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Donor-Recipient Race-Ethnicity Concordance and Patient Survival after Liver Transplantation HPB (IF 2.9) Pub Date : 2024-03-11 Makenna Laffey MD, Eishan Ashwat BS, Hao Lui MD PhD, Xingyu Zhang PhD (Biostat), Christof Kaltenmeier MD, Godwin Packiaraj MD, Andrew Crane MD, Sarmad Alshamery MD, Vikraman Gunabushanam MD, Armando Ganoza MD MBA, Stalin Dharmayan MD, Colin A. Powers MD, Naudia Jonassaint MD MPH MBA, Michele Molinari MD MHS
We assessed the association between patient survival after liver transplantation (LT) and donor-recipient race-ethnicity (R/E) concordance. The Scientific Registry of Transplant Recipients (SRTR) was retrospectively analyzed using data collected between 2002 and 2019. Only adults without history of prior organ transplant and recipients of LT alone were included. The primary outcome was patient survival
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Safety and performance of a synthetic sealant patch aimed to prevent postoperative pancreatic fistula after distal pancreatectomy (SHIELDS) – prospective international multicenter phase II study HPB (IF 2.9) Pub Date : 2024-03-11 Mara R. Goetz MD, Asmus Heumann MD, Claudio Bassi MD, Luca Landoni MD, Karl Khatib-Chahidi MD, Michael Ghadimi MD, Maximillian von Heessen MD, Frederik Berrevoet MD PhD, Filip Gryspeerdt MD, Marc Besselink MD PhD MSc, Eduard A. van Bodegraven MD, Mustapha Adham MD, Johann Pratschke MD, Wenzel Schöning MD, Jakob R. Izbicki MD, Maximilian Bockhorn MD
The incidence for clinically relevant postoperative pancreatic fistulas (CR-POPF) in distal pancreatectomy (DP) ranges up to 25%. None of the available sealants significantly reduce CR-POPF. A new biodegradable sealant patch was able to reduce POPF and to achieve bleeding control in a preclinical porcine DP model. The aim of this first-in-human study was to clinically assess the safety and performance
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Evaluating the Redundancy of Patient-Centered Internet-Based Content for Pancreas Cancer and Pancreaticoduodenectomy HPB (IF 2.9) Pub Date : 2024-03-09 Chase G. Hodkiewicz, McKenzie J. White MD, Jake S. Ankeny MD FACS, Eric H. Jensen MD FACS, Schelomo Marmor PhD MPH, David G. Brauer MD MPHS
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Educational quality of Robotic Whipple videos on YouTube HPB (IF 2.9) Pub Date : 2024-03-06 N. Hwang, P.P. Chao, J. Kirkpatrick, K. Srinivasa, J.B. Koea, S. Srinivasa
Videos on Robotic pancreaticoduodenectomy (RPD) may be watched by surgeons learning RPD. This study sought to appraise the educational quality of RPD videos on YouTube. One hundred videos showing RPD or ‘Robotic Whipple’ were assessed using validated scales (LAP-VEGaS & Consensus Statement Score (CSS)). The association between the scores and characteristics of the video (e.g. order of appearance, provider
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Perspectives on robotic HPB training in the UK: a survey analysis HPB (IF 2.9) Pub Date : 2024-03-04 Z. Raza, R.M. Qazi, A. Pathanki, A.E. Frampton, J. Ahmad
A step–up approach for robotic training in hepato-pancreato-biliary (HPB) surgery has been previously published by our group. The approach was mostly based on personal experience and communications between experts and needed appraisal and validation by the HPB surgical community. At the Great Britain and Ireland HPB Association (GBIHPBA) robotic HPB meeting held in Coventry, UK in October 2022, the
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Hospital variation and outcomes after repeat hepatic resection for colorectal liver metastases: a nationwide cohort study HPB (IF 2.9) Pub Date : 2024-03-04 Michelle R. de Graaff, Joost M. Klaase, Marcel den Dulk, Wouter W. te Riele, Jeroen Hagendoorn, N. Tjarda van Heek, M. Vermaas, Eric J. Th. Belt, Koop Bosscha, Gerrit D. Slooter, Wouter K.G. Leclercq, Mike S.L. Liem, J. Sven D. Mieog, Rutger-Jan Swijnenburg, Ronald M. van Dam, Cees Verhoef, Koert Kuhlmann, Peter van Duijvendijk, Michael F. Gerhards, Paul Gobardhan, Peter van den Boezem, Eric R. Manusama
Approximately 70% of patients with colorectal liver metastases (CRLM) experiences intrahepatic recurrence after initial liver resection. This study assessed outcomes and hospital variation in repeat liver resections (R-LR). This population-based study included all patients who underwent liver resection for CRLM between 2014 and 2022 in the Netherlands. Overall survival (OS) was collected for patients
