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Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease J. Pineal. Res. (IF 10.3) Pub Date : 2024-03-16 Qian‐Kun Lv, Kang‐Xin Tao, Xiao‐Yu Yao, Meng‐Zhu Pang, Bing‐Er Cao, Chun‐Feng Liu, Fen Wang
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation of α‐synuclein (α‐syn). Ferroptosis, a form of cell death induced by iron accumulation and lipid peroxidation, is involved in the pathogenesis of PD. It is unknown whether melatonin receptor 1 (MT1) modulates α‐syn and ferroptosis in PD. Here, we used α‐syn preformed fibrils
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Correction to “Effects of melatonin on fatty liver disease: The role of NR4A1/DNA‐PKcs/p53 pathway, mitochondrial fission, and mitophagy” J. Pineal. Res. (IF 10.3) Pub Date : 2024-02-29
Zhou H, Du W, Li Y, et al. Effects of melatonin on fatty liver disease: the role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy. J Pineal Res. 2018;64:e12450. https://doi.org/10.1111/jpi.12450
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Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis J. Pineal. Res. (IF 10.3) Pub Date : 2024-02-25 Xinyue Luo, Jingjing Wang, Yang Chen, Xiaocheng Zhou, Zhe Shao, Ke Liu, Zhengjun Shang
Hyaluronic acid (HA) is a glycosaminoglycan and the main component of the extracellular matrix (ECM), which has been reported to interact with its receptor CD44 to play critical roles in the self‐renewal and maintenance of cancer stem cells (CSCs) of multiple malignancies. Melatonin is a neuroendocrine hormone with pleiotropic antitumor properties. However, whether melatonin could regulate HA accumulation
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Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats J. Pineal. Res. (IF 10.3) Pub Date : 2024-02-13 Hui Li, Bin Zhou, Jing Wu, Yuqing Zhang, Weiya Zhang, Michael Doherty, Xinjia Deng, Ning Wang, Dongxing Xie, Yilun Wang, Hui Xie, Changjun Li, Jie Wei, Guanghua Lei, Chao Zeng
Melatonin exhibits potential for pain relief and long-term safety profile. We examined the analgesic effects of oral melatonin on osteoarthritis (OA) and investigated the underlying mechanism. Using data from a UK primary care database, we conducted a cohort study in individuals with OA to compare the number of oral analgesic prescriptions and the risk of knee/hip replacement between melatonin initiators
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Correction to “Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain” J. Pineal. Res. (IF 10.3) Pub Date : 2024-02-05
Cecon E, Ivanova A, Luka M, Gbahou F, Friederich A, Guillaume JL, Keller P, Knoch K, Ahmad R, Delagrange P, Solimena M, Jockers R. Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain. J Pineal Res. 2018 Nov 26:e12540. doi:10.1111/jpi.12540 In Figure 3B, lanes for NT and mMT1 for antibody mAB-H04 were incorrect. In Figure 3C, lanes
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Greater sensitivity of the circadian system of women to bright light, but not dim-to-moderate light J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-31 Parisa Vidafar, Elise M. McGlashan, Angus C. Burns, Clare Anderson, Ari Shechter, Steven W. Lockley, Andrew J. K. Phillips, Sean W. Cain
Women typically sleep and wake earlier than men and have been shown to have earlier circadian timing relative to the light/dark cycle that synchronizes the clock. A potential mechanism for earlier timing in women is an altered response of the circadian system to evening light. We characterized individual-level dose–response curves for light-induced melatonin suppression using a within-subjects protocol
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Stable indoleamines attenuate stress—A novel paradigm in tryptophan metabolism in plants J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-31 Murali-Mohan Ayyanath, Mukund R. Shukla, Karthika Sriskantharajah, Yasmine S. Hezema, Praveen K. Saxena
Stability of metabolites in harsh environments such as drought, temperature, and light suggest their untapped potential in processes the plants utilize in mitigation of abiotic and biotic stresses. Such metabolites could be nonspecific to microorganisms, plants, or animals. Many of the indoleamines are ubiquitous throughout species and have been shown to mitigate a wide range of stresses. We tested
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Melatonin sensitizes leukemia cells to the MCL1 inhibitors S63845 and A-1210477 through multiple pathways J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-31 Kaiqin Ye, Jun Ni, Dongyan Liu, Shasha Yang, Yunjian Li, Meng Chen, Faheem Afzal Shah, Hui Chen, Wenbo Ji, Yuting Zheng, Junboya Ma, Xueran Chen, Mingjun Zhang, Naitong Sun, Haiming Dai
Several myeloid cell leukemia sequence 1 protein (MCL1) inhibitors including S64315 have undergone clinical testing for leukemia. Because of the toxicities after MCL1 inhibition, including hematopoietic, hepatic, and cardiac toxicities, there is substantial interest in finding agents that can sensitize leukemia cells to these MCL1 inhibitors. Melatonin is a chronobiotic that promotes chemo-induced
