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Tracing the development of learned song preferences in the female zebra finch brain with functional magnetic resonance imaging Dev. Neurobiol. (IF 3.0) Pub Date : 2024-03-11 Payal Arya, Nancy H. Kolodny, Sharon M. H. Gobes
In sexually dimorphic zebra finches (Taeniopygia guttata), only males learn to sing their father's song, whereas females learn to recognize the songs of their father or mate but cannot sing themselves. Memory of learned songs is behaviorally expressed in females by preferring familiar songs over unfamiliar ones. Auditory association regions such as the caudomedial mesopallium (CMM; or caudal mesopallium)
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S100Z is expressed in a lateral subpopulation of olfactory receptor neurons in the main olfactory system of Xenopus laevis Dev. Neurobiol. (IF 3.0) Pub Date : 2024-03-05 Melina Kahl, Thomas Offner, Alena Trendel, Lukas Weiss, Ivan Manzini, Thomas Hassenklöver
In contrast to other S100 protein members, the function of S100 calcium‐binding protein Z (S100Z) remains largely uncharacterized. It is expressed in the olfactory epithelium of fish, and it is closely associated with the vomeronasal organ (VNO) in mammals. In this study, we analyzed the expression pattern of S100Z in the olfactory system of the anuran amphibian Xenopus laevis. Using immunohistochemistry
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Valproate treatment induces age- and sex-dependent neuronal activity changes according to a patch clamp study Dev. Neurobiol. (IF 3.0) Pub Date : 2023-12-20 Tímea Májer, Veronika Bódi, Viktor Kelemen, Attila Szűcs, Petra Varró, Ildikó Világi
Autism spectrum disorder is a heterogeneous neurodevelopmental disorder characterized by impaired social interactions, restricted, and stereotyped behaviors. The valproic acid model is one of the most recognized and broadly used models in rats to induce core symptoms of this disorder. Comorbidity of epilepsy and autism occurs frequently, due to similar background mechanisms that include the imbalance
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LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury Dev. Neurobiol. (IF 3.0) Pub Date : 2023-12-17 Yang Liu, You-jia Xu
After peripheral nervous system injury, Schwann cells (SCs) can repair axons by providing a growth-promoting microenvironment. The aim of this study is to explore the effects and mechanisms of LKB1 and CRMP1 on the repair of sciatic nerve injury (SNI). The expressions of LKB1 and CRMP1 were changed in rats with SNI from 12 h to 4 weeks by hematoxylin–eosin staining, RT-PCR assay, immunohistochemical
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Somatostatin affects GnRH neuronal development and migration and stimulates olfactory-related fiber fasciculation Dev. Neurobiol. (IF 3.0) Pub Date : 2023-12-10 Shizuko Murakami, Hiroko Ohki-Hamazaki, Yasuo Uchiyama
Transient expression of somatostatin (SST) has been observed in the olfactory epithelium (OE) and nerves of chick embryos. Intense expression of SST in these regions on embryonic days (E) 5–8 coincides with the migration of neurons producing gonadotropin-releasing hormone (GnRH) from the OE to the forebrain (FB), suggesting that SST plays a role in the development of GnRH neurons. Using in ovo electroporation
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Preparation of astrocytes by directed differentiation of pluripotent stem cells and somatic cell transdifferentiation Dev. Neurobiol. (IF 3.0) Pub Date : 2023-10-03 Hangjie Chen, Kang Zheng, Mengsheng Qiu, Junlin Yang
Astrocytes (ACs) are the most widely distributed cells in the mammalian central nervous system, which are essential for the function and homeostasis of nervous system. Increasing evidence indicates that ACs also participate in the development of many neurological diseases and repair after nerve injury. ACs cultured in vitro provide a cellular model for studying astrocytic development, function, and
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5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons Dev. Neurobiol. (IF 3.0) Pub Date : 2023-09-15 Delaney R. Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H. Roossien
Serotonergic neurons produce extensively branched axons that fill most of the central nervous system, where they modulate a wide variety of behaviors. Many behavioral disorders have been correlated with defective serotonergic axon morphologies. Proper behavioral output therefore depends on the precise outgrowth and targeting of serotonergic axons during development. To direct outgrowth, serotonergic
