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Perceived and Self-Stigma in People with Epilepsy in East Africa: Systematic Review and Meta-analysis Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-03-11 Techilo Tinsae, Shegaye Shumet, Girmaw Medifu, Gidey Eriteby, Setegn Fentahun, Wondale Getinet
People with stigmatizing conditions associated with epilepsy encounter many difficulties in their daily lives and are more likely to have low self-esteem, low levels of hope, internalize negative attitudes, decrease adherence to treatment, and experience unemployment. The purpose of this study was to quantify the extent of perceived stigma and self-stigma among people with epilepsy. This systematic
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Predictors of medical intractability in children with epilepsy onset during the first two years of life, excluding infantile epileptic spasm syndrome Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-03-09 Miraç Yıldırım, Mert Altıntaş, Ece Uysal, Ömer Bektaş, Serap Teber
Early childhood epilepsy presents a significant challenge, with approximately 30 % of individuals experiencing treatment failure. This study aimed to identify predictors of medical intractability in children with epilepsy onset during the first two years of life, excluding infantile epileptic spasm syndrome. A total of 323 children were retrospectively evaluated. The analyses included a review of medical
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Teratogenicity of zonisamide and other little-used antiseizure medications Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-03-02 Frank J.E. Vajda, Terence J. O'Brien, Janet E. Graham, Alison A. Hitchcock, Piero Perucca, Cecilie M. Lander, Mervyn J. Eadie
To investigate the risk of teratogenesis occurring in relation to intrauterine exposure to infrequently used antiseizure medications in Australia. Analysis of data contained in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs. There was statistically significant evidence that zonisamide, but not any other of nine infrequently used antiseizure medications in Australia, was associated
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Neurostimulation targeting the epileptic focus: Current understanding and perspectives for treatment Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-03-02 Andreas Schulze-Bonhage, Michael A. Nitsche, Stefan Rotter, Niels K. Focke, Vikram R. Rao
For the one third of people with epilepsy whose seizures are not controlled with medications, targeting the seizure focus with neurostimulation can be an effective therapeutic strategy. In this focused review, we summarize a discussion of targeted neurostimulation modalities during a workshop held in Frankfurt, Germany in September 2023. Topics covered include: available devices for seizure focus stimulation;
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Psychiatric assessment prior to and after switch from levetiracetam to brivaracetam Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-02-29 Ammar Kassoum, Tassanai Intravooth, Anne-Sophie Wendling, Anke M. Staack, Bernhard J. Steinhoff
Brivaracetam is often used as an alternative to levetiracetam in patients with epilepsy (PWE) encountering efficacy issues or adverse events with levetiracetam. This study evaluated the psychological status of PWE who were switched from levetiracetam to brivaracetam due to psychiatric tolerability concerns in comparison to those who remained on levetiracetam. We used various psychological assessments
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A challenging case of epilepsy in infancy with migrating focal seizures due to a de novo KCNT1 missense variant (c.1438G>A, p.Asp480Asn) Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-02-29 Moisés León-Ruiz, Pablo Alonso-Singer, Milagros Merino-Andreu, Carlos Castañeda-Cabrero
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Comparison of neurodevelopmental, educational and adult socioeconomic outcomes in offspring of women with and without epilepsy: A systematic review and meta-analysis Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-02-29 Paolo Pierino Mazzone, Kirsty Mhairi Hogg, Christopher J. Weir, Jacqueline Stephen, Sohinee Bhattacharya, Simone Richer, Richard F.M. Chin
Adequate pre-pregnancy counselling and education planning are essential to improve outcomes for offspring of women with epilepsy (OWWE). The current systematic review and meta-analysis aimed to compare outcomes for OWWE and offspring of women without epilepsy (OWWoE). We conducted a systematic review and meta-analysis. We searched MEDLINE, EMBASE, CINAHL, PsycINFO (database inception-1 January 2023)
