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Beyond boundaries: investigating shared and divergent connectivity in the pre-/postcentral gyri and supplementary motor area. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Adnan A S Alahmadi
This study aimed to comprehensively investigate the functional connectivity of key brain regions involved in motor and sensory functions, namely the precentral gyrus, postcentral gyrus and supplementary motor area (SMA). Using advanced MRI, the objective was to understand the neurophysiological integrative characterizations of these regions by examining their connectivity with eight distinct functional
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Gender differences in pedestrian hazard perception: evidence from an event-related potential study. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Peng Zhu, Min Ma
Gender differences in pedestrian hazard perception were investigated using the event-related potential technique.
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Sophora flavescens alcohol extract ameliorates insomnia and promotes PI3K/AKT/BDNF signaling transduction in insomnia model rats. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Yanyan Wu, Chenhang Yao, Lan Zhang, Guoqing Wu
Active ingredient of Sophora flavescens is reported to promote non-rapid eye movement (NREM) sleep. However, the role of Sophora flavescens alcohol extract in insomnia is elusive, which is addressed in this study, together with the exploration on its potential mechanism. An insomnia model of rats was established by para-chlorophenylalanine induction and further treated with SFAE or Zaoren Anshen capsule
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Adaptation-induced sharpening of orientation tuning curves in the mouse visual cortex. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Afef Ouelhazi, Vishal Bharmauria, Stéphane Molotchnikoff
Orientation selectivity is an emergent property of visual neurons across species with columnar and noncolumnar organization of the visual cortex. The emergence of orientation selectivity is more established in columnar cortical areas than in noncolumnar ones. Thus, how does orientation selectivity emerge in noncolumnar cortical areas after an adaptation protocol? Adaptation refers to the constant presentation
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Neural correlates of processing active and passive sentences: proficiency-dependent event-related potential evidence in Chinese English foreign language learners. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Tao Wang, Keyi Yin, Xing Wang, Man Wang
We explored whether and to what extent the neural mechanisms of second language sentence processing resemble those of native speakers by investigating the temporal dynamics of syntactic processing in terms of active or passive voice in reading English sentences by Chinese English Foreign Language (EFL) learners with high or low English proficiency. Participants were divided into two groups based on
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Analysis of the lncRNA-miRNA-mRNA network to explore the regulation mechanism in human traumatic brain injury. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Xuefei Shao, Maosong Zhang, Jincheng Fang, Ruixiang Ge, Yue Su, Hongbing Liu, Daojin Zhang, Qifu Wang
Traumatic brain injury (TBI) refers to brain dysfunction with or without traumatic structural injury induced by an external force. Nevertheless, the molecular mechanism of TBI remains undefined. Differentially expressed (DE) lncRNAs, DEmRNAs and DEmiRNAs were selected between human TBI tissues and the adjacent histologically normal tissue by high-throughput sequencing. Gene ontology enrichment analysis
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Altered dynamic and static brain activity and functional connectivity in COVID-19 patients: a preliminary study. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Mingxing Han, Chunni He, Tianping Li, Qinglong Li, Tongpeng Chu, Jun Li, Peiyuan Wang
This study aimed to investigate the effects of COVID-19 on brain functional activity through resting-state functional MRI (rs-fMRI). fMRI scans were conducted on a cohort of 42 confirmed COVID-19-positive patients and 46 healthy controls (HCs) to assess brain functional activity. A combination of dynamic and static amplitude of low-frequency fluctuations (dALFF/sALFF) and dynamic and static functional
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Sortilin inhibition in microglial cells cannot alleviate ischemia and hypoxia-induced neuronal injury in co-culture. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Shuang Long, Zhao Liu, Yan Wang
Sortilin is a single-pass type I transmembrane protein which can bind to various cargo proteins, regulating their surface location, secretion, or degradation in lysosomes. In our previous study, we found that sortilin can regulate progranulin expression by transporting it to lysosomes and reduce neuronal cell injury in hypoxia-ischemia, but the expression and function of sortilin in microglial cells