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Ten-m3 plays a role in the formation of thalamostriatal projections Dev. Neurobiol. (IF 3.0) Pub Date : 2023-09-13 Heidi Tran, Atomu Sawatari, Catherine A. Leamey
The importance of the thalamostriatal pathway for a myriad of brain functions is becoming increasingly apparent. Little is known about the formation of this pathway in mice. Further, while Ten-m3, a member of the Ten-m/teneurin/Odz family, is implicated in the proper wiring of mature thalamostriatal projections, its developmental time course is unknown. Here, we describe the normal development of thalamostriatal
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A quantitative characterization of early neuron generation in the developing zebrafish telencephalon Dev. Neurobiol. (IF 3.0) Pub Date : 2023-09-07 Glòria Casas Gimeno, Ekaterina Dvorianinova, Carla-Sophie Lembke, Emma S. C. Dijkstra, Hussam Abbas, Yuanyuan Liu, Judith T. M. L. Paridaen
The adult brain is made up of anatomically and functionally distinct regions with specific neuronal compositions. At the root of this neuronal diversity are neural stem and progenitor cells (NPCs) that produce many neurons throughout embryonic development. During development, NPCs switch from initial expanding divisions to neurogenic divisions, which marks the onset of neurogenesis. Here, we aimed
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Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats Dev. Neurobiol. (IF 3.0) Pub Date : 2023-07-24 Sabrina Salberg, Matthew Macowan, Glenn R. Yamakawa, Jaimie K. Beveridge, Melanie Noel, Benjamin J. Marsland, Richelle Mychasiuk
Adolescent chronic pain is a growing public health epidemic. Our understanding of its etiology is limited; however, several factors can increase susceptibility, often developing in response to an acute pain trigger such as a surgical procedure or mild traumatic brain injury (mTBI), or an adverse childhood experience (ACE). Additionally, the prevalence and manifestation of chronic pain is sexually dimorphic
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Short-term hindlimb unloading negatively affects dopaminergic transmission in the nigrostriatal system of mice Dev. Neurobiol. (IF 3.0) Pub Date : 2023-07-24 Alexandra A. Naumova, Ekaterina A. Oleynik, Anna V. Khramtsova, Svetlana D. Nikolaeva, Elena V. Chernigovskaya, Margarita V. Glazova
The nigrostriatal system composed of the dorsal striatum and the substantia nigra (SN) is highly involved in the control of motor behavior. Various extremal and pathological conditions as well as social isolation (SI) may cause an impairment of locomotor function; however, corresponding alterations in the nigrostriatal dopaminergic pathway are far from full understanding. Here, we analyzed the effect
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Lipid peroxidation and neuroinflammation: A possible link between maternal fructose intake and delay of acquisition of neonatal reflexes in Wistar female rats Dev. Neurobiol. (IF 3.0) Pub Date : 2023-07-12 Facundo H. Prado Spalm, Marié L. Cuervo Sánchez, Natalia E. Furland, Ana S. Vallés
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The effects of Wnt, BMP, and Notch signaling pathways on cell proliferation and neural differentiation in a song control nucleus (HVC) of Lonchura striata Dev. Neurobiol. (IF 3.0) Pub Date : 2023-07-11 Jie Bing, Jing Sun, Rui Zhao, Lina Sun, Chao Xi, Jin Liu, Xinwen Zhang, Shaoju Zeng
There is obvious sexual dimorphism in the song control system of songbirds. In the higher vocal center (HVC), cell proliferation and neuronal differentiation contribute to the net addition of neurons. However, the mechanism underlying these changes is unclear. Given that Wnt, Bmp, and Notch pathways are involved in cell proliferation and neuronal differentiation, no reports are available to study the
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Exploring behavioral phenotypes in a mouse model of fetal alcohol spectrum disorders Dev. Neurobiol. (IF 3.0) Pub Date : 2023-07-11 Tammy R. Chaudoin, Stephen J Bonasera, Anna Dunaevsky, Ragunathan Padmashri
Fetal alcohol spectrum disorders are one of the leading causes of developmental abnormalities worldwide. Maternal consumption of alcohol during pregnancy leads to a diverse range of cognitive and neurobehavioral deficits. Although moderate-to-heavy levels of prenatal alcohol exposure (PAE) have been associated with adverse offspring outcomes, there is limited data on the consequences of chronic low-level
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Development of the hippocampal CA2 region and the emergence of social recognition Dev. Neurobiol. (IF 3.0) Pub Date : 2023-06-16 Emma J. Diethorn, Elizabeth Gould
