychiatric symptoms: a case report Neurocase (IF 0.8) Pub Date : 2022-11-14 Tsubasa Miyauchi, Masami Yoshii, Takeo Oshima, Ken Tomotsune, Kazuhiro Tomiyasu
ABSTRACT We report a case of a 69-year-old man with treatment-resistant diabetic chorea presenting psychiatric symptoms. The right chorea lasted for 3 months and was refractory to control of diabetes mellitus or administration of haloperidol and benzodiazepines. Only administration of tiapride was efficacious. Magnetic resonance spectrometry and dopamine transporter-single photon emission computed
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Acute progressive large-area cerebral infarction caused by wasp sting: a case report Neurocase (IF 0.8) Pub Date : 2022-10-24 Liu Min, Zhang Wenning, Wang Wei, Wang Wei
ABSTRACT Acute renal failure, multiple organ failure, and allergic reactions caused by wasp sting have been reported in many clinical reports, however, there are few reports on cerebral infarction due to wasp sting. We report a patient who developed acute progressive cerebral infarction after wasp stings, suffered from left-sided hemiplegia, clumsy speech, and left facial droop, only left the MRC grade
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Later onset of Childhood Disintegrative Disorder (CDD): a case report Neurocase (IF 0.8) Pub Date : 2022-10-23 Silvia Di Vara, Silvia Guerrera, Giovanni Valeri, Stefano Vicari
ABSTRACT Childhood Disintegrative Disorder (CDD) is a rare condition characterized by regression of developmental and behavioral functioning after a period of apparently normal development, with an age of onset around 4 years. CDD is not included within the latest edition of the Diagnostic and Statistical Manual of Mental Disorders. We present a case report of an 11-year-old male who achieved normal
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Proton pump inhibitors-induced psychiatric symptoms Neurocase (IF 0.8) Pub Date : 2022-10-21 Li Zhao, Dajiang Xie
ABSTRACT Proton pump inhibitors are widely used in cure of digestive tract diseases and drug-induced psychiatric symptoms are rare. In this study, we aim to investigate the presentations, diagnostic approaches, treatments and prognosis. We present one case of proton pump inhibitors-induced motor hallucination underwent drug withdrawal and recovery subsequently. Delirium Rating Scale and Hamilton Anxiety
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”This looks like a movie”: a case report of post-surgical amnesia Neurocase (IF 0.8) Pub Date : 2022-10-19 Ana Pozueta, María García-Martínez, María Bravo, Carmen Lage, Sara López-García, Francisco Martínez-Dubarbie, Andrea Corrales-Pardo, María José Sedano-Tous, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez
ABSTRACT A 52-year-old male patient with a background of adaptive personality disorder was admitted for mitral valve repair and cardiac ablation for atrial fibrillation. He suffered intraoperative complications with severe mitral insufficiency that suffered ischemia.. Post-operatively, he demonstrated acute loss of retrograde autobiographical memory, prosopagnosia and a loss of public semantic memory
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Clinical, radiologic, and pathologic features of the globular glial tauopathy subtype of frontotemporal lobar degeneration in right temporal variant frontotemporal dementia with salient features of Geschwind syndrome Neurocase (IF 0.8) Pub Date : 2022-10-17 Sylvia Josephy-Hernandez, Michael Brickhouse, Samantha Champion, David Dongkyung Kim, Alexandra Touroutoglou, Matthew Frosch, Bradford C. Dickerson
ABSTRACT Globular Glial Tauopathy (GGT) is a rare form of Frontotemporal Lobar Degeneration (FTLD) consisting of 4-repeat tau globular inclusions in astrocytes and oligodendrocytes. We present the pathological findings of GGT in a previously published case of a 73-year-old woman with behavioral symptoms concerning for right temporal variant frontotemporal dementia with initial and salient features
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Very early-onset behavioral variant frontotemporal dementia in a patient with a variant of uncertain significance of a FUS gene mutation Neurocase (IF 0.8) Pub Date : 2022-10-13 Cristiano Schaffer Aguzzoli, Petronilla Battista, Rafi Hadad, Yuri Ferreira Felloni Borges, Lucas Porcello Schilling, Bruce L Miller
ABSTRACT The behavioral variant of Frontotemporal dementia (bvFTD) has typically a progressive course with cognitive and behavioral changes that manifests between 50 and 70 years. Very early-onset bvFTD with rapid progression is a rare syndrome under the frontotemporal lobar degeneration (FTLD) umbrella that has been associated with a variety of protein deposition and genetic mutations. We present