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Auditory influence on stickiness perception: an fMRI study of multisensory integration. Neuroreport (IF 1.7) Pub Date : 2024-02-02 In-Seon Lee, Jae-Hwan Kang, Junsuk Kim
This study explored how the human brain perceives stickiness through tactile and auditory channels, especially when presented with congruent or incongruent intensity cues. In our behavioral and functional MRI (fMRI) experiments, we presented participants with adhesive tape stimuli at two different intensities. The congruent condition involved providing stickiness stimuli with matching intensity cues
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Electroacupuncture alleviates streptozotocin-induced diabetic neuropathic pain via suppressing phosphorylated CaMKIIα in rats. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Siyi Li, Yinmu Zheng, Yurong Kang, Xiaofen He, Yu Zheng, Minjian Jiang, Xinnan Xu, Liqian Ma, Xiaoxiang Wang, Kunlong Zhang, Xiaomei Shao, Jianqiao Fang, Yongliang Jiang
Diabetic neuropathic pain (DNP) is a frequent complication of diabetes. Calcium/calmodulin-dependent protein kinase II α (CaMKIIα), a multi-functional serine/threonine kinase subunit, is mainly located in the surface layer of the spinal cord dorsal horn (SCDH) and the primary sensory neurons in dorsal root ganglion (DRG). Numerous studies have indicated electroacupuncture (EA) takes effect in various
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Effects of hazard type and confidence level on hazard perception in young male drivers: an ERP study. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Long Sun, Wen-Jing Hu, Liang Cheng, Chang-Lu Zhang
Hazard perception refers to a driver's ability to identify potential hazards on the road. Although studies have shown that overconfidence affects drivers' ability to perceive hazards, the neural processing of hazard perception in overconfident drivers under different hazard types has rarely been investigated. A mixed experimental design of 2 (hazard type: hazards, no hazards) × 2 (driver group: overconfident
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Myelin basic proteins charge isomers interact differently with the peptidyl arginine deiminase-2. Neuroreport (IF 1.7) Pub Date : 2024-01-31 Nino Mamulashvili, Marika Chikviladze, Lali Shanshiashvili, David Mikeladze
The deamination of arginine and its conversion to citrulline is a modification observed in positively charged proteins such as histones or myelin basic protein (MBP). This reaction is catalyzed by peptidyl arginine deiminase (PAD), whose abnormal activation is associated with autoimmune diseases like rheumatoid arthritis and multiple sclerosis. However, the mechanisms that trigger PAD activation and
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GSK-3β inhibitor TWS119 promotes neuronal differentiation after hypoxic-ischemic brain damage in neonatal rats. Neuroreport (IF 1.7) Pub Date : 2024-01-31 Limin Gao, Shuqiang Gao, Hailei Shan, Yanqiu Wu, Qili Zhou
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis after hypoxic-ischemic brain damage in neonatal rats remains unclear. This study investigated the effects of
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Imperatorin inhibits oxidative stress injury and neuroinflammation via the PI3K/AKT signaling pathway in the MPTP-induced Parkinson's disease mouse. Neuroreport (IF 1.7) Pub Date : 2024-01-31 Li Liu, Lei Jiang, Jinglan Zhang, Yan Ma, Min Wan, Xueqing Hu, Lian Yang
Parkinson's disease (PD) is a disorder of neurodegeneration. Imperatorin is an active natural furocoumarin characterized by antioxidant, anti-inflammatory, and potent vasodilatory properties. Therefore, we aimed to investigate the biological functions of imperatorin and its mechanisms against PD progression. C57BL/6 mice were intraperitoneally injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Effects of motion type on motion-onset and steady-state visual evoked potentials: rotation vs. flicker. Neuroreport (IF 1.7) Pub Date : 2024-01-31 BingBing Yu, Li Sui
The underlying mechanisms of information processing for two basic motion types, rotation and flicker, are not fully understood. Rotational and flickering animations at four speeds - 7 frames per second (fps), 8 fps, 11 fps, and 12 fps, respectively - are presented as visual stimuli. The motion-onset visual evoked potentials (VEPs) and steady-state VEPs (SSVEP) elicited by these motion stimuli were
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Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling. Neuroreport (IF 1.7) Pub Date : 2024-01-15 Chunnan Lin, Chunliu He, Liuqing Li, Yongqiang Liu, Liangang Tang, Zepeng Ni, Naichong Zhang, Tinghai Lai, Xiaohong Chen, Xiangyu Wang
