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Recent Advances in Clinical Trials in Multiple System Atrophy Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-02-28 David Bendetowicz, Margherita Fabbri, Federico Sirna, Pierre-Olivier Fernagut, Alexandra Foubert-Samier, Tiphaine Saulnier, Anne Pavy Le Traon, Cécile Proust-Lima, Olivier Rascol, Wassilios G. Meissner
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The Impact of Aging on Multiple Sclerosis Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-02-28 Christopher E. Goyne, Ashley E. Fair, Paige E. Sumowski, Jennifer S. Graves
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Interpretation of the Visual Field in Neuro-ophthalmic Disorders Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-01-30 Ana Banc, Sachin Kedar
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Cognitive, Emotional, and Other Non-motor Symptoms of Spinocerebellar Ataxias Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-01-25 Chi-Ying R. Lin, Sheng-Han Kuo, Puneet Opal
Purpose of Review Spinocerebellar ataxias (SCAs) are autosomal dominant degenerative syndromes that present with ataxia and brain stem abnormalities. This review describes the cognitive and behavioral symptoms of SCAs in the context of recent knowledge of the role of the cerebellum in higher intellectual function. Recent Findings Recent studies suggest that patients with spinocerebellar ataxia can
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Advantages and Pitfalls of the Use of Optical Coherence Tomography for Papilledema Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-01-23 Fiona Costello, Steffen Hamann
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Lobar Microbleeds in the Posterior Cortical Atrophy Syndrome: A Comparison to Typical Alzheimer’s Disease Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-01-23
Abstract Purpose of the study Posterior cortical atrophy is a clinico-radiographical syndrome that presents with higher-order visual dysfunction and is most commonly due to Alzheimer’s disease. Understanding factors associated with atypical presentations of Alzheimer’s disease, such as posterior cortical atrophy (PCA), holds promise to shape our understanding of AD pathophysiology. Thus, we aimed to
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Updated Response Assessment in Neuro-Oncology (RANO) for Gliomas Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2024-01-03 Gilbert Youssef, Patrick Y. Wen
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Magnetoencephalography for Epilepsy Presurgical Evaluation Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-12-27 Aaron S. Geller, Peter Teale, Eugene Kronberg, John S. Ebersole
Purpose of the Review Magnetoencephalography (MEG) is a functional neuroimaging technique that records neurophysiology data with millisecond temporal resolution and localizes it with subcentimeter accuracy. Its capability to provide high resolution in both of these domains makes it a powerful tool both in basic neuroscience as well as clinical applications. In neurology, it has proven useful in its
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Hormonal Therapies in Multiple Sclerosis: a Review of Clinical Data Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-12-16 Stephanie Hsu, Riley Bove
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Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-12-07 Wesley T. Kerr, Katherine N. McFarlane
Purpose of Review Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist
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Neural Control of REM Sleep and Motor Atonia: Current Perspectives Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-12-07 Ramalingam Vetrivelan, Sathyajit Sai Bandaru
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Exploring the Role of Locus Coeruleus in Alzheimer’s Disease: a Comprehensive Update on MRI Studies and Implications Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-12-08 Alessandro Galgani, Filippo Sean Giorgi
Purpose of Review Performing a thorough review of magnetic resonance imaging (MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer’s disease (AD), and contextualizing them with current preclinical and neuropathological literature. Recent Findings MRI successfully detected LC alterations in ageing and AD, identifying degenerative phenomena involving this nucleus even in the
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Vagus Nerve Stimulation in Ischemic Stroke Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-27 Sasan Andalib, Afshin A. Divani, Cenk Ayata, Sheharyar Baig, Ethem Murat Arsava, Mehmet Akif Topcuoglu, Eder Leonardo Cáceres, Vinay Parikh, Masoom J. Desai, Arshad Majid, Sara Girolami, Mario Di Napoli
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Neuromodulation for Post-Stroke Motor Recovery: a Narrative Review of Invasive of Invasive and Non‑Invasive Tools Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-28 Zafer Keser, Salman Ikramuddin, Shashank Shekhar, Wuwei Feng
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Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-24 Amritha Harikumar, Kseniya P. Solovyeva, Maria Misiura, Armin Iraji, Sergey M. Plis, Godfrey D. Pearlson, Jessica A. Turner, Vince D. Calhoun
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Sleep Duration and Executive Function in Adults Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-14 Aayushi Sen, Xin You Tai
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Recent Advances in Pediatric Medulloblastoma Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-09 Kasey Jackson, Roger J Packer
Purpose of Review Review recent advances in the understanding of pediatric medulloblastoma including etiology, biology, radiology, and management of pediatric medulloblastoma. Recent Findings The classic four subgroups have been reclassified and further subdivided based on new molecular findings. Research is revealing the cell origins of the different subtypes of medulloblastoma. There has been continued
