-
Clinical outcomes among initial survivors of cryptogenic new-onset refractory status epilepsy (NORSE) Epilepsia (IF 5.6) Pub Date : 2024-03-18 Daniel J. Costello, Elizabeth Matthews, Sidra Aurangzeb, Elisabeth Doran, Jessica Stack, Robb Wesselingh, Patricia Dugan, Hyunmi Choi, Chantal Depondt, Orrin Devinsky, Colin Doherty, Patrick Kwan, Mastura Monif, Terence J. O'Brien, Arjune Sen, Nicolas Gaspard
New-onset refractory status epilepticus (NORSE) is a rare but severe clinical syndrome. Despite rigorous evaluation, the underlying cause is unknown in 30%–50% of patients and treatment strategies are largely empirical. The aim of this study was to describe clinical outcomes in a cohort of well-phenotyped, thoroughly investigated patients who survived the initial phase of cryptogenic NORSE managed
-
Epilepsia – March 2024 Announcements Epilepsia (IF 5.6) Pub Date : 2024-03-18
ILAE CONGRESSES 4th ILAE School on Neuropsychology in Epilepsy 3–8 March 2024 Lyon, France 6th ILAE School on EEG in the First Year of Life: From newborn to toddler 25–28 March 2024 Cambridge, UK & Online ILAE School on Neuroimaging 2024 (AMIE & SuSIE 2024) 15–18 May 2024 Potsdam, Berlin & Online XIII Congreso Latinoamericano de Epilepsia 15–18 June 2024 Santo Domingo, República Dominicana 6th ILAE
-
Clinical and molecular characterization of patients with YWHAG-related epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-16 Valentina Cetica, Tiziana Pisano, Gaetan Lesca, Dana Marafi, Laura Licchetta, Florence Riccardi, Davide Mei, Hon-yin B. Chung, Allan Bayat, Meena Balasubramanian, Daniel H. Lowenstein, Milda Endzinienė, Maha Alotaibi, Nathalie Villeneuve, Julia Jacobs, Bertrand Isidor, Roberta Solazzi, Nicolette S. den Hollander, Dragan Marjanovic, Christelle Rougeot-Jung, Julien Jung, Marion Lesieur-Sebellin, Andrea
YWHAG variant alleles have been associated with a rare disease trait whose clinical synopsis includes an early onset epileptic encephalopathy with predominantly myoclonic seizures, developmental delay/intellectual disability, and facial dysmorphisms. Through description of a large cohort, which doubles the number of reported patients, we further delineate the spectrum of YWHAG-related epilepsy.
-
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography Epilepsia (IF 5.6) Pub Date : 2024-03-16 Stanislas Lagarde, Julien Modolo, Maxime Yochum, Andres Carvallo, Alice Ballabeni, Didier Scavarda, Romain Carron, Nathalie Villeneuve, Fabrice Bartolomei, Fabrice Wendling
ObjectiveWe have developed a novel method for estimating brain tissue electrical conductivity using low‐intensity pulse stereoelectroencephalography (SEEG) stimulation coupled with biophysical modeling. We evaluated the hypothesis that brain conductivity is correlated with the degree of epileptogenicity in patients with drug‐resistant focal epilepsy.MethodsWe used bipolar low‐intensity biphasic pulse
-
Somatic variants as a cause of drug‐resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis Epilepsia (IF 5.6) Pub Date : 2024-03-16 Robert J. Carton, Michael G. Doyle, Hugh Kearney, Charles A. Steward, Nicholas J. Lench, Anthony Rogers, Erin L. Heinzen, Seamus McDonald, Joanna Fay, Austin Lacey, Alan Beausang, Jane Cryan, Francesca Brett, Hany El‐Naggar, Peter Widdess‐Walsh, Daniel Costello, Ronan Kilbride, Colin P. Doherty, Kieron J. Sweeney, Donncha F. O'Brien, David C. Henshall, Norman Delanty, Gianpiero L. Cavalleri, Katherine
ObjectiveThe contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug‐resistant
-
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures Epilepsia (IF 5.6) Pub Date : 2024-03-16 Dannielle K. Zierath, Stephanie Davidson, Jonathan Manoukian, Kevin M. Knox, H. Steve White, Stacey Meeker, Aaron Ericsson, Melissa Barker‐Haliski
ObjectiveBrain infection with Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6J mice can induce acquired epileptogenesis. Diet alters acute seizure incidence in TMEV‐infected mice; yet it is unclear whether intestinal dysbiosis may also impact acute or chronic behavioral comorbidities. This study thus assessed the impact of diet formulation and sterilization on acute seizure presentation
-
Why did my seizures start now? Influences of lesion connectivity and genetic etiology on age at seizure onset in focal epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-16 Emma Macdonald‐Laurs, Aaron E. L. Warren, Richard J. Leventer, A. Simon Harvey
ObjectivePatients with focal, lesional epilepsy present with seizures at variable ages. Larger lesion size and overlap with sensorimotor or default mode network (DMN) have been associated with younger age at seizure onset in cohorts with mixed types of focal cortical dysplasia (FCD). Here, we studied determinants of age at seizure onset in patients with bottom‐of‐sulcus dysplasia (BOSD), a discrete
-
