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Migration Inhibition Factor Secreted by Peripheral Blood Memory B Cells Binding to CD74-CD44 Receptor Complex Drives Macrophage Behavior in Alzheimer’s Disease Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2024-03-16 Bo Liu, Wei Luo, Ling Huang, Chunying Wei, Xiaorui Huang, Jun Liu, Ran Tao, Yingmin Mo, Xuebin Li
Dysregulation of the peripheral immune system is be involved in the neuroinflammation in Alzheimer disease (AD) and accelerate the disease progression. The contribution of immune cells, particularly B cells, to AD pathogenesis has gained attention in recent research. In this study, we investigated the role of Peripheral Blood Memory B cells (PBMBs) and their secreted Migration Inhibition Factor (MIF)
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Awareness of Dementia Care Amongst the Staff Working at Day-care Centers and Nursing Homes in Macao Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2024-03-04 Sio Mui Wong, Wen Zeng, Iek Long Lo, Iek Hou Leong, Hong Lei Lou
BackgroundThe staff working at day-care centers and nursing homes are in a key frontline for early detection of older people living with dementia, however, whether the staff were well prepared and if they were appropriately trained were still little known.MethodA cross-sectional survey was conducted and the validated questionnaires exploring the awareness of dementia care, in terms of knowledge, attitude
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White Light Stimulation at Gamma Frequency to Modify the Aβ42 and tau Proteins in SH-SY5Y Cells Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2024-03-04 Yang-Pei Chang, Ching-Fang Chien, Ling-Chun Huang, Chih-Pin Chuu, Hsi-Wen Chang, Tzyh-Chyuan Hour, Yuan-Han Yang
BackgroundNon-invasive 40 Hz gamma frequency stimulation has shown improved cognition and memory recall in Alzheimer’s disease (AD).PurposeThe present study investigates the effects of white light stimulation at gamma frequency on SH-SY5Y cells using Delta M + BrainCare Light without causing discomfort.MethodsSH-SY5Y cells were exposed to The Delta M + BrainCare Light for 15, 30, 45, and 60 minutes
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Can Residents With Late-Stage Dementia Still Engage? Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2024-01-24 Scott A. Trudeau, Scott D. Slotnick, Megan E. Gately
Institutionalized persons with dementia often lack access to meaningful activity, which can lead to agitation, loneliness, and depression. Engagement in activity may improve negative symptoms but is difficult in most settings. In this study, we investigated the degree to which the Reading Buddies Program, in which occupational therapy graduate students read books with residents with dementia, engaged
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Hearing Impairment and Cognitive Function: Mediating Role of Social Isolation and Depression Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2024-01-10 Fan Wu, Chenxi Zhou
ObjectivesTo examine the relationship between hearing impairment and cognitive function and the mediating role of social isolation and depression. Methods: Data came from the 2018 China Health and Retirement Longitudinal Study wave. A self-reported item, a composite index, the 10-item Center for Epidemiological Studies Depression Scale, and the Mini-Mental State Exam were used to measure hearing impairment
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Neuropsychiatric Behavioral Assessments in Mice After Acute and Long-Term Treatments of Low-Intensity Pulsed Ultrasound Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2024-01-06 Ye Li, Yiqing Wu, Qi Luo, Xuanjie Ye, Jie Chen, Yuanlin Su, Ke Zhao, Xinmin Li, Jing Lin, Zhiqian Tong, Qi Wang, Dongwu Xu
Introduction: To evaluate whether both acute and chronic low-intensity pulsed ultrasound (LIPUS) affect brain functions of healthy male and female mice. Methods: Ultrasound (frequency: 1.5 MHz; pulse: 1.0 kHz; spatial average temporal average (SATA) intensity: 25 mW/cm2; and pulse duty cycle: 20%) was applied at mouse head in acute test for 20 minutes, and in chronic experiment for consecutive 10 days
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Associations Between Abdominal Obesity, Chewing Difficulty and Cognitive Impairment in Dementia-Free Chinese Elderly Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-05-15 Ziyue Sheng, Binte Xia, Jing Wu, Xuhao Zhao, Xindi He, Xu Wen, Changzheng Yuan, Ting Pang, Xin Xu
ObjectiveTo investigate the independent and synergistic associations between abdominal obesity, chewing difficulty and cognitive impairment in a community-dwelling older adults sample in China.Meth...