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Autonomic Manifestations of Long-COVID Syndrome Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-10 Rashmin Hira, Kavithra Karalasingham, Jacquie R. Baker, Satish R. Raj
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Neurotoxicity of Cancer Immunotherapies Including CAR T Cell Therapy Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-08 Kun-Wei Song, Brian J. Scott, Eudocia Q. Lee
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Recent Developments in Blood Biomarkers in Neuro-oncology Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-09 Jessica B. Foster, Mateusz P. Koptyra, Stephen J. Bagley
Purpose of Review Given the invasive and high-risk nature of brain surgery, the need for non-invasive biomarkers obtained from the peripheral blood is greatest in tumors of the central nervous system (CNS). In this comprehensive review, we highlight recent advances in blood biomarker development for adult and pediatric brain tumors. Recent Findings We summarize recent blood biomarker development for
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Updates in Parkinson’s Disease Integrative Therapies: an Evidence-Based Review Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-03 Sushma Kola, Indu Subramanian
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Advances in Treatment of Diffuse Midline Gliomas Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-11-03 Chantel Cacciotti, Karen D. Wright
Purpose of Review Diffuse midline gliomas (DMGs) generally carry a poor prognosis, occur during childhood, and involve midline structures of the central nervous system, including the thalamus, pons, and spinal cord. Recent Findings To date, irradiation has been shown to be the only beneficial treatment for DMG. Various genetic modifications have been shown to play a role in the pathogenesis of this
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Disparities in Neuro-Oncology Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-27 Nara Miriam Michaelson, Amanda Watsula, Anu Bakare-Okpala, Maliheh Mohamadpour, Ugonma N. Chukwueke, Joshua A. Budhu
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Immune Checkpoint Inhibitors in Patients with Pre-existing Neurologic Autoimmune Disorders Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-23 Raissa Aoun, Daniel Gratch, David Kaminetzky, Ilya Kister
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Neurological Complications Associated with Hereditary Bleeding Disorders Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-21 Muhammad Qasim Bhatti, Ezekiel Gonzalez-Fernandez, Kunal Bhatia, Afshin A. Divani, Mario Di Napoli, Archana Hinduja, Yvonne H. Datta
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The Association Between Cognitive Domains and Postural Balance among Healthy Older Adults: A Systematic Review of Literature and Meta-Analysis Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-19 Nahid Divandari, Marie-Louise Bird, Mahdi Vakili, Shapour Jaberzadeh
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Sporadic Late-Onset Nemaline Myopathy: Current Landscape Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-19 Stefan Nicolau, Margherita Milone
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Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-17 Svetlana Blitshteyn
Purpose of Review Dysautonomia refers to the dysfunction of the autonomic nervous system and encompasses a wide variety of autonomic symptoms and disorders. The most common autonomic disorders are postural orthostatic tachycardia syndrome (POTS), neurocardiogenic syncope (NCS), and orthostatic hypotension (OH), which may be encountered in clinical practice as part of a triad of dysautonomia, hypermobility
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REM Behavior Disorder: Implications for PD Therapeutics Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-13 Jeanne S. Feuerstein, Amy Amara
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Post-stroke Everything Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-14 Alain Lekoubou, Clever Nguyen, Michelle Kwon, Arsene Daniel Nyalundja, Ankita Agrawal
Purpose of Review This review aims at providing updates on selected post-stroke complications. We examined recent advances in diagnosing and treating the following post-stroke complications: cognitive impairment, epilepsy, depression, fatigue, tremors, dysphagia, and pain. Recent Findings Advances in understanding the mechanisms of post-stroke complications, in general, are needed despite advances
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Molecular Profiling and Targeted Therapies in Gliomas Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-09 Yuli Felistia, Patrick Y. Wen
Purpose of Review Molecular profiling enables the evaluation of genetic alterations for the diagnosis and classification of gliomas and the selection of appropriate therapies. This review summarizes the current role of molecular profiling and targeted therapies for gliomas. Recent Findings Molecular profiling is an integral part of the 2021 WHO classification of gliomas. Progress in the development
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Pediatric Multiple Sclerosis: Changing the Trajectory of Progression Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-04 Daniela Castillo Villagrán, E. Ann Yeh
Purpose of Review Multiple sclerosis is a chronic inflammatory disease of the central nervous system. When seen in children and adolescents, crucial stages of brain development and maturation may be affected. Prompt recognition of multiple sclerosis in this population is essential, as early intervention with disease-modifying therapies may change developmental trajectories associated with the disease
