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Triple platelet inhibition in intracranial thrombectomy with additional acute cervical stent angioplasty due to tandem lesion: a retrospective single-center analysis BMC Neurol. (IF 2.6) Pub Date : 2024-03-18 Ali Khanafer, Hans Henkes, Philipp Bücke, Florian Hennersdorf, Hansjörg Bäzner, Michael Forsting, Philipp von Gottberg
Acute stroke treatment with intracranial thrombectomy and treatment of ipsilateral carotid artery stenosis/occlusion (“tandem lesion”, TL) in one session is considered safe. However, the risk of stent restenosis after TL treatment is high, and antiplatelet therapy (APT) preventing restenosis must be well balanced to avoid intracranial hemorrhage. We investigated the safety and 90-day outcome of patients
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Investigating the causal relationship between immune cell and Alzheimer’s disease: a mendelian randomization analysis BMC Neurol. (IF 2.6) Pub Date : 2024-03-18 Min Shen, Linlin Zhang, Chen Chen, Xiaocen Wei, Yuning Ma, Yuxia Ma
Complex interactions between the immune system and the brain may affect neural development, survival, and function, with etiological and therapeutic implications for neurodegenerative diseases. However, previous studies investigating the association between immune inflammation and Alzheimer’s disease (AD) have yielded inconsistent results. We applied Mendelian randomization (MR) to examine the causal
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Brain frailty associated with stroke events in anterior circulation large artery occlusion BMC Neurol. (IF 2.6) Pub Date : 2024-03-18 Jing Tian, Kun Zhang, Junzhao Cui, Jin Qin, Binbin Wang, Lixia Zhou, Tong Li, Kailin Bu, Zhongzhong Li, Lin Liu, Qisong Wang, Si Yuan, Lina Ma, Ye Wang, Rui Wang, Chaoyue Meng, Biyi Zhou, Li Guo, Xiaoyun Liu
To investigate the factors associated with brain frailty and the effect of brain frailty in patients with anterior circulation large artery occlusion (AC-LAO). 1100 patients with AC-LVO consecutively admitted to the Second Hospital of Hebei Medical University, North China between June 2016 and April 2018 were retrospectively analyzed. The variables associated with brain frailty and stroke outcome were
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Defining clinical endpoints in limb girdle muscular dystrophy: a GRASP-LGMD study BMC Neurol. (IF 2.6) Pub Date : 2024-03-15 Amy Doody, Lindsay Alfano, Jordi Diaz-Manera, Linda Lowes, Tahseen Mozaffar, Katherine D. Mathews, Conrad C. Weihl, Matthew Wicklund, Man Hung, Jeffrey Statland, Nicholas E. Johnson
The Limb Girdle Muscular Dystrophies (LGMDs) are characterized by progressive weakness of the shoulder and hip girdle muscles as a result of over 30 different genetic mutations. This study is designed to develop clinical outcome assessments across the group of disorders. The primary goal of this study is to evaluate the utility of a set of outcome measures on a wide range of LGMD phenotypes and ability
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Exploring the role of mitochondrial-associated and peripheral neuropathy genes in the pathogenesis of diabetic peripheral neuropathy BMC Neurol. (IF 2.6) Pub Date : 2024-03-13 Ruojing Bai, Yuanyuan Luo
Diabetic peripheral neuropathy (DPN) is a prevalent and serious complication of diabetes mellitus, impacting the nerves in the limbs and leading to symptoms like pain, numbness, and diminished function. While the exact molecular and immune mechanisms underlying DPN remain incompletely understood, recent findings indicate that mitochondrial dysfunction may play a role in the advancement of this diabetic
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Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease BMC Neurol. (IF 2.6) Pub Date : 2024-03-12 Hong Jin, Yiheng Du, Jiahui Yan, Jinru Zhang, Xiaoyu Cheng, Chengjie Mao, Jing Chen, Chun-feng Liu
Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose of this study was to examine the relationship between dyskinesia, OAB, and clinical characteristics among individuals with PD. 1338 PD patients were included in the present study. Demographic features
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Optimized MLPA workflow for spinal muscular atrophy diagnosis: identification of a novel variant, NC_000005.10:g.(70919941_70927324)del in isolated exon 1 of SMN1 gene through long-range PCR BMC Neurol. (IF 2.6) Pub Date : 2024-03-11 Mei Yao, Liya Jiang, Yicheng Yu, Yiqin Cui, Yuwei Chen, Dongming Zhou, Feng Gao, Shanshan Mao
Spinal muscular atrophy (SMA) is a rare autosomal recessive hereditary neuromuscular disease caused by survival motor neuron 1 (SMN1) gene deletion or mutation. Homozygous deletions of exon 7 in SMN1 result in 95% of SMA cases, while the remaining 5% are caused by other pathogenic variants of SMN1. We analyzed two SMA-suspected cases that were collected, with no SMN1 gene deletion and point mutation
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Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease BMC Neurol. (IF 2.6) Pub Date : 2024-03-11 Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi, Katsuya Satoh
Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging. Even though real-time quaking-induced conversion (RT-QuIC) assay is suitable for detecting prion seeding activity in a variety of specimens, it shows lower accuracy when whole blood
