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Cover Image Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-11-23
The cover image is based on the Review Article Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions by Gongfei Li et al., https://doi.org/10.1111/ane.13717 Image Credit: Qun Wang.
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Advances in sudden unexpected death in epilepsy Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-11-10 Haiting Zhao, Lili Long, Bo Xiao
Sudden unexpected death in epilepsy (SUDEP) is the major cause of premature death in epilepsy patients, particularly those with refractory epilepsy. Sudden unexpected death in epilepsy is thought to be related to peri-ictal cardiac dysfunction, respiratory depression, and autonomic dysfunction, albeit the exact etiology is unknown. Sudden unexpected death in epilepsy prevention remains a huge challenge
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Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-10-26 Xuan Wang, Fang Yang, Beibei Chen, Wen Jiang
Most seizures in critical ill patients are non-convulsive, and some patients may develop non-convulsive status epilepticus (NCSE), a state of continuous or repetitive seizures without convulsions. With the growing use of continuous electroencephalogram (EEG) monitoring in neuro-intensive care units, non-convulsive seizure (NCS) and NCSE are increasingly diagnosed in patients with impaired consciousness
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Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-10-19 Gongfei Li, Xiao Liu, Tingting Yu, Jiechuan Ren, Qun Wang
18F-fluoro-deoxyglucose position emission tomography (18F-FDG-PET) has been proven as a sensitive and reliable tool for diagnosis of autoimmune encephalitis (AE). More attention was paid to this kind of imaging because of the shortage of MRI, EEG, and CSF findings. FDG-PET has been assessed in a few small studies and case reports showing apparent abnormalities in cases where MRI does not. Here, we
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Seizure detection based on wearable devices: A review of device, mechanism, and algorithm Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-10-18 Wen Li, Guangming Wang, Xiyuan Lei, Duozheng Sheng, Tao Yu, Gang Wang
With sudden and unpredictable nature, seizures lead to great risk of the secondary damage, status epilepticus, and sudden unexpected death in epilepsy. Thus, it is essential to use a wearable device to detect seizure and inform patients' caregivers for assistant to prevent or relieve adverse consequence. In this review, we gave an account of the current state of the field of seizure detection based
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Potassium channels and epilepsy Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-10-12 Kai Gao, Zehong Lin, Sijia Wen, Yuwu Jiang
With the development and application of next-generation sequencing technology, the aetiological diagnosis of genetic epilepsy is rapidly becoming easier and less expensive. Additionally, there is a growing body of research into precision therapy based on genetic diagnosis. The numerous genes in the potassium ion channel family constitute the largest family of ion channels: this family is divided into
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Progress in pathogenesis and therapy of Rasmussen's encephalitis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-10-03 Chongyang Tang, Wei Yang, Guoming Luan
Rasmussen's encephalitis (RE) is a rare condition of unknown etiology that causes a severe chronically neurological disorder with mostly affecting children. The main clinical feature of RE includes frequent seizures with drug-resistant, unilateral hemispheric atrophy, and progressive neurological deficits. In this review, we summarized five pathogenesis on the basis of the current research including
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Special issue on blood biomarkers in neurology Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-26 Johan Zelano, Henrik Zetterberg
CONFLICT OF INTEREST JZ has received speaker honoraria from UCB and Eisai and has been or is as an employee of Sahlgrenska University Hospital (no personal compensation) investigator in clinical trials sponsored by Bial, UCB, Sk life science, and GW Pharma. HZ has served at scientific advisory boards and/or as a consultant for Abbvie, Alector, ALZPath, Annexon, Apellis, Artery Therapeutics, AZTherapies
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The following article for the special issue were previously published and can be found in its respective issue online Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-26
Blood biomarkers for HIV infection with focus on neurologic complications—A review (146:1) https://doi.org/10.1111/ane.13629
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Blood based biomarkers for movement disorders Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-26 Huw R. Morris