Social memories formed in early life, like those for family and unrelated peers, are known to contribute to healthy social interactions throughout life, although how the developing brain supports social memory remains relatively unexplored. The CA2 subregion of the hippocampus is involved in social memory function, but most literature on this subject is restricted to studies of adult rodents. Here
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Characterization of neuropathology in ovine CLN5 and CLN6 neuronal ceroid lipofuscinoses (Batten disease) Dev. Neurobiol. (IF 3.0) Pub Date : 2023-05-28 Nadia L. Mitchell, Katharina N. Russell, Graham K. Barrell, Imke Tammen, David N. Palmer
Sheep with naturally occurring CLN5 and CLN6 forms of neuronal ceroid lipofuscinoses (Batten disease) share the key clinical features of the human disease and represent an ideal model system in which the clinical efficacy of gene therapies is developed and test. However, it was first important to characterize the neuropathological changes that occur with disease progression in affected sheep. This
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Ten-m4 plays a unique role in the establishment of binocular visual circuits Dev. Neurobiol. (IF 3.0) Pub Date : 2023-04-24 Timothy R. Young, Dylan Black, Hannan Mansuri, Toshitaka Oohashi, Xiao-Hong Zhou, Atomu Sawatari, Catherine A. Leamey
The patterning of binocular vision requires distinct molecular pathways for inputs arising from each side of the nervous system. Recent studies have demonstrated important roles for members of the Ten-m/Odz/teneurin family in the development of ipsilateral retinal projections. Here, we further highlight the significance of this gene family in visual development by identifying a role for Ten-m4 during
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Ccdc25 regulates neurogenesis during the brain development Dev. Neurobiol. (IF 3.0) Pub Date : 2023-04-24 Chong Wang, Jie Qin, Jianwei Jiao, Fen Ji
During brain development, the proliferation and differentiation of neural stem cells (NSCs) are precisely regulated. Defects in embryonic brain development can lead to serious developmental disorders. The cerebral cortex is the most evolved and complicated structure in the mammalian brain. The process of neuronal production, also known as neurogenesis, plays crucial roles in cerebral development and
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Advances in in utero electroporation Dev. Neurobiol. (IF 3.0) Pub Date : 2023-03-02 Claire M. Kittock, Louis-Jan Pilaz
In utero electroporation (IUE) is a technique developed in the early 2000s to transfect the neurons and neural progenitors of embryonic brains, thus enabling continued development in utero and subsequent analyses of neural development. Early IUE experiments focused on ectopic expression of plasmid DNA to analyze parameters such as neuron morphology and migration. Recent advances made in other fields
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Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response Dev. Neurobiol. (IF 3.0) Pub Date : 2023-02-16 Virginie Petel Légaré, Christian J. Rampal, Tyler J. N. Gurberg, Mari J. Aaltonen, Alexandre Janer, Lorne Zinman, Eric A. Shoubridge, Gary A. B. Armstrong
Mutations in CHCHD10 and CHCHD2, encoding two paralogous mitochondrial proteins, have been identified in cases of amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Parkinson's disease. Their role in disease is unclear, though both have been linked to mitochondrial respiration and mitochondrial stress responses. Here, we investigated the biological roles of these proteins during
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Excitatory and inhibitory neuron imbalance in the intrauterine growth restricted fetal guinea pig brain: Relevance to the developmental origins of schizophrenia and autism Dev. Neurobiol. (IF 3.0) Pub Date : 2022-11-14 Angela Cumberland, Nadia Hale, Aminath Azhan, Courtney P. Gilchrist, Ginevra Chincarini, Mary Tolcos
Neurodevelopmental disorders such as schizophrenia and autism are thought to involve an imbalance of excitatory and inhibitory signaling in the brain. Intrauterine growth restriction (IUGR) is a risk factor for these disorders, with IUGR onset occurring during critical periods of neurodevelopment. The aim of this study was to determine the impact of IUGR on excitatory and inhibitory neurons of the
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microRNA-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development Dev. Neurobiol. (IF 3.0) Pub Date : 2022-11-07 Kalin D. Konrad, Jia L. Song