MyD88‐mediated signaling is critical for the generation of seizure responses and cognitive impairment in a model of anti‐N‐methyl‐D‐aspartate receptor encephalitis Epilepsia (IF 5.6) Pub Date : 2024-03-12 Olga Taraschenko, Howard S. Fox, Ember Eldridge, Priscilla Heliso, Fetweh Al‐Saleem, Scott Dessain, George Casale, Gregory Willcockson, Kayley Anderson, Wenyi Wang, Raymond Dingledine
ObjectiveWe previously demonstrated that interleukin‐1 receptor‐mediated immune activation contributes to seizure severity and memory loss in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. In the present study, we assessed the role of the myeloid differentiation primary response gene 88 (MyD88), an adaptor protein in Toll‐like receptor signaling, in the key phenotypic characteristics of anti‐NMDAR
-
Association of midazolam route of administration and need for recurrent dosing among children with seizures cared for by emergency medical services Epilepsia (IF 5.6) Pub Date : 2024-03-12 Sriram Ramgopal, Sylvia Owusu‐Ansah, Remle P. Crowe, Masashi Okubo, Christian Martin‐Gill
ObjectiveNational guidelines in the United States recommend the intramuscular and intranasal routes for midazolam for the management of seizures in the prehospital setting. We evaluated the association of route of midazolam administration with the use of additional benzodiazepine doses for children with seizures cared for by emergency medical services (EMS).MethodsWe conducted a retrospective cohort
-
Specific consistency score for rational selection of epilepsy resection surgery candidates Epilepsia (IF 5.6) Pub Date : 2024-03-12 Maya Tojima, Akihiro Shimotake, Shuichiro Neshige, Tadashi Okada, Katsuya Kobayashi, Kiyohide Usami, Masao Matsuhashi, Masayuki Honda, Hirofumi Takeyama, Takefumi Hitomi, Takeshi Yoshida, Atsushi Yokoyama, Yasutaka Fushimi, Tsukasa Ueno, Yukihiro Yamao, Takayuki Kikuchi, Takao Namiki, Yoshiki Arakawa, Ryosuke Takahashi, Akio Ikeda
ObjectiveDegree of indication for epilepsy surgery is determined by taking multiple factors into account. This study aimed to investigate the usefulness of the Specific Consistency Score (SCS), a proposed score for focal epilepsy to rate the indication for epilepsy focal resection.MethodsThis retrospective cohort study included patients considered for resective epilepsy surgery in Kyoto University
-
Comprehensive phenotypes of patients with SYNGAP1‐related disorder reveals high rates of epilepsy and autism Epilepsia (IF 5.6) Pub Date : 2024-03-12 Kimberly Wiltrout, Elise Brimble, Annapurna Poduri
ObjectiveTo delineate the comprehensive phenotypic spectrum of SYNGAP1‐related disorder in a large patient cohort aggregated through a digital registry.MethodsWe obtained de‐identified patient data from an online registry. Data were extracted from uploaded medical records. We reclassified all SYNGAP1 variants using American College of Medical Genetics criteria and included patients with pathogenic/likely
-
Effect of levodopa on pathological gait in Dravet syndrome: A randomized crossover trial using three‐dimensional gait analysis Epilepsia (IF 5.6) Pub Date : 2024-03-12 Takeshi Suzuki, Jun Natsume, Yuji Ito, Tadashi Ito, Koji Noritake, Fumie Kinoshita, Tatsuya Fukasawa, Takeshi Tsuji, Kazuya Itomi, Hirokazu Kurahashi, Kazuo Kubota, Tohru Okanishi, Shinji Saitoh, Hideshi Sugiura, Hirohisa Watanabe, Yoshiyuki Takahashi, Hiroyuki Kidokoro
ObjectiveIndividuals with Dravet syndrome (DS) exhibit progressive gait disturbance. No quantitative studies have been conducted to evaluate the effectiveness of medication for gait disturbance. Therefore, the aim of this study was to evaluate the effectiveness of levodopa for pathological gait in people with DS using three‐dimensional gait analysis (3DGA).MethodsNine individuals with DS, ages 6–20
-
A comprehensive systematic literature review of the burden of illness of Lennox–Gastaut syndrome on patients, caregivers, and society Epilepsia (IF 5.6) Pub Date : 2024-03-08 J. Helen Cross, Arturo Benítez, Jeannine Roth, J. Scott Andrews, Drishti Shah, Emma Butcher, Aimee Jones, Joseph Sullivan
Fully elucidating the burden that Lennox–Gastaut syndrome (LGS) places on individuals with the disease and their caregivers is critical to improving outcomes and quality of life (QoL). This systematic literature review evaluated the global burden of illness of LGS, including clinical symptom burden, care requirements, QoL, comorbidities, caregiver burden, economic burden, and treatment burden (PROSPERO
-
Delays in the diagnosis and surgical treatment of drug‐resistant epilepsy: A cohort study Epilepsia (IF 5.6) Pub Date : 2024-03-08 Justin M. Campbell, Samantha Yost, Diwas Gautam, Alysha Herich, David Botros, Mason Slaughter, Michael Chodakiewitz, Amir Arain, Angela Peters, Sindhu Richards, Blake Newman, Brian Johnson, Shervin Rahimpour, Ben Shofty