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Binding and unbinding of potent melatonin receptor ligands: Mechanistic simulations and experimental evidence J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-31 Annalida Bedini, Gian Marco Elisi, Fabiola Fanini, Michele Retini, Laura Scalvini, Silvia Pasquini, Chiara Contri, Katia Varani, Gilberto Spadoni, Marco Mor, Fabrizio Vincenzi, Silvia Rivara
The labeled ligand commonly employed in competition binding studies for melatonin receptor ligands, 2-[125I]iodomelatonin, showed slow dissociation with different half-lives at the two receptor subtypes. This may affect the operational measures of affinity constants, which at short incubation times could not be obtained in equilibrium conditions, and structure–activity relationships, as the Ki values
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Cover image J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-19 Chao Gu, Quan Zhou, Xiayu Hu, Xiaoyang Ge, Mingzhuang Hou, Wenhao Wang, Hao Liu, Qin Shi, Yong Xu, Xuesong Zhu, Huilin Yang, Xi Chen, Tao Liu, Fan He
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Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti-signalling protein (asip1) overexpression in zebrafish J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-19 Alejandra Godino-Gimeno, Esther Leal, Mauro Chivite, Elisabeth Tormos, Josep Rotllant, Daniela Vallone, Nicholas S. Foulkes, Jesús M. Míguez, Jose Miguel Cerdá-Reverter
Temporal signals such as light and temperature cycles profoundly modulate animal physiology and behaviour. Via endogenous timing mechanisms which are regulated by these signals, organisms can anticipate cyclic environmental changes and thereby enhance their fitness. The pineal gland in fish, through the secretion of melatonin, appears to play a critical role in the circadian system, most likely acting
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Melatonin as a key regulator in seed germination under abiotic stress J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-19 Lei Wang, Mohsin Tanveer, Hongling Wang, Marino B. Arnao
Seed germination (SG) is the first stage in a plant's life and has an immense importance in sustaining crop production. Abiotic stresses reduce SG by increasing the deterioration of seed quality, and reducing germination potential, and seed vigor. Thus, to achieve a sustainable level of crop yield, it is important to improve SG under abiotic stress conditions. Melatonin (MEL) is an important biomolecule
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N1-Acetyl-5-methoxykynuramine, which decreases in the hippocampus with aging, improves long-term memory via CaMKII/CREB phosphorylation J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-12 Kazuki Watanabe, Yusuke Maruyama, Hikaru Iwashita, Haruyasu Kato, Jun Hirayama, Atsuhiko Hattori
Melatonin is a molecule ubiquitous in nature and involved in several physiological functions. In the brain, melatonin is converted to N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and then to N1-acetyl-5-methoxykynuramine (AMK), which has been reported to strongly enhance long-term object memory formation. However, the synthesis of AMK in brain tissues and the underlying mechanisms regarding memory
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Circadian misalignment impairs oligodendrocyte myelination via Bmal1 overexpression leading to anxiety and depression-like behaviors J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-12 Yao Zuo, Yuanyuan Hou, Yunlei Wang, Linran Yuan, Lingna Cheng, Tong Zhang
Circadian misalignment (CM) caused by shift work can increase the risk of mood impairment. However, the pathological mechanisms underlying these deficits remain unclear. In the present study, we used long-term variable photoperiod (L-VP) in wild-type mice to better simulate real-life shift patterns and study its effects on the prefrontal cortex (PFC) and hippocampus, which are closely related to mood
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Melatonin suppression by light involves different retinal photoreceptors in young and older adults J. Pineal. Res. (IF 10.3) Pub Date : 2024-01-08 Raymond P. Najjar, Abhishek S. Prayag, Claude Gronfier
Age-related sleep and circadian rhythm disturbances may be due to altered nonvisual photoreception. Here, we investigated the temporal dynamics of light-induced melatonin suppression in young and older individuals. In a within-subject design study, young and older participants were exposed for 60 min (0030-0130 at night) to nine narrow-band lights (range: 420−620 nm). Plasma melatonin suppression was
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Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems J. Pineal. Res. (IF 10.3) Pub Date : 2023-12-26 Jean A. Boutin, Maxime Liberelle, Saïd Yous, Gilles Ferry, Françoise Nepveu