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A teenager with combined methylmalonic aciduria and homocystinuria (CblC type) presenting with neurological symptoms and congenital heart diseases: a case report Neurocase (IF 0.8) Pub Date : 2022-10-11 Li Zhou, Qin Yang
ABSTRACT Combined methylmalonic acidemia and homocystinuria, is a rare autosomal recessive disorder due to defective intracellular cobalamin metabolism. We report an 18-year-old Chinese male who presented with hypermyotonia, seizures, and congenital heart diseases. Mutation analysis revealed c.365A>T and c.482 G>A mutations in the MMACHC gene, diagnosed with methylmalonic aciduria and homocystinuria
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Visuomotor misalignment induced through immersive virtual reality to improve spatial neglect: a case-series study Neurocase (IF 0.8) Pub Date : 2022-10-11 Peii Chen, Olga Boukrina, Denise Krch
ABSTRACT One evidence-based treatment for spatial neglect is prism adaptation (PA) treatment. PA after-effects, i.e., the implicit shifts in the arm reaching position toward the neglected side of space after prism removal, are considered fundamental to PA treatment effects. In the present study, the arm reaching position was shifted through a visuomotor misalignment procedure using immersive virtual
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A 1p31.3 deletion encompassing the nuclear factor 1A gene presenting as possible temporal lobe epilepsy in association with schizoaffective disorder Neurocase (IF 0.8) Pub Date : 2022-10-09 Mark A. Colijn, Monica Hrynchak, Chantelle T. Hrazdil, Veerle Willaeys, Randall F. White, Robert M. Stowe
ABSTRACT Chromosome 1p32-p31 deletion syndrome, which is characterized by a variety of neurodevelopmental abnormalities, is thought to occur as a result of nuclear factor 1A (NFIA) haploinsufficiency. We present a case of a right-handed 40-year-old female with a 1p31.3 deletion, who exhibited numerous common features of this syndrome, in addition to treatment resistant schizoaffective disorder and
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Better conversations: a language and communication intervention for aphasia in posterior cortical atrophy Neurocase (IF 0.8) Pub Date : 2022-09-21 A. Volkmer, C Farrington-Douglas, Sj Crutch, S Beeke, Jd Warren, Kxx Yong
ABSTRACT Posterior cortical atrophy (PCA) describes a neurodegenerative syndrome characterized by progressive difficulties in cortical visual and other posterior cortical functions consistent with parieto-occipital and occipito-temporal involvement. It is increasingly recognized that many patients develop difficulties with other aspects of daily living, in particular, with language and communication
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Cortical activity involved in perception and imagery of visual stimuli in a subject with aphantasia. An EEG case report Neurocase (IF 0.8) Pub Date : 2022-09-14 Mariano Furman, Pablo Fleitas-Rumak, Pilar Lopez-Segura, Martín Furman, Gustavo Tafet, Gabriel A. de Erausquin, Tomás Ortiz
ABSTRACT Aphantasia has been described as the inability to voluntarily evoke mental images using the “mind’s eye.” We studied a congenital aphantasic subject using neuropsychological testsand 64 channel EEG recordings, in order to studycortical activity involved in perception and imagery evaluating event-related potentials(N170, P200, N250). The subject is in the normal range of the neuropsychological
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Chronic hematoma superimposed to a large frontotemporal arachnoid cyst: evidence against crowding of audioverbal memory Neurocase (IF 0.8) Pub Date : 2022-09-03 Panayiotis Patrikelis, Stefanos Korfias, Lambros Messinis, Alexandros Kossivas, Christina Zournatzidi, Athanasia Alexoudi, Giuliana Lucci, Stylianos Gatzonis, Grigorios Nasios
ABSTRACT We report a patient with a chronic subdural/epidural hematoma superimposed to a large arachnoid cyst occupying the left frontotemporal region. Both were discovered accidentally because of a trigeminal neuralgia and concomitant subjective memory complaints. Patient’s sudden selective audioverbal memory impairment probably links to a primary cortical tone deregulation and expressed through deficits
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ONE-TIME PAROXYSM of ARTISTIC TALENT in FOCAL EPILEPSY Neurocase (IF 0.8) Pub Date : 2022-08-28 Sreya Malladi, Kenneth Heilman, Giridhar Kalamangalam
