-
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection Pain Res. Manag. (IF 2.9) Pub Date : 2024-3-18 Chan Hong Park, Sang Ho Lee
Background. Lumbar spinal stenosis (LSS) causes low back pain, leg pain, numbness in the leg, and neurogenic intermittent claudication. Epidural steroid injection (ESI) has been used for treating spinal stenosis symptoms. We hypothesized that dural pulsation was variable for lumbar spinal stenosis. In cases of the presence of dural pulsation, the pain relief after the ESI was better than in the absence
-
NGF Signaling Exacerbates KOA Peripheral Hyperalgesia via the Increased TRPV1-Labeled Synovial Sensory Innervation in KOA Rats Pain Res. Manag. (IF 2.9) Pub Date : 2024-2-19 Zixiu Liu, Mingchao Li, Li Zhang, Xiaoqing Shi, Taiyang Liao, Lishi Jie, Likai Yu, Peimin Wang
Objectives. Knee osteoarthritis (KOA) pain is caused by nociceptors, which are actually sensory nerve fiber endings that can detect stimuli to produce and transmit pain signals, and high levels of NGF in synovial tissue led to peripheral hyperalgesia in KOA. The purpose of this study is to investigate how sensory nerve fibers respond to the NGF/TrKA signal pathway and mediate the peripheral hyperalgesia
-
Neuropathic Pain Medication and Antidepressant Use after Disability Pension in Patients with Spinal Cord Stimulation for Persistent Spinal Pain Syndrome Pain Res. Manag. (IF 2.9) Pub Date : 2024-1-31 Hanna Kaijankoski, Mette Nissen, Tiina-Mari Ikäheimo, Mikael von und zu Fraunberg, Olavi Airaksinen, Jukka Huttunen
Background. Treatment of persistent spinal pain syndrome (PSPS) is challenging. Chronic pain associated with PSPS can lead to an impaired ability to work. Objective. To obtain information on whether receiving a disability pension (DP) affects pain and pain treatments in retiring working-age PSPS patients. Neuropathic pain medication and antidepressant use were considered as an indicator of neuropathic
-
How Do We Treat Children with Anterior Cutaneous Nerve Entrapment Syndrome and Is the Biopsychosocial Model Also Being Applied? A Scoping Review Pain Res. Manag. (IF 2.9) Pub Date : 2024-1-29 Anke P. C. Top, Thomas G. de Leeuw, Wichor M. Bramer, Bernadette C. M. de Mol, Frank J. P. M. Huygen, Maaike Dirckx
Background. Evidence-based guidelines for managing anterior cutaneous nerve entrapment syndrome (ACNES) in children are absent. The primary aim of this review was to scrutinize the evidence supporting currently used treatment interventions. In accordance with the World Health Organization (WHO) guidelines for managing chronic pain in children, these patients and their families and caregivers should
-
Relationship between Fear-Avoidance Beliefs and Reaction Time Changes Prior to and following Exercise-Induced Muscle Fatigue in Chronic Low Back Pain Pain Res. Manag. (IF 2.9) Pub Date : 2024-1-27 Wenwu Xiao, Huaichun Yang, Zengming Hao, Menglin Li, Mengchu Zhao, Siyun Zhang, Guifang Zhang, Haian Mao, Chuhuai Wang
Background. Reaction time is a reliable indicator of the velocity and efficiency of neuromuscular control and may be associated with fear-avoidance beliefs. However, the effect of exercise-induced muscle fatigue on reaction time in chronic low back pain (cLBP) and its relationship with fear-avoidance beliefs remains poorly understood. Objectives. This study aimed to reveal the relationship between
-
A Comparison of the Effects of Acupressure and Music on Venipuncture Pain Intensity in Children: A Randomized Controlled Clinical Trial Pain Res. Manag. (IF 2.9) Pub Date : 2024-1-18 Faezeh Daihimfar, Hassan Babamohamadi, Raheb Ghorbani
Pain from injections is common in children of all ages, and more than 90% of hospitalized children experience invasive and painful procedures such as venipuncture. In light of the complications associated with pain relief medications, nonpharmacological and complementary medicine approaches have gained attention. This study aims to compare the effects of acupressure and music on venipuncture pain intensity
-
Quadratus Lumborum Block versus Fascia Iliaca Compartment Block for Acetabular Fracture Surgery by Stoppa Method: A Double-Blind, Randomized, Noninferiority Trial Pain Res. Manag. (IF 2.9) Pub Date : 2024-1-5 Alireza Mirkheshti, Morteza Hashemian, Dariush Abtahi, Sara Shayegh, Alireza Manafi-Rasi, Shahram Sayadi, Elham Memary, Nazli Karami, Baharak Rostamian, Alireza Shakeri
Background. Acetabular fracture surgeries are frequently accompanied by protracted and severe perioperative pain, and there is no consensus on optimal pain relief management. Aim. This study aimed at comparing the analgesic efficacy of fascia iliaca compartment block (FICB) and quadratus lumborum block (QLB) in patients with acetabular fractures undergoing surgery using the Stoppa method. Methods.
