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A Meta-Analysis of MiRNA-497 and Prognosis of Hepatocellular Carcinoma Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2024-3-18 Zhiqiang Xie, Qingzhi Hao, Rongrong Zhu, Ruiping Ma
Background. Recently, microRNA-497 (miR-497) has been reported as a prognostic marker for hepatocellular carcinoma (HCC). However, there is no systematic study summarizing these data. Herein, we elucidated the prognostic role of miR497 in HCC by using meta-analysis. Methods. We systematically searched Embase, PubMed, Web of Science, and, China National Knowledge Infrastructure for relevant studies
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The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2024-3-18 Shu Zhou, Qi Sun, Ning Gao, Zekai Hu, Junjun Jia, Jiangwei Song, Guocong Xu, Aiqiang Dong, Weiliang Xia, Jiafeng Wu
Background. While observation studies have shown a positive correlation between inflammatory bowel disease (IBD) and the risk of nonmalignant digestive system diseases, a definitive causal relationship has not yet been clearly established. Methods. Mendelian randomization (MR) was employed to investigate the potential causal association between genetic susceptibility to IBD and nonmalignant gastrointestinal
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Hepatitis C Virus Infection and Hospital-Related Outcomes: A Systematic Review Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2024-3-7 Michelle Ng, Patrizia Maria Carrieri, Lindila Awendila, Maria Eugenia Socías, Rod Knight, Lianping Ti
Background. People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use. Direct-acting antivirals (DAAs) have the potential to alleviate this burden; however, the evidence on the impact of HCV infection and hospital outcomes is undetermined. This systematic review aims to assess this research gap, including how DAAs
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Hepatitis C Attributable Healthcare Costs and Mortality among Immigrants: A Population-Based Matched Cohort Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2024-2-24 Aysegul Erman, Yeva Sahakyan, Karl Everett, Christina Greenaway, Naveed Janjua, Jeffrey C. Kwong, William W. L. Wong, Hong Lu, Beate Sander
Background. Data on the economic burden of chronic hepatitis C (CHC) among immigrants are limited. Our objective was to estimate the CHC-attributable mortality and healthcare costs among immigrants in Ontario, Canada. Methods. We conducted a population-based matched cohort study among immigrants diagnosed with CHC between May 31, 2003, and December 31, 2018, using linked health administrative data
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Prevalence of Esophageal Eosinophilia, Eosinophilic Esophagitis, and Lymphocytic Gastritis in Children with Celiac Disease: A Saudi Tertiary Center Experience Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2024-1-9 Meshari A. Alaifan, Ammar Khayat, Rana Y. Bokhary, Abdulhameed Ibrahim, Yagoub Bin-Taleb, Bakr H. Alhussaini, Omar I. Saadah
Background. Celiac disease (CD) is an immune-mediated enteropathy that has been associated with other immune-related gastrointestinal disorders, such as eosinophilic esophagitis (EoE) and lymphocytic gastritis (LG). To our knowledge, this is the first study in Saudi Arabia that has described such an association. Aim. To evaluate the prevalence of EoE and LG in children and adolescents with CD. Methods
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Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-κB Signaling Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-12-29 Lei Zhu, Zhimin Dou, Wei Wu, Qiliang Hou, Sen Wang, Ziqian Yuan, Bin Li, Jian Liu
Sepsis is an inflammatory reaction disorder state that is induced by infection. The activation and regulation of the immune system play an essential role in the development of sepsis. Our previous studies have shown that ghrelin ameliorates intestinal dysfunction in sepsis. Very little is known about the mechanism of ghrelin and its receptor (GHSR) on the intestinal barrier and the immune function
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Prevalence of Hepatitis B and Hepatitis C Viral Infections and Their Associated Factors among Diabetic Patients Visiting Debre Tabor Referral Hospital, Northwest Ethiopia, 2021: A Cross-Sectional Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-11-17 Debaka Belete, Dessie Kassaw, Tesfaye Andualem
Background. Viral hepatitis is a global public health problem that affects millions of people each year, causing disability and death. Hepatitis B and C viruses are the most common causes of viral hepatitis and are associated with chronic liver disease, cirrhosis, and hepatocellular carcinoma. The primary site of infection for these viruses is the liver, the primary site of hormone and glucose metabolism
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Combined Age with Mean Decrease Rates of Total Bilirubin and MELD Score as a Novel and Simple Clinical Predictor on 90-Day Transplant-Free Mortality in Adult Patients with Acute Liver Failure Undergoing Plasma Exchange: A Single-Center Retrospective Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-11-7 Di Jin, Kai Kang, Bing-zhu Yan, Jian-nan Zhang, Jun-bo Zheng, Zhi-hui Wang, Di Wu, Yu-jia Tang, Xin-tong Wang, Qi-qi Lai, Yang Cao, Hong-liang Wang, Yang Gao