ObjectiveDelay in referral for epilepsy surgery of patients with drug‐resistant epilepsy (DRE) is associated with decreased quality of life, worse surgical outcomes, and increased risk of sudden unexplained death in epilepsy (SUDEP). Understanding the potential causes of delays in referral and treatment is crucial for optimizing the referral and treatment process. We evaluated the treatment intervals
-
Transient postictal dysphagia in older adults with focal structural epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-08 Sriramya Lapa, Anna Schwingshackl, Ulrike Frank, Felix Rosenow, Catrin Mann, Adam Strzelczyk
ObjectiveSeizures can cause transient neurological symptoms, such as hemiparesis and aphasia. However, temporary swallowing changes leading to postictal dysphagia have not been previously described. Therefore, this study evaluated the presence of swallowing disorders following seizure. In addition, dysphagia severity and duration of any recovery from dysphagic symptoms were investigated.MethodsThe
-
A global update on cenobamate based on real‐world experience in over 100 000 patients Epilepsia (IF 5.6) Pub Date : 2024-03-06 Louis Ferrari, William E. Rosenfeld, Marc Kamin
Since cenobamate's launch in 2020, more than 100 000 patients have been treated with the medication worldwide. Here, we provide an important update to the epilepsy community on real-world experience with cenobamate almost 4 years post-launch. When a new anti-seizure medication (ASM) is approved, postmarketing data provide health care professionals with a valuable source of information for large numbers
-
Health care utilization and mortality for people with epilepsy during COVID‐19: A population study Epilepsia (IF 5.6) Pub Date : 2024-03-05 Huw Strafford, Joe Hollinghurst, Arron S. Lacey, Ashley Akbari, Alan Watkins, Jan Paterson, Daniel Jennings, Ronan A. Lyons, H. Robert Powell, Michael P. Kerr, Richard F. Chin, William O. Pickrell
ObjectiveThis study was undertaken to characterize changes in health care utilization and mortality for people with epilepsy (PWE) during the COVID‐19 pandemic.MethodsWe performed a retrospective study using linked, individual‐level, population‐scale anonymized health data from the Secure Anonymised Information Linkage databank. We identified PWE living in Wales during the study “pandemic period” (January
-
Epilepsy and the risk of COVID‐19‐related hospitalization and death: A population study Epilepsia (IF 5.6) Pub Date : 2024-03-05 Huw Strafford, Joe Hollinghurst, Arron S. Lacey, Ashley Akbari, Alan Watkins, Jan Paterson, Daniel Jennings, Ronan A. Lyons, H. Robert Powell, Michael P. Kerr, Richard F. Chin, William O. Pickrell
ObjectivePeople with epilepsy (PWE) may be at an increased risk of severe COVID‐19. It is important to characterize this risk to inform PWE and for future health and care planning. We assessed whether PWE were at higher risk of being hospitalized with, or dying from, COVID‐19.MethodsWe performed a retrospective cohort study using linked, population‐scale, anonymized electronic health records from the
-
Ring 20 syndrome: A call to action Epilepsia (IF 5.6) Pub Date : 2024-03-05 William D. James, Rudolf Roth, Mark Fitzgerald
-
Evidence for interictal blood–brain barrier dysfunction in people with epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-04 Johannes T. Reiter, Freya Schulte, Tobias Bauer, Bastian David, Christoph Endler, Alexander Isaak, Fabiane Schuch, Felix Bitzer, Juri‐Alexander Witt, Elke Hattingen, Ralf Deichmann, Ulrike Attenberger, Albert J. Becker, Christoph Helmstaedter, Alexander Radbruch, Rainer Surges, Alon Friedman, Theodor Rüber
ObjectiveInterictal blood–brain barrier dysfunction in chronic epilepsy has been demonstrated in animal models and pathological specimens. Ictal blood–brain barrier dysfunction has been shown in humans in vivo using an experimental quantitative magnetic resonance imaging (MRI) protocol. Here, we hypothesized that interictal blood–brain barrier dysfunction is also present in people with drug‐resistant
-
Second‐line immunotherapy in new onset refractory status epilepticus Epilepsia (IF 5.6) Pub Date : 2024-03-02 Aurélie Hanin, Eyal Muscal, Lawrence J. Hirsch
Several pieces of evidence suggest immune dysregulation could trigger the onset and modulate sequelae of new onset refractory status epilepticus (NORSE), including its subtype with prior fever known as febrile infection‐related epilepsy syndrome (FIRES). Consensus‐driven recommendations have been established to guide the initiation of first‐ and second‐line immunotherapies in these patients. Here,
-
Computer vision for automated seizure detection and classification: A systematic review Epilepsia (IF 5.6) Pub Date : 2024-03-01 Brandon M. Brown, Aidan M. H. Boyne, Adel M. Hassan, Anthony K. Allam, R. James Cotton, Zulfi Haneef
Computer vision (CV) shows increasing promise as an efficient, low‐cost tool for video seizure detection and classification. Here, we provide an overview of the fundamental concepts needed to understand CV and summarize the structure and performance of various model architectures used in video seizure analysis. We conduct a systematic literature review of the PubMed, Embase, and Web of Science databases