-
Role of TNF-α in the Pathogenesis of Migraine Pain Res. Manag. (IF 2.9) Pub Date : 2024-1-3 Amrit Sudershan, Srishty Sudershan, Isha Sharma, Hardeep Kumar, Rakesh K. Panjaliya, Parvinder Kumar
Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range
-
Assessment of Analgesic Efficacy of Bilateral Lumbar Erector Spinae Plane Block for Postoperative Pain following Lumbar Laminectomy: A Single-Blind, Randomized Clinical Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-12-28 Seyed Amirreza Akhlagh, Arash Farbood, Mahsa Tahvili, Afshin Amini, Keyvan Eghbal, Naeimehossadat Asmarian, Mahsa Banifatemi, Seyed Ali Hosseini
Background. The erector spinae plane (ESP) block is a novel approach to minimizing postoperative pain. We investigated the efficacy and side effects of the ultrasonography-guided bilateral ESP block in reducing pain in the first 24 hours after lumbar laminectomy. Materials and Methods. We conducted a single-blind (statistical analyst and those responsible for recording patient information postoperation
-
Perioperative Nerve Blockade Reduces Acute Postoperative Pain after Orthognathic Surgery Pain Res. Manag. (IF 2.9) Pub Date : 2023-12-19 Yuka Oono, Saori Takagi, Lars Arendt-Nielsen, Hikaru Kohase
Background. The role of perioperative pain management is not only to reduce acute postoperative pain (POP) but also to prevent chronic POP. It would be important to know the usefulness of nerve blockade for perioperative management. However, it has not been extensively studied in orofacial surgery. The objective of the study was to investigate whether perioperative nerve blockade reduces acute POP
-
Coping Strategies with Genito-Pelvic Pain/Penetration Disorder: A Qualitative Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-12-16 Mojdeh Banaei, Vahid Mehrnoush, Nasibeh Roozbeh, Nourossadat Kariman
Background. Genital/pelvic pain penetration disorder (GPPPD) decreased mental and physical functioning, reduced quality of life, and reduced feelings of inadequacy and worthlessness, all of which impair the ability of women with GPPPD to enjoy sex. This qualitative study was conducted to identify which factors can reduce sexual stress and help Iranian women cope with GPPPD. Methods. This qualitative
-
Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation Pain Res. Manag. (IF 2.9) Pub Date : 2023-11-24 Dong-Dong Guo, Hai-Yan Huang, Hai-E. Liu, Kun Liu, Xing-Jing Luo
Background. Premature infants often undergo painful procedures and consequently experience repeated procedural neonatal pain. This can elicit hyperalgesia and cognitive impairment in adulthood. Treatments for neonatal pain are limited. Orientin is a flavonoid C-glycoside that has repeatedly been shown to have pharmacological effects in the past decades. The aim of this study was to systematically explore
-
The Impact and Correlation of Anxiety and Depression on Pressure Pain Threshold of Acupoints in Patients with Chronic Pelvic Inflammatory Disease Pain Res. Manag. (IF 2.9) Pub Date : 2023-11-21 Chenxi Liao, Yu Tan, Kai Wang, Xin Wen, Xiang Hu, Yefang Huang, Ying Li
Background. Chronic pelvic inflammatory disease (CPID) is a clinically common gynecological disease. Patients experience chronic pelvic pain and often accompany with emotional dysfunction. However, the impact and correlation of anxiety and depression on pain sensitization is not completely known. Objective. To explore the differences and correlations among anxiety, depression, and pressure pain threshold
-
Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome Pain Res. Manag. (IF 2.9) Pub Date : 2023-11-13 Yongfeng Lao, Zewen Li, Yanan Bai, Weijia Li, Jian Wang, Yanan Wang, Qingchao Li, Zhilong Dong
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases of the male urological system while the etiology and treatment of CP/CPPS remain a thorny issue. Cumulative research suggested a potentially important role of glial cells in CP/CPPS. This narrative review retrospected literature and grasped the research process about glial cells and CP/CPPS. Three types of
-
Can Ultrasound-Guided Continuous Paravertebral Block Reduce the Incidence of Chronic Postsurgical Pain in Patients with Thoracoscopic Lung Cancer Surgery? A Randomized Controlled Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-11-9 Wei Ran, Huan Luo, Zhiqiao Wang, Yonggang Hao, Ning Liang, Ping Li, Xia Yin, Jin Gao
Background. Thoracoscopic lung cancer surgery is accompanied by severe pain. Both continuous paravertebral block (CPVB) and continuous wound infiltration (CWI) are widely used for perioperative analgesia in thoracoscopic surgery. However, the effects of these different methods on chronic postsurgical pain (CPSP) are still unknown. Patients and Methods. This prospective randomized controlled trial assessed
-
Investigation for Factors Affecting Body Perception Disturbance in Patients with Low Back Pain by Mechanism-Based Classification of Pain: A Cross-Sectional Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-11-2 Yoshito Kurashima, Takumi Nakamura, Taishi Mukaiyama, Kenji Hasegawa, Hironobu Kuruma