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Short-term outcomes of laparoscopic extended hepatectomy versus major hepatectomy: a single-center experience HPB (IF 2.9) Pub Date : 2024-03-02 Adriano C. Costa, Alessandro Mazzotta, Fernando Santa-Cruz, Fabricio F. Coelho, Ecoline Tribillon, Brice Gayet, Paulo Herman, Olivier Soubrane
Laparoscopic major hepatectomy (LMH) remains restricted to a few specialized centers and poses a challenge to surgeons performing laparoscopic resections. Laparoscopic extended resections are even more complex and rarely conducted. From a single-institution database, we compared the short-term outcomes of patients who underwent major and extended laparoscopic resections, stratifying the entire retrospective
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Prediction of post-hepatectomy liver failure by preoperative gadoxetate disodium-enhanced magnetic resonance imaging HPB (IF 2.9) Pub Date : 2024-02-28 Johannes C. Lauscher, Matthew E.B. Dixon, George Jada, Mariam Afshin, Konrad Neumann, Helen Cheung, Guillaume Martel, Julie Hallet, Natalie Coburn, Calvin Law, Laurent Milot, Paul J. Karanicolas
Approximately 15% of patients experience post-hepatectomy liver failure after major hepatectomy. Poor hepatocyte uptake of gadoxetate disodium, a magnetic resonance imaging contrast agent, may be a predictor of post-hepatectomy liver failure. A retrospective cohort study of patients undergoing major hepatectomy (≥3 segments) with a preoperative gadoxetate disodium-enhanced magnetic resonance imaging
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The impact of post-hepatectomy liver failure on long-term survival after liver resection for perihilar cholangiocarcinoma HPB (IF 2.9) Pub Date : 2024-02-28 Poowanai Sarkhampee, Weeris Ouransatien, Satsawat Chansitthichok, Nithi Lertsawatvicha, Paiwan Wattanarath
Although post-hepatectomy liver failure (PHLF) can accurately predict short-term mortality of liver resection for perihilar cholangiocarcinoma (pCCA), its significance in predicting long-term overall survival (OS) is still uncertain. Retrospective analysis was performed on patients with pCCA who underwent liver resection between October 2013 and December 2018. The patients were divided into 3 groups;
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Is it resectable? A survey regarding tumor classification and vascular involvement HPB (IF 2.9) Pub Date : 2024-02-28 Ahmer Irfan, Wendy Feng, Vikas Dudeja, Sushanth Reddy, John B. Rose
The anatomic location of the pancreas can result in involvement of major vasculature, which may act as a contraindication to resection. Several classification systems have been developed. We sought to discover the variations in the HPB community determining PDAC resectability. The multiple-choice survey was distributed to all full members of the IHPBA. Questions were asked regarding demographics and
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Predictive score for identifying intrahepatic cholangiocarcinoma patients without lymph node metastasis: a basis for omitting lymph node dissection HPB (IF 2.9) Pub Date : 2024-02-28 Yuya Miura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Yoshiyasu Kato, Shimpei Otsuka, Takeshi Aramaki, Yuko Kakuda, Katsuhiko Uesaka, Teiichi Sugiura
This study aimed to develop a predictive score for intrahepatic cholangiocarcinoma (ICC) in patients without lymph node metastasis (LNM) using preoperative factors. A retrospective analysis of 113 ICC patients who underwent liver resection with systemic lymph node dissection between 2002 and 2021 was conducted. A multivariate logistic regression analysis was used as a predictive scoring system for
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Assessing the long-term priorities of pancreaticoduodenectomy survivors HPB (IF 2.9) Pub Date : 2024-02-27 Edward A. Joseph, Kara D. Bowers, Rebecca Marcus, Bibek Aryal, Suzanne C. Schiffman, Patrick L. Wagner, Sricharan Chalikonda, David L. Bartlett, Casey J. Allen
This study assessed the long-term quality of life (QOL) and priorities of pancreaticoduodenectomy (PD) survivors. Survivors were surveyed via internet-based support groups. The relative importance of longevity, experience, costs, and QOL were assessed. The PD cohort (n = 247, 35%) was 60 ± 12 years, 71% female, and 93% white. With moderate agreement, patients ranked survival most important, followed
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Novel multiparametric MRI detects improved future liver remnant quality post-dual vein embolization HPB (IF 2.9) Pub Date : 2024-02-13 Senthil Sundaravadanan, Fenella KS. Welsh, Pulkit Sethi, Shaheen Noorani, Ben A. Cresswell, John J. Connell, Sina K. Knapp, Luis Núñez, J. Michael Brady, Rajarshi Banerjee, Myrddin Rees