Background. Acute liver failure (ALF), previously known as fulminant hepatic failure, has become a common, rapidly progressive, and life-threatening catastrophic hepatic disease in intensive care unit (ICU) due to the continuous increase in drug abuse, viral infection, metabolic insult, and auto-immune cause. At present, plasma exchange (PE) is the main effective alternative treatment for ALF in ICU
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A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-11-3 Xiaoyun Zhang, Chaogui Tang, Jianchun Lian, Yuzhang Jiang
Studies have established a correlation between α2-macroglobulin-like 1 (A2ML1) and the prognosis of lung, pancreatic, and breast cancers; however, research on its involvement in the pathogenesis of esophageal carcinoma remains limited. Therefore, in this study, we aimed to investigate the role of A2ML1 in the progression of esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining was
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miR-325-3p Reduces Proliferation and Promotes Apoptosis of Gastric Cancer Cells by Inhibiting Human Antigen R Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-9-19 Zhengwei Huang, Yacan Luo, Congcong Chen, Chaoyang Zhou, Zhengkang Su, Chang Cai, Xi Li, Wenzhi Wu
Human antigen R (HuR), also known as ELAVL1, is a widely expressed RNA-binding protein (RBP) that has a significant impact on the development and advancement of tumors. Our previous study found that 5-fluorouracil (5-FU) may impede the proliferation and increase apoptosis in gastric cancer cells by reducing the nucleocytoplasmic shuttling of HuR. However, how posttranscriptional regulation influences
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The Potential Dual Role of H2.0-like Homeobox in the Tumorgenesis and Development of Colorectal Cancer and Its Prognostic Value Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-9-9 Shuo Chen, Lin Zhang, Kai Wang, Jizhen Huo, Siqi Zhang, Xipeng Zhang
Background. H2.0-like homeobox (HLX) is highly expressed in several hematopoietic malignancies. However, the role of HLX in the carcinogenesis and progression of colorectal cancer (CRC) patients has rarely been reported. Methods. In this study, the data were collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. The diagnostic value of HLX was analyzed by the R package “pROC
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Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-8-8 Shujun Wang, Yiping Wang, Hui Zhu, Miaohui Chen, Liang Zhang
Gambogic acid (GA) is a natural xanthonoid secreted by Garcinia hanburyi tree. It possesses anti-cancer activity in various types of cancers. In gastric cancer, it inhibits cell proliferation through increasing apoptosis. However, whether necroptosis is involved in the GA-induced proliferation inhibited in gastric cancer is unknown. In the present study, we found that RIPK1 specific inhibitor necrostatin-1
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Platelet-to-Monocyte Ratio as a Novel Promising Agent for the Prognosis of Hepatitis B Virus-Associated Decompensated Cirrhosis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-7-14 Jun Zhou, Xin Li, Min Wang, Chunrong Gu, Jingping Liu
Aim. The present study aimed at investigating associations of the platelet-to-monocyte ratio (PMR), a novel hematological indicator of inflammatory responses with 30-day outcomes in patients with HBV-associated decompensated cirrhosis (HBV-DeCi). Methods. We recruited 329 patients with HBV-DeCi for this retrospective study and extracted baseline clinical data and laboratory characteristics from medical
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Plasma S100A8 and S100A9 Are Strong Prognostic Factors for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-7-10 Yao Zhang, Xueyun Zhang, Jiajia Han, Yifei Guo, Jingjing He, Feifei Yang, Richeng Mao, Yuxian Huang, Jiming Zhang
Objectives. The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver failure (ACLF) are inseparable from the role of systemic inflammatory response. S100A8 and S100A9 are associated with the excessive cytokine storm and play a decisive part within the process of inflammation. We aimed to clarify the role of them in predicting prognosis of hepatitis B virus-related ACLF
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Diabetes and Metabolic Disorders: Their Impact on Cardiovascular Events in Liver Transplant Patients Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-6-23 Simone Di Cola, Giulia Cusi, Lucia Lapenna, Jakub Gazda, Stefano Fonte, Marco Mattana, Gianluca Mennini, Patrizio Pasqualetti, Manuela Merli
Cardiovascular diseases are currently one of the most important causes of morbidity and mortality in liver transplant patients over the long term. Therefore, evaluating prognostic factors for cardiovascular events (CVEs) in this population is essential for taking preventive measures. The aim of this study was to identify the impact of diabetes and other metabolic disorders on CVEs in liver transplant
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Prediction of Liver Steatosis and Fibrosis Based on Clinical Variables Using a Large National Survey Database Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-5-24 Yanal Alnimer, Touleen Alnimer