Background. Central sensitization is a pathophysiological cause of chronic low back pain and is linked with psychosocial factors. The association between central sensitization (CS) and body perception disturbance is currently unclear, and no prior studies have investigated this relationship in patients with acute or subacute low back pain. The objective of this study was to investigate potential factors
-
Does a Positive Response to Transforaminal Epidural Steroid Injection Identify Patients Who Can Avoid Surgery for Two Years? Pain Res. Manag. (IF 2.9) Pub Date : 2023-10-14 Aki Fujiwara, Keisuke Watanabe, Hideki Shigematsu, Katsuhiro Kimoto, Mitsuru Ida, Yasuhito Tanaka, Masahiko Kawaguchi
Background. Transforaminal epidural steroid injection (TFESI) is widely used to manage lumbar radiculopathy. In clinical settings, patients often undergo repeated transforaminal epidural injections with or without steroid administration. Objectives. To examine whether a positive response to TFESI at the first month, can in clinical settings, identify patients with radiculopathy who can avoid surgery
-
Racial, Ethnic, and Language-Based Inequities in Inpatient Opioid Prescribing by Diagnosis from Internal Medicine Services, a Retrospective Cohort Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-9-21 Mihir Joshi, Priya A. Prasad, Colin C. Hubbard, Nicholas Iverson, Solmaz P. Manuel, Margaret C. Fang, Aksharananda Rambachan
Introduction. Opioid administration is extremely common in the inpatient setting, yet we do not know how the administration of opioids varies across different medical conditions and patient characteristics on internal medicine services. Our goal was to assess racial, ethnic, and language-based inequities in opioid prescribing practices for patients admitted to internal medicine services. Methods. We
-
The Relationship between Pain Catastrophizing and Cognitive Function in Chronic Musculoskeletal Pain: A Scoping Review Pain Res. Manag. (IF 2.9) Pub Date : 2023-9-9 Cory Alcon, Elizabeth Bergman, John Humphrey, Rupal M. Patel, Sharon Wang-Price
Objective. Chronic musculoskeletal pain (CMP) poses a considerable threat to physical, mental, and financial health worldwide. Beyond physical difficulties, CMP has a pronounced impact on pain behaviors and cognitive function. The purpose of this scoping review was to examine the relationship between pain catastrophizing (PC) and cognitive function in CMP, identify gaps in the literature, and provide
-
Clinical Application of Inferior Alveolar Nerve Block Device for Safe and Secure IANB by Any Operator Pain Res. Manag. (IF 2.9) Pub Date : 2023-9-8 Tomoyasu Noguchi, Kento Odaka, Ken-ichi Fukuda
The inferior alveolar nerve block (IANB) is an established technique with a success rate of 60–80%; however, large errors have been reported among operators. Some dentists do not prefer to use IANB because of the risk of complications. Nevertheless, it is a useful technique for pain control, and a secure IANB offers significant benefits to operators and patients. This case series study aimed to investigate
-
Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-8-31 Chanjuan Zhang, Xi Chen, Yi Yin, Dongfeng Xie, Jing Luo, Yinan Ai, Wenfeng Zhan, Hongjun Kan, Shuxian Zhang, Guihua Jiang, Xiquan Hu
Purpose. Deficits in voluntary activation of the core stabilizing muscles are consistently observed in patients with chronic low back pain (CLBP); however, the underlying neural mechanism remains unclear. This cross-sectional study aimed at testing the hypothesis that the impaired voluntary activation of core stabilizing muscles is associated with structural and functional alterations in the basal
-
Personality in Chronic Headache: A Systematic Review with Meta-Analysis. Pain Res. Manag. (IF 2.9) Pub Date : 2023-08-28 Sara Bottiroli,Alessia Renzi,Elena Ballante,Roberto De Icco,Grazia Sances,Annalisa Tanzilli,Tomaso Vecchi,Cristina Tassorelli,Federica Galli
Background Chronic headache (CH) is a condition that includes different subtypes of headaches and that can impair different life domains. Personality traits can play a relevant role both in the development and in coping with this medical condition. The first aim of the present study is to realize a systematic review of the personality traits associated with CH compared to healthy controls; the second
-
Outcomes of Pain Management Training for the Fourth- and Fifth-Year Medical Students Pain Res. Manag. (IF 2.9) Pub Date : 2023-8-25 Ayano Saeki, Yumiko Takao, Keiichiro Suzuki, Munetaka Hirose
Pain management is a major medical issue. However, current medical education in Japan is inadequate with regard to training students to properly assess patients with acute and chronic pain and plan their treatment. Therefore, starting in 2019, Hyogo Medical University established a multidisciplinary educational system to better train medical students to provide pain care. The course, called clinical
-
