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Synthetic exendin-4 disrupts responding to reward predictive incentive cues in male rats Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-14 Ken T. Wakabayashi, Ajay N. Baindur, Malte Feja, Mauricio Suarez, Karie Chen, Kimberly Bernosky-Smith, Caroline E. Bass
Synthetic exendin-4 (EX4, exenatide), is a GLP-1 receptor agonist used clinically to treat glycemia in Type-2 diabetes mellitus. EX4 also promotes weight loss and alters food reward-seeking behaviors in part due to activation of GLP-1 receptors in the mesolimbic dopamine system. Evidence suggests that GLP-1 receptor activity can directly attenuate cue-induced reward seeking. Here, we tested the effects
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A meta-analysis of cognitive and functional outcomes in severe brain trauma cases Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-14 Zhang Shuanglong, Yuan Jiangyuan, Nie Meng, Wang Zheng, Zhang Yunshui, Sun Wei, Qiao Li, Jiang Rongcai
BackgroundSevere traumatic brain injuries (TBIs) are an important health issue worldwide, which are associated with harmful side effects. This meta-analysis investigates the cognitive and functional outcomes in severe brain trauma cases. It assesses the impact on memory, verbal and visual abilities, attention, learning, and the presence of depression. The study provides a comprehensive overview of
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Cognitive training of mice attenuates age-related decline in associative learning and behavioral flexibility Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-14 Dalia Attalla, Alexej Schatz, Katharina Stumpenhorst, York Winter
Identifying factors that influence age-related cognitive decline is crucial, given its severe personal and societal impacts. However, studying aging in human or animal models is challenging due to the significant variability in aging processes among individuals. Additionally, longitudinal and cross-sectional studies often produce differing results. In this context, home-cage-based behavioral analysis
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Tackling social anxiety with targeted brain stimulation: investigating the effects of transcranial static magnetic field stimulation on self-focused attention Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-13 Nozomi Tomita, Hiroki Katayama, Yuto Kurihara, Toru Takahashi, Sumiya Shibata, Tatsuya Mima, Rieko Osu, Hiroaki Kumano
Previous studies suggested that self-focused attention (SFA), implicated in social anxiety disorder (SAD), correlates with heightened activity in the right frontopolar area (rFPA), which is the right prefrontal cortex just behind the forehead. Transcranial static magnetic field stimulation (tSMS) is a non-invasive brain stimulation method capable of temporarily suppressing brain function beneath the
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Behavioral effects of visual stimuli in adult zebrafish using a novel eight-tank imaging system Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-11 Sayali V. Gore, Thaís Del Rosario Hernández, Robbert Creton
IntroductionAnimals respond to various environmental cues. Animal behavior is complex, and behavior analysis can greatly help to understand brain function. Most of the available behavioral imaging setups are expensive, provide limited options for customization, and allow for behavioral imaging of one animal at a time.MethodsThe current study takes advantage of adult zebrafish as a model organism to
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Remote memory in a Bayesian model of context fear conditioning (BaconREM) Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-07 Franklin B. Krasne, Michael S. Fanselow
Here, we propose a model of remote memory (BaconREM), which is an extension of a previously published Bayesian model of context fear learning (BACON) that accounts for many aspects of recently learned context fear. BaconREM simulates most known phenomenology of remote context fear as studied in rodents and makes new predictions. In particular, it predicts the well-known observation that fear that was
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The impact of stress on the behavior of C57BL/6 mice with liver injury: a comparative study Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-06 Mădălina Iuliana Mușat, Smaranda Ioana Mitran, Ion Udriștoiu, Carmen Valeria Albu, Bogdan Cătălin
IntroductionDepressive-like behavior has been shown to be associated with liver damage. This study aimed to evaluate the impact of three different models of depression on the behavior of mice with liver injury.MethodsDuring the 4 weeks of methionine/choline deficiency diet (MCD), adult C57BL/6 mice were randomly divided into four groups: MCD (no stress protocol, n = 6), chronic unpredictable mild stress
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The horizontal ladder test (HLT) protocol: a novel, optimized, and reliable means of assessing motor coordination in Sus scrofa domesticus Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-06 Xiaobo Liu, Ana G. Gutierrez, Arlette Vega, Joshua O. Willms, Jackson Driskill, Praneetha Panthagani, Jordan Sanchez, Monica Aguilera, Brittany Backus, Jeremy D. Bailoo, Susan E. Bergeson
