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Olfactory threshold as a biomarker of long-term relapse activity in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Klaus Berek, Harald Hegen, Michael Auer, Robert Barket, Franziska Di Pauli, Jakob Hocher, Nik Krajnc, Anne Zinganell, Florian Deisenhammer, Thomas Berger, Gabriel Bsteh
Olfactory threshold (OT) is a marker of short-term inflammatory activity in multiple sclerosis (MS). To investigate whether OT predicts long-term MS clinical disease course. This was a 6-year prospective longitudinal study on MS patients at the MS clinic Innsbruck. Clinical visits assessing the occurrence of relapses, Expanded Disability Status Scale (EDSS) scores, and disease-modifying treatment (DMT)
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Multiple Sclerosis Multidisciplinary Care: a national survey and lessons for the global community Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Liesbeth Van Hijfte, Melissa Cambron, Brigitte Capron, Bernard Dachy, Danny Decoo, Dominique Dive, Bénédicte Dubois, Souraya El Sankari, Frederic London, Gaetano Perrotta, Veronica Popescu, Vincent van Pesch, Bart Van Wijmeersch, Barbara Willekens, Guy Laureys, Belgian Study Group for Multiple Sclerosis (BSGMS)
Access to, standardization and reimbursement of multidisciplinary care for people with MS (PwMS) is lacking in many countries. Therefore, this study aims to describe the current multidisciplinary care for people with MS (PwMS) in Belgium and identify benefits, needs and future perspectives A survey for PwMS questioned various aspects of MS and viewpoints on care. For MS nurses (MSN) and neurologists
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Do Proprioceptive Neuromuscular Facilitation Techniques Improve Respiratory Parameters and Swallowing in People with Multiple Sclerosis: A Randomized-Controlled Study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-11 Julide Kesebir, Rabia Gokcen Gozubatık Celik, Yonca Zenginler, Burcu Yüksel, Aysu Sen, Buket Akinci
This study aims to investigate the effects of Proprioceptive Neuromuscular Facilitation (PNF) techniques on respiratory parameters, swallowing, functional capacity, fatigue, and quality of life in people with Multiple Sclerosis (PwMS). Thirty-four PwMS were included and randomized into the PNF Group (mean age: 43.23±10.55/years) or Control Group (mean age:38.47±8.18/years). In the PNF group, head-neck
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Cerebrospinal fluid eosinophils in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-09 Alexandra B. Kornbluh, Victor M. Campano, Claire Har, Pallavi Dwivedi, William Suslovic, Leigh Sepeta, Ilana Kahn
Eosinophils in cerebrospinal fluid (CSF) are an uncommon finding most often associated with parasitic infections, but have also been described in some neuroinflammatory disorders. Eosinophilic infiltration is not thought to be a typical feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We aim to describe the rate of CSF eosinophil positivity in a cohort of pediatric
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Intrathecal B cell activation and memory impairment in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Lorenzo Gaetani, Nicola Salvadori, Giovanni Brachelente, Silvia Sperandei, Elena Di Sabatino, Andrea Fiacca, Andrea Mancini, Alfredo Villa, Nicola De Stefano, Lucilla Parnetti, Massimiliano Di Filippo
Cognitive impairment (CI) is a common and disabling feature of people with multiple sclerosis (pwMS), but its underlying mechanisms are heterogenous and not fully understood. A role of infiltrating immune cells in the meninges and brain parenchyma has been hypothesized. This study aimed to explore the hypothesis that intrathecal B cells might influence cognitive performance in pwMS. A retrospective
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Breakthrough COVID-19 in people with multiple sclerosis on disease modifying treatments: is it still a severe disease? Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Paolo Immovilli, Irene Schiavetti, Alessandro Franceschini, Paola De Mitri, Lorenza Gelati, Eugenia Rota, Donata Guidetti
Disease modifying treatments (DMTs) for multiple sclerosis (MS) are effective in preventing both relapses and disability progression. Highly effective treatments (HETs) are more effective than platform therapy in preventing confirmed disability progression (CDP), when used early. Infections may complicate HETs administration, and their prevention through vaccination is crucial in order to assure the
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Asthma and Chronic Obstructive Pulmonary Disease (COPD) in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 Hamed Ghoshouni, Nazanin Rafiei, Mohammad Yazdan Panah, Danial Dehghani Firouzabadi, Farhad Mahmoudi, Mona Asghariahmadabad, Vahid Shaygannejad, Omid Mirmosayyeb