ABSTRACT Despite having unremarkable artistic talent, an 8-year-old male with chronic focal epilepsy from the right lateral frontal lobe drew a complex visual pattern during a 15-minute spell when he looked physically unwell. He underwent epilepsy surgery shortly thereafter and has been seizure-free since. In the ensuing 16 years of follow-up there have been no other such artistic incidents. We deduce
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Combination therapy of modified electroconvulsive therapy and long-acting injectable aripiprazole for dopamine supersensitivity psychosis: a case report Neurocase (IF 0.8) Pub Date : 2022-08-21 Yusuke Matsuzaka, Manabu Noguchi, Shigeki Kanamura, Kengo Maeda, Takahiro Hisano, Daizo Tanaka, Yukihiro Ando, Tomokazu Yamamoto, Yoshiro Morimoto, Hiroki Ozawa, Toshihiro Otsuka
ABSTRACT In the treatment of schizophrenia, long-term pharmacotherapy with D2-receptor antagonists can induce dopamine supersensitivity psychosis (DSP). We report a male patient with schizophrenia with suspected DSP due to excessive polypharmacy. He was hospitalized for several years. Most psychotropic drugs were reduced and subsequently stopped without the exacerbation of symptoms by administering
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Community-based practical behavioral intervention in public transportation for people with acquired brain injury: study of two cases using a single-case experimental design study Neurocase (IF 0.8) Pub Date : 2022-08-01 Daisuke Shimizu, Tomoko Miyahara, Rumi Tanemura
ABSTRACT The purpose of this paper was to report on the progress of a behavioral approach to enable patients with acquired brain injury (age 57, male, stroke and age 36, old, female, TBI) using a community activity support center to commute alone using public transportation. In this study, two ABI patients were intervened to enable them to use public transportation. The frequency of intervention was
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A case of new cognitive changes in a patient with seronegative paraneoplastic limbic encephalitis: encephalitis relapse or Wernicke’s encephalopathy? Neurocase (IF 0.8) Pub Date : 2022-07-30 Li Zhang, Amir Adeli
ABSTRACT Wernicke’s encephalopathy (WE) and paraneoplastic limbic encephalitis (PLE) can both present with acute-to-subacute memory impairment and cognitive dysfunction. Both can lead to significant morbidity and mortality without rapid identification and treatment. Often patients with WE may not have the typical clinical triad of ophthalmoplegia, gait ataxia, and altered mental status. Furthermore
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“Split-day syndrome”, a patient with frontotemporal dementia who lives two days in the span of one: a case report and review of articles Neurocase (IF 0.8) Pub Date : 2022-07-28 Homa Pourriyahi, Mostafa Almasi-Dooghaee, Atefeh Imani, Taravat Vahedi, Babak Zamani
ABSTRACT Frontotemporal dementia (FTD) is among the most prevalent causes of young-onset dementia . Along with the frontotemporal and striate atrophy, dopamine dysregulation is also present in FTD. The dopamine system controls mechanisms of time perception. Its depletion can cause miscalculations in the perception of time. We present a 72-year-old man with a unique profile of disorientation in time
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Effect of motor tasks with left monocular eyeglasses on visual search and line-bisection performance in people with left unilateral spatial neglect Neurocase (IF 0.8) Pub Date : 2022-07-20 Sachiko Fujimori, Kei Tabaru, Yoshiyuki Kawano
ABSTRACT Training with an eyepatch or eyeglasses is one of the effective approaches for unilateral spatial neglect (USN), and it usually uses a device that covers the right side. However, few approaches are available for the left side. In this study, we examine the effect of motor tasks with left/right monocular eyeglasses on visual search and line-bisection performance in people with left USN. Seven
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A four-month home-based tDCS study on patients with Alzheimer’s disease Neurocase (IF 0.8) Pub Date : 2022-07-19 Ole K Grønli, Ingrid Daae Rasmussen, Per M Aslaksen, Martin Bystad
ABSTRACT In the present open-label study, our first aim was to study the tolerability and feasibility of long-term treatment with transcranial direct current stimulation (tDCS) and the second aim was to measure whether the treatment led to cognitive improvement. Participants with AD used a tDCS home-treatment kit inducing a low current (2 mA) via two scalp electrodes 30 minutes daily for 4 months.
