样式: 排序: IF: - GO 导出 标记为已读
-
MRI brain structural and functional networks changes in Parkinson disease with REM sleep behavior disorders Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-15 Fang Wang, Zhigang Zhu, Chuanbin Zhou, Yongyun Zhu, Yangfan Zhu, Chunyu Liang, Jieyu Chen, Bin Liu, Hui Ren, Xinglong Yang
BackgroundRapid eye movement sleep behavior disorder (RBD) is common in individuals with Parkinson’s disease (PD). In spite of that, the precise mechanism underlying the pathophysiology of RBD among PD remains unclear.ObjectiveThe aim of the present study was to analyze gray matter volumes (GMVs) as well as the changes of functional connectivity (FC) among PD patients with RBD (PD-RBD) by employing
-
Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-15 Alejandro Lomniczi, Selva L. Luna, Rita Cervera-Juanes, Maria-Luisa Appleman, Steven G. Kohama, Henryk F. Urbanski
IntroductionThe hippocampus is especially susceptible to age-associated neuronal pathologies, and there is concern that the age-associated rise in cortisol secretion from the adrenal gland may contribute to their etiology. Furthermore, because 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) catalyzes the reduction of cortisone to the active hormone cortisol, it is plausible that an increase in the
-
Executive and memory dysfunction related to binge drinking in stroke survivors during a 9-year follow-up Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-15 Siiri Laari, Tatu Kauranen, Katri Turunen, Satu Mustanoja, Turgut Tatlisumak, Erja Poutiainen
BackgroundIschemic stroke and heavy alcohol consumption are both known risk factors for cognitive impairment. The issue gains importance because the prevalence of stroke and binge drinking have both increased among working-aged adults. Alarmingly, a recent cross-sectional study suggests the additive negative effects of binge drinking and comorbid brain disease on cognition. However, the long-term cognitive
-
Automatic assessment of disproportionately enlarged subarachnoid-space hydrocephalus from 3D MRI using two deep learning models Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-15 Shigeki Yamada, Hirotaka Ito, Hironori Matsumasa, Satoshi Ii, Tomohiro Otani, Motoki Tanikawa, Chifumi Iseki, Yoshiyuki Watanabe, Shigeo Wada, Marie Oshima, Mitsuhito Mase
BackgroundDisproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a key feature for Hakim disease (idiopathic normal pressure hydrocephalus: iNPH), but subjectively evaluated. To develop automatic quantitative assessment of DESH with automatic segmentation using combined deep learning models.MethodsThis study included 180 participants (42 Hakim patients, 138 healthy volunteers; 78 males
-
Association between dietary inflammatory index and cognitive impairment among American elderly: a cross-sectional study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-14 Yu Zhang, Yuanyuan Peng, Wei Deng, Qian Xiang, Wang Zhang, Maohang Liu
BackgroundIt has been shown that inflammation may be associated with cognitive impairment (CI). Diet modulates inflammation. However, there is currently a scarcity of epidemiological studies exploring the connection between the inflammatory potential of diet and CI. The objective was to investigate the correlation between the dietary inflammatory index (DII) and cognitive impairment in older adults
-
Aging effects on the encoding/retrieval flip in associative memory: fMRI evidence from incidental contingency learning Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-13 Else Schneider, Marko Rajkovic, Rudolf Krug, Marco P. Caviezel, Carolin F. Reichert, Oliver Bieri, André Schmidt, Stefan Borgwardt, Thomas Leyhe, Christoph Linnemann, Annette B. Brühl, Undine E. Lang, Tobias Melcher
IntroductionAssociative memory is arguably the most basic memory function and therein constitutes the foundation of all episodic and semantic memory processes. At the same time, the decline of associative memory represents a core feature of age-related cognitive decline in both, healthy and pathological (i.e., dementia-related) aging. The neural mechanisms underlying age-related impairments in associative
-
Analyzing changes in parkinsonian speech over time: a diachronic experimental phonetics study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-12 Massimo Pettorino, Marta Maffia
In this contribution the use of web resources for the longitudinal study of speech rhythm of a ‘well-known’ person diagnosed with Parkinson’s disease, the American actor Alan Alda, is proposed. A corpus of 20 speech samples produced in the period between 1979 and 2021 was collected from the web. A rhythmical analysis was conducted, based on two parameters: the percentage of vocalic portion on the total
-