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Functional brain connectivity in children with focal epilepsy: A systematic review of functional MRI studies Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-02-28 Xiyu Feng, Rory J. Piper, Freya Prentice, Jonathan D. Clayden, Torsten Baldeweg
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Diagnosis and management of infantile epileptic spasms syndrome (IESS) in Gulf Cooperation Council (GCC) countries: Expert consensus statement Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-02-23 Fahad A. Bashiri, Khalid Hundallah, Raidah Al-Baradie, Ali Al-Otaibi, Omar Ismayl, Mohamed Elhadi AlMalik, Osama Y. Muthaffar, Amna Al Futaisi, Daniah Kurdi, Asmaa Al Tawari, Daad AlSowat, Shatha AL Shafi, Ayman Ali, Lynn M. AlHajjar, Abdullah Aldakhil
Despite the availability of international recommendations for the management of Infantile Epileptic Spasms Syndrome (IESS), there is a lack of recommendations adapted to the local context of clinical practice of pediatric neurology in the Gulf Cooperation Council (GCC) countries. By an initiative from the Saudi Pediatric Neurology Society (SPNS), a literature review was performed and an expert panel
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An atypical case of phosphoglycerate kinase deficiency with a novel PGK1 variant Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2024-02-20 Xizhong Zhou, Qiuli Liu, Mingwei Huang
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Bilateral and synchronous "dents de scie" spikes: A highly specific EEG pattern of young adult Dravet syndrome. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-25 Philippe Gélisse,Pierre Genton,Arielle Crespel
BACKGROUND In Dravet syndrome (DS), EEGs evolve over time. OBJECTIVE To describe a peculiar EEG pattern in two adults with a de novo SCN1A gene mutation, in exon 5 (case 1) and 9 (case 2). METHODS Two female patients underwent a prolonged video EEG (24 h) as part of their epilepsy assessment. RESULTS In both cases, the EEG showed a very peculiar and stereotypical pattern of bilateral synchronous spikes
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Interpretable machine learning models for predicting 90-day death in patients in the intensive care unit with epilepsy. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-25 Yingfang She,Liemin Zhou,Yide Li
PURPOSE This study aims to develop a machine learning-based model for predicting mortality risk in patients with epilepsy admitted to the intensive care unit (ICU), providing clinicians with an accurate prognostic tool to guide individualized treatment. METHODS We collected clinical data from clinical databases (MIMIC IV and eICU-CRD) of epilepsy patients 24 h after ICU admission. The clinical characteristics
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Assessing the performance of ChatGPT's responses to questions related to epilepsy: A cross-sectional study on natural language processing and medical information retrieval. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-23 Hyun-Woo Kim,Dong-Hyeon Shin,Jiyoung Kim,Gha-Hyun Lee,Jae Wook Cho
BACKGROUND Epilepsy is a neurological condition marked by frequent seizures and various cognitive and psychological effects. Reliable information is essential for effective treatment. Natural language processing models like ChatGPT are increasingly used in healthcare for information access and data analysis, making it crucial to assess their accuracy. OBJECTIVE This study aimed to investigate the accuracy
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Normalization and cross-sectional validation of an extended Adverse Event Profile (E AEP) in a large cohort of patients with epilepsy. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-22 Christoph Helmstaedter,Carolin Meschede,Sandra Mastani,Susanna Moskau-Hartmann,Michael Rademacher,Randi von Wrede,Juri-Alexander Witt
PURPOSE The Liverpool Adverse Event Profile (L AEP) is commonly applied in clinical practice and pharmacological trials for the monitoring of side effects of anti-seizure medication (ASM). However, additional symptoms need to be assessed and normative data would be appreciated to put patients´ complaints into perspective. METHODS An extended 32-item AEP (E AEP) was given to 537 healthy subjects and
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Predictors of elevations in fasting lipid levels in adults with epilepsy on a modified Atkins diet. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-21 Tanya J W McDonald,Luisa Diaz-Arias,Diane Vizthum,Bobbie J Henry-Barron,Mackenzie C Cervenka