Background. Vibration-controlled transient elastography (VCTA) and controlled attenuation parameter (CAP) are used more frequently to diagnose liver fibrosis and steatosis among nonalcoholic fatty liver disease patients. However, limited robust data are available on the clinical variables strongly related to these disorders and who needs to be referred for screening. Methods. We used the National Health
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Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-4-26 Jiabing Wang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi
Background. The drug-eluting beads transarterial chemoembolization (DEB-TACE) has already been used in hepatic malignancies. We aim to evaluate the efficacy and safety of DEB-TACE in treating primary or secondary liver cancer. Methods. We retrospectively evaluated 59 patients with hepatic malignancies, including 41 patients with primary liver cancer and 18 patients with secondary liver cancer, between
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Effect of COVID-19 Pandemic-Related Delays in Chemoembolization on the Survival of Patients with Hepatocellular Carcinoma Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-4-14 Kittipitch Bannangkoon, Keerati Hongsakul, Teeravut Tubtawee, Phurich Janjindamai
Background and Aims. COVID-19 has led to potential delays in liver cancer treatment, which may have undesirable effects on the prognosis of patients. We aimed to quantify the COVID-19 pandemic impact on the survival of patients with hepatocellular carcinoma (HCC) who underwent transarterial chemoembolization (TACE). Methods. A retrospective study was conducted in patients with HCC who underwent TACE
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Endoscopic Management Using Novel Haemostatic Agents for Immediate Bleeding during Endoscopic Retrograde Cholangio-Pancreatography Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-4-10 Cosmas Rinaldi Adithya Lesmana, Sharon Sandra, Maria Satya Paramitha, Rino Alvani Gani, Laurentius A. Lesmana
Bleeding after endoscopic sphincterotomy (ES) remains as a major challenge during ERCP procedure. Standard endoscopic haemostatic procedures have demonstrated good performance for bleeding control. Novel endoscopic haemostatic agents have also been widely used in gastrointestinal bleeding management. Regardless, there is still a paucity of high-quality evidence evaluating the practicality of these
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Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-4-8 Tao Du, Shun Zhang, Xi-Mao Cui, Ren-Hao Hu, Hai-Yan Wang, Jian-Juan Jiang, Jun Zhao, Lan Zhong, Xiao-Hua Jiang
Purpose. Our objective was to compare the value of positron emission tomography/magnetic resonance imaging (PET/MRI) with the new imaging agent [68Ga]Ga-DOTA-FAPI-04 and the traditional imaging agent [18F]FDG for the preoperative diagnosis of gastric cancer. Methods. Forty patients with gastric cancer diagnosed by gastroscopy in gastrointestinal surgery at our hospital from June 2020 to January 2021
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Analysis of Complications and Risk Factors Other than Bleeding before and after Endoscopic Treatment of Esophagogastric Variceal Bleeding in Patients with Liver Cirrhosis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-3-29 Xiaowei Duan, Xing He, Hezhong Yan, Haiqing Li, Jiaoxue Wang, Shicun Guo, Zhengwei Zha, Qianqian Zhang, Yuchuan Bai, Jiayi Zhang, Jun Tang, Derun Kong
Objective. To identify any concomitant complications other than bleeding (COTB) before and after endoscopic treatment of esophagogastric variceal bleeding (EGVB) in liver cirrhosis patients and explore the underlying risk factors. Materials and Methods. Cirrhotic patients complicated with EGVB, who underwent interventional endoscopic treatments in our hospital from November 2017 to August 2020, were
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SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-3-17 Ping Qiu, Xing Li, Min Gong, Ping Wen, Jianbo Wen, Linfang Xu, Guiliang Wang
Gastric cancer (GC) is a common digestive tract malignancy worldwide. N-myristoyltransferase 1 (NMT1) has been implicated in many cancers, but its association with gastric cancer remains to be clarified. Thus, this paper elucidated the role of NMT1 in GC. The NMT1 expression level in GC and normal tissue samples as well as the relationship between NMT1 high or low expression and overall survival in
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Liver Assessment in Patients with Ataxia-Telangiectasia: Transient Elastography Detects Early Stages of Steatosis and Fibrosis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-3-11 H. Donath, S. Wölke, V. Knop, U. Heß, R. P. Duecker, J. Trischler, T. Poynard, R. Schubert, S. Zielen
Background. Ataxia-telangiectasia (A-T) is a rare autosomal-recessive multisystem disorder characterized by pronounced cerebellar ataxia, telangiectasia, cancer predisposition, and altered body composition. Liver diseases with steatosis, fibrosis, and hepatocellular carcinoma are frequent findings in older patients but sensitive noninvasive diagnostic tools are lacking. Objectives. To determine the