Physical exercise frequency and cognition: a multicenter cross-sectional cohort study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-08 Chen Wen, Jing-Huan Gan, Guo-Wei Huang, Xiao-Dan Wang, Yang Lü, Jian-Ping Niu, Xin-Ling Meng, Pan Cai, Yang Li, Bao-Zhi Gang, Yong You, Yan Lv, Zhi-Hong Ren, Shuai Liu, Yan Zeng, Yong Ji
Background and aimsDementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency of physical exercise (physical exercise), we investigated the association between frequency of PE and cognition in Chinese old adults.Methods16,181 Chinese participants
-
Exploring the application and challenges of fNIRS technology in early detection of Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-08 Pengsheng Hui, Yu Jiang, Jie Wang, Congxiao Wang, Yingqi Li, Boyan Fang, Hujun Wang, Yingpeng Wang, Shuyan Qie
BackgroundParkinson’s disease (PD) is a prevalent neurodegenerative disorder that significantly benefits from early diagnosis for effective disease management and intervention. Despite advancements in medical technology, there remains a critical gap in the early and non-invasive detection of PD. Current diagnostic methods are often invasive, expensive, or late in identifying the disease, leading to
-
Regional covariance of white matter hyperintensity volume patterns associated with hippocampal volume in healthy aging Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-08 Emily J. Van Etten, Pradyumna K. Bharadwaj, Matthew D. Grilli, David A. Raichlen, Georg A. Hishaw, Matthew J. Huentelman, Theodore P. Trouard, Gene E. Alexander
Hippocampal volume is particularly sensitive to the accumulation of total brain white matter hyperintensity volume (WMH) in aging, but how the regional distribution of WMH volume differentially impacts the hippocampus has been less studied. In a cohort of 194 healthy older adults ages 50–89, we used a multivariate statistical method, the Scaled Subprofile Model (SSM), to (1) identify patterns of regional
-
Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-07 Marcelo Febo, Rohit Mahar, Nicholas A. Rodriguez, Joy Buraima, Marjory Pompilus, Aeja M. Pinto, Matteo M. Grudny, Adriaan W. Bruijnzeel, Matthew E. Merritt
IntroductionThe differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have been reported, but the functional neural circuitry warrants further investigation.MethodsWe assessed age variations in affective behaviors and functional connectivity
-
Mitigating cellular aging and enhancing cognitive functionality: visual arts-mediated Cognitive Activation Therapy in neurocognitive disorders Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-07 Manuela Campisi, Luana Cannella, Dilek Celik, Carlo Gabelli, Donata Gollin, Marco Simoni, Cristina Ruaro, Elena Fantinato, Sofia Pavanello
The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological aging [leukocyte telomere length (LTL), DNA methylation
-
Effect of chemotherapy on hippocampal volume and shape in older long-term breast cancer survivors Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-07 Ebenezer Daniel, Frank Deng, Sunita K. Patel, Mina S. Sedrak, Jonathan Young, Heeyoung Kim, Marianne Razavi, Can-Lan Sun, James C. Root, Tim A. Ahles, William Dale, Bihong T. Chen
PurposeThe objective of this study was to assess changes in hippocampal volume and shape in older long-term breast cancer survivors who were exposed to chemotherapy 5–15 years prior.MethodsThis study recruited female long-term breast cancer survivors aged 65 years or older with a history of chemotherapy (C+), age-matched breast cancer survivors who did not receive chemotherapy (C−), and healthy controls
-
Secure federated learning for Alzheimer's disease detection Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-07 Angela Mitrovska, Pooyan Safari, Kerstin Ritter, Behnam Shariati, Johannes Karl Fischer
Machine Learning (ML) is considered a promising tool to aid and accelerate diagnosis in various medical areas, including neuroimaging. However, its success is set back by the lack of large-scale public datasets. Indeed, medical institutions possess a large amount of data; however, open-sourcing is prevented by the legal requirements to protect the patient's privacy. Federated Learning (FL) is a viable
-
Assessing interstitial fluid dynamics in type 2 diabetes mellitus and prediabetes cases through diffusion tensor imaging analysis along the perivascular space Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-06 Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki
Background and purposeGlymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial
-
The mediating effect of 18F-FDG metabolism in right caudate between depressive symptoms and cognitive function in Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-06 Bojun Wang, Chunlei Cui, Yifan Chen, Zhigang Liang
