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The Alterations in the Brain Corresponding to Low Back Pain: Recent Insights and Advances Neural Plast. (IF 3.1) Pub Date : 2024-3-18 Xuyang Li, Fancheng Meng, Wenye Huang, Yue Cui, Fanbo Meng, Shengxi Wu, Hui Xu
Low back pain (LBP) is a leading cause of global disabilities. Numerous molecular, cellular, and anatomical factors are implicated in LBP. Current issues regarding neurologic alterations in LBP have focused on the reorganization of peripheral nerve and spinal cord, but neural mechanisms of exactly what LBP impacts on the brain required further researches. Based on existing clinical studies that chronic
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Electroacupuncture Therapy Effectively Protects the Rat Brain after Intracerebral Hemorrhage Neural Plast. (IF 3.1) Pub Date : 2024-2-15 Li Huang, Xuehui Fan, Yao Chen, Heng Lin, Xiaoqian Jiang, Chaoxian Yang
Objective. Electroacupuncture (Ea) is a useful complementary and alternative therapy for intracerebral hemorrhage (ICH). However, the neurobiological basis for the Ea treatment of ICH is still unclear. The primary aim of the present study was to explore whether Ea prevents brain edema, apoptosis, excitotoxicity, and neuroinflammation in rats after hemorrhagic stroke. Methods. Rats were randomly divided
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Chronic Ultrasound Prenatal Stress Altered the Brain’s Neurochemical Systems in Newborn Rats Neural Plast. (IF 3.1) Pub Date : 2024-2-13 Olga Abramova, Yana Zorkina, Konstantin Pavlov, Valeria Ushakova, Anna Morozova, Eugene Zubkov, Olga Pavlova, Zinaida Storozheva, Olga Gurina, Vladimir Chekhonin
Prenatal stress (PS) affects the development and functioning of the central nervous system, but the exact mechanisms underpinning this effect have not been pinpointed yet. A promising model of PS is one based on chronic exposure of pregnant rodents to variable-frequency ultrasound (US PS), as it mimics the PS with a psychic nature that most adequately captures the human stressors in modern society
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A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive–Compulsive Disorder Neural Plast. (IF 3.1) Pub Date : 2023-12-7 Jin Jiang, Ke Wan, Yueling Liu, Yan Tang, Wenxin Tang, Jian Liu, Jiehua Ma, Chuang Xue, Lu Chen, Huichang Qian, Dandan Liu, Xinxin Shen, Ruijuan Fan, Yongguang Wang, Kai Wang, Gongjun Ji, Chunyan Zhu
Background. Obsessive–compulsive disorder (OCD) is frequently treated using a combination of counseling, drugs, and, more recently various transcranial stimulation protocols, but all require several weeks to months for clinically significant improvement, so there is a need for treatments with faster onset. This study investigated whether an accelerated high-dose theta burst stimulation (ahTBS) protocol
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Premotor and Posterior Parietal Cortex Activity is Increased for Slow, as well as Fast Walking Poststroke: An fNIRS Study Neural Plast. (IF 3.1) Pub Date : 2023-10-13 Shannon B. Lim, Sue Peters, Chieh-ling Yang, Lara A. Boyd, Teresa Liu-Ambrose, Janice J. Eng
Background and Purpose. The ability to change gait speeds is important for interacting with the surrounding environment. Gait speed modulation poststroke is often impaired and is related to decreased walking independence after stroke. Assessment of brain activation during walking at different speeds can provide insight into important regions for facilitating gait recovery. The purpose is to determine:
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Clinical Research Progress of the Post-Stroke Upper Limb Motor Function Improvement via Transcutaneous Auricular Vagus Nerve Stimulation Neural Plast. (IF 3.1) Pub Date : 2023-9-25 Xiaolong Shi, Jingjun Zhao, Shutian Xu, Meng Ren, Yuwei Wu, Xixi Chen, Zhiqing Zhou, Songmei Chen, Yu Huang, Yuanli Li, Chunlei Shan
Stroke is a disease with high morbidity and disability, and motor impairment is a common sequela of stroke. Transcutaneous auricular vagus nerve stimulation (taVNS) is a type of non-invasive stimulation, which can effectively improve post-stroke motor dysfunction. This review discusses stimulation parameters, intervention timing, and the development of innovative devices for taVNS. We further summarize
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Vasoprotective Effects of Hyperoside against Cerebral Ischemia/Reperfusion Injury in Rats: Activation of Large-Conductance Ca2+-Activated K+ Channels Neural Plast. (IF 3.1) Pub Date : 2023-8-14 Wen-Ming Hong, Yue-Wu Xie, Meng-Yu Zhao, Tian-Hang Yu, Li-Na Wang, Wan-Yan Xu, Shen Gao, Hua-Bao Cai, Yan Guo, Fang Zhang