Melatonin is a small natural compound, so called a neuro-hormone that is synthesized mainly in pineal gland in animals. Its main role is to master the clock of the body, under the surveillance of light. In other words, it transfers the information concerning night and day to the peripheral organs which, without it, could not “know” which part of the circadian rhythm the body is in. Besides its main
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An independent comparison of the Novolytix salivary melatonin radioimmunoassay with the new Novolytix salivary melatonin enzyme-linked immunosorbent assay J. Pineal. Res. (IF 10.3) Pub Date : 2023-12-18 Helen J. Burgess, David Kagan, Muneer Rizvydeen, Leslie M. Swanson, Hyungjin M. Kim
The dim light melatonin onset (DLMO) is the current gold standard biomarker of the timing of the central circadian clock in humans and is often assessed from saliva samples. To date, only one commercially available salivary melatonin assay is considered accurate at the low daytime levels required to accurately detect the DLMO (Novolytix RIA RK-DSM2). The aim of this study was to conduct the first independent
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Fate of melatonin orally administered in preterm newborns: Antioxidant performance and basis for neuroprotection J. Pineal. Res. (IF 10.3) Pub Date : 2023-12-18 Francesca Garofoli, Valentina Franco, Patrizia Accorsi, Riccardo Albertini, Micol Angelini, Carlo Asteggiano, Salvatore Aversa, Elena Ballante, Renato Borgatti, Raffaella F. Cabini, Camilla Caporali, Luisa Chiapparini, Sara Cociglio, Elisa Fazzi, Stefania Longo, Laura Malerba, Valeria Materia, Laura Mazzocchi, Cecilia Naboni, Michela Palmisani, Anna Pichiecchio, Lorenzo Pinelli, Camilla Pisoni, Lorenzo
Preterm infants cannot counteract excessive reactive oxygen species (ROS) production due to preterm birth, leading to an excess of lipid peroxidation with malondialdehyde (MDA) production, capable of contributing to brain damage. Melatonin (ME), an endogenous brain hormone, and its metabolites, act as a free radical scavenger against ROS. Unfortunately, preterms have an impaired antioxidant system
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Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved J. Pineal. Res. (IF 10.3) Pub Date : 2023-12-11 Daniel P. Cardinali
Because the chronobiotic and cytoprotective molecule melatonin diminishes with age, its involvement in postmenopausal and senescence pathology has been considered since long. One relevant melatonin target site in aging individuals is bone where melatonin chronobiotic effects mediated by MT1 and MT2 receptors are demonstrable. Precursors of bone cells located in bone marrow are exposed to high quantities
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Melatonin improves cholestatic liver disease via the gut-liver axis J. Pineal. Res. (IF 10.3) Pub Date : 2023-12-04 Xianjiao Liu, Jinyan Li, Mengdie Shi, Jun Fu, Yubo Wang, Weili Kang, Jinyan Liu, Fenxia Zhu, Kehe Huang, Xingxiang Chen, Yunhuan Liu
Cholestatic liver disease is characterized by disturbances in the intestinal microbiota and excessive accumulation of toxic bile acids (BA) in the liver. Melatonin (MT) can improve liver diseases. However, the underlying mechanism remains unclear. This study aimed to explore the mechanism of MT on hepatic BA synthesis, liver injury, and fibrosis in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed
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Hypnotic effects of melatonin depend on the environmental lighting conditions in the rat J. Pineal. Res. (IF 10.3) Pub Date : 2023-11-29 Yumeng Wang, Tom Deboer
Acute effects of exogenous melatonin have been widely reported to promote sleep or induce drowsiness in human. However, testing of the hypnotic effects of melatonin in nocturnal rodents has yielded contradictory results. The latter may be associated with differences in concentration, lighting conditions, time of administration of melatonin, and possibly the type of analysis. In this study, electroencephalogram
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Cross-species single-cell landscape of vertebrate pineal gland J. Pineal. Res. (IF 10.3) Pub Date : 2023-11-28 Jihong Zheng, Wenqi Song, Yihang Zhou, Xuan Li, Meng Wang, Chao Zhang
The pineal gland has evolved from a photoreceptive organ in fish to a neuroendocrine organ in mammals. This study integrated multiple daytime single-cell RNA-seq datasets from the pineal glands of zebrafish, rats, and monkeys, providing a detailed examination of the evolutionary transition at single-cell resolution. We identified key factors responsible for the anatomical and functional transformation
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IL-10-induced STAT3/NF-κB crosstalk modulates pineal and extra-pineal melatonin synthesis J. Pineal. Res. (IF 10.3) Pub Date : 2023-11-22 Marlina O. Córdoba-Moreno, Gabriela Christine Santos, Sandra M. Muxel, Débora dos Santos-Silva, Caroline L. Quiles, Kassiano D. S. Sousa, Regina P. Markus, Pedro Augusto C. M. Fernandes