Studies have found that multiple sclerosis (MS) has an impact on the initiation or the course of asthma and chronic obstructive pulmonary disease (COPD). The purpose of this study is to obtain a current estimate of the prevalence and odds of asthma and COPD in people with MS (pwMS) based on available literature. PubMed, Embase, Scopus, and Web of Science were systemically searched from inception to
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OCT-Angiography in AQP4-positive NMOSD: finding subclinical disease using a new tool Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 A, n, n, , Y, e, h
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Lymphocytic Infiltration in Multiple Sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-08 R, a, n, j, e, e, t, , S, i, n, g, h, , M, a, h, l, a
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Impact of rituximab treatment regime on time to relapse in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder. Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-07 Moneeb Nasir, Luke Hone, Emma Tallantyre, Patricia Kelly, Maria Isabel Leite, Neil Robertson, Jonathan Bestwick, Saif Huda, Jacqueline Palace, Ruth Dobson
Aquaporin-4 (AQP4) antibody associated neuromyelitis optica (NMOSD) requires long-term immunosuppression. Rituximab is increasingly used worldwide, however the optimal regime is not established. We retrospectively examined different rituximab regimens in AQP4-NMOSD. Standard monotherapy (SM; 6 monthly infusions), SM plus oral steroids (SM+S), extended interval dosing (EID; guided by CD19 repopulation)
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Exclusion of alternative diagnoses: A component of the 2023 MOGAD criteria that belongs at the forefront, not in the background Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-07 A, d, r, i, a, n, , B, u, d, h, r, a, m
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Metronomic radiological surveillance in clinically stable MS patients on anti CD20 immunotherapy is redundant Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-06 J, a, g, a, n, n, a, d, h, a, , A, v, a, s, a, r, a, l, a
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WHAT IS THE IMPORTANCE OF FAMILY PLANNING IN MULTIPLE SCLEROSIS? A STUDY IN THE BRAZILIAN POPULATION Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-05 Elisa Matias Vieira de Melo, Maria Fernanda Mendes, Guilherme Sciascia do Olival
Multiple Sclerosis is a disease of young females at a reproductive age. discuss family planning in the context of providing care for women with MS patients with Multiple Sclerosis, female, aged between 18-45 years, from 01/Nov/2021 to 16/Jan/2022 participated, all of whom answered a questionnaire made available on the Google forms platform. A total of 233 responses were validated. Most patients discuss
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Characteristics and predictors of sexual dysfunction in men with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-05 Ivan Adamec, Tomislav Sambolić, Mihovil Santini, Antea Karić, Anamari Junaković, Barbara Barun, Tereza Gabelić, Luka Crnošija, Magdalena Krbot Skorić, Mario Habek
To validate and culturally adapt the Sexual Health Inventory for Men (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT), to compare the frequency and severity of erectile dysfunction (ED) and premature ejaculation (PE) in male individuals with MS (mwMS) in comparison with healthy controls (HC) and to investigate predictors of the severity of ED and PE in mwMS. 216 consecutive mwMS and 37
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Prognostic factors of tumefactive demyelinating lesions and differential features for multiple sclerosis in etiology Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-05 Furkan Saridas, Gizem Mesut, Ceren Yayla Ceylan, Rifat Ozpar, Mine Ozsen, Emine Rabia Koc, Sahsine Tolunay, Bahattin Hakyemez, Omer Faruk Turan
Many different pathologies may underlie tumefactive demyelinating lesions. Identifying clinical and radiologic distinguishing features before pathologic examination is essential for diagnosis and treatment. In this study, we aimed to determine the clinical and radiologic features affecting the etiology and disease course of patients with tumefactive lesions (TDL). We included 35 clinicoradiologically
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Headache Disorders in Multiple Sclerosis: Is there an association? A systematic review and meta-analysis. Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-03 Panagiotis Gklinos, Dimos-Dimitrios Mitsikostas
To look for any potential association of headache disorders with multiple sclerosis (MS). The prevalence of headache disorders has been found to be increased in people with MS (pwMS), however, an association has not been established. Existing studies have provided conflicting results mostly because of methodological differences. PubMed, Embase and Scopus were searched to identify eligible studies.
