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The Diagnostic Performance of Serum αvβ6 Autoantibodies for Ulcerative Colitis: A Systematic Review and Meta-Analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-16 Jiao Yang, M.M Cai Huang, M.M Jing-Wen Liang, M.M Yan-Chang Lei
Currently, there is no single golden standard for diagnosing ulcerative colitis (UC). Now serum αvβ6 autoantibodies have shown promise as a diagnostic tool for UC. Here the aim was to determine the diagnostic performance of serum αvβ6 autoantibodies for UC. PubMed, the Cochrane Library, the Embase, and the Web of Science were searched comprehensively. STATA software was utilized to analyze the relevant
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Independent and joint association of physical activity and adequate weekday sleep duration with metabolic dysfunction-associated steatotic liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-12 Yaxin Li, Yitian Guo, Shiyun Tan
The independent and joint association of physical activity (PA) and weekday sleep duration with metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. Aims: We intended to explore this association in the United States. This cross-sectional study recruited 4974 individuals from the National Health and Nutrition Examination Survey between 2017 and 2018. Information regarding
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A novel homozygous mutation, c.662_672del, in DGUOK gene causing mitochondrial DNA depletion syndrome of type hepatocerebral – A case report Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-11 Kandula Radhakrishna, Batchu Rajsekhar, K. V. Raja Ramesh, Neelima Chitturi, Sandhya Kiran Pemmasani, Anuradha Acharya
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Construction and validation of classification models for predicting the response to concurrent chemo-radiotherapy of patients with esophageal squamous cell carcinoma based on multi-omics data Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-11 Zhi-Mao Li, Wei Liu, Xu-Li Chen, Wen-Zhi Wu, Xiu-E. Xu, Man-Yu Chu, Shuai-Xia Yu, En-Min Li, He-Cheng Huang, Li-Yan Xu
Concurrent chemo-radiotherapy (CCRT) is the preferred non-surgical treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC). Unfortunately, some patients respond poorly, which leads to inappropriate or excessive treatment and affects patient survival. To accurately predict the response of ESCC patients to CCRT, we developed classification models based on the clinical,
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Safety and efficacy of dexmedetomidine vs. midazolam in complex gastrointestinal endoscopy: A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-10 Wei Liu, Xiaoyan Ge, Fang Gao, Qingfang Kan, Shaohua Wang, Yikai Wang, Chuan He
This study aims to perform a meta-analysis to evaluate the safety and efficacy of dexmedetomidine versus midazolam for complex digestive endoscopy procedures, with the goal of offering comprehensive clinical evidence. Following predefined inclusion criteria, five databases were systematically searched, with a focus on identifying randomized controlled trials (RCTs) that compared the administration
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Effectiveness of metformin for the reversal of cold-ischemia-induced damage in hepatosteatosis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-10 Mustafa Oruc, Mustafa Emre Gedik, Meral Uner, Elif Ulug, Reyhan Nergiz Unal, Gurcan Gunaydin, Ahmet Bulent Dogrul
Primary dysfunction and rejection are more common in donor liver tissues with steatosis. AMP-activated protein kinase (AMPK) assumes organ-protective functions during ischemia. Metformin was used for the activation of AMPK in hepatocytes. The aim of this study is to investigate the effectiveness of metformin administration for the reversal of cold-ischemia-induced damage in hepatosteatosis. Seven-week-old
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Acantholytic squamous cell carcinoma of the gallbladder: Report of a rare case with diagnostic challenges Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-07 Xiaolei Yue, Shi Cao, Yonglin Chen
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Efficacy and safety of drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with tyrosine kinase inhibitors (TKIs) in patients with unresectable hepatocellular carcinoma (uHCC): A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-05 Jun Ji, Zhihong Zhang, Ziqi Hou, Guoteng Qiu, Shizheng Mi, Zhaoxing Jin, Jiwei Huang
The optimal management of unresectable hepatocellular carcinoma (uHCC) remains an unresolved challenge. There is ongoing debate regarding the efficacy and safety of drug-eluting bead TACE (DEB-TACE) with tyrosine kinase inhibitors (TKIs). We searched PubMed, Embase, Web of Science and the Cochrane Library for eligible studies. The main endpoints under investigation were survival outcomes, including