Hyperoside (Hyp), a kind of Chinese herbal medicine, exerts multiple therapeutic effects on many diseases. However, the role and mechanisms of Hyp in vascular pathophysiology in ischemic stroke need to be further established. The study aimed to investigate the role of (large-conductance Ca2+-activated K+) BK channels on the vasoprotection of Hyp against cerebral ischemia and reperfusion (I/R) injury
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White Matter Microstructural Alterations over the Year after Acute Ischemic Stroke in Patients with Baseline Impaired Cognitive Functions Neural Plast. (IF 3.1) Pub Date : 2023-7-7 Bingyuan Wu, Shida Guo, Xiuqin Jia, Zuojun Geng, Qi Yang
Background. The disruption of white matter (WM) integrity is related to poststroke cognitive impairment (PSCI). The exploration of WM integrity alterations in the chronic stage of acute ischemic stroke (AIS) may help to improve the long-term outcomes of PSCI. Methods. Sixty patients showing impaired cognitive functions within 3 days after AIS (baseline) and 25 healthy controls underwent diffusion kurtosis
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Acupuncture Alters Brain’s Dynamic Functional Network Connectivity in Stroke Patients with Motor Dysfunction: A Randomised Controlled Neuroimaging Trial Neural Plast. (IF 3.1) Pub Date : 2023-6-20 Yahui Wang, Mengxin Lu, Ruoyi Liu, Liping Wang, Yue Wang, Lingling Xu, Kang Wu, Chen Chen, Tianzhu Chen, Xinyue Shi, Kuangshi Li, Yihuai Zou
Objectives. Neuroimaging studies have confirmed that acupuncture can promote static functional reorganization in poststroke patients with motor dysfunction. But its effect on dynamic brain networks remains unclear. This study is aimed at investigating how acupuncture affected the brain’s dynamic functional network connectivity (dFNC) after ischemic stroke. Methods. We conducted a single-center, randomised
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Effect of Cathodal Transcranial Direct Current Stimulation for Lower Limb Subacute Stroke Rehabilitation Neural Plast. (IF 3.1) Pub Date : 2023-5-27 Qian Duan, Wenying Liu, Jinhui Yang, Ben Huang, Jie Shen
Background and Purpose. Motor dysfunction of the lower limb is a common sequela in stroke patients. The aim was to evaluate the efficacy of cathodal transcranial direct current stimulation (ctDCS) combined with conventional gait rehabilitation (CGR) to compare and clarify the clinical rehabilitation efficacy of ctDCS on motor dysfunction of the lower limbs after stroke to improve the walking ability
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Intrinsic Brain Functional Activity Abnormalities in Episodic Tension-Type Headache Neural Plast. (IF 3.1) Pub Date : 2023-5-24 Xiu Yang, DianXuan Guo, Wei Huang, Bing Chen
Objective. The neurobiological basis of episodic tension-type headache (ETTH) remains largely unclear. The aim of the present study was to explore intrinsic brain functional activity alterations in ETTH. Methods. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 32 patients with ETTH and 32 age- and gender-matched healthy controls (HCs). Differences in intrinsic
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Imbalance of Microbacterial Diversity Is Associated with Functional Prognosis of Stroke Neural Plast. (IF 3.1) Pub Date : 2023-5-8 Xintong Zhang, Xiangyu Wang, Hong Zhao, Risheng Cao, Yini Dang, Binbin Yu
Objectives. There is mounting evidence to suggest that the pathophysiology of stroke is greatly influenced by the microbiota of the gut and its metabolites, in particular short-chain fatty acids (SCFAs). The primary purpose of the study was to evaluate whether the levels of SCFAs and the gut microbiota are altered in poststroke patients and to examine the relationship between these alterations and
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Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity Neural Plast. (IF 3.1) Pub Date : 2023-5-2 Peng Li, Wenya Huang, Yiping Chen, Muhammad Shahzad Aslam, Wenjing Cheng, Yang Huang, Wenjie Chen, Yanxun Huang, Xinnan Wu, Yining Yan, Junliang Shen, Tao Tong, Shuqiong Huang, Xianjun Meng
Purpose. To explore the therapeutic efficiency of acupuncture and the related molecular mechanism of neural plasticity in depression. Methods. Chronic unpredictable mild stress- (CUMS-) induced rats were established for the depression animal model. There were a total of four rat groups, including the control group, the CUMS group, the CUMS+acupuncture group, and the CUMS+fluoxetine group. The acupuncture
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Olfactory Loss and Brain Connectivity after COVID-19: Structural Follow-Up at One Year Neural Plast. (IF 3.1) Pub Date : 2023-4-29 Fabrizio Esposito, Mario Cirillo, Rosa De Micco, Giuseppina Caiazzo, Mattia Siciliano, Andrea G. Russo, Caterina Monari, Nicola Coppola, Gioacchino Tedeschi, Alessandro Tessitore
