样式: 排序: IF: - GO 导出 标记为已读
-
The impact of prenatal alcohol, synthetic cannabinoid and co-exposure on behavioral adaptations in adolescent offspring and alcohol self-administration in adulthood Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-03-14 Laura C. Ornelas, Eric W. Fish, Jacob C. Dooley, Megan Carroll, Scott E. Parnell, Joyce Besheer
Prenatal exposure to alcohol or cannabinoids can produce enduring neurobiological, cognitive, and behavioral changes in the offspring. Furthermore, prenatal co-exposure to alcohol and cannabinoids induces malformations in brain regions associated with reward and stress-related circuitry. This study examined the effects of co-exposure to alcohol and the synthetic cannabinoid (SCB) CP55,940 throughout
-
The association between prenatal cannabis use and congenital birth defects in offspring: A cumulative meta-analysis Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-03-07 Abay Woday Tadesse, Getinet Ayano, Berihun Assefa Dachew, Biruk Shalmeno Tusa, Yitayish Damtie, Kim Betts, Rosa Alati
To examine the association between prenatal cannabis use and structural birth defects in exposed offspring. In line with the preregistered protocol (PROSPERO: CRD42022368623), we systematically searched PubMed/Medline, CINHAL, EMBASE, Web of Science, ProQuest, Psych-Info, and Google Scholar for published articles until 25 January 2024. The methodological quality of the included studies was appraised
-
Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-03-06 Alexandra Stickler, Andrew B. Hawkey, Anas Gondal, Sarabesh Natarajan, Mikayla Mead, Edward D. Levin
Developmental exposure to either polycyclic aromatic hydrocarbons (PAHs) or heavy metals has been shown to cause persisting and overlapping neurobehavioral effects in animal models. However, interactions between these compounds have not been well characterized, despite their co-occurrence in a variety of environmental media. In two companion studies, we examined the effects of developmental exposure
-
Combined and sequential exposure to prenatal second hand smoke and postnatal maternal distress is associated with cingulo-opercular global efficiency and attention problems in school-age children Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-03-01 Paige B. Greenwood, Mariah DeSerisy, Emily Koe, Elizabeth Rodriguez, Leilani Salas, Frederica P. Perera, Julie Herbstman, David Pagliaccio, Amy E. Margolis
Prenatal exposure to secondhand (environmental) tobacco smoke (SHS) is associated with adverse neurodevelopmental outcomes, including altered functional activation of cognitive control brain circuitry and increased attention problems in children. Exposure to SHS is more common among Black youth who are also disproportionately exposed to socioeconomic disadvantage and concomitant maternal distress.
-
Maternal choline supplementation lessens the behavioral dysfunction produced by developmental manganese exposure in a rodent model of ADHD Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-02-27 Shanna L. Howard, Stephane A. Beaudin, Barbara J. Strupp, Donald R. Smith
Studies in children have reported associations between elevated manganese (Mn) exposure and ADHD-related symptoms of inattention, impulsivity/hyperactivity, and psychomotor impairment. Maternal choline supplementation (MCS) during pregnancy/lactation may hold promise as a protective strategy because it has been shown to lessen cognitive dysfunction caused by numerous early insults. Our objectives were
-
A novel deep learning-based method for automatic stereology of microglia cells from low magnification images Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-02-23 Hunter Morera, Palak Dave, Yaroslav Kolinko, Saeed Alahmari, Aidan Anderson, Grant Denham, Chloe Davis, Juan Riano, Dmitry Goldgof, Lawrence O. Hall, G. Jean Harry, Peter R. Mouton
Microglial cells mediate diverse homeostatic, inflammatory, and immune processes during normal development and in response to cytotoxic challenges. During these functional activities, microglial cells undergo distinct numerical and morphological changes in different tissue volumes in both rodent and human brains. However, it remains unclear how these cytostructural changes in microglia correlate with
-
Pathways from prenatal cocaine exposure to adult substance use and behavior Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-02-17 Gale A. Richardson, Natacha M. De Genna, Jennifer A. Willford, Lidush Goldschmidt