Neuroinflammation is intimately associated with poor prognosis in patients with subarachnoid hemorrhage (SAH). Alpha-lipoic acid (ALA), a disulfide antioxidant, has been shown to be neuroprotective in an in vivo model of neurological injury; however, the role of ALA in SAH has never been evaluated. In this study, the Sprague-Dawley rats SAH model was induced by endovascular perforation method. ALA
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Histomorphological analysis of perfusion parameters and CNS lymphatic vessels in mice: an experimental method study. Neuroreport (IF 1.7) Pub Date : 2024-01-12 Xiao-Ge Liu, Qian Hua, Tian-Tian Peng, Ke-Xin Chang, Chen-Geng Deng, Jia-Ni Zhang, Xin-Yuan Yan, Chun-Xiang Wang, Ke Yan, Qing-Yuan Cai, Yan Tan
To investigate the distribution and characteristics of lymphatic vessels within the central nervous system, we focus on the meninges of the spinal cord and brain parenchyma in mice. Additionally, we aim to provide experimental methods for obtaining optimal imaging and clear structures of lymphatic vessels, while optimizing the perfusion parameters to improve histomorphological quality. Male C57BL/6J
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Hispolon inhibits neuronal ferroptosis by promoting the expression of Nrf-2. Neuroreport (IF 1.7) Pub Date : 2024-01-12 Xin Hong, Qian Deng, Chunming Zhao, Yanan Zhang, Gang Wu
Research has shown that neuronal ferroptosis is associated with various central nervous system diseases, including Parkinson's disease, acute brain injury, and spinal cord injury. Inhibiting neuronal ferroptosis can greatly alleviate the progression of these diseases. However, there is currently a lack of effective drugs to inhibit neuronal ferroptosis. In this study, we pretreated neuronal cells with
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Absence of eye position effects in the early auditory cortex of monkeys. Neuroreport (IF 1.7) Pub Date : 2024-01-09 Ying Huang, Michael Brosch
This study aims to investigate whether the position of the eyes affects the neuronal activity in auditory cortex in a condition in which not the active control of eye position but the execution of hand movements was required relative to stimuli. Two monkeys were trained to perform audio-visual tasks in which they had to use their hand to respond to both the visual and the auditory stimuli to earn a
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Altered functional connectivity between the default mode network in primary angle-closure glaucoma patients. Neuroreport (IF 1.7) Pub Date : 2024-01-09 Qiu-Yu Tang, Bing-Lin Huang, Xin Huang
Previous studies have recognized glaucoma as a neurodegenerative disease that causes extensive brain damage and is closely associated with cognitive function. In this study, we employed functional MRI to examine the intrinsic functional connectivity patterns of the default mode network (DMN) in patients diagnosed with primary angle-closure glaucoma (PACG), exploring its association with cognitive dysfunction
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Exercise alters molecular rhythms in the central nervous system that negatively correlate with depression-like behavior. Neuroreport (IF 1.7) Pub Date : 2024-01-05 Lei Yu, Haonan Xue, Zhongtang Li
Major depressive disorder (MDD) ranks among the top 10 leading causes of death. However, exercise is known to improve depressive symptoms but the mechanism responsible is still unknown. To date, numerous studies have shown that molecular rhythms and exercise are associated with MDD. Thus, we hypothesized that exercise could affect the expression of central nervous system clock genes to improve depressive
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Naringenin alleviates cognitive dysfunction in rats with cerebral ischemia/reperfusion injury through up-regulating hippocampal BDNF-TrkB signaling: involving suppression in neuroinflammation and oxidative stress. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Xiao-Qin Zhu, Dong Gao
Cognitive dysfunction is one of the common complications of cerebral ischemia-reperfusion (CI/R) injury after ischemic stroke. Neuroinflammation and oxidative stress are the core pathological mechanism of CI/R injury. The activation of brain derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling antagonize cognitive dysfunction in a series of neuropathy. Naringenin (NAR) improves
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20(S)-Ginsenoside Rh1 alleviates sevoflurane-induced ototoxicity by reducing oxidative stress levels. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Jin Lin, Li Gang, Li Wen, He Ying Zi, Shen Xia
Sevoflurane is an inhalational anesthetic widely used in pediatric surgery. However, animal studies have shown that multiple sevoflurane exposures during the neonatal period led to ototoxicity. 20(S)-Ginsenoside Rh1, a ginsenoside extract, protects against cisplatin-induced ototoxicity by scavenging free radicals.