-
New onset refractory status epilepticus: Summary of the NORSE Institute roundtable during the 2023 American Epilepsy Society meeting, Orlando, Florida Epilepsia (IF 5.6) Pub Date : 2024-02-29 Aurélie Hanin, Krista Eschbach, Teneille E. Gofton, Margaret Gopaul, Charles L. Howe, Yi‐Chen Lai, Sookyong Koh, Haying Shen, Lawrence J. Hirsch
-
Correction to “Long‐term efficacy and safety of cannabidiol in patients with treatment‐resistant epilepsies: Four‐year results from the expanded access program” Epilepsia (IF 5.6) Pub Date : 2024-02-29
Szaflarski JP, Devinsky O, Lopez M, Park YD, Zentil PP, Patel AD, et al. Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies: Four-year results from the expanded access program. Epilepsia. 2023;64:619–629. https://doi.org/10.1111/epi.17496. In the Results section, 3.1 Patients, it reads “The median age of patients was 13.5 years (range = 0–74.5) in the safety
-
Grading system for assessing the confidence in the epileptogenic zone reported in published studies: A Delphi consensus study Epilepsia (IF 5.6) Pub Date : 2024-02-29 Philippe Ryvlin, Carmen Barba, Fabrice Bartolomei, Christoph Baumgartner, Milan Brazdil, Daniel Fabo, Firas Fahoum, Birgit Frauscher, Akio Ikeda, Samden Lhatoo, Jayanti Mani, Aileen McGonigal, Eeva‐Liisa Metsahonkala, Ioana Mindruta, Dang Khoa Nguyen, Sylvain Rheims, Rodrigo Rocamora, Bertil Rydenhag, Stephan Schuele, Andreas Schulze‐Bonhage, Rainer Surges, Serge Vulliemoz, Sandor Beniczky
ObjectiveThis study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in the localization of the epileptogenic zone (EZ) as reported in published studies, to harmonize and facilitate systematic reviews in the field of epilepsy surgery.MethodsWe conducted a Delphi study involving 22 experts from 18 countries, who were asked to rate
-
Lacosamide and pregnancy: Data from spontaneous and solicited reports Epilepsia (IF 5.6) Pub Date : 2024-02-27 Piero Perucca, Dimitrios Bourikas, P. Emanuela Voinescu, Lata Vadlamudi, Daya Chellun, Thomas Kumke, Konrad J. Werhahn, Bettina Schmitz
-
Sleep physiology in patients with epilepsy: Influence of seizures on rapid eye movement (REM) latency and REM duration Epilepsia (IF 5.6) Pub Date : 2024-02-27 Alexandrea Kilgore‐Gomez, Gina Norato, William H. Theodore, Sara K. Inati, Shareena A. Rahman
ObjectiveA well‐established bidirectional relationship exists between sleep and epilepsy. Patients with epilepsy tend to have less efficient sleep and shorter rapid eye movement (REM) sleep. Seizures are far more likely to arise from sleep transitions and non‐REM sleep compared to REM sleep. Delay in REM onset or reduction in REM duration may have reciprocal interactions with seizure occurrence. Greater
-
Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA‐Epilepsy study Epilepsia (IF 5.6) Pub Date : 2024-02-27 Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J. O'Brien, Marina K. M. Alvim, Donatello Arienzo, Ítalo K. Aventurato, Alice Ballerini, Gabriel F. Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S. Duncan, Jerome P. Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini
ObjectiveThe intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross‐sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA‐Epilepsy
-
Association of antiseizure medications and adverse cardiovascular events: A global health federated network analysis Epilepsia (IF 5.6) Pub Date : 2024-02-27 Josephine Mayer, Gashirai K. Mbizvo, Tommaso Bucci, Anthony Marson, Gregory Y. H. Lip
ObjectiveA diagnosis of epilepsy has been associated with adverse cardiovascular events (CEs), but the extent to which antiseizure medications (ASMs) may contribute to this is not well understood. The aim of this study was to compare the risk of adverse CEs associated with ASM in patients with epilepsy (PWE).MethodsA retrospective case–control cohort study was conducted using TriNetX, a global health
-
Genotype–phenotype associations in 1018 individuals with SCN1A‐related epilepsies Epilepsia (IF 5.6) Pub Date : 2024-02-27 Declan Gallagher, Eduardo Pérez‐Palma, Tobias Bruenger, Ismael Ghanty, Eva Brilstra, Berten Ceulemans, Nicole Chemaly, Iris de Lange, Christel Depienne, Renzo Guerrini, Davide Mei, Rikke S. Møller, Rima Nabbout, Brigid M. Regan, Amy L. Schneider, Ingrid E. Scheffer, An‐Sofie Schoonjans, Joseph D. Symonds, Sarah Weckhuysen, Sameer M. Zuberi, Dennis Lal, Andreas Brunklaus
ObjectiveSCN1A variants are associated with epilepsy syndromes ranging from mild genetic epilepsy with febrile seizures plus (GEFS+) to severe Dravet syndrome (DS). Many variants are de novo, making early phenotype prediction difficult, and genotype–phenotype associations remain poorly understood.MethodsWe assessed data from a retrospective cohort of 1018 individuals with SCN1A‐related epilepsies.