Optimisation of the future liver remnant (FLR) is crucial to outcomes of extended liver resections. This study aimed to assess the quality of the FLR before and after dual vein embolization (DVE) by quantitative multiparametric MRI. Of 100 patients with liver metastases recruited in a clinical trial (Precision1:NCT04597710), ten consecutive patients with insufficient FLR underwent quantitative multiparametric
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Experts vs. machine – comparison of machine learning to expert-informed prediction of outcome after major liver surgery HPB (IF 2.9) Pub Date : 2024-02-13 Roxane D. Staiger, Tarun Mehra, Sarah R. Haile, Anja Domenghino, Christoph Kuemmerli, Fariba Abbassi, Damian Kozbur, Philipp Dutkowski, Milo A. Puhan, Pierre-Alain Clavien
Machine learning (ML) has been successfully implemented for classification tasks (e.g., cancer diagnosis). ML performance for more challenging predictions is largely unexplored. This study's objective was to compare machine learning vs. expert-informed predictions for surgical outcome in patients undergoing major liver surgery. Single tertiary center data on preoperative parameters and postoperative
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A preoperative risk score based on early recurrence for estimating outcomes after resection of hepatocellular carcinoma in the non-cirrhotic liver HPB (IF 2.9) Pub Date : 2024-02-13 Eloy Ruiz, Jorge Honles, Ramiro Fernández, Karla Uribe, Juan P. Cerapio, Karina Cancino, Juan Contreras-Mancilla, Sandro Casavilca-Zambrano, Francisco Berrospi, Pascal Pineau, Stéphane Bertani
Liver resection is the mainstay treatment option for patients with hepatocellular carcinoma in the non-cirrhotic liver (NCL-HCC), but almost half of these patients will experience a recurrence within five years of surgery. Therefore, we aimed to develop a rationale-based risk evaluation tool to assist surgeons in recurrence-related treatment planning for NCL-HCC. We analyzed single-center data from
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A new scoring system for predicting the outcome of hepatocellular carcinoma patients without microvascular invasion-a large-scale multicentre study HPB (IF 2.9) Pub Date : 2024-02-13 Ju-Xian Sun, Zhe Yang, Jia-Yi Wu, Jie Shi, Hong-Ming Yu, Mao-Lin Yan, Shu-Sen Zheng, Shu-Qun Cheng
The prognosis of HCC patients without MVI (so called M0) is highly heterogeneous and the need for adjuvant therapy is still controversial. Patients with HCC with M0 who underwent liver resection (LR) or liver transplantation (LT) as an initial therapy were included. The Eastern Hepatobiliary Surgery Hospital (EHBH)-M0 score was developed from a retrospective cohort to form the training cohort. The
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Effect of severe thrombocytopenia on bleeding in chronic liver disease after low risk surgical procedures: a meta-analysis HPB (IF 2.9) Pub Date : 2024-02-13 Lorenzo Loffredo, Enrico Maggio, Anna Rita Vestri, Arianna Di Rocco, Pasquale Pignatelli, Francesco Violi
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Evidence for molecular subtyping in pancreatic ductal adenocarcinoma: a systematic review HPB (IF 2.9) Pub Date : 2024-02-10 Francis P. Robertson, Andrew Cameron, Harry Speirs, Nejo Joseph, Ellie Taylor, Bathiya Ratnayake, Nigel B. Jamieson, Sanjay Pandanaboyana
Pancreatic Ductal Adenocarcinoma (PDAC) patients exhibit varied responses to multimodal therapy. RNA gene sequencing has unravelled distinct tumour biology subtypes, forming the focus of this review exploring its impact on survival outcomes. A systematic search across PubMed, Medline, Embase, and CINAHL databases targeted studies assessing long-term overall and disease-free survival in PDAC patients
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Preoperative pancreatic radiologic characteristics predict pancreatic-specific complications before pancreaticoduodenectomy: the pancreatic acinar radiologic score HPB (IF 2.9) Pub Date : 2024-02-09 Pietro Addeo, Pierre de Marini, Gerlinde Averous, Arnaud Trog, Pierre de Mathelin, Stefano Gussago, Laura Fiore, Lucas Geyer, Vincent Noblet, Philippe Bachellier
High acinar pancreatic contents are associated with a higher rate of postoperative pancreatitis (PAP) and pancreatic fistula formation (POPF). Predicting acinar contents preoperatively might identify those at high risk of developing postoperative complications. A multivariable analysis was performed to identify radiological factors associated with high pancreatic acinar content at histology in patients