PurposeThe objective of this study was to investigate the accumulation of 18F-fluorodeoxyglucose (18F-FDG) in the whole brain between Alzheimer’s disease (AD) with depressive (ADD) symptoms compared with AD without depressive (ADND) symptoms using positron emission tomography/magnetic resonance imaging (PET/MRI). Additionally, this study aimed to explore the associations among the accumulation of 18F-FDG
-
Anosognosia is associated with increased prevalence and faster development of neuropsychiatric symptoms in mild cognitive impairment Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-06 Sharon Wang, Kayden Mimmack, Federica Cacciamani, Michael Elnemais Fawzy, Catherine Munro, Jennifer Gatchel, Gad A. Marshall, Geoffroy Gagliardi, Patrizia Vannini
IntroductionBoth the loss of awareness for cognitive decline (a. k.a anosognosia) and neuropsychiatric symptoms (NPS) are common in patients with Alzheimer's disease (AD) dementia, even in prodromal stages, and may exacerbate functional impairment and negatively impact caregiver burden. Despite the high impact of these symptoms on patients and their caregivers, our knowledge of how they develop across
-
Non-invasive neuromodulation in reducing the risk of falls and fear of falling in community-dwelling older adults: systematic review Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-05 Guilherme Augusto Santos Bueno, Arthur Dutra do Bomfim, Lorrane Freitas Campos, Anabela Correia Martins, Raquel Brito Elmescany, Marina Morato Stival, Silvana Schwerz Funghetto, Ruth Losada de Menezes
IntroductionNeuromodulation is a non-invasive technique that allows for the modulation of cortical excitability and can produce changes in neuronal plasticity. Its application has recently been associated with the improvement of the motor pattern in older adults individuals with sequelae from neurological conditions.ObjectiveTo highlight the effects of non-invasive neuromodulation on the risk of falls
-
Altered resting-state functional connectivity and dynamic network properties in cognitive impairment: an independent component and dominant-coactivation pattern analyses study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-04 Maurizio Bergamino, Anna Burke, Marwan N. Sabbagh, Richard J. Caselli, Leslie C. Baxter, Ashley M. Stokes
Introduction Cognitive impairment (CI) due to Alzheimer’s disease (AD) encompasses a decline in cognitive abilities and can significantly impact an individual’s quality of life. Early detection and intervention are crucial in managing CI, both in the preclinical and prodromal stages of AD prior to dementia. Methods In this preliminary study, we investigated differences in resting-state functional connectivity
-
Light on Alzheimer's disease: from basic insights to preclinical studies Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-04 Jie Mi, Chao Liu, Honglei Chen, Yan Qian, Jingyi Zhu, Yachao Zhang, Yizhi Liang, Lidai Wang, Dean Ta
Alzheimer’s Disease (AD), referring to a gradual deterioration in cognitive function, including memory loss and impaired thinking skills, has emerged as a substantial worldwide challenge with profound social and economic implications. As the prevalence of AD continues to rise and the population ages, there is an imperative demand for innovative imaging techniques to help improve our understanding of
-
miR-3940-5p reduces amyloid β production via selectively targeting PSEN1 Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-04 Yanmei Qi, Xu Wang, Xihan Guo
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid beta (Aβ) in brain. Mounting evidence has revealed critical roles of microRNAs (miRNAs) in AD pathogenesis; however, the miRNAs directly targeting presenilin1 (PSEN1), which encodes the catalytic core subunit of γ-secretase that limits the production of Aβ from amyloid precursor protein
-
Impact of olfactory function on the trajectory of cognition, motor function, and quality of life in Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-04 Chia-Yen Lin, Yu-Shan Tsai, Ming-Hong Chang
BackgroundOlfactory dysfunction in Parkinson’s disease (PD) is associated with more severe phenotypes, but trajectories of cognitive function, disease severity, and subdomains of quality-of-life measurements in patients with distinct olfactory profiles remain underexplored.ObjectiveTo analyze the influence of olfaction on trajectories of clinical parameters in patients with PD.DesignRetrospective cohort
-
Short term effects of contralateral tendon vibration on motor unit discharge rate variability and force steadiness in people with Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-03-04 Changki Kim, Daryl J. Wile, Sarah N. Kraeutner, Kaylee Larocque, Jennifer Jakobi
