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Neural circuits for retrospective and prospective introspection for the past, present and future in macaque monkeys and humans Neurosci. Res. (IF 2.9) Pub Date : 2024-03-08 K, e, n, t, a, r, o, , M, i, y, a, m, o, t, o
For animals, including humans, to have self-awareness, the ability to reflect on one's own perceptions and cognitions, which is known as metacognition, and an understanding of consistency of the self from the past to the present and into the future based on metacognition is essential. Through the mediation of self-consciousness, animals are thought to be able to proactively act to change their environment
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Fatty acid amides present in Camembert cheese improved cognitive decline after oral administration in mice Neurosci. Res. (IF 2.9) Pub Date : 2024-03-07 Kohei Kawano, Maiko Shobako, Taichi Furukawa, Tatsuhiro Toyooka, Kousaku Ohinata
Herein, we investigated the effects of Camembert cheese (CC) and its fatty acid contents on cognitive function in mice by employing the object recognition test to evaluate hippocampus-dependent memory. Orally administered CC improved the cognitive decline induced by a high-fat diet. Next, we focused on myristamide (MA), oleamide, and stearamide, which are fatty acid amides produced during the fermentation
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Retinal vascular pathology in a mouse model of Lafora progressive myoclonus epilepsy Neurosci. Res. (IF 2.9) Pub Date : 2024-03-06 Ruchira Pranay Patil, Nitin Kumar, Arveen Kaur, Rajendra Kumar Munian, Bishakh Bhattacharya, Subramaniam Ganesh, Rashmi Parihar
Neurodegenerative diseases (ND) affect distinct populations of neurons and manifest various clinical and pathological symptoms. A subset of ND prognoses has been linked to vascular risk factors. Consequently, the current study investigated retinal vascular abnormalities in a murine model of Lafora neurodegenerative disease (LD), a fatal and genetic form of progressive myoclonus epilepsy that affects
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Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with sweetener consumption in mice Neurosci. Res. (IF 2.9) Pub Date : 2024-02-15 Shaolei Jiang, Bo Song, Zhongdong Liu, Shuifa Shen, Weiliang Qian, Jing Sun, Gaowei Chen, Yingjie Zhu
Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD), high sucrose diet (HSD), high stevioside
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Decision-making ability limitations and brain neural activity changes in healthcare workers after mild COVID-19 Neurosci. Res. (IF 2.9) Pub Date : 2024-02-12 Yaotian Gao, Keyi Lin, Bangyue Wang, Wei Ji, Jia Liu, Mengcheng Du, Wei Wang, Yan Li, Xiaowen Du, Yuyang Wang, Tao Jiang
Studies have demonstrated that the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) extensively affects brain function. Although cognitive dysfunction is considered a common manifestation in COVID-19 patients during the recovery period, the potential changes in decision-making ability, are not yet clear. Decision-making functions are essential to the work of healthcare workers. However
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The cognitive reality monitoring network and theories of consciousness Neurosci. Res. (IF 2.9) Pub Date : 2024-02-03 Aurelio Cortese, Mitsuo Kawato
Theories of consciousness abound. However, it is difficult to arbitrate reliably among competing theories because they target different levels of neural and cognitive processing or anatomical loci, and only some were developed with computational models in mind. In particular, theories of consciousness need to fully address the three levels of understanding of the brain proposed by David Marr: computational
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Revisiting the blind mind: still no evidence for sensory visual imagery in individuals with aphantasia Neurosci. Res. (IF 2.9) Pub Date : 2024-02-02 Rebecca Keogh, Joel Pearson