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A systematic review and meta-analysis of clinical efficacy of early and late rehabilitation interventions for ischemic stroke BMC Neurol. (IF 2.6) Pub Date : 2024-03-08 Xufang Wei, Shengtong Sun, Manyu Zhang, Zhenqiang Zhao
At present, stroke has become the first cause of death and disability among Chinese adults. With the coming of the aging population in China, the disease burden brought by stroke will be increasingly aggravated. And stroke is a leading cause of disability. There is a golden plastic period after stroke, during which timely and safe intervention and rehabilitation therapy can effectively improve the
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High thrombin-activatable fibrinolysis inhibitor expression in thrombi from stroke patients in elevated estrogen states BMC Neurol. (IF 2.6) Pub Date : 2024-03-07 Tamanna Agarwal, Oana Madalina Mereuta, Sherief Ghozy, Jorge L Arturo Larco, Cem Bilgin, Ram Kadirvel, Waleed Brinjikji, David F Kallmes
The risk of acute ischemic stroke (AIS) associated with high estrogen states, including pregnant patients and those using oral contraceptives, has been well documented. We described the histological composition of thrombi collected in these cases. From a prospective tissue registry (STRIP registry) of thrombi retrieved during mechanical thrombectomy for AIS, we identified 5 patients with high estrogen
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Neuroanatomical and neurocognitive correlates of delusion in Alzheimer’s disease and mild cognitive impairment BMC Neurol. (IF 2.6) Pub Date : 2024-03-06 Seyul Kwak, Hairin Kim, Keun You Kim, Da Young Oh, Dasom Lee, Gieun Nam, Jun-Young Lee
Neuropsychiatric symptoms and delusions are highly prevalent among people with dementia. However, multiple roots of neurobiological bases and shared neural basis of delusion and cognitive function remain to be characterized. By utilizing a fine-grained multivariable approach, we investigated distinct neuroanatomical correlates of delusion symptoms across a large population of dementing illnesses. In
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Association between serum triglycerides and stroke type, severity, and prognosis. Analysis in 6558 patients BMC Neurol. (IF 2.6) Pub Date : 2024-03-05 Naveed Akhtar, Rajvir Singh, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Ty Uy, Sarah Treit, Ashfaq Shuaib
Hypertriglyceridemia (HT) may increase the risk of stroke. Limited studies have shown that stroke severity and infarction size are smaller in patients with HT. We explored the relationship between triglyceride levels and stroke risk factors, severity and outcome in a large prospective database. Prospective Cross-sectional study. We retrospectively interrogated the Qatar Stroke Database in all patients
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Expanded clinical phenotype and untargeted metabolomics analysis in RARS2-related mitochondrial disorder: a case report BMC Neurol. (IF 2.6) Pub Date : 2024-03-04 Ameya S. Walimbe, Keren Machol, Stephen F. Kralik, Elizabeth A. Mizerik, Yoel Gofin, Mir Reza Bekheirnia, Charul Gijavanekar, Sarah H. Elsea, Lisa T. Emrick, Fernando Scaglia
RARS2-related mitochondrial disorder is an autosomal recessive mitochondrial encephalopathy caused by biallelic pathogenic variants in the gene encoding the mitochondrial arginyl-transfer RNA synthetase 2 (RARS2, MIM *611524, NM_020320.5). RARS2 catalyzes the transfer of L-arginine to its cognate tRNA during the translation of mitochondrially-encoded proteins. The classical presentation of RARS2-related
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The associations between peripheral inflammatory and lipid parameters, white matter hyperintensity, and cognitive function in patients with non-disabling ischemic cerebrovascular events BMC Neurol. (IF 2.6) Pub Date : 2024-03-04 Binghan Li, Zhengsheng Gu, Weisen Wang, Bingying Du, Chenghao Wu, Bin Li, Tianren Wang, Ge Yin, Xin Gao, Jingjing Chen, Xiaoying Bi, Hailing Zhang, Xu Sun
The global prevalence of VCI has increased steadily in recent years, but diagnostic biomarkers for VCI in patients with non-disabling ischemic cerebrovascular incidents (NICE) remain indefinite. The primary objective of this research was to investigate the relationship between peripheral serological markers, white matter damage, and cognitive function in individuals with NICE. We collected clinical
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Relationship between glycated hemoglobin levels and three-month outcomes in acute ischemic stroke patients with or without diabetes: a prospective Korean cohort study BMC Neurol. (IF 2.6) Pub Date : 2024-03-04 Changchun Cao, Tony Bowei Wang, Haofei Hu, Yong Han, Xiaohua Zhang, Yulong Wang
In patients experiencing acute ischemic stroke, there is ongoing debate surrounding the connection between chronic hyperglycemic status and their initial clinical outcomes. Our objective was to examine the connection between glycated hemoglobin (HbA1c) levels and adverse clinical outcomes at both 3-months adverse clinical outcomes in individuals with acute ischemic stroke (AIS) with and without diabetes