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Does Language Distance Modulate the Contribution of Bilingualism to Cognitive Reserve in Seniors? A Systematic Review Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-05-15 Maria Teresa Carthery-Goulart, Adam John Privitera, Brendan Stuart Weekes
We report a systematic review and exploratory meta-regression investigating the hypothesis that the effects of bilingualism on cognitive reserve are modulated by the distance between the pair of la...
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Diastolic Blood Pressure and Cognitive Functioning: Differences by Systolic Blood Pressure Among US Adults Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-05-13 A Mathew, RA Mesa, L Nahodyl, J Tremblay, T Rundek, A Zeki Al Hazzouri, T Elfassy
BackgroundThe role of diastolic blood pressure (DBP) with cognitive functioning is under-explored in relation to levels of systolic blood pressure (SBP).MethodsWe studied 5466 participants from the...
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Video Call Usage in Older Adults With or Without Dementia Impacted by the COVID-19 Pandemic Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-05-12 Si On Yoon, Eun Jin Paek
The usage of video calls for social connection generally increased during the COVID-19 pandemic. It remains unclear, how individuals with dementia (IWD), many of who already experienced isolation i...
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Alterations of Spatial Memory and Gut Microbiota Composition in Alzheimer’s Disease Triple-Transgenic Mice at 3, 6, and 9 Months of Age Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-05-11 Zhang Wei, Daidi Li, Jingshan Shi
Alzheimer’s disease (AD) is a progressive neurological disease. Gut microbial dysbiosis is associated with AD. This study involves the comparative assessment of spatial learning, β-amyloid peptide ...
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The Effects of Light Therapy on Sleep, Agitation and Depression in People With Dementia: A Systematic Review and Meta-analysis of Randomized Controlled Trials Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-03-16 Kenneth NK Fong, Xiangyang Ge, KH Ting, Minchen Wei, Hilda Cheung
ObjectiveTo evaluate the effects of light therapy on the alleviation of sleep disturbances, agitation and depression in people with dementia.MethodsA search was performed in PubMed, Medline, SCOPUS...
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Task-Evoked Pupillary Response as a Potential Biomarker of Dementia and Mild Cognitive Impairment: A Scoping Review Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-03-10 Michael Zeeman, Mathieu Figeys, Tolani Brimmo, Cleo Burnstad, Jasmine Hao, Esther S Kim
Pupil dilation functions as a proxy for cognitive effort and can be measured through automated pupillometry. The aim of this scoping review is to examine how individuals with cognitive impairment d...
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Burden of Illness Among Patients with Psychosis due to Dementia with Lewy Bodies and Other Dementias Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-03-09 Monica Frazer, Nazia Rashid, Scott Bunner, Ben Skoog, Victor Abler
Limited research is available on the real-world experiences of patients with dementia with Lewy bodies (DLB). This study evaluated clinical events, healthcare utilization, and healthcare costs of p...
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Utility of Amyloid Positron Emission Tomography Imaging in Older Adults With Epilepsy and Cognitive Decline Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-03-09 Rani A. Sarkis, Seth A. Gale, Hyun-Sik Yang, Alice D. Lam, Tarun Singhal, Steven Cicero, Kim Willment, Scott M. McGinnis
In older adults with cognitive decline and epilepsy, diagnosing the etiology of cognitive decline is challenging. We identified 6 subjects enrolled in the Imaging Dementia-Evidence of Amyloid Imagi...
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Development and Psychometric Evaluation of a Chinese Instrument of Knowledge, Attitude and Preventive Practice on Dementia Care in Macao Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-05 Sio Mui WONG, Wen ZENG, Iek Long LO, Chong LAM, Hong Lei LOU
BackgroundVery few instruments to integrate knowledge, attitude and practice into dementia care as a holistic perspective were available to the Chinese.MethodThis article documented the development...