BackgroundVibration of one limb affects motor performance of the contralateral limb, and this may have clinical implications for people with lateralized motor impairments through vibration-induced increase in cortical activation, descending neural drive, or spinal excitability.ObjectiveThe objective of this study was to evaluate the effects of acute biceps brachii tendon vibration on force steadiness
-
Improve the diagnosis of idiopathic normal pressure hydrocephalus by combining abnormal cortical thickness and ventricular morphometry Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-29 Yifeng Yang, Meijing Yan, Xiao Liu, Shihong Li, Guangwu Lin
BackgroundThe primary imaging markers for idiopathic Normal Pressure Hydrocephalus (iNPH) emphasize morphological measurements within the ventricular system, with no attention given to alterations in brain parenchyma. This study aimed to investigate the potential effectiveness of combining ventricular morphometry and cortical structural measurements as diagnostic biomarkers for iNPH.MethodsA total
-
Sensorineural hearing loss and cognitive impairment: three hypotheses Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-28 He Zhao, Yan Wang, Limei Cui, Hanjing Wang, Sha Liu, Tiantian Liang, Dawei Liu, Jingjing Qiu, Liang Chen, Yan Sun
Sensorineural hearing loss (SNHL) is a category of hearing loss that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness and auditory trauma, results in cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers to an abnormality in the brain’s higher intellectual processes related to learning, memory, thinking and judgment
-
Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis? Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-27 Long Yan, Hong Li, Yulin Qian, Junfeng Zhang, Shan Cong, Xuemin Zhang, Linna Wu, Yu Wang, Meng Wang, Tao Yu
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the vagus nerve distributed over the body surface. Studies suggest a correlation between the brain-gut-microbiota (BGM) axis and the pathogenesis of Alzheimer’s disease (AD). The BGM axis represents a complex bidirectional communication system, with the vagus nerve being a crucial component
-
Dual-task turn velocity – a novel digital biomarker for mild cognitive impairment and dementia Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-27 Jing Wang, Zheping Zhou, Shanshan Cheng, Li Zhou, Xiaoou Sun, Ziyang Song, Zhiwei Wu, Jinhua Lu, Yiren Qin, Yueju Wang
BackgroundDisorders associated with cognitive impairment impose a significant burden on both families and society. Previous studies have indicated that gait characteristics under dual-task as reliable markers of early cognitive impairment. Therefore, digital gait detection has great potential for future cognitive screening. However, research on digital biomarkers based on smart devices to identify
-
Modeling sporadic Alzheimer’s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-27 Kiruthika Ganesan, Peggy Rentsch, Alexander Langdon, Luke T. Milham, Bryce Vissel
IntroductionDeveloping effective treatment for Alzheimer’s disease (AD) remains a challenge. This can be partially attributed to the fact that the mouse models used in preclinical research largely replicate familial form of AD, while majority of human cases are sporadic; both forms differ widely in the onset and origin of pathology, therefore requiring specific/targeted treatments.MethodsIn this study
-
Cognitive performance in aged rats is associated with differences in distinctive neuronal populations in the ventral tegmental area and altered synaptic plasticity in the hippocampus Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-26 Claudia Sagheddu, Tamara Stojanovic, Shima Kouhnavardi, Artem Savchenko, Ahmed M. Hussein, Marco Pistis, Francisco J. Monje, Roberto Plasenzotti, Mohammed Aufy, Christian R. Studenik, Jana Lubec, Gert Lubec
IntroductionDeterioration of cognitive functions is commonly associated with aging, although there is wide variation in the onset and manifestation. Albeit heterogeneity in age-related cognitive decline has been studied at the cellular and molecular level, there is poor evidence for electrophysiological correlates. The aim of the current study was to address the electrophysiological basis of heterogeneity
-
Comparative analysis of multimodal biomarkers for amyloid-beta positivity detection in Alzheimer's disease cohorts Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-26 Mostafa Mehdipour Ghazi, Per Selnes, Santiago Timón-Reina, Sandra Tecelão, Silvia Ingala, Atle Bjørnerud, Bjørn-Eivind Kirsebom, Tormod Fladby, Mads Nielsen
IntroductionEfforts to develop cost-effective approaches for detecting amyloid pathology in Alzheimer's disease (AD) have gained significant momentum with a focus on biomarker classification. Recent research has explored non-invasive and readily accessible biomarkers, including magnetic resonance imaging (MRI) biomarkers and some AD risk factors.MethodsIn this comprehensive study, we leveraged a diverse
