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Profiling Small RNA from Brain Extracellular Vesicles in Individuals with Depression Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-03-08 Pascal Ibrahim, Ryan Denniston, Haruka Mitsuhashi, Jennie Yang, Laura M Fiori, Dariusz Żurawek, Naguib Mechawar, Corina Nagy, Gustavo Turecki
Background Major depressive disorder (MDD) is a leading cause of disability with significant mortality risk. Despite progress in our understanding of the etiology of MDD, the underlying molecular changes in the brain remain poorly understood. Extracellular vesicles (EVs) are lipid-bound particles that can reflect the molecular signatures of the tissue of origin. We aimed to optimize a streamlined EV
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Blunted Cortisol Response to Acute Psychosocial Stress in Women with Premenstrual Dysphoric Disorder Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-03-07 Ajna Hamidovic, Fatimata Soumare
Background Despite being considered a stress-related condition, it is not known whether the hypothalamic-pituitary-adrenal (HPA) axis is dysfunctional in response to acute psychosocial stress in Premenstrual Dysphoric Disorder (PMDD). This is problematic because many women with PMDD report that they are not able to control their stress levels, and a blunted cortisol output has been identified in women
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Emotional blunting in depression in the PREDDICT clinical trial: inflammation-stratified augmentation of vortioxetine with celecoxib Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-03-02 Emma Sampson, Erhan Kavakbasi, Natalie T Mills, Hikaru Hori, K Oliver Schubert, Célia Fourrier, Bernhard T Baune
Background Emotional symptoms are recognized as a key feature in individuals with major depressive disorder. Previously, emotional blunting has been described both as a side-effect of antidepressant treatment and as a symptom of depression. Little is known on the change of emotional blunting during antidepressant treatment. Methods The PREDDICT trial is a randomized, placebo-controlled, 6-week trial
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Network meta-analysis indicates superior effects of omega-3 polyunsaturated fatty acids in preventing the transition to psychosis in individuals at clinical high-risk Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-02-24 Chengfeng Chen, Yongyan Deng, Yuling Li, Meiting Zhang, Tong Yu, Kun Xie, Wuyou Bao, Peiying Li, Ling Sun, Tianhong Zhang, Yikang Zhu, Bin Zhang
Background The efficacy of pharmacological and nutritional interventions in individuals at clinical high risk for psychosis (CHR-P) remains elusive. This study aims to investigate the efficacy of pharmacological and nutritional interventions in CHR-P and whether these interventions can enhance the efficacy of psychological treatments. Methods We systematically reviewed data from five databases until
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Histamine-3 receptor availability and glutamate levels in the brain: a PET-1H-MRS study of patients with schizophrenia and healthy controls Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-02-19 Atheeshaan Arumuham, Matthew M Nour, Mattia Veronese, Katherine Beck, Ellis Chika Onwordi, David J Lythgoe, Sameer Jauhar, Eugenii A Rabiner, Oliver D Howes
Background The histamine-3 receptor (H3R) may have a role in cognitive processes, through its action as a presynaptic heteroreceptor inhibiting the release of glutamate in the brain. To explore this, we examined anterior cingulate cortex (ACC) and striatum H3R availability in patients with schizophrenia, and characterised their relationships with glutamate levels in corresponding brain regions. Methods
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Ketone supplementation dampens subjective and objective responses to alcohol: evidence from a preclinical rat study and a randomized, cross-over trial in healthy volunteers Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-02-05 Xinyi Li, Zhenhao Shi, Dustin Todaro, Timothy Pond, Juliana Byanyima, Sianneh Vesslee, Rishika Reddy, Ravi Prakash Reddy Nanga, Gabriel Kass, Vijay Ramchandani, Henry R Kranzler, Janaina C M Vendruscolo, Leandro F Vendruscolo, Corinde E Wiers
Background Previous preclinical and human studies have shown that a high-fat ketogenic diet and ketone supplements (KS) are efficacious in reducing alcohol craving, alcohol consumption, and signs of alcohol withdrawal. However, the effects of KS on alcohol sensitivity are unknown. Methods In this single-blind, cross-over study, 10 healthy participants (3 females) were administered a single, oral dose
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Relapse Rates With Paliperidone Palmitate in Adult Patients With Schizophrenia: Results for the 6-Month Formulation From an Open-label Extension Study Compared to Real-world Data for the 1-Month and 3-Month Formulations Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-02-01 Ibrahim Turkoz, Mehmet Daskiran, Uzma Siddiqui, R Karl Knight, Karen L Johnston, Christoph U Correll
Background The three paliperidone palmitate (PP) long-acting injectable antipsychotic formulations, PP 1-month (PP1M), PP 3-month (PP3M), and PP 6-month (PP6M) have shown to reduce the risk of relapse in schizophrenia. The current phase-4 study constructed external comparator arms (ECAs) using real-world data for PP3M and PP1M and compared relapse prevention rates to PP6M from an open-label extension