This is a report from the most recent adult follow-up of the longest running cohort study of prenatal cocaine exposure (PCE), in which women were enrolled prenatally and offspring were assessed in infancy, childhood, adolescence, and young adulthood. In previous studies, PCE was linked to offspring behavior problems such as early substance use and externalizing behavior problems. The current analyses
-
Impact of in utero tobacco exposure on fetal growth: Amount of exposure and second trimester fetal growth measurements Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-02-13 Beth A. Bailey, Haley Kopkau, Katherine Nadolski, Phoebe Dodge
Research reveals small and inconsistent findings linking prenatal tobacco exposure and early fetal growth, but failure to consider confounding and amount of exposure many explain inconsistencies. To examine whether fetal growth effects following exposure to tobacco are evident in the second trimester, specific to certain growth parameters, and dose dependent. Participants were pregnant women (64 smokers
-
Bisphenol F affects neurodevelopmental gene expression, mushroom body development and behavior in Drosophila melanogaster Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-30 Judith L.A. Fishburn, Heather L. Larson, An Nguyen, Chloe J. Welch, Taylor Moore, Aliyah Penn, Johnathan Newman, Anthony Mangino, Erin Widman, Rana Ghobashy, Jocelyn Witherspoon, Wendy Lee, Kimberly A. Mulligan
Bisphenol F (BPF) is a potential neurotoxicant used as a replacement for bisphenol A (BPA) in polycarbonate plastics and epoxy resins. We investigated the neurodevelopmental impacts of BPF exposure using Drosophila melanogaster as a model. Our transcriptomic analysis indicated that developmental exposure to BPF caused the downregulation of neurodevelopmentally relevant genes, including those associated
-
-
Sensorimotor dysfunction due to developmental manganese exposure is less severe in adult female than male rats and partially improved by acute methylphenidate treatment Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-02-01 Stephane A. Beaudin, Samantha Gorman, Naomi Schilpp, David Woodfin, Barbara J. Strupp, Donald R. Smith
Epidemiological studies have reported associations between elevated manganese (Mn) exposure and poorer psychomotor performance in children. Our studies in adult male rats have established that this relationship is causal and that prolonged MPH treatment is efficacious in treating this area of dysfunction. However, it is unclear if sensitivity to these Mn deficits differs between females and males,
-
DDT and titanium dioxide nanoparticle coexposure induced neurobehavioral deficits in zebrafish Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-24 Jian Lin, Yanqi Lou, Zhenkai Sun, Dongliang Pan, Lei Lei, Yang Song, Changjiang Huang, Jiangfei Chen
Both dichlorodiphenyltrichloroethane (DDT) and titanium dioxide nanoparticle (TiO2 NP) have worldwide-scale commercial applications, resulting in their co-pollution in the ecosystems and posing combined health risks. However, there is a lack of toxicity studies for the interactions of DDT and TiO2 NP in the environmental relevant concentrations. In this study, we characterized the coexposures using
-
Maternal prenatal lead levels and neonatal brain volumes: Testing moderations by maternal depressive symptoms and family income Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-18 Amanda C. Wylie, Sarah J. Short, Rebecca C. Fry, W. Roger Mills-Koonce, Cathi B. Propper
There is considerable evidence that prenatal lead exposure is detrimental to child cognitive and socio-emotional development. Further evidence suggests that the effects of prenatal lead on developmental outcomes may be conditional upon exposure to social stressors, such as maternal depression and low socioeconomic status. However, no studies have examined associations between these co-occurring stressors
-
The U.S. PFAS exposure burden calculator for 2017–2018: Application to the HOME Study, with comparison of epidemiological findings from NHANES Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-13 Shelley H. Liu, Yitong Chen, Leah Feuerstahler, Aimin Chen, Anne Starling, Dana Dabelea, Xiaobin Wang, Kim Cecil, Bruce Lanphear, Kimberly Yolton, Joseph M. Braun, Jessie P. Buckley