-
Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer’s disease in adult Alzheimer’s model AppNL-G-F mice Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-26 Suzuko Ochi, Kumiko Yamada, Takashi Saito, Takaomi C. Saido, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kubo
IntroductionAlzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (Aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. Many cohort studies indicate that tooth loss is a risk factor for AD. The detailed mechanisms underlying the association between AD and tooth
-
Mentha rotundifolia (L.) Huds. and Salvia officinalis L. hydrosols mitigate aging related comorbidities in rats Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-23 Khadija Boualam, Hind Ibork, Zakaria Lahboub, Mansour Sobeh, Khalid Taghzouti
IntroductionAging is often linked to oxidative stress, where the body experiences increased damage from free radicals. Plants are rich sources of antioxidants, playing a role in slowing down aging and supporting the proper functioning and longevity of cells. Our study focuses on exploring the impact of Mentha rotundifolia (MR) and Salvia officinalis (SO) hydrosols on aging-related comorbidities.MethodsThe
-
Association of immune cell traits with Parkinson’s disease: a Mendelian randomization study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-22 Zhiwei Song, Wangyu Li, Yupeng Han, Yiya Xu, Haiqi Ding, Yinzhou Wang
BackgroundImmunity and neuroinflammation play crucial roles in the pathogenesis of Parkinson’s disease (PD). Nonetheless, prior investigations into the correlation between immune inflammation and PD have produced varying results. Identifying specific immune cell phenotypes that are truly associated with PD is challenging, and the causal relationship between immune cells and PD remains elusive.MethodsThis
-
Trends in cognitive function before and after myocardial infarction: findings from the China Health and Retirement Longitudinal Study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-22 Jing Shang, Jianye Dong, Sijia Zhu, Qingmei Chen, Jianian Hua
ObjectivesIncident stroke was associated with cognitive dysfunction after stroke and even before stroke. However, cognitive trends prior to myocardial infarction (MI) and the timeline of cognitive decline in a few years following incident MI remain unclear, especially among the Chinese population. We aimed to evaluate whether MI was associated with cognitive change both before and after MI in China
-
A cross-sectional observational study for ethno-geographical disparities in sleep quality, brain morphometry and cognition (a SOLACE study) in Indians residing in India, and South Asians and Europeans residing in the UK – a study protocol Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-21 Rishabh Soni, Caroline Dale, Victoria Garfield, Nasreen Akhtar
IntroductionAs individuals age, their sleep patterns change, and sleep disturbances can increase the risk of dementia. Poor sleep quality can be a risk factor for mild cognitive impairment (MCI) and dementia. Epidemiological studies show a connection between sleep quality and cognitive changes, with brain imaging revealing grey matter volume reduction and amyloid beta accumulation in Alzheimer’s disease
-
Metabolic energy decline coupled dysregulation of catecholamine metabolism in physiologically highly active neurons: implications for selective neuronal death in Parkinson’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-21 Kandatege Wimalasena, Oluwatosin Adetuyi, Maya Eldani
Parkinson’s disease (PD) is an age-related irreversible neurodegenerative disease which is characterized as a progressively worsening involuntary movement disorder caused by the loss of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc). Two main pathophysiological features of PD are the accumulation of inclusion bodies in the affected neurons and the predominant loss of neuromelanin-containing
-
Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-21 Qian Xu, Meng Ji, Shicai Huang, Weifeng Guo
IntroductionEstradiol is a sex steroid hormone, which has been implicated in the pathogenesis of Alzheimer’s disease and cognitive impairment. This cross-sectional study aimed to examine the relationship between serum estradiol levels and cognitive performance in older American women.MethodsData were obtained from the National Health and Nutrition Examination Survey 2013–2014. A total of 731 women
-
Human stem cell transplantation models of Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-21 Nkechime Ifediora, Peter Canoll, Gunnar Hargus
Alzheimer’s disease (AD) is the most frequent form of dementia. It is characterized by pronounced neuronal degeneration with formation of neurofibrillary tangles and deposition of amyloid β throughout the central nervous system. Animal models have provided important insights into the pathogenesis of AD and they have shown that different brain cell types including neurons, astrocytes and microglia have