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Seizures in inflammatory demyelinating disorders of the central nervous system Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-03 Özdem Ertürk Çetin, İpek Güngör Doğan, Ümit Zanapalioğlu, Feyzullah Yadi, Damla Çetinkaya Tezer, Serkan Demir
Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with acute symptomatic seizures and chronic epilepsy as well. The clinical features of the seizures and/or accompanying epilepsy seen in each disease group may vary. In this study, we aimed to contribute to the existing literature by
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Under & Over: A randomised controlled study to develop an upper limb rehabilitation tool for people with Multiple Sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-01 Alison Thomson, Andrea Stennett, Canan Metin, Jonathan Bestwick, Gavin Giovannoni, Ruth Dobson
Impairment of upper limb function is common in Multiple Sclerosis (MS). Rehabilitation remains a key strategy to manage symptoms and improve quality of life. The Under & Over study assessed the effectiveness of a rehabilitation programme in people with advanced MS. To determine if repeated use of Under & Over can improve upper limb function for people with MS. One hundred and six ( = 106) people with
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Comparison of patient-reported outcomes of physical activity and accelerometry in people with multiple sclerosis and ambulatory impairment: A cross-sectional study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-01 Andreas Wanitschek, Barbara Seebacher, Andreas Muehlbacher, Christian Brenneis, Rainer Ehling
Accelerometers and patient-reported outcomes (PRO) are used to assess physical activity (PA) in people with multiple sclerosis (pwMS). So far it is unknown, however, whether these assessments represent mobility limitations in pwMS with mild and moderate to severe disability alike. The primary aim of the study was to assess the correlation between accelerometry and International Physical Activity Questionnaire
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Role of C5 inhibitors in Neuromyelitis Optica Spectrum Disorders with Seropositive Anti-aquaporing-4 Antibody: A Systematic Review and Meta-Analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-03-01 Seraj Makkawi, Hassan K. Salamatullah, Ahmed Alkhiri, Dania E. Faidah, Lena M. Afif, Jawad I. Bukhari, Ahmad Abulaban, Yaser Al Malik, Michael Levy
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder characterized by relapses of inflammation and demyelination primarily affecting the optic nerve and the spinal cord. C5 complement inhibition is an effective therapeutic approach in the treatment of NMOSD. In this systematic review and meta-analysis, we aimed to determine the role of C5 inhibitors in the treatment of patients
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Serum lipids and cognitive outcomes in multiple sclerosis; a systematic review and meta-analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-29 Sarvin Sanaie, Narges Koohi, Reza Mosaddeghi-Heris, Shirin Rezai, Elahe Movagharnia, Hanie Karimi, Seyedehyasmin Moghaddamziabari, Sina Hamzehzadeh, Elnaz Gholipour-khalili, Mahnaz Talebi, Amirreza Naseri
Cognitive impairment is highly prevalent in multiple sclerosis (MS) with poorly understood underlying mechanisms. Lipids are considered to be associated with MS progression through the inflammatory and oxidative stress pathways, brain atrophy, cellular signaling, and tissue physiology. In addition, serum lipids are proposed as a modifiable factor affecting the neuropsychiatric conditions; therefore
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Cognitive function influences cognitive-motor interference during dual task walking in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-29 Wan-Yu Hsu, Valerie J Block, Jaeleene Wijangco, Kyra Henderson, Alyssa Nylander, Kanishka Koshal, Shane Poole, Katherine L. Possin, Adam M. Staffaroni, Riley M. Bove
Both physical and cognitive impairments are common in people with multiple sclerosis (PwMS). Performing a cognitive task while walking (i.e., dual-task walking) can introduce cognitive-motor interference (CMI), resulting in changes in walking performance. The association between the levels of cognitive impairment and of CMI in MS remains unclear. To examine the association between cognitive functioning
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Isolated myelin oligodendrocyte glycoprotein antibody-associated optic neuritis in adults: The importance of age of onset and prognosis-related radiological features Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-28 Juan Zhao, Xiaoli Chen, Jingxiao Zhang, Lei Liu, Jiawei Wang, Liping Zhu
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) exhibits phenotypic diversity and it varies by age. However, less is known about whether the manifestations of isolated MOG antibody-associated optic neuritis (iMOG-ON) vary across different age groups. We aimed to investigate the clinical and prognostic features of iMOG-ON in young and middle-aged adult patients. Patients