Movement disorders have been carefully clinically defined, based on clinico-pathological series; however there is often diagnostic and prognostic uncertainty, especially in early stage disease. Blood-based biomarkers for Alzheimer's disease (AD), particularly p-tau181 and p-tau217, may be useful in the movement disorder clinic, especially in identifying corticobasal syndrome due to AD pathology and
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The following article for the special issue were previously published and can be found in its respective issue online Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-26
Blood biomarkers for Alzheimer's disease and related disorders (146:1) https://doi.org/10.1111/ane.13628
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Blood biomarkers in ALS: challenges, applications and novel frontiers Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-26 Ellie Sturmey, Andrea Malaspina
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among adults. With diagnosis reached relatively late into the disease process, extensive motor cell loss narrows the window for therapeutic opportunities. Clinical heterogeneity in ALS and the lack of disease-specific biomarkers have so far led to large-sized clinical trials with long follow-up needed to define clinical outcomes
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Computerized application for epilepsy in China: Does the era of artificial intelligence comes? Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-25 Yiwei Gong, Cenglin Xu, Shuang Wang, Yi Wang, Zhong Chen
Epilepsy, one of the most common neurological diseases in China, is notorious for its spontaneous, unprovoked and recurrent seizures. The etiology of epilepsy varies among individual patients, including congenital gene mutation, traumatic injury, infections, etc. This heterogeneity partly hampered the accurate diagnosis and choice of appropriate treatments. Encouragingly, great achievements have been
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Deep brain stimulation of the subthalamic nucleus for epilepsy Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-22 Hao Yan, Liankun Ren, Tao Yu
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a promising palliative option for patients with refractory epilepsy. However, crucial questions remain unanswered: Which patients are the optimal candidates? How, where, and when to stimulate the STN? And what is the mechanism of STN-DBS action on epilepsy? Thus, we reviewed the clinical evidence on the antiepileptic effects of STN-DBS
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Validity and reliability characteristics of the Silhouettes Fatigue Scale in measuring multiple sclerosis-related fatigue in Turkish-speaking adults Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-19 İsa Cüce, Yaşar Altun
The purpose of this study is to investigate the reliability and validity as well as the clinical utility of the Silhouettes Fatigue Scale (SFS), a single-item visual scale to assess fatigue, in adult patients with multiple sclerosis (MS).
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Online psychological interventions to improve symptoms in multiple sclerosis: A systematic review Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-19 Brenda Montañés-Masias, Judit Bort-Roig, Juan Carlos Pascual, Joaquim Soler, Laia Briones-Buixassa
The aim of this systematic review was to assess the effectiveness of Internet-based psychological interventions in the treatment of physical, socio-affective and cognitive symptoms and quality of life (QoL) in people with multiple sclerosis (pwMS) to provide currently available evidence.
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Prevalence and development of idiopathic normal pressure hydrocephalus: A 16-year longitudinal study in Japan Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-16 Chifumi Iseki, Yoshimi Takahashi, Michito Adachi, Ryosuke Igari, Hiroyasu Sato, Shingo Koyama, Kenichi Ishizawa, Yasuyuki Ohta, Takeo Kato
We previously investigated the preclinical state of idiopathic normal pressure hydrocephalus (iNPH): asymptomatic ventriculomegaly with features of iNPH on magnetic resonance imaging (AVIM) found in community inhabitants. The aim of the study was to determine how iNPH develops longitudinally.
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The analysis of 18F-FDG PET/MRI, electroencephalography, and semiology in patients with gray matter heterotopia: A pilot study Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-14 Ceren Alis, Deniz Alis, Lebriz Uslu Besli, Ercan Karaarslan, Kerim Sonmezoglu, Cigdem Ozkara, Seher Naz Yeni
To describe 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) along with semiology and electroencephalography (EEG) in patients with gray matter heterotopia (GMH); to evaluate the concordance between 18F-FDG PET/MRI and clinical epileptogenic zone (EZ).
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Comorbidities in patients with Unverricht–Lundborg disease (EPM1) Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-13 Jussi O. T. Sipilä, Reetta Kälviäinen
Unverricht-Lundborg disease (EPM1) typically leads to accumulating disability. Disability may also be caused by comorbidities but there are no data available on these.