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Questionnaire-based study of COVID-19 vaccination induced headache: evidence of clusters of adverse events BMC Neurol. (IF 2.6) Pub Date : 2024-03-02 Qiao Zhou, Thomas Eggert, Ana Zhelyazkova, Alexander Choukér, Kristina Adorjan, Andreas Straube
The adverse events (AEs) after a Coronavirus disease 2019 (Covid-19) Pfizer-Biotech mRNA vaccination present a medical and epidemiological issue of increasing interest. Headache is the most frequent neurological adverse effect and generally the third most common adverse event after a Covid-19 vaccination, but only a few studies focus on the link between headache and other AEs after vaccination. This
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Hand knob sign in osmotic demyelinating syndrome BMC Neurol. (IF 2.6) Pub Date : 2024-03-02 Noppachai Siranart, Pannathorn Nakaphan, Vasinee Viarasilpa, Prakit Anukoolwittaya, Pasin Hemachudha
Osmotic demyelinating syndrome, commonly recognized as a consequence of the rapid correction of hyponatremia, has been known to cause motor, neuropsychiatric, or extrapyramidal symptoms. We reported a patient with an unusual presentation involving bilateral hand weakness, and pseudobulbar affect. The imaging was compatible with osmotic demyelinating syndrome with bilateral hand knob lesions, despite
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Case identification of non-traumatic brain injury in youth using linked population data BMC Neurol. (IF 2.6) Pub Date : 2024-03-02 Rebecca F Slykerman, Betony E Clasby, Jimmy Chong, Kathryn Edward, Barry J Milne, Helen Temperton, Hiran Thabrew, Nicholas Bowden
Population-level administrative data provides a cost-effective means of monitoring health outcomes and service needs of clinical populations. This study aimed to present a method for case identification of non-traumatic brain injury in population-level data and to examine the association with sociodemographic factors. An estimated resident population of youth aged 0–24 years was constructed using population-level
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Clopidogrel with indobufen or aspirin in minor ischemic stroke or high-risk transient ischemic attack: a randomized controlled clinical study BMC Neurol. (IF 2.6) Pub Date : 2024-03-01 Xudong Liu, Xuxian Lv, Yanfang Peng, Jianing Wang, Junjie Lei, Chaogang Tang, Shijian Luo, Weihua Mai, Yiming Cai, Qian Fan, Chenhao Liu, Lei Zhang
Ischemic stroke and transient ischemic attack (TIA) are the most prevalent cerebrovascular diseases. The conventional antiplatelet drugs are associated with an inherent bleeding risk, while indobufen is a new antiplatelet drug and has the similar mechanism of antiplatelet aggregation as aspirin with more safety profile. However, there have been no studies evaluating the combination therapy of indobufen
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Butyrylcholinesterase activity in patients with postoperative delirium after cardiothoracic surgery or percutaneous valve replacement- an observational interdisciplinary cohort study BMC Neurol. (IF 2.6) Pub Date : 2024-03-01 Konstantin Schlake, Johannes Teller, Lukas Hinken, Hans Laser, Ralf Lichtinghagen, Andreas Schäfer, Christine Fegbeutel, Karin Weissenborn, Carolin Jung, Hans Worthmann, Maria Magdalena Gabriel
Postoperative delirium is a frequent and severe complication after cardiac surgery. Activity of butyrylcholinesterase (BChE) has been discussed controversially regarding a possible role in its development. This study aimed to investigate the relevance of BChE activity as a biomarker for postoperative delirium after cardiac surgery or percutaneous valve replacement. A total of 237 patients who received
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Targeting the foramen ovale is the point of percutaneous balloon compression? Comment on: Robot-assisted percutaneous balloon compression for trigeminal neuralgia-preliminary experiences BMC Neurol. (IF 2.6) Pub Date : 2024-02-27 Jun Zhong
The paper titled “Robot-assisted percutaneous balloon compression for trigeminal neuralgia- preliminary experiences” published in your journal [Li N, et al. BMC Neurol 2023: 22;23(1):163] [1] has prompted me to offer commentary on the integration of modern navigation systems in the process of percutaneous balloon compression (PBC). The use of robot-assisted techniques may improve cannula engagement
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The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults BMC Neurol. (IF 2.6) Pub Date : 2024-02-27 Aravind Lathika Rajendrakumar, Konstantin G. Arbeev, Olivia Bagley, Anatoliy I. Yashin, Svetlana Ukraintseva
Functional decline associated with dementia, including in Alzheimer’s disease (AD), is not uniform across individuals, and respective heterogeneity is not yet fully explained. Such heterogeneity may in part be related to genetic variability among individuals. In this study, we investigated whether the SNP rs6859 in nectin cell adhesion molecule 2 (NECTIN2) gene (a major risk factor for AD) influences
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First report of a p.Cys484Tyr Notch3 mutation in a CADASIL patient with acute bilateral multiple subcortical infarcts—case report and brief review BMC Neurol. (IF 2.6) Pub Date : 2024-02-26 Weili Liu, Jie Zhang, Jian Li, Shuai Jia, Yanqiang Wang, Jianhong Geng, Yaozhen Wang