Immune-pineal axis activation is part of the assembly of immune responses. Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in macrophages by mechanisms dependent on nuclear factor-κB (NF-κB) activation. Cytokines activating the Janus kinase/signal transducer and activator of transcription (STAT) pathways, such as interferon-gamma (IFN-γ) and interleukin-10 (IL-10)
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The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke J. Pineal. Res. (IF 10.3) Pub Date : 2023-11-20 Xinmu Zhang, Bin Peng, Shenqi Zhang, Jian Wang, Xiong Yuan, Sharon Peled, Wu Chen, Jinyin Ding, Wei Li, Andrew Zhang, Qiaofeng Wu, Irina G. Stavrovskaya, Chengliang Luo, Bharati Sinha, Yanyang Tu, Xiaojing Yuan, Mingchang Li, Shuqing Liu, Jianfang Fu, Ali Aziz-Sultan, Bruce S. Kristal, Gil Alterovitz, Rose Du, Shuanhu Zhou, Xin Wang
Stroke is the leading cause of death and disability worldwide. Novel and effective therapies for ischemic stroke are urgently needed. Here, we report that melatonin receptor 1A (MT1) agonist ramelteon is a neuroprotective drug candidate as demonstrated by comprehensive experimental models of ischemic stroke, including a middle cerebral artery occlusion (MCAO) mouse model of cerebral ischemia in vivo
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Melatonin rescues the mitochondrial function of bone marrow-derived mesenchymal stem cells and improves the repair of osteoporotic bone defect in ovariectomized rats J. Pineal. Res. (IF 10.3) Pub Date : 2023-11-08 Chao Gu, Quan Zhou, Xiayu Hu, Xiaoyang Ge, Mingzhuang Hou, Wenhao Wang, Hao Liu, Qin Shi, Yong Xu, Xuesong Zhu, Huilin Yang, Xi Chen, Tao Liu, Fan He
Osteoporotic bone defects, a severe complication of osteoporosis, are distinguished by a delayed bone healing process and poor repair quality. While bone marrow-derived mesenchymal stem cells (BMMSCs) are the primary origin of bone-forming osteoblasts, their mitochondrial function is impaired, leading to inadequate bone regeneration in osteoporotic patients. Melatonin is well-known for its antioxidant
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Safety and efficacy of melatonin supplementation as an add-on treatment for infantile epileptic spasms syndrome: A randomized, placebo-controlled, double-blind trial J. Pineal. Res. (IF 10.3) Pub Date : 2023-11-01 Yulin Sun, Jian Chen, Xiuyu Shi, Zhichao Li, Lin Wan, Huimin Yan, Yuehao Chen, Jiaxin Wang, Jing Wang, Liping Zou, Russel Reiter, Bo Zhang, Guang Yang
This was a prospective, randomized, double-blind, single-center placebo-controlled trial to assess the efficacy and safety of melatonin as an add-on treatment for infantile epileptic spasms syndrome (IESS). Participants aged 3 months to 2 years with a primary diagnosis of IESS were recruited and assigned to two groups in a 1:1 ratio. Both treatment groups received a combination of adrenocorticotrophic
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Ramelteon attenuates hippocampal neuronal loss and memory impairment following kainate-induced seizures J. Pineal. Res. (IF 10.3) Pub Date : 2023-10-17 Jung Hoon Park, Yeonggwang Hwang, Yen Nhi Doan Nguyen, Hyoung-Chun Kim, Eun-Joo Shin
Evidence suggests that the neuroprotective effects of melatonin involve both receptor-dependent and -independent actions. However, little is known about the effects of melatonin receptor activation on the kainate (KA) neurotoxicity. This study examined the effects of repeated post-KA treatment with ramelteon, a selective agonist of melatonin receptors, on neuronal loss, cognitive impairment, and depression-like
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Melatonin suppresses tumor proliferation and metastasis by targeting GATA2 in endometrial cancer J. Pineal. Res. (IF 10.3) Pub Date : 2023-10-09 Yangyou Liao, Ruiling Li, Jingyuan Pei, Juan Zhang, Bo Chen, Haojie Dong, Xiaoyu Feng, Hongshuo Zhang, Yuhong Shang, Linlin Sui, Ying Kong
Endometrial cancer (EC) is a reproductive system disease that occurs in perimenopausal and postmenopausal women. However, its etiology is unclear. Melatonin (MT) has been identified as a therapeutic agent for EC; however, its exact mechanism remains unclear. In the present study, we determined that GATA-binding protein 2 (GATA2) is expressed at low levels in EC and regulated by MT. MT upregulates the
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Erratum to: Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells J. Pineal. Res. (IF 10.3) Pub Date : 2023-10-03
DOI: 10.1111/jpi.12478 Zhenlong Yu1,+, Xiangge Tian1,+, Yuling Peng1,+, Zheng Sun1, Chao Wang 1, Ning Tang1, Bin Li2, Yuqing Jian2, Wei Wang2,*, Xiaokui Huo1, Xiaochi Ma1,* *Correspondence: Professor Xiaochi Ma, E-mail: maxc1978@163.com (Xiaochi Ma); Professor Wei Wang, E-mail: wangwei402@hotmail.com (Wei Wang). +These authors equally contributed to this work. Correction: Unfortunately, the original