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Clinical features and spectrum of NOTCH3 variants in Finnish patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-09 Saana Mönkäre, Liina Kuuluvainen, Johanna Schleutker, Liisa Myllykangas, Minna Pöyhönen
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease caused by pathogenic variants in the NOTCH3 gene. In Finland, the majority of CADASIL patients carry the pathogenic founder variant c.397C>T, (p.Arg133Cys), but the spectrum of other NOTCH3 variants has not been investigated previously. The aim of the study was to
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Neuroleptic intolerance in the context of anti-N-methyl-D-aspartate receptor encephalitis: A systematic review and synthesis of global case reports Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-09 Kevin Pacheco-Barrios, Alba Navarro-Flores, Paulo S. de Melo, Ingrid Rebello-Sanchez, Joao Parente, Elenit Diaz Asenjo, Ivan Gordillo, Sandra Zeña-Ñañez, Virgilio E. Failoc-Rojas
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis presents commonly with psychiatric symptoms. One cohort of these patients reported that antipsychotic administration led to neuroleptic intolerance (NI) in 19% of them, which was preventable by a prompt encephalitis diagnosis. To date, there is no clear description of the “neuroleptic intolerance” spectrum in general or during anti-NMDAR
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Complementary and alternative medicine for treating epilepsy in China: A systematic review Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-09 Chenyang Zhao, Lu Lu, Wenyu Liu, Dong Zhou, Xintong Wu
There are about 10 million people with epilepsy (PWE) in China. In addition to therapies approved by the National Medical Products Administration, the use of complementary and alternative medicine (CAM) is prevalent in Chines PWE. These CAM therapies mainly comprise traditional Chinese medicine herbs (TCMHs), acupuncture, and music. A retrospective literature search was performed to summarize the updates
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Effects of fast-velocity concentric resistance training in people with multiple sclerosis: A randomized controlled trial Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-09 Luis Andreu-Caravaca, Domingo J. Ramos-Campo, Linda H. Chung, Pedro Manonelles, Oriol Abellán-Aynés, Jacobo Á. Rubio-Arias
To analyze the effects of a fast-velocity concentric resistance training (FVCRT) program on maximum strength of upper and lower limb, gait speed, walking endurance, fatigue, physical self-perception, and catastrophizing pain in people with multiple sclerosis (MS).
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Effects of anti-seizure therapies on sleep in patients with epilepsy: A literature review Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-07 Lingqi Ye, Jiahui Xu, Cong Chen, Lisan Zhang, Shuang Wang
Sleep disorder is common in epilepsy. With a recent rapid development in sleep medicine, it has been increasingly recognized that anti-seizure therapies, either anti-seizure medications (ASMs) or non-pharmaceutical approaches, can take direct or indirect influence on sleep in patients with epilepsy. Here, we systematically review the effect of anti-seizure treatments on sleep. ASMs targeting at different
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Collateral circulation detected by arterial spin labeling predicts outcome in acute ischemic stroke Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-05 Sangni Liu, Dandan Fan, Feifei Zang, Nan Gu, Yun Yin, Xiao Ge, Ling Zhang, Xiang Chen, Zhengsheng Zhang, Chunming Xie
Robust collateral circulation is strongly associated with good outcomes in acute ischemic stroke (AIS).