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Making Sense Of Psychedelics In The CNS Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-01-30 Blake A Fordyce, Bryan L Roth
For centuries, ancient lineages have consumed psychedelic compounds from natural sources. In the modern era, scientists have since harnessed the power of computational tools, cellular assays, and behavioral metrics to study how these compounds instigate changes on molecular, cellular, circuit-wide, and system levels. Here, we provide a brief history of psychedelics and their use in science, medicine
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Enhanced risky choice in male rats elicited by the acute pharmacological stressor yohimbine involves prefrontal dopamine D1 receptor activation Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-01-12 Alexandra Münster, Julia Huster, Susanne Sommer, Corinna Traxler, Angeline Votteler, Wolfgang Hauber
Background Acute stress alters risk-based decision making, however, the underlying neural and neurochemical substrates are underexplored. Given their well-documented stress-inducing effects in humans and laboratory animals, glucocorticoids such as cortisol and corticosterone and the α2-adrenoceptor antagonist yohimbine represent potent pharmacological tools to mimic some characteristics of acute stress
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The ability to voluntarily regulate theta band activity affects how pharmacological manipulation of the catecholaminergic system impacts cognitive control Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-01-05 Astrid Prochnow, Moritz Mückschel, Elena Eggert, Jessica Senftleben, Christian Frings, Alexander Münchau, Veit Roessner, Annet Bluschke, Christian Beste
Background The catecholaminergic system influences response inhibition, but the magnitude of the impact of catecholaminergic manipulation is heterogeneous. Theoretical considerations suggest that the voluntary modulability of theta band activity can explain this variance. The study aimed to investigate to what extent interindividual differences in catecholaminergic effects on response inhibition depend
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A Systematic Review of the Molecular and Cellular Alterations Induced by Cannabis that may serve as Risk Factors for Bipolar Disorder Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-01-04 Alejandra Delgado-Sequera, Clara Garcia-Mompo, Ana Maria Gonzalez-Pinto, Hidalgo-Figueroa Maria, Berrocoso Esther
Background Cannabis use is a risk factor of psychiatric illness, such as bipolar disorder type-I (BDI). Indeed, cannabis use strongly influences the onset and clinical course of BDI, although the biological mechanisms underlying this interaction remain unknown. Therefore, we have reviewed the biological mechanisms affected by cannabis use that may trigger BD. Methods A systematic review was carried
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Divergent acute and enduring changes in 50-kHz ultrasonic vocalizations in rats repeatedly treated with amphetamine and dopaminergic antagonists: new insights on the role of dopamine in calling behavior Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2024-01-03 Marcello Serra, Giulia Costa, Emmanuel Onaivi, Nicola Simola
Background Rats emit 50-kHz ultrasonic vocalizations (USVs) in response to non-pharmacological and pharmacological stimuli, with addictive psychostimulants being the most effective drugs that elicit calling behavior in rats. Earlier investigations found that dopamine D1-like and D2-like receptors modulate the emission of 50-kHz USVs stimulated in rats by the acute administration of addictive psychostimulants
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Chronic stress-induced elevation of melanin-concentrating hormone in the locus coeruleus inhibits norepinephrine production and associated with depression-like behaviors in rats Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-12-23 Nurhumar Kurban, Yu Qin, Hui-Ling Zhao, Xiao Hu, Xi Chen, Yi-Yi Zhao, Yu-Shuo Peng, Hong-Bo Wang, Su-Ying Cui, Yong-He Zhang
Background Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that projects throughout the central nervous system, including the noradrenergic locus coeruleus (LC). Our previous study suggested that MCH/MCH receptor 1 (MCHR1) in the LC may be involved in the regulation of depression. The present study investigated whether the role of MCH/MCHR1 in the LC in depression-like behaviors
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Ketamine or ECT? What have we learned from the KetECT and ELEKT-D trials? Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-12-20 Joakim Ekstrand, Akihiro Takamiya, Axel Nordenskjold, George Kirov, Pascal Sienaert, Charles Kellner, Pouya Movahed Rad
Two recent clinical trials, KetECT and ELEKT-D, compared the effectiveness of ketamine and electroconvulsive therapy (ECT) for major depressive disorder. Notably, these trials reported marked differences in ECT’s clinical outcomes of, with remission rates of 63% for KetECT and a strikingly lower rate of 22% for ELEKT-D, while the remission rates for ketamine were 46% and 38%, respectively. Considering