-
Efficacy and safety of corticosteroids and ACTH in epileptic syndromes beyond Infantile Epileptic Spasms Syndrome (IESS): A systematic review and meta‐analysis Epilepsia (IF 5.6) Pub Date : 2024-02-27 Rudolf Korinthenberg, Thomas Bast, Edda Haberlandt, Ulrich Stephani, Adam Strzelczyk, Gerta Rücker
We conducted a systematic review investigating the efficacy and tolerability of adrenocorticotropic hormone (ACTH) and corticosteroids in children with epilepsies other than infantile epileptic spasm syndrome (IESS) that are resistant to anti‐seizure medication (ASM). We included retrospective and prospective studies reporting on more than five patients and with clear case definitions and descriptions
-
Hospital variation of outcomes in status epilepticus Epilepsia (IF 5.6) Pub Date : 2024-02-26 Samuel W. Terman, Elan L. Guterman, Chun C. Lin, Michael P. Thompson, James F. Burke
ObjectiveUnderstanding factors driving variation in status epilepticus outcomes would be critical to improve care. We evaluated the degree to which patient and hospital characteristics explained hospital‐to‐hospital variability in intubation and postacute outcomes.MethodsThis was a retrospective cohort study of Medicare beneficiaries admitted with status epilepticus between 2009 and 2019. Outcomes
-
Therapeutic drug monitoring in pregnancy: Levetiracetam Epilepsia (IF 5.6) Pub Date : 2024-02-24 Noam Fallik, Ilia Trakhtenbroit, Firas Fahoum, Lilach Goldstein
ObjectiveLevetiracetam (LEV) is an antiseizure medication that is mainly excreted by the kidneys. Due to its low teratogenic risk, LEV is frequently prescribed for women with epilepsy (WWE). Physiological changes during gestation affect the pharmacokinetic characteristics of LEV. The goal of our study was to characterize the changes in LEV clearance during pregnancy and the postpartum period, to better
-
Pharmacokinetics of Staccato® alprazolam in healthy adult participants in two phase 1 studies: An open‐label smoker study and a randomized, placebo‐controlled ethnobridging study Epilepsia (IF 5.6) Pub Date : 2024-02-24 Yoshinobu Hayakawa, Chiara Rospo, Ana Paula Bartmann, Aliceson King, Robert Roebling, Hugues Chanteux
-
Defining benchmark outcomes for mesial temporal lobe epilepsy surgery: A global multicenter analysis of 1119 cases Epilepsia (IF 5.6) Pub Date : 2024-02-24 Richard Drexler, Franz L. Ricklefs, Sharona Ben‐Haim, Anna Rada, Friedrich Wörmann, Thomas Cloppenborg, Christian G. Bien, Matthias Simon, Thilo Kalbhenn, Albert Colon, Kim Rijkers, Olaf Schijns, Valeri Borger, Rainer Surges, Hartmut Vatter, Michele Rizzi, Marco de Curtis, Giuseppe Didato, Nicoló Castelli, Alexandre Carpentier, Bertrand Mathon, Clarissa Lin Yasuda, Fernando Cendes, Poodipedi Sarat
ObjectiveBenchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug‐resistant mesial temporal lobe epilepsy (MTLE).MethodsThis retrospective multicenter study included patients who underwent MTLE surgery at 19 expert centers on five continents. Benchmarks
-
Analysis of seizure‐cluster circadian periodicity from a long‐term, open‐label safety study of diazepam nasal spray Epilepsia (IF 5.6) Pub Date : 2024-02-23 Nathan B. Fountain, Mark Quigg, Charles F. Murchison, Enrique Carrazana, Adrian L. Rabinowicz
ObjectiveSeizure clusters require prompt medical treatment to minimize possible progression to status epilepticus, increased health care use, and disruptions to daily life. Isolated seizures may exhibit cyclical patterns, including circadian and longer rhythms. However, little is known about the cyclical patterns in seizure clusters. This post hoc analysis of data from a long‐term, phase 3, open‐label
-
Preoperative structural–functional coupling at the default mode network predicts surgical outcomes of temporal lobe epilepsy Epilepsia (IF 5.6) Pub Date : 2024-02-23 Chunyao Zhou, Fangfang Xie, Dongcui Wang, Xiaoting Huang, Danni Guo, Yangsa Du, Ling Xiao, Dingyang Liu, Bo Xiao, Zhiquan Yang, Li Feng
ObjectiveStructural–functional coupling (SFC) has shown great promise in predicting postsurgical seizure recurrence in patients with temporal lobe epilepsy (TLE). In this study, we aimed to clarify the global alterations in SFC in TLE patients and predict their surgical outcomes using SFC features.MethodsThis study analyzed presurgical diffusion and functional magnetic resonance imaging data from 71
-
Effects of midazolam on high-frequency oscillations in amygdala and hippocampus of epilepsy patients Epilepsia (IF 5.6) Pub Date : 2024-02-17 Jonas M. Hebel, Michael Lanz, Thomas Malina, Stefan R. G. Stodieck, Michel Le Van Quyen
High-frequency oscillations (HFOs) are associated with normal brain function, but are also increasingly recognized as potential biomarkers of epileptogenic tissue. Considering the important role of interneuron activity in physiological HFO generation, we studied their modulation by midazolam (MDZ), an agonist of γ-aminobutyric acid type A (GABAA)–benzodiazepine receptors. Here, we analyzed 80 intracranial
-
Minimum clinical utility standards for wearable seizure detectors: A simulation study Epilepsia (IF 5.6) Pub Date : 2024-02-17 Daniel M. Goldenholz, Philippa J. Karoly, Pedro F. Viana, Ewan Nurse, Tobias Loddenkemper, Andreas Schulze-Bonhage, Solveig Vieluf, Elisa Bruno, Mona Nasseri, Mark P. Richardson, Benjamin H. Brinkmann, M. Brandon Westover
Epilepsy management employs self-reported seizure diaries, despite evidence of seizure underreporting. Wearable and implantable seizure detection devices are now becoming more widely available. There are no clear guidelines about what levels of accuracy are sufficient. This study aimed to simulate clinical use cases and identify the necessary level of accuracy for each.