Effectiveness of Dry Needling in Improving Pain and Function in Comparison with Other Techniques in Patients with Chronic Neck Pain: A Systematic Review and Meta-Analysis Pain Res. Manag. (IF 2.9) Pub Date : 2023-8-23 Mar Hernández-Secorún, Hugo Abenia-Benedí, Sergio Borrella-Andrés, Isabel Marqués-García, María Orosia Lucha-López, Pablo Herrero, Isabel Iguacel, José Miguel Tricás-Moreno, César Hidalgo-García
The purpose of this systematic review and meta-analysis was to assess the short-, mid-, and long-term effectiveness of dry needling in improving pain and functional capacity of patients with chronic neck pain. Search strategy was performed on PubMed, Web of Science, Scopus, PEDro, and Cochrane Library Plus biomedical databases. The risk of bias was assessed using the RoB2 tool. Randomised controlled
-
Influence of Temperament on the Acceptance of Two Conscious Sedation Techniques in Toddlers Undergoing Dental Treatment: A Randomised Cross Over Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-8-22 Palak Janiani, Deepa Gurunathan, Sivakumar Nuvvula
Background. Pediatric dentists often find it challenging to handle pediatric patients due to their fear, unease, and anxiety toward dental procedures. To address this, sedation agents such as intranasal midazolam and nitrous oxide are commonly used as pharmacological behavior management methods. A child’s temperament affects their behavior in unfamiliar settings. Aim. To study the effect of child temperament
-
Application of Ketamine in Pain Management and the Underlying Mechanism Pain Res. Manag. (IF 2.9) Pub Date : 2023-8-16 Xiaofan Ma, Jia Yan, Hong Jiang
Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the few intravenous anesthetics with potent analgesic properties. As part of the effort to develop pain management, renewed interest has focused on the use of ketamine for the treatment of acute and chronic pain. Ketamine is commonly
-
The Efficacy of Manual Therapy and Pressure Biofeedback-Guided Deep Cervical Flexor Muscle Strength Training on Pain and Functional Limitations in Individuals with Cervicogenic Headaches: A Randomized Comparative Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-8-14 Shahnaz Hasan, Nasrin Bharti, Ahmad H. Alghadir, Amir Iqbal, Naiyer Shahzad, Abeer R. Ibrahim
Objective. This study aimed to compare the efficacy of manual therapy and pressure biofeedback-guided DCFM strength training on pain intensity and functional limitations in individuals with CGH. Trial Design. A double-blinded, two-arm parallel group randomized comparative design. Methods. After applying the eligibility criteria, sixty out of eighty-nine CGH patients were recruited from King Saud University
-
Knowledge and Attitudes regarding Temporomandibular Disorders among Postgraduate Dental Students and Practicing Dentists in Western China: A Questionnaire-Based Observational Investigation Pain Res. Manag. (IF 2.9) Pub Date : 2023-7-18 Xin Xiong, Chuqiao Xiao, Xueman Zhou, Xiaojing Li, Jun Wang, Yating Yi
Background. It is necessary for dental students and dentists to apply their temporomandibular disorders (TMDs)-related knowledge to clinical practice. The current study aimed to evaluate the knowledge and awareness of postgraduate dental students and practicing dentists regarding etiology, diagnosis, and treatment of TMD in western China and thus provide suggestions on TMD curricula design to get postgraduate
-
Artificial Intelligence for Automatic Pain Assessment: Research Methods and Perspectives Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-28 Marco Cascella, Daniela Schiavo, Arturo Cuomo, Alessandro Ottaiano, Francesco Perri, Renato Patrone, Sara Migliarelli, Elena Giovanna Bignami, Alessandro Vittori, Francesco Cutugno
Although proper pain evaluation is mandatory for establishing the appropriate therapy, self-reported pain level assessment has several limitations. Data-driven artificial intelligence (AI) methods can be employed for research on automatic pain assessment (APA). The goal is the development of objective, standardized, and generalizable instruments useful for pain assessment in different clinical contexts
-
Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-22 Bin Zou, Juan Du, Qiwen Xuan, Yajing Wang, Zixiao Wang, Wen Zhang, Lianghua Wang, Wei Gu
Background. High morbidity of nonspecific low back pain (NLBP) and large consumption of medical resources caused by it have become a heavy social burden. There are many factors inducing NLBP, among which the damage and atrophy of multifidus (MF) are most closely related to NLBP. Scraping therapy can have significant treatment effects on NLBP with fewer adverse reactions and less medical fund input
-
Can Baseline Characteristics Predict Successful Outcomes after Individual, Physiotherapist-Led Rehabilitation in Patients with Chronic Musculoskeletal Pain? Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-16 Elisabeth Bondesson, Anna Jöud, Marcelo Rivano Fischer, Anna Trulsson Schouenborg
Background. No strong and consistent variables to predict outcome after pain rehabilitation have been reported in patients with chronic musculoskeletal pain. The aim of the present study was to clarify if baseline variables could predict successful outcome after a unique, individualized, physiotherapist-led rehabilitation of nine sessions. Methods. In 274 individuals with severe chronic musculoskeletal