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Melatonin alters the excitability of mouse cerebellar granule neurons by inhibiting voltage-gated sodium, potassium, and calcium channels J. Pineal. Res. (IF 10.3) Pub Date : 2023-10-05 Karolos-Philippos Pissas, Maria Schilling, Ahmet Korkmaz, Yuemin Tian, Stefan Gründer
Besides its role in the circadian rhythm, the pineal gland hormone melatonin (MLT) also possesses antiepileptogenic, antineoplastic, and cardioprotective properties, among others. The dosages necessary to elicit beneficial effects in these diseases often far surpass physiological concentrations. Although even high doses of MLT are considered to be largely harmless to humans, the possible side effects
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Melatonin prevents EAAC1 deletion-induced retinal ganglion cell degeneration by inhibiting apoptosis and senescence J. Pineal. Res. (IF 10.3) Pub Date : 2023-10-03 Chenyang Hu, Yanlin Feng, Guangyi Huang, Kaixuan Cui, Matthew Fan, Wu Xiang, Yuxun Shi, Dan Ye, Huiwen Ye, Xue Bai, Fan Xu, Yue Xu, Jingjing Huang
Normal tension glaucoma (NTG) is referred to as a progressive degenerative disorder of the retinal ganglion cells (RGCs), resulting in nonreversible visual defects, despite intraocular pressure levels within the statistically normal range. Current therapeutic strategies for NTG yield limited benefits. Excitatory amino acid carrier 1 (EAAC1) knockout (EAAC1−/−) in mice has been shown to induce RGC degeneration
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Melatonin, a potentially effective drug for the treatment of infected bone nonunion J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-27 Han-jun Qin, Si-ying He, Ke Shen, Qing-rong Lin, Yan-jun Hu, Zi-lin Chen, Bin Yu, Nan Jiang
Osteomyelitis (OM), characterized by heterogeneity and complexity in treatment, has a high risk of infection recurrence which may cause limb disability. Management of chronic inactive osteomyelitis (CIOM) without typical inflammatory symptoms is a great challenge for orthopedic surgeons. On the basis of data analysis of 1091 OM cases, we reported that latent osteogenic decline in CIOM patients was
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Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-25 Xuan Shao, Yun Yang, Yanlei Liu, Yongqing Wang, Yangyu Zhao, Xin Yu, Juan Liu, Yu-Xia Li, Yan-Ling Wang
Maintaining placental endocrine homeostasis is crucial for a successful pregnancy. Pre-eclampsia (PE), a gestational complication, is a leading cause of maternal and perinatal morbidity and mortality. Aberrant elevation of testosterone (T0) synthesis, reduced estradiol (E2), and melatonin productions have been identified in preeclamptic placentas. However, the precise contribution of disrupted homeostasis
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Corrigendum to “melatonin ameliorates PM2.5-induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis” J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-20
After publication of the paper “Melatonin ameliorates PM2.5-induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis” by Jinjin Jiang et al. it was noticed that the paper contains error in Figure 4D and Figure 6D. During the assembly of certain figure panel of this article showing representative immunoblot, Ac-SOD2 and GPADH (Figure 4D) and GAPDH (Figure 6D) were presented
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Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-18 Jinho Kim, Wei Li, Jingjing Wang, Sergei V. Baranov, Brianna E. Heath, Jiaoying Jia, Yalikun Suofu, Oxana V. Baranova, Xiaomin Wang, Timothy M. Larkin, William R. Lariviere, Diane L. Carlisle, Robert M. Friedlander
Huntington's disease (HD) is a progressive neurodegenerative brain disorder associated with uncontrolled body movements, cognitive decline, and reduced circulating melatonin levels. Melatonin is a potent antioxidant and exogenous melatonin treatment is neuroprotective in experimental HD models. In neurons, melatonin is exclusively synthesized in the mitochondrial matrix. Thus, we investigated the integrity
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Correction to human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-11
Huo X, Wang C, Yu Z, Peng Y, Wang S, Feng S, Zhang S, Tian X, Sun C, Liu K, Deng S, Ma X. Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential. J Pineal Res. 2017;62(4):12390. https://doi.org/10.1111/jpi.12390 In Figure 10B, the C-casp3 bands of PC3 cells and Bax bands of U118 cells were accidentally wrongly
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iMS-Bmal1−/− mice show evident signs of sarcopenia that are counteracted by exercise and melatonin therapies J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-13 José Fernández-Martínez, Yolanda Ramírez-Casas, Paula Aranda-Martínez, Alba López-Rodríguez, Ramy K. A. Sayed, Germaine Escames, Darío Acuña-Castroviejo