The inability to visualise was given the name aphantasia in 2015 by Zeman and colleagues. In 2018 we published research showing that fifteen individuals who self-identified as having aphantasia also demonstrated a lack of sensory visual imagery when undergoing the binocular rivalry imagery paradigm, suggesting more than just a metacognitive difference. Here we update these findings with over fifty
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Anxiety control by astrocytes in the lateral habenula Neurosci. Res. (IF 2.9) Pub Date : 2024-02-02 Wanqin Tan, Yoko Ikoma, Yusuke Takahashi, Ayumu Konno, Hirokazu Hirai, Hajime Hirase, Ko Matsui
The potential role of astrocytes in lateral habenula (LHb) in modulating anxiety was explored in this study. The habenula are a pair of small nuclei located above the thalamus, known for their involvement in punishment avoidance and anxiety. Herein, we observed an increase in theta-band oscillations of local field potentials (LFPs) in the LHb when mice were exposed to anxiety-inducing environments
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New ways of studying subjective experience Neurosci. Res. (IF 2.9) Pub Date : 2024-02-01 Rebecca Keogh, Hakwan Lau
Abstract not available
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Characterization of pathological stages in a mouse model of progressive multiple sclerosis Neurosci. Res. (IF 2.9) Pub Date : 2024-02-01 Satoshi Hamano, Toshiki Yoshimizu, Mutsuki Mori, Akio Iida, Toshihide Yamashita
The purpose of this study was to analyze and elucidate the mechanisms of non-obese diabetes-experimental autoimmune encephalomyelitis (NOD-EAE), an animal model of progressive multiple sclerosis (MS), and to compare the pathological features with those observed in human progressive MS. Pathological analysis, flow cytometry analysis, immunohistochemical staining, and transcriptome analysis were performed
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Pro-neuroinflammatory and neurotoxic potential of extracellular histones H1 and H3 Neurosci. Res. (IF 2.9) Pub Date : 2024-01-24 Seamus A. McRae, Christy M. Richards, Dylan E. Da Silva, Ishvin Riar, Sijie (Shirley) Yang, Noah E. Zurfluh, Julien Gibon, Andis Klegeris
Histones organize DNA within cellular nuclei, but they can be released from damaged cells. In peripheral tissues extracellular histones act as damage-associated molecular patterns (DAMPs) inducing pro-inflammatory activation of immune cells. Limited studies have considered DAMP-like activity of histones in the central nervous system (CNS); therefore, we studied the effects of extracellular histones
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Primary Somatosensory Cortex Organization for Engineering Artificial Somatosensation Neurosci. Res. (IF 2.9) Pub Date : 2024-01-24 Krista Lamorie-Foote, Daniel R. Kramer, Shivani Sundaram, Jonathon Cavaleri, Zachary D. Gilbert, Austin M. Tang, Luke Bashford, Charles Y. Liu, Spencer Kellis, Brian Lee
Somatosensory deficits from stroke, spinal cord injury, or other neurologic damage can lead to a significant degree of functional impairment. The primary (SI) and secondary (SII) somatosensory cortices encode information in a medial to lateral organization. SI is generally organized topographically, with more discrete cortical representations of specific body regions. SII regions corresponding to anatomical
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Relationships of Brain Cholesterol and Cholesterol Biosynthetic Enzymes to Alzheimer’s Pathology and Dementia in the CFAS Population-Derived Neuropathology Cohort Neurosci. Res. (IF 2.9) Pub Date : 2024-01-24 H Mistry, CD Richardson, A Higginbottom, Bridget Ashford, Saif U Ahamed, Zoe Moore, FE Matthews, C Brayne, JE Simpson, SB Wharton
Altered cholesterol metabolism is implicated in brain ageing and Alzheimer’s disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer’s disease neuropathological change (ADNC). Temporal cortex (n=99) was obtained from the Cognitive Function and Ageing Study. Expression of the cholesterol biosynthesis rate-limiting
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Neural Activity Related to Productive Vocabulary Knowledge Effects during Second Language Comprehension Neurosci. Res. (IF 2.9) Pub Date : 2024-01-18 Takara Kenza Allal-Sumoto, Duygu Şahin, Hiroaki Mizuhara