-
Erector Spinae Plane (ESP) Block for Postoperative Pain Management after Open Oncologic Abdominal Surgery Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-15 Michael Dubilet, Benjamin F. Gruenbaum, Michael Semyonov, Shlomo Yaron Ishay, Anton Osyntsov, Michael Friger, Alexander Geftler, Alexander Zlotnik, Evgeni Brotfain
Patients undergoing abdominal oncologic surgical procedures require particular surgical and anesthesiologic considerations. Traditional pain management, such as opiate treatment, continuous epidural analgesia, and non-opioid drugs, may have serious side effects in this patient population. We evaluated erector spinae plane (ESP) blocks for postoperative pain management following elective oncologic abdominal
-
Analgesic Effect of Passive Range-of-Motion Exercise on the Healthy Side for Pain after Total Knee Arthroplasty: A Prospective Randomized Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-14 Shuichi Eto, Motoki Sonohata, Yasuo Takei, Masaya Ueno, Norio Fukumori, Masaaki Mawatari
Background. Exercise can reduce the pain threshold momentarily and induce analgesia, which is called exercise-induced hypoalgesia (EIH). Exercise therapy for inducing EIH may be an effective treatment option for pain. We aimed at investigating whether continuous passive motion (CPM) on both healthy and affected sides could induce EIH and reduce pain in the operated knee in patients after unilateral
-
Analgesic Efficacy of Ketoprofen Transdermal Patch versus Ibuprofen Oral Tablet on Postendodontic Pain in Patients with Irreversible Pulpitis: A Randomized Clinical Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-7 Saeede Zadsirjan, Amirhossein Toghrolian, Nazanin Zargar
Background and Aim. Pain control is an integral part of dental treatment. The majority of patients complain of pain after endodontic procedures. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for postoperative pain management and are available in various forms. Ketoprofen transdermal patch (KTP) has been limitedly investigated for pain control after endodontic treatments. The
-
Association of COMT Val158Met Polymorphism with Fibromyalgia in Khartoum State, Sudan Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-3 Safaa Mamoun Abdelmageid, Faisal Mousa Alamir, Hassan Yousif Abdelrahman, Hind Mohamed Abushama
Fibromyalgia (FM) is a disorder characterized by chronic musculoskeletal pain, fatigue, and cognitive problems. Neurotransmitters, mainly catecholamines, appear to be involved in regulating the etiology of FM. Catechol-O-methyltransferase (COMT) is involved in catabolizing catecholamines such as norepinephrine. The most common variant studied in the COMT gene is the valine (Val) to methionine (Met)
-
Mechanism and Pharmacodynamic Substance Basis of Raw and Wine-Processed Evodia rutaecarpa on Smooth Muscle Cells of Dysmenorrhea Mice Pain Res. Manag. (IF 2.9) Pub Date : 2023-6-1 Yeqian Liu, Hong Li, Lei Chen, Hongxia Zhao, Jian Liu, Shan Gong, Danfeng Ma, Chunming Chen, Shuiqing Zeng, Hongping Long, Weiqiong Ren
Objectives. Evodia rutaecarpa (ER) is a well-known herbal Chinese medicine traditionally used for analgesia in dysmenorrhea, headaches, abdominal pain, etc. Notably, the analgesic effect of wine-processed Evodia rutaecarpa (PER) was more potent than that of raw ER. This research aimed to investigate the mechanism and pharmacodynamic substance basis of raw ER and PER on smooth muscle cells of dysmenorrhea
-
A Novel Scale to Assess Parental Satisfaction of Dental Local Anesthetic Techniques in Children: A Cross-Sectional Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-5-19 Muaaz Alkhouli, Zuhair Al-Nerabieah, Mayssoon Dashash
Background. Pain control is one of the most important aspects that can affect parental satisfaction of the dental care provided for children. Dental local anesthesia has the highest impact on pain sensation of the children. However, there is no scale in the literature to assess parental satisfaction of dental local anesthetic techniques. Objectives. This study was aimed to assess the parental satisfaction
-
Neuropathic Pain Was Associated with Central Sensitivity Syndrome in Patients with Preoperative Lumbar Spinal Stenosis Using the painDETECT and Central Sensitization Inventory Questionnaires: A Cross-Sectional Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-5-10 Rintaro Iwasaki, Takahiro Miki, Mizuki Miyazaki, Chifumi Kanetaka, Tetsuryu Mitsuyama, Kaiji Ota
Background. Lumbar spinal stenosis (LSS) patients have been reported to have neuropathic pain and central sensitivity syndrome (CSS). These associations have been reported in other diseases but are unknown in preoperative LSS patients. We aimed to investigate the association between neuropathic pain and CSS in preoperative LSS patients using the painDETECT and the Central Sensitization Inventory (CSI)
-