Background The 2017–2018 U.S. PFAS exposure burden calculator was designed to provide a summary exposure score for per- and polyfluoroalkyl substances (PFAS) mixtures using targeted PFAS analyte data. Its aim was to place PFAS burden score estimates onto a common scale based on nationally representative U.S. reference ranges from 2017 to 2018, enabling comparisons of overall PFAS burden scores across
-
Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-08 Cameron J. Davidson, John H. Hannigan, Shane A. Perrine, Scott E. Bowen
Currently, there is a gap in understanding the neurobiological impact early adolescent toluene exposure has on subsequent actions of other drugs. Adolescent (PND 28–32) male Swiss-Webster mice (N = 210) were exposed to 0, 2000, or 4000 ppm (ppm) of toluene vapor for 30 min/day for 5 days. Immediately following the last toluene exposure (PND 32; n = 15) or after a short delay (PND 35; n = 15), a subset
-
The relationship of prenatal acetaminophen exposure and attention-related behavior in early childhood Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-08 Megan L. Woodbury, Sarah D. Geiger, Susan L. Schantz
Acetaminophen is currently the only analgesic considered safe for use throughout pregnancy, but recent studies indicate that prenatal exposure to acetaminophen may be related to poorer neurodevelopmental outcomes. Multiple studies have suggested that it may be associated with attention problems, but few have examined this association by trimester of exposure. The Illinois Kids Development Study is
-
Developmental exposure to methylmercury alters GAD67 immunoreactivity and morphology of endothelial cells and capillaries of midbrain and hindbrain regions of adult rat offspring Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-08 Nazneen Y. Rustom
Introduction Methylmercury (MeHg) is an environmental contaminant that is of particular concern in Northern Arctic Canadian populations. Specifically, organic mercury compounds such as MeHg are potent toxicants that affect multiple bodily systems including the nervous system. Developmental exposure to MeHg is a major concern, as the developing fetus and neonate are thought to be especially vulnerable
-
Exposure to the pharmaceutical buspirone alters locomotor activity, anxiety-related behaviors, and transcripts related to serotonin signaling in larval zebrafish (Danio rerio) Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2024-01-02 Angel Biju, Emma Ivantsova, Christopher L. Souders, Cole English, Lev Avidan, Christopher J. Martyniuk
Buspirone is a pharmaceutical used to treat general anxiety disorder by acting on the dopaminergic and serotoninergic system. Buspirone, like many human pharmaceuticals, has been detected in municipal wastewater; however, the environmental exposure risks are unknown for this psychoactive compound. We studied the effects of buspirone on the behavior of zebrafish, focusing on locomotor and anxiolytic
-
-
Amniotic fluid cortisol predicts neonatal and infant development in non-stressed rhesus monkeys: Implications for prenatal stress Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-10-27 Jeremy Otridge, Jerrold S. Meyer, Amanda M. Dettmer
Prenatal stress adversely affects offspring development, with fetal cortisol (CORT) exposure being a primary hypothesized mechanism for stress-induced developmental deficits. Fetal CORT exposure can be assessed via measurements in amniotic fluid. However, in humans, amniocentesis is typically only performed for clinical reasons such as karyotyping; thus, amniotic fluid CORT cannot be obtained from
-
Early-life manganese exposure during multiple developmental periods and adolescent verbal learning and memory Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-10-11 Alexa Friedman, Samantha Schildroth, Julia A. Bauer, Brent A. Coull, Donald R. Smith, Donatella Placidi, Giuseppa Cagna, Maxine H. Krengel, Yorghos Tripodis, Roberta F. White, Roberto G. Lucchini, Robert O. Wright, Megan Horton, Christine Austin, Manish Arora, Birgit Claus Henn
Background Manganese (Mn) is both an essential and toxic metal, and associations with neurodevelopment depend on exposure timing. Prospective data examining early life Mn with adolescent cognition are sparse. Methods We enrolled 140 Italian adolescents (10–14 years old) from the Public Health Impact of Metals Exposure study. Mn in deciduous teeth was measured using laser ablation-mass spectrometry
-
Teratogenic impacts of Antiepileptic drugs on development, behavior and reproduction in Drosophila melanogaster Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-10-05 Shamapari R., Nagaraj K.