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The influence of emotional context on emotional word processing in discourse comprehension: evidence from event-related potential. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Jingwen Li, Xue Sui, Yutong Li
This research utilized event-related potential (ERP) recording technology to examine the effect of emotional context on the processing of emotional information in sentences. Three types of emotion-consistent discourse materials (neutral-neutral, positive-positive and negative-negative) were constructed to specifically express neutral, positive and negative emotions, respectively. Each discourse comprised
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Contingency learning on the proportional congruency effect of the Stroop task is manifest in deviant processing. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Kota Suzuki
The proportion congruency effect has been reported in interference tasks. The mostly congruent block is the frequent condition, and the mostly incongruent block is the rare condition for congruent stimuli, whereas the mostly congruent block is the rare condition, and the mostly incongruent block is the frequent condition for incongruent stimuli. This study examined the cognitive mechanism underlying
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Sevoflurane anesthesia reduces the expression of inflammatory response genes and β-site amyloid precursor protein-cleaving enzyme in hippocampi of diabetic mice. Neuroreport (IF 1.7) Pub Date : 2023-12-19 Yu Xiang Han, Rui Liang, Xian Ping Yi, Xue Xia Zhang, Shao Peng Zhou
Diabetes and inhaled anesthesia are associated with an increased likelihood of developing postoperative cognitive dysfunction in humans and animal models, but the mechanisms are unclear. This study aimed to investigate the effect and mechanism of sevoflurane anesthesia on cognitive function in diabetic (DM) mice. Spontaneously diabetic db/db and control db/m mice were subject to sevoflurane anesthesia
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Sestrin2 attenuates depressive-like behaviors and neuroinflammation in CUMS mice through inhibiting ferroptosis. Neuroreport (IF 1.7) Pub Date : 2023-12-14 Xinxin Ma, Jing Wang, Qiankun Quan, Huan Zhang, Yuan Tian, Lei Wang, Ling Liu
Sestrin2 (SESN2) is a stress-inducible protein and acts as a neuroprotective regulator. The present study aimed to explore the antidepressant activity of SESN2 and its relevant mechanism. Depression mouse model was established by chronic unpredictable mild stress (CUMS) for a successive 5 weeks. Behaviors tests were conducted to examine depressive-like behaviors including sugar preference test, tail
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Reduction of acute radiation-induced brain injury in rats by anlotinib. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Yaozu Xiong, Xilei Zhou, Changhua Yu, Yusuo Tong
Radiation therapy in the treatment of brain tumors also leads to the occurrence of radiation brain injury (RBI). Anlotinib is a small-molecule inhibitor of multi-receptor tyrosine kinase with high selectivity for vascular endothelial growth factor receptor-2. In this study, we constructed a rat model of RBI and investigated the effect of anlotinib on RBI and its mechanism of action through drug intervention
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Precise sensorimotor control impacts reproductive fitness of C. elegans in 3D environments. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Hee Kyung Lee, Tong Young Lee, Jin I Lee, Kyu-Sang Park, Kyoung-Hye Yoon
The ability of animals to sense and navigate towards relevant cues in complex and elaborate habitats is paramount for their survival and reproductive success. The nematode Caenorhabditis elegans uses a simple and elegant sensorimotor program to track odors in its environments. Whether this allows the worm to effectively navigate a complex environment and increase its evolutionary success has not been
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Activation of α2A and α2B -adrenergic receptors inhibits tactile stimulation-evoked parallel fiber-Purkinje cell synaptic transmission in mouse cerebellar cortex. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Jun-Ya Wang, Yue Liu, De-Lai Qiu, Chun-Ping Chu
The mechanism by which α2-adrenergic receptors (ARs) modulate the cerebellar parallel fiber-Purkinje cell (PF-PC) synaptic transmission is unclear. We investigated this issue using electrophysiological and neuropharmacological methods. Six- to eight-week-old ICR mice were used in the study. Under in vivo conditions, PF-PC synaptic transmission was evoked by facial stimulation of ipsilateral whisker
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Intravenous administration of human chorionic membrane mesenchymal stem cells promotes functional recovery in a rat traumatic brain injury model. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Honglong Zhou, Zhaohui Yi, Dongsheng Le, Guohua Mao, Hongri Zhang