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Restless legs syndrome due to brainstem stroke: A systematic review Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-05 Stefania Kalampokini, Sotiris Poyiadjis, George D. Vavougios, Artemios Artemiadis, Panagiotis Zis, Georgios M. Hadjigeorgiou, Panagiotis Bargiotas
Restless Legs Syndrome (RLS) is a sleep-related movement disorder, which can also result from brainstem pathology. A systematic review of articles published in the electronic databases PubMed and Web of Science was conducted to summarize the existent literature on RLS associated with a brainstem stroke. We identified eight articles including 19 subjects with RLS due to brainstem ischemic lesion. The
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Neuromodulation in drug-resistant epilepsy: A review of current knowledge Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-05 Tao Xue, Shujun Chen, Yutong Bai, Chunlei Han, Anchao Yang, Jianguo Zhang
Nearly 1% of the global population suffers from epilepsy. Drug-resistant epilepsy (DRE) affects one-third of epileptic patients who are unable to treat their condition with existing drugs. For the treatment of DRE, neuromodulation offers a lot of potential. The background, mechanism, indication, application, efficacy, and safety of each technique are briefly described in this narrative review, with
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Is there a role for off-label high-efficacy disease-modifying drugs in progressive multiple sclerosis? A network meta-analysis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-09-02 Guilherme Diogo Silva, Bruno Batitucci Castrillo, Samira Luísa Apóstolos-Pereira, Dagoberto Callegaro
Ocrelizumab and siponimod are the two on-label drugs used for progressive forms of multiple sclerosis (PMS). However, many patients with PMS do not have access to these high-efficacy disease-modifying drugs (DMDs). Off-label prescription of other high-efficacy DMDs (fingolimod, rituximab and natalizumab) may be a strategy to improve access to immunotherapy for these patients. We aim to compare on-label
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Thrombectomy in large vessel occlusion stroke—Does age matter? Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-27 Mehdi K. Rezai, Ingvild Dalen, Rajiv Advani, Lars Fjetland, Kathinka D. Kurz, Knut Olav Sandve, Martin W. Kurz
Endovascular treatment (EVT) is the gold standard treatment for emergent large vessel occlusion (LVO). The benefit of EVT for emergent LVO in elderly patients (>80 years old) is still debated as they have been under-represented in randomized controlled trials. Elderly patients with an emergent LVO are a growing population warranting further study.
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Corticosteroids in patients with vestibular neuritis: An updated meta-analysis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-27 Anna Bogdanova, Julia Dlugaiczyk, Josef Georg Heckmann, Stefan Schwab
Vestibular neuritis is a common neuro-otological entity. Therapeutically, corticosteroids are advised, although the evidence is limited. The objective of this review is to update meta-analyses of clinical trials that address the question of whether patients with vestibular neuritis treated with corticosteroids show better recovery than control patients. The electronic databases Medline, Scopus and
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Incidence of first-ever transient ischemic attack in Eastern Finland Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-27 Tiina Komulainen, Anne Koivisto, Pekka Jäkälä
The incidence of stroke has been declining in Finland, as well as in Europe. However, it is unclear whether the incidence of transient ischemic attack (TIA) is also decreasing. In fact, the TIA incidence in the Finnish population has never been reported. Therefore, here we investigated the incidence of TIA in the Eastern Finnish population in 2017.
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Identification of novel signal of clobazam-associated drug reaction with eosinophilia and systemic symptoms syndrome: A disproportionality analysis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-27 Akash Sharma, Anoop Kumar
Clobazam is a well-known benzodiazepine used as an anti-anxiety drug as well as an anti-epileptic, particularly for patients who are not responding to first-line treatments. Recent case reports have indicated the association of clobazam with drug reaction with eosinophilia systemic symptoms syndrome (DRESS Syndrome). However, DRESS syndrome is not known to be associated with clobazam. Thus, the main
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Natural history of circulating miRNAs in Duchenne disease: Association with muscle injury and metabolic parameters Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-24 Tomas Almeida-Becerril, Maricela Rodríguez-Cruz, Sthephanie Yannín Hernández-Cruz, Eugenia Dolores Ruiz-Cruz, Christian Ricardo Sánchez Mendoza, Alan Cárdenas-Conejo, Rosa Elena Escobar-Cedillo, Federico Ávila-Moreno, Guillermo Aquino-Jarquin
This study aimed to evaluate whether the expression of circulating dystromiRs and a group of oxidative stress-related (OS-R) miRNAs is associated with muscle injury and circulating metabolic parameters in Duchenne muscular dystrophy (DMD) patients.
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Progress of clinical research studies on tuberous sclerosis complex-related epilepsy in China Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-24 Tinghong Liu, Feng Chen, Feng Zhai, Shuli Liang
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome, with 75.6%–83.5% and 54.1% patients presenting with epilepsy and drug-resistant epilepsy (DRE), respectively. Clinical studies on TSC, particularly surgical interventions, have achieved rapid and substantial progress. The TSC-Task Force Committee of the China Association Against Epilepsy (CAAE-TFTSC) was founded in 2012
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Seizure control in successive pregnancies in Australian women with epilepsy Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-19 Frank J. E. Vajda, Terence J. O'Brien, Janet Graham, Alison A. Hitchcock, Piero Perucca, Cecilie M. Lander, Mervyn J. Eadie
To investigate control of epileptic seizures during pairs of successive pregnancies in antiseizure medication (ASM)-treated women with epilepsy.