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The association of menopausal hormone levels with progression-related biomarkers in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-28 Laura Juutinen, Katja Ahinko, Sanna Hagman, Pabitra Basnyat, Olli Jääskeläinen, Sanna-Kaisa Herukka, Marja-Liisa Sumelahti
Multiple sclerosis (MS) progression coincides temporally with menopause. However, it remains unclear whether the changes in disease course are related to the changes in reproductive hormone concentrations. We assessed the association of menopausal hormonal levels with progression-related biomarkers of MS and evaluated the changes in serum neurofilament light chain (sNfL) and glial fibrillary acidic
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Epidemiology of aquaporin-4-IgG-positive NMOSD in Sardinia Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-28 Elia Sechi, Mariangela Puci, Maria Ida Pateri, Pietro Zara, Sabrine Othmani, Stefano Sotgiu, Maria Valeria Saddi, Stefania Leoni, Giuseppe Fenu, Maurizio Melis, Giovanni Sotgiu, Paolo Solla, Eleonora Cocco, Jessica Frau
The Italian Island of Sardinia (population, 1,578,146) is recognized for the high risk of multiple sclerosis (MS) but the epidemiological burden of other less common demyelinating diseases of the central nervous system (CNS), such as aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD), is unknown. In this study, we determined the incidence and prevalence of AQP4-IgG+NMOSD
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The risk of type 2 diabetes mellitus in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-27 Eun Bin Cho, Kyungdo Han, Jin-Hyung Jung, Yeon Hak Chung, Soonwook Kwon, Junhee Park, Sang-Man Jin, Dong Wook Shin, Ju-Hong Min
An association has been suggested between premorbid type 2 diabetes mellitus (T2DM) and the risk of multiple sclerosis (MS). However, little is known about the risk of developing T2DM in MS and neuromyelitis optica spectrum disorder (NMOSD). This study aimed to determine the T2DM risk in patients with MS and NMSOD. The Korean National Health Insurance Service database was analyzed, and 1,801 and 1
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Combination of serum markers with optical coherence tomography angiography for evaluating neuromyelitis optica spectrum disorders and multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-27 Chunxin Liu, WeiXiong Zhou, Xiaobo Sun, Xiayin Zhang, Hui Xiao, Hui Yang, Haotian Lin, Yaxin Lu, Zifeng Liu, Wei Qiu, Allan G. Kermode, Xiaoyan Yang, Yuge Wang
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS), autoimmune inflammatory diseases of the central nervous system, affect the optic nerve and brain. A lumbar puncture to obtain biomarkers is highly invasive. Serum biomarkers and optical coherence tomography angiography (OCTA) are more accessible and less expensive than magnetic resonance imaging and provide reliable, reproducible
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The discrimination between autoimmune glial fibrillary acidic protein astrocytopathy and tuberculous meningitis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-27 Yanxiang Chen, Chongliang Luo, Guonan Zhou, Hui Wang, Kai Dai, Weijuan Wu, Siguang Wang, Zhihui Su, Fuhua Peng, Ying Jiang
The differential diagnosis between autoimmune glial fibrillary acidic protein astrocytopathy (AGFAPA) mimicking tuberculous meningitis and tuberculous meningitis (TBM) remains challenging in clinical practice. This study aims to identify the clinical, laboratory parameters, and clinical score systems that may be helpful in differentiating AGFAPA from TBM. Overall 22 AGFAPA patients who were initially
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Feasibility study to assess lesion repair in relapsing-remitting multiple sclerosis: A randomized controlled pilot clinical trial of domperidone add-on treatment Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-27 Yunyan Zhang, Wei-Qiao Liu, Zahra Hosseinpour, G. Bruce Pike, Graziela Cerchiaro, Jamie Greenfield, V. Wee Yong, Luanne M. Metz
Identification of therapies to promote repair in multiple sclerosis is challenged by the lack of an accepted trial model and associated outcome measures. The goal of this study was to determine the feasibility of a new trial model that enrolls disease modifying therapy (DMT)-treated relapsing-remitting multiple sclerosis (RRMS) participants who have enhancing lesions on clinically indicated brain MRI
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Efficacy and comparison of corticosteroids only and corticosteroids with plasmapheresis or intravenous immunoglobulin for the treatment of optic neuritis in demyelinating disease: A systematic review and network meta-analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-27 Arnaud Gaulier, Jean-Benoit Hardouin, Sandrine Wiertlewski, Pierre Lebranchu
To compare the efficacy of treatment of optic neuritis (ON) with corticosteroids (CTC) alone, CTC+plasmapheresis (PLP), and CTC+intravenous immunoglobulin (IVIG). After an episode of ON, although visual recovery is usually good, some patients may have significant visual sequelae. While the efficacy of first-line CTC is now indisputable, there is no consensus on the nature of second-line treatment.