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A 12-Year Comparison of Alzheimer's Dementia Patients With Their Informants in Taiwan. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Kai-Ming Jhang,Wen-Fu Wang,Kuang-Nan Hsu,Shang-Chien Huang,Sheng-Hsiang Yang,Ling-Chun Huang,Yuan-Han Yang
BACKGROUND To update the characteristics of patients with Alzheimer's disease (AD) and their informants in Taiwan and compare them from 12 years ago. METHODS 1218 patients with AD and their informants were recruited from six hospitals in Taiwan. The uniform data set version 3.0 (UDS3, form A1-A3) were administered. RESULTS Compared with the first registration from 2010-2012 (n = 691), the mean clinical
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Music Engagement as a Source of Cognitive Reserve. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Lee Wolff,Yixue Quan,Gemma Perry,William Forde Thompson
Music engagement is a ubiquitous activity that is thought to have cognitive benefits for the rapidly aging population. In the absence of robust treatment approaches for many age-related and neuropathological health issues, interest has emerged surrounding lifestyle-enriching activities, like exercise and music engagement, to build cognitive reserve across the lifespan and preserve neurocognitive function
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Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Cheng Guo,Xiaoyang Kong,Yongzhao Fan,Rihui Zhang
Previous studies have demonstrated that exercise improves cognitive function in Alzheimer's disease mice but the exact mechanism needs further studies. This research aimed to study the effects of aerobic treadmill exercise on epidermal growth factor (EGF) levels and learning and memory in d-galactose-induced aging in a mouse model. Forty male Kunming mice were analyzed in this study and randomly divided
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The Neuropathological Impacts of COVID-19: Challenges and Alternative Treatment Options for Alzheimer's Like Brain Changes on Severely SARS-CoV-2 Infected Patients. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Md Rashidur Rahman,Raushanara Akter,Sharmind Neelotpol,Iffat Islam Mayesha,Afrina Afrose
Recently, some researchers claimed neuropathological changes lead to Alzheimer's-like brains after severe infection of SARS-CoV-2. Several mechanisms have been postulated on how SARS-CoV-2 neurological damage leads to Alzheimer's disease (AD) development. Neurobiochemical changes during infection may significantly induce Alzheimer's disease in severely COVID-19 infected people. The immune system is
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Intervention and Prevention of Dementia in the Greater Bay Area (GBA) of China. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Brendan Weekes,Maria Teresa Carthery-Goulart
Reserve and resilience are recognized as essential for effective intervention and prevention of dementia. However, it is not known if these factors also protect against risk for dementia in the Greater Bay Area (GBA) of Mainland China. Studies of risk factors across regions of China provide an evidence base for future research in the GBA. However, population-based studies are rare and do not account
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The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Zhenzhen Duan,Lei Shi,Zhen Ning Tony He,Chunxiang Kuang,Tianxiong Han,Qing Yang
Alzheimer's disease (AD) is an inflammatory associated disease, in which dysregulated kynurenine pathway (KP) plays a key role. Through KP, L-tryptophan is catabolized into neurotoxic and neuroprotective metabolites. The overactivation of indolamine 2,3-dioxygenase1 (IDO1), the first rate-limiting enzyme of KP, and the abnormal accumulation of KP metabolites have been noted in AD, and blocking IDO1
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Usability and Acceptability of Social Robot Pets Among Community-Dwelling Veterans Living With Dementia and Their Caregivers. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Melissa L Harris-Gersten,Judith M Davagnino,Edwin R Alcorn,S Nicole Hastings
Social robot pets promote engagement and psychosocial well-being among older adults, yet little is known about their use among community-dwelling Veterans living with dementia. This programmatic evaluation used a within subjects, pre-post design to examine the usability (frequency of use, frequency of caregiver reminders) and acceptability (benefit, satisfaction) of social robot pets among Veterans
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The Use of Verbal and Nonverbal Memory Tests for Alzheimer's Disease Screening in Taiwan Chinese. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Kuan-Ying Li,Ching-Fang Chien,Tang-Wei Huang,Yuan-Han Yang
Patients with Alzheimer's disease typically have initial deficits in memory. Memory testing can be categorized as verbal or nonverbal by the modality of the stimuli used. We compared the discriminative validity of selected verbal and nonverbal memory tests between non-dementia and Alzheimer's disease in Taiwan. Ninety-eight patients with mild Alzheimer's disease and 269 non-dementia individuals underwent