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FUS as a cause of familial Amyotrophic lateral sclerosis, a case report in a pregnant patient Neurocase (IF 0.8) Pub Date : 2022-07-13 Lisette Bazán-Rodríguez, Jesús A. Ruíz-Avalos, Oscar Bernal-López, Edmar O. Benitez-Alonso, Jesica Villaseñor-Sánchez, Francisca Fernandez-Valverde, Steven Vargas-Cañas
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. In 10% the disease is familial and rarely occurs in childbearing age women. A 28-year-old female pregnancy patient presented a two-month history of dropped head syndrome, dysphagia, muscle weakness, atrophy, and lingual wasting. Electromyography supported the diagnosis of ALS. Due to family history and background, we carried
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Pupillometry as an index for cognitive processing in behavioral variant FrontoTemporal Dementia: a series of case studies Neurocase (IF 0.8) Pub Date : 2022-06-29 Mohamad El Haj, Dimitrios Kapogiannis, Claire Boutoleau-Bretonnière
ABSTRACT We investigated whether pupil size can variate with the intensity of cognitive processing in patients with behavioral-variant-Frontotemporal-Dementia (bvFTD). We invited five bvFTD participants and 21 controls to perform forward spans and backward spans, and, in a control condition, to count aloud. We recorded pupil activity using eye-tracking-glasses during the spans and control condition
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Prosopamnesia: a case report of amnesia for faces Neurocase (IF 0.8) Pub Date : 2022-06-13 Stefano Merolla, Monica Borella, Ignazio Michele Santilli, Maria Pia Grassi
ABSTRACT Prosopamnesia is a face-selective memory disorder in which face learning is impaired, while face-perception disorder (prosopagnosia) and memory disorders for stimuli other than faces are not present. To date, only two cases of prosopamnesia have been reported in adults – one congenital and one secondary to brain damage. This article reports a case of a 68-year-old woman complaining difficulties
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Understanding and management of anti-N-methyl-D-aspartate receptor encephalitis from a child psychiatry perspective: report of five cases Neurocase (IF 0.8) Pub Date : 2022-06-07 Nurhak Dogan, Hilal Subasi, Zeynep Irem Erbasan, Akin Tahillioglu, Seda Kanmaz, Sezen Kose, Burcu Ozbaran, Hepsen Mine Serin
ABSTRACT Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a rare autoimmune entity in psychiatry literature that occurs when antibodies attack NMDA-type glutamate receptors in the brain. Principle clinical features include a neurological domain such as seizure, orofacial dyskinesia, dystonia, and choreic-like movements of extremities. Also the psychiatric manifestations of this form
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A novel GALC gene mutation associated with adult-onset Krabbe disease: a case report Neurocase (IF 0.8) Pub Date : 2022-06-02 Zhengqing He, Xinyuan Pang, Jiongming Bai, Haoran Wang, Feng Feng, Rongrong Du, Xusheng Huang
ABSTRACT To analyze the clinical, imaging, and genetic characteristics of a patient diagnosed with adult-onset Krabbe disease (KD). Clinical and imaging features of the patient were retrospectively reviewed. The patient, a 40-year-old female, presented adult-onset spastic paraplegia. Brain magnetic resonance imaging (MRI) showed white matter hyperintensities along bilateral optic radiations. Colorimetry
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Neuralgic amyotrophy triggered by cytomegalovirus: to be aware of this clinical diagnosis Neurocase (IF 0.8) Pub Date : 2022-06-02 Quentin Scanvion, Sandrine Morell-Dubois
ABSTRACT Neuralgic amyotrophy (NA) is a multifocal inflammatory neuropathy. Although the exact etiopathogenesis of the latter is unknown, the literature reports frequent associations with immunological events such as different infectious diseases. Our case reveals a rarely described etiology of NA. NA is mainly a clinical diagnosis. The etiology shown in our case study is interesting for the scientific