Second language learners and educators often believe that improving one’s listening ability hinges on acquiring an extensive vocabulary and engaging in thorough listening practice. Our previous study suggested that listening comprehension is also impacted by the ability to produce vocabulary. Nevertheless, it remained uncertain whether quick comprehension could be attributed to a simple acceleration
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Late-spiking retrosplenial cortical neurons are not synchronized with neocortical slow waves in anesthetized mice Neurosci. Res. (IF 2.9) Pub Date : 2024-01-14 Hiroyuki Mizuno, Yuji Ikegaya
Neocortical slow waves are critical for memory consolidation. The retrosplenial cortex is thought to facilitate the slow wave propagation to regions beyond the neocortex. However, it remains unclear which population is responsible for the slow wave propagation. To address this issue, we performed in vivo whole-cell recordings to identify neurons that were synchronous and asynchronous with slow waves
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Structural connectivity of the precuneus and its relation to resting-state networks Neurosci. Res. (IF 2.9) Pub Date : 2023-12-30 Atsushi Yamaguchi, Tatsuya Jitsuishi
The precuneus is an association area in the posteromedial cortex (PMC) that is involved in high-order cognitive functions through integrating multi-modal information. Previous studies have shown that the precuneus is functionally heterogeneous and subdivided into several subfields organized by the anterior-posterior and ventral-dorsal axes. Further, the precuneus forms the structural core of brain
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The therapeutic role of SSEA3(+) human umbilical cord blood mononuclear cells in ischemic stroke model Neurosci. Res. (IF 2.9) Pub Date : 2023-12-26 Dongjie Xiao, Fang Li, Kun Zhang, Guojun Liu, Yunshan Wang, Hua Liu
Numerous evidences showed that human umbilical cord blood (UCB) mononuclear cells were a promising approach for the therapy of ischemic stroke(IS). The effect of stage-specific embryonic antigen 3 (SSEA3)positive subpopulation in UCB was not investigated in IS. In this study, we isolated SSEA3 positive cells from healthy UCB mononuclear cells, which comprised about 7.01% of the total UCB-mononuclear
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Two common issues in synchronized multimodal recordings with EEG: Jitter and Latency Neurosci. Res. (IF 2.9) Pub Date : 2023-12-22 Seitaro Iwama, Mitsuaki Takemi, Ryo Eguchi, Ryotaro Hirose, Masumi Morishige, Junichi Ushiba
Multimodal recording using electroencephalogram (EEG) and other biological signals (e.g., muscle activities, eye movement, pupil diameters, or body kinematics data) is ubiquitous in human neuroscience research. However, the precise time alignment of multiple data from heterogeneous sources (i.e., devices) is often arduous due to variable recording parameters of commercially available research devices
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A Comparative Overview of DSCAM and its Multifunctional Roles in Drosophila and Vertebrates Neurosci. Res. (IF 2.9) Pub Date : 2023-12-21 Kento Hizawa, Takuya Sasaki, Nariko Arimura
DSCAM (Down syndrome cell adhesion molecule) is a unique neuronal adhesion protein with extensively documented multifaceted functionalities. And DSCAM has interesting properties in vertebrates and invertebrates, respectively. Particularly, in Drosophila species, Dscam exhibits remarkable genetic diversity, with tens of thousands of splicing isoforms that modulate the specificity of neuronal wiring
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Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP1 Neurosci. Res. (IF 2.9) Pub Date : 2023-12-16 Masaki Nakano, Tomohiro Tsuchida, Yachiyo Mitsuishi, Masaki Nishimura
Epidemiological studies have shown that cigarette smoking increases the risk of Alzheimer disease. However, inconsistent results have been reported regarding the effects of smoking or nicotine on brain amyloid β (Aβ) deposition. In this study, we found that stimulation of the nicotinic acetylcholine receptor (nAChR) increased Aβ production in mouse brains and cultured neuronal cells. nAChR activation