-
PFOS-induced dyslipidemia and impaired cholinergic neurotransmission in developing zebrafish: Insight into its mechanisms Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-10-05 Archisman Mahapatra, Priya Gupta, Anjali Suman, Shubhendu Shekhar Ray, Rahul Kumar Singh
-
Juvenile variable stress modulates, in female but not in male Wistar rats, ethanol intake in adulthood Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-10-04 Agustín Salguero, Agostina Barey, Rodrigo García Virgolini, Victoria Mujica, María Carolina Fabio, Roberto Sebastián Miranda-Morales, Leonardo Marengo, Rosana Camarini, Ricardo Marcos Pautassi
Early stress can increase vulnerability to psychopathological disorders, including substance use disorders. The effects of stress in the juvenile period of the rat, that extends between weaning and the onset of adolescence (equivalent to late human childhood), have received little attention. This study assessed short and long-term behavioral effects of juvenile stress, with a focus on effects on ethanol
-
Differential gene expression profiling implicates altered network development in rat postnatal day 4 cortex following 4-Methylimidazole (4-MeI) induced maternal seizures Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-10-01 Abdull J. Massri, Mackenzie Fitzpatrick, Helen Cunny, Jian-Liang Li, G. Jean Harry
Compromised maternal health leading to maternal seizures can have adverse effects on the healthy development of offspring. This may be the result of inflammation, hypoxia-ischemia, and altered GABA signaling. The current study examined cortical tissue from F2b (2nd litter of the 2nd generation) postnatal day 4 (PND4) offspring of female Harlan SD rats chronically exposed to the seizuregenic compound
-
An optimized radioimmunoassay for quantification of total serum thyroxine (T4) in fetal, neonatal, and pregnant rats Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-28 Katherine L. O'Shaughnessy, Michelle G. Hotchkiss, Angela K. Buckalew, Ashley S. Murr, Mary E. Gilbert, Tammy E. Stoker
-
Unveiling the molecular mechanisms and developmental consequences of mercury (Hg) toxicity in zebrafish embryo-larvae: A comprehensive approach Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-21 Magda Carvalho Henriques, Inês Carvalho, Cátia Santos, Maria Teresa Herdeiro, Margarida Fardilha, Maria Dimitriou Pavlaki, Susana Loureiro
Mercury (Hg) is a global contaminant affecting aquatic ecosystems' health. Chronic exposure to Hg has shown that the normal development of zebrafish embryo-larvae is affected. However, the molecular mechanisms behind the toxicity of Hg on fish embryonic development are still poorly understood. This work aimed to investigate the effects of Hg exposure on zebrafish embryo-larvae using a combined approach
-
Neurodevelopmental outcomes in children and adults with Fetal Valproate Spectrum Disorder: A contribution from the ConcePTION project Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-04 M. Bluett-Duncan, D. Astill, R. Charbak, J. Clayton-Smith, S. Cole, P.A. Cook, J. Cozens, K. Keely, J. Morris, R. Mukherjee, E. Murphy, P. Turnpenny, J. Williams, A.G. Wood, L.M. Yates, R.L. Bromley
-
Association between fluoride exposure in drinking water and cognitive deficits in children: A pilot study Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-09 Tewodros Rango Godebo, Marc Jeuland, Redda Tekle-Haimanot, Biniyam Alemayehu, Arti Shankar, Amy Wolfe, Nati Phan
Fluoride (F) exposure in drinking water may lead to reduced cognitive function among children; however, findings largely remain inconclusive. In this pilot study, we examined associations between a range of chronic F exposures (low to high: 0.4 to 15.5 mg/L) in drinking water and cognition in school-aged children (5–14 years, n = 74) in rural Ethiopia. Fluoride exposure was determined from samples
-
Impact of early-life lead exposure on adult delta-9-tetrahydrocannabinol sensitivity in male and female C57BL6/J mice Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-09 Daniel Garcy, Stephen L. Boehm
Environmental exposure to lead (Pb) and cannabis use are two of the largest public health issues facing modern society in the United States and around the world. Exposure to Pb in early life has been unequivocally shown to have negative impacts on development, and recent research is mounting showing that it may also predispose individuals for risk of developing substance use disorders (SUD). At the
-
Toxic effects of exogenous retinoic acid on the neurodevelopment of zebrafish (Danio rerio) embryos Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-07 Xiaoxuan Wang, Ting Ma, Cizhao Wei, Juan Liu, Ting Yu, Yu Zou, Song Liu, Zheqiong Yang, Jinlei Xi