MicroRNAs regulate gene expression by destabilizing target mRNA and/or inhibiting translation in animal cells. The ability to mechanistically dissect miR-124′s function during specification, differentiation, and maturation of neurons during development within a single system has not been accomplished. Using the sea urchin embryo, we take advantage of the manipulability of the embryo and its well-documented
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Family income buffers the relationship between childhood adverse experiences and putamen volume Dev. Neurobiol. (IF 3.0) Pub Date : 2022-10-31 Max P. Herzberg, Laura Hennefield, Katherine R. Luking, Ashley F. P. Sanders, Alecia C. Vogel, Sridhar Kandala, Rebecca Tillman, Joan Luby, Deanna M. Barch
Adverse experiences and family income in childhood have been associated with altered brain development. While there is a large body of research examining these associations, it has primarily used cross-sectional data sources and studied adverse experiences and family income in isolation. However, it is possible that low family income and adverse experiences represent dissociable and potentially interacting
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Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622 Dev. Neurobiol. (IF 3.0) Pub Date : 2022-10-29 Andrew J. Riquier, Suzanne I. Sollars
Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) of the rat are a prime example of developmental pruning, undergoing an approximate 66% reduction in volume from postnatal day 15 (P15) to P25. Later in adulthood
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Microglia in motor neuron disease: Signaling evidence from last 10 years Dev. Neurobiol. (IF 3.0) Pub Date : 2022-10-29 Min-Jia Wang, Lu Kang, Yao-Zheng Wang, Bi-Ru Yang, Chun Zhang, Yu-Feng Lu, Liang Kang
Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators are associated with microglia, such as fractalkine signaling, purinergic signaling, NF-κB signaling
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Large-scale waves of activity in the neonatal mouse brain in vivo occur almost exclusively during sleep cycles Dev. Neurobiol. (IF 3.0) Pub Date : 2022-10-17 Dennis R. Tabuena, Randy Huynh, Jenna Metcalf, Thomas Richner, Albrecht Stroh, Bingni W. Brunton, William J. Moody, Curtis R. Easton
Spontaneous electrical activity plays major roles in the development of cortical circuitry. This activity can occur highly localized regions or can propagate over the entire cortex. Both types of activity coexist during early development. To investigate how different forms of spontaneous activity might be temporally segregated, we used wide-field trans-cranial calcium imaging over an entire hemisphere
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Sex differences in myelination of the zebra finch vocal control system emerge relatively late in development Dev. Neurobiol. (IF 3.0) Pub Date : 2022-10-07 Adriana Diez, Shenghan Wang, Nicole Carfagnini, Scott A. MacDougall-Shackleton
The role of myelination in the development of motor control is widely known, but its role in the development of cognitive abilities is less understood. Here, we examined sex differences in the development of myelination of structures and tracts that support song learning and production in songbirds. We collected brains from 63 young male and female zebra finches (Taeniopygia guttata) over four stages
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The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX Dev. Neurobiol. (IF 3.0) Pub Date : 2022-09-06 Alessia Caramello, Christophe Galichet, Miriam Llorian Sopena, Robin Lovell-Badge, Karine Rizzoti
The adult dentate gyrus (DG) of rodents hosts a neural stem cell (NSC) niche capable of generating new neurons throughout life. The embryonic origin and molecular mechanisms underlying formation of DG NSCs are still being investigated. We performed a bulk transcriptomic analysis on mouse developing archicortex conditionally deleted for Sox9, a SoxE transcription factor controlling both gliogenesis
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Enriched environment rescues neonatal pain induced cognitive deficits and the impaired hippocampal synaptic plasticity later in life Dev. Neurobiol. (IF 3.0) Pub Date : 2022-08-09 Cuiting Min, Ru Ling, Mengying Chen, Dongqing Xia, Ran Chen, Xiaonan Li
Although extensive and untreated pain that occurs during a critical developmental window may impair cognition later in life, environmental interventions early in life might promote cognition. However, the underlying mechanism is poorly understood. Our current study utilized a rat model of “repetitive needle pricks” from the day of birth (P0) to postnatal day 7 (P7) to mimic the painful experience of