Sarcopenia is an age-related disease characterized by a reduction in muscle mass, strength, and function and, therefore, a deterioration in skeletal muscle health and frailty. Although the cause of sarcopenia is still unknown and, thus, there is no treatment, increasing evidence suggests that chronodisruption, particularly alterations in Bmal1 clock gene, can lead to those deficits culminating in sarcopenia
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Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification J. Pineal. Res. (IF 10.3) Pub Date : 2023-09-13 Filippo Gagliardi, Pierfrancesco De Domenico, Enrico Garbin, Silvia Snider, Pietro Mortini
Pineal region tumors (PTs) represent extremely rare pathologies, characterized by highly heterogeneous histological patterns. Most of the available evidence for Gamma Knife radiosurgical (GKSR) treatment of PTs arises from multimodal regimens, including GKSR as an adjuvant modality or as a salvage treatment at recurrence. We aimed to gather existing evidence on the topic and analyze single-patient-level
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The mammalian gastro-intestinal tract is a NOT a major extra-pineal source of melatonin J. Pineal. Res. (IF 10.3) Pub Date : 2023-08-31 David J. Kennaway
In 1992, a paper reported that the melatonin content of the rat duodenum was 24 000 ± 2000 pg/g tissue (range: 4000–100 000 pg/g) while the pineal melatonin content was 580 000 ± 36 000 pg/g. The data has been used for the last 30 years to infer that the gut produces 400 hundred times more melatonin than the pineal gland and that it is the source of plasma melatonin during the daytime. No-one has ever
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From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin J. Pineal. Res. (IF 10.3) Pub Date : 2023-08-31 Natalia Méndez, Fernando Corvalan, Diego Halabi, Pamela Ehrenfeld, Rodrigo Maldonado, Karina Vergara, Maria Seron-Ferre, Claudia Torres-Farfan
During gestation, the developing fetus relies on precise maternal circadian signals for optimal growth and preparation for extrauterine life. These signals regulate the daily delivery of oxygen, nutrients, hormones, and other biophysical factors while synchronizing fetal rhythms with the external photoperiod. However, modern lifestyle factors such as light pollution and shift work can induce gestational
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The ISL LIM-homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland J. Pineal. Res. (IF 10.3) Pub Date : 2023-08-30 Kuno M.-J. Mattern, Aurea S. Blancas-Velázquez, Mikaella T. Ngo, Signe Bille, Henrik Hertz, Tenna Bering, Martin F. Rath
Melatonin is synthesized in the pineal gland during nighttime in response to nocturnal increase in the activity of the enzyme aralkylamine N-acetyltransferase (AANAT), the transcription of which is modulated by several homeodomain transcription factors. Recent work suggests that the homeodomain transcription factor ISL LIM homeobox 2 (ISL2) is expressed in the pineal gland, but its role is currently
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Differentiation of T cells producing interleukin-17 (Th17) against the background of exogenous melatonin during pregnancy J. Pineal. Res. (IF 10.3) Pub Date : 2023-08-21 Natalya Sergeevna Glebezdina, Irina Valerievna Nekrasova, Anna Alexandrovna Olina, Gulnara Kamilyevna Sadykova, Elena Michajlovna Kuklina
The population of T lymphocytes producing IL-17 (Th17) plays a dual role during pregnancy and its activity is tightly controlled during this period. One of the factors involved in this process may be the pineal hormone melatonin, which can effectively regulate this T cell population. Here we have shown that exogenous melatonin in pharmacological concentrations is able to enhance the differentiation
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Correction to high sensitivity of melatonin suppression response to evening light in preschool-aged children J. Pineal. Res. (IF 10.3) Pub Date : 2023-08-16
Hartstein, LE, Behn, CD, Akacem, LD, Stack, N, Wright, KP, LeBourgeois, MK. High sensitivity of melatonin suppression response to evening light in preschool-aged children. J Pineal Res. 2022; 72:e12780. doi:10.1111/jpi.12780 The funding information from the National Heart, Lung, and Blood Institute of the National Institutes of Health was erroneously omitted in the article. The complete funding information
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Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design J. Pineal. Res. (IF 10.3) Pub Date : 2023-07-26 Lei Chen, Tao Sun, Yongning Lv, Xin Lu, Xixuan Li, Hongsen Zhang, Kun Qian, Xiaopeng Guo, Bo Sun, Weihua Zhang, Licheng Zhu, Jia Huang, Yiming Liu, Huangxuan Zhao, Yanbin Zhao, Bin Liang, Chuansheng Zheng
Transarterial chemoembolization (TACE) has been widely used for hepatocellular carcinoma. Reducing hypoxia in the tumor microenvironment after TACE remains a challenge as tumor progression is common in post-TACE patients due to the hypoxic tumor microenvironment. In this study, melatonin loaded on p(N-isopropyl-acrylamide-co-butyl methylacrylate) (PIB-M) was used for tumor embolism. Two types of human