Efficacy of Spinal Cord Stimulation for Failed Back Surgery Syndrome in Elderly Patients: A Retrospective Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-5-9 Naoki Higashiyama, Shinya Tamura, Taku Sugawara
Objectives. Failed back surgery syndrome (FBSS) refers to a condition where symptoms such as low back pain, leg pain, and numbness persist or recur after lumbar surgery; it has been reported to occur in 10%–40% of patients who have undergone lumbar surgery. Spinal cord stimulation (SCS) has been reported useful for low back and leg pain due to FBSS. In this study, we studied the efficacy and safety
-
Clinical Effects and Safety of Auricular Acupressure as an Adjunct Therapy on Postoperative Pain among Patients with Hip Fracture: A Meta-Analysis Pain Res. Manag. (IF 2.9) Pub Date : 2023-4-24 Pin Li, Hongyun Chen, Xiuzhen Fu, Haili Zhou, Fan Lai
Objectives. To evaluate the short-term outcome of treatment by auricular acupressure (AA) on postoperative pain among hip fracture (HF) patients. Methods. A systematic search for randomized controlled trials on this topic was conducted through May 2022 by searching multiple English and Chinese databases. The methodological quality of the included trails was assessed by the Cochrane Handbook tool, and
-
Considerations on the Obstacles That Lead to Slow Recruitment in a Pain Management Clinical Trial: Experiences from the Belgian PELICAN (PrEgabalin Lidocaine Capsaicin Neuropathic Pain) Pragmatic Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-4-14 Guy H. Hans, Dima Almeshal, Lotte Vanlommel, Ella Roelant, Iris Verhaegen, Elke Smits, Koen Van Boxem, Robert Fontaine, The PELICAN Investigators Team
Background. A qualitative evaluation study of the prematurely terminated PrEgabalin Lidocaine Capsaicin Neuropathic Pain (PELICAN) study was performed. The PELICAN study aimed to examine pain management for localized neuropathic pain (LNP), as epidemiological figures have shown a high percentage of LNP patients in Belgium. The study compared systemic and topical medications according to pain relief
-
Perception of Heaviness Induced by Sensorimotor Incongruence Is Associated with Pain Prognosis: A Pilot Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-4-4 Soichiro Matsuda, Michihiro Osumi
Background. Patients with chronic musculoskeletal pain experience not only pain but also abnormal body perception. Such abnormal body perception has been reported to be caused by incongruence between motor intentions and sensory feedback (i.e., sensorimotor incongruence). However, the influence of abnormal body perception with sensorimotor incongruence on pain prognosis in musculoskeletal pain patients
-
Transition to Virtual Care Services during COVID-19 at Canadian Pain Clinics: Survey and Future Recommendations Pain Res. Manag. (IF 2.9) Pub Date : 2023-4-3 Victoria Borg Debono, Samuel Neumark, Norman Buckley, Ramesh Zacharias, Eleni Hapidou, Jennifer Anthonypillai, Susy Faria, Carrie-Lynn Meyer, Thomas Carter, Nadia Parker, Brenda Lau, Emmanuel Abreu, Scott Duggan, Etienne Bisson, Josie Pierre, Regina Visca, Patricia Poulin
Introduction. Due to the COVID-19 pandemic, healthcare centers quickly adapted services into virtual formats. Pain clinics in Canada play a vital role in helping people living with pain, and these clinics remained essential services for patients throughout the pandemic. This study aimed to (1) describe and compare the transition from in-person to virtual pain care services at Canadian pain clinics
-
Objective Evaluation of Chronic Low-Back Pain Using Serum Lipids: The Role of the Doctor-Patient Relationship Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-30 Tomáš Bruthans, Jana Vránová, Anna Yamamotová
Statistical data show that pain intensity in patients with low back pain is associated with a higher BMI, total serum cholesterol, and triacylglycerol levels. The objective of our study was to evaluate how these associations are dependent on the nature of the patient-doctor relationship. Eighty-nine patients hospitalized with chronic low-back pain (50 women, 39 men; average age: 64.5 ± 12.7 years)
-
The Effectiveness of Various Types of Electrical Stimulation of the Spinal Cord for Chronic Pain in Patients with Postherpetic Neuralgia: A Literature Review Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-24 Emil Isagulyan, Vasily Tkachenko, Denis Semenov, Svetlana Asriyants, Evgeny Dorokhov, Elizaveta Makashova, Karina Aslakhanova, Alexei Tomskiy
Introduction. Postherpetic neuralgia (PHN) is a severe condition that remains a challenge to treat. Spinal cord stimulation (SCS) is used in cases of insufficient efficacy of conservative treatment. However, in contrast to many other neuropathic pain syndromes, there is a huge problem in reaching long-term stable pain relief in patients with PHN using conventional tonic SCS. The objective of this article
-
A Survey of Neck Pain among Dentists of the Lebanese Community Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-23 Abed AlRaouf Kawtharani, Ali Msheik, Fadi Salman, Ali Haj Younes, Ammar Chemeisani