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Corticogenesis across species at single-cell resolution Dev. Neurobiol. (IF 3.0) Pub Date : 2022-08-06 Seon Hye E. Park, Ana K. Ortiz, Genevieve Konopka
The neocortex (or pallium) consists of diverse cell types that are organized in a highly species-specific manner under strict spatiotemporal control during development. Many of the cell types are present transiently throughout development but contribute to permanent species-specific cortical features that are acquired through evolution. Therefore, capturing cell type-specific biological information
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CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain Dev. Neurobiol. (IF 3.0) Pub Date : 2022-08-05 Youjia Guo, Carolina Fiallos Oliveros, Toshio Ohshima
Axonal connections between the two sides of the brain are essential for processing sensorimotor functions, especially in animals with bilateral symmetry. The anterior commissure and postoptic commissure are two crucial axonal projections that develop early in the zebrafish central nervous system. In this study, we characterized the function of collapsin response mediator protein 2 (CRMP2) and CRMP4
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Dachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expression Dev. Neurobiol. (IF 3.0) Pub Date : 2022-07-07 Luis Clarembaux-Badell, Pablo Baladrón-de-Juan, Hugo Gabilondo, Irene Rubio-Ferrera, Irene Millán, Carlos Estella, Félix S. Valverde-Ortega, Ignacio Monedero Cobeta, Stefan Thor, Jonathan Benito-Sipos
A striking feature of the nervous system pertains to the appearance of different neural cell subtypes at different axial levels. Studies in the Drosophila central nervous system reveal that one mechanism underlying such segmental differences pertains to the segment-specific removal of cells by programmed cell death (PCD). One group of genes involved in segment-specific PCD is the Hox homeotic genes
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Modulation of calcineurin signaling during development Dev. Neurobiol. (IF 3.0) Pub Date : 2022-07-03 Sara Tucker Edmister, Robbert Creton
Calcineurin signaling pathways are suppressed in Down syndrome (trisomy 21), by overexpression of genes that are located on chromosome 21. Two key genes are the regulator of calcineurin 1 (RCAN1), also called the Down syndrome critical region 1 (DSCR1), and the dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). The suppressed calcineurin pathway may potentially be restored using
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Evolutionary innovations of human cerebral cortex viewed through the lens of high-throughput sequencing Dev. Neurobiol. (IF 3.0) Pub Date : 2022-06-28 Ikuo K. Suzuki
Humans had acquired a tremendously enlarged cerebral cortex containing a huge quantity and variety of cells during evolution. Such evolutionary uniqueness offers a neural basis of our cognitive innovation and human-specific features of neurodevelopmental and psychiatric disorders. Since human brain is hardly examined in vivo with experimental approaches commonly applied on animal models, the recent
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The role of snare proteins in cortical development Dev. Neurobiol. (IF 3.0) Pub Date : 2022-06-20 Auguste Vadisiute, Elise Meijer, Florina Szabó, Anna Hoerder-Suabedissen, Eri Kawashita, Shuichi Hayashi, Zoltán Molnár
Neural communication in the adult nervous system is mediated primarily through chemical synapses, where action potentials elicit Ca2+ signals, which trigger vesicular fusion and neurotransmitter release in the presynaptic compartment. At early stages of development, the brain is shaped by communication via trophic factors and other extracellular signaling, and by contact-mediated cell–cell interactions
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Evolution of genetic mechanisms regulating cortical neurogenesis Dev. Neurobiol. (IF 3.0) Pub Date : 2022-06-07 Alexandre Espinós, Eduardo Fernández-Ortuño, Enrico Negri, Víctor Borrell
The size of the cerebral cortex increases dramatically across amniotes, from reptiles to great apes. This is primarily due to different numbers of neurons and glial cells produced during embryonic development. The evolutionary expansion of cortical neurogenesis was linked to changes in neural stem and progenitor cells, which acquired increased capacity of self-amplification and neuron production. Evolution
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Evaluation of advances in cortical development using model systems Dev. Neurobiol. (IF 3.0) Pub Date : 2022-05-29 Patricia R. Nano, Aparna Bhaduri