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Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients? Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-3-8 Yan-Yu Qiu, Yi-Xin Zeng, Yong Cheng
Purpose. The purpose of the current study was to determine whether there is a difference between high levels of microsatellite instability (MSI-H) and microsatellite stability (MSS) in DNA mismatch repair-deficient (DMMR) colorectal cancer (CRC) patients. Methods. A total of 452 CRC patients with DMMR from December, 2014, to April, 2021, in our hospital were selected retrospectively. However, only
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Higher Neutrophil-to-Lymphocyte Ratio (NLR) Is a Preoperative Inflammation Biomarker of Poor Prognosis in HIV-Infected Patients with Colorectal Cancer: A Retrospective Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-3-6 Li Deng, Yanhui Si, Qian Wu, Ye Cao, Shixian Lian, Lei Li
Background. The serum systemic inflammation biomarkers are known predictors of colorectal cancer (CRC) patient prognosis. However, their significance in human immunodeficiency virus (HIV)-infected patients with CRC has not been studied. To address this gap, we conducted a retrospective study to evaluate the prognostic value of preoperative systemic inflammation biomarkers in HIV-infected patients with
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Disparate Intent-to-Treat Outcomes for Pediatric Liver Transplantation Based on Indication Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-3-2 Anna Lang, Cameron Goff, Ashley Montgomery, Jake Lynn, Spoorthi Kamepalli, John Goss, Abbas Rana
Background. The impact of indication for pediatric liver transplantation on waitlist and post-transplant mortality outcomes is well known, but the impact on intent-to-treat outcomes has not been investigated. Intent-to-treat survival analysis is important in this study because it is more comprehensive, combining the transplant outcomes of waitlist mortality, post-transplant mortality, and transplant
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The Impact of Serum Parameters Associated with Kidney Function on the Short-Term Outcomes and Prognosis of Colorectal Cancer Patients Undergoing Radical Surgery Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-2-27 Bin Zhang, Xu-Rui Liu, Xiao-Yu Liu, Bing Kang, Chao Yuan, Fei Liu, Zi-Wei Li, Zheng-Qiang Wei, Dong Peng
Purpose. The current study was designed to investigate the impact of blood urea nitrogen (BUN), serum uric acid (UA), and cystatin (CysC) on the short-term outcomes and prognosis of colorectal cancer (CRC) patients undergoing radical surgery. Methods. CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in a single clinical centre. The short-term outcomes, overall survival
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Relationship of Helicobacter pylori Infection with Nonalcoholic Fatty Liver Disease: A Meta-Analysis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-1-25 Guangqin Xu, Shaoze Ma, Liyan Dong, Nahum Mendez-Sanchez, Hongyu Li, Xingshun Qi
Background and Aims. Helicobacter pylori (H. pylori) and nonalcoholic fatty liver disease (NAFLD) have become increasingly recognized, both of which affect human health globally. The association of H. pylori infection with NAFLD remains unclear. Methods. PubMed, EMBASE, and Cochrane Library databases were searched. Only a random-effects model was used. Odds ratios (ORs) and risk ratios (RRs) with 95%
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Population- and Gender-Based Investigation for Prevalence of Helicobacter pylori in Dhamar, Yemen Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-1-25 Dhary A. Almashhadany, Sara M. Mayas, Hero I. Mohammed, Abdulwahed A. Hassan, Izhar U. H. Khan
Among 35 species of genus Helicobacter, H. pylori is the most common causative agent of human gastritis, peptic ulcer, and gastric cancer. The infection can spread through direct human-to-human contact, fecal–oral route, and contaminated water. The study was designed to investigate the rate of prevalence of H. pylori in the population of Dhamar, Yemen. In this one-year study, 460 including 250 male
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Surgical Management of Recurrence of Primary Intrahepatic Bile Duct Stones Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-1-23 HongTian Xia, HangYu Zhang, XianLei Xin, Bin Liang, Tao Yang, Yang Liu, Jing Wang, XiangFei Meng
Background. The surgical treatment of primary intrahepatic bile duct stones is associated with high rates of postoperative complications, stone recurrence, and reoperation. This study aimed to report an 11-year experience in the management of postoperative recurrence of intrahepatic bile duct stones, analyze the causes of the reoperation, and establish appropriate surgical procedures. Materials and
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Construction and Analysis of Hepatocellular Carcinoma Prognostic Model Based on Random Forest Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2023-1-12 Yikai Wang, Le Ma, Pengjun Xue, Bianni Qin, Ting Wang, Bo Li, Lina Wu, Liyan Zhao, Xiongtao Liu