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Addressing Long-Term Mortality Risk in Patients Undergoing Total Pancreatectomy with Islet Autotransplant (TPIAT): Causes of Death and Risk Factors HPB (IF 2.9) Pub Date : 2024-02-09 Gregory Hooks, Han Lu, Anne Eaton, Guru Trikudanathan, Elissa Downs, Martin L. Freeman, Sarah J. Schwarzenberg, Timothy L. Pruett, Srinath Chinnakotla, Karthik Ramanathan, Gregory J. Beilman, Melena D. Bellin
Total pancreatectomy with islet autotransplant (TPIAT) can improve quality of life for individuals with pancreatitis but creates health risks including diabetes, exocrine insufficiency, altered intestinal anatomy and function, and asplenia. We studied survival and causes of death for 693 patients who underwent TPIAT between 2001 and 2020, using the National Death Index with medical records to ascertain
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Letter to the editor: Minimally invasive versus open radical antegrade modular pancreatosplenectomy for pancreatic ductal adenocarcinoma: an entropy balancing analysis HPB (IF 2.9) Pub Date : 2024-02-09 Sree Subramaniyan S, Bishal Pal, Sowmiya Velusamy, Mannoj K. Shanmugam, Debasis Naik, Shnamugam Dasarathan, Vishnu Prasad Nelamangala Ramakrishnaiah
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Comparison of tumor response and outcomes of patients with hepatocellular carcinoma after multimodal treatment including immune checkpoint inhibitors – a systematic review and meta-analysis HPB (IF 2.9) Pub Date : 2024-02-09 Zaiba S. Dawood, Zachary J. Brown, Laura Alaimo, Henrique A. Lima, Chanza Shaikh, Erryk S. Katayama, Muhammad M. Munir, Zorays Moazzam, Yutaka Endo, Selamawit Woldesenbet, Timothy M. Pawlik
The efficacy of immune checkpoint inhibitors (ICIs) combined with tyrosine kinase inhibitors (TKIs), trans-arterial chemoembolization (TACE), and radiotherapy to treat hepatocellular carcinoma (HCC) has not been well-defined. We performed a meta-analysis to characterized tumor response and survival associated with multimodal treatment of HCC. PubMed, Embase, Medline, Scopus, and CINAHL databases were
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Can preoperative Carbohydrate Antigen 19-9 predict metastatic pancreatic cancer? Results of a systematic review and meta-analysis HPB (IF 2.9) Pub Date : 2024-02-02 Syed S. Raza, Hala Khan, Shahab Hajibandeh, Shahin Hajibandeh, David Bartlett, Nikolaos Chatzizacharias, Keith Roberts, Ravi Marudanayagam, Robert P. Sutcliffe
To investigate the relationship between preoperative Carbohydrate Antigen 19-9 (CA 19-9) value and pancreatic cancer occult metastasis, and to determine the most sensitive and specific cut-off value of CA 19-9 for prediction of metastasis. A systematic search of MEDLINE, CENTRAL and Web of Science and bibliographic reference lists were conducted. All comparative observational studies that investigated
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European fellowship training opportunities for hepato-pancreato-biliary surgery: an international survey of fellows and program directors HPB (IF 2.9) Pub Date : 2024-02-02 Giampaolo Perri, Ajith K. Siriwardena, Stefan Gilg, Ernesto Sparrelid
There are no established training pathways for hepato-pancreato-biliary (HPB) surgery in Europe. This study aims to overview the current status of fellowship training from both fellows' and institutions' perspectives. A web-based snapshot survey was distributed to all members of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA) to reach for former fellows and program directors of
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Anatomical sectionectomy based on Takasaki's segmentation for solitary intrahepatic cholangiocarcinoma: a propensity-matched analysis HPB (IF 2.9) Pub Date : 2024-02-01 Wen-qiang Wang, Jian Li, Xing Lv, Jin-lin Wang, Er-lei Zhang, Bin-hao Zhang, Zhen-yu Xiao, Bin-yong Liang, Zhi-yong Huang
Anatomical sectionectomy based on Takasaki's segmentation has shown advantages in hepatocellular carcinoma. However, whether this approach improves the survival of intrahepatic cholangiocarcinoma (ICC) remains unknown. A series of 248 consecutive patients with solitary ICCs who underwent hepatectomy were studied retrospectively. The patients were classified into the groups of anatomical sectionectomy
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Local recurrence risk factors and outcomes in minimally invasive thermal ablation for liver tumors: a single-institution analysis HPB (IF 2.9) Pub Date : 2024-02-01 Roberto Montalti, Gianluca Cassese, Ahmed Zidan, Gianluca Rompianesi, Mariano Cesare Giglio, Silvia Campanile, Lorenza Arena, Marco Maione, Roberto I. Troisi