-
tRNS boosts visual perceptual learning in participants with bilateral macular degeneration Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-21 Giulio Contemori, Marcello Maniglia, Jade Guénot, Vincent Soler, Marta Cherubini, Benoit R. Cottereau, Yves Trotter
Perceptual learning (PL) has shown promise in enhancing residual visual functions in patients with age-related macular degeneration (MD), however it requires prolonged training and evidence of generalization to untrained visual functions is limited. Recent studies suggest that combining transcranial random noise stimulation (tRNS) with perceptual learning produces faster and larger visual improvements
-
Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-21 Lucas Ronat, Michael Rönnlund, Rolf Adolfsson, Alexandru Hanganu, Sara Pudas
IntroductionPersonality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and have both been identified as risks factors for development of aging-related neurocognitive decline and Alzheimer’s disease (AD). This study aimed to examine revised personality factors derived from the Temperament and Character Inventory, previously shown to be associated with psychiatric
-
Association between MTHFR C677T polymorphism and cognitive impairment in patients with cerebral small vessel disease: a cross-sectional study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-19 Qijin Wang, Cuihua Yuan, Zhixiong Zheng, Caihua Chen, Xiao Zhan, Xiaodan Lin
ObjectiveCerebral small vessel disease (CSVD) is the most common vascular cause of cognitive impairment. This study aimed to explore the association between MTHFR C677T polymorphism and cognitive impairment in CSVD patients.MethodsDemographic, medical, laboratory, cognitive evaluation, and MTHFR C677T polymorphism data were collected from CSVD patients admitted to our hospital between January 2019
-
Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-19 Roberto Collu, Zheng Yin, Elisa Giunti, Sarah Daley, Mei Chen, Peter Morin, Richard Killick, Stephen T. C. Wong, Weiming Xia
IntroductionThe goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil, a selective Ras homolog (Rho)-associated kinases (ROCK) inhibitor, in the P301S tau transgenic mouse model (Line PS19) of neurodegenerative tauopathy and Alzheimer's disease (AD).MethodsWe used LC-MS/MS, ELISA and bioinformatic approaches to investigate the effect of treatment
-
Emerging T cell immunoregulatory mechanisms in multiple sclerosis and Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-16 Daniel Hawiger
Multiple sclerosis (MS) and Alzheimer’s disease (AD) are neuroinflammatory and neurodegenerative diseases with considerable socioeconomic impacts but without definitive treatments. AD and MS have multifactorial pathogenesis resulting in complex cognitive and neurologic symptoms and growing evidence also indicates key functions of specific immune cells. Whereas relevant processes dependent on T cells
-
Investigating the shared genetic architecture between frailty and insomnia Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-15 Zhiwei Song, Wangyu Li, Yupeng Han, Yiya Xu, Yinzhou Wang
BackgroundThe epidemiological association between frailty and insomnia is well established, yet the presence of a common genetic etiology is still uncertain. Further exploration is needed to ascertain the causal relationship between frailty and insomnia.MethodsUtilizing data obtained from genome-wide association studies (GWAS) summaries, we utilized the linkage disequilibrium score regression (LDSC)
-
Diffusion kurtosis imaging of brain white matter alteration in patients with coronary artery disease based on the TBSS method Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-15 Tong Li, Rui Qin, Cuicui Li, Lin Li, Ximing Wang, Li Wang
ObjectThe aim of our study was to examine the alterations in microstructure in patients with coronary artery disease (CAD) and cognitive impairment (CI) using diffusion kurtosis imaging (DKI). Additionally, we aimed to investigate the potential correlation between DKI parameters and cognitive function.Materials and methodsA total of 28 CAD patients and 30 healthy controls (HC) were prospectively enrolled
-
High-frequency multimodal training with a focus on Tai Chi in people with Parkinson’s disease: a pilot study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-15 Ketevan Toloraia, Ute Gschwandtner, Peter Fuhr
Background and objectivesCognitive decline is an important and common complication in patients with Parkinson’s disease (PD) since it significantly reduces the quality of life. A breakthrough in treating and preventing cognitive decline in PD remains to be achieved. This study aimed to evaluate the effectiveness of high-frequency and intensive multimodal training in improving motor and cognitive function