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The impact of secondhand smoke on failure of Helicobacter pylori therapy is not inferior to that of smoking Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-29 Jiajia Wu, Zheng Qian, Dingfu Zhong, Min Lin
Previous studies have shown the associations between smoking and failure to eradicate Helicobacter pylori (H. pylori), but less is known about the impact of secondhand tobacco smoke (SHS) on H. pylori eradication. Between July 2022 to July 2023, 646 patients who received proton pump inhibitor (PPIs) as first-line H. pylori eradication therapy were recruited for the study. Information was obtained via
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Chronic gastrointestinal immune-related adverse events in patients exposed to immune checkpoint inhibitors Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-29 Marine Jeay, Franck Carbonnel, Caroline Robert, Charlotte Mussini, Christophe Bellanger, Antoine Meyer
Immune checkpoint inhibitors (ICI) cause acute gastrointestinal (GI) immune-related adverse events (IrAEs). We aimed to report and describe chronic GI IrAEs. We included consecutive patients addressed to a single center between October 2010 and March 2022 for endoscopic and/or histological GI inflammation persisting at least six months after the last dose of ICI. Among a total of 178 patients addressed
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Gastric adenocarcinoma of fundic gland (chief cell predominant) type Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-22 Dong-Ge Han, Ke Wang, Wei Liu
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Neuroendocrine tumor of the major duodenal papilla Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-18 Wei Liu, Dong-Ge Han, Lin Cheng
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Sodium taurocholate cotransporter polypeptide deficiency from two pairs of twins with homozygous and heterozygous of p.Ser267Phe variant, respectively: Case report Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-16 Meifen Wang, Tao Chen, Meirui Li, Rui Chen, Junchao Peng, Jiwei Li
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Efficacy and safety of precutting endoscopic mucosal resection versus endoscopic submucosal dissection for non-ampullary superficial duodenal lesions Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-16 Dawei Chen, Sunya Fu, Jianwei Shen
Endoscopic treatments for non-ampullary superficial duodenal lesions (NASDLs) are yet to be standardized. Endoscopic submucosal dissection (ESD) for NASDLs demands advanced techniques and a long procedure time to prevent perforation and bleeding. Precutting endoscopic mucosal resection (EMR) is a technical modification of ESD that overcomes the limitations of ESD. This study aimed to compare the efficacy
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Bilateral optic atrophy in Wilson disease: A case report and literature review Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Fei Chen, Chunli Chen, Yang Zhang, Libin Jiang, Zhiqin Huang, Fred K Chen
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The clinical manifestations of WD are complex and variable, with Kayser–Fleischer ring (K-F ring) and the sunflower cataract being the most common ocular findings. Visual impairment is rare in patients with WD. We report the case of a 17-year-old female with bilateral optic atrophy associated with WD and summarize the clinical
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Thermal ablation for hepatic tumors in high-risk locations Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Elijah Ndhlovu, Bi-Xiang Zhang, Xiao-Ping Chen, Peng Zhu
Thermal ablative techniques such as radiofrequency and microwave ablation are minimally invasive and cost-effective approaches that are currently being adopted as alternatives to surgical resection for primary and metastatic liver malignancies. However, they are considered to be relatively contraindicated for tumors in high-risk locations due to technical difficulties and a perceived increased risk
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Increased risk of colorectal adenomas with metabolic-associated fatty liver disease components Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Dongsheng Ran, ChunLing Xin, Yingcai Ma, Yanyan Lu
Metabolic (dysfunction)-associated fatty liver disease is the most common liver disease related to various metabolic disorders. Colorectal adenomas are related to metabolic dysregulation. Despite the proposed association between non-alcoholic fatty liver disease and colorectal adenomas, the influence of metabolic-associated fatty liver disease on colorectal adenomas has yet to be investigated. Our