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Unveiling the Regulatory of miR-101-3p on ZNF746 in a Parkinson's Disease Cell Model: Implications for Therapeutic Targeting Neurosci. Res. (IF 2.9) Pub Date : 2023-12-14 Maryam Mahmoudian Esfahani, Maryam Mostashfi, Shiva Vaheb Hosseinabadi, Motahare-Sadat Hashemi, Maryam Peymani, Dina Zohrabi, Seyed Abdolhamid Angaji, Mohammad Hossein Nasr-Esfahani, Kamran Ghaedi
In this study, we explored the regulatory role of microRNA miR-101-3p on the zinc finger protein 746 (ZNF746), also known as PARIS, which is implicated in both sporadic and familial forms of Parkinson's disease. In a Parkinson's disease cell model, utilizing SH-SY5Y cells treated with 1-methyl-4-phenylpyridine (MPP+), we observed that miR-101-3p was downregulated, while ZNF746 was upregulated. To investigate
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Contribution of the retrosplenial cortex to route selection in a complex maze Neurosci. Res. (IF 2.9) Pub Date : 2023-12-01 Tomohiro Hayashi, Nobuya Sato
The retrosplenial cortex (RSC) is a region involved in navigation. In this study, we investigated the role of the RSC in navigation in a large-scale environment where the destination is not visible from the current location. We used a large maze where the routes could be freely designed by inserting and removing plates. In Experiment 1, rats learned a specific route in the maze and then were tested
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Microglia modulate sleep/wakefulness under baseline conditions and under acute social defeat stress in adult mice Neurosci. Res. (IF 2.9) Pub Date : 2023-11-27 Kazuya Miyanishi, Noriko Hotta-Hirashima, Chika Miyoshi, Satsuki Hayakawa, Miyo Kakizaki, Satomi Kanno, Aya Ikkyu, Hiromasa Funato, Masashi Yanagisawa
Although sleep is tightly regulated by multiple neuronal circuits in the brain, nonneuronal cells such as glial cells have been increasingly recognized as crucial sleep regulators. Recent studies have shown that microglia may act to maintain wakefulness. Here, we investigated the possible involvement of microglia in the regulation of sleep quantity and quality under baseline and stress conditions through
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Multisensory subtypes of aphantasia: Mental imagery as supramodal perception in reverse Neurosci. Res. (IF 2.9) Pub Date : 2023-11-27 Alexei Joel Dawes, Rebecca Keogh, Joel Pearson
Cognitive neuroscience research on mental imagery has largely focused on the visual imagery modality in unimodal task contexts. Recent studies have uncovered striking individual differences in visual imagery capacity, with some individuals reporting a subjective absence of conscious visual imagery ability altogether (“aphantasia”). However, naturalistic mental imagery is often multi-sensory, and preliminary
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Glial tone of aggression Neurosci. Res. (IF 2.9) Pub Date : 2023-11-24 Yuki Asano, Daichi Sasaki, Yoko Ikoma, Ko Matsui
Anger transition is often abrupt. In this study, we investigated the mechanisms responsible for switching and modulating aggression levels. The cerebellum is considered a center for motor coordination and learning; however, its connection to social behavior has long been observed. Here, we used the resident-intruder paradigm in male mice and examined local field potential (LFP) changes, glial cytosolic
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Reality monitoring and metacognitive judgments in a false-memory paradigm Neurosci. Res. (IF 2.9) Pub Date : 2023-11-23 Saurabh Ranjan, Brian Odegaard
How well do we distinguish between different memory sources when the information from imagination and perception is similar? And how do metacognitive (confidence) judgments differ across different sources of experiences? To study these questions, we developed a reality monitoring task using semantically related words from the Deese-Roediger-McDermott (DRM) paradigm of false memories. In an orientation
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Peripheral vision is mainly for looking rather than seeing Neurosci. Res. (IF 2.9) Pub Date : 2023-11-22 Li Zhaoping