Endogenous retinoic acid (RA) is essential for embryonic development and maintaining adult physiological processes. Human-caused RA residues in the environment threaten the survival of organisms in the environment. We employed zebrafish as a model to explore the developmental impacts of excess RA. We used exogenous RA to raise the amount of RA signal in the embryos and looked at the effects of excess
-
Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-09-07 Serguei Liachenko, Jaivijay Ramu, Merle G. Paule, Joseph Hanig
The assessment of the sensitivity and specificity of any potential biomarker against the gold standard is an important step in the process of its qualification by regulatory authorities. Such qualification is an important step towards incorporating the biomarker into the panel of tools available for drug development. In the current study we analyzed the sensitivity and specificity of T2 MRI relaxometry
-
Region- and age-specific effects of perinatal phthalate exposure on developmental cell death and adult anatomy of dorsal and ventral hippocampus and associated cognitive behaviors Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-08-16 Elli P. Sellinger, Amara S. Brinks, Rajvi R. Javeri, Savannah L. Theurer, Ruibin Wang, Janice M. Juraska
Humans are exposed to phthalates, a class of endocrine-disrupting chemicals used in food packaging/processing, PVC plastics, and personal care products. Gestational exposure may lead to adverse neurodevelopmental outcomes. In a rat model, perinatal exposure to an environmentally relevant mixture and dose of phthalates leads to increased developmental apoptosis in the medial prefrontal cortex (mPFC)
-
Change in marijuana use from adolescence to young adulthood and its relation to gestational alcohol and marijuana exposure Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-07-10 Lidush Goldschmidt, Gale A. Richardson, Nancy L. Day, Natacha M. De Genna
Introduction Many studies have examined changes in marijuana use across adolescence, but few have examined factors associated with transitions from adolescence to young adulthood. We examined prenatal exposures to alcohol and marijuana and adolescent risk and protective factors that best distinguished among abstinence, continuity, or cessation of marijuana use from 16 to 22 years. Method Data were
-
Spatiotemporal protein dynamics during early organogenesis in mouse conceptuses treated with valproic acid Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-07-11
Valproic acid (VPA) is an anti-epileptic medication that increases the risk of neural tube defect (NTD) outcomes in infants exposed during gestation. Previous studies into VPA's mechanism of action have focused on alterations in gene expression and metabolism but have failed to consider how exposure changes the abundance of critical developmental proteins over time. This study evaluates the effects
-
Gestational paracetamol exposure induces core behaviors of neurodevelopmental disorders in infant rats and modifies response to a cannabinoid agonist in females Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-06-29 Rodrigo Moreno Klein, Vanessa Nishikawa Motomura, Juliana Diosti Debiasi, Estefânia Gastaldello Moreira
Paracetamol (PAR) is an over-the-counter analgesic/antipyretic used during pregnancy worldwide. Epidemiological studies have been associating gestational PAR exposure with neurobehavioral alterations in the progeny resembling autism spectrum disorders and attention-deficit hyperactivity disorder symptoms. The endocannabinoid (eCB) dysfunction was previously hypothesized as one of the modes of action
-
Differential effects of dopamine receptor agonists ropinirole and quinpirole on locomotor and anxiolytic behaviors in larval zebrafish (Danio rerio): A role for the GABAergic and glutamate system? Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-05-19 Andrew Wengrovitz, Emma Ivantsova, Natalie Crespo, Mansi Patel, Christopher L. Souders, Christopher J. Martyniuk
Zebrafish are frequently used as a vertebrate model to elucidate toxicological and pharmacological mechanisms of action in the central nervous system. Pharmacological studies demonstrate that dopamine, signaling via several receptor subtypes, regulates zebrafish larval behavior. Quinpirole is a selective dopamine receptor agonist for D2 and D3 subtypes while ropinirole exhibits selectivity toward D2
-
Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-05-11 Carly V. Goodman, Christine Till, Rivka Green, Jana El-Sabbagh, Tye E. Arbuckle, Richard Hornung, Bruce Lanphear, Jean R. Seguin, Linda Booij, Mandy Fisher, Gina Muckle, Maryse F. Bouchard, Jillian Ashley-Martin
Background Exposure to perfluoroalkyl substances (PFAS) has been shown to be neurotoxic in experimental studies, but epidemiological evidence linking prenatal PFAS exposure to child neurodevelopment is equivocal and scarce. Objective To quantify associations between prenatal exposure to legacy PFAS and children's intelligence (IQ) and executive functioning (EF) in a Canadian pregnancy and birth cohort