Human chorionic membrane mesenchymal stem cells (hCM-MSCs) have increasingly emerged as an excellent source of transplanted cells for regenerative therapy as they can be isolated via a non-invasive and simple method with high proliferative capabilities. However, the roles and mechanisms of hCM-MSCs on traumatic brain injury (TBI) animal models have not been investigated yet. The aim of this study was
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The mechanism of inhibition control in mathematical reasoning: a functional near-infrared spectroscopy study. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Donglin Liu, Samrah Jamshaid, Lijuan Wang
The ability to comprehend and engage in mathematical reasoning is a fundamental cognitive skill, central to problem-solving and critical thinking. However, the intricate cognitive processes underlying mathematical reasoning, particularly in relation to inhibitory control, have garnered increasing attention in recent research. While previous studies have explored this connection, there remains a need
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Acute and sub-acute metabolic change in different brain regions induced by moderate blunt traumatic brain injury. Neuroreport (IF 1.7) Pub Date : 2023-12-04 Megha Kumari, Yasha Hasija, Richa Trivedi
The objective of the study was to observe the effect of moderate closed-head injury on hippocampal, thalamic, and striatal tissue metabolism with time. Closed head injury is responsible for metabolic changes. These changes can be permanent or temporary, depending on the injury's impact. For the experiment, 20 rats were randomly divided into four groups, each containing five animals. Animals were subjected
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Employment of time-varying sensory evidence to test the mechanisms underlying flexible decision-making. Neuroreport (IF 1.7) Pub Date : 2023-12-04 Hironori Kumano, Takanori Uka
To make flexible decisions in dynamic environments, the brain must integrate behaviorally relevant information while simultaneously discarding irrelevant information. This study aimed to investigate the mechanisms responsible for discarding irrelevant information during context-dependent decision-making. We trained two macaque monkeys to switch between direction and depth discrimination tasks in successive
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The difference between induced insight by hints and induced insight by answers: an event-related potential study. Neuroreport (IF 1.7) Pub Date : 2023-11-27 Haizhou Leng, Lizhu Yang, Shuang Yang
We can solve insight problems by ourselves, by hints or by answers. This study compared the temporal features of different types of insight (spontaneous insight, induced insight by hints and induced insight by answers). Fifteen college students participated in the Chinese Remote Association Task. If they did not come up with an answer, the cue word was presented. Finally, they needed to judge whether
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In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25. Neuroreport (IF 1.7) Pub Date : 2023-11-27 Yongcang Zhang, Liang Tang, Yan Wang, Xiaoyan Zhu, Lan Liu
Byu d Mar 25 (BM25) has been verified to have neuroprotective effects in Alzheimer's disease (AD) mice. However, the molecular mechanism remains unclear. We aimed to investigate the expression profiling of lncRNAs and circRNAs by microarray analysis. Six hippocampus from LPS-mediated AD mice model treated with (normal saline (NS) (n = 3) and AD mice model treated with BM25 (n = 3) were selected. Microarray
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The severity of addiction mediates loneliness and cortical volume in internet gaming disorder. Neuroreport (IF 1.7) Pub Date : 2023-11-23 Junhong Dai, Zhen Zhao, Haohao Dong, Xiaoxia Du, Dong Guang-Heng
Internet gaming disorder (IGD) subjects reported higher loneliness scores than healthy controls. However, the neural correlates underlying the association between loneliness and IGD remain unclear. Thus, the aim of this study was to explore the relationship between loneliness, online gaming addiction and brain structure. In the current study, structural MRI data were acquired from 84 IGD subjects and
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Structure-decoupled functional connectome-based brain age prediction provides higher association to cognition. Neuroreport (IF 1.7) Pub Date : 2023-11-23 Huan Chen, Haiyan Wang, Mingxia Yu, Bin Duan
Brain age prediction as well as the prediction difference has been well examined to be a potential biomarker for brain disease or abnormal aging process. However, less knowledge was reported for the cognitive association within normal population. In this study, we proposed a novel approach to brain age prediction by structure-decoupled functional connectome. The original functional connectome was decomposed
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Amide proton transfer imaging in rats after heatstroke. Neuroreport (IF 1.7) Pub Date : 2023-11-13 Mingxing Han, Qinglong Li, Ting Yang, Jun Li