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Angiogenesis, coagulation, and fibrinolytic markers in acute promyelocytic leukemia (NB4): An evaluation of melatonin effects J. Pineal. Res. (IF 10.3) Pub Date : 2023-07-24 Mohammad Reza Amirzargar, Fahimeh Shahriyary, Minoo Shahidi, Ahmad Kooshari, Mahshid Vafajoo, Reza Nekouian, Mohammad Faranoush
Melatonin is a powerful biological agent that has been shown to inhibit angiogenesis and also exerts anti-inflammatory effects. It is well known that new blood vessel formation (angiogenesis) has become an urgent issue in leukemia as well as solid tumors. Acute promyelocytic leukemia (APL) is a form of liquid cancer that manifests increased angiogenesis in the bone marrow of patients. Despite high-rate
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Melatonin in food allergy: Mechanism and potential therapy J. Pineal. Res. (IF 10.3) Pub Date : 2023-07-21 Hao Wang, Yuqi Yan, Ifen Hung, Chunxue Liu, Jie Yin, Liangpeng Ge, Wenkai Ren
Food allergy affects more than 500 million people in the world, and its prevalence is increasing at an alarming rate causing serious public health concerns; however, prevention and treatment methods are still under investigation and are relatively scarce so far. Insights on pathophysiology reveal a complex interplay of the immune cells (e.g., DCs, T cells, and B cells) resulting in allergy or tolerance
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Melatonin targets MoIcl1 and works synergistically with fungicide isoprothiolane in rice blast control J. Pineal. Res. (IF 10.3) Pub Date : 2023-07-17 Ruiqing Bi, Renjian Li, Zhenyi Xu, Huanyu Cai, Juan Zhao, Yaru Zhou, Bangting Wu, Peng Sun, Wei Yang, Lu Zheng, Xiao-Lin Chen, Chao-Xi Luo, Huailong Teng, Qiang Li, Guotian Li
Melatonina natural harmless molecule—displays versatile roles in human health and crop disease control such as for rice blast. Rice blast, caused by the filamentous fungus Magnaporthe oryzae, is one devastating disease of rice. Application of fungicides is one of the major measures in the control of various crop diseases. However, fungicide resistance in the pathogen and relevant environmental pollution
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Disruption of serotonin biosynthesis increases resistance to striped stem borer without changing innate defense response in rice J. Pineal. Res. (IF 10.3) Pub Date : 2023-07-01 Long Wang, Haiping Lu, Xiaoyan Zhang, Yuxin He, Jiarun Zhang, Xiaohao Guo, Haowei Fu, Gongyin Ye, Qingyao Shu
Striped stem borer (SSB) is one of the most damaging pests in rice production worldwide. Previously, we preliminarily demonstrated that indica rice Jiazhe LM, an OsT5H (encoding tryptamine-5-hydroxylase) knockout mutant deficient in serotonin, had increased resistance to SSB as compared with its wildtype parent Jiazhe B. However, the full scenario of SSB resistance and the underlying mechanism remain
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Amelioration of gamma irradiation-induced salivary gland damage in mice using melatonin J. Pineal. Res. (IF 10.3) Pub Date : 2023-06-30 Jingming Ren, Tong Zhu, Zhouxuan Wang, Lu Lu, Saijun Fan
Salivary gland damage caused by ionizing radiation (IR) severely affects the patient quality of life and influences the efficacy of radiotherapy. Most current treatment modalities are palliative, so effective prevention of damage caused by IR is essential. Melatonin (MLT) is an antioxidant that has been reported to prevent IR-induced damage in a range of systems, including the hematopoietic system
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Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC-α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm J. Pineal. Res. (IF 10.3) Pub Date : 2023-06-26 Megha Das, Chandana Haldar, Sanjeev Kumar Yadav
Female night-workers get exposed to frequent light shifts, hence have altered circadian rhythm and are at high risk of endometrial cancer; the underlying mechanism however is still not clear. We, therefore examined the effect of long light exposure (16L:8D, LD1) and regular shift (8 h) in long nighttime (LD2) on endometrial changes of female golden hamsters. Morphometric analysis, scanning electron
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Role and neural regulation of clock genes in the rat pineal gland: Clock modulates amplitude of rhythmic expression of Aanat encoding the melatonin-producing enzyme J. Pineal. Res. (IF 10.3) Pub Date : 2023-06-22 Aurea S. Blancas-Velazquez, Tenna Bering, Signe Bille, Martin F. Rath
Circadian clock gene expression in the suprachiasmatic nucleus (SCN) controls 24 h rhythms in body functions, but clock genes are also expressed in extra-hypothalamic tissues, including the melatonin-producing pineal gland. The nocturnal increase in pineal melatonin synthesis is a hallmark in circadian biology, but the role of local clock gene oscillations in the mammalian pineal gland is unknown.