BACKGROUND Ketogenic diet therapies can improve seizure control in patients with drug-resistant epilepsy (DRE). The current study investigated whether dietary fat composition is associated with elevations in serum lipid levels in adults with epilepsy who began a modified Atkins diet (MAD). METHODS Adults with DRE were instructed to follow the MAD. Food records collected at baseline and follow-up were
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Clinician views regarding early surgery for paediatric epilepsy. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-20 Omar Salim,Aswin Chari,Ido Ben Zvi,Rachel Batchelor,Torsten Baldeweg,J Helen Cross,Martin Tisdall
OBJECTIVE Many children with lesional epilepsies progress to drug resistance, a criterion required for surgical referral. Expedited surgery may reduce exposure of the developing brain to uncontrolled seizures, improving cognitive outcomes. Designing a trial comparing early surgery with standard care necessitates input from specialist clinicians regarding feasibility and measurable outcomes, which this
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Peri-ictal water drinking with temporo-insular onset: A Stereoelectroencephalography (SEEG) case. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-13 Norah A AlKhaldi,Poul Espino Alvarado,Jorge G Burneo,Keith Macdougall,Brent Hayman-Abello,Ana Suller Marti
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The promises and pitfalls of seizure phenomenology. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-11 Alistair Wardrope
The typical adult patient presenting with a first seizure has a normal clinical examination, uninformative investigations, and often has no witness to their episode. The assessing clinician, therefore, has one primary source of information to guide their assessment; the patient's experience. However, seizure phenomenology - the subjective seizure experience - has received relatively less attention
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Role of magnetoencephalography in predicting the epileptogenic zone and post-operative seizure outcome - A retrospective study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-11 Dodmalur Mallikarjuna Sindhu,Ravindranadh Chowdary Mundlamuri,Bhargava Goutham,Mariyappa Narayanan,Kenchaiah Raghavendra,Ajay Asranna,Lakshminarayanapuram Gopal Vishwanathan,Karthik Kulanthaivelu,Jitender Saini,Sandhya Mangalore,Rose Dawn Bharath,Nishanth Sadashiva,Anita Mahadevan,Rajeswaran Jamuna,Arimappamagan Arivazhagan,Malla Bhaskara Rao,Sanjib Sinha
PURPOSE Study assessed the role of MSI in predicting the post-operative seizure outcome. METHODS This retrospective study included patients who underwent MEG and epilepsy surgery and had a minimum 6 months of postoperative follow-up. Concordance of MEG cluster with post-surgical resection cavity was classified as follows Class I) Concordant and region-specific, Class II) Concordant and region non-specific
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Machine learning-based classification of physiological and pathological high-frequency oscillations recorded by stereoelectroencephalography. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-10 Zilin Li,Baotian Zhao,Wenhan Hu,Chao Zhang,Xiu Wang,Jianguo Zhang,Kai Zhang
OBJECTIVE High-frequency oscillations (HFOs) are an efficient indicator to locate the epileptogenic zone (EZ). However, physiological HFOs produced in the normal brain region may interfere with EZ localization. The present study aimed to build a machine learning-based classifier to distinguish the properties of each HFO event based on features in different domains. METHODS HFOs were detected in focal
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Developmental and epileptic encephalopathy 82 (DEE82) with novel compound heterozygous mutations of GOT2 gene. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-09 Özlem Yalçın Çapan,Dilşad Türkdoğan,Sertaç Atalay,Hande S Çağlayan
PURPOSE Developmental and Epileptic Encephalopathies (DEEs) are rare neurological disorders characterized by early-onset medically resistant epileptic seizures, structural brain malformations, and severe developmental delays. These disorders can arise from mutations in genes involved in vital metabolic pathways, including those within the brain. Recent studies have implicated defects in the mitochondrial
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Video-EEG in the first 24 hours after the first unprovoked seizure in patients with normal neurological examination and head CT scan. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-04 Virgilio Hernando-Requejo,Nuria Huertas-González,Clara Horcajo-Gómez,M Angeles Vilches-Martínez,Estefanía Cantador-Pavón,Maria Sastre-Real