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Ictal paraphasia as an atypical manifestation of temporal lobe epilepsy Neurocase (IF 0.8) Pub Date : 2022-05-24 Jorge Barragán-Ardila, Luis Carlos Mayor, Julián Mancera, Paula Martínez Micolta
ABSTRACT Language disturbances are common manifestations of non-convulsive seizures in focal epilepsy. Ictal aphasia and speech arrest are the most representative. On the other hand, ictal paraphasia is a rare clinical manifestation of dominant temporal lobe epilepsy, with few cases reported in the literature. We describe a 73-year-old woman with focal onset unaware seizures presenting with phonemic
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Noninvasive stimulation of the unlesioned hemisphere and phonological treatment in a case of chronic anomia post-stroke Neurocase (IF 0.8) Pub Date : 2022-05-17 Noémie Comeau, Laura Monetta, Cyril Schneider
ABSTRACT Chronic lexical anomia after left hemisphere (LH) stroke improves under personalized phonological treatment (PT). Cortical linking between language and hand motor areas (hand_M1) questioned whether PT-related improvement relies on the unlesioned hemisphere (UH) plasticity when LH is dysfunctional. Our 70-yo-woman case study showed that 10 sessions of excitatory stimulation of UH_hand-M1 combined
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Neuropsychological functioning in childhood cancer survivors following cranial radiotherapy – results from a long-term follow-up clinic Neurocase (IF 0.8) Pub Date : 2022-05-12 Isabelle Rydén, Erik Fernström, Birgitta Lannering, Marie Kalm, Malin Blomstrand, Per Hellström, Thomas Björk-Eriksson, Marianne Jarfelt
ABSTRACT Treatment of malignant childhood posterior fossa tumors (CPFT) often includes surgical resection and craniospinal radiotherapy (CSI). Nasopharyngeal tumors in childhood (CNPHT) are often treated with surgery and radiotherapy (RT), leading to incidental brain irradiation. RT to the developing brain is associated with risks for cognitive impairments. We studied cognitive functioning, health-related
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Efficacy of transcranial Direct Current Stimulation (tDCS) combined with intensive speech therapy for language production in monozygotic twins with corpus callosum dysgenesis (CCD): A sham-controlled single subject study Neurocase (IF 0.8) Pub Date : 2022-05-09 Najva Mousavi, Michael A. Nitsche, Ali Jahan, Mohammad Ali Nazari, Hassan Hassanpour
ABSTRACT The purpose of this single subject study was to investigate whether transcranial direct current stimulation (tDCS) applied to both hemispheres combined with speech therapy can improve language learning in a pair of 5-year-old twins with corpus callosum dysgenesis (CCD). The treatment protocol included anodal tDCS with simultaneous speech therapy in one of the participants (T.D.), and sham-tDCS
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Sleep macro- and micro-structure in autoimmune encephalitis: single case report from the subacute phase of the disease to the follow-up Neurocase (IF 0.8) Pub Date : 2022-05-08 Carlotta Mutti, Marco Cesare Angeli, Francesco Rausa, Valentina Tontini, Silvia Pizzarotti, Margherita Soglia, Irene Pollara, Clara Rapina, Nicoletta Azzi, Lucia Zinno, Liborio Parrino
ABSTRACT Sleep disorders are frequently described in autoimmune encephalitis (AE); however, data on sleep texture are fragmentary. We analyzed the polysomnography of a woman affected by AE, and we performed cyclic alternating pattern (CAP) scoring during the subacute phase of the disease and at follow-up. The first polysomnography showed deviations both at macro and microstructure levels, with a marked
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Reflected image processing abnormalities in dementia – a case series and review Neurocase (IF 0.8) Pub Date : 2022-05-08 Thomas Gregor Issac, Shiv Shanker Reddy Mukku, Sandhya Mangalore, Preeti Sinha, Palanimuthu T. Sivakumar