Introduction and Aims. Hepatocellular carcinoma (HCC) is one of the most lethal tumors of the digestive system, but its mechanisms remain unclear. The purpose of this study was to study HCC-related genes, build a survival prognosis prediction model, and provide references for treatment and mechanism research. Methods. Transcriptome data and clinical data of HCC were downloaded from the TCGA database
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Diagnostic Delay in Coeliac Disease: A Survey among Danish Patients Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-28 Line Lund Kårhus, Susanne Hansen, Jüri J. Rumessen, Allan Linneberg
Background. Coeliac disease affects around 1% of the population, although many cases remain undiagnosed. Underdiagnosis and diagnostic delay in coeliac disease may cause health complications and be a burden for both the patient and society. Casuistic reports indicate that the diagnostic delay may be significant in Danish patients. Aim. To investigate the diagnostic delay among Danish patients with
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A Comprehensive Hepatitis B Surface Antigen-Positive Patient-Centered Screening and Linkage to Care Strategies Targeting Microelimination of Hepatitis C Virus Infection in Chongqing, China Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-27 Dachuan Cai, Dazhi Zhang, Peng Hu, Hong Ren
Background and Aims. The likelihood of coinfection increases in regions where HBV is endemic because of the similar transmission route. China is another endemic nation, with 5.9% of the population being HBsAg-positive. This study aimed to evaluate the prevalence of HCV antibody positivity in HBsAg-positive subjects, HCV RNA positivity in anti-HCV positive subjects, and HBV/HCV coinfection with the
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Hsa_circ_0006988 Promotes Sorafenib Resistance of Hepatocellular Carcinoma by Modulating IGF1 Using miR-15a-5p Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-24 Rui Qiu, Zhifeng Zeng
Background. Hepatocellular carcinoma (HCC) is the most frequently occurring cancer and contributes to the largest number of cancer-associated deaths worldwide. Recent evidence suggests that circular RNAs (circRNAs), which are critical for HCC etiology and metastasis, are distinctly modulated in HCC. Nevertheless, the underlying mechanism of circRNA-mediated sorafenib resistance (SOR) in HCC is yet
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Screening Patterns of Nonalcoholic Fatty Liver Disease in Children with Obesity in Canadian Primary Care: A Cross-Sectional Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-24 Rachael Morkem, Rebecca Theal, David Barber, Jennifer Flemming, John Queenan, Mohit Kehar
Background. Nonalcoholic fatty liver disease (NAFLD) is the most common pediatric chronic liver disease, and children with a body mass index (BMI) ≥95th percentile are recommended to be screened for NAFLD by liver enzymes. Objectives. This study aimed to determine the frequency and predictors of screening for NAFLD among children with obesity in Canada and to evaluate a sample of children with suspected
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Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-23 Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Zheng Jiang, Jinjun Guo
Background. Cancer stem cells (CSCs) are involved in liver metastasis in colorectal cancer (CRC). Activin and hepatocyte growth factor (HGF) are important regulators of stem cell properties. This study was performed to explore the effect of activin and HGF on CRC invasion and metastasis. The key genes involved in the action of activin and HGF in CRC were identified. Methods. HCT116 CRC cells were sequentially
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Overexpression of microRNA-211 in Functional Dyspepsia via Downregulation of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) by Increasing Phosphorylation of p38 MAPK Pathway Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-14 Jue Wang, Sai Gu, Bo Qin
Background. Overexpression of miRNA-211 suppresses the differentiation of bone marrow stem cells into intestinal ganglion cells via downregulation of GDNF, a regulator of intestine barrier function. The study aimed to investigate the interaction between miR-211 and GDNF on intestinal epithelial cells. Methods. The expression levels of miR-211 and GDNF in duodenal biopsy specimens from FD patients and
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Pumilio RNA-Binding Family Member 1 Plays a Promoting Role on Pancreatic Cancer Angiogenesis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-14 Haisu Dai, Yan Jiang, Zhipeng Liu, Xingxing Su, Yishi Yang, Zhiyu Chen
Our previous studies showed that Pumilio RNA-binding family member 1 (PUM1) gene is abnormally expressed in pancreatic cancer (PC) tissues, and its knockdown suppresses the growth and metastasis of PC cells. Here, we aimed to further investigate its role in angiogenesis. Immunohistochemical assays were carried out to analyze CD31 and PUM1 expression levels in PC tissues and in subcutaneous xenograft
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The Relationship and Changes of Liver Blood Supply, Portal Pressure Gradient, and Liver Volume following TIPS in Cirrhosis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-8 Jinghong He, Jinyu Li, Changxing Fang, Ying Qiao, Duiping Feng