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MiR-182-5p: a novel biomarker in the treatment of depression in CSDS-induced mice Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-11-30 Ya-Bin Zheng, Xiao-Ming Sheng, Xiang Jin, Wei Guan
Background Depression is a neuropsychiatric disease with high disability rate and mainly caused by the chronic stresses or genetic factors. There is increasing evidences that miRNAs play a critical role in the pathogenesis of depression. However, the underlying molecular mechanism for the pathophysiology of depression of miRNA remains entirely unclear so far. Methods We first established a Chronic
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Higher Levels of C-reactive Protein are Associated with Higher Cortical Surface Area and Lower Cortical Thickness in Youth with Bipolar Disorder Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-11-10 Suyi Shao, Yi Zou, Kody G Kennedy, Mikaela K Dimick, Bradley J MacIntosh, Benjamin I Goldstein
Background Inflammation is implicated in the neuropathology of bipolar disorder (BD). The association of C-reactive protein (CRP) with brain structure has been examined in relation to BD among adults but not youth. Methods Participants included 101 youth (BD, n=55; control group [CG], n=46; aged 13-20 years). Blood samples were assayed for levels of CRP. T1-weighted brain images were acquired to obtain
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Sleep deficits inter-link lower basal forebrain - posterior cingulate connectivity and perceived stress and anxiety bidirectionally in young men Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-11-04 Guangfei Li, Dandan Zhong, Bao Li, Yu Chen, Lin Yang, Chiang-Shan R Li
Background The basal nucleus of Meynert (BNM), a primary source of cholinergic projections to the cortex, plays key roles in regulating sleep-wake cycle and attention. Sleep deficit is associated with impairment in cognitive and emotional functions. However, whether or how cholinergic circuit, sleep, cognitive/emotional dysfunction are inter-related remains unclear. Methods We curated the Human Connectome
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Differential roles of oxytocin receptors in the prefrontal cortex and nucleus accumbens on cocaine self-administration and reinstatement of cued cocaine seeking in male rats Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-10-25 Rachal D Penrod, Makoto Taniguchi, Angela M Kearns, Jordan L Hopkins, Carmela M Reichel
Background Little is known about the specific roles of cortical and accumbal oxytocin receptors in drug use disorder. To better understand the importance of the endogenous oxytocin system in cocaine relapse behavior, we developed an adeno-associated viral vector (AAV) expressing short hairpin (sh) RNAs to selectively degrade the rat OxyR mRNA in vivo. Methods Male (Sprague-Dawley) rats received bilateral
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Elucidating the Mechanisms of Sodium Benzoate in Alzheimer's Disease: Insights from Quantitative Proteomics Analysis of Serum Samples Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-10-24 Chieh-Hsin Lin, Hsin-Yi Liao, Hsien-Yuan Lane, Chao-Jung Chen
Background N-methyl-D-aspartate receptors (NMDARs) are crucial components of brain function involved in memory and neurotransmission. Sodium benzoate is a promising NMDAR enhancer and has been proven to be a novel, safe and efficient therapy for patients with Alzheimer’s disease (AD). However, in addition to the role of sodium benzoate as an NMDA enhancer, other mechanisms of sodium benzoate in treating
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Neural, Anti-inflammatory, and Clinical Effects of Transauricular Vagus Nerve Stimulation in Major Depressive Disorder: A Systematic Review Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-10-23 Joao Parente, Anna Carolyna Gianlorenco, Ingrid Rebello-Sanchez, Minkyung Kim, Jose Mario Prati, Chi Kyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni
Objectives The discovery of effective treatments for major depressive disorder (MDD) may help target different brain pathways. Invasive vagus nerve stimulation (VNS) is an effective neuromodulation technique for the treatment of MDD; however, the effectiveness of the noninvasive technique, transauricular VNS (taVNS), remains unknown. Moreover, a mechanistic understanding of the neural effects behind
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The impact of heroin self-administration and environmental enrichment on ventral tegmental CRF1 receptor expression Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-10-20 Ewa Galaj, Eddy D Barrera, Kirk Persaud, Rudolf Nisanov, Apoorva Vashisht, Hindy Goldberg, Nima Patel, Hayley Lenhard, Zhi-Bing You, Eliot L Gardner, Robert Ranaldi
Background There is a strong link between chronic stress and vulnerability to drug abuse and addiction. Corticotropin releasing factor (CRF) is central to the stress response that contributes to continuation and relapse to heroin abuse. Chronic heroin exposure can exacerbate CRF production, leading to dysregulation of the midbrain CRF-dopamine-glutamate interaction Methods and Results Here we investigated
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Integrative analyses of scRNA-seq, bulk mRNA-seq, and DNA methylation profiling in depressed suicide brain tissues Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-09-29 Yalan Zhou, Lan Xiong, Jianhua Chen, Qingzhong Wang