CADASIL(Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)is an inherited small vessel disease caused by mutations in NOTCH3 gene. Although NOTCH3 has numerous hotspots of gene mutations, mutations in exons 9 are rare. The p.C484T gene mutation type associated with it has not been reported in any relevant cases yet. Furthermore, CADASIL patients rarely present
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Serum levels of glucose, thyroid stimulating hormone, and free thyroxine in boys diagnosed with attention deficit hyperactivity disorder: a cross-sectional pilot study BMC Neurol. (IF 2.6) Pub Date : 2024-02-26 Tanja Lukovac, Olivera Aleksić Hil, Milka Popović, Tatjana Savić, Aleksandra M. Pavlović, Dragan Pavlović
Although attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, its aetiology remains unclear. We aimed to establish a relationship between ADHD diagnosis and serum levels of glucose, free thyroxine (FT4), and thyroid stimulating hormone (TSH) in primary school aged boys. In a cross-sectional study, we enrolled 133 participants aged 6.5–12.5 years, 67 of whom met DSM-5
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A clinical 3D pointing test differentiates spatial memory deficits in dementia and bilateral vestibular failure BMC Neurol. (IF 2.6) Pub Date : 2024-02-23 J. Gerb, T. Brandt, M. Dieterich
Deficits in spatial memory, orientation, and navigation are often neglected early signs of cognitive impairment or loss of vestibular function. Real-world navigation tests require complex setups. In contrast, simple pointing at targets in a three-dimensional environment is a basic sensorimotor ability which provides an alternative measure of spatial orientation and memory at bedside. The aim of this
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Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma BMC Neurol. (IF 2.6) Pub Date : 2024-02-21 Dongdong Zang, Zilong Dong, Yuecheng Liu, Qian Chen
Anaplastic ependymoma and H3K27M-mutant diffuse midline glioma are two common subtypes of brain tumors with poor long-term prognosis. The present study analyzed and compared the differences in cell types between two tumors by single-cell RNA sequencing (scRNA-seq) technology. ScRNA-seq was performed to profile cells from cancer tissue from anaplastic ependymoma patient and H3K27M-mutant diffuse midline
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The role of ataluren in the treatment of ambulatory and non-ambulatory children with nonsense mutation duchenne muscular dystrophy - a consensus derived using a modified Delphi methodology in Eastern Europe, Greece, Israel and Sweden BMC Neurol. (IF 2.6) Pub Date : 2024-02-21 Tanja Golli, Lenka Juříková, Thomas Sejersen, Craig Dixon
This paper details the results of an evaluation of the level of consensus amongst clinicians on the use of ataluren in both ambulatory and non-ambulatory patients with nonsense mutation Duchenne muscular dystrophy (nmDMD). The consensus was derived using a modified Delphi methodology that involved an exploration phase and then an evaluation phase. The exploration phase involved 90-minute virtual 1:1
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Risk factors for post-cerebral infarction cognitive dysfunction in older adults: a retrospective study BMC Neurol. (IF 2.6) Pub Date : 2024-02-20 Fanyuan Ma, Qian Zhang, Jinke Li, Liping Wu, Hua Zhang
Our research aims to elucidate the significance of type 2 diabetes (T2D) and provides an insight into a novel risk model for post-cerebral infarction cognitive dysfunction (PCICD). Our study recruited inpatients hospitalized with cerebral infarction in Xijing hospital, who underwent cognitive assessment of Mini-Mental State Examination (MMSE) from January 2010 to December 2021. Cognitive status was
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Leading determinants of incident dementia among individuals with and without the apolipoprotein E ε4 genotype: a retrospective cohort study BMC Neurol. (IF 2.6) Pub Date : 2024-02-20 Siting Ye, Eddy Roccati, Wei Wang, Zhuoting Zhu, Katerina Kiburg, Yu Huang, Xueli Zhang, Xiayin Zhang, Jiahao Liu, Shulin Tang, Yijun Hu, Zongyuan Ge, Honghua Yu, Mingguang He, Xianwen Shang
Little is known regarding the leading risk factors for dementia/Alzheimer’s disease (AD) in individuals with and without APOE4. The identification of key risk factors for dementia/Alzheimer’s disease (AD) in individuals with and without the APOE4 gene is of significant importance in global health. Our analysis included 110,354 APOE4 carriers and 220,708 age- and sex-matched controls aged 40–73 years
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Differential expression of Semaphorin-7A /CD163-positive macrophages in large artery and cardiogenic stroke BMC Neurol. (IF 2.6) Pub Date : 2024-02-19 Yi Jiang, Zhichao Sun, Zhonglin Ge, Zhonghai Tao, Mengqian Liu, Wen Zhong, Nan Dong, Lei Xu, Hui Wang, Yiwen Xu, Xiaozhu Shen
Identification of the causes of stroke of undetermined etiology, specifically cardioembolism (CE) and non-CE causes, can inform treatment planning and prognosis prediction. The objective of this study was to analyze the disparities in thrombus composition, particularly Semaphorin-7A (Sema7A) and CD163, between patients diagnosed with large-artery atherosclerosis (LAA) and those with CE, and to investigate