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Effectiveness of tixagevimab/cilgavimab (Evusheld) in antiCD20‑treated patients with multiple sclerosis and neuromyelitis optica spectrum disorder Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-27 D. Stastna, M. Vachova, P. Dusek, G. Fistravec, J. Drahota, I. Menkyova, E. Varju, D. Horakova, E. Kubala Havrdova, P. Nytrova
AntiCD20 therapy, such as rituximab, ocrelizumab, or ofatumumab, effectively treats patients with multiple sclerosis (pwMS) or neuromyelitis optica spectrum disorder (pwNMOSD) but negatively affects the humoral immune response to COVID-19 vaccination. One strategy to protect these patients is using tixagevimab/cilgavimab (T/C) as pre-exposure prophylaxis. This study aimed to evaluate the effect of
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Disparities in DMT treatment: Demographic and neurocognitive differences between MS patients currently treated versus not treated with disease-modifying therapies Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-22 Victoria M. Leavitt, Jordan D. Dworkin, Rachel Galioto, Alexander S. Ratzan
Current treatment guidelines recommend consideration of disease-modifying therapy (DMT) for all multiple sclerosis (MS) patients, but barriers to access have begun to be identified. In particular, prior studies have found that people with higher education have better access to DMTs, perhaps explained by the association of higher education with higher income. And while the majority of people with MS
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Effects of walking interventions in persons with multiple sclerosis—A systematic review Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-20 Ivana Boková, Tobias Gaemelke, Klara Novotná, Lars G. Hvid, Ulrik Dalgas
The aim of the present systematic review was to investigate the effects of voluntary walking interventions in persons with multiple sclerosis (pwMS). For this purpose, we developed a framework to describe the components of walking interventions. Two databases (MEDLINE/PubMed and EMBASE) were searched in January 2023. Included studies enrolled pwMS and evaluated walking interventions with a duration
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Unraveling the Complex Relationship: Multiple Sclerosis, Urinary Tract Infections, and Infertility Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-20 Maryam Seyedolmohadesin, Maedeh Ashkani, TaravaT Sadeghi Ghadikolaei, Maryam Mirshekar, Narjess Bostanghadiri, Soheila Aminzadeh
Multiple sclerosis (MS) is an immune system disorder that affects the central nervous system (CNS) and progressively damages nerve fibers and protective myelin. People with MS often experience a wide range of complications, including lower urinary tract dysfunction, urinary tract infections (UTIs) and sexual dysfunction. MS is common in young people and can lead to sexual dysfunction (SD) and infertility
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Adherence coaching is not shared-decision making! Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-19 C Heesen, S Köpke, AC Rahn
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Infrequent patterns in cerebrospinal fluid isofocusing test: Clinical significance and contribution of IgG index and Reiber diagram to their interpretation Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-18 Mouna Maaloul, Sabrina Mejdoub, Salma Sakka, Hend Hachicha, Mariem Dammak, Faten Koubaa, Chokri Mhiri, Hatem Masmoudi, Sawsan Feki
Cerebrospinal fluid (CSF) isoelectrofocusing (IEF) is considered as the gold standard for detecting an intrathecal synthesis of IgG, which is a hallmark of multiple sclerosis (MS). This corresponds to the presence of CSF-restricted IgG oligoclonal bands (OCB) (typically type 2 pattern). Moreover, this technique can also detect a systemic immune reaction with passive transfer of IgG (type 3 and 4 patterns)
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Healthcare utilization and costs associated with autologous haematopoietic stem cell transplantation in Norwegian patients with relapsing remitting multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-16 Katharina Natalie Gottschlich, Zinajda Zolic-Karlsson, Eline Aas, Silje Agnethe Stokke Kvistad, Lars Bø, Øivind Torkildsen, Anne Kristine Lehmann
Multiple sclerosis (MS) patients experience long-term deterioration of neurological function, reduced quality of life, long-lasting treatment cycles, and an increased risk of early workability loss imposing an economic burden to society. Autologous haematopoietic stem cell transplantation (AHSCT) has shown promising treatment effects for relapsing remitting MS (RRMS). This study employs a micro-costing