Pigs can be an important model for preclinical biological research, including neurological diseases such as Alcohol Use Disorder. Such research often involves longitudinal assessment of changes in motor coordination as the disease or disorder progresses. Current motor coordination tests in pigs are derived from behavioral assessments in rodents and lack critical aspects of face and construct validity
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Prenatal and postnatal methamphetamine exposure alters prefrontal cortical gene expression and behavior in mice Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-05 Philip A. Adeniyi, Tolulope T. Adeyelu, Amita Shrestha, Chin-Chi Liu, Charles C. Lee
Methamphetamine is a highly abused psychostimulant that substantially impacts public health. Prenatal and postnatal methamphetamine exposure alters gene expression, brain development, and behavior in the offspring, although the underlying mechanisms are not fully defined. To assess these adverse outcomes in the offspring, we employed a mouse model of prenatal and postnatal methamphetamine exposure
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Improvement of symptoms in children with autism by TOMATIS training: a cross-sectional and longitudinal study Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-01 Yujia Fu, Mei Tian, Jiaxi Chen, Wenfeng Chen, Huang Li
Introduction Autism spectrum disorder (ASD) is a neurological condition that is marked by deficits in social interaction, difficulty expressing oneself, lack of enthusiasm, and stereotypical conduct. The TOMATIS training method is an effective music therapy for children with ASD for its individually developed programs to improve behavioral deficits. Methods The research employed both longitudinal and
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Sex differences in the context dependency of episodic memory Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-01 Aliza A. Le, Linda C. Palmer, Jasmine Chavez, Christine M. Gall, Gary Lynch
Context contributes to multiple aspects of human episodic memory including segmentation and retrieval. The present studies tested if, in adult male and female mice, context influences the encoding of odors encountered in a single unsupervised sampling session of the type used for the routine acquisition of episodic memories. The three paradigms used differed in complexity (single vs. multiple odor
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Chronic alcohol-induced long-lasting working memory deficits are associated with altered histone H3K9 dimethylation in the prefrontal cortex Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-03-01 Mael De Clerck, Martin Manguin, Nadia Henkous, Marion N. d’Almeida, Daniel Beracochea, Nicole Mons
IntroductionEpigenetic modifications have emerged as key contributors to the enduring behavioral, molecular and epigenetic neuroadaptations during withdrawal from chronic alcohol exposure. The present study investigated the long-term consequences of chronic alcohol exposure on spatial working memory (WM) and associated changes of transcriptionally repressive histone H3 lysine 9 dimethylation (H3K9me2)
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Appetitively motivated tasks in the IntelliCage reveal a higher motivational cost of spatial learning in male than female mice Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-29 Martina Nigri, Giulia Bramati, Adrian C. Steiner, David P. Wolfer
The IntelliCage (IC) permits the assessment of the behavior and learning abilities of mice in a social home cage context. To overcome water deprivation as an aversive driver of learning, we developed protocols in which spatial learning is motivated appetitively by the preference of mice for sweetened over plain water. While plain water is available at all times, only correct task responses give access
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Overwhelmed by beauty and faith: review on artistic and religious travelers’ syndromes Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-27 Damaris Cisneros-Ceh, Darina Esquivel-Heredia, Allan Medina-Vargas, Hugo Azcorra-Perez, Claudia Guadalupe Chi-Mendez, Alina D. Marin-Cardenas, Nina Mendez-Dominguez
Traveling with the intention of encountering art or seeking purification of the spirit involves retribution of intangible nature and therefore can be expected to be a positive experience; nevertheless, among susceptible travelers, there is also a possibility of experiencing pathological conditions. Although it is colloquially known that beauty lies in the eyes of the beholder, it is necessary to mention
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Dissimilarities of neural representations of extinction trials are associated with extinction learning performance and renewal level Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-26 Silke Lissek, Martin Tegenthoff