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A case report: new-onset nummular headache after stenting of the middle cerebral artery BMC Neurol. (IF 2.6) Pub Date : 2024-02-19 Yuanyuan Liu, Xuehong Chu, Xiao Dong, Erlan Yu, Xiaole Jia, Chuanjie Wu, Xunming Ji
Nummular headache (NH) is categorized as a primary headache in the International Classification of Headache Disorders, Third edition (ICHD-3) diagnostic criteria, but there are secondary etiologies as well. We present a case of secondary NH that associated with vascular lesion. We report on a 40-year-old man with a medical history of symptomatic intracranial arterial stenosis who developed a headache
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Study on prognosis of acutely ruptured intracranial aneurysms (SPARTA): a protocol for a multicentre prospective cohort study BMC Neurol. (IF 2.6) Pub Date : 2024-02-17 Alexander L. Hamming, Jeroen T.J.M. van Dijck, Tjitske Visser, Martine Baarse, Dagmar Verbaan, Hanna Schenck, Roel H.L. Haeren, Rahman Fakhry, Ruben Dammers, René Aquarius, Jeroen H.D. Boogaarts, Wilco C. Peul, Wouter A. Moojen
Ruptured intracranial aneurysms resulting in subarachnoid haemorrhage can be treated by open surgical or endovascular treatment. Despite multiple previous studies, uncertainties on the optimal treatment practice still exists. The resulting treatment variation may result in a variable, potentially worse, patient outcome. To better inform future treatment strategies, this study aims to identify the effectiveness
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Risdiplam therapy in adults with 5q-SMA: observational study on motor function and treatment satisfaction BMC Neurol. (IF 2.6) Pub Date : 2024-02-17 Bogdan Bjelica, Camilla Wohnrade, Iraima Cespedes, Alma Osmanovic, Olivia Schreiber-Katz, Susanne Petri
We aimed to describe the experience of a single neuromuscular center in Germany in treating adult spinal muscular atrophy (SMA) patients with risdiplam and to analyze motor function and treatment satisfaction during a follow-up period up to 20 months. Fourteen patients with type 2 or 3 SMA (seven with SMA type 2, six with SMA type 3; age range: 18–51) were included. The Revised Upper Limb Module (RULM)
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Pain assessment tools in adults with communication disorders: systematic review and meta-analysis BMC Neurol. (IF 2.6) Pub Date : 2024-02-17 Álvaro Sabater-Gárriz, Jesús Molina-Mula, Pedro Montoya, Inmaculada Riquelme
Verbal communication is the "gold standard" for assessing pain. Consequently, individuals with communication disorders are particularly vulnerable to incomplete pain management. This review aims at identifying the current pain assessment instruments for adult patients with communication disorders. A systematic review with meta-analysis was conducted on PubMed, PEDRO, EBSCOhost, VHL and Cochrane databases
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Personalized decision-making for aneurysm treatment of aneurysmal subarachnoid hemorrhage: development and validation of a clinical prediction tool BMC Neurol. (IF 2.6) Pub Date : 2024-02-15 Jordi de Winkel, Bob Roozenbeek, Simone A. Dijkland, Ruben Dammers, Pieter-Jan van Doormaal, Mathieu van der Jagt, David van Klaveren, Diederik W. J. Dippel, Hester F. Lingsma
In patients with aneurysmal subarachnoid hemorrhage suitable for endovascular coiling and neurosurgical clip-reconstruction, the aneurysm treatment decision-making process could be improved by considering heterogeneity of treatment effect and durability of treatment. We aimed to develop and validate a tool to predict individualized treatment benefit of endovascular coiling compared to neurosurgical
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Geographic differences in pharmacotherapy patterns and outcomes of acute ischemic stroke in China BMC Neurol. (IF 2.6) Pub Date : 2024-02-15 Ying Li, Qianhua Ou, Yuxuan Lu, Zhiyuan Shen, Jieyu Li, Zhuangzhuang Zhang, Liwen Tai, Guozhong Li, Huisheng Chen, Guiru Zhang, Lei Zhang, Xuwen Sun, Jinhua Qiu, Yan Wei, Sainan Zhu, Zhaoxia Wang, Weiping Sun, Yining Huang
Vast economic and healthcare status discrepancies exist among regions in China, contributing to different treatment patterns. This study was aimed to investigate the current status of pharmacotherapy for acute ischemic stroke (AIS) and outcomes in China and explore the geographic variation in stroke care. This study was a multicenter prospective registry study, which collected the data of patients
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Early blood pressure lowering therapy is associated with good functional outcome in patients with intracerebral hemorrhage BMC Neurol. (IF 2.6) Pub Date : 2024-02-14 Xinni Lv, Xueyun Liu, Zicheng Hu, Lan Deng, Zuoqiao Li, Jing Cheng, Mingjun Pu, Qi Li
The implementation of a care bundle might improve functional outcome for patients with intracerebral hemorrhage (ICH). However, the impact of anti-hypertensive treatment on ICH outcomes remains uncertain. Our objective is to examine whether early blood pressure (BP) lowering therapy within first 12 h is associated with good outcome in ICH patients. We included acute ICH patients who had baseline computed