Compared with that of even the closest primates, the human cortex displays a high degree of specialization and expansion that largely emerges developmentally. Although decades of research in the mouse and other model systems has revealed core tenets of cortical development that are well preserved across mammalian species, small deviations in transcription factor expression, novel cell types in primates
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Transcriptomic analyses of NeuroD1-mediated astrocyte-to-neuron conversion Dev. Neurobiol. (IF 3.0) Pub Date : 2022-05-23 Ning-Xin Ma, Brendan Puls, Gong Chen
Ectopic expression of a single neural transcription factor NeuroD1 can reprogram reactive glial cells into functional neurons both in vitro and in vivo, but the underlying mechanisms are not well understood yet. Here, we used RNA-sequencing technology to capture the transcriptomic changes at different time points during the reprogramming process. We found that following NeuroD1 overexpression, astroglial
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In vivo glia-to-neuron conversion: pitfalls and solutions Dev. Neurobiol. (IF 3.0) Pub Date : 2022-05-10 Lei-Lei Wang, Chun-Li Zhang
Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia-to-neuron (GtN) conversion emerges as a potential solution for regeneration-based therapeutics. This approach takes advantage of the regenerative ability of resident glial cells to produce new neurons through cell
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E3 ubiquitin ligases and cerebral cortex development in health and disease Dev. Neurobiol. (IF 3.0) Pub Date : 2022-04-27 Nicolas Lambert, Martin Moïse, Laurent Nguyen
Cerebral cortex development involves the sequential progression of biological steps driven by molecular pathways whose tight regulation often relies on ubiquitination. Ubiquitination is a posttranslational modification involved in all aspects of cellular homeostasis through the attachment of a ubiquitin (Ub) moiety on proteins. Over the past years, an increasing amount of research has highlighted the
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Characterization of neurological disease progression in a canine model of CLN5 neuronal ceroid lipofuscinosis Dev. Neurobiol. (IF 3.0) Pub Date : 2022-04-15 Elizabeth J. Meiman, Grace Robinson Kick, Cheryl A. Jensen, Joan R. Coates, Martin L. Katz
Golden Retriever dogs with a frameshift variant in CLN5 (c.934_935delAG) suffer from a progressive neurodegenerative disorder analogous to the CLN5 form of neuronal ceroid lipofuscinosis (NCL). Five littermate puppies homozygous for the deletion allele were identified prior to the onset of disease signs. Studies were performed to characterize the onset and progression of the disease in these dogs.
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Refinement of axonal conduction and myelination in the mouse optic nerve indicate an extended period of postnatal developmental plasticity Dev. Neurobiol. (IF 3.0) Pub Date : 2022-04-11 Annika Balraj, Cheryl Clarkson-Paredes, Ahdeah Pajoohesh-Ganji, Matthew W. Kay, David Mendelowitz, Robert H. Miller
Retinal ganglion cells generate a pattern of action potentials to communicate visual information from the retina to cortical areas. Myelin, an insulating sheath, wraps axonal segments to facilitate signal propagation and when deficient, can impair visual function. Optic nerve development and initial myelination has largely been considered completed by the fifth postnatal week. However, the relationship
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Polycomb-mediated gene regulation in human brain development and neurodevelopmental disorders Dev. Neurobiol. (IF 3.0) Pub Date : 2022-04-05 Nora Bölicke, Mareike Albert
The neocortex is considered the seat of higher cognitive function in humans. It develops from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This process of cell fate determination is controlled by precise temporal and spatial gene expression patterns that in turn are affected by epigenetic mechanisms including Polycomb group (PcG) regulation. PcG proteins assemble
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Cortical myelination in toddlers and preschoolers with autism spectrum disorder Dev. Neurobiol. (IF 3.0) Pub Date : 2022-03-29 Bosi Chen, Annika Linke, Lindsay Olson, Jiwandeep Kohli, Mikaela Kinnear, Martin Sereno, Ralph-Axel Müller, Ruth Carper, Inna Fishman