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Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study J. Pineal. Res. (IF 10.3) Pub Date : 2023-06-15 Yongkang Zhen, Yifan Wang, Feiyang He, Yifei Chen, Liangyu Hu, Ling Ge, Yusu Wang, Wenjun Wei, Ali Rahmat, Juan J. Loor, Mengzhi Wang
The accelerated pace of life at present time has resulted in tremendous alterations in living patterns. Changes in diet and eating patterns, in particular, coupled with irregular light–dark (LD) cycles will further induce circadian misalignment and lead to disease. Emerging data has highlighted the regulatory effects of diet and eating patterns on the host-microbe interactions with the circadian clock
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MdMPK3 and MdMPK6 fine-tune MdWRKY17-mediated transcriptional activation of the melatonin biosynthesis gene MdASMT7 J. Pineal. Res. (IF 10.3) Pub Date : 2023-06-06 Handong Song, Yanzhao Sun, Dongqian Shan, Tong Zhang, Chanyu Wang, Tianci Yan, Zehui Hu, Yixue Bai, Ruoxue Li, Changjian Dai, Qian Deng, Yixuan Zhao, Yan Guo, Jin Kong
Melatonin (N-acetyl-5-methoxytryptamine) is a potent reactive oxygen species (ROS) scavenger that increases the biotic and abiotic stress tolerance in plants. The signaling and regulation pathways of melatonin in plants remain elusive. Here, we report that transgenic apple (Malus domestica) plants overexpressing the transcription factor gene, MdWRKY17, have higher melatonin contents and lower ROS levels
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Effect of melatonin on ATG2B-mediated autophagy regulation in sheep granulosa cells with different FecB genotypes J. Pineal. Res. (IF 10.3) Pub Date : 2023-05-24 Yu-Fang Liu, Zi-Yi Liu, Wen-Tao Li, Peng Wang, Xiang-Yu Wang, Ran Di, Xiao-Yun He, Ming-Xing Chu
Melatonin (MLT) protects cells by reducing reactive oxygen species (ROS) levels, which are key for inducing cellular autophagy. The aim of this study was to investigate the molecular mechanisms underlying MLT regulation of autophagy in granulosa cells (GCs) with BMPR-1B homozygous (FecB BB) and wild type (FecB ++) mutations. GCs collected from small-tailed Han sheep with different FecB genotypes were
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RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats J. Pineal. Res. (IF 10.3) Pub Date : 2023-05-14 Hui Yang, Zubin Zhang, Xin Ding, Xiaolu Jiang, Lanlan Tan, Chenjie Lin, Lixiao Xu, Gen Li, Lianghua Lu, Zhenghong Qin, Xing Feng, Mei Li
Hypoxia-ischemia (HI) of the brain not only impairs neurodevelopment but also causes pineal gland dysfunction, which leads to circadian rhythm disruption. However, the underlying mechanism of circadian rhythm disruption associated with HI-induced pineal dysfunction remains unknown. The zinc finger protein repressor protein with a predicted molecular mass of 58 kDa (RP58) is involved in the development
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Effects of melatonin on cardiac metabolic reprogramming in doxorubicin-induced heart failure rats: A metabolomics study for potential therapeutic targets J. Pineal. Res. (IF 10.3) Pub Date : 2023-05-13 Chanisa Thonusin, Wichwara Nawara, Apiwan Arinno, Thawatchai Khuanjing, Nanthip Prathumsup, Benjamin Ongnok, Siriporn C. Chattipakorn, Nipon Chattipakorn
Using mass spectrometry-based targeted metabolomics, we aimed to determine the pattern of cardiac metabolic reprogramming and energetics in doxorubicin-induced heart failure. More importantly, we aimed to identify the potential effects of melatonin on cardiac metabolic reprogramming and energetics in doxorubicin-induced heart failure. Male Wistar rats (n = 18) were randomly divided into three groups
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Arylalkylamine N-acetyltransferase (AANAT): Blue light induction, nuclear translocation, and potential role in the survival of chicken retina neuronal cells J. Pineal. Res. (IF 10.3) Pub Date : 2023-04-18 Maximiliano N. Rios, Natalia A. Marchese, Mario E. Guido
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Melatonin inhibits chondrosarcoma cell proliferation and metastasis by enhancing miR-520f-3p production and suppressing MMP7 expression J. Pineal. Res. (IF 10.3) Pub Date : 2023-04-14 Bao Tran Nguyen, Chih-Yang Lin, Ting-Kuo Chang, Yi-Chin Fong, Louis Anoop Thadevoos, Chao-Yang Lai, Yuan-Li Huang, Chun-Hao Tsai, Chih-Yuan Ko, Ju-Fang Liu, Shun-Fa Yang, Chih-Hsin Tang
Chondrosarcoma has a high propensity to metastasize and responds poorly to chemotherapy and radiation treatment. The enzymatic activity of matrix metalloproteinases (MMPs) is very important in chondrosarcoma metastasis. Melatonin exhibits anticarcinogenic activity in many types of cancers by suppressing the expression of certain MMP family members, but this has not yet been clearly determined in chondrosarcoma
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Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double-blind, randomized, placebo-controlled trial J. Pineal. Res. (IF 10.3) Pub Date : 2023-04-13 Dennis Zetner, Claus Kamby, Camilla Christophersen, Sengül Gülen, Cecilie B. Paulsen, Emily Piga, Bodil Hoffmeyer, Faisal Mahmood, Jacob Rosenberg
This was a double-blind, placebo-controlled randomized study investigating whether melatonin can protect against radiation dermatitis in women receiving radiation therapy for primary breast cancer.
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Melatonin improves skin barrier damage caused by sleep restriction through gut microbiota J. Pineal. Res. (IF 10.3) Pub Date : 2023-04-13 Weitian Li, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
It is widely known that lack of sleep damages the skin. Therefore, it is necessary to explore the relationship between sleep deprivation and skin damage and to find effective treatments. We established a 28-day sleep restriction (SR) mice model simulating continuous long-term sleep loss. We found that SR would damage the barrier function of mice's skin, cause oxidative stress damage to the skin, weaken