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T1 hypointense brain lesions in NMOSD and its relevance with disability: a single institution cross-sectional study BMC Neurol. (IF 2.6) Pub Date : 2024-02-12 Mohamad Ghazanfari Hashemi, Vahid Talebi, Naghmeh Abbasi Kasbi, Mehrshad Abbasi, Nasrin Asgari, Mohammad Ali Sahraian
T1 hypointense lesions are considered a surrogate marker of tissue destruction. Although there is a shortage of evidence about T1 hypointense brain lesions, black holes, in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD), the clinical significance of these lesions is not well determined. The impact of T1 hypointense brain lesions on the clinical status and the disability level of patients
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Systematic review of the patient burden of generalised myasthenia gravis in Europe, the Middle East, and Africa BMC Neurol. (IF 2.6) Pub Date : 2024-02-10 J McCallion, A Borsi, W Noel, J Lee, W Karmous, S Sattler, GM Boggia, EJ Hardy, CR Mitchell, SA Mitchell, Nils Erik Gilhus
Myasthenia gravis (MG) is a rare autoimmune disease characterised by muscle weakness, and progression from ocular (oMG) to generalised (gMG) symptoms results in a substantial negative impact on quality of life (QoL). This systematic review aimed to provide an overview of the patient burden experienced by people living with gMG. Electronic database searches (conducted March 2022), supplemented by interrogation
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Cognitive function and quantitative electroencephalogram analysis in subjects recovered from COVID-19 infection BMC Neurol. (IF 2.6) Pub Date : 2024-02-10 Manal M. Gaber, Hanan Hosny, Mona Hussein, Mona A. Ashmawy, Rehab Magdy
Objective assessment of post-COVID-19 cognitive dysfunction is highly warranted. This study aimed to evaluate the cognitive dysfunction of COVID-19 survivors with cognitive complaints, both clinically and neurophysiologically, using Quantitative Electroencephalogram (QEEG). This case–control study was conducted on 50 recovered subjects from COVID-19 infection with cognitive complaints and 50 age, sex
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Preliminary findings on diagnostic performance of computed tomography perfusion images for intracranial arterial stenosis: a retrospective study BMC Neurol. (IF 2.6) Pub Date : 2024-02-09 Hui Liu, Dan Wu, Zhi-bin Chen, Qian Xiao, Ji-wei Cheng, Xiao-yan Xie, Dong-xiao Qu, Jie Tao, Wei-zhong Wang, Yi-feng Peng, Guo-yi Li, Ying-feng Weng
Computed tomographic perfusion (CTP) can play an auxiliary role in the selection of patients with acute ischemic stroke for endovascular treatment. However, data on CTP in non-stroke patients with intracranial arterial stenosis are scarce. We aimed to investigate images in patients with asymptomatic intracranial arterial stenosis to determine the detection accuracy and interpretation time of large/medium-artery
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Arterial transit artifact as a short-term prognostic indicator in acute ischemic stroke BMC Neurol. (IF 2.6) Pub Date : 2024-02-09 Min Shan, Kaili Liu, Yi Ma, Qingxiu Zhang, Wenwei Yun, Min Zhang
Arterial transit artifact (ATA) observed on arterial spin labeling (ASL) was recently suggested to be associated with improved functional outcomes following acute ischemic stroke (AIS). AIS is a heterogeneous disease with diverse pathogenic mechanisms depending on the stroke subtype. This study aimed to investigate the association between ATA and 3-month functional outcomes in AIS patients according
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The prevalence and risk factors for phantom limb pain: a cross-sectional survey BMC Neurol. (IF 2.6) Pub Date : 2024-02-06 Katleho Limakatso, F. Ndhlovu, A. Usenbo, S. Rayamajhi, C. Kloppers, R. Parker
We previously performed a systematic review and meta-analysis which revealed a Phantom Limb Pain (PLP) prevalence estimate of 64% [95% CI: 60.01–68.1]. The prevalence estimates varied significantly between developed and developing countries. Remarkably, there is limited evidence on the prevalence of PLP and associated risk factors in African populations. Adults who had undergone limb amputations between
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The clinical and neuroimaging differences between vascular parkinsonism and Parkinson’s disease: a case-control study BMC Neurol. (IF 2.6) Pub Date : 2024-02-06 Peter George, Tamer Roushdy, Mai Fathy, Eman Hamid, Yosra Abdelzaher Ibrahim, Mahmoud El-Belkimy, Mohamed Ossama Abdulghani, Ali Shalash
Parkinson’s disease (PD) and vascular parkinsonism (VaP) have highly overlapping phenotypes, and different prognosis. This study comprehensively investigated the clinical, brain MRI and transcranial sonography differences between VaP and PD. Forty-eight patients with PD, 27 patients with VaP, and 29 healthy controls were compared. All patients were assessed using the MDS-UPDRS, Berg Balance Scale (BBS)
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Efficacy and safety of hyperbaric oxygen therapy in acute ischaemic stroke: a systematic review and meta-analysis BMC Neurol. (IF 2.6) Pub Date : 2024-02-03 Xuezheng Li, Lijun Lu, Yu Min, Xuefeng Fu, Kaifeng Guo, Wen Yang, Hao Li, Haoming Xu, Hua Guo, Zhen Huang