The structural connectivity from the primary olfactory cortex to the main secondary olfactory areas was previously reported as relatively increased in the medial orbitofrontal cortex in a cohort of 27 recently SARS-CoV-2-infected (COV+) subjects, of which 23/27 had clinically confirmed olfactory loss, compared to 18 control (COV-) normosmic subjects, who were not previously infected. To complement
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The Effect of Swallowing Action Observation Therapy on Resting fMRI in Stroke Patients with Dysphagia Neural Plast. (IF 3.1) Pub Date : 2023-4-21 Ming Zeng, Zhongli Wang, Xuting Chen, Meifang Shi, Meihong Zhu, Jingmei Ma, Yunhai Yao, Yao Cui, Hua Wu, Jie Shen, Lingfu Xie, Jianming Fu, Xudong Gu
Objective. Many stroke victims have severe swallowing problems. Previous neuroimaging studies have found that several brain regions scattered in the frontal, temporal, and parietal lobes, such as Brodmann’s areas (BA) 6, 21, and 40, are associated with swallowing function. This study sought to investigate changes in swallowing function and resting-state functional magnetic resonance imaging (rs-fMRI)
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Effect of Hypoxia-Ischemia on the Expression of Iron-Related Proteins in Neonatal Rat Brains Neural Plast. (IF 3.1) Pub Date : 2023-4-20 Qing Lin, Ding-Wang Hu, Xin-Hui Hao, Geng Zhang, Ling Lin
Hypoxic-ischemic white matter injury (WMI) pathogenesis in preterm infants is not well established, and iron-related proteins in the brain may play an important role in imbalanced iron metabolism. We aimed to investigate the iron-related protein changes in neonatal rats after hypoxia-ischemia (HI), clarify the role of iron-related proteins in hypoxic-ischemic WMI, and potentially provide a new target
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Electroencephalogram-Based Brain Connectivity Analysis in Prolonged Disorders of Consciousness Neural Plast. (IF 3.1) Pub Date : 2023-4-18 Yuzhang Wu, Zhitao Li, Ruowei Qu, Yangang Wang, Zhongzhen Li, Le Wang, Guangrui Zhao, Keke Feng, Yifeng Cheng, Shaoya Yin
Background. Prolonged disorders of consciousness (pDOC) are common in neurology and place a heavy burden on families and society. This study is aimed at investigating the characteristics of brain connectivity in patients with pDOC based on quantitative EEG (qEEG) and extending a new direction for the evaluation of pDOC. Methods. Participants were divided into a control group (CG) and a DOC group by
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Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy Neural Plast. (IF 3.1) Pub Date : 2023-4-17 Yajin Huang, Yaqing Liu, Wenjun Song, Yanjun Liu, Xiaoqian Wang, Juping Han, Jiang Ye, Hongmei Han, Li Wang, Juan Li, Tiancheng Wang
Objective. Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy. Methods. Participants underwent one-night sleep electroencephalogram recording and neuropsychological tests on the same day. Spindle
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The Effect of Motor Imaginary Combined with Transcranial Direct Current Stimulation (tDCS) on Balance in Middle-Aged Women with High Fall Risk: A Double-Blind Randomized Controlled Trial Neural Plast. (IF 3.1) Pub Date : 2023-3-31 Esmaeil Mozafaripour, Seyed Kazem Mousavi Sadati, Leila Najafi, Maryam Zoghi
Introduction. The risk of falling and its subsequent injuries increases with aging. Impaired balance and gait are important contributing factors to the increased risk of falling. A wide range of methods was examined to improve balance, but these interventions might produce small effects or be inapplicable for this population. The current study aimed at investigating the effect of motor imaginary (MI)
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Alterations in Human Hippocampus Subregions across the Lifespan: Reflections on White Matter Structure and Functional Connectivity Neural Plast. (IF 3.1) Pub Date : 2023-3-28 Jianling Tan, Zhongyan Wang, Yi Tang, Yin Tian
During growth and aging, the role of the hippocampus in memory depends on its interactions with related brain regions. Particularly, two subregions, anterior hippocampus (aHipp) and posterior hippocampus (pHipp), play different and critical roles in memory processing. However, age-related changes of hippocampus subregions on structure and function are still unclear. Here, we investigated age-related
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Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System Neural Plast. (IF 3.1) Pub Date : 2023-3-22 Yuji Tsuchikawa, Naosuke Kamei, Yohei Sanada, Toshio Nakamae, Takahiro Harada, Kazunori Imaizumi, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi
Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary functions, the role of these miRNA clusters in myelination has not been studied. To investigate the role of miR-23-27-24 clusters in myelination, we