Background Suicidal behaviors have become a serious public health concern globally due to the economic and human cost of suicidal behavior to individuals, families, communities, and society. However, the underlying etiology and biological mechanism of suicidal behavior remains poorly understood. Methods We collected different single omic data, including scRNA-seq, bulk mRNA-seq, DNA methylation microarrays
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Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-09-25 Xue Dong,Simon Zhornitsky,Wuyi Wang,Thang M Le,Yu Chen,Shefali Chaudhary,Chiang-Shan R Li,Sheng Zhang
BACKGROUND Previous studies have focused on both ventral striatum (VS) and dorsal striatum (DS) in characterizing dopaminergic deficits in addiction. Animal studies suggest VS and DS dysfunction each in association with impulsive and compulsive cocaine use during early and later stages of addiction. However, few human studies have aimed to distinguish the roles of VS and DS dysfunction in cocaine misuse
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New Study Reveals Long-Term Effects of MDMA on the Brain's Glutamate-Glutamine Complex. Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-09-25 Apochi Obed Okwoli
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Distinct neural representations and cognitive behaviors attributable to naturally-developed active avoidance or reactive escape strategies in the male rat Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-09-18 Liang Jing, Chen Ma, Lin Xu, Gal Richter-Levin
Background The high individual variability in coping with stress is often attributed to either genetic background differences, sustained environmental conditions, or a combination of both. However, the neural mechanisms underlying coping style variability are yet poorly understood. Methods Here we examined the impact of a single extended emotional challenge on coping style variability, and the associated
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The atypical dopamine transporter inhibitor CE-158 enhances dopamine neurotransmission in the prefrontal cortex of male rats: a behavioral, electrophysiological and microdialysis study Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-09-17 Claudia Sagheddu, Enzo Cancedda, Farshid Bagheri, Predrag Kalaba, Anna Lisa Muntoni, Jana Lubec, Gert Lubec, Fabrizio Sanna, Marco Pistis
Background Dopamine plays a key role in several physiological functions such as motor control, learning and memory, motivation and reward. The atypical dopamine transporter inhibitor CE-158 has been recently reported to promote behavioral flexibility and restore learning and memory in aged rats. Methods Adult male rats were intraperitoneally administered for 1 or 10 days with CE-158 at the dose of
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Sex differences in plasma, adipose tissue, and central accumulation of cannabinoids, and behavioural effects of oral cannabis consumption in male and female C57BL/6 mice Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-09-13 Nada Sallam, Colleen Peterson, Samantha L Baglot, Yuta Kohro, Tuan Trang, Matthew N Hill, Stephanie L Borgland
Background Cannabis edibles are an increasingly popular form of cannabis consumption. Oral consumption of cannabis has distinct physiological and behavioural effects than injection or inhalation. An animal model is needed to understand the pharmacokinetics and physiological effects of oral cannabis consumption in rodents as a model for human cannabis edible use. Methods Adult male and female C57BL/6
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Schizophrenia patients discharged on clozapine plus long-acting injectable antipsychotics from a public psychiatric hospital in Taiwan, 2006-2021 Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-24 Ta-Chun Lin, Ching-Hua Lin
Background Some schizophrenia patients treated with clozapine experience an inadequate response and adherence problems. The purpose of this study was to compare time to rehospitalization within 6 months in schizophrenia patients discharged on three clozapine regimens. Additionally, the temporal trend of prescription rate in each group was also explored. Methods Schizophrenia patients discharged from
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Association of Prolactin, Oxytocin, and Homocysteine With the Clinical and Cognitive Features of a First Episode of Psychosis Over a 1-Year Follow-Up. Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-11-24 Maria Hidalgo-Figueroa,Alejandro Salazar,Cristina Romero-López-Alberca,Karina S MacDowell,Borja García-Bueno,Miquel Bioque,Miquel Bernardo,Mara Parellada,Ana González-Pinto,M Paz García-Portilla,Antonio Lobo,Roberto Rodriguez-Jimenez,Esther Berrocoso,Juan C Leza,,
BACKGROUND The clinical debut of schizophrenia is frequently a first episode of psychosis (FEP). As such, there is considerable interest in identifying associations between biological markers and clinical or cognitive characteristics that help predict the progression and outcome of FEP patients. Previous studies showed that high prolactin, low oxytocin, and high homocysteine are factors associated