Metabolic acidosis is the most common acid-base change following heatstroke. This study aimed to evaluate the internal environment changes caused by heatstroke using amide proton transfer (APT) imaging. Nineteen male Sprague-Dawley rats were randomly divided into the control group (CTRL, n = 7) and the heatstroke group (HS, n = 12). All the rats underwent a 7.0-T MRI, which included T2-weighted imaging
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Identification and immunological characterization of cuproptosis-related molecular clusters in ischemic stroke. Neuroreport (IF 1.7) Pub Date : 2023-11-13 Chunhua Liu, Binbin Wu, Yongjun Tao, Xiang Liu, Xiqiang Lou, Zhen Wang, Zhaofu Guo, Dongmei Tang
The present study elucidated cuproptosis-related molecular clusters involved in ischemic stroke and developed predictive models. Transcriptomic and immunological profiles of ischemic stroke-related datasets were extracted from the Gene Expression Omnibus database. Next, we conducted weighted gene co-expression network analysis to determine cluster-specific differentially expressed genes (DEGs). Models
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Transplantation of Wnt3a-modified neural stem cells promotes neural regeneration and functional recovery after spinal cord injury via Wnt-Gli2 pathway. Neuroreport (IF 1.7) Pub Date : 2023-11-13 Jiezhao Lin, Yucong Lin, Shuangfang Zhu, Jinzhou Luo, Chusong Zhou
Neural stem cell (NSCs) transplantation has great potential in the treatment of spinal cord injury (SCI). Previous studies have indicated that the Wnt pathway could regulate the expression of basic helix-loop-helix (bHLH) family factor Hes5 and Mash1 in NSCs, but not through the notch intracellular domain. This suggests that there are other signals involved in this process. The aim of this study was
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Altered cognitive control network mediates the association between long-term pain and anxiety symptoms in primary dysmenorrhea. Neuroreport (IF 1.7) Pub Date : 2023-11-13 Zheng Yu, Han Yang, Li-Ying Liu, Lin Chen, Meng-Hua Su, Lu Yang, Man-Jia Zhu, Li-Li Yang, Fanrong Liang, Siyi Yu, Jie Yang
Neuroimaging studies have demonstrated the association of the cognitive control network (CCN) with the maintenance of chronic pain. However, whether and how dorsolateral prefrontal cortex (DLPFC), a key region within the CCN, is altered in menstrual pain is unclear. In this study, we aimed to investigate alterations in the DLPFC functional connectivity network in patients with primary dysmenorrhea
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Acupuncture with specific mode electro-stimulation effectively and transiently opens the BBB through Shh signaling pathway. Neuroreport (IF 1.7) Pub Date : 2023-11-08 Yubo Lin, Lin Gan, Li Ren, Congcong Ma, Mengyuan Dai, Kecheng Qian, Qinyu Ye, Xianming Lin
To explore a new method that patients with brain diseases such as stroke sequelae are hindered by blood-brain barrier (BBB) in clinical treatment. Research preliminarily found that acupuncture with specific mode electro-stimulation (EA) to open BBB-assisted drug delivery may be is an effective means to improve the clinical efficacy of brain disease patients. So here we further explore the features
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Magnetic cortical oscillations associated with subjective auditory coolness during paired comparison of time-varying HVAC sounds. Neuroreport (IF 1.7) Pub Date : 2023-10-30 Hajime Yano, Tetsuya Takiguchi, Seiji Nakagawa
The impressions of heating, ventilation, and air conditioning (HVAC) sounds are important for the comfort people experience in their living spaces. Revealing neural substrates of the impressions induced by HVAC sounds can help to develop neurophysiological indices of the comfort of HVAC sounds. There have been numerous studies on the brain activities associated with the pleasantness of sounds, but
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Exploratory analysis of cortical thickness in low- and high-fit young adults. Neuroreport (IF 1.7) Pub Date : 2023-10-30 Yi Ran Wang, Arnaud Boré, Jonathan Tremblay, Maxime Descoteaux, François Champoux, Hugo Théoret
Studies have shown changes in the human brain associated with physical activity and cardiorespiratory fitness (CRF). The effects of CRF on cortical thickness have been well-described in older adults, where a positive association between CRF and cortical thickness has been reported, but the impact of sustained aerobic activity in young adults remains poorly described. Here, exploratory analysis was
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Abnormal functional connectivity strength in age-related macular degeneration patients: a fMRI study. Neuroreport (IF 1.7) Pub Date : 2023-10-27 Yue-Hong Cai, Xin Huang
Age-related macular degeneration (AMD) is a serious blinding eye disease. Previous neuroimaging studies reported that AMD were accompanied by abnormalities of the brain. However, whether AMD patients were associated with functional connectivity strength (FCS) or not remains unknown. In our study, the purpose of the study was to assess FCS changes in AMD patients.