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Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice Neural Plast. (IF 3.1) Pub Date : 2023-3-21 Wei Wei, Zhicheng Lin, PeiTao Xu, Xinru Lv, Libin Lin, Yongxu Li, Yangjie Zhou, Taotao Lu, Xiehua Xue
High-fat diet- (HFD-) induced neuroinflammation may ultimately lead to an increased risk of cognitive impairment. Here, we evaluate the effects of diet control and swimming or both on the prevention of cognitive impairment by enhancing SIRT1 activity. Twenty-week-old ApoE-/- mice were fed a HFD for 8 weeks and then were treated with diet control and/or swimming for 8 weeks. Cognitive function was assessed
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Evidence Mapping Based on Systematic Reviews of Cognitive Behavioral Therapy for Neuropathic Pain Neural Plast. (IF 3.1) Pub Date : 2023-3-18 Conghui Li, Weiqian Hou, Dongfang Ding, Yujie Yang, Shanshan Gu, Yi Zhu
Objective. This evidence mapping is aimed at identifying, summarizing, and analyzing the available evidence on cognitive behavioral therapy (CBT) for neuropathic pain (NP). Methods. This study was conducted following the methodology of Global Evidence Mapping (GEM). Searches were conducted in PubMed, Embase, the Cochrane Library, and PsycINFO to identify systematic reviews (SRs) with or without meta-analysis
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Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation Neural Plast. (IF 3.1) Pub Date : 2023-3-2 Yi-li Wang, Hai-yan Zhu, Xi-qian Lv, Xing-ying Ren, Ying-chun Peng, Jin-yu Qu, Xue-fang Shen, Ran Sun, Meng-lu Xiao, Hong Zhang, Zhao-hui Chen, Peng Cong
Referred somatic pain triggered by hyperalgesia is common in patients with inflammatory bowel disease (IBD). It was reported that sprouting of sympathetic nerve fibers into the dorsal root ganglion (DGR) and neurogenic inflammation were related to neuropathic pain, the excitability of neurons, and afferents. The purpose of the study was to explore the potential and mechanism of electroacupuncture (EA)
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From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review Neural Plast. (IF 3.1) Pub Date : 2023-2-28 Anca Badoiu, Smaranda Ioana Mitran, Bogdan Catalin, Tudor Adrian Balseanu, Aurel Popa-Wagner, Florin Liviu Gherghina, Carmen Valeria Albu, Raluca Elena Sandu
Stroke is a major health problem worldwide, with numerous health, social, and economic implications for survivors and their families. One simple answer to this problem would be to ensure the best rehabilitation with full social reintegration. As such, a plethora of rehabilitation programs was developed and used by healthcare professionals. Among them, modern techniques such as transcranial magnetic
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Functional Connectivity Changes in the Insular Subregions of Patients with Obstructive Sleep Apnea after 6 Months of Continuous Positive Airway Pressure Treatment Neural Plast. (IF 3.1) Pub Date : 2023-2-21 Ting Long, Haijun Li, Yongqiang Shu, Kunyao Li, Wei Xie, Yaping Zeng, Ling Huang, Li Zeng, Xiang Liu, Dechang Peng
This study was aimed at investigating the functional connectivity (FC) changes between the insular subregions and whole brain in patients with obstructive sleep apnea (OSA) after 6 months of continuous positive airway pressure (CPAP) treatment and at exploring the relationship between resting-state FC changes and cognitive impairment in OSA patients. Data from 15 patients with OSA before and after
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Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex Neural Plast. (IF 3.1) Pub Date : 2023-2-15 Amielle Moreno, Swetha Rajagopalan, Matthew J. Tucker, Parker Lunsford, Robert C. Liu
While infant cues are often assumed to innately motivate maternal response, recent research highlights how the neural coding of infant cues is altered through maternal care. Infant vocalizations are important social signals for caregivers, and evidence from mice suggests that experience caring for mouse pups induces inhibitory plasticity in the auditory cortex (AC), though the molecular mediators for
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Leonurine Regulates Hippocampal Nerve Regeneration in Rats with Chronic and Unpredictable Mild Stress by Activating SHH/GLI Signaling Pathway and Restoring Gut Microbiota and Microbial Metabolic Homeostasis Neural Plast. (IF 3.1) Pub Date : 2023-1-7 Pan Meng, Xi Zhang, Dandan Li, Hui Yang, Xiaoyuan Lin, Hongqing Zhao, Ping Li, Yuhong Wang, Xiaoye Wang, Jinwen Ge
Depression is a highly prevalent and heterogeneous disorder that requires new strategies to overcome depression. In this study, we aimed to investigate whether leonurine modulated hippocampal nerve regeneration in chronic and unpredictable mild stress (CUMS) rats through the SHH/GLI signaling pathway and restoring gut microbiota and microbial metabolic homeostasis. The CUMS rat model was constructed