-
IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-15 Lauren R. Miller, Marisa A. Bickel, Stefano Tarantini, Megan E. Runion, Zoe Matacchiera, Michaela L. Vance, Clara Hibbs, Hannah Vaden, Domonkos Nagykaldi, Teryn Martin, Elizabeth C. Bullen, Jessica Pinckard, Tamas Kiss, Eric W. Howard, Andriy Yabluchanskiy, Shannon M. Conley
IntroductionCerebrovascular pathologies contribute to cognitive decline during aging, leading to vascular cognitive impairment and dementia (VCID). Levels of circulating insulin-like growth factor 1 (IGF-1), a vasoprotective hormone, decrease during aging. Decreased circulating IGF-1 in animal models leads to the development of VCID-like symptoms, but the cellular mechanisms underlying IGF-1-deficiency
-
Protocol for a randomized, placebo-controlled, double-blind phase IIa study of the safety, tolerability, and symptomatic efficacy of the ROCK-inhibitor Fasudil in patients with Parkinson’s disease (ROCK-PD) Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-14 Andreas W. Wolff, Helen Bidner, Yvonne Remane, Janine Zimmer, Dag Aarsland, Olivier Rascol, Richard K. Wyse, Alexander Hapfelmeier, Paul Lingor
BackgroundThe Rho-kinase (ROCK) inhibitor Fasudil has shown symptomatic and disease-modifying effects in Parkinson’s disease (PD) models in vitro and in vivo. In Japan, Fasudil has been approved for the treatment of subarachnoid haemorrhage since 1995 and shows a favourable safety profile.Objectives/designTo investigate the safety, tolerability, and symptomatic efficacy of ROCK-inhibitor Fasudil in
-
Enriched oxygen improves age-related cognitive impairment through enhancing autophagy Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-14 Shengyuan Wang, Bengang Chen, Minghao Yuan, Shu Liu, Haixia Fan, Xu Yang, Qian Zou, Yinshuang Pu, Zhiyou Cai
Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechanisms and potential interventions being of paramount importance. This study aimed to investigate the effects of hyperbaric oxygen therapy (HBOT) on cognitive function and neuronal integrity in aged (22-month-old) C57BL/6 mice. Male mice were exposed to HBOT for 2 weeks, and spatial
-
Preliminary study on early diagnosis of Alzheimer’s disease in APP/PS1 transgenic mice using multimodal magnetic resonance imaging Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-14 Meng Xu, Jipeng Liu, Qingguo Liu, Yu Gong, Yinyin Li, Jing Zhang, Shufeng Shi, Yuanyuan Shi
Alzheimer’s disease (AD) has an insidious onset and lacks clear early diagnostic markers, and by the time overt dementia symptoms appear, the disease is already in the mid-to-late stages. The search for early diagnostic markers of AD may open a critical window for Alzheimer’s treatment and facilitate early intervention to slow the progression of AD. In this study, we aimed to explore the imaging markers
-
Associative Role of HLA-DRB1 as a Protective Factor for Susceptibility and Progression of Parkinson's Disease: A Chinese Cross-Sectional and Longitudinal Study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Raoli He, Yuqi Zeng, Chaodong Wang, Lina Chen, Guoen Cai, Ying Chen, Yingqing Wang, Qinyong Ye, Xiaochun Chen
Background: Previous genome-wide association studies investigating the relationship between the HLA-DRB1 and the risk of Parkinson's disease (PD) have shown limited racial diversity and have not explored clinical heterogeneity extensively.The study consisted of three parts: a case-control study, a cross-sectional study, and a longitudinal cohort study. The case-control study included 477 PD patients
-
Large-scale screening of clinical assessments to distinguish between states in the Integrated HD Progression Model (IHDPM) Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Zhaonan Sun, Jennifer Ware, Sanjoy Dey, Elif Eyigoz, Swati Sathe, Cristina Sampaio, Jianying Hu
BackgroundUnderstanding the sensitivity and utility of clinical assessments across different HD stages is important for study/trial endpoint selection and clinical assessment development. The Integrated HD Progression Model (IHDPM) characterizes the complex symptom progression of HD and separates the disease into nine ordered disease states.ObjectiveTo generate a temporal map of discriminatory clinical
-
Valid olfactory impairment tests can help identify mild cognitive impairment: an updated meta-analysis Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Chunyi Zhou, Chongming Yang, Yating Ai, Xueling Fang, Ailin Zhang, Yuncui Wang, Hui Hu