ABSTRACT Dementia is a neurodegenerative condition with progressive decline in cognitive faculties and associated with different clinical phenomena. Mirror phenomenon in terms of both mirror agnosia and mirror image agnosia wherein there is difficulty in processing and perception of reflected images is not uncommonly seen, and understanding the same can contribute to early diagnosis and prognostication
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Hyperparathyroidism and cerebral calcifications:a case report Neurocase (IF 0.8) Pub Date : 2022-05-03 Hongyan Xu, Haoqiang Qin, Shengwu Zhong, Qitan He, Shaohua Chen, Mingjian Guan
ABSTRACT The evidence of hyperparathyroidism associated with cerebral calcifications is rare. We report a case with primary hyperparathyroidism (PHPT) and cerebral calcifications. A 63-year-old female patient with a history of hypertension presented to the neurology department due to bradykinesia and declining memory for one year. Cranial CT and magnetic resonance imaging (MRI) scan revealed symmetrical
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Pathogenicity analysis and a novel case report of intronic mutations in CSF1R gene Neurocase (IF 0.8) Pub Date : 2022-05-03 Xue Shixing, Wang Wei, Hou Xueyan, Tang Wei
ABSTRACT Colony-stimulating factor 1 receptor-associated leukoencephalopathy (CSF1R-related leukoencephalopathy) is a genetic disorder mutated in a single allele. It is characterized by an adult-onset along with predominantly cognitive impairment, accompanied by neuropsychiatric symptoms as well as motor symptoms such as Parkinsonism. In the current study, we confirmed a case of CSF1R-related leukoencephalopathy
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Circumscribed supplementary motor area injury with gait apraxia including freezing of gait and shuffling gait: a case report Neurocase (IF 0.8) Pub Date : 2022-05-01 Takuya Yada, Tsubasa Kawasaki
ABSTRACT Clinical findings in cases of injury circumscribed with SMA is no consensus. We report the case of a 60-year-old male with circumscribed SMA injury who showed freezing of gait, and shuffling gait. Twenty-one days after onset, the patient showed difficulties with the left leg swing in gait initiation (freezing of gait). In steady-state gait, the stride of the left leg swing was short (shuffling
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A case of acquired phonological dyslexia with selective impairment of Kanji: analysis of reading impairment mechanism using cognitive neuropsychological models for reading Neurocase (IF 0.8) Pub Date : 2022-04-27 Shinji Uema, Akira Uno, Kosei Hashimoto, Ami Sambai
ABSTRACT We report a Japanese-speaking patient who showed acquired phonological dyslexia only in Kanji; difficulty in reading two-character Kanji nonwords despite her ability to read Kana nonwords, Kana words, and two-character Kanji inconsistent-atypical words; and inability to repeat reversal nonwords. We investigated the mechanism of nonword reading impairment using the dual-route cascaded model
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Effects of kinesthetic illusion induced by visual stimulation (KINVIS) therapy on patients with stroke in the subacute phase: a visual analysis based on paralysis severity Neurocase (IF 0.8) Pub Date : 2022-04-26 Megumi Okawada, Toru Inada, Naoki Matsuda, Seiji Motozawa, Masaki Yoneta, Shun Sasaki, Eriko Shibata, Fuminari Kaneko
ABSTRACT We explored the effect of kinesthetic illusion induced by visual stimulation (KINVIS) therapy on motor function in patients with stroke during the subacute phase based on paralysis severity. The study was performed using an ABAB design (A1, B1, A2, B2; for 10 days each). KINVIS therapy was additionally administered in periods B1 and B2. Ten patients with stroke were classified according to
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Wernicke encephalopathy with epileptic seizures during pregnancy Neurocase (IF 0.8) Pub Date : 2022-04-24 Tuğçe Mengi, Yeşim Beckmann