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Intra- or peri-procedural rupture in the endovascular treatment of intracranial aneurysms Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-17 Fernando Delgado Acosta, Isabel Bravo Rey, Elvira Jiménez Gómez, Veredas Romero Saucedo, Alvaro Toledano, Rafael Oteros Fernández
Intra- or peri-procedural aneurysm rupture is one of the most feared adverse effects associated with embolization. Our aim was to report the characteristics of patients suffering intra- or peri-procedural ruptures during embolization of cerebral aneurysms.
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Genetic Creutzfeldt-Jakob disease in Turkish Jews—demographic and clinical features Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-16 Leslie Menendez, Ron Milo, Oren S. Cohen, Joab Chapman, Hanna Rosenmann, Zeev Nitsan, Esther Kahana, Shmuel Appel
The largest cluster of genetic Creutzfeldt- Jakob Disease (CJD) exists in Libyan Jews carrying the E200K mutation in the PRNP gene. However, there is another cluster of genetic CJD with E200K mutation in families of Turkish–Jewish origin.
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Sleep stability in isolated rapid eye movement sleep behavior disorder, Parkinson's disease, and dementia with Lewy bodies Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-16 Paulo Bugalho, Marta Magriço
Non-REM sleep symptoms remain poorly understood in alpha-synucleinopathies.
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Patient factors associated with receiving reversal therapy in oral anticoagulant-related intracerebral hemorrhage Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-16 Trine Apostolaki-Hansson, Teresa Ullberg, Bo Norrving, Jesper Petersson
We aimed to describe baseline characteristics of patients with oral anticoagulant-related intracerebral hemorrhage (OAC-ICH) in Sweden and to identify predictive variables associated with receiving hemostatic treatment in the event of OAC-ICH.
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Slow vital capacity as a useful indicator of the prognosis after percutaneous endoscopic gastrostomy in patients with amyotrophic lateral sclerosis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-16 Tatsuya Ueno, Rie Haga, Akira Arai, Masahiko Tomiyama
Forced vital capacity (FVC) is recommended as a respiratory function test in patients with amyotrophic lateral sclerosis (ALS). However, in ALS associated with orofacial palsy, FVC may be an unreliable test. Slow vital capacity (SVC) is an easier and more reliable test even in cases with bulbar symptoms. However, it remains unclear whether respiratory function tests using SVC and FVC are associated
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Interest in and exposure to headache disorders among neurology residents in Denmark: A nationwide cross-sectional survey Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-11 Malene Glavind Holmsted Kristensen, Thien Phu Do, Patricia Pozo-Rosich, Faisal Mohammad Amin
Headache disorders constitute a leading cause of disability worldwide, but there is a consistent absence of awareness and educational activities for healthcare providers across regions. Thus, we found it timely to identify potential structural challenges and factors that may affect acquisition of knowledge of headache disorders and their management during their 4-year residency.
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Alteplase for ischemic stroke: A giant with feet of clay? Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-03 Francesco Brigo
CONFLICT OF INTEREST None.
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Miller Fisher syndrome following COVID-19 vaccines: A scoping review Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-08 Jee-Eun Kim, Byeol-A Yoon, Yoo Hwan Kim, Jong Kuk Kim, Jong Seok Bae
Miller Fisher syndrome (MFS), a variant of Guillain–Barré Syndrome (GBS), could be underestimated in evaluations of its adverse events (AEs) following COVID-19 vaccination. We aimed to identify and characterize MFS following COVID-19 vaccination.
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Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-05 Patrick R. Avelino, Lucas R. Nascimento, Kênia K. P. Menezes, Gisele A. Sousa, Maria Tereza Alvarenga, Luci F. Teixeira-Salmela, Jordana de Paula Magalhães, Aline Alvim Scianni
To explore the relationship between walking measurements (i.e., walking speed, walking performance and walking confidence), and participation in ambulatory people with chronic stroke.