Minimally Invasive thermal ablation (MITA) of liver tumors is a commonly performed procedure. Despite being a first-option strategy for small lesions, it is technically demanding, and many concerns still exist about local recurrence. Consecutive patients undergoing MITA from 1 to 2019 to 12–2022 were retrospectively enrolled. Risk factors for local recurrence were investigated through univariate and
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A multicentre prospective evaluation of health-related quality of life and patient related outcomes in pancreatic and peripancreatic cancer: PROMCAN study HPB (IF 2.9) Pub Date : 2024-02-01 Nejo Joseph, Francis Robertson, James Lucocq, Rupaly Pande, Sarah Powell-Brett, Kate Swainston, Linda Sharp, Catherine Exley, Keith Roberts, Sanjay Pandanaboyana
The temporal evolution of HRQoL and the importance of other PROs to patients, following resection for pancreatic and peripancreatic malignancy remains unexplored. Patients undergoing pancreatic resection between 2021 and 2022 were enrolled from 2 UK HPB centres. Patients completed the EORTC QLQ-C30, QLQ-PAN26 tools and rated 56 PROs preoperatively (T1), at discharge (T2), 6-weeks (T3), 3-months (T4)
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Pan-European survey on current treatment strategies in patients with upfront resectable colorectal liver metastases HPB (IF 2.9) Pub Date : 2024-01-29 B.I. Kuiper, M. Abu Hilal, L.A. Aldrighetti, B. Björnsson, M. D’Hondt, C. Dopazo, A.A. Fretland, H. Isoniemi, J.P. Jonas, G. Kazemier, M. Lesurtel, J. Primrose, A. Schnitzbauer, T. Buffart, B. Gruenberger, R.J. Swijnenburg, T. Gruenberger
Background There is a lack of consensus on the definition of upfront resectability and use of perioperative systemic therapy for colorectal liver metastases (CRLM). This survey aimed to summarize the current treatment strategies for upfront resectable CRLM throughout Europe. Methods A survey was sent to all members of the European-African Hepato-Pancreato-Biliary Association to gain insight into the
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Splanchnic vein thrombosis in necrotizing pancreatitis: a post-hoc analysis of a nationwide prospective cohort HPB (IF 2.9) Pub Date : 2024-01-29 Noor J. Sissingh, Hester C. Timmerhuis, Jesse V. Groen, Mike J.P. de Jong, Marc G. Besselink, Bas Boekestijn, Thomas L. Bollen, Bert A. Bonsing, Stefan A.W. Bouwense, Wouter L. Hazen, Frederikus A. Klok, Hjalmar C. van Santvoort, Casper H.J. van Eijck, Robert C. Verdonk, J. Sven D. Mieog, Jeanin E. van Hooft
Background Treatment guidelines for splanchnic vein thrombosis in necrotizing pancreatitis are lacking due to a lack of data on the full clinical spectrum. Methods We performed a post-hoc analysis of a nationwide prospective necrotizing pancreatitis cohort. Multivariable analyses were used to identify risk factors and compare the clinical course of patients with and without SVT. Results SVT was detected
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Comparing Indications, Complexity and Outcomes of Laparoscopic Liver Resection Between Centers with and without a Liver Transplant Program: A French Nationwide Study HPB (IF 2.9) Pub Date : 2024-01-25 Sophie Laroche, Chetana Lim, Claire Goumard, Michel Rayar, Daniel Cherqui, Laurence Chiche, Louise Barbier, Ephrem Salamé, Jean-Yves Mabrut, Mickael Lesurtel, Stéphanie Truant, Emmanuel Boleslawski, Fabrice Muscari, Christian Hobeika, Mircea Chirica, Emmanuel Buc, Jean Hardwigsen, Astrid Herrero, Francis Navarro, François Faitot, David Patrice
BACKGROUND There are no data to evaluate the difference in populations and impact of centers with liver transplant programs in performing laparoscopic liver resection (LLR). METHODS This was a multicenter study including patients undergoing LLR for benign and malignant tumors at 27 French centers from 1996 to 2018. The main outcomes were postoperative severe morbidity and mortality. RESULTS A total
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Simple versus Radical Cholecystectomy and Survival for Pathologic Stage T1B Gallbladder Cancer HPB (IF 2.9) Pub Date : 2024-01-24 Kristen E. Rhodin, Stacy Goins, Ryan Kramer, Austin M. Eckhoff, Garth Herbert, Kevin N. Shah, Peter J. Allen, Daniel P. Nussbaum, Dan G. Blazer, Sabino Zani, Michael E. Lidsky
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PREOPERATIVE LIVER REGENERATION WITH CD133+ INFUSION IN PATIENTS WITH COLORECTAL LIVER METASTASES: PROOF-OF CONCEPT TRIAL HPB (IF 2.9) Pub Date : 2024-01-22 Alejandra García-Botella, Paz Martín, Ramiro Méndez, Luis Ortega, Jose Méndez, Javier Sastre, Luis Diez-Valladares, Antonio José Torres