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Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease Neural Plast. (IF 3.1) Pub Date : 2023-1-4 N. P. Camacho-Hernández, F. Peña-Ortega
CX3CR1 is a G protein-coupled receptor that is expressed exclusively by microglia within the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine fractalkine (FKN), which is constitutively expressed in neuronal cell membranes and tonically released by them. Through its key role in microglia-neuron communication, the FKN/CX3CR1 axis regulates microglial state, neuronal survival
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Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial Neural Plast. (IF 3.1) Pub Date : 2022-12-31 Xin Wen, Li Li, Xuelian Li, Huanghong Zha, Zicai Liu, Yang Peng, Xuejin Liu, Huiyu Liu, Quan Yang, Jing Wang
Background. Rehabilitation of upper extremity hemiplegia after stroke remains a great clinical challenge, with only 20% of patients achieving a basic return to normal hand function. How to promote the recovery of motor function at an early stage is crucial to the life of the patient. Objectives. To invest the effects of additional mirror therapy in improving upper limb motor function and activities
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Ulinastatin Alleviates Repetitive Ketamine Exposure-Evoked Cognitive Impairment in Adolescent Mice Neural Plast. (IF 3.1) Pub Date : 2022-12-12 Yu Hong, Shiyu Meng, Shouping Wang, Ting Liu, Jiayi Liu
Ketamine (KET) is widely used for induction and maintenance of anesthesia, and long-term use is required for treatment of depression patients. Repeated use of KET is associated with mood and memory disorders. Ulinastatin (UTI), a urinary trypsin inhibitor, has been widely undertaken as an anti-inflammatory drug and proved to have neuroprotective effects. The aim of this work was to determine whether
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Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway Neural Plast. (IF 3.1) Pub Date : 2022-12-3 Yan Meng, Shengxue Yu, Fang Zhao, Yu Liu, Yue Wang, Siqi Fan, Yuhong Su, Meili Lu, Hongxin Wang
Long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. Astragaloside IV (AS-IV) is widely used in the antiapoptotic therapy of brain injury diseases. However, its mechanism of action is still not fully understood. In this study, we investigated the effect of AS-IV on hypoxia-induced oxidative stress and apoptosis in hippocampal neurons
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Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN Neural Plast. (IF 3.1) Pub Date : 2022-11-21 Lin Shi, Katie Palmer, Haolin Wang, Matthew A. Xu-Friedman, Wei Sun
Sound stimulation is generally used for tinnitus and hyperacusis treatment. Recent studies found that long-term noise exposure can change synaptic and firing properties in the central auditory system, which will be detected by the acoustic startle reflex. However, the perceptual consequences of long-term low-intensity sound exposure are indistinct. This study will detect the effects of moderate-level
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Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack Neural Plast. (IF 3.1) Pub Date : 2022-11-18 Zeqi Hao, Yulin Song, Yuyu Shi, Hongyu Xi, Hongqiang Zhang, Mengqi Zhao, Jiahao Yu, Lina Huang, Huayun Li
Objective. This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA). Methods. A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants were scanned using MRI, and their clinical characteristics were collected. To investigate motor-related
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Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness Neural Plast. (IF 3.1) Pub Date : 2022-11-16 Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni
Objective. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has been proposed as a promising therapeutic intervention for patients with disorders of consciousness (DOC). However, its therapeutic effects in the literature are inconsistently documented. The primary aim of this study was to explore the alterations in neural connectivity and neurobehavioral reactivity during rTMS modulation
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Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42 Neural Plast. (IF 3.1) Pub Date : 2022-11-10 Shan Li, Guo-Ji Yan, Ya-Xin Tan, Lu-Lu Xue, Ting-Hua Wang, Hao-Ran Zhao, Min-Nan Lu, Hui-Xiang Zhang, Rong Mei, Xiao-Han Dong, Li-Na Liu, Dan Wang, Yan-Bin Xiyang
Voltage-gated sodium channel beta 2 (Nav2.2 or Navβ2, coded by SCN2B mRNA), a gene involved in maintaining normal physiological functions of the prefrontal cortex and hippocampus, might be associated with prefrontal cortex aging and memory decline. This study investigated the effects of Navβ2 in amyloid-β 1-42- (Aβ1-42-) induced neural injury model and the potential underlying molecular mechanism.