Vision includes looking and seeing. Looking, mainly via gaze shifts, selects a fraction of visual input information for passage through the brain’s attentional bottleneck. The selected input is placed within the attentional spotlight, typically in the central visual field. Seeing decodes, i.e., recognizes and discriminates, the selected inputs. Hence, peripheral vision should be mainly devoted to looking
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The blues and rhythm Neurosci. Res. (IF 2.9) Pub Date : 2023-11-22 Kiyomichi Imamura, Ayaka Bota, Toshihiko Shirafuji, Toru Takumi
Most organisms, including humans, show daily rhythms in many aspects of physiology and behavior, and abnormalities in the rhythms are potential risk factors for various diseases. Mood disorders such as depression are no exception. Accumulating evidence suggests strong associations between circadian disturbances and the development of depression. Numerous studies have shown that interventions to circadian
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Early life stress and altered social behaviors: a perspective across species Neurosci. Res. (IF 2.9) Pub Date : 2023-11-20 Lyonna F. Parise, C. Joseph Burnett, Scott J. Russo
Childhood and adolescent affiliations guide how individuals engage in social relationships throughout their lifetime and adverse experiences can promote biological alterations that facilitate behavioral maladaptation. Indeed, childhood victims of abuse are more likely to be diagnosed with conduct or mood disorders which are both characterized by altered social engagement. A key domain particularly
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Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats Neurosci. Res. (IF 2.9) Pub Date : 2023-11-08 Harue Yanagimura, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiya
Gabapentinoids are used worldwide as first-line agents for the treatment of neuropathic pain. Accumulating evidence indicates that one of the antihyperalgesic mechanisms of gabapentinoids is through activation of the noradrenergic pathway of the descending pain inhibition system. However, the involvement of the serotonin pathway is unclear. We investigated the effects of gabapentin (GBP) on the serotonergic
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Disrupted interoceptive awareness by auditory distractor: Difficulty inferring the internal bodily states? Neurosci. Res. (IF 2.9) Pub Date : 2023-11-05 Yusuke Haruki, Kenji Ogawa
Recent studies have associated interoceptive awareness, the perception of internal bodily sensations, with a predictive mechanism of perception across all sensory modalities. According to the framework, volitional attention plays a pivotal role in interoceptive awareness by prioritizing interoceptive sensations over exteroceptive ones. Consequently, it is hypothesized that the presence of irrelevant
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Exogenous neuritin restores auditory following cochlear spiral ganglion neuron denervation of gerbils Neurosci. Res. (IF 2.9) Pub Date : 2023-11-04 Gui Fei, Song Dandan, Wang Haiyan, Zhang Shuai, Sun Xiaopin, Hong Yu, Yang Yi, Chen Rong, Huang Jin, Song Xiaoming, Yang Lei
Spiral ganglion neurons (SGNs) transmit sound signals received by hair cells to the auditory center to produce hearing. The quantity and function are important for maintaining normal hearing function. Limited by the regenerative capacity, SGNs are unable to regenerate spontaneously after injury. Various neurotrophic factors play an important role in the regeneration process. Neuritin is a neurite growth
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Targeted upregulation of dMyc restricts JNK-mediated degeneration of dopaminergic neurons in the paraquat-induced Parkinson’s disease model of Drosophila Neurosci. Res. (IF 2.9) Pub Date : 2023-10-31 , Surajit Sarkar
Parkinson’s disease is the second most common neurodegenerative disease characterized by the loss of dopaminergic neurons in the brain. Parkinson’s disease has both familial and sporadic cases of origin governed differentially by genetic and/or environmental factors. Different epidemiological studies have proposed an association between the pathogenesis of cancer and Parkinson’s disease; however, a