PURPOSE to determine the yield of Video-Electroencephalogram (VEEG) in the first 24 h in patients with a first unprovoked seizure and normal neurological examination, laboratory findings, and cranial CT scans. METHODS we analyzed retrospectively the yield of VEEG performed in these patients in the emergency department. All the patients were subsequently seen in the Epilepsy Clinic, and the epilepsy
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Determinants of felt-stigma in adolescents with epilepsy: Is it the same story? Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-03 Nuran Aydemir,Özüm Karya Sakman,Şakir Delil,Çiğdem Özkara
PURPOSE The present study aimed to investigate previously researched variables in adult people with epilepsy (PWE), which include felt stigma, perceived overprotection, concealment of epilepsy, and epilepsy-related concerns for adolescents with epilepsy (AWE). Another goal was to determine the reported levels of these variables and explore the relationships among them, as well as their associations
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Exome analysis focusing on epilepsy-related genes in children and adults with sudden unexplained death. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-02 Sarah E Buerki,Cordula Haas,Jacqueline Neubauer
PURPOSE Genetic studies in sudden infant death syndrome (SIDS) and sudden unexplained death (SUD) cohorts have indicated that cardiovascular diseases might have contributed to sudden unexpected death in 20-35 % of autopsy-negative cases. Sudden unexpected death can also occur in people with epilepsy, termed as sudden unexpected death in epilepsy (SUDEP). The pathophysiological mechanisms of SUDEP are
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Prevalence and nature of patient-reported antiseizure medication side effects in a Swedish regional multi-center study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-11-02 Johan Zelano,Olha Nika,Fredrik Asztely,David Larsson,Klara Andersson,Kerstin Andrén
PURPOSE Side effects is one of the major clinical problems in epilepsy care. We assessed the prevalence of ASM side effects in participants in a large regional multicenter observational study in western Sweden and aimed to identify risk factors and inventory the nature of side effects with different ASM regimes. METHODS Cross-sectional analysis of survey answers and clinical characteristics of 406
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Advice following a possible first seizure: what do patients attending for EEG remember? Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-30 Orla McGonigle,Caoimh Russell,Yvonne Langan
PURPOSE This study was designed to assess the knowledge of patients following their first seizure or blackout of unknown cause. We aimed to compare the advice our cohort of patients recalled against that suggested in the current literature. BACKGROUND 5 % of the population will experience a non- febrile seizure in their lifetime. Education and advice for the patient and their family is an important
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Seizures at stroke onset: A case-control study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-29 Ji-Won Kim,Henning R Stetefeld,Gereon R Fink,Michael P Malter
PURPOSE Seizures occurring at the immediate onset of a stroke, abbreviated "seizures at onset" (SaO), pose a diagnostic and therapeutic challenge for physicians. In this study, we report on the current clinical practice in managing stroke patients with SaO from a large tertiary stroke center in Germany. METHODS We selected all patients with SaO and acute ischemic or hemorrhagic stroke admitted to the
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DYNC1H1 variants associated with infant-onset epilepsy without neurodevelopmental disorders. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-27 Wu-Chen Wu,Xiao-Yu Liang,Dong-Ming Zhang,Liang Jin,Zhi-Gang Liu,Xiao-Lu Zeng,Qiong-Xiang Zhai,Wei-Ping Liao,Na He,Xiang-Hong Meng
OBJECTIVES The DYNC1H1 variants are associated with abnormal brain morphology and neuromuscular disorders that are accompanied by epilepsy. This study aimed to explore the relationship between DYNC1H1 variants and epilepsy. MATERIALS AND METHODS Trios-based whole-exome sequencing was performed on patients with epilepsy. Previously reported epilepsy-related DYNC1H1 variants were systematically reviewed
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Myoclonic status epilepticus in non-progressive encephalopathies within the GRIN2A-associated epilepsy-aphasia spectrum. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-26 Adnan Deniz,Defne Alikılıç,Merve Öztürk,Ömer Karaca,Ayfer Sakarya Güneş,Bülent Kara