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Cucurbitacin B exerts significant antidepressant-like effects in a chronic unpredictable mild stress model of depression: Involvement of the hippocampal BDNF-TrkB system Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-21 Jian-Bin Ge, Bo Jiang, Tian-Shun Shi, Wei-Yu Li, Wei-Jia Chen, Bao-Lun Zhu, Zheng-Hong Qin
Background Although depression has been a serious neuropsychiatric disorder worldwide, current antidepressants used in clinical practice have various weaknesses including delayed onset and low rates of efficacy. Recently, the development of new antidepressants from natural herbal medicine has become one of the important research hotspots. Cucurbitacin B is a natural compound widely distributed in the
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(S)-ketamine, but not (R)-ketamine shows acute effects on depression-like behavior and sleep-wake architecture in rats Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-14 Szabolcs Koncz, Noémi Papp, Dóra Pothorszki, György Bagdy
Background Racemic ketamine consists of two enantiomers, namely (R)ketamine and (S)ketamine, with distinguishable pharmacological properties. Both enantiomers have been reported to show rapid antidepressant effects in rodents. Currently, the (S)enantiomer has been approved for the treatment of major depression, while (R)ketamine failed to show antidepressant effect in recent clinical studies. Major
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Aromatase inhibition and electroconvulsive seizures in adolescent rats: antidepressant and long-term cognitive sex differences Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-10 Sandra Ledesma-Corvi, M Julia García-Fuster
Background We recently showed sex differences in the antidepressant-like potential of electroconvulsive seizures (ECS) in adolescent rats; while it worked for male rats it rendered inefficacious in females. Since sex steroids might be important modulators of these sex disparities, we evaluated the role of estrogens in the differential response induced by adolescent ECS. Moreover, given the literature
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Stress hormone dynamics are coupled to brain serotonin 4 receptor availability in unmedicated patients with Major Depressive Disorder – a NeuroPharm study Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-05 Gunild M Vulpius, Kristin Köhler-Forsberg, Brice Ozenne, Søren V Larsen, Arafat Nasser, Claus Svarer, Nic Gillings, Sune H Keller, Martin B Jørgensen, Gitte M Knudsen, Vibe G Frokjaer
Background A prominent finding in Major Depressive Disorder (MDD) is distorted stress hormone dynamics, which is regulated by serotonergic brain signaling. An interesting feature of the cerebral serotonin system is the serotonin 4 receptor (5-HT4R), which is lower in depressed relative to healthy individuals, and also has been highlighted as a promising novel antidepressant target. Here, we test the
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In Vitro Comparison of Ulotaront (SEP-363856) and Ralmitaront (RO6889450) - Two TAAR1 Agonist Candidate Antipsychotics Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-04 Richard Ågren, Nibal Betari, Marcus Saarinen, Hugo Zeberg, Per Svenningsson, Kristoffer Sahlholm
Background Trace amine-associated receptor-1 (TAAR1) agonists have been proposed as potential antipsychotics, with ulotaront and ralmitaront having reached clinical trials. While ulotaront demonstrated efficacy in a recent Phase II trial, a corresponding study studies of ralmitaront failed to show efficacy as a monotherapy. In addition to TAAR1 agonism, ulotaront is a partial agonist at the serotonin
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Longitudinal Impact of the COVID-19 Pandemic on Stress and Occupational Well-Being of Mental Health Professionals: An International Study Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-02 Cary S Kogan, José A Garcia-Pacheco, Tahilia J Rebello, Madeline I Montoya, Rebeca Robles, Brigitte Khoury, Maya Kulygina, Chihiro Matsumoto, Jingjing Huang, María Elena Medina-Mora, Oye Gureje, Dan J Stein, Pratap Sharan, Wolfgang Gaebel, Shigenobu Kanba, Howard F Andrews, Michael C Roberts, Kathleen M Pike, Min Zhao, José Luis Ayuso, Karolina Sadowska, Karen Maré, Keith Denny, Geoffrey M Reed
Background Increased levels of occupational stress among health professionals during the COVID-19 pandemic have been documented. Few studies examined the effects of the pandemic on mental health professionals despite the heightened demand for their services. Method A multilingual, longitudinal, global survey was conducted at three time points during the pandemic among members of the WHO’s Global Clinical
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Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-25 Wei-Chen Lin, Tung-Ping Su, Cheng-Ta Li, Hui-Ju Wu, Ya-Mei Bai, Yu-Li Liu, Pei-Chi Tu, Mu-Hong Chen
Background The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low-dose ketamine infusion has not been determined. Methods The NFL concentrations of 71 patients with TRD and 17 healthy controls were assessed. Patients with TRD were randomly administered a single infusion
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Rolipram ameliorates memory deficits and depression-like behavior in APP/PS1/tau triple transgenic mice: involvement of neuroinflammation and apoptosis via cAMP signaling Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-25 Yi-Fan Cong, Fu-Wang Liu, Li Xu, Shuang-Shuang Song, Xu-Ri Shen, Dong Liu, Xue-Qin Hou, Han-Ting Zhang