-
Immediate and long-term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross-sectional international survey Epilepsia (IF 5.6) Pub Date : 2024-02-15 Vineet Punia, Sanaya Daruvala, Monica B. Dhakar, Sahar F. Zafar, Clio Rubinos, Neishay Ayub, Lawrence J. Hirsch, Adithya Sivaraju
Acute symptomatic seizures (ASyS) and epileptiform abnormalities (EAs) on electroencephalography (EEG) are commonly encountered following acute brain injury. Their immediate and long-term management remains poorly investigated. We conducted an international survey to understand their current management.
-
Benzodiazepines for pediatric epilepsies and their risks in a cohort within the French health care data Epilepsia (IF 5.6) Pub Date : 2024-02-14 Stéphane Auvin, Sylvie Guillo, Yann de Rycke, Diep Tran, Florence Tubach
The management of antiseizure treatment in patients with epilepsy relies on the benefit–risk ratio. Data on antiseizure medication (ASM) use in children are limited. We described antiseizure medication use in children with epilepsy (CwE) in France, with a focus on the chronic use of benzodiazepines and related implications.
-
Current state of the epilepsy drug and device pipeline Epilepsia (IF 5.6) Pub Date : 2024-02-12 Samuel W. Terman, Laura Kirkpatrick, Lisa F. Akiyama, Wadih Baajour, Deniz Atilgan, Maria Kristina C. Dorotan, Hyoung Won Choi, Jacqueline A. French
The field of epilepsy has undergone substantial advances as we develop novel drugs and devices. Yet considerable challenges remain in developing broadly effective, well-tolerated treatments, but also precision treatments for rare epilepsies and seizure-monitoring devices. We summarize major recent and ongoing innovations in diagnostic and therapeutic products presented at the seventeenth Epilepsy Therapies
-
Stereo-EEG–based ictal functional connectivity in patients with periventricular nodular heterotopia–related epilepsy Epilepsia (IF 5.6) Pub Date : 2024-02-12 Marc Zanello, Elodie Garnier, Romain Carron, Aude Jegou, Stanislas Lagarde, Julia Makhalova, Samuel Medina, Christian-G. Bénar, Fabrice Bartolomei, Francesca Pizzo
Nodular heterotopia (NH)–related drug-resistant epilepsy is challenging due to the deep location of the NH and the complexity of the underlying epileptogenic network. Using ictal stereo-electroencephalography (SEEG) and functional connectivity (FC) analyses in 14 patients with NH-related drug-resistant epilepsy, we aimed to determine the leading structure during seizures. For this purpose, we compared
-
Mapping hippocampal and thalamic atrophy in epilepsy: A 7-T magnetic resonance imaging study Epilepsia (IF 5.6) Pub Date : 2024-02-12 Alfredo Lucas, Sofia Mouchtaris, Ashley Tranquille, Nishant Sinha, Ryan Gallagher, Marissa Mojena, Joel M. Stein, Sandhitsu Das, Kathryn A. Davis
Epilepsy patients are often grouped together by clinical variables. Quantitative neuroimaging metrics can provide a data-driven alternative for grouping of patients. In this work, we leverage ultra-high-field 7-T structural magnetic resonance imaging (MRI) to characterize volumetric atrophy patterns across hippocampal subfields and thalamic nuclei in drug-resistant focal epilepsy.
-
Metabolomic changes in adults with status epilepticus: A human case–control study Epilepsia (IF 5.6) Pub Date : 2024-02-10 Aurélie Hanin, Céline Chollet, Sophie Demeret, Lucas Di Meglio, Florence Castelli, Vincent Navarro
Status epilepticus (SE) is a life-threatening prolonged epileptic seizure that affects ~40 per 100 000 people yearly worldwide. The persistence of seizures may lead to excitotoxic processes, neuronal loss, and neuroinflammation, resulting in long-term neurocognitive and functional disabilities. A better understanding of the pathophysiological mechanisms underlying SE consequences is crucial for improving
-
Epilepsia – February 2024 Announcements Epilepsia (IF 5.6) Pub Date : 2024-02-13
ILAE CONGRESSES 17th Latin American Summer School on Epilepsy (LASSE XVII) 16–24 February 2024 São Paulo, Brazil 4th ILAE School on Neuropsychology in Epilepsy 3–8 March 2024 Lyon, France 6th ILAE School on EEG in the First Year of Life: From newborn to toddler 25–28 March 2024 Cambridge, UK & Online ILAE School on Neuroimaging 2024 (AMIE & SuSIE 2024) 15–18 May 2024 Potsdam, Berlin & Online XIII Congreso
-
The risk of unprovoked seizure occurrence after status epilepticus in adults Epilepsia (IF 5.6) Pub Date : 2024-02-10 Simona Lattanzi, Niccolò Orlandi, Giada Giovannini, Francesco Brigo, Eugen Trinka, Stefano Meletti
Status epilepticus (SE) may lead to long-term consequences. This study evaluated the risk and predictors of seizure occurrence after SE, with a focus on SE due to acute symptomatic etiologies.