-
Di-butyl phthalate disrupts muscle, motor and sensory neuron development in embryonic zebrafish Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-05-05 Evelyn Paquette, Alissa Rodrigues, Michael Fumo, John Paul Giacalone, Nicole M. Roy
Phthalates are added to plastics to enhance its flexibility, durability and transparency. Phthalates are not covalently bound to plastics and leach into the environment. Phthalates are now pervasive and ubiquitously present in the atmosphere, soil and sediment, surface and wastewater. Phthalates are known endocrine disruptors and their effects on male and female reproduction are well noted. However
-
Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with measures of cognition in 7.5-month-old infants: An exploratory study Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-05-10 Elizabeth A. Enright, Stephanie M. Eick, Rachel Morello-Frosch, Andréa Aguiar, Megan L. Woodbury, Jenna L.N. Sprowles, Sarah Dee Geiger, Jessica Trowbridge, Aileen Andrade, Sabrina Smith, June-Soo Park, Erin DeMicco, Amy M. Padula, Tracey J. Woodruff, Susan L. Schantz
Background Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to a wide array of adverse maternal and child health outcomes. However, studies examining PFAS in relation to offspring cognition have been inconclusive. Objective We examined whether prenatal exposure to a mixture of PFAS was related to cognition in 7.5-month-old infants. Methods Our analytic sample included
-
Vitamin D supplementation positively affects activity but impairs stimulus response behavior in an age and sex specific manner in C57BL/6 mice Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-05-07 David A. Narvaiz, Eliesse M. Kwok, Samantha L. Hodges, Matthew S. Binder, Suzanne O. Nolan, Zachary J. Pranske, Savannah Senger, Rebecca Herrera, Joaquin N. Lugo
-
Antibiotic treatment during post-natal reverses behavioural and molecular alterations in experimental meningitis survivor rat model Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-05-03 Arumugam Kamaladevi, Koilmani Emmanuvel Rajan
The present study was aimed to examine the behavioural and molecular alterations in experimental meningitis survivor rat model. On postnatal day (PND)-2, animals were assigned to different groups: (i) Control (Ctrl), (ii) Positive Control [PCtrl: gavaged with Luria-Bertani (LB) broth on PND-2 and received antibiotics treatment (AbT) from PND-5 to 11], (iii) Cronobacter sakazakii (CS: received single
-
Effects of medications for opioid use disorder (MOUD) on fetal brain and cranial measurements Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-04-19 Conrad R. Chao, Jose Perez Yordan, Melissa Roberts, Xingya Ma, Bradley Holbrook, William Rayburn, Ludmila N. Bakhireva
Background The use and misuse of opioids, as well as opioid use disorder (OUD) have increased remarkably among reproductive-aged and pregnant women. As many as 25% of pregnant women who report non-medical opioid use in the past month also report concurrent alcohol use. While teratogenic effects of alcohol are well established, there are limited studies evaluating fetal intracranial effects associated
-
A 12-month follow-up of infant neurodevelopmental outcomes of prenatal opioid exposure and polysubstance use Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-04-11 Lydia Bierce, Alexandra R. Tabachnick, Rina D. Eiden, Mary Dozier, Madelyn H. Labella
Background Prenatal opioid exposure has been associated with developmental deficits during infancy, but the literature is limited by simple group comparisons and lack of appropriate controls. Previously published research with the current sample documented unique associations between prenatal opioid exposure and developmental outcomes at three and six months, but less is known about associations later
-
Perinatal nicotine exposure relates to stimulus-locked event-related potentials in early adolescence during an emotional go/no-go task Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-04-05 Christine L. Lackner, Bailey Thompson, Diane L. Santesso, Terrance J. Wade, Sidney J. Segalowitz
Nicotine exposure is associated with negative consequences on the developing brain, both in utero and after birth. We investigated the relationship between perinatal nicotine exposure and electroencephalographic brain activity recorded during an emotional faces Go/No-Go task among adolescents. Seventy-one adolescents aged 12–15 years completed a Go/No-Go task using fearful and happy faces. Parents
-
Sources, occurrence and toxic effects of emerging per- and polyfluoroalkyl substances (PFAS) Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-03-11 Y. Manojkumar, Sridhar Pilli, P. Venkateswara Rao, Rajeshwar Dayal Tyagi