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Computed tomography-guided percutaneous cryoablation and microwave ablation in the treatment of perivascular hepatocellular carcinoma: A comparative study with propensity score matching Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Bing Li, Zi Wang Ren, Chuan Zhang, Xiao Xuan Yu, Xiao Xue Xu, Yong Du, Han Feng Yang
To evaluate the safety and efficacy of cryoablation (CYA) and microwave ablation (MWA) in the treatment of patients with perivascular hepatocellular carcinoma (HCC). Patients with perivascular HCC who underwent computed tomography (CT)-guided percutaneous CYA or MVA treatment in our hospital from August 2009 to March 2019 were included. Propensity score matching (PSM) was performed to adjust for potential
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Social determinants of health influencing the adherence to post-endoscopic mucosal resection surveillance Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-13 Bijal Vashi, Dalton A. Norwood, Rebecca Sullivan, Yassmin Hegazy, Sergio A. Sánchez-Luna, Patricia Ajayi-Fox, Ali M. Ahmed, Kondal R. Kyanam Kabir Baig, Shajan Peter, Ramzi Mulki
: Colorectal cancer (CRC) is a global health challenge, particularly in Alabama, where the incidence rates exceed national averages. This study investigated the factors influencing adherence to post-endoscopic mucosal resection (EMR) colonoscopies, focusing on travel distance and socioeconomic status. This study aimed to provide evidence-based insights to improve patient care in CRC management. This
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Progress in the treatment and prevention of esophageal stenosis after endoscopic submucosal dissection Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-03 Yangyang Duan, Wenxiu Jia, Ying Liang, Xiuning Zhang, Zhufeng Yang, Qian Yang
The primary treatment for early esophageal cancer and precancerous lesions is endoscopic submucosal dissection (ESD). However, this approach leads to a high incidence of postoperative esophageal stenosis, which can significantly impact a patient's quality of life. While various methods are available to prevent post-ESD esophageal stenosis, their effectiveness varies. Therefore, this study aims to provide
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Clinical significance of ribosome production factor 2 homolog in hepatocellular carcinoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-01 Yan An, Yechen Xia, Zhengyang Wang, Guang-Zhi Jin, Mingyi Shang
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Dysregulation of ribosome biogenesis increases the risk of cancer. RPF2 (ribosome production factor 2 homolog), a member of the BRIX family, is involved in ribosome biogenesis. However, the biological functions of RPF2 in HCC remain unclear. This study aims to evaluate the function of RPF2 and its clinical significance
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Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-28 Thamiris Vaz Gago Prata, Victória Gonçalves de Paula, Lhays Ozório Passos, Vitória Luiza Batalhoti Brogiato, Gustavo Manoel Ferreira, Caroline Manchiero, Bianca Peixoto Dantas, Débora Bignotto Rosane Battaglia, Gerusa Maria Figueiredo, Fátima Mitiko Tengan, Mariana Cavalheiro Magri
Abstract not available
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Aspirin for non alcoholic fatty liver disease: Promising but inconclusive–A letter to the editor Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-23 Hafiz Muhammad Sohaib Hayat, Hamza Naeem
Abstract not available
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A comparison analysis of the somatic mutations in early-onset gastric cancer and traditional gastric cancer Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-20 Xiaoxuan Han, Xiaoxiao Jia, Chong sheng, Mengyuan Li, Jinxi Han, Kaijuan Wang
Background Early onset gastric cancer (EOGC) has been on the rise in recent years and differs slightly in pathology from traditional gastric cancer (TGC). Somatic mutations have an essential role in the development of gastric cancer. We aimed to investigate these two types of gastric cancers at the level of somatic mutations and to further understanding of gastric cancer development. Methods Somatic
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Post-colonoscopy colorectal cancer: A population-based cohort study of fecal occult blood test-positive colonoscopies Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-20 Bernard Denis, Alice Bertolaso, Isabelle Gendre, Philippe Perrin, Karima Hammas