Background and Objectives. In the area of dentistry, musculoskeletal disorders (MSDs), particularly neck discomfort, are significant occupational health hazards. The purpose of this study was to ascertain how neck pain affected the capacity and productivity of dental practices. Additionally, it examined the advantages of preventive measures in lessening pain intensity and rated the degree of dentists’
-
Transversus Thoracis Muscle Plane Block in Paediatric Patients Who Underwent Minimally Invasive Closure of Transthoracic Ventricular Septal Defect: A Retrospective Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-21 Qiong Ling, Shuhua Zhao, Yongyong Shi, Xiangyu Li, Ping Li, Gaofeng Zhao, Qianqian Zhu
Objective. Minimally invasive closure of transthoracic ventricular septal defect (VSD) has been widely used in paediatric patients. This retrospective study aimed to explore the use of transversus thoracis muscle plane block (TTMPB) in the minimally invasive closure of transthoracic VSD in paediatric patients. Methods. From September 28, 2017, to July 25, 2022, a total of 119 paediatric patients scheduled
-
Acupuncture for Chronic Prostatitis or Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-14 Juanhong Pan, Song Jin, Quan Xie, Ying Wang, Zhipeng Wu, Jianfeng Sun, Tai Pin Guo, Di Zhang
Background. Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex male dysfunction, mostly seen in young and middle-aged men with a history of more than 3 months. As a traditional therapy of Traditional Chinese Medicine, acupuncture has been proven an effective method to treat CP/CPPS in recent years. Though some meta-analyses on acupuncture for chronic prostatitis were published
-
Characteristics and Outcomes of Patients Receiving Physical Therapy for Low Back Pain with a Nociplastic Pain Presentation: A Secondary Analysis Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-10 Abigail T. Wilson, Joseph L. Riley, Mark D. Bishop, Jason M. Beneciuk, Yenisel Cruz-Almeida, Joel E. Bialosky
Introduction. Individuals with low back pain (LBP) may be classified based on mechanistic descriptors, such as a nociplastic pain presentation (NPP). The purpose of this secondary analysis was to examine the frequency and characteristics of patients with a NPP referred to physical therapy with LBP. Additionally, we characterized patients with LBP meeting the criteria for NPP by demographic, clinical
-
A Cross-Sectional and Longitudinal Study of Pain among Middle-Aged and Older Adults in Thailand Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-9 Supa Pengpid, Karl Peltzer
Objective. The present study aimed to assess the prevalence and risk factors of pain among ageing adults in Thailand. Methods. Cross-sectional and longitudinal data were analysed from two consecutive national waves of the Health, Aging, and Retirement in Thailand (HART) study in 2015 and 2017. The dependent variable pain was defined as moderate or severe pain in any of the 13 areas of the body over
-
Analgesic Efficacy of Intravenous Ibuprofen in the Treatment of Postoperative Acute Pain: A Phase III Multicenter Randomized Placebo-ControlledDouble-Blind Clinical Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-7 Hong-Su Zhou, Ting-Ting Li, Yu Pi, Ting-Hua Wang, Fei Liu, Liu-Lin Xiong
Objective. To evaluate the analgesic efficacy and safety of different does of intravenous ibuprofen (IVIB) in the treatment of postoperative acute pain. Methods. Patients with an intravenous (IV) patient-controlled analgesia device after abdominal or orthopedic surgery were randomly divided into placebo, IVIB 400 mg, and IVIB 800 mg groups. The first dosage of study medicines was given intravenously
-
Ultrasound-Guided Rhomboid Block versus Paravertebral Block in Postoperative Analgesia for Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Controlled Clinical Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-3-1 Yan Wang, Xiaoping Gu, Simin Huang, Minke Shi, Xiaofeng He, Zhengliang Ma
Introduction. The anesthetic efficacy of the ultrasound-guided rhomboid intercostal block (RIB) in alleviating postoperative pain has been well concerned. This study aims to compare the effectiveness between ultrasound-guided RIB and paravertebral block (PVB) in alleviating acute pain following video-assisted thoracic surgery. Methods. It was a prospective, randomized, double-blinded clinical trial
-
Comparison of the Postoperative Analgesic Effects between Ultrasound-Guided Transmuscular Quadratus Lumborum Block and Thoracic Paravertebral Block in Laparoscopic Partial Nephrectomy Patients: A Randomized, Controlled, and Noninferiority Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-21 Jin Wang, Xulei Cui, Liying Ren, Xu Li, Yuelun Zhang, Yi Xie, Zhigang Ji, Yuguang Huang
Background. This prospective, randomized, double-blinded, noninferiority study aimed to compare the effects of analgesia and recovery between transmuscular quadratus lumborum block (TMQLB) and paravertebral block (PVB). Methods. Sixty-eight, American Society of Anesthesiologists level I–III patients, who underwent laparoscopic partial nephrectomy in Peking Union Medical College Hospital were randomly