ABSTRACT A 22-year-old woman was admitted to the emergency department with headache, dizziness, and numbness on the left side of the body. Neurologic examination revealed gaze-evoked nystagmus. Cranial magnetic resonance imaging, venous and arterial magnetic resonance angiography were normal. Generalized epileptogenic activity was observed in the electroencephalography. The erythrocyte thiamine transketolase
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Walking through a narrow opening improves collision avoidance behavior in a patient with stroke and unilateral spatial neglect: an ABA single-case design Neurocase (IF 0.8) Pub Date : 2022-04-24 Daisuke Muroi, Yutaro Saito, Aki Koyake, Kazuhiro Yasuda, Takahiro Higuchi
ABSTRACT We investigated the effect of a 3-week intervention—wherein a patient with unilateral spatial neglect walks through a narrow opening while entering from the contralesional side—to improve walking ability or ADL. A 66-year-old man was diagnosed with right parietal subcortical hemorrhage. We used an ABA single-case design; period B was set as the intervention. The intervention improved the continuous
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Brain plasticity after rehabilitation in a severe case of artery of Percheron stroke assessed with multimodal MR imaging Neurocase (IF 0.8) Pub Date : 2022-04-24 E. Tavazzi, N. Bergsland, A. Pirastru, L. Pelizzari, M. Cazzoli, F.L. Saibene, J.S. Navarro, E. Farina, A Comanducci, P. Cecconi, F. Baglio
ABSTRACT Artery of Percheron (AOP) stroke is a rare event. We describe an AOP stroke involving both thalami and the midbrain, resulting in a multifunctional clinical impairment. Intensive inpatient multidisciplinary rehabilitation favored the recovery of motor deficits, together with the improvement of cognitive dysfunctions. MRI assessment in the chronic post-stroke phase showed structural and functional
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Benefit of cognitive behavioral therapy for post-traumatic stress disorder and obsessive-compulsive disorders in Huntington’s disease: a case report Neurocase (IF 0.8) Pub Date : 2022-04-24 M. Meyer, L Barreault, S. Frismand, C. Hingray
ABSTRACT We describe the management of post-traumatic stress disorder (PTSD) and obsessive-compulsive disorders (OCD), through Cognitive Behavioral Therapy (CBT) in a Huntington’s disease (HD) patient.Even with a psychopharmacological treatment to manage PTSD and OCD, psychiatric disorders remained in the HD patient. We proposed CBT essentially based on progressive exposure. The symptomatology disappeared
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A CASE OF MIGRAINE WITH SYMPTOMS OF PERCEPTION DISORDERS INCLUDING A FAMILY HISTORY Neurocase (IF 0.8) Pub Date : 2022-04-24 Çiğdem Tanrıverdi, İhsan Kara
ABSTRACT Alice in Wonderland Syndrome is characterized by distortions in perception, especially with signs of micropsia or macropsia, peropia, teleopsia.The etiology of this syndrome includes migraine attacks, epilepsy, infections or substance abuse.In this case study, a 15-year-old adolescent girl was admitted to our child and adolescent psychiatry clinic with complaints of seeing objects and people
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The Role of the Insula in Classical and Dissociative PTSD: A Double Case Study Neurocase (IF 0.8) Pub Date : 2022-04-22 Robin Blades, Sergio Becerra, Sheldon Jordan, Branon Eusebio, Mark Heatwole, Jessica Iovine, Kennedy Mahdavi, Michael Mamoun, Natalie Nicodemus, Hannah Packham, Norman Spivak, Taylor Kuhn
ABSTRACT Two service members were diagnosed with PTSD due to military trauma exposure. One presented with the classical manifestation; the other presented with the dissociative subtype. A statistical map revealed anterior localization of insula connectivity in the classical PTSD patient and posterior localization in the dissociative PTSD patient. These differences suggest that dissociative PTSD may