Background Alzheimer’s disease (AD) and depression often co-occur, and inhibition of phosphodiesterase-4 (PDE4) has been shown to ameliorate neurodegenerative illness. Therefore, we explored whether PDE4 inhibitor rolipram might also improve the symptoms of comorbid AD and depression. Methods APP/PS1/tau mice (10 months old) were treated with or without daily intraperitoneal injections of rolipram
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A Synthetic External Control Study Comparing the Clinical Efficacy of Wendan Decoction and 19 Antidepressants Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-25 Yuting Yang, Rui Chen, Caixia Li, Qingshan Zheng, Yinghua Lv, Lujin Li, Hongsheng Tan
Background Wendan decoction (WDD) has been used as a treatment for depression in China since the Tang Dynasty. However, high-quality evidence for this is lacking. This study proposed a novel synthetic external control method to evaluate its clinical efficacy. Methods Clinical trials of WDD for major depression were searched for using public databases. The rate of change of the Hamilton Depression Scale
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Ventral hippocampal input to infralimbic cortex is necessary for the therapeutic-like effects of extinction in stressed rats Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-22 Denisse Paredes, David A Morilak
Background Post-traumatic stress disorder is characterized by deficits in cognitive flexibility related to dysfunction of the medial prefrontal cortex (mPFC). Exposure therapy can effectively reverse these deficits. Fear extinction in rodents bears similarity to exposure therapy. Extinction reverses chronic stress-induced deficits in cognitive flexibility on the attentional set-shifting test (AST)
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Long-Term Efficacy and Safety of Paliperidone 6-Month Formulation: An Open-Label 2-Year Extension of a 1-Year Double-Blind Study in Adult Participants With Schizophrenia Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-22 Dean Najarian, Ibrahim Turkoz, R Karl Knight, Silvana Galderisi, Hector F Lamaison, Piotr Zalitacz, Suresh Aravind, Ute Richarz
Background Paliperidone palmitate 6-month (PP6M) demonstrated noninferiority to paliperidone palmitate 3-month in preventing relapse in patients with schizophrenia in a phase 3 double-blind (DB) study (NCT03345342). Here, we report long-term efficacy and safety results from a 2-year single-arm, open-label extension (OLE; NCT04072575) of this DB study. Methods Participants who completed the DB study
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Differential impacts of endogenous antioxidants on clinical symptoms and cognitive function in acute and chronic schizophrenia patients Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-09 Chieh-Hsin Lin, Tin-May Li, Yu-Jhen Huang, Shaw-Ji Chen, Hsien-Yuan Lane
Background Impaired antioxidant defense is implicated in the pathophysiology of schizophrenia; and superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) are three first-line endogenous antioxidants. Various cognitive functions decline differently during schizophrenia course. The characteristic roles of the three antioxidants in clinical and cognitive profiles in acute and chronic phases
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Event-Related Potential Markers of Suicidality in Adolescents Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-09 Deniz Doruk Camsari, Charles P Lewis, Ayse Irem Sonmez, Can Ozger, Parmis Fatih, Deniz Yuruk, Julia Shekunov, Jennifer L Vande Voort, Paul E Croarkin
Background Implicit cognitive markers may assist with the prediction of suicidality beyond clinical risk factors. The aim of this study was to investigate neural correlates associated with Death/Suicide Implicit Association Test (DS-IAT) via event-related potentials (ERP) in suicidal adolescents. Methods Thirty inpatient adolescents with suicidal ideations and behaviors (SIBS), and thirty healthy controls
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Inhibitory neurons in nucleus tractus solitarius are involved in decrease of heart rate variability and development of depression-like behaviors in temporal lobe epilepsy Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-07 Guliqiemu Aimaier, Kun Qian, Huateng Cao, Weifeng Peng, Zhe Zhang, Jing Ding, Xin Wang
Background Diminished heart rate variability (HRV) has been observed in epilepsy, especially in epilepsy with depressive disorders. However, the underlying mechanism remains elusive. Methods We studied HRV, spontaneous recurrent seizures (SRSs) and depression-like behaviors in different phases of pilocarpine-induced temporal lobe epilepsy (TLE) in mice. Single-cell RNA sequencing analysis was used
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Relationships between Adherence to Guideline Recommendations for Pharmacological Therapy among Clinicians and Psychotic Symptoms in Patients with Schizophrenia Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-28 Fumitoshi Kodaka, Kazutaka Ohi, Yuka Yasuda, Michiko Fujimoto, Hidenaga Yamamori, Naomi Hasegawa, Satsuki Ito, Kentaro Fukumoto, Junya Matsumoto, Kenichiro Miura, Norio Yasui-Furukori, Ryota Hashimoto