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Clinical features of Guillain–Barré syndrome with anti-neurofascin 155 antibody Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-04 Ning Zhao, Sheng-Hui Chang, Qiu-Xia Zhang, Lin-Jie Zhang, Shu-Min Jiang, Hui Zhai, Li Yang
Anti-neurofascin 155 (NF155) antibody has been discovered in chronic demyelinating conditions. However, the positive rate and clinical description were insufficient in acute demyelinating conditions, such as Guillain–Barré syndrome (GBS). This study aimed to explore the positive rate of anti-NF155 antibody in GBS patients and determine whether there were unique clinical characteristics in these patients
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Cotinine levels influence the risk of rupture of brain aneurysms Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-08-03 Paolo Missori, Diana Aguiar de Sousa, Angela Ambrosone, Antonio Currà, Sergio Paolini, Giorgio Incarbone, Elena Amabile, Francesco Biraschi, Francesco Diana, Simone Peschillo
Cotinine, the primary metabolite of nicotine, is currently regarded as the best biomarker of tobacco smoke exposure. We aim to assess whether cotinine levels are associated with (1) intracranial aneurysm and (2) intracranial aneurysm rupture.
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Adverse effects of levodopa/carbidopa intrajejunal gel treatment: A single-center long-term follow-up study Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-28 Tomaž Rus, Maša Premzl, Nina Z. Križnar, Milica G. Kramberger, Robert Rajnar, Lidija Ocepek, Zvezdan Pirtošek, Maja Trošt
Levodopa/carbidopa intrajejunal gel (LCIG) is an effective therapeutic strategy to overcome levodopa-induced motor complications in advanced Parkinson's disease (PD). However, it requires invasive percutaneous endoscopic gastrojejunostomy (PEG-J) and may be associated with serious adverse effects (AE). In this study, we aimed to evaluate long-term AEs related to LCIG treatment in a large homogenous
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Effects of robotic rehabilitation on recovery of hand functions in acute stroke: A preliminary randomized controlled study Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-20 Dilber Karagozoglu Coskunsu, Sumeyye Akcay, Ozden Erkan Ogul, D. Kubra Akyol, Necla Ozturk, Füsun Zileli, Birgul Baştan Tuzun, Yakup Krespi
The aim of this study was to investigate the effects of EMG-driven robotic rehabilitation on hand motor functions and daily living activities of patients with acute ischemic stroke.
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Long-term outcomes after aneurysmal subarachnoid hemorrhage: A prospective observational cohort study Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-18 Sandra Bjerkne Wenneberg, Linda Block, Ann Sörbo, Silvana Naredi, Jonatan Oras, Pia Löwhagen Hendén, Johan Ljungqvist, Jaquette Liljencrantz, Helena Odenstedt Hergès
The survival rates for patients affected by aneurysmal subarachnoid hemorrhage (aSAH) have increased in recent years; however, many patients continue to develop cognitive dysfunctions that affect their quality of life. The commonly used outcome measures often fail to identify these cognitive dysfunctions. This study aimed to evaluate the long-term outcomes at 1 and 3 years after aSAH to assess changes
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Temporal trends of epilepsy in multiple sclerosis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-18 Zamzam Mahamud, Joachim Burman, Johan Zelano
Epilepsy is associated with advanced multiple sclerosis (MS). We aimed to investigate whether the incidence of epilepsy in MS has been affected by the introduction of disease-modifying treatments (DMT) for MS.