IntroductionRenewal of extinguished responses is associated with higher activity in specific extinction-relevant brain regions, i.e., hippocampus (HC), inferior frontal gyrus (IFG), and ventromedial PFC (vmPFC). HC is involved in processing of context information, while IFG and vmPFC use such context information for selecting and deciding among competing response options. However, it is as yet unknown
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Dorsal CA1 lesions of the hippocampus impact mating tactics in prairie voles by shifting non-monogamous males’ use of space to resemble monogamous males Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-26 Lindsay L. Sailer, Caitlyn J. Finton, Pooja P. Patel, Steven M. Bogdanowicz, Alexander G. Ophir
Alternative mating tactics within mating systems are characterized by discrete patterns of spatio-temporal overlap with same-and opposite-sex conspecifics and mating-relevant outcomes. Socially monogamous “residents” maintain relatively small home range sizes, have territories that almost exclusively overlap with their mating partners, and are more likely to produce offspring than non-bonded “wandering”
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Inhibition of corticosterone synthesis impairs cued water maze consolidation, but it does not affect the expression of BDNF, CK2 and SGK1 genes in dorsal striatum Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-26 Rogelio Pegueros-Maldonado, Santiago M. Pech-Pool, Jaisson J. Blancas, Roberto A. Prado-Alcalá, Carlos Arámburo, Maricela Luna, Gina L. Quirarte
Corticosterone (CORT) release during learning experiences is associated with strong memories and activity of the glucocorticoid receptor. It has been shown that lesions of the dorsal striatum (DS) of rats trained in the cued version of the Morris water maze impair memory, and that local injection of CORT improves its performance, suggesting that DS activity is involved in procedural memory which may
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The fear of spiders: perceptual features assessed in augmented reality Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-21 Sergio Frumento, Paolo Frumento, Marco Laurino, Danilo Menicucci, Angelo Gemignani
BackgroundPersons with specific phobias typically generalize the dangerousness of the phobic animal to all members of its species, possibly as a result of malfunctioning brain circuitry normally providing quick and dirty identification of evolutionary-relevant stimuli. An objective assessment of which perceptual features make an animal more or less scary to phobic and non-phobic people would help overcome
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Improving depression-like behaviors caused by diabetes is likely to offer a new perspective for the treatment of non-healing chronic wounds Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-19 Zhiqin Dong, Jijin Wu, Hanchen Cao, Jinqiang Lu
BackgroundThree phases are often involved in the intricate process of wound healing: inflammatory exudation, cell proliferation, and tissue remodeling. It is challenging for wounds to heal if conditions like ischemia, persistent pressure, infection, repetitive trauma, or systemic or localized illnesses arise during the healing process. Chronic wounds are persistent injuries that do not follow the normal
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Elevated fear states facilitate ventral hippocampal engagement of basolateral amygdala neuronal activity Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-14 Alexandra C. Ritger, Rachel K. Parker, Sydney Trask, Nicole C. Ferrara
Fear memory formation and retention rely on the activation of distributed neural circuits. The basolateral amygdala (BLA) and ventral hippocampus (VH) in particular are two regions that support contextual fear memory processes and share reciprocal connections. The VH → BLA pathway is critical for increases in fear after initial learning, in both fear renewal following extinction learning and during
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Exploring the dynamic interplay between learning and working memory within various cognitive contexts Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-14 Zakieh Hassanzadeh, Fariba Bahrami, Fariborz Dortaj
IntroductionThe intertwined relationship between reinforcement learning and working memory in the brain is a complex subject, widely studied across various domains in neuroscience. Research efforts have focused on identifying the specific brain areas responsible for these functions, understanding their contributions in accomplishing the related tasks, and exploring their adaptability under conditions
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The impact of out-of-home care on brain development: a brief review of the neuroscientific evidence informing our understanding of children's attachment outcomes Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-13 Paula S. Oliveira
Researchers interested in the effects of early experiences of caregiving adversity have employed neuroscientific methods to illuminate whether and how such environmental input impacts on brain development, and whether and how such impacts underpin poor socioemotional outcomes in this population. Evidence is compelling in documenting negative effects on the individual's neurodevelopment following exposure
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Behavioral and neurophysiological effects of buspirone in healthy and depression-like state juvenile salmon Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-12 Sheyda Shapouri, Aziz Sharifi, Ole Folkedal, Thomas W. K. Fraser, Marco A. Vindas
A proportion of farmed salmon in seawater show a behaviorally inhibited, growth stunted profile known as a depression-like state (DLS). These DLS fish are characterized by chronically elevated serotonergic signaling and blood plasma cortisol levels and the inability to react further to acute stress, which is suggestive of chronic stress. In this study, we characterize the neuroendocrine profile of
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The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-07 Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer
We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5). Primary screening in zebrafish (Danio rerio) revealed a stimulatory effect of two peptides, LCGM-10 and LCGM-15. Target validation studies using calcium ion flux imaging and a luciferase reporter
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Chemogenetic inhibition of the ventral hippocampus but not its direct projection to the prelimbic cortex attenuates context-specific operant responding Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-07 Callum M. P. Thomas, Mark E. Bouton, John T. Green
Previous work has demonstrated the importance of the prelimbic cortex (PL) in contextual control of operant behavior. However, the associated neural circuitry responsible for providing contextual information to the PL is not well understood. In Pavlovian fear conditioning the ventral hippocampus (vH) and its projection to the PL have been shown to be important in supporting the effects of context on
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Influence of short-term hypoxic exposure on spatial learning and memory function and brain-derived neurotrophic factor in rats—A practical implication to human's lost way Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-06 Masataka Kiuchi, Tadashi Uno, Tatsuya Hasegawa, Katsuhiro Koyama, Masahiro Horiuchi
The present study aimed to investigate the effects of a short period of normobaric hypoxic exposure on spatial learning and memory, and brain-derived neurotrophic factor (BDNF) levels in the rat hippocampus. Hypoxic conditions were set at 12.5% O2. We compared all variables between normoxic trials (Norm), after 24 h (Hypo-24 h), and after 72 h of hypoxic exposure (Hypo-72 h). Spatial learning and memory
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Neurexin dysfunction in neurodevelopmental and neuropsychiatric disorders: a PRIMSA-based systematic review through iPSC and animal models Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-06 Dan Shan, Yuming Song, Yanyi Zhang, Cheong Wong Ho, Wenxin Xia, Zhi Li, Fenfen Ge, Qifeng Ou, Zijie Dai, Zhihao Dai
BackgroundNeurexins, essential synaptic proteins, are linked to neurodevelopmental and neuropsychiatric disorders like autism spectrum disorder (ASD) and schizophrenia.ObjectiveThrough this systematic review, we aimed to shed light on the relationship between neurexin dysfunction and its implications in neurodevelopmental and neuropsychiatric manifestations. Both animal and human-induced pluripotent
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Brain reward function in people who use cannabis: a systematic review Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-06 Emillie Beyer, Govinda Poudel, Stephanie Antonopoulos, Hannah Thomson, Valentina Lorenzetti
RationaleCannabis is one of the most widely used psychoactive substances globally. Cannabis use can be associated with alterations of reward processing, including affective flattening, apathy, anhedonia, and lower sensitivity to natural rewards in conjunction with higher sensitivity to cannabis-related rewards. Such alterations have been posited to be driven by changes in underlying brain reward pathways
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Neural circuits for the adaptive regulation of fear and extinction memory Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-02-02 Samantha L. Plas, Tuğçe Tuna, Hugo Bayer, Vitor A. L. Juliano, Samantha O. Sweck, Angel D. Arellano Perez, James E. Hassell, Stephen Maren
The regulation of fear memories is critical for adaptive behaviors and dysregulation of these processes is implicated in trauma- and stress-related disorders. Treatments for these disorders include pharmacological interventions as well as exposure-based therapies, which rely upon extinction learning. Considerable attention has been directed toward elucidating the neural mechanisms underlying fear and
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Postoperative cognitive dysfunction—current research progress Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-30 Qi Zhao, Hui Wan, Hui Pan, Yiquan Xu
Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD
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Effects of reproductive experience on cost-benefit decision making in female rats Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-29 Mojdeh Faraji, Omar A. Viera-Resto, Barry Setlow, Jennifer L. Bizon
Many individuals undergo mating and/or other aspects of reproductive experience at some point in their lives, and pregnancy and childbirth in particular are associated with alterations in the prevalence of several psychiatric disorders. Research in rodents shows that maternal experience affects spatial learning and other aspects of hippocampal function. In contrast, there has been little work in animal
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A comparison of machine learning methods for quantifying self-grooming behavior in mice Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-29 Kassi Correia, Raegan Walker, Christopher Pittenger, Christopher Fields
BackgroundAs machine learning technology continues to advance and the need for standardized behavioral quantification grows, commercial and open-source automated behavioral analysis tools are gaining prominence in behavioral neuroscience. We present a comparative analysis of three behavioral analysis pipelines—DeepLabCut (DLC) and Simple Behavioral Analysis (SimBA), HomeCageScan (HCS), and manual scoring—in
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Dual role of α7 nicotinic acetylcholine receptors in the retrosplenial cortex for aversive memory acquisition and retrieval Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-26 Verónica Pastor, Cynthia Katche
In the retrosplenial cortex (RSC), the role of cholinergic modulation via α7 nicotinic receptors and their involvement in memory is unknown. In recent years, the RSC has been shown to deteriorate in the early stages of Alzheimer’s disease (AD). Likewise, the cholinergic system has been postulated as one of those responsible for cognitive impairment in patients with AD. Great interest has arisen in
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Assessing cognitive biases induced by acute formalin or hotplate treatment: an animal study using affective bias test Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-25 Yu-Han Zhang, Jie-Xuan Lin, Ning Wang, Jin-Yan Wang, Fei Luo
Pain, a universal and burdensome condition, influences numerous individuals worldwide. It encompasses sensory, emotional, and cognitive facets, with recent research placing a heightened emphasis on comprehending pain’s impact on emotion and cognition. Cognitive bias, which encompasses attentional bias, interpretation bias, and memory bias, signifies the presence of cognitive distortions influenced
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Age-related positivity effect in emotional memory consolidation from middle age to late adulthood Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-24 Xinran Niu, Mia F. Utayde, Kristin E. G. Sanders, Dan Denis, Elizabeth A. Kensinger, Jessica D. Payne
BackgroundWhile younger adults are more likely to attend to, process, and remember negative relative to positive information, healthy older adults show the opposite pattern. The current study evaluates when, exactly, this positivity shift begins, and how it influences memory performance for positive, negative, and neutral information.MethodsA total of 274 healthy early middle-aged (35–47), late middle-aged
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Neurophysiology of male sexual arousal—Behavioral perspective Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-24 Wiktor Bogacki-Rychlik, Katarzyna Gawęda, Michal Bialy
In the presented review, we analyzed the physiology of male sexual arousal and its relation to the motivational aspects of this behavior. We highlighted the distinction between these processes based on observable physiological and behavioral parameters. Thus, we proposed the experimentally applicable differentiation between sexual arousal (SA) and sexual motivation (SM). We propose to define sexual
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Early ultrasonic vocalization deficits and related thyroarytenoid muscle pathology in the transgenic TgF344-AD rat model of Alzheimer’s disease Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-23 Denis Michael Rudisch, Maryann N. Krasko, David G. S. Barnett, Kimberly D. Mueller, John A. Russell, Nadine P. Connor, Michelle R. Ciucci
BackgroundAlzheimer’s disease (AD) is a progressive neurologic disease and the most common cause of dementia. Classic pathology in AD is characterized by inflammation, abnormal presence of tau protein, and aggregation of β-amyloid that disrupt normal neuronal function and lead to cell death. Deficits in communication also occur during disease progression and significantly reduce health, well-being
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Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-17 Erisa Met Hoxha, Payton K. Robinson, Kaitlyn M. Greer, Sydney Trask
IntroductionIn a variety of behavioral procedures animals will show selective fear responding in shock-associated contexts, but not in other contexts. However, several factors can lead to generalized fear behavior, where responding is no longer constrained to the conditioning context and will transfer to novel contexts.MethodsHere, we assessed memory generalization using an inhibitory avoidance paradigm
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Exploring the role of inflammation in major depressive disorder: beyond the monoamine hypothesis Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-17 Irene Pastis, Melody G. Santos, Akshita Paruchuri
Major depressive disorder affects approximately 8.4% of the United States population. The World Health Organization estimates that 280 million adults worldwide are suffering from depression. They have estimated that by 2030 it will be the second most serious condition. Current treatment relies on the monoamine hypothesis, however, one-third of patients with MDD do not respond to monoamine-based antidepressants
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Estradiol reduction through aromatase inhibition impairs cocaine seeking in male rats Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-16 John K. Alvarado-Torres, Roberto Morales-Silva, Alexia Sanabria Ponce de Leon, Genesis Rodriguez-Torres, Joshua Perez-Torres, Yobet Perez-Perez, Devin Mueller, Marian T. Sepulveda-Orengo
IntroductionClinical and preclinical research on cocaine use disorder (CUD) has shown that sex differences in drug seeking are influenced by hormonal fluctuations. Estradiol (E2), a sex steroid hormone, has been linked to female drug effects, vulnerability to use/abuse, and psychosocial factors. Preclinical studies show that estradiol in females facilitates the extinction of cocaine-seeking behavior
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Does acupuncture treatment modulate inflammatory cytokines in rodent models of depression? A systematic review and meta-analysis Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-15 Ziyi Guo, Zhuoyu Ren, Jianping Yao, Yamin Li, Zhiying Che, Zhiyang Yu, Peigang Fang, Xiao Lu, Min Chen
BackgroundDespite the increasing global prevalence of depression, existing treatment methods have limitations. Acupuncture has been recognized for its potential to alleviate various diseases by regulating inflammatory cytokines. However, a comprehensive systematic analysis of the effects of acupuncture on depression through inflammatory cytokines is currently lacking. This review aims to evaluate the
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Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-15 Kolter Grigsby, Zaynah Usmani, Justin Anderson, Angela Ozburn
Maintaining healthy and consistent levels of physical activity (PA) is a clinically proven and low-cost means of reducing the onset of several chronic diseases and may provide an excellent strategy for managing mental health and related outcomes. Wheel-running (WR) is a well-characterized rodent model of voluntary PA; however, its use in biomedical research is limited by economical and methodical constraints
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Oral administration of resveratrol reduces oxidative stress generated in the hippocampus of Wistar rats in response to consumption of ethanol Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-11 Addí Rhode Navarro-Cruz, Daniel Juárez-Serrano, Ivan Cesar-Arteaga, Ashuin Kammar-García, Jorge Alberto Guevara-Díaz, Obdulia Vera-López, Martin Lazcano-Hernández, Ivonne Pérez-Xochipa, Orietta Segura-Badilla
IntroductionChronic ethanol intake has been found to favor hippocampal deterioration and alter neuronal morphological maturation; resveratrol has been suggested as an antioxidant that may counteract these effects. The objective of this study was to analyze the effect of resveratrol on oxidative stress markers, endogenous antioxidant system in the hippocampus, and the behavior of male Wistar rats administered
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Hippocampal neurogenesis facilitates cognitive flexibility in a fear discrimination task Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-11 Alonso Martínez-Canabal, Grecia López-Oropeza, Francisco Sotres-Bayón
Hippocampal neurogenesis, the continuous creation of new neurons in the adult brain, influences memory, regulates the expression of defensive responses to threat (fear), and cognitive processes like pattern separation and behavioral flexibility. One hypothesis proposes that neurogenesis promotes cognitive flexibility by degrading established memories and promoting relearning. Yet, empirical evidence
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Enduring sex-dependent implications of pubertal stress on the gut-brain axis and mental health Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-11 Michaela Dworsky-Fried, Jessica A. Tchida, Rebecca Krnel, Nafissa Ismail
The gut-brain axis (GBA) is a network responsible for the bidirectional communication between the central nervous system and the gastrointestinal tract. This multifaceted system is comprised of a complex microbiota, which may be altered by both intrinsic and extrinsic factors. During critical periods of development, these intrinsic and extrinsic factors can cause long-lasting sex-dependent changes
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Dietary supplementation of 3′-sialyllactose or 6′-sialyllactose elicits minimal influence on cognitive and brain development in growing pigs Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-10 Rebecca K. Golden, Loretta T. Sutkus, Sharon M. Donovan, Ryan N. Dilger
Sialylated human milk oligosaccharides (HMO), such as 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL), are abundant throughout lactation and at much higher concentrations than are present in bovine milk or infant formulas. Previous studies have suggested that sialylated HMO may have neurocognitive benefits in early life. Recent research has focused on infant formula supplementation with key nutrients
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Open field test for the assessment of anxiety-like behavior in Gnathonemus petersii fish Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-10 Petra Horka, Veronika Langova, Jan Hubeny, Karel Vales, Ivana Chrtkova, Jiri Horacek
The open field test (OFT) is a basic and most widely used test for investigation in animal studies of the neurobiological basis of anxiety and screening for novel drug targets. Here, we present the results of an OFT for weakly electric fish Gnathonemus petersii. This study aimed to describe the behavioral response of G. petersii exposed to an OFT, simultaneously with an evaluation of electrical organ
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A reinforcement learning model with choice traces for a progressive ratio schedule Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-10 Keiko Ihara, Yu Shikano, Sae Kato, Sho Yagishita, Kenji F. Tanaka, Norio Takata
The progressive ratio (PR) lever-press task serves as a benchmark for assessing goal-oriented motivation. However, a well-recognized limitation of the PR task is that only a single data point, known as the breakpoint, is obtained from an entire session as a barometer of motivation. Because the breakpoint is defined as the final ratio of responses achieved in a PR session, variations in choice behavior
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The effect of experiences of fairness on honest behavior: a behavioral and neural study Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-08 Chen Zhang, Ming Yin, Jixia Wu
Prior studies have investigated the relationship between fairness and honesty. However, the differences in the focus of these studies have rendered cross-comparisons between them challenging and of limited value. Thus, this study explored how fairness impacts honest decision-making, focusing specifically on the effect of individuals’ experiences of fairness on their honest behavior. Experiment 1 explored
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The neural correlates of perceived social support and its relationship to psychological well-being Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-08 Huanhua Lu, Yiying Song, Xu Wang, Jia Liu
IntroductionPerceived social support is considered to play a significant role in promoting individuals’ health and well-being, and yet the neural correlates of perceived social support were not fully understood. An exploration of the neural correlates of individual differences in the SPS can help us to gain more comprehensive understanding about the neural correlates of perceived social support. What’s
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Age-related alterations in the behavioral response to a novel environment in the African turquoise killifish (Nothobranchius furzeri) Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-08 Valerie Mariën, Ilayda Piskin, Caroline Zandecki, Jolien Van houcke, Lutgarde Arckens
The African turquoise killifish (Nothobranchius furzeri) has emerged as a popular model organism for neuroscience research in the last decade. One of the reasons for its popularity is its short lifespan for a vertebrate organism. However, little research has been carried out using killifish in behavioral tests, especially looking at changes in their behavior upon aging. Therefore, we used the open
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The effect of CNQX on self-administration: present in nicotine, absent in methamphetamine model Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-05 Maria Hrickova, Petra Amchova, Jana Ruda-Kucerova
ObjectiveAddiction is a chronic disease with limited pharmacological options for intervention. Focusing on reducing glutamate levels in the brain seems to be a promising strategy in addiction treatment research. Our research aimed to evaluate the effects of CNQX, an antagonist that targets AMPA and kainate glutamatergic receptors while also exhibiting affinity for the NMDA receptor, especially by modulating
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Entrance-sealing behavior in the home cage: a defensive response to potential threats linked to the serotonergic system and manifestation of repetitive/stereotypic behavior in mice Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-05 Noriko Horii-Hayashi, Kazuya Masuda, Taika Kato, Kenta Kobayashi, Ayumu Inutsuka, Miyu F. Nambu, Kazumasa Z. Tanaka, Koichi Inoue, Mayumi Nishi
The security of animal habitats, such as burrows and nests, is vital for their survival and essential activities, including eating, mating, and raising offspring. Animals instinctively exhibit defensive behaviors to protect themselves from imminent and potential threats. In 1963, researchers reported wild rats sealing the entrances to their burrows from the inside using materials such as mud, sand
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Exploring age-related changes in saccades during cognitive tasks in healthy adults Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-05 Hee Won Yang, Jin Yeong Choe, Soo Rim Noh, Jeong Lan Kim, Ji Won Han, Ki Woong Kim
IntroductionAlthough eye movements such as saccades are related to internal cognitive processes and are independent of visual processing, few studies have investigated whether non-visual cognitive tasks simultaneously affect horizontal and vertical saccades in younger and older adults.MethodsWe recruited 28 younger adults aged 20–29 years and 26 older adults aged >60 years through advertisements in
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Cocaine reward and reinstatement in adolescent versus adult rodents Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-05 Amy A. Arguello, Christian T. Valade, Luciano S. Voutour, Christopher A. Reeves
Adolescence is a critical juncture when initiation of drug use intersects with profound developmental changes in the brain. Adolescent drug use increases the risk to develop substance use disorders (SUDs) later in life, but the mechanisms that confer this vulnerability are not understood. SUDs are defined by cycles of use, abstinence, and relapse. Intense craving during drug-free periods is often triggered
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Prenatal paternal anxiety symptoms predict child DHEA levels and internalizing symptoms during adrenarche Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-04 Sherri Lee Jones, Victoria De Braga, Christina Caccese, Jimin Lew, Guillaume Elgbeili, Natalie Castellanos-Ryan, Sophie Parent, Gina Muckle, Catherine M. Herba, William D. Fraser, Simon Ducharme, Julia Barnwell, Jacquetta Trasler, Jean R. Séguin, Tuong-Vi Nguyen, Tina C. Montreuil
IntroductionThis study examined (1) whether measures of paternal anxious and depressive symptoms collected prenatally and during a follow-up assessment when the child was in middle childhood, predict child neuroendocrine outcomes, and (2) whether neuroendocrine outcomes are intermediate factors between paternal mental health and child cognitive/behavioral outcomes. Middle childhood coincides with increased
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IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system Front. Behav. Neurosci. (IF 3.0) Pub Date : 2024-01-03 Hans-Peter Lipp, Sven Krackow, Emir Turkes, Seico Benner, Toshihiro Endo, Holger Russig
IntelliCage for mice is a rodent home-cage equipped with four corner structures harboring symmetrical double panels for operant conditioning at each of the two sides, either by reward (access to water) or by aversion (non-painful stimuli: air-puffs, LED lights). Corner visits, nose-pokes and actual licks at bottle-nipples are recorded individually using subcutaneously implanted transponders for RFID
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In depth behavioral phenotyping unravels complex motor disturbances in Cstb−/− mouse, a model for progressive myoclonus epilepsy type 1 Front. Behav. Neurosci. (IF 3.0) Pub Date : 2023-12-21 Eveliina Pollari, Saara Tegelberg, Harry Björklund, Reetta Kälviäinen, Anna-Elina Lehesjoki, Antti Haapalinna
Progressive myoclonus epilepsy type 1 (EPM1) is an autosomal recessively inherited childhood–adolescence onset neurodegenerative disease caused by mutations in the cystatin B (CSTB gene). The key clinical manifestation in EPM1 is progressive, stimulus-sensitive, in particular action-induced myoclonus. The cystatin B-deficient mouse model, Cstb−/−, has been described to present with myoclonic seizures
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Ethorobotic rats for rodent behavioral research: design considerations Front. Behav. Neurosci. (IF 3.0) Pub Date : 2023-12-21 Robert Siddall
The development of robots as tools for biological research, sometimes termed “biorobotics”, has grown rapidly in recent years, fueled by the proliferation of miniaturized computation and advanced manufacturing techniques. Much of this work is focused on the use of robots as biomechanical models for natural systems. But, increasingly, biomimetic robots are being employed to interact directly with animals
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Identification of neural circuits controlling male sexual behavior and sexual motivation by manganese-enhanced magnetic resonance imaging Front. Behav. Neurosci. (IF 3.0) Pub Date : 2023-12-21 Lorena Gaytán-Tocavén, Alejandro Aguilar-Moreno, Juan Ortiz, Sarael Alcauter, Edwards Antonio-Cabrera, Raúl G. Paredes
IntroductionDifferent techniques have been used to identify the brain regions that control sexual motivation and sexual behavior. However, the influence of sexual experience on the activation of these brain regions in the same subject is unknown. Using manganese-enhanced magnetic resonance imaging (MEMRI), we analyzed the activation of brain regions in the sexual incentive motivation (SIM) and the