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Distinct subdivisions of subcortical U-fiber regions in the gyrencephalic ferret brain Neurosci. Res. (IF 2.9) Pub Date : 2023-10-20 Mayuko Yoshino, Yoshitake Shiraishi, Kengo Saito, Narufumi Kameya, Toshihide Hamabe-Horiike, Yohei Shinmyo, Mitsutoshi Nakada, Noriyuki Ozaki, Hiroshi Kawasaki
The human cerebrum contains a large amount of cortico-cortical association fibers. Among them, U-fibers are short-range association fibers located in white matter immediately deep to gray matter. Although U-fibers are thought to be crucial for higher cognitive functions, the organization within U-fiber regions are still unclear. Here we investigated the properties of U-fiber regions in the ferret cerebrum
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Mechanisms of axonal degeneration and regeneration of the nervous system Neurosci. Res. (IF 2.9) Pub Date : 2023-10-14 Miki Otsuki, Marco Terenzio
Abstract not available
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Analysis of splicing abnormalities in the white matter of myotonic dystrophy type 1 brain using RNA sequencing Neurosci. Res. (IF 2.9) Pub Date : 2023-10-06 Kazuki Yoshizumi, Masamitsu Nishi, Masataka Igeta, Masayuki Nakamori, Kimiko Inoue, Tsuyoshi Matsumura, Harutoshi Fujimura, Kenji Jinnai, Takashi Kimura
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by the genomic expansion of CTG repeats, in which RNA-binding proteins, such as muscleblind-like protein, are sequestered in the nucleus, and abnormal splicing is observed in various genes. Although abnormal splicing occurs in the brains of patients with DM1, its relation to central nervous system symptoms is unknown. Several imaging
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Transsynaptic activation of human lumbar spinal motoneurons by transvertebral magnetic stimulation Neurosci. Res. (IF 2.9) Pub Date : 2023-10-02 Kazutake Kawai, Toshiki Tazoe, Toshimasa Yanai, Kanosue Kazuyuki, Yukio Nishimura
Noninvasive spinal stimulation has been increasingly used in research on motor control and neurorehabilitation. Despite advances in percutaneous electrical stimulation techniques, magnetic stimulation is not as commonly used as electrical stimulation. Therefore, it is still under discussion what neuronal elements are activated by magnetic stimulation of the human spinal cord. In this study, we demonstrated
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Effects of Sleep Deprivation on Sleep and Sleep Electroencephalogram in Secretin-receptor Knockout Mice Neurosci. Res. (IF 2.9) Pub Date : 2023-09-27 Moridera Aiko, Fujihara Hiroaki, Cherasse Yoan, Mugishima Go, Fujiki Nobuhiro
Recent studies has consistently demonstrated a relationship between secretin and autism-like behavior in mice. Therefore, secretin-receptor knockout (SCTR-KO) mice are used to study autism. However, with respect to humans, some studies have reported that secretin administration could improve autistic symptoms in contrast to other studies. A consistent finding revealed that several patients with autism
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Purposive Decision-making Task in Mice Using Touchscreen Operant Apparatus Neurosci. Res. (IF 2.9) Pub Date : 2023-09-25 Takeru Suzuki, Daisuke Joho, Masaki Kakeyama
Purposive decision-making, based on sensory input and memory, is a component of executive functioning. Evaluating executive functioning is crucial for understanding neuropsychiatric disorders and brain injuries. However, there's a lack of mouse tests for this purpose. To address this, we developed a novel touchscreen task to assess purposive decision-making in mice. In the present task, the mice had
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SUMOylation effects on neural stem cells self-renewal, differentiation, and survival Neurosci. Res. (IF 2.9) Pub Date : 2023-09-22 Letícia Yoshitome Queiroz, Ryoichiro Kageyama, Helena I. Cimarosti