Aim. Transjugular intrahepatic portosystemic shunt (TIPS) alters the liver blood supply and reduces portal pressure. This study was to investigate the changes and associations of the hepatic blood flow, liver volume, and portal pressure gradient (PPG) after TIPS in liver cirrhosis. Methods. Twenty-one patients with liver cirrhosis who received TIPS were recruited. The contrast CT images were used to
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Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-8 Parisa Shiri Aghbash, Hamed Ebrahimzadeh Leylabadlo, Hamidreza Fathi, Mohaddeseh Bahmani, Rojin Chegini, Hossein Bannazadeh Baghi
Following the SARS-CoV-2 outbreak and the subsequent development of the COVID-19 pandemic, organs such as the lungs, kidneys, liver, heart, and brain have been identified as priority organs. Liver diseases are considered a risk factor for high mortality from the COVID-19 pandemic. Besides, liver damage has been demonstrated in a substantial proportion of patients with COVID-19, especially those with
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The Characteristics of Diverticular Disease in Caribbean Population: A Control Group Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-7 Moana Gelu-Simeon, Matthieu Schnee, Marie-Josée Lafrance, Pauline Plazy-Chabrand, Anne-Sophie Schneck, Georgette Saint-Georges, Marceline Alexis, Stéphanie Delumeau, Philippe Montigny, Roger Faroux, Jérome Dimet, Eric Saillard
Background. Diverticulosis is not well characterized in the Caribbeans. Our aim was to compare the anatomical presentation of colonic diverticulosis in African Caribbeans (group AC) versus Europeans (group E) and severity. Methods. We conducted a prospective controlled study involving 274 patients admitted for lower gastrointestinal haemorrhage (LGIH) in France (center 1: Guadeloupe; center 2: La Roche-sur-Yon);
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Reduction of Hepatitis B Surface Antigen May Be More Significant in PEGylated Interferon-Alpha Therapy Combined with Nucleotide Analogues than Combined with Nucleoside Analogues in Chronic Hepatitis B Patients: A Propensity Score Matching Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-7 Yiran Xie, Haoxiang Zhu, Yifei Guo, Zhenxuan Ma, Xun Qi, Feifei Yang, Richeng Mao, Jiming Zhang
Background. Nucleotide analogues (NTs) monotherapy may have a more significant effect on reducing hepatitis B surface antigen (HBsAg) than nucleoside analogues (NSs) due to their immunomodulatory function. However, this superiority remains unknown when combined with PEGylated interferon α (PegIFNα). Therefore, this study aimed to explore whether NTs have more significant antiviral effects than NSs
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Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis? Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-12-6 Aaron Wetten, Laura Ogle, George Mells, Vinod S. Hegade, Laura Jopson, Margaret Corrigan, Jeremy Palmer, Maja Johansson, Torbjörn Bäckström, Magnus Doverskog, David E. J. Jones, Jessica K. Dyson
Background and Aims. A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment. Allopregnanolone, a neurosteroid, is a positive allosteric modulator of gamma-aminobutyricacid-A (GABA-A) receptors, associated with disordered mood, cognition, and memory. This study
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Comprehensive Analysis of N6-Methyladenosine (m6A) RNA Methylation Regulators and Tumour Microenvironment Cell Infiltration Involving Prognosis and Immunotherapy in Gastroesophageal Adenocarcinomas Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-21 Duanrui Liu, Mingjie Yuan, Zongming Wang, Liping Sun, Yusong Fang, Xiaoli Ma, Lulu Zhang, Yuanxin Xing, Jingyu Zhu, Yunyun Liu, Wenshuai Zhu, Shuqin Bao, Yanfei Jia, Yunshan Wang
Objective. Gastroesophageal adenocarcinoma (GEA) is a high deadly and heterogeneous cancer. RNA N6-methyladenosine (m6A) modification plays a non-negligible role in shaping individual tumour microenvironment (TME) characterizations. However, the landscape and relationship of m6A modification patterns and TME cell infiltration features remain unknown in GEA. Methods. In this study, we examined the TME
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Virological Changes of Chronic Hepatitis B Patients with Minimally Elevated Levels of Alanine Aminotransferase: A Meta-Analysis and Systematic Review Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-16 Xiyao Chen, Xingrong Zheng, Hewei Wu, Boxiang Zhang, Liang Peng, Chan Xie
Background. Chronic hepatitis B (CHB) patients with normal or minimally increased levels of alanine aminotransferase (ALT) are still at the risk of hepatocellular carcinoma, cirrhotic events, and mortality. However, there is a debate over the initiation of antiviral treatment for these patients. This systematic review and mate-analysis aimed to explore this problem. Methods. MEDLINE (PubMed), EMBASE
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Immunohistochemical Differentiation between Western and East Asian Types of CagA-Positive Helicobacter pylori in Gastric Biopsy Samples Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-12 Daisuke Kobayashi, Keisuke Uchida, Asuka Furukawa, Takashi Ito, Luis Masuo Maruta, Heinrich Bender Kohnert Seidler, Aloisio Felipe-Silva, Masaki Sekine, Noboru Ando, Yuka Toyama, Yusuke Chino, Keiko Miura, Kurara Yamamoto, Takumi Akashi, Yoshinobu Eishi, Kenichi Ohashi