Intracortical myelin is thought to play a significant role in the development of neural circuits and functional networks, with consistent evidence of atypical network connectivity in children with autism spectrum disorder (ASD). However, little is known about the development of intracortical myelin in the first years of life in ASD, during the critical neurodevelopmental period when autism symptoms
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Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance Dev. Neurobiol. (IF 3.0) Pub Date : 2022-03-25 Yue Qu, Juliana Alves-Silva, Kriti Gupta, Ines Hahn, Jill Parkin, Natalia Sánchez-Soriano, Andreas Prokop
Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require loose microtubule bundles that extend through their entire length. Understanding microtubule regulation is therefore an essential aspect of axon biology. Key regulators of neuronal microtubules are the spectraplakins, a well-conserved family
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Cortical surface variation in individuals with excessive smartphone use Dev. Neurobiol. (IF 3.0) Pub Date : 2022-03-25 Dusan Hirjak, Gudrun M. Henemann, Mike M. Schmitgen, Larissa Götz, Nadine D. Wolf, Katharina M. Kubera, Fabio Sambataro, Tagrid Leménager, Julian Koenig, Robert Christian Wolf
Excessive smartphone use has been repeatedly related to adverse effects on mental health and psychological well-being in young adults. The continued investigation of the neurobiological mechanism underlying excessive smartphone use—sometimes also referred to as “smartphone addiction”(SPA)—is considered a top priority in system neuroscience research. Despite progress in the past years, cortical morphology
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Developmental neural activity requires neuron–astrocyte interactions Dev. Neurobiol. (IF 3.0) Pub Date : 2022-02-28 Bryce T. Bajar, Nguyen T. Phi, Harpreet Randhawa, Orkun Akin
Developmental neural activity is a common feature of neural circuit assembly. Although glia have established roles in synapse development, the contribution of neuron–glia interactions to developmental activity remains largely unexplored. Here we show that astrocytes are necessary for developmental activity during synaptogenesis in Drosophila. Using wide-field epifluorescence and two-photon imaging
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Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development Dev. Neurobiol. (IF 3.0) Pub Date : 2022-02-26 Yugo Ishino, Shoko Shimizu, Masaya Tohyama, Shingo Miyata
Protein arginine methylation has been recognized as one of key posttranslational modifications for refined protein functions, mediated by protein arginine methyltransferases (Prmts). Coactivator-associated arginine methyltransferase (Carm1, also known as Prmt4) participates in various cellular events, such as cell survival, proliferation, and differentiation through its protein arginine methylation
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Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain Dev. Neurobiol. (IF 3.0) Pub Date : 2022-02-26 Scott A. Love, Emmanuelle Haslin, Manon Bellardie, Frédéric Andersson, Laurent Barantin, Isabelle Filipiak, Hans Adriaensen, Csilla L. Fazekas, Laurène Leroy, Dóra Zelena, Mélody Morisse, Frédéric Elleboudt, Christian Moussu, Frédéric Lévy, Raymond Nowak, Elodie Chaillou
The psychoendocrine evaluation of lamb development has demonstrated that maternal deprivation and milk replacement alters health, behavior, and endocrine profiles. While lambs are able to discriminate familiar and non-familiar conspecifics (mother or lamb), only lambs reared with their mother develop such clear social discrimination or preference. Lambs reared without mother display no preference for
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Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish Dev. Neurobiol. (IF 3.0) Pub Date : 2022-02-25 Bhagyashri Joshi, Himanshu Gaur, Subhra Prakash Hui, Chinmoy Patra
The Cadherin EGF LAG seven-pass G-type receptor (Celsr) family belongs to the adhesion G-protein coupled receptor superfamily. In most vertebrates, the Celsr family has three members (CELSR1–3), whereas zebrafish display four paralogues (celsr1a, 1b, 2, 3). Although studies have shown the importance of the Celsr family in planar cell polarity, axonal guidance, and dendritic growth, the molecular mechanisms
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Oligodendrocytes and myelin: Active players in neurodegenerative brains? Dev. Neurobiol. (IF 3.0) Pub Date : 2022-01-26 Jing-Fei Chen, Fei Wang, Nan-Xing Huang, Lan Xiao, Feng Mei