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μ opioid receptor carboxyl terminal-derived peptide alleviates morphine tolerance by inhibiting β-arrestin2. Neuroreport (IF 1.7) Pub Date : 2023-10-27 Meng Zhang, Yanling Zhang, Jian Li, Junliang Li, Junwei Ji, Zhongshan Wang
The interaction between the μ opioid receptor (MOR) and β-arrestin2 serves as a model for addressing morphine tolerance. A peptide was designed to alleviate morphine tolerance through interfering with the interaction of MOR and β-arrestin2. We developed a peptide derived from MOR. The MOR-TAT-pep peptide was expressed in E. coli Bl21(DE3) and purified. The effects of MOR-TAT-pep in alleviating morphine
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Macrophages are scavengers for injured myelin in a rabbit model of acute inflammatory demyelinating polyneuropathy. Neuroreport (IF 1.7) Pub Date : 2023-10-27 Jie Xu, Nobuhiro Yuki, Norito Kokubun, Feng Gao, Fangzhen Shan, Qiguang Shi, Yuzhong Wang
In acute inflammatory demyelinating polyneuropathy (AIDP), myelin vesiculation mediated by complement activation contributes to nerve injury. Macrophage infiltration of the spinal roots has been demonstrated in AIDP, but its pathological significance remains uncertain. The present study aimed to investigate the role of macrophages in the pathogenic sequence of AIDP. A rabbit model of AIDP was induced
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Inhibition of the TLR4/NF-κB pathway promotes the polarization of LPS-induced BV2 microglia toward the M2 phenotype. Neuroreport (IF 1.7) Pub Date : 2023-10-18 Jiehong Xie, Peng Tuo, Wei Zhang, Shouping Wang
This study aimed to investigate whether the inhibition of the TLR4/NF-κB pathway can promote lipopolysaccharide (LPS)-induced microglial polarization from the M1 to M2 phenotype, and thus exert neuroprotection. LPS-induced microglia were used as a model for inflammation in vitro. TLR4-specific inhibitor resatorvid (TAK-242) and NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) were used to verify
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Recombinant human erythropoietin protects against immature brain damage induced by hypoxic/ischemia insult. Neuroreport (IF 1.7) Pub Date : 2023-10-18 Zhengda Sun, Jiqing Song, Qijun Song, Lin Li, Xinxin Tian, Lijun Wang
To investigate the neuroprotection of recombinant human erythropoietin (rhEPO) against hypoxic/ischemic (HI) insult in three-day-old rats. Postnatal day 3 (PD3) rats were randomly divided into three groups: Sham group, HI group and HI+rhEPO group. Ligation of the right common carotid artery and hypoxia to induce HI brain injury. After HI insult, the rats received intraperitoneal injection of rhEPO
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Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an Aβ1-42-induced Alzheimer's disease rat model by activating BDNF/TrkB signaling transduction. Neuroreport (IF 1.7) Pub Date : 2023-10-18 Zhirong Gu, Xin Lv, Yan Guo, Mei Qi, Bin Ge
Alzheimer's disease (AD) is a degenerative disorder characterized by cognitive dysfunction and BDNF/TrkB is a well-conceived anti-AD signaling. Cynomorium songaricum Rupr. (C. songaricum) is a herb with promising neuroprotective effects and the function is majorly attributed to flavonoids. The current study attempted to explore the effects of total flavonoids of C. songaricum (CS) on AD model by focusing
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Neurophysiological effects of frequency, length, phonological neighborhood density, and iconicity on sign recognition. Neuroreport (IF 1.7) Pub Date : 2023-10-12 Xiaohong Zhang, Hongwen Cao, Hong Li
Current theories on lexical recognition are mostly based on studies from spoken languages or their written forms. Much less is known about the process of lexical recognition in sign languages. This study aims to examine the neural correlates of sign recognition by investigating the effects of lexical frequency, length, phonological neighborhood density, and iconicity during Chinese Sign Language comprehension
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Effects of virtual reality working memory task difficulty on the passive processing of irrelevant auditory stimuli. Neuroreport (IF 1.7) Pub Date : 2023-10-06 Farooq Kamal, Melanie Segado, Vincent Gagnon Shaigetz, Maxime Perron, Brian Lau, Claude Alain, Nusrat Choudhury
The virtual reality (VR) environment is claimed to be highly immersive. Participants may thus be potentially unaware of their real, external world. The present study presented irrelevant auditory stimuli while participants were engaged in an easy or difficult visual working memory (WM) task within the VR environment. The difficult WM task should be immersive and require many cognitive resources, thus