Background Clinician adherence to guideline recommendations in the pharmacological therapy of schizophrenia is important for favorable patient outcomes. To evaluate whether prescriptions followed the guidelines for pharmacological therapy of schizophrenia, we recently developed a summary indicator of multiple quality indicators: the individual fitness score (IFS). It is unclear whether adherence to
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Reelin plasma levels identify cognitive decline in Alcohol Use Disorder subjects during early abstinence: the influence of APOE4 expression Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-23 Berta Escudero, Marta Moya, Leticia López-Valencia, Francisco Arias, Laura Orio
Background Apolipoprotein E (APOE)-4 isoform, Reelin and Clusterin share VLDLR and APOER2 receptors and are related to cognition in neuropsychiatric disorders. These proteins are expressed in plasma and brain but studies involving plasma expression and cognition are scarce. Methods We studied the peripheral expression (plasma and PBMCs) of these proteins in 24 Alcohol Use Disorder (AUD)-diagnosed middle-aged
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Phase 2 Results Indicate Evenamide, A Selective Modulator of Glutamate Release, Is Associated With Clinically Important Long-Term Efficacy When Added to an Antipsychotic in Patients With Treatment-Resistant Schizophrenia. Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-08-29 Ravi Anand,Alessio Turolla,Giovanni Chinellato,Arjun Roy,Richard D Hartman
Results from a pilot, 6-week, randomized, open-label, rater-blinded study, with 46-week extension, indicate very good tolerability with exceptional, clinically important, increasing efficacy of evenamide (7.5, 15, and 30 mg bid), a glutamate modulator, as add-on treatment to antipsychotics in 161 treatment-resistant, schizophrenia patients. Ninety-five percent of patients completed 6 weeks (1 discontinued
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Activation of the mu-delta opioid receptor heteromers blocks morphine rewarding effects Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-22 Ariadna Requana Aradas, Youssra Djaboub, Isabelle McCort-Tranchepain, Zuzana Hajasova, Loïc Clémenceau, Corinne Canestrelli, Anika Mann, Stefan Schulz, Angélique Delaval, Francine Acher, Dominique Massotte, Florence Noble, Nicolas Marie
Background Evidence has accumulated demonstrating the existence of opioid receptor heteromers and recent data suggest that targeting these heteromers could reduce opioid side effects while retaining therapeutic effects. Indeed, CYM51010 characterised as a MOR (mu opioid receptor)/DOR (delta opioid receptor) heteromers preferring agonist promoted antinociception comparable to morphine but with less
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Nociceptin Receptor Antagonism Modulates Electrophysiological Markers of Reward Learning. Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-07-31 Ann M Iturra-Mena,Brian D Kangas,Diego A Pizzagalli
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Weight Gain and Metabolic Changes in Patients With First-Episode Psychosis or Early-Phase Schizophrenia Treated With Olanzapine: A Meta-analysis Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-16 Christoph U Correll, Mikkel Højlund, Christine Graham, Mark S Todtenkopf, David McDonnell, Adam Simmons
Background Patients with first-episode psychosis or early-phase schizophrenia are susceptible to olanzapine-associated weight gain and cardiometabolic dysregulation. This meta-analysis characterized weight and metabolic effects observed during olanzapine treatment in randomized clinical trials in this vulnerable patient population. Methods PubMed, EMBASE, and Dialog were searched for randomized controlled
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New Insights into the Roles of p53 in Central Nervous System Diseases Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-15 Haili Li, Ze Zhang, Huixin Li, Xinyu Pan, Yue Wang
The transcription factor p53, a widely accepted tumor suppressor, regulates the expression of many oncogenes and their downstream signaling pathways, resulting in a series of biological outcomes. Mutations and deletions of the p53 gene often occur in tumor tissues and are involved in their development. In addition to its role in tumors, p53 has a widespread expression in the brain and participates
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BTRX-246040 acts through the ventrolateral periaqueductal gray to exert antidepressant-relevant actions in mice Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-09 Zhenlong Li, Yuanyuan Xu, Rourou Li, Zhenyu Sheng, Xinya Chen, Xueman Liu, Chau-Shoun Lee, Hsien-Yu Peng, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Dylan Chou
Background BTRX-246040, a nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor antagonist, is being developed for the treatment of depressive patients. However, the underlying mechanism of this potential antidepressant is still largely unclear. Here, we studied the antidepressant-related actions of BTRX-246040 in the ventrolateral periaqueductal gray (vlPAG). Methods The tail suspension test (TST)
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Serotonergic neurotransmission in limbic regions may reflect therapeutic response of depressive patients: A PET study with 11C-WAY-100635 and 18F-MPPF Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-09 Soichiro Kitamura, Yasuyuki Kimura, Keisuke Takahata, Sho Moriguchi, Manabu Kubota, Hitoshi Shimada, Hironobu Endo, Yuhei Takado, Kazunori Kawamura, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