BackgroundOlfactory testing is emerging as a potentially effective screening method for identifying mild cognitive impairment in the elderly population.ObjectiveOlfactory impairment is comorbid with mild cognitive impairment (MCI) in older adults but is not well-documented in subdomains of either olfactory or subtypes of cognitive impairments in older adults. This meta-analysis was aimed at synthesizing
-
The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Jean-Baptiste Pérot, Emmanuel Brouillet, Julien Flament
Huntington’s disease is an inherited disorder characterized by psychiatric, cognitive, and motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal phase precedes the onset, lasting decades. Current biomarkers include clinical score and striatal atrophy using Magnetic Resonance Imaging (MRI). These markers lack sensitivity for subtle cellular changes during the prodromal
-
Relationship between physical activity and cerebral white matter hyperintensity volumes in older adults with depressive symptoms and mild memory impairment: a cross-sectional study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Shotaro Otsuka, Kiyoshi Kikuchi, Yasufumi Takeshita, Seiya Takada, Akira Tani, Harutoshi Sakakima, Ikuro Maruyama, Hyuma Makizako
IntroductionCerebral white matter hyperintensities (WMHs) are commonly found in the aging brain and have been implicated in the initiation and severity of many central nervous system diseases. Furthermore, an increased WMH volume indicates reduced brain health in older adults. This study investigated the association between WMH volume and physical activity in older adults with depressive symptoms (DS)
-
Risk factors and predictive markers of post-stroke cognitive decline–A mini review Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Xiaofan Guo, Cattien Phan, Sanad Batarseh, Miao Wei, Justin Dye
Stroke is one of the top causes of death and disability worldwide. Cognitive impairments are found in more than 70% of individuals who have survived a stroke. Cognitive decline is a major contributor to disability, dependency, and morbidity. The prevalence and severity of dementia vary depending on different characteristics of the stroke and other clinical risk factors. Here we discuss the effects
-
A case for seeking sex-specific treatments in Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-13 Marina A. Lynch
There is no satisfactory explanation for the sex-related differences in the incidence of many diseases and this is also true of Alzheimer’s disease (AD), where females have a higher lifetime risk of developing the disease and make up about two thirds of the AD patient population. The importance of understanding the cause(s) that account for this disproportionate distribution cannot be overestimated
-
Repetitive transcranial magnetic stimulation regulates effective connectivity patterns of brain networks in the spectrum of preclinical Alzheimer’s disease Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-12 Xuhong Liang, Chen Xue, Darui Zheng, Qianqian Yuan, Wenzhang Qi, Yiming Ruan, Shanshan Chen, Yu Song, Huimin Wu, Xiang Lu, Chaoyong Xiao, Jiu Chen
ObjectivesSubjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are considered as the spectrum of preclinical Alzheimer’s disease (AD), with abnormal brain network connectivity as the main neuroimaging feature. Repetitive transcranial magnetic stimulation (rTMS) has been proven to be an effective non-invasive technique for addressing neuropsychiatric disorders. This study
-
Higher remnant cholesterol is associated with an increased risk of amnestic mild cognitive impairment: a community-based cross-sectional study Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-12 Yating Ai, Chunyi Zhou, Ming Wang, Chongming Yang, Shi Zhou, Xinxiu Dong, Niansi Ye, Yucan Li, Ling Wang, Hairong Ren, Xiaolian Gao, Man Xu, Hui Hu, Yuncui Wang
Background and aimsAmnestic mild cognitive impairment (aMCI) is the most common subtype of MCI, which carries a significantly high risk of transitioning to Alzheimer’s disease. Recently, increasing attention has been given to remnant cholesterol (RC), a non-traditional and previously overlooked risk factor. The aim of this study was to explore the association between plasma RC levels and aMCI.MethodsData
-
Effectiveness of a multicomponent exercise intervention in community-dwelling older Chinese people with cognitive frailty: protocol for a mixed-methods research Front. Aging Neurosci. (IF 4.8) Pub Date : 2024-02-12 Hongting Ning, Fenghui Chen, Junxin Li, Yan Du, Xi Chen, Shuang Wu, Abigael Joseph, Yinyan Gao, Zeng Cao, Hui Feng
AimsTo evaluate the effectiveness of a multicomponent exercise intervention and to clarify the underlying mechanisms of the program in community-dwelling older adults with cognitive frailty. Additionally, the perception of participants in the program will be explored.DesignA mixed-methods design, including a randomized controlled trial and an exploratory qualitative study, was used.MethodsEach group