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A case of drug-resistant epilepsy and autism with de novo SLC6A8 gene variant. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-23 David Horvat,Matthew Kaminski,Yitao Ma
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SCAF4 variants are associated with epilepsy with neurodevelopmental disorders. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-21 Yuanyuan Hu,Bingbing Zhang,Li Chen,Jing He,Letian Yang,Xuqin Chen
AIMS The genetic causes of epilepsy with unknown etiology in most patients remain unknown. The aim of this study was to elucidate the phenotype of SCAF4-related epilepsy. METHODS Trio-based whole-exome sequencing was performed in patients with epilepsy. Silico programs and protein modeling were employed to predict the damaging of variants. Previously reported SCAF4 variants were systematically reviewed
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Reply to Letter to the Editor regarding our report titled Incidence, severity and outcomes of COVID-19 in age and gender matched adults with and without epilepsy in Moscow: A historical cohort study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-19 Flora Rider,W Allen Hauser,Alexander Yakovlev,Alexander Shpak,Alla Guekht
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Reduced total number of enlarged perivascular spaces in post-traumatic epilepsy patients with unilateral lesions - a feasibility study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-13 Gernot Hlauschek,Morten I Lossius,Daniel L Schwartz,Lisa C Silbert,Amelia J Hicks,Jennie L Ponsford,Lucy Vivash,Benjamin Sinclair,Patrick Kwan,Terrence J O'Brien,Sandy R Shultz,Meng Law,Gershon Spitz
BACKGROUND We investigated the value of automated enlarged perivascular spaces (ePVS) quantification to distinguish chronic traumatic brain injury (TBI) patients with post-traumatic epilepsy (PTE+) from chronic TBI patients without PTE (PTE-) in a feasibility study. METHODS Patients with and without PTE were recruited and underwent an MRI post-TBI. Multimodal auto identification of ePVS algorithm was
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Evolution of antiseizure medication use and cost in the United States of America 2006-2021. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-10 Iván Sánchez Fernández,Marina Gaínza-Lein,Marta Amengual-Gual,Cristina Barcia Aguilar,Amanda Romeu,Alcy Torres,Rinat Jonas,Laurie M Douglass
OBJECTIVE To describe the evolution in use and cost of antiseizure medications (ASM) in the United States of America (USA). METHODS Retrospective descriptive study using the IBM MarketScan Commercial Database (data of privately-insured patients) for the years 2006 to 2021. We identified patients with epilepsy who were on ASM. We adjusted cost for inflation with the Gross Domestic Product Implicit Price
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Familial occipital lobe epilepsy associated with GABAA receptor variants. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-05 Joana Fonte,Gonçalo Videira,Rui Chorão,Joel Freitas,Inês Carrilho,João Parente Freixo,Jorge Oliveira,João Chaves
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Drug-resistant focal epilepsy in a girl with SETD5-related intellectual disability. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-03 Ranjith Kumar Manokaran,Ayako Ochi,Elizabeth Kerr,Gregory Costain,Olivia Moran,Hiroshi Otsubo,Robyn Whitney,Puneet Jain
None.
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Healthcare providers' perspectives on stigma when working with people with functional seizures. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-01 Tresan Samuels,Chrisma Pretorius
PURPOSE This study aimed to explore healthcare providers' (HCPs) perspectives and experiences of stigma when working with people with Functional Seizures (FS). Particular focus was given to understanding HCPs' experience and knowledge of FS, discovering the attitudes held by HCPs towards working with FS as a mental health condition, and exploring HCPs' views of how their stigma manifests towards people
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Prevalence and comparison of psychological trauma and stressors in functional seizure patients from a public and private hospital. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-10-01 Gabriele Vilyte,James Butler,Chrisma Pretorius
PURPOSE To date not much is known about the differences, if any, between patients with functional seizures (FS) from different socioeconomic backgrounds. We sought to compare the psychological stress and trauma profiles of patients with FS from a private and public hospital in Cape Town, South Africa. METHODS Only video-electroencephalography-confirmed patients with FS were eligible for the study.