This study aims to evaluate the efficacy and safety of adjunctive hyperbaric oxygen therapy (HBOT) in acute ischaemic stroke (AIS) based on existing evidence. We conducted a comprehensive search through April 15, 2023, of seven major databases for randomized controlled trials (RCTs) comparing adjunctive hyperbaric HBOT with non-HBOT (no HBOT or sham HBOT) treatments for AIS. Data extraction and assessment
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Persistent trigeminal artery in a patient with moyamoya disease:a case report and literature review BMC Neurol. (IF 2.6) Pub Date : 2024-02-02 Tao Sun, Lixin Huang, Jun Sun, Zhimin Wu, Chuan Chen, Hui Wang
Persistent trigeminal artery (PTA) is a rare anastomosis between internal carotid artery (ICA) and basilar artery. In rare conditions, the PTA could be combined with others cerebrovascular anomalies, moyamoya disease (MMD) is one of them. Here, we reported one rare case of MMD associated with PTA, the patient admitted to our department for severe dizziness and headache, imaging examination suggested
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The effectiveness of physiotherapy for patients with isolated cervical dystonia: an updated systematic review and meta-analysis BMC Neurol. (IF 2.6) Pub Date : 2024-02-01 Shimelis Girma Kassaye, Willem De Hertogh, David Crosiers, Esayas Kebede Gudina, Joke De Pauw
Cervical dystonia is a movement disorder typically characterized by a patterned and twisting movement of sustained or intermittent muscle contractions. Recently, new clinical trials are emerging, highlighting the potential benefit of physiotherapy (PT) on disease outcomes. Thus, the objective of this review is to update the effectiveness of PT on cervical dystonia disease outcomes and subsequently
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Theta burst stimulation: what role does it play in stroke rehabilitation? A systematic review of the existing evidence BMC Neurol. (IF 2.6) Pub Date : 2024-02-01 Tingting Jiang, Xiupan Wei, Mingzhu Wang, Jiang Xu, Nan Xia, Min Lu
Various post-stroke dysfunctions often result in poor long-term outcomes for stroke survivors, but the effect of conventional treatments is limited. In recent years, lots of studies have confirmed the effect of repetitive transcranial magnetic stimulation (rTMS) in stroke rehabilitation. As a new pattern of rTMS, theta burst stimulation (TBS) was proved recently to yield more pronounced and long-lasting
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Exploring humanistic burden of fatigue in adults with multiple sclerosis: an analysis of US National Health and Wellness Survey data BMC Neurol. (IF 2.6) Pub Date : 2024-02-01 Hoa H. Le, Jennifer Ken-Opurum, Anne LaPrade, Martine C. Maculaitis, John J. Sheehan
This retrospective study examined the humanistic burden of fatigue in patients with relapsing-remitting multiple sclerosis (RRMS), compared with adults without MS, using data from the 2017 and 2019 US National Health and Wellness Survey. The 5-item Modified Fatigue Impact Scale (MFIS-5) was used to assess level of fatigue (MFIS-5 score <15: low fatigue [LF]; MFIS-5 score ≥15: high fatigue [HF]) in
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Feasibility of early radial artery occlusion recanalization and reuse through transradial access for neuroendovascular procedures BMC Neurol. (IF 2.6) Pub Date : 2024-01-31 Ranze Cai, Yingchuang Jiang, Jian Wu, Qiuping Li, Biao Qi
Radial artery occlusion (RAO) remains a significant limitation of neuroendovascular procedures peformed through transradial access (TRA) when radial artery needs to be reused. Instances of early RAO recanalization to successfully complete neuroendovascular procedures have been rarely documented. Documents and imaging data were extracted retrospectively for all patients who underwent TRA diagnostic
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Effect of exercise on sleep quality in Parkinson’s disease: a mini review BMC Neurol. (IF 2.6) Pub Date : 2024-01-30 M. Abdullah Shafiq, Jyotpal Singh, Zain A. Khan, J. Patrick Neary, Holly A. Bardutz
The growing incidence of Parkinson’s Disease (PD) is a major burden on the healthcare system. PD is caused by the degeneration of dopaminergic neurons and is known for its effects on motor function and sleep. Sleep is vital for maintaining proper homeostasis and clearing the brain of metabolic waste. Adequate time spent in each sleep stage can help maintain homeostatic function; however, patients with
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Efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke: a meta-analysis BMC Neurol. (IF 2.6) Pub Date : 2024-01-29 Huanjia Huang, Jian Zhang, Jinmei Lin, Shengliang Shi
This meta-analysis and systematic review were conducted to comprehensively evaluate the efficacy and safety of mesenchymal stem cells in patients with acute ischemic stroke. We conducted a manual search of electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, with a search deadline set for February 1, 2023. Data analysis was performed using Stata version 15.0. A
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Exploring the link between self-management of migraine and emotional wellbeing: a cross-sectional study of community-dwelling migraine sufferers BMC Neurol. (IF 2.6) Pub Date : 2024-01-27 Nicola Filzmoser, Iman Webber, Gabriele Kerr, Aos Alaa, Marie Iine El Asmar, Manisha Karki, Eva Riboli-Sasco, Austen El-Osta