SUMO (small ubiquitin-like modifier) conjugation or SUMOylation, a post-translational modification, is a crucial regulator of protein function and cellular processes. In the context of neural stem cells (NSCs), SUMOylation has emerged as a key player, affecting their proliferation, differentiation, and survival. By modifying transcription factors, such as SOX1, SOX2, SOX3, SOX6, Bmi1, and Nanog, SUMOylation
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BMSC-derived exosomal miR-148b-3p attenuates OGD/R-induced HMC3 cell activation by targeting DLL4 and Notch1 Neurosci. Res. (IF 2.9) Pub Date : 2023-09-21 Fang Yi, Hui Xiao, Mingyu Song, Lei Huang, Qianyi Huang, Jun Deng, Han Yang, Lan Zheng, Hong Wang, Wenping Gu
Bone mesenchymal stem cell (BMSC)-derived exosome (BMSC-Exo) could be a treatment method for ischemic injury. In ischemic cerebrovascular disease (IC), microglia is pivotal in neuronal damage and remodeling. This study explores the mechanisms of BMSC-Exo miR-148b-3p in regulating oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human microglial clone 3 (HMC3) cell activation. Transmission electron
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Number of kinesins engaged in axonal cargo transport: A novel biomarker for neurological disorders Neurosci. Res. (IF 2.9) Pub Date : 2023-09-19 Kumiko Hayashi, Kazuo Sasaki
Kinesin motor proteins play crucial roles in anterograde transport of cargo vesicles in neurons, moving them along axons from the cell body towards the synaptic region. Not only the transport force and velocity of single motor protein, but also the number of kinesin molecules involved in transporting a specific cargo, is pivotal for synapse formation. This collective transport by multiple kinesins
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How to study subjective experience in an animal model of blindsight? Neurosci. Res. (IF 2.9) Pub Date : 2023-09-09 Xiyao Yu, Reona Yamaguchi, Tadashi Isa
The nature of subjective conscious experience, which accompanies us throughout our waking lives, and how it is generated, remain elusive. One of the challenges in studying subjective experience is disentangling the brain activity related to the sensory stimulus processing and stimulus-guided behavior from those associated with subjective perception. Blindsight, a phenomenon characterized by the retained
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Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdala Neurosci. Res. (IF 2.9) Pub Date : 2023-09-09 Emi Hasegawa, Yulong Li, Takeshi Sakurai
Animals have a sleep cycle that involves the repetitive occurrence of non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. In a previous study, we discovered that a transient increase in dopamine (DA) levels in the basolateral amygdala (BLA) during NREM sleep terminates NREM sleep and initiates REM sleep by acting on Drd2-positive neurons (Hasegawa et al., 2022). In this study, we
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Protein biomarkers for the diagnosis and prognosis of Amyotrophic Lateral Sclerosis Neurosci. Res. (IF 2.9) Pub Date : 2023-09-07 Luisa Donini, Raffaella Tanel, Riccardo Zuccarino, Manuela Basso
Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease, still incurable. The disease is highly heterogenous both genetically and phenotypically. Therefore, developing efficacious treatments is challenging in many aspects because it is difficult to predict the rate of disease progression and stratify the patients to minimize statistical variability in clinical studies. Moreover
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Super-resolution imaging reveals the relationship between CaMKIIβ and drebrin within dendritic spines Neurosci. Res. (IF 2.9) Pub Date : 2023-09-01 Hiroyuki Yamazaki, Noriko Koganezawa, Hideaki Yokoo, Yuko Sekino, Tomoaki Shirao
Dendritic spines are unique postsynaptic structures that emerge from the dendrites of neurons. They undergo activity-dependent morphological changes known as structural plasticity. The changes involve actin cytoskeletal remodeling, which is regulated by actin-binding proteins. CaMKII is a crucial molecule in synaptic plasticity. Notably, CaMKIIβ subtype is known to bind to filamentous-actin and is