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Seizures in Schuurs-Hoeijmakers syndrome patients may resolve spontaneously: A case report from China. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-29 Yun Wang,Guangshuang Lu,Yun Cheng,Jie Hu,Wu Yang
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Epidemiology of focal onset seizures in children aged >1 month to 4 years in Europe, United States, and Canada: A literature review. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-27 Susanne Schubert-Bast,Moninder Kaur,Lars Joeres,Nadia Foskett,Robert Roebling,Adam Strzelczyk
The present study aims to report the currently available epidemiology of focal onset seizures in children aged >1 month to 4 years with the help of a literature review. The terms 'seizure*' OR 'epilepsy' combined with pediatric and epidemiology terms were used to search Embase, PubMed, and Web of Science up to November 16, 2021. Due to the scarcity of epidemiology data on focal onset seizures, the
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Vagus nerve stimulation in refractory idiopathic generalised epilepsy: An Irish retrospective observational study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-26 Javier Peña-Ceballos,Patrick B Moloney,Antonio Valentin,Cara O'Donnell,Niamh Colleran,Brenda Liggan,Breege Staunton-Grufferty,Patricia Ennis,Roger Grogan,Gerard Mullins,Daniel J Costello,Colin P Doherty,Kieron J Sweeney,Hany El Naggar,Ronan D Kilbride,Peter Widdess-Walsh,Donncha O'Brien,Norman Delanty
OBJECTIVE Refractory idiopathic generalised epilepsy (IGE; also known as genetic generalised epilepsy) is a clinical challenge due to limited available therapeutic options. While vagus nerve stimulation (VNS) is approved as an adjunctive treatment for drug-resistant focal epilepsy, there is limited evidence supporting its efficacy for refractory IGE. METHODS We conducted a single-centre retrospective
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The history of motion photography to video electroencephalography in the study of functional seizures and related seizure disorders: The first 100 years. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-24 Richard Ho,Enrique J Carrazana
This historical note highlights pivotal events of technology progressing between the late 19th and the 20th century to capture functional seizures and other related seizure episodes. From Charcot's initial use of photography for his study of hysteria at the Salpêtrière to the development of cinematography by Muybridge and Marey to study motion to the initial use of video electroencephalography (vEEG)
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Epileptogenic zone in Broca's area is resectable under awake surgery in accordance with the hodotopic framework: A case report. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-21 Takahiro Suzuki,Tomotaka Ishizaki,Satoshi Maesawa,Miki Hashida,Manabu Mutoh,Yoshiki Ito,Takafumi Tanei,Ryuta Saito
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Incidence, severity and outcomes of COVID-19 in age and gender matched adults with and without epilepsy in Moscow: A historical cohort study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-18 Flora Rider,W Allen Hauser,Alexander Yakovlev,Alexander Shpak,Alla Guekht
OBJECTIVE We hypothesized that PWE have an increased risk to acquire COVID-19. This was a historical cohort study to determine COVID-19 incidence, severity, mortality and risk factors in adults with active epilepsy (PWE) compared to residents of Moscow without epilepsy matched by age, gender, and region of residence - Moscow Community Comparisons (MCC). METHODS Subjects were derived from a cohort of
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Real-world evidence on the use of cannabidiol for the treatment of drug resistant epilepsy not related to Lennox-Gastaut syndrome, Dravet syndrome or Tuberous Sclerosis Complex. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-17 Camilo Espinosa-Jovel,Sandra Riveros,Carlos Bolaños-Almeida,Mateo Ramírez Salazar,Leidy Ceballos Inga,Laura Guío
INTRODUCTION Highly purified cannabidiol (CBD) has a broad spectrum of action and could be useful for the treatment of drug resistant epilepsy regardless of etiology or syndrome. MATERIALS AND METHODS Multicenter retrospective study that evaluated the efficacy and safety of CBD for the treatment of drug resistant epilepsy of different etiologies in patients >2 years of age. RESULTS Seventy-eight patients
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Association between SCN1A polymorphism and risk of epilepsy in children: A systematic review and meta-analysis. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-17 Zhihong Zhou,Shuihua Wu,Xin Zou,Shuo Gu