Background. Cag A-positive Helicobacter pylori isolated from human gastric mucosa is categorized as a Western or East Asian allele-type based on whether the cagA gene encodes an EPIYA-C or EPIYA-D motif. We aimed to differentiate between the 2 types of H. pylori by immunohistochemistry (IHC) using formalin-fixed paraffin-embedded (FFPE) gastric biopsy samples. Materials and Methods. We developed 2
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Construction of a Prognostic Model Based on Cuproptosis-Related lncRNA Signatures in Pancreatic Cancer Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-11 Wenkai Jiang, Yan Du, Wenlong Zhang, Wence Zhou
Aim. The aim of this study is to identify cuproptosis-related lncRNAs and construct a prognostic model for pancreatic cancer patients for clinical use. Methods. The expression profile of lncRNAs was downloaded from The Cancer Genome Atlas database, and cuproptosis-related lncRNAs were identified. The prognostic cuproptosis-related lncRNAs were obtained and used to establish and validate a prognostic
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Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-8 Bing Yang, Xi Yang, Xumei Tan, Liqing Lu, Wei Fan, Lucía Barbier-Torres, Justin Steggerda, Ting Liu, Heping Yang
The pathogenesis of NAFLD is complex and diverse, involving multiple signaling pathways and cytokines from various organs. Hepatokines, stellakines, adipokines, and myokines secreted by hepatocytes, hepatic stellate cells, adipose tissue, and myocytes play an important role in the occurrence and development of nonalcoholic fatty liver disease (NAFLD). The nuclear factor kappa-light-chain-enhancer of
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The Role of Combining Probiotics in Preventing and Controlling Inflammation: A Focus on the Anti-Inflammatory and Immunomodulatory Effects of Probiotics in an In Vitro Model of IBD Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-8 Shadi Aghamohammad, Amin Sepehr, Seyedeh Tina Miri, Saeideh Najafi, Mohammad R. Pourshafie, Mahdi Rohani
Objective. IBD is an inflammatory disease with abnormalities such as dysbiosis and abnormal immune system activity. Probiotics, as live beneficial microorganisms, play a role in maintaining health through various mechanisms, including the modulation of the immune system and the control of inflammation. Here, we aimed to investigate the efficacy of a probiotic mixture of Lactobacillus spp. and Bifidobacterium
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Nomogram for Predicting Postoperative Portal Venous Systemic Thrombosis in Patients with Cirrhosis Undergoing Splenectomy and Esophagogastric Devascularization Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-4 Miao Chen, Jian-Bo Han, Jia-Kang Zhang, Qing-Hua Shu, Yu-Feng Zhang, Yong-Xiang Yi
Objectives. The aim of the study is to develop a nomogram for predicting postoperative portal venous systemic thrombosis (PVST) in patients with cirrhosis undergoing splenectomy and esophagogastric devascularization. Methods. In total, 195 eligible patients were included. Demographic characteristics were collected, and the results of perioperative routine laboratory investigations and ultrasound examinations
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Risk of Severe Illness and Risk Factors of Outcomes of COVID-19 in Hospitalized Patients with Chronic Liver Disease in a Major U. S. Hospital Network Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-11-3 Arunkumar Krishnan, Laura Prichett, Yisi Liu, Peng-sheng Ting, Saleh A. Alqahtani, Amy K. Kim, Michelle Ma, James P. Hamilton, Tinsay A. Woreta, Po-Hung Chen
Background and Aim. Underlying comorbidities are an emerging risk factor for more severe coronavirus disease 2019 (COVID-19). However, its impact on patients with chronic liver disease (CLD) remains unclear. In addition, there is a paucity of data about whether patients with CLD have an increased risk of requiring intensive care, vasopressor support, or mechanical ventilation (MV). This study aimed
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Drainage of Complex Walled-Off Pancreatic Fluid Collections in LAMS Era: A Multicenter Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-10-29 Thanawat Luangsukrerk, Kamin Harinwan, Stanley Khoo, Pradermchai Kongkam
Background. The lumen-apposing metal stent (LAMS) has been increasingly used for EUS-guided drainage of symptomatic walled-off pancreatic fluid collection (WOPFC) in recent years. Nevertheless, some WOPFCs may require additional drainage methods including another LAMS as a result of complexity of the lesions. This current study aimed to compare clinical parameters of patients with complex WOPFC requiring
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Finding Cases of Hepatitis C for Treatment Using Automated Screening in the Emergency Department is Effective, but What Is the Cost? Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-10-14 David Stephen Prince, Julia Di Girolamo, Joseph Louis Pipicella, Melissa Bagatella, Tahrima Kayes, Frank Alvaro, Michael Maley, Hong Foo, Paul MacConachie Middleton, Miriam Tania Levy