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Exendin-4 increases the firing activity of hippocampal CA1 neurons through TRPC4/5 channels Neurosci. Res. (IF 2.9) Pub Date : 2023-08-16 Hui-Zhe Sun, Fang-Shuai Shen, Xiao-Xue Li, Cui Liu, Yan Xue, Xiao-Hua Han, Xin-Yi Chen, Lei Chen
The central neuropeptide GLP-1 is synthesized by preproglucagon (PPG) neurons in the brain. GLP-1 receptors are widely distributed in central nervous system. Hippocampus is a key component of the limbic system which is involved in learning, memory, and cognition. Previous studies have shown that overexpression of GLP-1 receptors in the hippocampus could improve the process of learning and memory. However
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Prediction error in dopamine neurons during associative learning Neurosci. Res. (IF 2.9) Pub Date : 2023-07-13 Ryunosuke Amo
Dopamine neurons have long been thought to facilitate learning by broadcasting reward prediction error (RPE), a teaching signal used in machine learning, but more recent work has advanced alternative models of dopamine’s computational role. Here, I revisit this critical issue and review new experimental evidences that tighten the link between dopamine activity and RPE. First, I introduce the recent
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A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels Neurosci. Res. (IF 2.9) Pub Date : 2023-07-11 Qiyun Kang, Ziting Zhu, Zhongrui Liu, Fei Li, Yan He, Yaru Yang, Xutao Wang, Shuisheng Lei, Zishu Yuan, Xiaoqin Zhu
Epilepsy is a common neurological disorder worldwide. Hydrogen sulfide (H2S) has been found to have anti-seizure effects. However, its mechanism remains to be explored. In the present study, we showed that a novel H2S donor attenuated neuroinflammation by up-regulating ATP-sensitive potassium channel (KATP) expression to reduce seizures. The novel H2S donor significantly reduced the expression of TNF-α
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Temporal and quantitative analysis of the functional expression of Ca2+-permeable AMPA receptors during LTP Neurosci. Res. (IF 2.9) Pub Date : 2023-07-08 Yoshihiko Wakazono, Ryosuke Midorikawa, Kogo Takamiya
In the present study, we attempted to temporally and quantitatively analyze the functional contributions of Ca2+-permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) during long-term potentiation (LTP) expression using electrophysiological and pharmacological approaches. In hippocampal CA1 neurons, using 1-naphthyl acetyl spermine (NASPM), a CP-AMPAR antagonist, we
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Perinatal ethanol exposure affects cell populations in adult dorsal hippocampal neurogenic niche Neurosci. Res. (IF 2.9) Pub Date : 2023-07-05 Nerina M. Villalba, Catalina Madarnas, Julieta Bressano, Viviana Sanchez, Alicia Brusco
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Increased nociceptive behaviors and spinal c-Fos expression in the formalin test in a rat repeated cold stress model Neurosci. Res. (IF 2.9) Pub Date : 2023-06-29 Teruaki Nasu, Riku Kainuma, Hiroki Ota, Kazue Mizumura, Toru Taguchi
Repeated cold stress (RCS) can trigger the development of fibromyalgia (FM)-like symptoms, including persistent deep-tissue pain, although nociceptive changes to the skin have not been fully characterized. Using a rat RCS model, we investigated nociceptive behaviors induced by noxious mechanical, thermal, and chemical stimuli applied to plantar skin. Neuronal activation in the spinal dorsal horn was
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Prolonged stress-induced depression-like behaviors in aged rats are mediated by endoplasmic reticulum stress and apoptosis in the hippocampus Neurosci. Res. (IF 2.9) Pub Date : 2023-06-29 Arshad Ghaffari-Nasab, Gonja Javani, Hadi Yousefi, Rahim Sharafkhani, Sajjad Taghizadeh
Structural and functional recovery from stress-induced depression is impaired in the context of aging brain. Since investigating the molecular substrates that facilitate behavioral recovery may have important implications for understanding brain plasticity and resilience of individuals, we studied depressive-like behaviors in young and aged rats 6 weeks after chronic stress exposure as a recovery period