Epilepsy is a common neurological disorder in children. Numerous studies have demonstrated the association between SCN1A polymorphisms and risk of epilepsy in adults, but their role in epilepsy in children has just gained traction and results have remained inconsistent. In this work, we performed a systematic review and meta-analysis to assess the association between SCN1A polymorphisms and risk for
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Risk factors for preoperative and postoperative seizures in patients with glioblastoma according to the 2021 World Health Organization classification. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-17 Anteneh M Feyissa,Sofia S Sanchez-Boluarte,Diogo Moniz-Garcia,Kaisorn L Chaichana,Wendy J Sherman,Brin E Freund,William O Tatum,Erik H Middlebrooks,Joseph I Sirven,Alfredo Quinones-Hinojosa
OBJECTIVE To identify risk factors for developing glioblastoma (GBM) related preoperative (PRS) and postoperative seizures (POS). Also, we aimed to analyze the impact of PRS and POS on survival in a GBM cohort according to the revised 2021 WHO glioma classification. METHODS We performed a single-center retrospective cohort study of patients with GBM (according to the 2021 World Health Organization
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Status epilepticus in patients with glioblastoma: Clinical characteristics, risk factors, and epileptological outcome. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-16 Jenny Stritzelberger,Anna Gesmann,Imke Fuhrmann,Stefanie Balk,Caroline Reindl,Dominik Madžar,Martin Uhl,Tamara M Welte,Sebastian Brandner,Felix Eisenhut,Arnd Dörfler,Roland Coras,Werner Adler,Stefan Schwab,Florian Putz,Rainer Fietkau,Luitpold Distel,Hajo M Hamer
PURPOSE Epilepsy is a common comorbidity in patients with glioblastoma, however, clinical data on status epilepticus (SE) in these patients is sparse. We aimed to investigate the risk factors associated with the occurrence and adverse outcomes of SE in glioblastoma patients. METHODS We retrospectively analysed electronic medical records of patients with de-novo glioblastoma treated at our institution
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The evolution of epilepsy surgery in tuberous sclerosis in Sweden: A national registry study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-16 Kevin Pearsson,Erik A Eklund,Olof Rask,Ingmar Rosén,Håkan Sjunnesson,Maria Compagno-Strandberg
PURPOSE This study aimed to characterize the Swedish cohort of surgically treated patients with TSC and explore differences in preoperative investigation and outcome over time. METHODS Data on patient and seizure characteristics were retrieved from the Swedish National Epilepsy Surgery Register. Two-year follow-up results were compared between the years 1997-2010 and 2011-2018. Preoperative investigations
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Efficacy and tolerability of lacosamide and controlled-release carbamazepine monotherapy in patients with newly diagnosed temporal lobe epilepsy: Post hoc analysis of a randomized, double-blind trial. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-13 Kiyohito Terada,Yuichi Kubota,Svetlana Dimova,Sami Elmoufti,Florin Floricel,Daya Chellun,Terence J O'Brien
PURPOSE Temporal lobe epilepsy (TLE) is often associated with drug-resistant seizures. We evaluated the efficacy and tolerability of lacosamide (LCM) versus controlled-release carbamazepine (CBZ-CR) monotherapy in adults with newly diagnosed TLE. METHODS Exploratory post hoc analysis of patients with temporal focus of localization (indicated as the only localization focus) in a double-blind, noninferiority
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Modified Atkins diet for drug-resistant epilepsy: A systematic review and meta-analysis of randomized controlled trials. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-12 Antonio Mutarelli,Alleh Nogueira,Nicole Felix,Amanda Godoi,Caroline Serafim Dagostin,Luiz Henrique Martins Castro,João Paulo Mota Telles
OBJECTIVE To evaluate the effectiveness and side-effect profile of the modified Atkins diet (MAD) compared to the usual diet (UD) in reducing seizure frequency among patients with drug-resistant epilepsy (DRE). METHODS In February 2023, we conducted an extensive search in PubMed, EMBASE, and Cochrane databases to find randomized controlled trials (RCTs) comparing MAD to UD in patients with drug-resistant
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Long-term survival and factors associated with mortality among children with infantile epileptic spasms syndrome - A retrospective cohort study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-09 Mary Iype,Thekkumkara Surendran Anish,Geetha Saradakutty,Pa Mohammed Kunju,Mini Sreedharan,Shahanaz M Ahamed
BACKGROUND AND OBJECTIVES The existing literature indicates a higher risk of mortality among children with Infantile epileptic spasms syndrome (IESS). Our aim was to find the mortality pattern and factors that affect survival among children with IESS. METHODS Children with IESS who had age of onset between one month and 24 months were included. The primary outcome was survival. We used Kaplan-Meier