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Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential Neural Plast. (IF 3.1) Pub Date : 2022-11-8 John Olichney, Jiangyi Xia, Kevin J. Church, Hans J. Moebius
Neurodegenerative diseases, such as Alzheimer’s disease (AD), and their associated deterioration of cognitive function are common causes of disability. The slowly developing pathology of neurodegenerative diseases necessitates early diagnosis and monitored long-term treatment. Lack of effective therapies coupled with an improved rate of early diagnosis in our aging population have created an urgent
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Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice Neural Plast. (IF 3.1) Pub Date : 2022-10-19 Xinzheng Sun, Chenghao Wang, Junqi Wu, Xiaoke Chen, Hui He
Peripheral nerve injury leads to severe neuropathic pain. Previous studies have highlighted the beneficial effects of physical exercise on alleviating neuropathic pain. Exercise regulating transforming growth factor-β1 (TGF-β1) can improve several diseases and relieve neuropathic pain induced by peripheral nerve injury. Here, we investigated whether exercise could alleviate neuropathic pain by modulating
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Self-Directed Neurofeedback Treatment for Subjective Tinnitus Patients Evaluated by Multimodal Functional Imaging Neural Plast. (IF 3.1) Pub Date : 2022-10-18 Xiaoyan Ma, Fangyuan Wang, Chi Zhang, Weidong Shen, Shiming Yang
Neurofeedback (NFB) is a relatively novel approach to the treatment of tinnitus, and prior studies have demonstrated that the increases in alpha activity rather than reduced delta power seem to drive these NFB-related improvements in tinnitus symptoms. The present study was therefore designed to explore whether the implementation of an alpha training protocol with a portable neurofeedback apparatus
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The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach Neural Plast. (IF 3.1) Pub Date : 2022-10-17 Huibin Ma, Zhou Xie, Lina Huang, Yanyan Gao, Linlin Zhan, Su Hu, Jiaxi Zhang, Qingguo Ding
Background. Transient ischemic attack (TIA) is a known risk factor for stroke. Abnormal alterations in the low-frequency range of the gray matter (GM) of the brain have been studied in patients with TIA. However, whether there are abnormal neural activities in the low-frequency range of the white matter (WM) in patients with TIA remains unknown. The current study applied two resting-state metrics to
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Inhibition of Cerebral Ischemia/Reperfusion Injury by MSCs-Derived Small Extracellular Vesicles in Rodent Models: A Systematic Review and Meta-Analysis Neural Plast. (IF 3.1) Pub Date : 2022-10-6 Lei Zhang, Chaoying Pei, Dan Hou, Guoshuai Yang, Dan Yu
Small extracellular vesicles (sEVs) secreted by mesenchymal stem cells (MSCs) have shown great therapeutic potential in cerebral ischemia-reperfusion injury (CIRI). In this study, we firstly performed a systematic review to evaluate the efficacy of MSCs-derived sEV for experimental cerebral ischemia/reperfusion injury. 24 studies were identified by searching 8 databases from January 2012 to August
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Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome Neural Plast. (IF 3.1) Pub Date : 2022-10-4 Jiandong Sun, Yan Liu, Xiaoning Hao, Michel Baudry, Xiaoning Bi
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, which is both an E3 ligase and a cofactor for transcriptional regulation. We previously showed that the small conductance potassium channel protein SK2 is a UBE3A substrate
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Progression in Time of Dentate Gyrus Granule Cell Layer Widening due to Excitotoxicity Occurs along In Vivo LTP Reinstatement and Contextual Fear Memory Recovery Neural Plast. (IF 3.1) Pub Date : 2022-9-27 Karina Hernández Mercado, Araceli Martínez Moreno, Luis Francisco Rodríguez Durán, Martha L. Escobar, Angélica Zepeda
The dentate gyrus (DG) is the gateway of sensory information arriving from the perforant pathway (PP) to the hippocampus. The adequate integration of incoming information into the DG is paramount in the execution of hippocampal-dependent cognitive functions. An abnormal DG granule cell layer (GCL) widening due to granule cell dispersion has been reported under hyperexcitation conditions in animal models
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Analysis of Muscular Electrical Activity and Blood Perfusion of Upper Extremity in Patients with Hemiplegic Shoulder Pain: A Pilot Study Neural Plast. (IF 3.1) Pub Date : 2022-9-27 Minghong Sui, Naifu Jiang, Luhui Yan, Chenxi Zhang, Jiaqing Liu, Tiebin Yan, Guanglin Li
Background. Hemiplegic shoulder pain (HSP) is a common symptom for post-stroke patients, which has a severely adverse impact on their rehabilitation outcomes. However, the cause of HSP has not been clearly identified due to its complicated multifactorial etiologies. As possible causes of HSP, the abnormality of both muscular electrical activity and blood perfusion remains lack of investigations. Objective
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Resting-State fMRI Whole Brain Network Function Plasticity Analysis in Attention Deficit Hyperactivity Disorder Neural Plast. (IF 3.1) Pub Date : 2022-9-26 Yi Tang, Shuxing Zheng, Yin Tian
