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  • The ethics of neuro-oncology in the era of COVID-19: Lessons to be learned
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-29
    Sunit Das

    In this second installment of the Society for Neuro-Oncology’s series of editorials to commemorate our 25th anniversary, we focus on one of the most successful initiatives from our first quarter-century, SNO’s flagship journal, Neuro-Oncology, a visionary creation of Dr. Darell Bigner, the founding Editor-in-Chief.

    更新日期:2020-05-29
  • Deregulated expression of the imprinted DLK1-DIO3 region in Glioblastoma Stem-like Cells: tumor suppressor role of lncRNA MEG3
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-27
    Mariachiara Buccarelli; Valentina Lulli; Alessandro Giuliani; Michele Signore; Maurizio Martini; Quintino G D'Alessandris; Stefano Giannetti; Agnese Novelli; Ramona Ilari; Giorgio Giurato; Alessandra Boe; Giorgia Castellani; Serena Spartano; Giuseppe Marangi; Mauro Biffoni; Maurizio Genuardi; Roberto Pallini; Giovanna Marziali; Lucia Ricci-Vitiani

    Glioblastoma (GBM) stem-like cells (GSCs) are thought to be responsible for the maintenance and aggressiveness of GBM, the most common primary brain tumor in adults. This study aims at elucidating the involvement of deregulations within the imprinted DLK-DIO3 region on chromosome 14q32 in GBM pathogenesis.

    更新日期:2020-05-27
  • Ad-CD40L mobilizes CD4 T cells for the treatment of brainstem tumors
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-27
    Phonphimon Wongthida; Matthew R Schuelke; Christopher B Driscoll; Timothy Kottke; Jill M Thompson; Jason Tonne; Cathy Stone; Amanda L Huff; Cynthia Wetmore; James A Davies; Alan L Parker; Laura Evgin; Richard G Vile

    Diffuse Midline Glioma, formerly Diffuse Intrinsic Pontine Glioma (DIPG), is the deadliest pediatric brainstem tumor with median survival of less than one year. Here, we investigated 1) whether direct delivery of adenovirus expressing CD40L (Ad-CD40L) to brainstem tumors would induce immune-mediated tumor clearance and, 2) if so, whether therapy would be associated with a manageable toxicity due to

    更新日期:2020-05-27
  • Inhibition of SETMAR-H3K36me2-NHEJ repair axis in residual disease cells prevent glioblastoma recurrence
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-27
    Ekjot Kaur; Jyothi Nair; Atanu Ghorai; Saket V Mishra; Anagha Achareker; Madhura Ketkar; Debashmita Sarkar; Sameer Salunkhe; Jacinth Rajendra; Nilesh Gardi; Sanket Desai; Prajish Iyer; Rahul Thorat; Amit Dutt; Aliasgar Moiyadi; Shilpee Dutt

    Residual disease of glioblastoma (GBM) causes recurrence. However, targeting residual cells have failed due to their inaccessibility and our lack of understanding their survival mechanisms to radiation therapy. Here we deciphered residual cell specific survival mechanism essential for GBM relapse.

    更新日期:2020-05-27
  • Erratum: Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses.
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-19
    Andrea Comba,Patrick J Dunn,Anna E Argento,Padma Kadiyala,Maria Ventosa,Priti Patel,Daniel B Zamler,Felipe J Nunez,Lili Zhao,Maria G Castro,Pedro R Lowenstein

    In this second installment of the Society for Neuro-Oncology’s series of editorials to commemorate our 25th anniversary, we focus on one of the most successful initiatives from our first quarter-century, SNO’s flagship journal, Neuro-Oncology, a visionary creation of Dr. Darell Bigner, the founding Editor-in-Chief.

    更新日期:2020-05-19
  • Highlights from the Literature
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-19
    Venere M, Zadeh G, Puduvalli V, et al.

    In this second installment of the Society for Neuro-Oncology’s series of editorials to commemorate our 25th anniversary, we focus on one of the most successful initiatives from our first quarter-century, SNO’s flagship journal, Neuro-Oncology, a visionary creation of Dr. Darell Bigner, the founding Editor-in-Chief.

    更新日期:2020-05-19
  • Forthcoming Meetings
    Neuro Oncol. (IF 10.091) Pub Date : 2020-04-15

    Edited by Albert H. Kim and Jennie W. Taylor

    更新日期:2020-05-15
  • Bridging the treatment gap in infant medulloblastoma: Molecularly informed outcomes of a globally feasible regimen.
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-15
    Lorena V Baroni,Claudia Sampor,Adriana Gonzalez,Fabiana Lubieniecki,Gabriela Lamas,Carlos Rugilo,Ute Bartels,Ayala Heled,Kyle S Smith,Paul A Northcott,Eric Bouffet,Daniel Alderete,Vijay Ramaswamy

    BACKGROUND Infant medulloblastoma represents an enormous challenge in neuro-oncology, due to their simultaneous high-risk of recurrence and high risk of severe neurodevelopmental sequelae with craniospinal irradiation. Currently infant medulloblastoma are treated with intensified protocols, either comprising intraventricular methotrexate or autologous transplant, both of which carry significant morbidity

    更新日期:2020-05-15
  • Celebrating SNO's official journal, Neuro-Oncology.
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-15
    Monica Venere,Gelareh Zadeh,Vinay Puduvalli,Chas Haynes

    In this second installment of the Society for Neuro-Oncology’s series of editorials to commemorate our 25th anniversary, we focus on one of the most successful initiatives from our first quarter-century, SNO’s flagship journal, Neuro-Oncology, a visionary creation of Dr. Darell Bigner, the founding Editor-in-Chief.

    更新日期:2020-05-15
  • Forthcoming Meetings
    Neuro Oncol. (IF 10.091) Pub Date : 2020-05-15

    Edited by Jennie W. Taylor