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Measurement of Five Emotions Defined by Traditional Chinese Medicine With a Focus on Preventing Mild Cognitive Impairment. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Xiaoyu Wu,Jiaojiao Zou,Ziqiu He,Youou Huang,Bin Zhou,Yuemin Zhou,Joe Kodama,Yuquan Lu
Objectives: This study aimed to develop a novel Measurement of the Five Emotions (MFE) based on traditional Chinese medicine for assessing cognitive impairment in elderly individuals. Methods: Surveys were collected from 184 participants, over 65 years of age, who were residents of Kyoto City, Japan. The surveys included the Measurement of the Five Emotions (MFE) and the Dementia Assessment Sheet for
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Anti-Aging of the Nervous System and Related Neurodegenerative Diseases With Chinese Herbal Medicine. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Xiaohui Du,Nanbin Lou,Sinan Hu,Ruopeng Xiao,Chu Chu,Qiankai Huang,Lin Lu,Shanshan Li,Jing Yang
Human beings have always pursued a prolonged lifespan, while the aging of the nervous system is associated with a large variety of diseases. Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly. Therefore, there is an urgent need for the prevention and treatment of nervous system aging. Chinese herbal medicines
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Risk Factors for Delirium Superimposed on Dementia in Elderly Patients in Comprehensive Ward. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Qifan Xiao,Suqiao Zhang,Chenlu Li,Yuqing Zhu
OBJECTIVE To investigate the incidence of delirium and its related risk factors in patients with senile dementia during hospitalization. METHODS A retrospective analysis of clinical data of 157 patients over 65 with cognitive impairment who were hospitalized in the comprehensive ward from October 2019 to February 2023 was conducted. Patients were assigned into delirium and non-delirium groups according
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Comparing Lookback Periods to Ascertain Alzheimer's Disease and Related Dementias. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Zachary J Kunicki,Thomas Bayer,Lan Jiang,Melanie L Bozzay,McKenzie J Quinn,Alyssa N De Vito,Sheina Emrani,Sebhat Erqou,John E McGeary,Andrew R Zullo,Matthew S Duprey,Mriganka Singh,Jennifer M Primack,Catherine M Kelso,Wen-Chih Wu,James L Rudolph
Claims data are a valuable resource for studying Alzheimer's disease and related dementias (ADRD). Alzheimer's disease and related dementias is often identified using a list of claims codes and a fixed lookback period of 3 years of data. However, a 1-year lookback or an approach using all-available lookback data could be beneficial based on different research questions. Thus, the purpose of this study
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Changes in Selected Cognitive and Motor Skills as Well as the Quality of Life After a 24-Week Multidimensional Music-Based Exercise Program in People With Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Alexander Prinz,Anneke Schumacher,Kerstin Witte
The loss of independence is one of the greatest consequences of dementia. Multidimensional music-based exercise programs could counteract. The present study investigates the effects of such a program on people with dementia and bases on a 24-week intervention with three measurement time points. Sixty-nine people with dementia were randomly assigned to the intervention (n = 43) and control group (n
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The Association Between Subjective Mental Impairment and Objective Cognitive Performance in Non-Demented, Very Mild and Mild Demented Individuals. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Ling-Chun Huang,Yuan-Han Yang
OBJECTIVES Explore associations between subjective mental impairment, objective cognitive performance, and subsequent decline in older individuals with different cognitive statuses in Taiwan. METHODS Use self-reported questionnaire and cognitive abilities screening instrument to assess subjective and objective cognitive function. Categorize participants as reporters or non-reporters based on subjective
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A Study on the Effect of Traditional Chinese Exercise Combined With Rhythm Training on the Intervention of Older Adults With Mild Cognitive Impairment. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Qiang Zhang,Menglong Zhu,Lili Huang,Miao Zhu,Xiaolei Liu,Ping Zhou,Tao Meng
BACKGROUND To examine the effect of combination exercise program on cognitive function of older adults with mild cognitive impairment (MCI), and identify biomarkers associated with improvement of cognitive functions. METHODS Subjects were 42 older adults (ages, 60-80 years) with MCI. The subjects were randomly classified to traditional Chinese exercise combined with rhythm training group (TCE + RTG
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Tailored Music Listening in Persons With Dementia: A Feasibility Randomized Clinical Trial. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Darina V Petrovsky,Joke Bradt,Miranda V McPhillips,Justine S Sefcik,Laura N Gitlin,Nancy A Hodgson