Attention deficit hyperactivity disorder (ADHD) is a common mental disorder in children, which is related to inattention and hyperactivity. These symptoms are associated with abnormal interactions of brain networks. We used resting-state functional magnetic resonance imaging (rs-fMRI) based on the graph theory to explore the topology property changes of brain networks between an ADHD group and a normal
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Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain Neural Plast. (IF 3.1) Pub Date : 2022-08-29 Jie Liu, Jingyao Huang, Zhenjiang Zhang, Rui Zhang, Zhihao Zhang, Yongxin Liu, Baoyu Ma
Chronic pain is an enormous modern public health problem, with significant numbers of people debilitated by chronic pain from a variety of etiologies. Translocator protein 18 kDa (TSPO) was discovered in 1977 as a peripheral benzodiazepine receptor. It is a five transmembrane domain protein, mainly localized in the outer mitochondrial membrane. Recent and increasing studies have found changes in TSPO
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The Effectiveness of High-Frequency Repetitive Transcranial Magnetic Stimulation on Patients with Neuropathic Orofacial Pain: A Systematic Review of Randomized Controlled Trials Neural Plast. (IF 3.1) Pub Date : 2022-08-24 Yingxiu Diao, Yuhua Xie, Jiaxin Pan, Manxia Liao, Hao Liu, Linrong Liao
Background. Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the treatment of neuropathic orofacial pain (NOP). The consistency of its therapeutic efficacy with the optimal protocol is highly debatable. Objective. To assess the effectiveness of rTMS on pain intensity, psychological conditions, and quality of life (QOL) in individuals with NOP based on randomized controlled
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Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point Neural Plast. (IF 3.1) Pub Date : 2022-08-12 Xinglou Li, Meiling Luo, Yan Gong, Ning Xu, Congcong Huo, Hui Xie, Shouwei Yue, Zengyong Li, Yonghui Wang
Myofascial trigger point (MTrP), an iconic characteristic of myofascial pain syndrome (MPS), can induce cerebral cortex changes including altered cortical excitability and connectivity. The corresponding characteristically reactive cortex is still ambiguous. Seventeen participants with latent MTrPs underwent functional near-infrared spectroscopy (fNIRS) to collect cerebral oxygenation hemoglobin (Δ[oxy-Hb])
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High-Frequency Cerebellar rTMS Improves the Swallowing Function of Patients with Dysphagia after Brainstem Stroke Neural Plast. (IF 3.1) Pub Date : 2022-08-11 Ling-hui Dong, Xiaona Pan, Yuyang Wang, Guangtao Bai, Chao Han, Qiang Wang, Pingping Meng
Objective. To explore the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the swallowing motor area of the cerebellum in patients with dysphagia after brainstem stroke. Methods. A total of 36 patients with dysphagia after brainstem stroke were recruited and divided into 3 groups. Before stimulation, single-pulse transcranial magnetic stimulation (TMS) was used to determine
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Repetitive Transcranial Magnetic Stimulation for Neuropathic Pain and Neuropsychiatric Symptoms in Traumatic Brain Injury: A Systematic Review and Meta-Analysis Neural Plast. (IF 3.1) Pub Date : 2022-07-30 Xin Li, Tijiang Lu, Hong Yu, Jie Shen, Zhengquan Chen, Xiaoyan Yang, Zefan Huang, Yuqi Yang, Yufei Feng, Xuan Zhou, Qing Du
Neuropathic pain and neuropsychiatric symptoms are common complications reported by the traumatic brain injury (TBI) population. Although a growing body of research has indicated the effectiveness of repetitive transcranial magnetic stimulation (rTMS) for the management of neurological and psychiatric disorders, little evidence has been presented to support the effects of rTMS on neuropathic pain and
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Varied Response of EEG Rhythm to Different tDCS Protocols and Lesion Hemispheres in Stroke Subjects with Upper Limb Dysfunction Neural Plast. (IF 3.1) Pub Date : 2022-07-30 Chunfang Wang, Yuanyuan Chen, Peiqing Song, Hongli Yu, Jingang Du, Ying Zhang, Changcheng Sun
Transcranial direct current stimulation (tDCS) provides a way to modulate the cortical activity and promote motor rehabilitation following stroke. However, evidence indicates that the response to tDCS is highly variable. This study was aimed at exploring rhythmic response of Electroencephalography (EEG) to three tDCS protocols in stroke subjects. We hypothesize that tDCS protocols may interact with
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Aerobic Exercise and Human Visual Cortex Neuroplasticity: A Narrative Review Neural Plast. (IF 3.1) Pub Date : 2022-07-23 Dania Abuleil, Benjamin Thompson, Kristine Dalton
There is compelling evidence from animal models that physical exercise can enhance visual cortex neuroplasticity. In this narrative review, we explored whether exercise has the same effect in humans. We found that while some studies report evidence consistent with exercise-induced enhancement of human visual cortex neuroplasticity, others report no effect or even reduced neuroplasticity following exercise