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Specialist epilepsy service input following an epilepsy related unscheduled care episode. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-09 A D Marshall,D Mackay,C A Heath
BACKGROUND Emergency and unplanned epilepsy-related attendances are associated with an increased risk of subsequent death within 6 months. Although further work is required to provide a definitive explanation to account for these findings, in the interim it would seem reasonable that services are designed to ensure timely access and provide support at a time of greatest risk. We aim to determine the
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Real-world experience with cenobamate: A systematic review and meta-analysis. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-09 Konstantin L Makridis,Angela M Kaindl
PURPOSE Despite many new ASM, the rate of patients with drug-resistant epilepsy (DRE) has not changed. Cenobamate (CNB) is a novel ASM for the treatment of focal-onset seizures in adults with high seizure freedom rates in randomized controlled trials (RCT). Although CNB appears to be effective, it is not commonly prescribed to patients with DRE, resulting in a lack of "real-world data". METHODS To
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A case of infantile epileptic spasms syndrome and autism spectrum disorder with an RFX3 mutation. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-07 Michiko Torio,Kenichi Maeda,Satoshi Akamine,Saori Kawakami,Yoshie Matsubara,Fuyuki Miya,Mitsuhiro Kato,Ryutaro Kira
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Febrile infection-related epilepsy syndrome in childhood: A clinical review and practical approach. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-07 Andreas van Baalen
Febrile infection-related epilepsy syndrome (FIRES) of unknown aetiology is an extremely rare but severe epilepsy syndrome. It is characterized by a nonspecific febrile infection a few days before the onset of super-refractory status epilepticus, followed by refractory epilepsy and high morbidity in previously healthy children and young adults. To date, FIRES is incurable and irreversible. The clinical
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Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-07 Shripada Rao,Asifa Farhat,Abhijeet Rakshasbhuvankar,Sam Athikarisamy,Soumya Ghosh,Lakshmi Nagarajan
BACKGROUND Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures. METHODS A systematic review of animal and human studies was conducted to evaluate the efficacy and safety of bumetanide for neonatal seizures. PubMed, Embase, CINAHL and Cochrane databases were searched in March 2023. RESULTS 26 animal
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Clinical phenotype and genotype of NPRL2-related epilepsy: Four cases reports and literature review. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-06 Hongwei Zhang,Jie Deng,Zaifen Gao,Yaping Wang,Fen Zhao,Hongyang Zhao,Fang Fang
BACKGROUND NPRL2-related epilepsy, caused by pathogenic germline variants of the NPRL2 gene, is a newly discovered childhood epilepsy linked to enhanced mTORC1 signalling. However, the phenotype and genotype of NPRL2 variants are still poorly understood. Here, we summarize the association between the phenotype and genotype of NPRL2-related epilepsy. METHODS A retrospective analysis was conducted for
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Safety of brand name to generic substitution of lacosamide in patients with epilepsy - A prospective single-center observational study. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-04 Magdalena Bosak,Martyna Woźniak,Maciej Kasprzycki,Agnieszka Słowik
PURPOSE Lacosamide is a widely used third-generation antiseizure medication. However, there is a lack of evidence regarding the safety of substituting brand-name lacosamide with its generic version. This study aimed to determine the clinical outcomes associated with switching from the brand-name to the generic form of lacosamide (LCM) in patients with epilepsy. METHODS This prospective observational
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The impact of the COVID-19 pandemic on a cohort of adults with epilepsy. Seizure Eur. J. Epilepsy (IF 3.0) Pub Date : 2023-09-03 A D Marshall,J P Leach,D Mackay,C A Heath
OBJECTIVES The aim of this study was to assess the direct and indirect impacts of the COVID-19 pandemic on adults with epilepsy in Glasgow. METHODS We used routinely collected data for a previously identified cohort of patients with epilepsy to evaluate access to scheduled and unscheduled care with quarterly rates of inpatient admissions, outpatient attendance and accident & emergency attendance calculated