Introduction: This study examined the feasibility, acceptability, and preliminary efficacy of tailored music listening intervention on sleep disturbances in older adults with dementia and their caregivers. Methods: We randomly assigned 33 older adults with dementia (mean age 71.7 [SD: 7.1], 72.7% female, 81.8% African American/Black) and their caregivers (mean age 58.4 [SD: 16.7], 72.7% female, 84
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Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Ginny Natale,Yun Zhang,Douglas William Hanes,Sean Ap Clouston
OBJECTIVE We estimated the conversion from cognitively normal to mild cognitive impairment (MCI) to probable dementia and death for underweight, normal, overweight, and obese older adults, where the timing of examinations is associated with the severity of dementia. METHODS We analyzed six waves of the National Health and Aging Trends Study (NHATS). Body mass (BMI) was computed from height and weight
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Dendrobium Nobile Polysaccharides Attenuates Ferroptosis and Improves Cognitive Function in Vascular Dementia Rats. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Min Ming,Weihua Hu,Gaosheng Xie,Jianping Chen,Ying Huang
INTRODUCTION To investigate the neuroprotective effect and mechanism of Dendrobium nobile polysaccharide (DNP) on vascular dementia (VD) rats. METHODS VD model rats were prepared by permanent ligation of bilateral common carotid arteries. Cognitive function was tested by morris water maze test, mitochondrial morphology and ultrastructure of hippocampal synapses were tested by transmission electron
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Associations of Telomere Length and Change With Cognitive Decline Were Modified by Sex and Race: The REGARDS Study. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Cheng Chen,Keming Yang,Hongmei Nan,Frederick Unverzagt,Leslie A McClure,Marguerite R Irvin,Suzanne Judd,Mary Cushman,Debora Kamin Mukaz,James E Klaunig,Mary E D'Alton,Ka Kahe
INTRODUCTION We examined the associations of baseline telomere length (TL) and TL change with cognitive function over time in older US adults, as well as differences by sex and race. METHODS A total of 1820 cognitively healthy individuals (median baseline age: 63 years) were included. Telomere length was measured using qPCR-based method at baseline and among 614 participants in the follow-up examination
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Development of the Observable Well-Being in Living With Dementia-Scale. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Kristine G Madsø,Nancy A Pachana,Inger H Nordhus
The Observable Well-being in Living with Dementia-Scale was developed to address conceptual and methodological issues in current observational scales for music therapy. Creative interventions may receive lowered scores, as existing instruments rely heavily on verbal behavior. Methods were (1) Systematic review of observational instruments: (2) field work with music therapy and sociable interactions
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Quality of Life Ratings and Proxy Bias in Primary Progressive Aphasia: Two Sides to the Story? Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Leanne Ruggero,Karen Croot,Lyndsey Nickels
A valid measure of quality of life is important for clinical goal setting and for evaluating interventions. In the amnestic dementias, proxy-raters (e.g. friends, families, clinicians) typically rate quality of life lower than the self-ratings given by the person with dementia - a proxy bias. This study investigated whether the same proxy bias occurs in Primary Progressive Aphasia (PPA), a language-led
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Effects of Physical Exercise Program for Older Family Caregivers of Persons With Dementia. Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2023-01-01 Ji-Yeon Kim,Sunghee H Tak,Jaegyeong Lee,Hyein Choi
Self-efficacy plays a major role in improving health behaviors. The purpose of this study was to examine the effects of a physical activity program that utilized four self-efficacy resources in older family caregivers of persons with dementia. Quasi-experimental pretest-posttest design with control group was used. Study participants were 64 family caregivers aged 60 years or older. The intervention
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The Correlations Between Serum Hcy Level and Seizures and Cognitive Function in Patients After Stroke Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-12-21 Chen Lan, Zhiqiang Huang, Xinxin Luo, Yongcheng Zhang
BackgroundsPost-stroke cognitive dysfunction (PSCI), a set of illnesses ranging from moderate cognitive impairment to dementia, which is one of the most prevalent consequences following a stroke. H...
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Physical Exercise Exerts Neuroprotective Effect on Memory Impairment by Mitigate the Decline of Striatum Catecholamine and Spine Density in a Vascular Dementia Rat Model Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-12-14 Hangzhou Ren, Zhongyuan Zhang, Jianwei Zhang
ObjectiveThe present study aims to investigate the underlying neurochemical mechanism of physical exercise on striatum synapsis and memory function in vascular dementia model.Methods32 Sprague-Dawl...