Background Central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission has been implicated in the etiology of depression. Most antidepressants ameliorate depressive symptoms by increasing 5-HT at synaptic clefts but their effect on 5-HT receptors has yet to be clarified. 11C-WAY-100635 and 18F-MPPF are positron emission tomography (PET) radioligands for 5-HT1A receptors. While binding of both ligands
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Key Risk Genes Identified from the Postmortem Brain of Patients with Major Depressive Disorder and Their Potential Clinical Applications Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-05-26 Qishuai Zhuang, Jingxian Wang, Xiaobing Li, Xiaoning Zhang, Yue Wang
Background Major depressive disorder (MDD) is a type of emotional dysfunction, and its pathogenesis has not been fully elucidated. Specifically, the key molecules in depression-related brain regions that are involved in this disease and their contributions to this disease are currently unclear. Methods GSE53987 and GSE54568 were selected from the Gene Expression Omnibus (GEO) database. The data were
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Chronic 3,4-Methylenedioxymethamphetamine (MDMA) use is related to glutamate and GABA concentrations in the striatum, but not in the anterior cingulate cortex Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-05-26 Josua Zimmermann, Niklaus Zölch, Rebecca Coray, Francesco Bavato, Nicole Friedli, Markus R Baumgartner, Andrea E Steuer, Antje Opitz, Annett Werner, Georg Oeltzschner, Erich Seifritz, Ann Kathrin Stock, Christian Beste, David M Cole, Boris B Quednow
Background 3,4-Methylenedioxymethamphetamine (MDMA) is a widely used recreational substance inducing acute release of serotonin. Previous studies in chronic MDMA users demonstrated selective adaptations in the serotonin system, which were assumed to be associated with cognitive deficits. However, serotonin functions are strongly entangled with glutamate as well as γ-aminobutyric acid (GABA) neurotransmission
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A Stress Protein Based Suicide Prediction Score and relationship to reported Early Life Adversity and Recent Life Stress Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-05-26 Mark D Underwood, Hanga Galfalvy, Shu-chi Hsiung, Yan Liu, Norman R Simpson, Mihran J Bakalian, Gorazd B Rosoklija, Andrew J Dwork, Victoria Arango, J John Mann
Background The hypothalamic-pituitary-adrenal (HPA) axis is a major stress response system, and excessive HPA responses can impact major depressive disorder and suicide. We examined relationships between reported early life adversity (ELA), recent life stress (RLS), suicide, and corticotropin releasing hormone (CRH), CRH binding protein (CRHBP), FK506-binding protein (FKBP5), glucocorticoid receptor
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Interventions for Trauma-Related Nightmare: Where Are We Now? Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-06-23 Yuru Nie,Ye Zhang,Rong Ren,Larry D Sanford,Michael V Vitiello,Xiangdong Tang
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Erythrocyte membrane fatty acid composition as a potential biomarker for depression Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-05-23 Ting Liu, Lu Wang, Jimin Guo, Tingyu Zhao, Hui Tang, Fang Dong, Chuanyue Wang, Jindong Chen, Mimi Tang
Background Major Depressive Disorders is a chronic and severe psychiatric disorder with poor prognosis and quality of life. Abnormal erythrocyte fatty acid composition in the depressed patients were found in our previous study, but the relationship between erythrocyte membrane fatty acid levels and different severity of depressive and anxiety symptoms remains to be explored. Methods This cross-sectional
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Characterization of two novel phosphodiesterase 2 inhibitors Hcyb1 and PF-05180999 on depression- and anxiety-like behavior Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-05-20 Yuqing Yan, Yuhan Zhao, Yue Lu, Abhinav P Acharya, Wei Wang, Chang-Guo Zhan, Jianghong Ye, Fu Du, Xiongwei Zhu, Ying Xu
Background PDE2A represents a novel target for new therapies addressing psychiatric disorders. To date, the development of PDE2A inhibitors suitable for human clinical evaluation has been hampered by the poor brain accessibility and metabolic stability of the available compounds. Methods Corticosterone (CORT)-induced neuronal cell lesion and restraint stress mouse model were used to measure the neuroprotective
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Medial prefrontal cortex to medial septum pathway activation improves cognitive flexibility in rats Int. J. Neuropsychopharmacol. (IF 4.8) Pub Date : 2023-05-19 David M Bortz, Catalina M Feistritzer, Anthony A Grace
Background The medial prefrontal cortex (mPFC) is necessary for cognitive flexibility and projects to medial septum (MS). MS activation improves strategy switching, a common measure of cognitive flexibility, via its ability to regulate midbrain dopamine (DA) neuron population activity. We hypothesized that the mPFC to MS pathway may be the mechanism by which the MS regulates strategy switching and