-
Revealing the Central Mechanism of Acupuncture for Primary Dysmenorrhea Based on Neuroimaging: A Narrative Review Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-18 Benlu Chen, Qin Guo, Qiwen Zhang, Zhong Di, Quanai Zhang
Objective. The central mechanism of acupuncture for primary dysmenorrhea was explored by summarizing the changes in different regional networks of the brain induced by acupuncture stimulation by analyzing the existing studies. Methods. The original studies were collected and selected from three English databases such as PubMed and four Chinese databases as China Knowledge Network (CNKI). The main keyword
-
Effects of a Rehabilitation Program Combined with Pain Management That Targets Pain Perception and Activity Avoidance in Older Patients with Acute Vertebral Compression Fracture: a Randomised Controlled Trial Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-13 Hideki Kataoka, Tatsuya Hirase, Kyo Goto, Yutaro Nomoto, Yutaro Kondo, Koichi Nakagawa, Junichiro Yamashita, Kaoru Morita, Yuichiro Honda, Junya Sakamoto, Minoru Okita
This study aimed to investigate the effect of a rehabilitation program combined with pain management targeting pain perception and activity avoidance on multifaceted outcomes in older patients with acute vertebral compression fractures (VCFs). We randomised 65 older adults with acute VCFs to either an intervention group (n = 32), involving usual rehabilitation combined with pain management that targeted
-
Soluble Epoxide Hydrolase Inhibitor TPPU Alleviates Nab-Paclitaxel-Induced Peripheral Neuropathic Pain via Suppressing NF-κB Signalling in the Spinal Cord of a Rat Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-8 Xing Wei, Lijun Jia, Yaqing Zhou, Weimiao Li, Changyou Shan, Shuqun Zhang, Yonglin Zhao
Objective. Paclitaxel-induced peripheral neuropathy (PIPN) is a debilitating and difficult-to-treat side effect of paclitaxel. Soluble epoxide hydrolase (sEH) can rapidly metabolize the endogenous anti-inflammatory mediators’ epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids. This study aimed to assess whether the sEH inhibitor N-(1-(1-oxopropy)-4-piperidinyl]-N′-(trifluoromethoxy)
-
Assessment of the Factors Influencing the Patient’s Comprehension of the Informed Consent to Interventional Pain Procedures Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-8 Mohammad Ghorbanhoseini, Kyle Kang, Allen Yang, Mohammadreza Abbasian, Eduard Vaynberg
Background. Informed consent is the first step of every medical procedure and is considered a standard of care for patients undergoing medical interventions. Our study seeks to evaluate patients’ understanding of the procedure they consented to and the factors affecting the degree of understanding. Methods. In this cross-sectional study, we used an anonymous postprocedural questionnaire to assess our
-
Do Temporomandibular Disorder Patients with Joint Pain Exhibit Forward Head Posture? A Cephalometric Study Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-2 Chu-Qiao Xiao, Yi-Dan Wan, Ya-Qi Li, Zhe-Bin Yan, Qiao-Yu Cheng, Pei-Di Fan, Yi Huang, Xiao-Yi Wang, Xin Xiong
Purpose. To evaluate head and cervical posture in individuals with or without temporomandibular disorders (TMDs) and to assess the correlations between pain, severity of symptoms, and posture. Methods. A total of 384 patients (129 males and 255 females) was included. The Fonseca Anamnestic Index (FAI) was used to assess the severity and prevalence of TMD and the presence of temporomandibular joint
-
A Potential Objective Sign of Central Sensitization: Referred Pain Elicited by Manual Gluteus Minimus Muscle Exploration is Coincident with Pathological Autonomic Response Provoked by Noxious Stimulation Pain Res. Manag. (IF 2.9) Pub Date : 2023-2-2 Elzbieta Skorupska, Tomasz Dybek, Michał Rychlik, Marta Jokiel, Paweł Dobrakowski, Anna Szczerba, Daria Wotzka, Anna Jankowska
Referred pain/sensation provoked by trigger points suits the nociplastic pain criteria. There is a debate over whether trigger points are related to a peripheral phenomenon or central sensitization (CS) processes. Referred pain is considered a possible sign of CS, which occurs probably mainly due to the abnormal activity of the immune and autonomic nervous systems. To confirm abnormal autonomic reactivity
-
Accurate Diagnosis and Treatment of Painful Temporomandibular Disorders: A Literature Review Supplemented by Own Clinical Experience Pain Res. Manag. (IF 2.9) Pub Date : 2023-1-31 Adam Andrzej Garstka, Lidia Kozowska, Konrad Kijak, Monika Brzózka, Helena Gronwald, Piotr Skomro, Danuta Lietz-Kijak
Introduction. Temporomandibular disorders (TMD) is a multifactorial group of musculoskeletal disorders often with combined etiologies that demand different treatment plans. While pain is the most common reason why patients decide to seek help, TMD is not always painful. Pain is often described by patients as a headache, prompting patients to seek the help of neurologists, surgeons, and ultimately dentists