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Low-Intensity Focused Ultrasound Alleviates Chronic Neuropathic Pain-Induced Allodynia by Inhibiting Neuroplasticity in the Anterior Cingulate Cortex Neural Plast. (IF 3.1) Pub Date : 2022-07-23 Bin Wang, Mo-Xian Chen, Shao-Chun Chen, Xiang-Jun Feng, Ye-Hui Liao, Yun-Xin Zhao, Jin-Shan Tie, Yao Liu, Li-Juan Ao
Low-intensity focused ultrasound (LIFU) is a potential noninvasive method to alleviate allodynia by modulating the central nervous system. However, the underlying analgesic mechanisms remain unexplored. Here, we assessed how LIFU at the anterior cingulate cortex (ACC) affects behavior response and central plasticity resulting from chronic constrictive injury (CCI). The safety of LIFU stimulation was
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Local and Distributed fMRI Changes Induced by 40 Hz Gamma tACS of the Bilateral Dorsolateral Prefrontal Cortex: A Pilot Study Neural Plast. (IF 3.1) Pub Date : 2022-07-16 Lucia Mencarelli, Lucia Monti, Sara Romanella, Francesco Neri, Giacomo Koch, Ricardo Salvador, Giulio Ruffini, Giulia Sprugnoli, Simone Rossi, Emiliano Santarnecchi
Over the past few years, the possibility of modulating fast brain oscillatory activity in the gamma (γ) band through transcranial alternating current stimulation (tACS) has been discussed in the context of both cognitive enhancement and therapeutic scenarios. However, the effects of tACS targeting regions outside the motor cortex, as well as its spatial specificity, are still unclear. Here, we present
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Peripheral Repetitive Transcranial Magnetic Stimulation(rTMS) for Idiopathic Facial Nerve Palsy: A Prospective, Randomized Controlled Trial Neural Plast. (IF 3.1) Pub Date : 2022-07-13 Zicai Liu, Dongling Xie, Xin Wen, Risheng Wang, Quan Yang, Huiyu Liu, Yuchun Shao, Tingting Liu
Purpose. The purpose of this study was to evaluate the clinical efficacy of peripheral repetitive transcranial magnetic stimulation (rTMS) in the treatment of idiopathic facial paralysis, to explore an ideal treatment scheme for idiopathic facial paralysis, and to provide evidence for clinical rehabilitation. Methods. 65 patients with idiopathic facial nerve palsy with the first onset were recruited
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Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy Neural Plast. (IF 3.1) Pub Date : 2022-07-11 Xu Qian, Ji-Qiang Ding, Xin Zhao, Xin-Wen Sheng, Zhao-Rui Wang, Qi-xing Yang, Jing-Jun Zheng, Jia-Gui Zhong, Teng-Yue Zhang, Shu-Qiao He, Wei-Dong Ji, Wei Li, Mei Zhang
Temporal lobe epilepsy (TLE) is a chronic neurological disorder that is often resistant to antiepileptic drugs. The pathogenesis of TLE is extremely complicated and remains elusive. Understanding the molecular mechanisms underlying TLE is crucial for its diagnosis and treatment. In the present study, a lithium-pilocarpine-induced TLE model was employed to reveal the pathological changes of hippocampus
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p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice Neural Plast. (IF 3.1) Pub Date : 2022-06-29 Kun Hou, Zhi-cheng Xiao, Hai-Long Dai
Cerebral ischemia/reperfusion (I/R) injury is a complex pathophysiological process that can lead to neurological function damage and the formation of cerebral infarction. The p38 MAPK pathway has attracted considerable attention in cerebral I/R injury (IRI), but little research has been carried out on its direct role in vivo. In this study, to observe the effects of p38 MAPK endogenous inhibition on
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Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury Neural Plast. (IF 3.1) Pub Date : 2022-06-09 Bin Han, Hui Zhao, Xingji Gong, Jinping Sun, Song Chi, Tao Liu, Anmu Xie
Hippocampal neuronal damage likely underlies cognitive impairment in vascular dementia (VaD). PPARγ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis. However, the role and the precise mechanism of how PGC-1α alleviates hippocampal neuronal injury remain unknown. To address this question, HT-22 cells, an immortalized hippocampal neuron cell line, with or without PGC-1α overexpression
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Electroacupuncture Alleviates Neuropathic Pain through Regulating miR-206-3p Targeting BDNF after CCI Neural Plast. (IF 3.1) Pub Date : 2022-06-09 Wenzhan Tu, Jingjing Yue, Xuqing Li, Qiaoyun Wu, Guanhu Yang, Shengcun Li, Qiangsan Sun, Songhe Jiang
Background. Electroacupuncture (EA) has benefits for neuropathic pain. However, the underlying mechanisms are still unknown. The current study explores the underlying mechanisms of EA in neuropathic pain of chronic constriction injury (CCI) rats. Material/Methods. Overall, 126 Sprague-Dawley (200-250 g) rats were divided into nine groups randomly: the sham-operated, CCI, CCI+EA, CCI+sham EA, CCI+NS
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Quantitative and Fiber-Selective Evaluation for Central Poststroke Pain Neural Plast. (IF 3.1) Pub Date : 2022-06-06 Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Guo-Xin Ni
The electrophysiological recording can be used to quantify the clinical features of central poststroke pain (CPSP) caused by different lesion locations. We aimed to explore the relationship between clinical features and lesion location in patients with CPSP using the current perception threshold (CPT) approach. Here, patients underwent the standardized CPT measure at five detection sites on both the