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Exercise Made Accessible: the Merits of Community-Based Programs for Persons with Parkinson’s Disease Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-10-04 Anneli Langbroek-Amersfoort, Sabine Schootemeijer, Lars Bouten, Bastiaan R. Bloem, Nienke M. De Vries
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Palliative Care in Neuro-oncology: an Update Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-09-26 John Y. Rhee, Sumita Strander, Alyx Podgurski, Daniel Chiu, Kate Brizzi, Deborah A. Forst
Purpose of Review While the benefits of palliative care for patients with cancer are well established, palliative care in neuro-oncology is still in its early stages. However, in recent years, there has been increasing attention drawn to the need for better palliative care for patients with brain tumors. Recent Findings There is a growing body of literature demonstrating the high symptom burden and
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The Auditory Agnosias: a Short Review of Neurofunctional Evidence Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-09-25 Gabriele Miceli, Antea Caccia
Purpose of Review To investigate the neurofunctional correlates of pure auditory agnosia and its varieties (global, verbal, and nonverbal), based on 116 anatomoclinical reports published between 1893 and 2022, with emphasis on hemispheric lateralization, intrahemispheric lesion site, underlying cognitive impairments. Recent Findings Pure auditory agnosia is rare, and observations accumulate slowly
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The Financial Burden of Functional Neurological Disorders Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-09-11 Meagan Watson, Jared Woodward, Laura A. Strom
Purpose of Review Functional neurological disorder (FND) is a common and severely debilitating condition lacking clinical ownership, existing between neurology and psychiatry. This article reports the findings of recent research investigating the economic costs of FND diagnosis and management. We define what the costs are, why they exist, and suggest actionable steps to reduce them. Recent Findings
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Brain Sagging Dementia Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-09-07 Aslan Lashkarivand, Per Kristian Eide
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Sleep Disturbances in Autoimmune Neurological Diseases Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-09-06 Laura Pérez-Carbonell, Alex Iranzo
Purpose of Review To summarize the current evidence on the associations between autoimmune neurological diseases (e.g., multiple sclerosis, myasthenia gravis) and sleep disturbances (e.g., insomnia, parasomnias), as well as to review the main characteristics of sleep disorders with an immune-related pathophysiology (e.g., narcolepsy, anti-IgLON5 disease). Recent Findings An immune-mediated damage of
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Headache in COVID-19 and Long COVID: to Know Facts for Clinical Practice Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-09-04 Laura Gómez-Dabó, Laura Melgarejo-Martínez, Edoardo Caronna, Patricia Pozo-Rosich
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The Kinetics of Transtentorial Brain Herniation: Kernohan-Woltman Notch Phenomenon Revisited Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-23 Debasish Roy, Ambar Chakravarty
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Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-17 Alice Mariottini, Eleonora De Matteis, Maria Teresa Cencioni, Paolo A. Muraro
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An Update on Temporomandibular Disorders (TMDs) and Headache Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-15 Marcela Romero-Reyes, Gary Klasser, Simon Akerman
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Trigeminal Autonomic Cephalalgias and Neuralgias in Children and Adolescents: a Narrative Review Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-12 Ankita Ghosh, Leena Varghese, Mark J. Burish, Christina L. Szperka
Purpose of Review To summarize the available literature as well as the authors’ experience on trigeminal autonomic cephalalgias (TACs) and cranial neuralgias in children and adolescents. Recent Findings While TACs and cranial neuralgias are rare in children, several recent case series have been published. Summary TACs in children share most of the clinical features of TACs in adults. However, there
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Sleep and Perivascular Spaces Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-12 Brynn K. Dredla, Oscar H. Del Brutto, Pablo R. Castillo
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Lewy Body Dementia: An Overview of Promising Therapeutics Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-12 Irina A. Skylar-Scott, Sharon J. Sha
Purpose of Review Lewy body dementia (LBD) encompasses dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). This article will emphasize potential disease-modifying therapies as well as investigative symptomatic treatments for non-motor symptoms including cognitive impairment and psychosis that can present a tremendous burden to patients with LBD and their caregivers. Recent Findings
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A Clinical Approach to Existing and Emerging Therapeutics in Neuromyelitis Optica Spectrum Disorder Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-08-04 Heather Y. F. Yong, Jodie M. Burton
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Polypharmacy in Multiple Sclerosis: Prevalence, Risks, and Mitigation Strategies Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-07-31 W. Daniel Chapman, Megan C. Herink, Michelle H. Cameron, Dennis Bourdette