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Prophylactic Effects of Sub-anesthesia Ketamine on Cognitive Decline, Neuroinflammation, and Oxidative Stress in Elderly Mice Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-12-06 Minmin Chen, Yinqiu Han, Bin Que, Rong Zhou, Jianhui Gan, Xiaoyun Dong
Cognitive dysfunction is a very common postoperative complication. The study aimed at investigating the effects of ketamine on the cognition of elderly mice after anesthesia and surgery (AS). We re...
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Opposite Roles of Co-enzyme Q10 and Formaldehyde in Neurodegenerative Diseases Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-12-01 Jinan Xu, Xingjiang Jin, Zuting Ye, Dandan Wang, Hang Zhao, Zhiqian Tong
Most of neurodegenerative diseases (NDD) have no cure. The common etiology of neurodegenerations is unclear. Air pollutant-gaseous formaldehyde is notoriously known to induce demyelination and cogn...
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The Role of Preparedness for Caregiving on the Relationship Between Caregiver Distress and Potentially Harmful Behaviors Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-11-25 David W. Hancock, Sara Czaja, Richard Schulz
This work extends research suggesting a link between indicators of distress among informal caregivers (CG) (e.g., depression and burden), and potentially harmful behaviors (PHB), including feeling ...
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Does Long-Term Shift Work Increase the Risk of Dementia? A Systematic Review and Meta-Analysis Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-11-23 Yang Hai, Ying Xue, Yu-hong Wang
Background: Shift work is associated with impaired sleep quality and disrupted circadian rhythms, but the way in which it increases the risk of dementia remains controversial. We conducted a system...
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The Willingness to Help People With Dementia Symptoms Among Four Occupation Practitioners in Macao Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-11-15 Sok Leng Che, Jianwei Wu, Yao-Chen Chuang, Iat Kio Van, Sok Man Leong
BackgroundDementia-friendly community has been promoted in Macao since 2016. There is no study investigating the understanding of nor attitudes towards dementia among public contact staff in Macao....
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Cognitive Assessment in Culturally, Linguistically, and Educationally Diverse Older Populations in Europe Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-11-03 T. Rune Nielsen
Due to increasing cultural, linguistic, and educational diversity in older populations across Europe, accurate assessment of cognitive functioning in people from diverse backgrounds becomes increas...
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The Tree Drawing Test in Evolution: An Explorative Longitudinal Study in Alzheimer’s Disease Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-11-01 Michelangelo Stanzani Maserati, Marialaura Matacena, Flavia Baccari, Corrado Zenesini, Roberto Gallassi, Sabina Capellari, Corrado Matacena
ObjectiveTo study the evolution of the Tree Drawing Test (TDT) in a group of Alzheimer’s disease (AD) patients.MethodsA total of 33 AD patients were consecutively evaluated by Mini Mental State Eva...
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Association of Dementia Severity and Caregiver Support With Early Discharge From Home Health Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-10-14 Sara Knox, Allen Haas, Brian Downer, Kenneth J. Ottenbacher
IntroductionThe objective of this study was to examine the relationship between dementia severity and early discharge from home health.MethodsThis was a retrospective study of 100% national Medicar...
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The Association Between Dextromethorphan Use and the Risk of Dementia Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-09-14 Chia-Yuan Chen, Chi-Hsiang Chung, Wu-Chien Chien, Hsin-Chien Chen
Dementia is one of neurodegenerative disease without preventive medicine currently. Dextromethorphan (DXM) has been reported to reduce neuronal damage and neurodegeneration in animal and human mode...
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Acetoacetate Improves Memory in Alzheimer’s Mice via Promoting Brain-Derived Neurotrophic Factor and Inhibiting Inflammation Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-09-14 Xiao-Jun Wu, Qin-Qin Shu, Bin Wang, Lan Dong, Bin Hao
The ketone bodies, especially the β-hydroxybutyrate, had been shown to modulate the function of the central nervous system and prevent the pathological progression of Alzheimer’s disease (AD). Howe...
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The Cognitive and Language Profile of Dementia with Lewy Bodies Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-09-10 Joël Macoir
Dementia with Lewy bodies (DLB) is a major neurocognitive disorder (MNCD) that is primarily characterized by motor, cognitive, and behavioral symptoms. Although not dominant in the clinical portrai...