Globally, an estimated 14% of adults live with migraine disease which impacts their physical, emotional and social wellbeing. To target the disease comprehensively, research recommends a multidisciplinary approach to migraine management. Yet, at present, migraine management primarily centers around pharmaceutical treatments. The aim of this study was to investigate the extent to which emotional awareness
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Impact of frailty, biomarkers and basic biochemical parameters on outcomes of comatose patients in status epilepticus: a single-center prospective pilot study BMC Neurol. (IF 2.6) Pub Date : 2024-01-26 Zdenek Krejzar, David Sila, Petr Waldauf, Eduard Kuriscak, Petr Mokrejs, Vera Spatenkova
Status epilepticus (SE) is a severe acute condition in neurocritical care with high mortality. Searching for risk factors affecting the prognosis in SE remains a significant issue. The primary study’s aim was to test the predictive values of the Clinical Frailty Scale (CFS) and the Modified 11-item Frailty Index (mFI-11), the biomarkers and basic biochemical parameters collected at ICU on the Glasgow
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Feasibility of a clinical-radiomics combined model to predict the occurrence of stroke-associated pneumonia BMC Neurol. (IF 2.6) Pub Date : 2024-01-25 Haowen Luo, Jingyi Li, Yongsen Chen, Bin Wu, Jianmo Liu, Mengqi Han, Yifan Wu, Weijie Jia, Pengfei Yu, Rui Cheng, Xiaoman Wang, Jingyao Ke, Hongfei Xian, Jianglong Tu, Yingping Yi
To explore the predictive value of radiomics in predicting stroke-associated pneumonia (SAP) in acute ischemic stroke (AIS) patients and construct a prediction model based on clinical features and DWI-MRI radiomics features. Univariate and multivariate logistic regression analyses were used to identify the independent clinical predictors for SAP. Pearson correlation analysis and the least absolute
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A case of Wilson’s disease combined with intracranial lipoma and dysplasia of the corpus callosum with review of the literature BMC Neurol. (IF 2.6) Pub Date : 2024-01-25 Liangjie Zhang, Ling Zhu, Chunling Ci, Wenlong Ai, Yu Wang, Xun Wang
Wilson’s disease (WD) is an inherited disorder of copper metabolism. Agenesis of the corpus callosum is the complete or partial absence of the major united fiber bundles connecting the cerebral hemispheres. Intracranial lipoma is an adipose tissue tumor resulting from an abnormal embryonic development of the central nervous system. The simultaneous occurrence of these three disorders is rare and has
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Spinal adhesive arachnoiditis in an adult patient with spinal muscular atrophy type 3 treated with intrathecal therapy BMC Neurol. (IF 2.6) Pub Date : 2024-01-24 Jakub Ubysz, Magdalena Koszewicz, Joanna Bladowska, Slawomir Budrewicz
Spinal adhesive arachnoiditis is a chronic inflammatory process of the leptomeninges and intrathecal neural elements. The possible causes of arachnoiditis are: infections, injuries of spinal cord, surgical procedures and intrathecal administration of therapeutic substances or contrast. We present a case of 56-old woman with spinal muscular atrophy type 3 who developed a severe back pain in the lumbosacral
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Acute ischemic stroke in Tsutsugamushi: understanding the underlying mechanisms and risk factors BMC Neurol. (IF 2.6) Pub Date : 2024-01-24 Dain Kim, Yeon Hee Cho, Jeong Bin Bong, Young Seo Kim, Byoung-Soo Shin, Hyun Goo Kang
Tsutsugamushi (scrub typhus) is an acute infectious febrile disease common in the Asia-Pacific region. Common symptoms of tsutsugamushi include lymphadenopathy, fever, and myalgia, and it rarely causes acute ischemic stroke (AIS). However, we hypothesized that tsutsugamushi infection could trigger AIS. We retrospectively examined patients diagnosed with AIS within 2 weeks of tsutsugamushi diagnosis
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Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study BMC Neurol. (IF 2.6) Pub Date : 2024-01-24 Nega Dagnew Baye, Fikadie Dagnew Baye, Assefa Agegnehu Teshome, Atalo Agimas Ayenew, Anmut Tilahun Mulu, Endeshaw Chekol Abebe, Zelalem Tilahun Muche
Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which may result in worse outcomes. It is also a well-recognized risk factor for the development of late post-traumatic seizure and epilepsy. This study was aimed to assess
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Updating the study protocol: Insight 46 – a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development – phases 2 and 3 BMC Neurol. (IF 2.6) Pub Date : 2024-01-23 Heidi Murray-Smith, Suzie Barker, Frederik Barkhof, Josephine Barnes, Thomas M. Brown, Gabriella Captur, Molly R.E.Cartlidge, David M. Cash, William Coath, Daniel Davis, John C. Dickson, James Groves, Alun D. Hughes, Sarah-Naomi James, Ashvini Keshavan, Sarah E. Keuss, Josh King-Robson, Kirsty Lu, Ian B. Malone, Jennifer M. Nicholas, Alicja Rapala, Catherine J. Scott, Rebecca Street, Carole H. Sudre
Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person’s risk for cognitive decline later in life. Furthermore, the pathological processes leading to dementia are not fully understood. The main goals of Insight 46—a multi-phase longitudinal observational study—are to collect detailed cognitive, neurological