Abstract not available
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Intraductal papillary neoplasms of the bile ducts: A comparative study of a rare disease in Europe and Nagoya, Japan HPB (IF 2.9) Pub Date : 2024-01-19 Núria Lluís, Shunsuke Onoe, Mario Serradilla-Martín, Mar Achalandabaso, Takashi Mizuno, François Jehaes, Bobby V.M. Dasari, Sara Mambrilla-Herrero, Ernesto Sparrelid, Anita Balakrishnan, Frederik J.H. Hoogwater, María João Amaral, Bodil Andersson, Frederik Berrevoet, Alexandre Doussot, Víctor López-López, Olivier Detry, Carlos Domingo-del Pozo, Nikolaos Machairas, Damján Pekli, José Manuel Ramia
Background Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB. Methods A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December
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Laparoscopic Anatomic vs. Nonanatomic Liver Resection for Large Hepatocellular Carcinoma (≥5 cm) in the Right Lobe HPB (IF 2.9) Pub Date : 2024-01-18 Ahmed Rashad Badawy, Ho-Seong Han, Tamer Mosaad El-Mahdy, Hossam Eldeen Mohamed Soliman, Mohammad Hamdy Abo-Ryia, Osama Helmy Elkhadrawy
Objective To determine the impacts and outcomes of laparoscopic anatomic liver resection (LAR) and laparoscopic nonanatomic resection (LNAR) in patients with large hepatocellular carcinoma (HCC) in the right lobe of the liver. Background There are few comparative studies of LAR and LNAR for large HCC. Method Three hundred thirty-seven patients underwent liver resection for large HCC (≥5 cm) at Seoul
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Exploring the clinical characteristics and prevalence of the annular pancreas: a meta-analysis HPB (IF 2.9) Pub Date : 2024-01-18 Dawid Plutecki, Patryk Ostrowski, Michał Bonczar, Weronika Michalik, Monika Konarska-Włosińska, Grzegorz Goncerz, Aleksiej Juszczak, Sanjib Kumar Ghosh, Krzysztof Balawender, Jerzy Walocha, Mateusz Koziej
Introduction The annular pancreas (AP) is a rare gastrointestinal congenital malformation, in which malrotation of the pancreatic ventral bud in the seventh week of embryonic development manifests in a partial or complete ring of tissue around the second part of the duodenum. Methods The main online medical databases such as PubMed, ScienceDirect, Wiley online library, Web of Science, and EBSCO discovery
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Letter to the Editor: Understanding Surgical Attrition for “Resectable” Pancreatic Cancer HPB (IF 2.9) Pub Date : 2024-01-08 Zachary J. Brown, Jordan M. Cloyd
Abstract not available
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Recurrent cholangitis in patients with a non-stenotic hepaticojejunostomy: incidence and risk factors HPB (IF 2.9) Pub Date : 2024-01-07 Anouk G. Overdevest, Jeska A. Fritzsche, Mark A.D. Smit, Marc G. Besselink, Alessandro M. Bonomi, Olivier R. Busch, Freek Daams, Otto M. van Delden, Geert Kazemier, Jesse Langver, Cyriel Y. Ponsioen, Rutger-Jan Swijnenburg, Roy L.J. van Wanrooij, Mattheus C.B. Wielenga, Babs M. Zonderhuis, IJsbrand A.J. Zijlstra, Joris I. Erdmann, Rogier P. Voermans
Introduction Cholangitis is a well-known complication after hepaticojejunostomy (HJ), which is mainly caused by a stenotic anastomosis. However, the rate of cholangitis in patients with a non-stenotic (i.e. patent) HJ is unknown. We aimed to evaluate the incidence and risk factors of recurrent cholangitis in patients with a non-stenotic HJ. Methods This single-center retrospective cohort study included
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The aMAP Score Predicts Long-Term Outcomes After Resection of Hepatocellular Carcinoma: A Multi-institutional Analysis HPB (IF 2.9) Pub Date : 2024-01-04 Diamantis I. Tsilimigras, Yutaka Endo, Francesca Ratti, Hugo P. Marques, François Cauchy, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Minoru Kitago, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Ana Gleisner, Feng Shen, Itaru Endo, Timothy M. Pawlik
Background The aMAP score is a proposed model to predict the development of hepatocellular carcinoma (HCC) among high-risk patients with chronic hepatitis. The role of the aMAP score to predict long-term survival among patients following resection of HCC has not been determined. Methods Patients undergoing resection for HCC between 2000-2020 were identified using a multi-institutional database. The
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Efficacy and perioperative safety of different future liver remnant modulation techniques: a systematic review and network meta-analysis HPB (IF 2.9) Pub Date : 2024-01-04 Emre Bozkurt, Jasper P. Sijberden, Meidai Kasai, Mohammad Abu Hilal