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Cognitive Aspects of COVID-19 Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-07-25 Ezekiel Gonzalez-Fernandez, Juebin Huang
Purpose of Review Since the beginning of the coronavirus disease 2019 pandemic, many lasting neurological sequelae including cognitive impairment have been recognized as part of the so-called long COVID syndrome. This narrative review summarizes the cognitive aspects of COVID-19. Recent Findings Studies have consistently identified attention, memory, and executive functions as the cognitive domains
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The Relationship Between Sleep, Epilepsy, and Development: a Review Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-07-17 Annie H. Roliz, Sanjeev Kothare
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Cognitive Interventions for Neurodegenerative Disease Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-07-10 Jason W. Krellman, Giulia Mercuri
Purpose of Review To critically review recent research in the development of non-pharmacological interventions to improve cognitive functioning in individuals with Alzheimer’s disease (AD) or Parkinson’s disease (PD). Recent Findings Cognitive interventions can be grouped into three categories: cognitive stimulation (CS), cognitive training (CT), and cognitive rehabilitation (CR). CS confers temporary
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Measuring Pathology in Patients with Multiple Sclerosis Using Positron Emission Tomography Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-07-07 Matthew R. Brier, Farris Taha
Purpose of Review Multiple sclerosis is characterized by a diverse and complex pathology. Clinical relapses, the hallmark of the disease, are accompanied by focal white matter lesions with intense inflammatory and demyelinating activity. Prevention of these relapses has been the major focus of pharmaceutical development, and it is now possible to dramatically reduce this inflammatory activity. Unfortunately
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Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-07-03 Diana L. Alsbrook, Mario Di Napoli, Kunal Bhatia, José Biller, Sasan Andalib, Archana Hinduja, Roysten Rodrigues, Miguel Rodriguez, Sara Y. Sabbagh, Magdy Selim, Maryam Hosseini Farahabadi, Alibay Jafarli, Afshin A. Divani
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Posterior Reversible Leucoencephalopathy Syndrome: Case Series, Comments, and Diagnostic Dilemma Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-28 Jasodhara Chaudhuri, Sagar Basu, Mrinal K Roy, Ambar Chakravarty
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The Role of Manual Therapies in the Treatment of Headache Disorders Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-24 Sheena Pillai, Niushen Zhang
Purpose of Review A comprehensive headache treatment plan typically requires both medication and non-medication treatment strategies. Manual therapies offer another therapeutic approach to headache treatment. This article reviews the evidence for manual therapies in the treatment of headache disorders. Recent Findings Current evidence shows potential benefit from myofascial trigger point injections
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Adult Attention-Deficit/Hyperactivity Disorder: a Narrative Review of Biological Mechanisms, Treatments, and Outcomes Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-19 Antonio F. Pagán, Yazmine P. Huizar, Tucker R. Short, Zoe Gotcher, Adam T. Schmidt
Purpose of Review Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous and complex neurodevelopmental disorder related to disruptions in various neuronal structures and pathways, dopamine (DA) transporter, and receptor genes, resulting in cognitive and regulation deficits. This article reviews recent research on the biological mechanisms and markers, clinical manifestations, treatments
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The Current of Consciousness: Neural Correlates and Clinical Aspects Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-12 Garrett Friedman, Katherine W. Turk, Andrew E. Budson
Purpose of Review In this review, we summarize the current understanding of consciousness including its neuroanatomic basis. We discuss major theories of consciousness, physical exam-based and electroencephalographic metrics used to stratify levels of consciousness, and tools used to shed light on the neural correlates of the conscious experience. Lastly, we review an expanded category of ‘disorders
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Supporting Post-Stroke Language and Cognition with Pharmacotherapy: Tools for Each Phase of Care Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-05 Melissa D. Stockbridge, Zafer Keser
Purpose of Review There is enormous enthusiasm for the possibility of pharmacotherapies to treat language deficits that can arise after stroke. Speech language therapy remains the most frequently utilized and most strongly evidenced treatment, but the numerous barriers to patients receiving the therapy necessary to recover have motivated the creation of a relatively modest, yet highly cited, body of
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Medication Overuse Headache: an Updated Review and Clinical Recommendations on Management Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-05 Megan A. Hird, Claire H. Sandoe
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Sleep Disorders in Patients with Choreic Syndromes Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-03 Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, José A.G. Agúndez
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An Update on Apraxia of Speech Curr. Neurol. Neurosci. Rep. (IF 5.6) Pub Date : 2023-06-03 Rene L. Utianski, Keith A. Josephs