Per- and polyfluoroalkyl substances (PFAS) cause potential threats to biota and are persistent and never-ending substances in the environment. Regulations and ban on legacy PFAS by various global organizations and national level regulatory agencies had shifted the fluorochemical production to emerging PFAS and fluorinated alternatives. Emerging PFAS are mobile and more persistent in aquatic systems
-
Discontinuation of methylphenidate after long-term exposure in nonhuman primates Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-03-08 X. Zhang, M.S. Berridge, S.M. Apana, W. Slikker, M.G. Paule, John Talpos
Attention-deficit hyperactivity disorder (ADHD) is a common human neurobehavioral disorder that usually begins in early childhood. Methylphenidate (MPH) has been used extensively as a first-line medicine for the treatment of ADHD. Since ADHD is often diagnosed in early childhood and can persist for the entire lifespan, individuals may take MPH for many years. Given that in the course of one's lifetime
-
Embryonic exposure to PFAS causes long-term, compound-specific behavioral alterations in zebrafish Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-02-18 Andrew B. Hawkey, Mikayla Mead, Sarabesh Natarajan, Anas Gondal, Olivia Jarrett, Edward D. Levin
Per- and polyfluoroalkyl substances (PFAS) are commonly used as surfactants and coatings for industrial processes and consumer products. These compounds have been increasingly detected in drinking water and human tissue, and concern over their potential effects on health and development is growing. However, relatively little data are available for their potential impacts on neurodevelopment and the
-
Cold stress during the perinatal period leads to developmental and neurobehavioral toxicity in zebrafish larvae Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-02-16 Shu-Yun Zhang, Yuhang Lei, Qiuju Liang, Yigan Wang, Yi Zheng, Xiufeng Gan, Chenglian Bai, Jiangfei Chen
In nature, cold stress is a core threat to aquatic organisms. But the neurodevelopmental effects of cold stress during the perinatal period on the offspring development were unknown. In the present study, adult zebrafish were cold-stressed at 18 °C for five days before spawning, and then the fertilized eggs were raised at 18, 24, or 28 °C from 0 to 120 h post fertilization (hpf). The resulting embryos
-
Inconsistencies in variable reporting and methods in larval zebrafish behavioral assays Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-02-08 Bridgett N. Hill, Katy N. Britton, Deborah L. Hunter, Jeanene K. Olin, Morgan Lowery, Joan M. Hedge, Bridget R. Knapp, Kimberly A. Jarema, Zachary Rowson, Stephanie Padilla
New approaches in developmental neurotoxicity (DNT) screening are needed due to the tens of thousands of chemicals requiring hazard assessments. Zebrafish (Danio rerio) are an alternative vertebrate model for DNT testing, but without a standardized protocol for larval behavioral assays, comparison of results among laboratories is challenging. To evaluate the congruence of protocols across laboratories
-
Factors associated with ever using cannabidiol in a cohort of younger pregnant people Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-01-27 Natacha M. De Genna, Stefanie Kennon-McGill, Lidush Goldschmidt, Gale A. Richardson, Judy C. Chang
One in four Americans have used cannabidiol (CBD) products in the past year, and use has become prevalent in many Western countries with recent deregulation from a controlled or illicit substance to an unrestricted product. CBD is also marketed to pregnant people to treat common medical conditions. However, preclinical work has linked cannabidiol exposure to embryotoxicity, as well as neuroendocrine
-
Prenatal and current phthalate exposure and cognitive development in 7-year-old children from the Odense child cohort Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-01-21 Mikkel Vilmand, Iben Have Beck, Niels Bilenberg, Anna-Maria Andersson, Anders Juul, Greet Schoeters, Henriette Boye, Hanne Frederiksen, Tina Kold Jensen
Background Phthalates are endocrine disrupters used in a variety of consumer products. Human studies suggest an association between phthalate exposure and cognitive development but adverse effects of the recently introduced phthalate substitutes have only been sparsely studied. Objectives To investigate associations between prenatal and concurrent exposure to phthalates and IQ in 7-year-old children
-
Sex-specific associations between urinary bisphenols concentrations during pregnancy and problematic child behaviors at age 2 years Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-01-13 Sarah Dee Geiger, Salma Musaad, Jennifer Hill, Andréa Aguiar, Susan Schantz