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Healthy and pathological pallidal regulation of thalamic burst versus tonic mode firing: a computational simulation. Neuroreport (IF 1.7) Pub Date : 2023-09-20 Deepak Kumbhare, Md Ali Azam, Ravi Hadimani, Jamie Toms, George Weistroffer, Jayasimha Atulasimha, Mark S Baron
The mechanisms by which the basal ganglia influence the pallidal-receiving thalamus remain to be adequately defined. Our prior in vivo recordings in fully alert normal and dystonic rats revealed that normally fast tonic discharging entopeduncular [EP, rodent equivalent of the globus pallidus internus (GPi)] neurons are pathologically slow, highly irregular, and bursty under dystonic conditions. This
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Disrupted functional connectivity of the striatum in patients with diffuse axonal injury: a resting-state functional MRI study. Neuroreport (IF 1.7) Pub Date : 2023-09-20 Zhigang Xu, Ye Li, Xiaole Fan, Wenhua Xu, Jinliang Liu, Jian Li
Diffuse axonal injury (DAI) disrupts the integrity of white matter microstructure and affects brain functional connectivity, resulting in persistent cognitive, behavioral and affective deficits. Mounting evidence suggests that altered cortical-subcortical connectivity is a major contributor to cognitive dysfunction. The functional integrity of the striatum is particularly vulnerable to DAI, but has
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Prenatal Zika virus exposure is associated with lateral geniculate nucleus abnormalities in juvenile rhesus macaques. Neuroreport (IF 1.7) Pub Date : 2023-09-11 Erin E Ball, Jeffrey L Bennett, Rebekah I Keesler, Koen K A Van Rompay, Lark L Coffey, Eliza Bliss-Moreau
Zika virus' neural tropism causes significant neural pathology, particularly in developing fetuses. One of the consistent findings from humans and animal models is that prenatal exposure to Zika virus (ZIKV) causes pathology in the eyes and visual pathways of the brain, although the extent to which this pathology persists over development is not clear. In the present report, we build upon our previous
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Recursive structures modulate the electrophysiological correlates of visual perspective taking. Neuroreport (IF 1.7) Pub Date : 2023-09-11 Feng Xiao, Feng-Qi He, Yu-Huan Zhong, Jie Deng, Chao Zhang
An increasing number of studies have focused on the neural basis of complex mental inferences, which requires an understanding of the recursive nature of thought; however, the precise electrophysiological response to a recursive structure remains unclear. The present event-related potential (ERP) study investigated the recursive structure effect on the neural correlates of visual perspective taking
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Activation of autophagy after blast-induced traumatic brain injury in mice. Neuroreport (IF 1.7) Pub Date : 2023-08-30 Yuan Zhou, Yue Song, Lin Zhu
Injury mechanism and treatment of blast-induced traumatic brain injury (bTBI) has not made a breakthrough so far. Previous reports demonstrate autophagy is involved in regulating the pathophysiological process after TBI. Therefore, this study explored whether autophagy was activated after bTBI. A total of 108 mice were divided randomly into six groups: 6 h, 1 d, 3 d, 7 d, 14 d after bTBI groups and
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Plasma MMP-9/TIMP-1 ratio serves as a novel potential biomarker in Alzheimer's disease. Neuroreport (IF 1.7) Pub Date : 2023-08-30 Jingfeng Liu, Xing Li, Ji Qu
This study aimed to explore the diagnostic potential of plasma MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for Alzheimer's disease (AD). This retrospective study was performed in a cohort consisting of patients with AD (AD group) and cognitive normal subjects (HC group). Cerebrospinal fluid (CSF) classic biomarkers including Aβ42, Aβ40, total tau (t-tau), and phosphorylated tau (p-tau) levels, and plasma
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Curcumin protects from LPS-induced activation of astrocytes via AMPK pathway. Neuroreport (IF 1.7) Pub Date : 2023-08-30 Jing Cheng, Yu Zhou, Haowen Qiao, Hongxiang Jiang, Yanqin Fan
Curcumin, a phenolic pigment, plays an inhibitory role in astrocytes activation which are involved in the pathogenesis of neurological diseases and inflammatory responses. The present study aimed to investigate the underlying regulatory mechanism behind the therapeutic effect of curcumin on the lipopolysaccharide (LPS)-activated astrocytes in vitro. Specifically, we investigated the inhibitory effect