Case detection remains a major challenge for hepatitis C virus (HCV) elimination. We have previously published results from a pilot of an emergency department (ED) semiautomated screening program, SEARCH; Screening Emergency Admissions at Risk of Chronic HCV. Several refinements to SEARCH have been developed to streamline and reduce cost. All direct costs of HCV testing until direct-acting antiviral
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Depletion and Reversal of Hepatocellular Carcinoma Inducing CTL through ER Stress-Dependent PERK-CHOP Signaling Pathway Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-10-10 Mengnan Guo, Wei Wang, Wen Bai, Zekun Bai, Weixi Chen, Yali Su, Jinghua Wu
Aims. In this report, it was investigated that hepatoma cells can cause downregulation of cytotoxic T lymphocyte (CTL) function and tea polyphenols (TPs) can reverse downregulation of CTL function. Methods. The expression of GRP78, PD-1, and TIM-3 was detected by western blotting in CTLL-2 cocultured with Hepa1-6 cells. Moreover, perforin (PRF1) and granzyme B (GzmB) protein levels and ER morphology
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Kiwifruit and Kiwifruit Extracts for Treatment of Constipation: A Systematic Review and Meta-Analysis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-10-6 Mohamed Eltorki, Russell Leong, Elyanne M. Ratcliffe
Introduction. This systematic review aimed to summarize evidence to determine the effectiveness of kiwifruit or kiwifruit extracts in the treatment of constipation. Methods. Electronic databases were searched from inception to May 2022 without any age or language limitations. Eligible studies enrolled participants with constipation who were randomized to receive kiwifruit or kiwifruit extracts vs.
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Virulence Genes of Helicobacter pylori Increase the Risk of Premalignant Gastric Lesions in a Colombian Population Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-9-28 Yeison Carlosama-Rosero, Claudia Acosta-Astaiza, Carlos H. Sierra-Torres, H. Bolaños-Bravo, Andrés Quiroga-Quiroga, Juan Bonilla-Chaves
Background. Genetic variability of Helicobacter pylori is associated with various gastrointestinal diseases; however, little is known about interaction with sociodemographic in the development of premalignant lesions in Colombian patients. Methods. An analytical study was conducted including cases (patients with gastric atrophy, intestinal metaplasia, and gastric dysplasia) and controls (patients with
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Neutrophil to Lymphocyte Ratio and Spontaneous Bacterial Peritonitis among Cirrhotic Patients: A Systematic Review and Meta-analysis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-9-27 Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Jairo Hernandez, Andrew Nguyen, Brandon Lucke-Wold, Shima Nourigheimasi, Shokoufeh Khanzadeh
Background. The goal of this systematic review and meta-analysis was analyzing published studies on the role of neutrophil to lymphocyte ratio (NLR) in infection and spatially spontaneous bacterial peritonitis (SBP) among cirrhotic patients. Methods. PubMed, Web of Science, and Scopus were searched until May 24, 2022. The Newcastle–Ottawa scale was used for quality assessment. Results. Of 14 studies
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Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-9-26 Yizhe Wang, Luxiang Zhao, Zhuozhao Zheng, Yu Zhang
Cirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients’ mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-based flow resistance analysis was proposed. The flow resistance analysis was performed for nine cirrhosis
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Autoimmune Hepatitis with Acute Presentation: Clinical, Biochemical, and Histological Features of 126 Patients Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-9-26 Álvaro Urzúa, Carolina Pizarro, Abraham Gajardo, Rafael Poniachik, Claudia Pavez, Máximo Cattaneo, Javier Brahm, Laura Carreño, Jaime Poniachik
Introduction. Autoimmune hepatitis (AIH) is a chronic liver disease with a relevant inflammatory component and an unknown etiology. Evidence for clinical characteristics and risk factors in large cohorts of patients with acute AIH (AAIH) is lacking. We clinically characterized patients with AAIH, the prevalence of a combined adverse outcome (death or liver transplantation (LT)), and its risk factors
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The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Based on FOLFIRI for Advanced Intrahepatic Cholangiocarcinoma as Second-Line and Successive Treatment: A Real-World Study Can. J. Gastroenterol. Hepatol. (IF 2.7) Pub Date : 2022-9-26 Peixin Huang, Xiaoyong Huang, Yingting Zhou, Guohuan Yang, Qiman Sun, Guoming Shi, Yi Chen
Objective. Intrahepatic cholangiocarcinoma (iCCA) is a primary liver malignancy with a poor prognosis and limited treatment. Cisplatin with gemcitabine is used as the standard first-line chemotherapy regimen; however, there is still no robust evidence for second-line and successive treatments. Although preliminary evidence suggests a vital role of precision therapy or immunotherapy in a subset of patients