-
Timing the clinical onset of epileptic spasms in infantile epileptic spasms syndrome: A tertiary health center's experience Epilepsia (IF 5.6) Pub Date : 2024-02-05 Aristides Hadjinicolaou, Christina Briscoe Abath, Avantika Singh, Stephanie Donatelli, Catherine L. Salussolia, Alexander Li Cohen, Jie He, Nishtha Gupta, Sabrina Merchant, Bo Zhang, Heather Olson, Christopher J. Yuskaitis, Mark H. Libenson, Chellamani Harini
Lead time to treatment (clinical onset of epileptic spasms [ES] to initiation of appropriate treatment) is known to predict outcomes in infantile epileptic spasms syndrome (IESS). Timing the clinical onset of ES is crucial to establish lead time. We investigated how often ES onset could be established to the nearest week. We aimed to (1) ascertain the exact date or estimate the nearest week of ES onset
-
Tracing topics and trends in drug-resistant epilepsy research using a natural language processing–based topic modeling approach Epilepsia (IF 5.6) Pub Date : 2024-02-05 Mert Karabacak, Pemla Jagtiani, Ankita Jain, Fedor Panov, Konstantinos Margetis
Epilepsy is a common neurological disorder affecting over 70 million people worldwide. Although many patients achieve seizure control with anti-epileptic drugs (AEDs), 30%–40% develop drug-resistant epilepsy (DRE), where seizures persist despite adequate trials of AEDs. DRE is associated with reduced quality of life, increased mortality and morbidity, and greater socioeconomic challenges. The continued
-
High-density electroencephalographic functional networks in genetic generalized epilepsy: Preserved whole-brain topology hides local reorganization Epilepsia (IF 5.6) Pub Date : 2024-02-02 André Silva Alves, Isotta Rigoni, Pierre Mégevand, Stanislas Lagarde, Fabienne Picard, Margitta Seeck, Serge Vulliémoz, Nicolas Roehri
Genetic generalized epilepsy (GGE) accounts for approximately 20% of adult epilepsy cases and is considered a disorder of large brain networks, involving both hemispheres. Most studies have not shown any difference in functional whole-brain network topology when compared to healthy controls. Our objective was to examine whether this preserved global network topology could hide local reorganizations
-
Potential merits and flaws of large language models in epilepsy care: A critical review Epilepsia (IF 5.6) Pub Date : 2024-02-02 Eric van Diessen, Ramon A. van Amerongen, Maeike Zijlmans, Willem M. Otte
The current pace of development and applications of large language models (LLMs) is unprecedented and will impact future medical care significantly. In this critical review, we provide the background to better understand these novel artificial intelligence (AI) models and how LLMs can be of future use in the daily care of people with epilepsy. Considering the importance of clinical history taking in
-
Morphometric magnetic resonance imaging (MRI) postprocessing in MRI-negative patients with first unprovoked seizure Epilepsia (IF 5.6) Pub Date : 2024-02-02 Panagiota-Eleni Tsalouchidou, Johanna Hoffmann, Sascha Strehlau, Louise Linka, Marcus Belke, Lena Habermehl, Maximilian Schulze, André Kemmling, Katja Menzler, Susanne Knake
The aim of the study was to evaluate the benefits of morphometric magnetic resonance imaging (MRI) postprocessing in patients presenting with a first seizure and negative MRI results and to investigate these findings in the context of the clinical and electroencephalographic data, seizure recurrence rates, and epilepsy diagnosis in these patients.
-
Recognition memory deficits detected through eye-tracking in well-controlled children with self-limited epilepsy with centrotemporal spikes Epilepsia (IF 5.6) Pub Date : 2024-02-01 Yanlu Fu, Jingxin Zhang, Yina Cao, Linmei Ye, Runze Zheng, Qiwei Li, Beibei Shen, Yi Shi, Jiuwen Cao, Jiajia Fang
Children with self-limited epilepsy characterized by centrotemporal spikes (SeLECTS) exhibit cognitive deficits in memory during the active phase, but there is currently a lack of studies and techniques to assess their memory development after well-controlled seizures. In this study, we employed eye-tracking techniques to investigate visual memory and its association with clinical factors and global
-
Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury Epilepsia (IF 5.6) Pub Date : 2024-01-31 Caroline G. Byington, Adam M. Goodman, Jane B. Allendorfer, Stephen Correia, W. Curt LaFrance, Jerzy P. Szaflarski
The uncinate fasciculus (UF) has been implicated previously in contributing to the pathophysiology of functional (nonepileptic) seizures (FS). FS are frequently preceded by adverse life events (ALEs) and present with comorbid psychiatric symptoms, yet neurobiological correlates of these factors remain unclear. To address this gap, using advanced diffusion magnetic resonance imaging (dMRI), UF tracts
-
EEG microstates show different features in focal epilepsy and psychogenic nonepileptic seizures Epilepsia (IF 5.6) Pub Date : 2024-01-30 Domantė Kučikienė, Ravichandran Rajkumar, Katharina Timpte, Jan Heckelmann, Irene Neuner, Yvonne Weber, Stefan Wolking
Electroencephalography (EEG) microstate analysis seeks to cluster the scalp's electric field into semistable topographical EEG activity maps at different time points. Our study aimed to investigate the features of EEG microstates in subjects with focal epilepsy and psychogenic nonepileptic seizures (PNES).