Oligodendrocytes (OLs) are a major type of glial cells in the central nervous system that generate multiple myelin sheaths to wrap axons. Myelin ensures fast and efficient propagation of action potentials along axons and supports neurons with nourishment. The decay of OLs and myelin has been implicated in age-related neurodegenerative diseases and these changes are generally considered as an inevitable
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Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output Dev. Neurobiol. (IF 3.0) Pub Date : 2022-01-11 Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F. Fregosi
Serotonin plays an important role in the development of brainstem circuits that control breathing. Here, we test the hypothesis that developmental nicotine exposure (DNE) alters the breathing-related motor response to serotonin (5HT). Pregnant rats were exposed to nicotine or saline, and brainstem–spinal cord preparations from 1- to 5-day-old pups were studied in a split-bath configuration, allowing
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Origin, molecular specification, and stemness of astrocytes Dev. Neurobiol. (IF 3.0) Pub Date : 2022-01-10 Kang Zheng, Hao Huang, Junlin Yang, Mengsheng Qiu
Astrocytes are the most abundant cell type in the central nervous system, carrying out a wide spectrum of biological functions. During early development, neural progenitor cells in the ventricular zone first produce neurons, followed by macroglia in the form of astrocytes or oligodendrocytes. Although the lineage progression of oligodendrocytes has been well understood, the developmental staging of
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Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4 Dev. Neurobiol. (IF 3.0) Pub Date : 2021-12-21 Yurika Nakanishi, Satoshi Akinaga, Koki Osawa, Natusmi Suzuki, Ayaka Sugeno, Papachan Kolattukudy, Yoshio Goshima, Toshio Ohshima
Axon pruning facilitates the removal of ectopic and misguided axons and plays an important role in neural circuit formation during brain development. Sema3F and its receptor neuropilin-2 (Nrp2) have been shown to be involved in the stereotyped pruning of the infrapyramidal bundle (IPB) of mossy fibers of the dentate gyrus (DG) in the developing hippocampus.
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The origin and repopulation of microglia Dev. Neurobiol. (IF 3.0) Pub Date : 2021-12-07 Lijuan Zhang, Yue Cao, Xin Zhang, Xinyang Gu, Ying Mao, Bo Peng
Microglia are important immune cells in the central nervous system. There is growing interest in the study of microglia due to their implication in neurodevelopment, acute injury, and neuropsychiatric disorders. They undergo birth, death, and regeneration during the lifetime. Although data on the ontogeny of microglia have been studied for decades, the birth and repopulation of microglia remain legendary
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Microglial TREM2 in amyotrophic lateral sclerosis Dev. Neurobiol. (IF 3.0) Pub Date : 2021-12-07 Manling Xie, Shunyi Zhao, Dale B. Bosco, Aivi Nguyen, Long-Jun Wu
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is an aggressive motor neuron degenerative disease characterized by selective loss of both upper and lower motor neurons. The mechanisms underlying disease initiation and progression are poorly understood. The involvement of nonmotor neuraxis emphasizes the contribution of glial cells in disease progress. Microglia comprise a
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Effect of lncRNA H19 on nerve degeneration and regeneration after sciatic nerve injury in rats Dev. Neurobiol. (IF 3.0) Pub Date : 2021-11-24 Yuting Li, Min Cai, Yumei Feng, Bryant Yung, Yi Wang, Nannan Gao, Xi Xu, Huanhuan Zhang, Huiwei Huang, Dengbing Yao
Hundreds of millions of people worldwide suffer from peripheral nerve damage resulting from car accidents, falls, industrial accidents, residential accidents, and wars. The purpose of our study was to further investigate the effects of Wallerian degeneration (WD) after rat sciatic nerve injury and to screen for critical long noncoding RNAs (lncRNAs) in WD. We found H19 to be essential for nerve degeneration
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Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis Dev. Neurobiol. (IF 3.0) Pub Date : 2021-11-14 Song-Qun Hu, Hui-Min Xu, Fu-Ping Qian, Chang-Sheng Chen, Xin Wang, Dong Liu, Lei Cheng
Interferon regulatory factor-7 (IRF7) is an essential regulator of both innate and adaptive immunity. It is also expressed in the otic vesicle of zebrafish embryos. However, any role for irf7 in hair cell development was uncharacterized. Does it work as a potential deaf gene to regulate hair cell development? We used whole-mount in situ hybridization (WISH) assay and morpholino-mediated gene knockdown