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Fear of Falling and Common Symptoms of Multiple Sclerosis: Physical Function, Cognition, Fatigue, Depression, and Sleep – A Systematic Review Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-16 Libak Abou, Joseph Peters, Bruno Freire, Jacob J. Sosnoff
Fear of falling (FOF) is a common concern among persons with multiple sclerosis (MS) and affects the performance of their daily living activities. Falls may result in FOF, leading to worsening of symptoms of MS, physical deconditioning, and exposure to future falls. This may trigger a vicious cycle between FOF and falls. A better understanding of the relationship between FOF and symptoms of MS may
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The effect of hip abductor strengthening exercises on lower limb strength asymmetry and balance in women with multiple sclerosis: A randomized controlled clinical trial Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-15 Sana RostamiAnhar, Sajad Roshani, Mehri Mohammadi Dangharalou, Narmin Ghani Zadeh Hesar
Patients with multiple sclerosis tend to use and move their body segments in an unbalanced way, which causes asymmetry of muscle strength, especially in the lower limbs. Among these muscles, the hip abductor muscles play a more important role in stabilizing the pelvis and maintaining balance. The purpose of this research was to investigate the effect of hip abductors exercises on lower limb strength
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Navigating the Discontinuation of Multiple Sclerosis First LineTreatments: A Paradigm Shift in Patient Care Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-15 Nazire Pinar Acar Ozen, Ece Gok Dursun, Asli Tuncer, Rana Karabudak
This retrospective study, conducted between 2005 and 2016, investigated the outcomes of patients with multiple sclerosis (MS) who discontinued injectable first-line disease-modifying therapies (DMTs). The study aimed to identify factors influencing treatment discontinuation and assess the impact of discontinuation on disease progression. Data was collected from 2,270 patients who received injectable
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Defining a standard set of health outcomes for patients with relapsing-remitting multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-13 Miguel Llaneza González, Pedro Carrascal Rueda, Olga Delgado Sánchez, Mónica Borges Guerra, Alfredo Rodríguez Antigüedad, Alberto Morell Baladrón, Noelia Becerril Ríos, Àlex Rovira, Virgina Meca Lallana, Laura Benedito-Palos, Marta Comellas, David Vilanova, Ainara Echeto, Xavier Pérez, Celia Oreja-Guevara
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White matter microstructural alterations in patients with anti-N-methyl-D-aspartate receptor encephalitis: A tract-based spatial statistics study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-12 Xiaoxuan wang, Yi Yin, Xinzhi Wang, Guang Xu, Junzhang Tian, Xiaofen Ma
Cognitive impairment is common in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis; however, neural mechanisms underlying this impairment remain unclear. Diffusion tensor imaging (DTI) is a potential method for studying the condition of white matter fibers in patients with anti-NMDAR encephalitis, allowing for an analysis of the neuroimaging mechanisms of cognitive impairment
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Real-world management of patients with neuromyelitis optica spectrum disorder using satralizumab: Results from a Japanese claims database Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-12 Ichiro Nakashima, Jin Nakahara, Hideo Yasunaga, Masami Yamashita, Nobuo Nishijima, Atsushi Satomura, Mariko Nio, Kazuo Fujihara
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Coping and psychological well-being among persons with relapsing-remitting multiple sclerosis: The role of perceived self-efficacy Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-12 Megan L. Bradson, Lauren B. Strober
To explore self-efficacy as a possible mediator in the relationship between adaptive coping and psychological well-being (PWB) in persons with relapsing-remitting multiple sclerosis (RRMS). 174 persons with RRMS (91% Female) completed an online survey consisting of psychosocial questionnaires. The COPE Inventory was used to create an adaptive coping composite that accounts for the relative contributions