-
Topiramate ban in women of childbearing potential with idiopathic generalized epilepsy: Does effectiveness offset the teratogenic risks? Epilepsia (IF 5.6) Pub Date : 2024-01-31 Emanuele Cerulli Irelli, Enrico Cocchi, Barbara Mostacci, Biagio Orlando, Joanna Gesche, Roberto H. Caraballo, Simona Lattanzi, Gionata Strigaro, Cecilia Catania, Patrizia Pulitano, Chiara Panzini, Edoardo Ferlazzo, Angelo Pascarella, Sara Casciato, Chiara Pizzanelli, Loretta Giuliano, Veronica Viola, Francesco Fortunato, Giancarlo Di Gennaro, Antonio Gambardella, Angelo Labate, Francesca F. Operto
Regulatory agencies have recently discouraged the prescription of topiramate (TPM) to women of childbearing potential with epilepsy due to growing evidence of the teratogenic and neurodevelopmental risks associated with its use during pregnancy. It remains, however, unclear whether the use of TPM in this population can be supported to some extent by its high effectiveness. In this multicenter, retrospective
-
Predictors of therapeutic response following thalamic neuromodulation for drug-resistant pediatric epilepsy: A systematic review and individual patient data meta-analysis Epilepsia (IF 5.6) Pub Date : 2024-01-24 Akshay Sharma, Maksim Parfyonov, Jakov Tiefenbach, Olivia Hogue, Neil Nero, Lara Jehi, Demitre Serletis, William Bingaman, Ajay Gupta, Richard Rammo
We sought to perform a systematic review and individual participant data meta-analysis to identify predictors of treatment response following thalamic neuromodulation in pediatric patients with medically refractory epilepsy. Electronic databases (MEDLINE, Ovid, Embase, and Cochrane) were searched, with no language or data restriction, to identify studies reporting seizure outcomes in pediatric populations
-
Early life seizures and epileptic spasms in STXBP1-related disorders Epilepsia (IF 5.6) Pub Date : 2024-01-27 Kim M. Thalwitzer, Julie Xian, Danielle de Campo, Shridhar Parthasarathy, Jan Magielski, Katie R. Sullivan, James Goss, Charlene Son Rigby, Michael Boland, Ben Prosser, Sarah M. Ruggiero, Steffen Syrbe, Ingo Helbig
Individuals with disease-causing variants in STXBP1 frequently have epilepsy onset in the first year of life with a variety of seizure types, including epileptic spasms. However, the impact of early onset seizures and antiseizure medication (ASM) on the risk of developing epileptic spasms and impact on their trajectory are poorly understood, limiting informed and anticipatory treatment, as well as
-
Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper Epilepsia (IF 5.6) Pub Date : 2024-01-27 Emilio Perucca, Jacqueline A. French, Ghaieb Aljandeel, Simona Balestrini, Patricia Braga, Jorge G. Burneo, Augustina Charway Felli, J. Helen Cross, Aristea S. Galanopoulou, Satish Jain, Yuwu Jiang, Reetta Kälviäinen, Shih Hui Lim, Kimford J. Meador, Zarine Mogal, Rima Nabbout, Francesca Sofia, Ernest Somerville, Michael R. Sperling, Chahnez Triki, Eugen Trinka, Matthew C. Walker, Samuel Wiebe, Jo
A variety of terms, such as “antiepileptic,” “anticonvulsant,” and “antiseizure” have been historically applied to medications for the treatment of seizure disorders. Terminology is important because using terms that do not accurately reflect the action of specific treatments may result in a misunderstanding of their effects and inappropriate use. The present International League Against Epilepsy (ILAE)
-
Low prevalence of neural autoantibodies in perioperative cerebrospinal fluid samples of epilepsy surgery patients: A multicenter prospective study Epilepsia (IF 5.6) Pub Date : 2024-01-27 Hana Mojžišová, Martin Elišák, David Krýsl, Jitka Hanzalová, Adam Kalina, Marko Petržalka, Irena Doležalová, Matěj Červenka, Barbora Cvičková, Robert Leško, Jan Šroubek, Daniela Sochůrková, Jan Hemza, Eva Brichtová, Justina Dargvainiene, Zdeněk Vojtěch, Milan Brázdil, Klaus-Peter Wandinger, Frank Leypoldt, Petr Marusič
Refractory epilepsy may have an underlying autoimmune etiology. Our aim was to assess the prevalence of neural autoantibodies in a multicenter national prospective cohort of patients with drug-resistant epilepsy undergoing epilepsy surgery utilizing comprehensive clinical, serologic, and histopathological analyses.