Background In daily clinical practice, different future liver remnant (FLR) modulation techniques are increasingly used to allow a liver resection in patients with insufficient FLR volume. This systematic review and network meta-analysis aims to compare the efficacy and perioperative safety of portal vein ligation (PVL), portal vein embolization(PVE), liver venous deprivation (LVD) and associating
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Impact of Cirrhosis, Severity of Cirrhosis and Portal Hypertension on the Outcomes of Minimally-invasive Left Lateral Sectionectomies for Primary Liver Malignancies HPB (IF 2.9) Pub Date : 2024-01-01 F.F. Coelho, P. Herman, J.A.P.K. Kruger, A.G.R. Wu, K.M. Chin, K.-H. Chen, L. Aldrighetti, B. Edwin, M. Abu Hilal, B.K.P. Goh
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Prediction of Post-hepatectomy Liver Failure: New Nomogram Based on Alanine Aminotransferase, Prothrombin Time Activity and Future Remnant Liver Proportion (APART Score) HPB (IF 2.9) Pub Date : 2024-01-01 Y. Takenaka, H. Maehira, H. Mori, N. Nitta, T. Maekawa, H. Ishikawa, K. Takebayashi, S. Kaida, T. Miyake, M. Tani
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Socioeconomic Variables in the National Cancer Database: Utilization and Impact of Income and Education in Survival Models for Patients with Resected Pancreas Cancer HPB (IF 2.9) Pub Date : 2023-12-22 Qianyun Luo, Christopher J. LaRocca, Jacob S. Ankeny, Eric H. Jensen, Schelomo Marmor, David G. Brauer
Abstract not available
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Pedicled ligament flaps during pancreatoduodenectomy are associated with reduced hemorrhage from hepatic artery and gastroduodenal artery stump during pancreatoduodenectomy: A systematic review, meta-analysis and trial sequential analysis. HPB (IF 2.9) Pub Date : 2023-12-21 Kuan Hang, Lijuan Wei, Mingchao Yi, Haoheng Liu, Yang Huang, Hao Zhang, Chunlu Tan, Kezhou Li, Junjie Xiong
Background The aim of this study was to investigate whether pedicled ligament flaps (PLF) covering around the hepatic and gastroduodenal artery stump can provide better clinical outcomes in pancreatoduodenectomy (PD). Methods We conducted a comprehensive search of databases (inception to January 2023) to identify studies comparing PD with or without PLF covering the skeletonized arteries. The perioperative
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Assessment of liver function by gadoxetic acid avidity in MRI in a model of rapid liver regeneration in rats HPB (IF 2.9) Pub Date : 2023-12-21 Jan Heil, Mark Augath, Vartan Kurtcuoglu, Joachim Hohmann, Wolf O. Bechstein, Pim Olthof, Andreas A. Schnitzbauer, Petra Seebeck, Marc Schiesser, Martin Schläpfer, Beatrice Beck-Schimmer, Erik Schadde
Background This animal study investigates the hypothesis of an immature liver growth following ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) by measuring liver volume and function using gadoxetic acid avidity in magnetic resonance imaging (MRI) in models of ALPPS, major liver resection (LR) and portal vein ligation (PVL). Methods Wistar rats were randomly allocated
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Utility of modified pancreaticoduodenectomy (Hi-cut PD) for middle-third cholangiocarcinoma: An alternative to hepatopancreaticoduodenectomy HPB (IF 2.9) Pub Date : 2023-12-20 Shunsuke Onoe, Takashi Mizuno, Nobuyuki Watanabe, Yukihiro Yokoyama, Tsuyoshi Igami, Junpei Yamaguchi, Masaki Sunagawa, Shoji Kawakatsu, Yoshie Shimoyama, Tomoki Ebata
Background The standard procedure for middle-third cholangiocarcinoma (MCC) is pancreaticoduodenectomy (PD); hepatopancreaticoduodenectomy (HPD) is often performed despite its high risk. There is no clear selection guidance for these procedures. Methods Patients with MCC who underwent HPD or PD were retrospectively evaluated. The conventional PD was modified (mPD) to transect the bile duct beyond or
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What would you do? A Survey of HPB Surgeons Practice Patterns HPB (IF 2.9) Pub Date : 2023-12-13 Ahmer Irfan, Wendy Feng, Katherine McElroy, Vikas Dudeja, Sushanth Reddy, J. Bart Rose
Introduction The surgical decision making for pancreatic adenocarcinoma is complex. Although practice guidelines exist for many scenarios, these do not cover many common eventualities that may be encountered during these cases. We sought to identify the practice pattern variations amongst pancreatic surgeons in response to commonly experienced clinical scenarios. Methods A multiple-choice questionnaire