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Fluid biomarkers in stroke: From animal models to clinical care Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-15 Alexandre Dias, Lénia Silva, João Moura, Denis Gabriel, Luis F. Maia
Stroke is a leading cause of death and disability worldwide. Stroke prevention, early diagnosis, and efficient acute treatment are priorities to successfully impact stroke death and disability. Fluid biomarkers may improve stroke differential diagnostic, patient stratification for acute treatment, and post-stroke individualized rehabilitation. In the present work, we characterized the use of stroke
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Publication of neurology clinical trials registered with clinical trial registry of India: A cross-sectional study Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-15 Biswamohan Mishra, Ayush Agarwal, Nilima Nilima, M. V. Padma Srivastava, Venugopalan Y. Vishnu
Unbiased and full disclosure of trial results is vital to evidence-based medicine. Non-publication and selective publication leads to publication bias and unrealistic risk–benefit ratio. In the present study, we aim to determine the publication rate of clinical trials related to neurology registered with the Clinical Trial Registry of India (CTRI), compare the characteristics of published and unpublished
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Early post-traumatic seizures in hospitalized patients with traumatic brain injury Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-14 Hild Flatmark Sødal, Gøril Storvig, Cathrine Tverdal, Hilde Stendal Robinson, Eirik Helseth, Erik Taubøll
Early post-traumatic seizures (EPTS) are a well-known complication of traumatic brain injury (TBI). EPTS increase the risk of secondary brain injury and may cause significant challenges during the period of critical care. Routine use of prophylactic anti-seizure medication is controversial due to conflicting reports on efficacy and risk of adverse effects. The purpose of this study was to expand the
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Fatigue 7 years post-stroke: Predictors and correlated features Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-05 Annie Pedersen, Emelie Almkvist, Lukas Holmegaard, Cecilia Lagging, Petra Redfors, Christian Blomstrand, Katarina Jood, Hans Samuelsson, Christina Jern
Post-stroke fatigue (PSF) is common with great impact on quality of life. We explored predictive and cross-sectionally correlated features in the long term after ischemic stroke.
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Atypical painful stroke presentations: A review Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-05 Michael Bayat, Allan Bayat, Rolf A. Blauenfeldt
Stroke is a leading cause of death and disability. Some patients may present with atypical symptoms. One of the very rare presentations of stroke is initial neurogenic pain. Rare painful presentations include, amongst others, acute trigeminal neuralgia, atypical facial pain, hemi-sensory pain, and episodic pain. Based on the available literature, the pain at presentation may be episodic, transient
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Hands–feet wireless devices: Test–retest reliability and discriminant validity of motor measures in Parkinson's disease telemonitoring Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-05 Carlo Maremmani, Erika Rovini, Stefano Salvadori, Alessandro Pecori, Jacopo Pasquini, Andrea Ciammola, Simone Rossi, Giulia Berchina, Roberto Monastero, Filippo Cavallo
Telemonitoring, a branch of telemedicine, involves the use of technological tools to remotely detect clinical data and evaluate patients. Telemonitoring of patients with Parkinson's disease (PD) should be performed using reliable and discriminant motor measures. Furthermore, the method of data collection and transmission, and the type of subjects suitable for telemonitoring must be well defined.
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Self-employment, sickness absence, and disability pension in multiple sclerosis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-04 Alejandra Machado, Chantelle Murley, Jan Hillert, Kristina Alexanderson, Emilie Friberg
Early withdrawal from work is common among people with multiple sclerosis (PwMS). However, little is known about how this is influenced by the type of employment. The aims were to explore the distributions of self-employed and other types of employment (employed or no earnings from work) before and after MS diagnosis and its associations with sickness absence (SA) and disability pension (DP) among
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Stroke thrombolysis - Is more better? Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-07-01 Peter Appelros
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Greater occipital nerve block for chronic migraine patients: A meta-analysis Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-06-21 Victor Velásquez-Rimachi, Jorge Chachaima-Mar, Elena Cristina Cárdenas-Baltazar, Alejandra Loayza-Vidalon, Cristian Morán-Mariños, Kevin Pacheco-Barrios, Margarita Posso, Carlos Alva-Díaz
Greater occipital nerve block (GONB) is a minimally invasive procedure frequently used in patients with chronic migraine (CM); however, the quality of the evidence supporting its use is still unknown. Therefore, we aimed to conduct a systematic review, meta-analysis and quality assessment of GONB local anaesthetics combined or not with corticosteroids to prevent CM.
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Prevalence and affective correlates of subjective cognitive decline in patients with de novo Parkinson's disease Acta Neurol. Scand. (IF 3.5) Pub Date : 2022-06-20 Ning Yang, Yuanyuan Ju, Jingru Ren, Haidong Wang, Peishan Li, Houxu Ning, Jiaping Tao, Weiguo Liu
The novel concept of subjective cognitive decline (SCD) in Parkinson's disease (PD) refers to subjective cognitive impairment without concurrent objective cognitive deficits. This study aimed to determine the prevalence and affective correlates of SCD in de novo PD patients.