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Population-Based Studies in Dementia and Ageing Research: A Local and National Experience in Cambridgeshire and the UK Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-08-24 Carol Brayne, Yu-Tzu Wu
Dementia has been recognised as a key challenge in many ageing societies across the world. Several population-based studies have been developed to investigate dementia and cognitive ageing from per...
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Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer’s Disease Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-07-17 Haiyuan Qiu, Qiuyan Weng
Background: We aimed to make an integrated analysis of published transcriptome and DNA methylation dataset to ascertain the key differentially methylated and differentially expressed genes for Alzh...
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The Influence of Dementia Beliefs and Knowledge on Perceived Dementia Worry: An Empirical Study Among Adults in Rural China Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-07-14 Meng Liu, Fei Sun, Chuntian Lu, Jinchen Xie
Alzheimer’s disease and related dementias are more prevalent in rural areas than in urban areas in China. This study aims to examine the role of dementia beliefs and knowledge in influencing dement...
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Urinary AD7c-NTP Evaluates Cognition Impairment and Differentially Diagnoses AD and MCI Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-07-14 Ming-Ran Xu, Rong-Fang Dai, Qing-Qi Wei, Jun Wang, Yue-Ying Feng, Ying Hu
The AD7c-NTP is a promising biomarker for AD diagnosis. However, the exact urinary AD7c-NTP concentration to differentiate AD from the mild cognitive impairment (MCI) remains inconclusive. We enrol...
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Progesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer’s Disease Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-06-22 Xin Xu, Xiangyan Ruan, Rui Ju, Zhikun Wang, Yu Yang, Jiaojiao Cheng, Muqing Gu, Alfred O. Mueck
Cerebrovascular changes occur in Alzheimer’s disease (AD). The progesterone receptor membrane component-1 (PGRMC1) is a well identified hormone receptor with multiple functions in AD. This study ai...
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A Functional Assessment Tool to Distinguish Controls From Alzheimer’s Disease in Lima, Peru Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-06-03 Nilton Custodio, Rosa Montesinos, Diego Chambergo-Michilot, Eder Herrera-Perez, Maritza Pintado-Caipa, Wendy Seminario G, José Cuenca, Laura Mesía, Virgilio E Failoc-Rojas, Monica M Diaz
BackgroundThe Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scale is a versatile functional assessment tool for patients with Alzheimer’s disease (ad). We evaluated it...
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Bilingualism as a Contributor to Cognitive Reserve: What it Can do and What it Cannot do Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-04-26 Matthias Berkes, Ellen Bialystok
In the absence of effective pharmacological interventions for the prevention of dementia, attention has turned to lifestyle factors that contribute to cognitive reserve. Although cognitive reserve ...
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Validation of Picture Free and Cued Selective Reminding Test for Illiteracy in Lima, Peru Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-04-24 Rosa Montesinos, Jose F. Parodi, Monica M. Diaz, Eder Herrera-Perez, Elizabeth Valeriano-Lorenzo, Ambar Soto, Carolina Delgado, Andrea Slachevsky, Nilton Custodio
Dementia in Latin America is a crucial public health problem. Identifying brief cognitive screening (BCS) tools for the primary care setting is crucial, particularly for illiterate individuals. We evaluated tool performance characteristics and validated the free and total recall sections of the Free and Cued Selective Reminding Test-Picture version (FCSRT-Picture) to discriminate between 63 patients
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The Involvement of lncRNA HOTAIR/miR-130a-3p Axis in the Regulation of Voluntary Exercise on Cognition and Inflammation of Alzheimer’s Disease Am. J. Alzheimers Dis. Other Demen. (IF 3.4) Pub Date : 2022-04-20 Jianxia Lu, Lihua Liu, Jin Chen, Juan Zhi, Jiabin Li, Le Li, Zhongli Jiang
Background Alzheimer’s disease (AD) is an age-related neurodegenerative disease and exercises might mitigate the progression of AD. This investigation aimed to manifest the potential mechanism of exercises in AD. Methods Morris water maze (MWM) test was conducted to evaluate the cognitive function in APP/PS1 mice. Quantitative real-time PCR was performed to detect the expression of HOTAIR and miR-130a-3p