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Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-11 Lindsey Wooliscroft, Amber Salter, Gautam Adusumilli, Victoria A. Levasseur, Peng Sun, Samantha Lancia, Dana C. Perantie, Kathryn Trinkaus, Robert T. Naismith, Sheng-Kwei Song, Anne H. Cross
Diffusion basis spectrum imaging (DBSI) extracts multiple anisotropic and isotropic diffusion tensors, providing greater histopathologic specificity than diffusion tensor imaging (DTI). Persistent black holes (PBH) represent areas of severe tissue damage in multiple sclerosis (MS), and a high PBH burden is associated with worse MS disability. This study evaluated the ability of DBSI and DTI to predict
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Clinical analysis of myelin oligodendrocyte glycoprotein antibody-associated disease in a diverse cohort of children: A single-center observational study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-11 Linda Nguyen, Cynthia X. Wang, Roberto S. Hernandez, Benjamin M. Greenberg
Prognostic markers for relapse and neurological disability following the first clinical event in children with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remain lacking. We investigated the clinical profiles and early prognostic factors associated with relapsing disease or impaired functional outcome in a large single-center cohort of pediatric MOGAD. We retrospectively
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Multi-registry analysis of patients with multiple sclerosis and neuromyelitis optica to improve capture of demographic data and compare visual outcomes Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-11 Heather E. Moss, Lauren Wiener, Caitlin Rizy, Shrujal Baxi, Manan Kocher, Aracelis Z. Torres, Michael Mbagwu
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Senescence marker p16INK4a expression in patients with multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-11 Jennifer H. Yang, Annalise E. Miner, Ashley Fair, Revere Kinkel, Jennifer S. Graves
Telomere attrition is associated with disability accumulation and brain atrophy in multiple sclerosis (MS). Downstream of telomere attrition is cellular senescence. We sought to determine differences in the cellular senescence marker p16INK4a expression between MS and healthy control participants and the association of p16INK4a expression with MS disability and treatment exposure. Patients meeting
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Cervical lymph node diameter reflects disease progression in multiple sclerosis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-11 Anni Tuulasvaara, Goran Kurdo, Juha Martola, Sini M. Laakso
Multiple sclerosis (MS) is an autoimmune disease against the central nervous system (CNS), where B cells activate in the deep cervical lymph nodes (CLNs) before migrating to the CNS. CLN diameter in head magnetic resonance imaging (MRI) is an unexplored possible biomarker for disease activity. We measured CLN axial diameter from head MRIs of patients with active stable relapsing-remitting MS (a-RRMS-stable
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Similar geographic distribution of mortality from multiple sclerosis, Hodgkin lymphoma, and inflammatory bowel disease in the United States Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-10 Amnon Sonnenberg
Previous epidemiologic studies have suggested a linkage between the occurrence of multiple sclerosis (MS), Hodgkin lymphoma (HL), Crohn's disease (CD), and ulcerative colitis (UC). It was hypothesized that the 4 diagnoses would be characterized by similar geographic distributions within the United States. To compare the US geographic distributions of these 4 diagnoses in a cross-sectional study. Using
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Aberrant white matter microstructure detected by automatic fiber quantification in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-09 Shuang Ding, Zhuowei Shi, Kaiping Huang, Xiao Fan, Xiujuan Li, Helin Zheng, Longlun Wang, Zichun Yan, Jinhua Cai
Myelin oligodendrocyte glycoprotein antibody-associated diseases (MOGAD) is an idiopathic inflammatory demyelinating disorder in children, for which the precise damage patterns of the white matter (WM) fibers remain unclear. Herein, we utilized diffusion tensor imaging (DTI)-based automated fiber quantification (AFQ) to identify patterns of fiber damage and to investigate the clinical significance