Effects of prenatal bisphenol A (BPA) exposure on child behavior are mixed with some reports suggesting increased problematic behaviors in girls (e.g., aggression and emotional reactivity) and in boys (i.e., externalizing behaviors), while other reports suggest decreased problematic behaviors in girls. Little is known about the potential impact of pregnancy bisphenol S (BPS) exposure on child behavior
-
Cognitive and functional outcomes at age 21 after prenatal cocaine/polydrug exposure and foster/adoptive care Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2023-01-06 Lynn T. Singer, Gregory Powers, June-Yung Kim, Sonia Minnes, Meeyoung O. Min
Objective Prenatal cocaine exposure (PCE) has been linked to specific cognitive deficits and behavioral outcomes through early adolescence but there is little information on adult outcomes nor on the relationship of environmental interventions, such as foster/adoptive care, to outcomes. Methods At 21 years, data were available on 325 young adults, [163 PCE and 162 non-exposed (NCE)], primarily African-American
-
Perfluorinated chemicals (PFOA) can, by interacting with highly brominated diphenyl ethers (PBDE 209) during a defined period of neonatal brain development, exacerbate neurobehavioural defects Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2022-12-27 Per Eriksson, Niclas Johansson, Henrik Viberg, Sonja Buratovic, Anders Fredriksson
Perfluorinated compounds (PFCs) and polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent environmental compounds, present in humans and at higher levels in infants/children than in adults. This study shows that co-exposure to pentadecafluorooctanoic acid (PFOA) and 2,2′,3,3′,4,4′,5,5′,6,6’-decaBDE (PBDE 209) can significantly exacerbate developmental neurobehavioural defects. Neonatal male
-
Early-life low-level lead exposure alters anxiety-like behavior, voluntary alcohol consumption and AC5 protein content in adult male and female C57BL/6 J mice Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2022-12-17 Maribel Hernández, Yanping Zhang, Gabriel M. Filippelli, Stephen L. Boehm
Despite efforts to eradicate sources of environmental lead (Pb), children, predominately in lower socioeconomic areas, are still frequently exposed to unsafe levels of Pb from soils, dust, and water. Human studies suggest that Pb exposure is associated with altered drug consumption in adults; however, there is limited research at comparable exposure levels (blood Pb levels <10 μg/dL). To model how
-
Adult and regenerating planarians respond differentially to chronic drug exposure Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2022-12-17 Kevin Bayingana, Danielle Ireland, Elizabeth Rosenthal, Christina Rabeler, Eva-Maria S. Collins
There is a lack of data on the effects of chronic exposure to common drugs and stimulants on the developing nervous system. Freshwater planarians have emerged as a useful invertebrate model amenable to high-throughput behavioral phenotyping to assay chemical safety in adult and developing brains. Here, we leverage the unique strength of the system to test in parallel for effects on the adult and developing
-
Glyphosate-based herbicide (GBH) causes damage in embryo-larval stages of zebrafish (Danio rerio) Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2022-12-07 Jaíne Ames, Eduardo Stringini Severo, Dennis Guilherme da Costa-Silva, Tamiris Rosso Storck, Aline Monique Blank do Amaral, Antônio Azambuja Miragem, Denis Broock Rosemberg, Vania Lucia Loro
-
MPTP induces neurodegeneration by modulating dopaminergic activity in catfish brain Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2022-12-05 Mamta Sajwan-Khatri, Balasubramanian Senthilkumaran
Tyrosine hydroxylase (Th) is an allosteric rate-limiting enzyme in catecholamine (CA) biosynthesis. The CAs, dopamine (DA), norepinephrine (NE), and epinephrine are important neurotransmitters wherein DA contributes a key role in the central nervous system of vertebrates. The present study evaluated DA and Th’s significance in DA-ergic activity and neurodegeneration upon 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
Adapting classic paradigms to analyze alterations of shoal-wide behavior in early-life stages of zebrafish (Danio rerio) – A case study with fluoxetine Neurotoxicol. Teratol. (IF 2.9) Pub Date : 2022-11-22 Lukas Frese, Thomas Braunbeck
Given the strong increase in prescription of neuroactive pharmaceuticals, neurotoxicity has received growing concern in science and the public. Regulatory requirements stimulated the development of new methods to evaluate the risk of neurotoxic substances for humans and the environment, and, with respect to potential damage to aquatic ecosystems, a variety of behavior-based assays have been proposed