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Safety and Feasibility of Establishing an Adjuvant Hepatic Artery Infusion Program HPB (IF 2.9) Pub Date : 2023-12-13 Lauren M. Janczewski, Rachel H. Joung, Amir A. Borhani, Robert J. Lewandowski, Yury S. Velichko, Mary F. Mulcahy, Devalingam Mahalingam, Jennifer Law, Caitlin Bowman, Rajesh N. Keswani, Vitaliy Y. Poylin, David J. Bentrem, Ryan P. Merkow
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The “double-fired” gastro-jejunostomy as a form of improved efficiency during Whipple procedure. HPB (IF 2.9) Pub Date : 2023-12-13 G. Fiorentini, A. Zironda, A. Fogliati, S. Warner, S. Cleary, R. Smoot, M. Truty, M. Kendrick, D. Nagorney, C. Thiels, P. Starlinger
Background Gastro-jejunostomy (GJ) after pylorus-resecting pancreatoduodenectomy (PD) is most commonly performed in a hand-sewn fashion. Intestinal stapled anastomosis are reported to be as effective as hand-sewn in terms of patency and risk of leakage in other indications. However, the use of a stapled gastro-jejunostomy hasn’t been fully assessed in PD. The aim of the present technical report is
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Predictors of Non-Home Discharge After Pancreatoduodenectomy in Patients Aged 80 Years and Above HPB (IF 2.9) Pub Date : 2023-12-12 Ritah R. Chumdermpadetsuk, Mateo Garland, J. Christopher Polanco-Santana, Mark P. Callery, Tara S. Kent
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Combining preoperative C-reactive protein values with the Tokyo Guidelines 2018 grading criteria can enhance the prediction of surgical difficulty in early laparoscopic cholecystectomy for acute cholecystitis. HPB (IF 2.9) Pub Date : 2023-12-12 Kohei Mishima, Yoshiki Fujiyama, Taiga Wakabayashi, Atsuko Tsutsui, Nobuhiko Okamoto, Jacques Marescaux, Yuko Kitagawa, Go Wakabayashi
Background Early laparoscopic cholecystectomy (ELC) is the standard treatment for acute cholecystitis (AC). However, predicting the difficulty of this procedure remains challenging. The present study aimed to develop an improved prediction model for surgical difficulty during ELC, surpassing the current Tokyo Guidelines 2018 (TG18) grading system. Methods We analyzed data from 201 consecutive patients
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Calcium channel blockers are associated with improved survival in pancreatic cancer patients undergoing neoadjuvant chemotherapy and resection HPB (IF 2.9) Pub Date : 2023-12-10 Zhi Ven Fong, George Severs, John Moir, Steve White, Motaz Qadan, Samuel Tingle
Background Repurposing existing drugs for use in oncology is more efficient, cost-effective and safe than novel drug discovery. Calcium signalling is increasingly recognised to have a key role in chemoresistance. This study aimed to assess the impact of calcium channel blockers (CCB) in pancreatic cancer. Methods Retrospective population study of patients undergoing resection of pancreatic ductal adenocarcinoma
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Single Center Experience Using Stereotactic Body Radiation Therapy (SBRT) on Orthotopic Liver Transplant Protocol for Unresectable Cholangiocarcinoma HPB (IF 2.9) Pub Date : 2023-12-10 Trudy C. Wu, Jie Deng, Fang-I Chu, Saeed Sadeghi, Richard Finn, Vatche G. Agopian, Percy Lee, Ann C. Raldow
Purpose To evaluate tolerability, pathologic response, and disease outcomes utilizing pre-operative stereotactic body radiation therapy (SBRT) followed by consolidation chemotherapy (CHT) prior to orthotopic liver transplant (OLT) in unresectable cholangiocarcinoma (CCA). Methods and Materials This was a retrospective chart review of patients treated on OLT protocol at a single tertiary center from
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Inadequacy of the eighth edition of the American Joint Committee on Cancer pancreatic cancer staging system for invasive carcinoma associated with premalignant lesions in the pancreas: an analysis using the National Cancer Database HPB (IF 2.9) Pub Date : 2023-11-30 Hye-Sol Jung, Mirang Lee, Youngmin Han, Alexander S. Thomas, Won-Gun Yun, Young Jae Cho, Michael D. Kluger, Jin-Young Jang, Wooil Kwon
Background Despite lacking evidence that they behave similarly, invasive carcinomas arising from premalignant lesions are currently staged by the same criteria as conventional pancreatic ductal adenocarcinoma. Methods Clinicopathologic information and survival data were extracted through a thorough search of histology codes from National Cancer Database (2006-2016). A total of 723 patients with invasive
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