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Cerebrospinal fluid mtDNA concentrations are increased in multiple sclerosis and were normalized after intervention with autologous hematopoietic stem cell transplantation Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-03 Ivan Pavlovic, Christina Zjukovskaja, Faisal Hayat Nazir, Malin Müller, Anna Wiberg, Joachim Burman
Mitochondrial DNA (mtDNA) is a pro-inflammatory damage-associated molecular pattern molecule and could be an early indicator for inflammation and disease activity in MS. Autologous hematopoietic stem cell transplantation (aHSCT) is a potent treatment for MS, but its impact on mtDNA levels in cerebrospinal fluid (CSF) remains unexplored. To verify elevated CSF mtDNA concentrations in MS patients and
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Virtual reality rehabilitation in patients affected by multiple sclerosis: Impact on quality of life and sexual functions Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-03 Maria Grazia Maggio, Amelia Rizzo, Angelo Quartarone, Alfredo Manuli, Rocco Salvatore Calabrò
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The effect of exercise on mental health and health-related quality of life in individuals with multiple sclerosis: A Systematic review and meta-analysis Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-01 Luca Beratto, Lara Bressy, Samuel Agostino, Francesca Malandrone, Giampaolo Brichetto, Matteo Ponzano
A large body of evidence has tested the effect of exercise interventions on mental health and health-related quality of life (HRQoL) in individuals with multiple sclerosis (PwMS). To determine the effect of exercise interventions on mental health and HRQoL in PwMS. We searched four databases up to April 2023, and included randomized controlled trials that: 1) involved PwMS ≥18 years old; 2) delivered
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Clinical and demographic characteristics of late-onset multiple sclerosis: LOMS-TR study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-01 Ali Özhan Sıvacı, Meral Seferoğlu, Bilge Piri Çınar, Cihat Uzunköprü, Yeşim Beckmann, İpek Güngör Doğan, Damla Çetinkaya Tezer, Abdulkadir Tunç, Özlem Ethemoğlu, Haluk Gümüş, Mustafa Açıkgöz, Ülgen Yalaz Tekan, Serkan Demir
: Multiple sclerosis (MS), which is known as a young-adult age disease, is called late-onset MS (LOMS) when it occurs at the age of 50 and older. In our study, we aimed to analyse the clinical and demographic characteristics, comorbidities, diagnostic and treatment challenges and prognosis of LOMS. : In a retrospective analysis of 136 patients diagnosed with multiple sclerosis (MS) after the age of
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Prevalence and incidence of multiple sclerosis in Isfahan, Iran between 1996 and 2021: A population-based study Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-02-01 Mahdi Barzegar, Saeed Vaheb, Omid Mirmosayyeb, Fereshteh Ashtari, Alireza Afshari-Safavi, Iman Adibi, Aysa Shaygannejad, Shahrbanoo Mazaheri, Maryam Rahimi, Vahid shaygannejad
There has been no recent comprehensive epidemiological study on a large and stable population of multiple sclerosis (MS) in Isfahan. Therefore, we conducted this study to estimate the incidence and prevalence of MS in Isfahan province from 1996 to 2021. In this population-based study, we utilized the dataset from the Vice-Chancellor's Office of Isfahan University of Medical Sciences, which registers
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Concurrent Glioma and Multiple Sclerosis: A Systematic Review of Case Reports Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-01-28 Amirhossein Nafari, Elham Moases Ghaffary, Vahid Shaygannejad, Omid Mirmosayyeb
Background : It is uncommon for individuals with demyelinating disease, notably multiple sclerosis (MS), to be diagnosed with intracranial gliomas. It has been debated whether or not the concurrence of these two disorders is accidental. Clinically, it may be challenging to diagnose someone who has MS and an intracranial tumor simultaneously. We conducted this systematic review to evaluate the glioma
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THE ROLE OF OLIGOCLONAL BAND COUNT AND IGG INDEX IN TREATMENT RESPONSE AND DISEASE ACTIVITY IN MULTIPLE SCLEROSIS Mult. Scler. Relat. Disord. (IF 4.0) Pub Date : 2024-01-27 Esra Taşkıran, Murat Terzi, Elif Merve Helvacı, Meltem Zeycan Eser, Bahattin Avcı, Turan Ömer Faruk, Mehmet Fatih Yetkin, Vedat Çilingir, Levent Sinan Bir, Sibel Canbaz Kabay, Nuray Bilge, Turan Poyraz, Caner Feyzi Demir, Dilcan Kotan Dündar, Özgül Ocak, Mustafa Çam, Hatice Mavioğlu, Yaşar Altun, Adnan Karaibrahimoğlu
Background/Aim Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal