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Effect of “needle sensation” and the real-time changes in autonomic nervous system activity during acupuncture analgesia Front. Neurosci. (IF 4.3) Pub Date : 2024-03-15 Zehua Liu, Jinglei Huang, Dingshang Yan, Sha Liang, Shatong Zhao, Mengzhen Zhang, Zhongwen Li, Chuliang Jiang, Xiang Yin, Yingjun Zhang, Tianshu Hou, Min Feng
IntroductionAcupuncture analgesia (AA) is widely used in clinical practice. The autonomic nervous system (ANS) may be an important pathway for acupuncture signal transduction. However, real-time changes in autonomic function during AA and the effect of “needle sensation” remain unclear.MethodsWe established a human pain model in healthy adults and randomly assigned 128 participants to the model, sham
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Improving wheelchair user sitting posture to alleviate lumbar fatigue: a study utilizing sEMG and pressure sensors Front. Neurosci. (IF 4.3) Pub Date : 2024-03-15 Zizheng Huang, Jianwei Cui, Yuanbo Wang, Siji Yu
BackgroundThe wheelchair is a widely used rehabilitation device, which is indispensable for people with limited mobility. In the process of using a wheelchair, they often face the situation of sitting for a long time, which is easy to cause fatigue of the waist muscles of the user. Therefore, this paper hopes to provide more scientific guidance and suggestions for the daily use of wheelchairs by studying
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Contralateral acupuncture for migraine without aura: a randomized trial protocol with multimodal MRI Front. Neurosci. (IF 4.3) Pub Date : 2024-03-15 Ziwen Chen, Qifu Li, Yi Lu, Gaoyangzi Huang, Ya Huang, Xianmei Pei, Yi Gong, Bingkui Zhang, Xin Tang, Zili Liu, Taipin Guo, Fanrong Liang
IntroductionMigraine is a common clinical disorder, ranks as the second most disabling disease worldwide, and often manifests with unilateral onset. Contralateral acupuncture (CAT), as a classical acupuncture method, has been proven to be effective in the treatment of migraine without aura (MWoA). However, its neural mechanisms have not been investigated using multimodal magnetic resonance imaging
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Theta-frequency medial septal nucleus deep brain stimulation increases neurovascular activity in MK-801-treated mice Front. Neurosci. (IF 4.3) Pub Date : 2024-03-15 Lindsey M. Crown, Kofi A. Agyeman, Wooseong Choi, Nancy Zepeda, Ege Iseri, Pooyan Pahlavan, Steven J. Siegel, Charles Liu, Vasileios Christopoulos, Darrin J. Lee
IntroductionDeep brain stimulation (DBS) has shown remarkable success treating neurological and psychiatric disorders including Parkinson’s disease, essential tremor, dystonia, epilepsy, and obsessive-compulsive disorder. DBS is now being explored to improve cognitive and functional outcomes in other psychiatric conditions, such as those characterized by reduced N-methyl-D-aspartate (NMDA) function
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Objective preclinical measures for bone conduction implants Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Irina Wils, Alexander Geerardyn, Tristan Putzeys, Guy Fierens, Kathleen Denis, Nicolas Verhaert
The study evaluates the accuracy of predicting intracochlear pressure during bone conduction stimulation using promontory velocity and ear canal pressure, as less invasive alternatives to intracochlear pressure. Stimulating with a percutaneous bone conduction device implanted in six human cadaveric ears, measurements were taken across various intensities, frequencies, and stimulation positions. Results
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Combining detrended cross-correlation analysis with Riemannian geometry-based classification for improved brain-computer interface performance Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Frigyes Samuel Racz, Satyam Kumar, Zalan Kaposzta, Hussein Alawieh, Deland Hu Liu, Ruofan Liu, Akos Czoch, Peter Mukli, José del R. Millán
Riemannian geometry-based classification (RGBC) gained popularity in the field of brain-computer interfaces (BCIs) lately, due to its ability to deal with non-stationarities arising in electroencephalography (EEG) data. Domain adaptation, however, is most often performed on sample covariance matrices (SCMs) obtained from EEG data, and thus might not fully account for components affecting covariance
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Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Maria Letizia Potenza, Stefan Blankvoort, Miguel M. Carvalho, Joachim S. Grimstvedt, Valentina Di Maria, Kristian Moan, Rajeevkumar Raveendran Nair, Marcus S. Flatset, Qiangwei Zhang, Laurent F. Thomas, Francois P. Pauzin, Rodolfo Da Silva Mazzarini Baldinotti, Giulia Quattrocolo, Clive R. Bramham, Pål Sætrom, Menno P. Witter, Clifford G. Kentros
Accurate investigations of neural circuitry require specific genetic access to individual circuit elements, i.e., the myriad neuronal cell-types in the brain. However, native promoters cannot achieve this because while most genes are expressed in the brain, few are expressed in a single neuronal cell-type. We recently used enhancers, the subcomponents of the transcriptional apparatus which tell promoters
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The neurophysiological effect of mild hypothermia in gyrencephalic brains submitted to ischemic stroke and spreading depolarizations Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Roberto Díaz-Peregrino, Modar Kentar, Carlos Trenado, Renán Sánchez-Porras, Pablo Albiña-Palmarola, Francisco L. Ramírez-Cuapio, Daniel San-Juan, Andreas Unterberg, Johannes Woitzik, Edgar Santos
ObjectiveCharacterize the neurophysiological effects of mild hypothermia on stroke and spreading depolarizations (SDs) in gyrencephalic brains.MethodsLeft middle cerebral arteries (MCAs) of six hypothermic and six normothermic pigs were permanently occluded (MCAo). Hypothermia began 1 h after MCAo and continued throughout the experiment. ECoG signals from both frontoparietal cortices were recorded
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Precise and low-power closed-loop neuromodulation through algorithm-integrated circuit co-design Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Jie Yang, Shiqi Zhao, Junzhe Wang, Siyu Lin, Qiming Hou, Mohamad Sawan
Implantable neuromodulation devices have significantly advanced treatments for neurological disorders such as Parkinson’s disease, epilepsy, and depression. Traditional open-loop devices like deep brain stimulation (DBS) and spinal cord stimulators (SCS) often lead to overstimulation and lack adaptive precision, raising safety and side-effect concerns. Next-generation closed-loop systems offer real-time
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Utilization of peripheral nerve feedback at a preconscious level Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Nabeel Hasan Chowdhury, Dustin James Tyler
IntroductionSensorimotor integration is important, if not required, when using our hands. The integration of the tactile and motor systems is disrupted in individuals with upper limb amputations because their connection to their fingertips is lost. Direct cortical stimulation allows for modality and location matched perceptions; however, studies show that the time to process and act upon direct cortical
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Research on the electromyography-based pattern recognition for inter-limb coordination in human crawling motion Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Chengxiang Li, Xiang Chen, Xu Zhang, De Wu
Aiming to provide a feasible crawling motion analysis method for clinical application, this study introduced electromyography (EMG)-based motion intention recognition technology into the pattern recognition of inter-limb coordination during human crawling for the first time. Eight inter-limb coordination modes (ILCMs) were defined. Ten adult participants were recruited, and each participant performed
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Therapeutic value of homeoprotein signaling pathways Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Ariel A. Di Nardo, Alain Prochiantz
Cell signaling based on homeoprotein transfer is a pathway with developmental and physiological functions. For a few transcription factors of this family, primarily ENGRAILED1, ENGRAILED2 and OTX2, their physiological functions have led to therapeutic strategies in animal models of human diseases, including Parkinson’s disease, amyotrophic lateral sclerosis, amblyopia and anxiety-related disorders
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Classification of high-grade glioblastoma and single brain metastases using a new SCAT-inception model trained with MRI images Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Cheng Lv, Xu-Jun Shu, Hui Chang, Jun Qiu, Shuo Peng, Keping Yu, Sheng-Bo Chen, Hong Rao
Background and objectivesGlioblastoma (GBM) and brain metastasis (MET) are the two most common intracranial tumors. However, the different pathogenesis of the two tumors leads to completely different treatment options. In terms of magnetic resonance imaging (MRI), GBM and MET are extremely similar, which makes differentiation by imaging extremely challenging. Therefore, this study explores an improved
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Emotion recognition based on microstate analysis from temporal and spatial patterns of electroencephalogram Front. Neurosci. (IF 4.3) Pub Date : 2024-03-14 Zhen Wei, Hongwei Li, Lin Ma, Haifeng Li
IntroductionRecently, the microstate analysis method has been widely used to investigate the temporal and spatial dynamics of electroencephalogram (EEG) signals. However, most studies have focused on EEG at resting state, and few use microstate analysis to study emotional EEG. This paper aims to investigate the temporal and spatial patterns of EEG in emotional states, and the specific neurophysiological
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Advancing genetic testing for neurological disorders in Tanzania: importance, challenges, and strategies for implementation Front. Neurosci. (IF 4.3) Pub Date : 2024-03-13 Mohamed Zahir Alimohamed, Angela Augustine Siima, Mohamed Manji
This manuscript discusses the critical need for advancing genetic testing capabilities for neurological disorders (NDs) in Tanzania, emphasizing the importance, challenges, and strategies for implementation. Neurological disorders, often caused by a complex interplay of genetic and environmental factors, disproportionately affect low and middle-income countries like Tanzania. Patients with neurogenetic
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Long-term effects of mobile exoneuromusculoskeleton (ENMS)-assisted self-help telerehabilitation after stroke Front. Neurosci. (IF 4.3) Pub Date : 2024-03-13 Wanyi Qing, Ching-Yi Nam, Harvey Man-Hok Shum, Marko Ka-Leung Chan, King-Pong Yu, Serena Sin-Wah Ng, Bibo Yang, Xiaoling Hu
Investigation on long-term effects of robot-assisted poststroke rehabilitation is challenging because of the difficulties in administration and follow-up of individuals throughout the process. A mobile hybrid neuromuscular electrical stimulation (NMES)-robot, i.e., exoneuromusculoskeleton (ENSM) was adopted for a single-group trial to investigate the long-term effects of the robot-assisted self-help
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A Bi-GRU-attention neural network to identify motor units from high-density surface electromyographic signals in real time Front. Neurosci. (IF 4.3) Pub Date : 2024-03-13 Chuang Lin, Chen Chen, Ziwei Cui, Xiujuan Zhu
To utilize surface electromyographics (sEMG) for control purposes, it is necessary to perform real-time estimation of the neural drive to the muscles, which involves real-time decomposition of the EMG signals. In this paper, we propose a Bidirectional Gate Recurrent Unit (Bi-GRU) network with attention to perform online decomposition of high-density sEMG signals. The model can give different levels
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Complex chemical reaction networks for future information processing Front. Neurosci. (IF 4.3) Pub Date : 2024-03-13 Katja-Sophia Csizi, Emanuel Lörtscher
Tackling the increasing energy demand of our society is one of the key challenges today. With the rise of artificial intelligence, information and communication technologies started to substantially contribute to this alarming trend and therefore necessitate more sustainable approaches for the future. Brain-inspired computing paradigms represent a radically new and potentially more energy-efficient
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Higher serum Lp-PLA2 is associated with cognitive impairment in Parkinson’s disease patients Front. Neurosci. (IF 4.3) Pub Date : 2024-03-12 Zubo Wu, Defeng Shu, Suyuan Wu, Pengcheng Cai, Tao Liang
ObjectiveTo explore the association between lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risk of cognitive impairment in Parkinson’s disease (PD-CI).MethodsA case–control study involving 100 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected by automatic biochemical analyzer. Based on whether Parkinson’s patients have cognitive impairment
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Small size, big problems: insights and difficulties in prenatal diagnosis of fetal microcephaly Front. Neurosci. (IF 4.3) Pub Date : 2024-03-12 Leila Haddad, Efrat Hadi, Zvi Leibovitz, Dorit Lev, Yoseph Shalev, Liat Gindes, Tally Lerman-Sagie
Microcephaly is a sign, not a diagnosis. Its incidence varies widely due to the differences in the definition and the population being studied. It is strongly related to neurodevelopmental disorders. Differences in definitions and measurement techniques between fetuses and newborns pose a great challenge for the diagnosis and prognostication of fetal microcephaly. A false positive diagnosis can result
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SGLFormer: Spiking Global-Local-Fusion Transformer with high performance Front. Neurosci. (IF 4.3) Pub Date : 2024-03-12 Han Zhang, Chenlin Zhou, Liutao Yu, Liwei Huang, Zhengyu Ma, Xiaopeng Fan, Huihui Zhou, Yonghong Tian
IntroductionSpiking Neural Networks (SNNs), inspired by brain science, offer low energy consumption and high biological plausibility with their event-driven nature. However, the current SNNs are still suffering from insufficient performance.MethodsRecognizing the brain's adeptness at information processing for various scenarios with complex neuronal connections within and across regions, as well as
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A study on EEG differences between active counting and focused breathing tasks for more sensitive detection of consciousness Front. Neurosci. (IF 4.3) Pub Date : 2024-03-12 Yimeng You, Yahui Li, Baobao Yu, Ankai Ying, Huilin Zhou, Guokun Zuo, Jialin Xu
IntroductionIn studies on consciousness detection for patients with disorders of consciousness, difference comparison of EEG responses based on active and passive task modes is difficult to sensitively detect patients’ consciousness, while a single potential analysis of EEG responses cannot comprehensively and accurately determine patients’ consciousness status. Therefore, in this paper, we designed
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Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo) Front. Neurosci. (IF 4.3) Pub Date : 2024-03-12 Wenbin Shen, Xiaoxiao Wang, Qin Li, Qingguo Ding, Hongqiang Zhang, Zheng Qian, Zhixin Sun, Xingyu Chen, Jun Zhang, Mengqi Zhao, Lina Huang, Wei Xing
ObjectiveSubthreshold depression (StD)/subsyndromal depression refers to a threatening precursor to depression. Aerobic exercise is a promising self-supportive adjunctive intervention and an effective measure for StD. Our study utilizes regional homogeneity (ReHo) to investigate the impact of aerobic exercise on resting-state brain function.MethodsA total of 78 subjects, aged between 18 and 48 years
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Cognitive impairment in Chinese traumatic brain injury patients: from challenge to future perspectives Front. Neurosci. (IF 4.3) Pub Date : 2024-03-11 Tao Liu, Shaohui Yu, Mingqi Liu, Zhihao Zhao, Jiangyuan Yuan, Zhuang Sha, Xuanhui Liu, Yu Qian, Meng Nie, Rongcai Jiang
Traumatic Brain Injury (TBI) is a prevalent form of neurological damage that may induce varying degrees of cognitive dysfunction in patients, consequently impacting their quality of life and social functioning. This article provides a mini review of the epidemiology in Chinese TBI patients and etiology of cognitive impairment. It analyzes the risk factors of cognitive impairment, discusses current
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Incorporating a-priori information in deep learning models for quantitative susceptibility mapping via adaptive convolution Front. Neurosci. (IF 4.3) Pub Date : 2024-03-11 Simon Graf, Walter A. Wohlgemuth, Andreas Deistung
Quantitative susceptibility mapping (QSM) has attracted considerable interest for tissue characterization (e.g., iron and calcium accumulation, myelination, venous vasculature) in the human brain and relies on extensive data processing of gradient-echo MRI phase images. While deep learning-based field-to-susceptibility inversion has shown great potential, the acquisition parameters applied in clinical
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Individual and group-level optimization of electric field in deep brain region during multichannel transcranial electrical stimulation Front. Neurosci. (IF 4.3) Pub Date : 2024-03-11 Hidetaka Nishimoto, Sachiko Kodera, Naofumi Otsuru, Akimasa Hirata
Electrode montage optimization for transcranial electric stimulation (tES) is a challenging topic for targeting a specific brain region. Targeting the deep brain region is difficult due to tissue inhomogeneity, resulting in complex current flow. In this study, a simplified protocol for montage optimization is proposed for multichannel tES (mc-tES). The purpose of this study was to reduce the computational
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Phybers: a package for brain tractography analysis Front. Neurosci. (IF 4.3) Pub Date : 2024-03-11 Lazara Liset González Rodríguez, Ignacio Osorio, Alejandro Cofre G., Hernan Hernandez Larzabal, Claudio Román, Cyril Poupon, Jean-François Mangin, Cecilia Hernández, Pamela Guevara
We present a Python library (Phybers) for analyzing brain tractography data. Tractography datasets contain streamlines (also called fibers) composed of 3D points representing the main white matter pathways. Several algorithms have been proposed to analyze this data, including clustering, segmentation, and visualization methods. The manipulation of tractography data is not straightforward due to the
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Interpersonal neural synchrony and mental disorders: unlocking potential pathways for clinical interventions Front. Neurosci. (IF 4.3) Pub Date : 2024-03-11 Kerstin Konrad, Christian Gerloff, Simon H. Kohl, David M. A. Mehler, Lena Mehlem, Emily L. Volbert, Maike Komorek, Alina T. Henn, Maren Boecker, Eileen Weiss, Vanessa Reindl
IntroductionInterpersonal synchronization involves the alignment of behavioral, affective, physiological, and brain states during social interactions. It facilitates empathy, emotion regulation, and prosocial commitment. Mental disorders characterized by social interaction dysfunction, such as Autism Spectrum Disorder (ASD), Reactive Attachment Disorder (RAD), and Social Anxiety Disorder (SAD), often
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Transcutaneous auricular vagus nerve stimulation with task-oriented training improves upper extremity function in patients with subacute stroke: a randomized clinical trial Front. Neurosci. (IF 4.3) Pub Date : 2024-03-08 Meng-Huan Wang, Yi-Xiu Wang, Min Xie, Li-Yan Chen, Meng-Fei He, Feng Lin, Zhong-Li Jiang
BackgroundTranscutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising brain stimulation modality in poststroke upper extremity rehabilitation. Although several studies have examined the safety and reliability of taVNS, the mechanisms underlying motor recovery in stroke patients remain unclear.ObjectivesThis study aimed to investigate the effects of taVNS paired with task-oriented
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Beta-informativeness-diffusion multilayer graph embedding for brain network analysis Front. Neurosci. (IF 4.3) Pub Date : 2024-03-08 Yin Huang, Ying Li, Yuting Yuan, Xingyu Zhang, Wenjie Yan, Ting Li, Yan Niu, Mengzhou Xu, Ting Yan, Xiaowen Li, Dandan Li, Jie Xiang, Bin Wang, Tianyi Yan
Brain network analysis provides essential insights into the diagnosis of brain disease. Integrating multiple neuroimaging modalities has been demonstrated to be more effective than using a single modality for brain network analysis. However, a majority of existing brain network analysis methods based on multiple modalities often overlook both complementary information and unique characteristics from
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Frontiers | Effects of hyperbaric oxygen therapy on autistic behaviors and GRIN2B gene expression in valproic acid-exposed rats Front. Neurosci. (IF 4.3) Pub Date : 2024-03-07 Yalda Mohtaj Khorassani, Ali Moghimi, Mohammad Reza Khakzad, Masoud Fereidoni, Delaram Hassani, Javad Torbati Gah
Introduction Autism is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, and restricted repetitive behaviors. Hyperbaric oxygen therapy (HBOT) has emerged as a potential treatment for autism, although its effects on behavior and gene expression are not well understood. The GRIN2B gene, known for its involvement in encoding a glutamate receptor subunit
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Integrative effects of transcutaneous auricular vagus nerve stimulation on esophageal motility and pharyngeal symptoms via vagal mechanisms in patients with laryngopharyngeal reflux disease Front. Neurosci. (IF 4.3) Pub Date : 2024-03-07 Yizhou Huang, Jie Liu, Chaolan Lv, Chenyu Sun, Muzi Meng, Scott Lowe, Yue Yu
Background and aimLaryngopharyngeal reflux disease (LPRD) is primarily characterized by discomfort in the pharynx and has limited treatment options. This research aimed to assess the efficacy of transcutaneous auricular vagus nerve stimulation (tVNS) in patients with LPRD and delve into the potential underlying mechanisms.MethodsA total of 44 participants, diagnosed with LPRD were divided into two
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Personalized strategies of neurostimulation: from static biomarkers to dynamic closed-loop assessment of neural function Front. Neurosci. (IF 4.3) Pub Date : 2024-03-07 Marta Carè, Michela Chiappalone, Vinícius Rosa Cota
Despite considerable advancement of first choice treatment (pharmacological, physical therapy, etc.) over many decades, neurological disorders still represent a major portion of the worldwide disease burden. Particularly concerning, the trend is that this scenario will worsen given an ever expanding and aging population. The many different methods of brain stimulation (electrical, magnetic, etc.) are
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Missense mutation of angiotensin converting enzyme gene in an Alzheimer’s disease patient: a case report Front. Neurosci. (IF 4.3) Pub Date : 2024-03-07 Mingyue He, Fan Zhang, Jing Qi, Wei Zhang
Alzheimer’s disease (AD) is the most common type of cognitive impairment in the elderly. In this report, we presented a case of a 52-year-old woman with rapid disease progression within 6 months. She was diagnosed with mild dementia according to the clinical symptoms and neuropsychological assessment results. Based on the results of neuropathological proteins in cerebrospinal fluid, cranial magnetic
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Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies Front. Neurosci. (IF 4.3) Pub Date : 2024-03-07 Valentina Caputi, Lee Hill, Melanie Figueiredo, Jelena Popov, Emily Hartung, Kara Gross Margolis, Kanish Baskaran, Papiha Joharapurkar, Michal Moshkovich, Nikhil Pai
IntroductionCritical phases of neurodevelopment and gut microbiota diversification occur in early life and both processes are impacted by genetic and environmental factors. Recent studies have shown the presence of gut microbiota alterations in neurodevelopmental disorders. Here we performed a systematic review of alterations of the intestinal microbiota composition and function in pediatric and adult
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Identification of novel hub genes for Alzheimer’s disease associated with the hippocampus using WGCNA and differential gene analysis Front. Neurosci. (IF 4.3) Pub Date : 2024-03-06 Yang Chen, Zhaoxiang Li, Xin Ge, Huandi Lv, Zuojun Geng
BackgroundAlzheimer’s disease (AD) is a common, refractory, progressive neurodegenerative disorder in which cognitive and memory deficits are highly correlated with abnormalities in hippocampal brain regions. There is still a lack of hippocampus-related markers for AD diagnosis and prevention.MethodsDifferently expressed genes were identified in the gene expression profile GSE293789 in the hippocampal
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Research on the multidimensional brain remodeling mechanisms at the level of brain regions, circuits, and networks in patients with chronic lower back pain caused by lumbar disk herniation Front. Neurosci. (IF 4.3) Pub Date : 2024-03-06 Yuan-Dong Mei, Hang Gao, Wei-Fei Chen, Wei Zhu, Chen Gu, Jun-Peng Zhang, Ji-Ming Tao, Xu-Yun Hua
IntroductionChronic lower back pain (cLBP), frequently attributed to lumbar disk herniation (LDH), imposes substantial limitations on daily activities. Despite its prevalence, the neural mechanisms underlying lower back pain remain incompletely elucidated. Functional magnetic resonance imaging (fMRI) emerges as a non-invasive modality extensively employed for investigating neuroplastic changes in neuroscience
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Combinatorial strategies for cell transplantation in traumatic spinal cord injury Front. Neurosci. (IF 4.3) Pub Date : 2024-03-06 Vipin Jagrit, Jacob Koffler, Jennifer N. Dulin
Spinal cord injury (SCI) substantially reduces the quality of life of affected individuals. Recovery of function is therefore a primary concern of the patient population and a primary goal for therapeutic interventions. Currently, even with growing numbers of clinical trials, there are still no effective treatments that can improve neurological outcomes after SCI. A large body of work has demonstrated
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SLoN: a spiking looming perception network exploiting neural encoding and processing in ON/OFF channels Front. Neurosci. (IF 4.3) Pub Date : 2024-03-06 Zhifeng Dai, Qinbing Fu, Jigen Peng, Haiyang Li
Looming perception, the ability to sense approaching objects, is crucial for the survival of humans and animals. After hundreds of millions of years of evolutionary development, biological entities have evolved efficient and robust looming perception visual systems. However, current artificial vision systems fall short of such capabilities. In this study, we propose a novel spiking neural network for
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Positive effect of microvascular proliferation on functional recovery in experimental cervical spondylotic myelopathy Front. Neurosci. (IF 4.3) Pub Date : 2024-03-06 Xu-xiang Wang, Guang-sheng Li, Kang-heng Wang, Xiao-song Hu, Yong Hu
Background and purposeCervical Spondylotic Myelopathy (CSM), the most common cause of spinal cord dysfunction globally, is a degenerative disease that results in non-violent, gradual, and long-lasting compression of the cervical spinal cord. The objective of this study was to investigate whether microvascular proliferation could positively affect neural function recovery in experimental cervical spondylotic
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Slowing Alzheimer’s disease progression through probiotic supplementation Front. Neurosci. (IF 4.3) Pub Date : 2024-03-06 Destynie Medeiros, Kristina McMurry, Melissa Pfeiffer, Kayla Newsome, Todd Testerman, Joerg Graf, Adam C. Silver, Paola Sacchetti
The lack of affordable and effective therapeutics against cognitive impairment has promoted research toward alternative approaches to the treatment of neurodegeneration. In recent years, a bidirectional pathway that allows the gut to communicate with the central nervous system has been recognized as the gut-brain axis. Alterations in the gut microbiota, a dynamic population of trillions of microorganisms
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Frontiers | Molecular pathways in experimental glaucoma models Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Klaudia Bugara, Anna Pacwa, Adrian Smedowski
Glaucoma is a complex and progressive disease that primarily affects the optic nerve axons, leading to irreversible vision loss. Although the exact molecular mechanisms underlying glaucoma pathogenesis are not fully understood, it is believed that except increased intraocular pressure, a combination of genetic and environmental factors play a role in the development of the disease. Animal models have
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Frontiers | Proportional sway-based electrotactile feedback improves lateral standing balance Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 V. S. Raghav Hari Krishna, Jeonghee Kim, Shuo-Hsiu Chang, Yoonsuck Choe, Hangue Park
Introduction Plantar cutaneous augmentation is a promising approach in balance rehabilitation by enhancing motion-dependent sensory feedback. The effect of plantar cutaneous augmentation on balance has been mainly investigated in its passive form (e.g., textured insole) or on lower-limb amputees. In this study, we tested the effect of plantar cutaneous augmentation on balance in its active form (i
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Air pollution and neurological diseases, current state highlights Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Raymond Roy, Amedeo D’Angiulli
This paper delves into the increasingly recognized yet complex relationship between air pollution and Neurological Diseases. Although the detrimental effects of air pollution on respiratory and cardiovascular health are well-documented, its impact on neurological and cognitive disorders is an emerging area of concern. In this mini review, we explore the intricate mechanisms by which various air pollutants
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A coming-of-age story: adult neurogenesis or adolescent neurogenesis in rodents? Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Jon I. Arellano, Alvaro Duque, Pasko Rakic
It is surprising that after more than a century using rodents for scientific research, there are no clear, consensual, or consistent definitions for when a mouse or a rat becomes adult. Specifically, in the field of adult hippocampal neurogenesis, where this concept is central, there is a trend to consider that puberty marks the start of adulthood and is not uncommon to find 30-day-old mice being described
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Evidence based on Mendelian randomization and colocalization analysis strengthens causal relationships between structural changes in specific brain regions and risk of amyotrophic lateral sclerosis Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Jiaying Shi, Zhaokun Wang, Ming Yi, Shengyu Xie, Xinyue Zhang, Dachang Tao, Yunqiang Liu, Yuan Yang
BackgroundAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of motor neurons in the brain and spinal cord with a poor prognosis. Previous studies have observed cognitive decline and changes in brain morphometry in ALS patients. However, it remains unclear whether the brain structural alterations contribute to the risk of ALS. In this study, we conducted
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Applications of multiphoton microscopy in imaging cerebral and retinal organoids Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Macit Emre Lacin, Murat Yildirim
Cerebral organoids, self-organizing structures with increased cellular diversity and longevity, have addressed shortcomings in mimicking human brain complexity and architecture. However, imaging intact organoids poses challenges due to size, cellular density, and light-scattering properties. Traditional one-photon microscopy faces limitations in resolution and contrast, especially for deep regions
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Electrophysiological correlates of temporal numerosity adaptation Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Paolo A. Grasso, Irene Petrizzo, Francesca Coniglio, Roberto Arrighi
IntroductionMuch research has revealed the human visual system is capable to estimate numerical quantities, rapidly and reliably, in both the spatial and the temporal domain. This ability is highly susceptible to short-term plastic phenomena related to previous exposure to visual numerical information (i.e., adaptation). However, while determinants of spatial numerosity adaptation have been widely
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Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Barkha J. Yadav-Samudrala, Benjamin L. Gorman, Karenna M. Barmada, Havilah P. Ravula, Caitlin J. Huguely, E. Diane Wallace, Michelle R. Peace, Justin L. Poklis, Wei Jiang, Sylvia Fitting
BackgroundSome evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined acute CBD effects on various behaviors and the endocannabinoid system in HIV Tat transgenic mice.MethodsTat transgenic mice (female/male) were injected with CBD (3, 10, 30 mg/kg) and assessed for antinociception, activity, coordination
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Understanding the mechanism of acupuncture in acute cerebral infraction through a proteomic analysis: protocol for a prospective randomized controlled trial Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Jiangpeng Cao, Yuanhao Du, Xiumei Yin, Na Zheng, Jiawei Han, Linling Chen, Lanyu Jia
BackgroundAcute cerebral infarction (ACI), being the predominant form of stroke, presents challenges in terms of the limited effectiveness of various treatments in improving the neurological function. Although acupuncture shows promise in addressing ACI, the availability of high-quality evidence regarding its efficacy, safety, and underlying mechanism remains insufficient. In this study, we design
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Case report: Febrile infection-related epilepsy syndrome in a 14-year-old girl with multiple organ failure and lethal outcome Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Lars Ruttkowski, Ines Wallot, Marie Korell, Elke Daur, Peter Seipelt, Andreas Leonhardt, Stefanie Weber, Nadine Mand
We report a case of an otherwise healthy 14-year-old girl with febrile infection-related epilepsy syndrome (FIRES), multiple organ failure (MOF), and ultimately a lethal outcome. This is a rare case of FIRES with MOF and consecutive death. Only a few cases have been described in the literature. The adolescent girl was initially admitted to our pediatric emergency department with a first episode of
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DCENet-based low-light image enhancement improved by spiking encoding and convLSTM Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Xinghao Wang, Qiang Wang, Lei Zhang, Yi Qu, Fan Yi, Jiayang Yu, Qiuhan Liu, Ruicong Xia, Ziling Xu, Sirong Tong
The direct utilization of low-light images hinders downstream visual tasks. Traditional low-light image enhancement (LLIE) methods, such as Retinex-based networks, require image pairs. A spiking-coding methodology called intensity-to-latency has been used to gradually acquire the structural characteristics of an image. convLSTM has been used to connect the features. This study introduces a simplified
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Sex-specific regulation of the cortical transcriptome in response to sleep deprivation Front. Neurosci. (IF 4.3) Pub Date : 2024-03-05 Tianyi Shi, Ishani Shah, Quang Dang, Lewis Taylor, Aarti Jagannath
Multiple studies have documented sex differences in sleep behaviour, however, the molecular determinants of such differences remain unknown. Furthermore, most studies addressing molecular mechanisms have been performed only in males, leaving the current state of knowledge biased towards the male sex. To address this, we studied the differences in the transcriptome of the cerebral cortex of male and
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A potential brain functional biomarker distinguishing patients with Crohn’s disease with different disease stages: a resting-state fMRI study Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Mengting Huang, Guina Ma, Yan Zou, Hui Ma, Wenliang Fan, Xin Li, Liangru Zhu, Ping Han, Huan Wang, Heshui Shi
BackgroundThe previous studies have demonstrated that patients with Crohn’s disease in remission (CD-R) have abnormal alterations in brain function. However, whether brain function changes in patients with Crohn’s disease in activity (CD-A) and the relationship with CD-R are still unclear. In this study, we aimed to investigate whether the different levels of disease activity may differentially affect
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The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Boxuan Li, Shizhe Deng, Hailun Jiang, Weiming Zhu, Bifang Zhuo, Yuzheng Du, Zhihong Meng
Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture
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Design of oscillatory neural networks by machine learning Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Tamás Rudner, Wolfgang Porod, Gyorgy Csaba
We demonstrate the utility of machine learning algorithms for the design of oscillatory neural networks (ONNs). After constructing a circuit model of the oscillators in a machine-learning-enabled simulator and performing Backpropagation through time (BPTT) for determining the coupling resistances between the ring oscillators, we demonstrate the design of associative memories and multi-layered ONN classifiers
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Upper extremity training followed by lower extremity training with a brain-computer interface rehabilitation system Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Sebastian Sieghartsleitner, Marc Sebastián-Romagosa, Woosang Cho, Johannes Grünwald, Rupert Ortner, Josef Scharinger, Kyousuke Kamada, Christoph Guger
IntroductionBrain-computer interfaces (BCIs) based on functional electrical stimulation have been used for upper extremity motor rehabilitation after stroke. However, little is known about their efficacy for multiple BCI treatments. In this study, 19 stroke patients participated in 25 upper extremity followed by 25 lower extremity BCI training sessions.MethodsPatients’ functional state was assessed
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Research on interaction and trust theory model for cockpit human-machine fusion intelligence Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Ya Duan, Yandong Cai, Ran Peng, Hua Zhao, Yue Feng, Xiaolong You
Based on Boyd’s “Observation Orientation-Decision-Action (OODA)” aerial combat theory and the principles of operational success, an analysis of the operational division patterns for cross-generational human-machine collaboration was conducted. The research proposed three stages in the development of aerial combat human-machine fusion intelligence: “Human-Machine Separation, Functional Coordination
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Responsiveness to exoskeleton loading during bimanual reaching is associated with corticospinal tract integrity in stroke Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Alexander T. Brunfeldt, Barbara S. Bregman, Peter S. Lum
BackgroundDevice-based rehabilitation of upper extremity impairment following stroke often employs one-sized-fits-all approaches that do not account for individual differences in patient characteristics.ObjectiveDetermine if corticospinal tract lesion load could explain individual differences in the responsiveness to exoskeleton loading of the arms in chronic stroke participants.MethodsFourteen stroke
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Comparison of local activation, functional connectivity, and structural connectivity in the N-back task Front. Neurosci. (IF 4.3) Pub Date : 2024-03-04 Takatoshi Satake, Ai Taki, Kazumi Kasahara, Daisuke Yoshimaru, Tomokazu Tsurugizawa
The N-back task is widely used to investigate working memory. Previous functional magnetic resonance imaging (fMRI) studies have shown that local brain activation depends on the difficulty of the N-back task. Recently, changes in functional connectivity and local activation during a task, such as a single-hand movement task, have been reported to give the distinct information. However, previous studies