Background Data on post-colonoscopy colorectal cancers (PCCRCs) after fecal occult blood test (FOBT)-positive colonoscopies is scarce (guaiac-based (gFOBT) or fecal immunochemical test (FIT)). Aims Evaluate the prevalence and characteristics of PCCRCs in the French gFOBT CRC screening program. Methods Retrospective population-based cohort study of all gFOBT-positive colonoscopies performed among individuals
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Association of composite dietary antioxidant index and muscle mass in individuals with metabolic associated fatty liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-15 Jing Guo, Lin Shi, Yan Sun
Background There is mounting evidence indicating the association between oxidative stress and the detrimental effect it poses on muscle mass. However, the crucial interplay between the Composite Dietary Antioxidant Index (CDAI), a key metric of antioxidant-rich diets, and the occurrence of muscle loss has remained largely unexplored. Hence, in this study, we aim to investigate the potential relationship
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Predicting cancer-specific mortality in T1/2 hepatocellular carcinoma after radiofrequency ablation by competing risk nomogram: A population-based analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-12 Qifan He, Yue Xiong, Pengcheng Xia, Xiaoyu Yang, Yihui Yu, Zhonghua Chen
Background Radiofrequency ablation (RFA) is one of the primary treatment methods for T1/2 hepatocellular carcinoma (HCC), but the risk factors after RFA remain controversial. This study aims to identify the key factors associated with cancer-specific mortality (CSM) in patients with T1/2 HCC after RFA using competing risk analysis and to establish a prognostic nomogram for improved clinical management
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A simple cap-assistant method to removal fishbone embedded in the cervical esophageal wall Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-11 Si-Di Wang, Ting-Ting Cao, Zhu Wang
Abstract not available
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Enhanced therapeutic outcomes with atezolizumab-bevacizumab and SIRT combination compared to SIRT alone in unresectable HCC: A promising approach for improved survival Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-06 Amel Mejait, Charles Roux, Marine Soret, Edouard Larrey, Mathilde Wagner, Jean Charles Bijot, Charlotte Lussey-Lepoutre, Dominique Thabut, Claire Goumard, Philippe Maksud, Manon Allaire
Background Integrating immunotherapy with locoregional therapies marks a significant milestone in the realm of hepatocellular carcinoma (HCC) treatment . This study aimed to assess the impact of addition of Atezolizumab-Bevacizumab (AtezoBev) on the outcome patients treated with SIRT. Methods We conducted a study that included all Child-Pugh A HCC treated with SIRT since 2017. We examined the effects
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Geriatric factors associated with overall survival in older patients with metastatic colorectal cancer Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-03 Véronique Dardaine, Mathilde Cancel, Kaggwa Inyambo, Julie Biogeau, Carine Sauger, Thierry Lecomte, Etienne Dorval
Advanced age in patients with colorectal cancer is a factor of poor prognosis, but little is known about geriatric factors associated with survival and chemotherapy prescription in frail elderly patients. Our research sought to investigate these factors in older patients with metastatic colorectal cancer (mCRC). Patients and methods patients aged ≥75 years, who were treated for mCRC and have had a
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Comparison between the effect of Empagliflozin and Pioglitazone added to metformin in patients with type 2 diabetes and nonalcoholic fatty liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-29 Laya Hooshmand Gharabagh, Ali Shargh, Mohammad Reza Mohammad Hosseini Azar, Ayda Esmaeili
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Bacteroides thetaiotaomicron and its inactivated bacteria ameliorate colitis by inhibiting macrophage activation Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-28 Sikong Yinhe, Li Lixiang, Li Yan, Gu Xiang, Li Yanqing, Zuo Xiuli
Background Studies have demonstrated that Bacteroides thetaiotaomicron (BT) has protective effect against colon inflammation in murine models. Macrophages play an important role in gut immunity. However, the specific mechanisms of BT on macrophage are still unelucidated. Thus, our study investigates the anti-inflammatory effect of BT and its heat-treated inactivated bacteria on experimental colitis
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Fecal Incontinence Subtype Assessment (FI-SA): Validation of a new tool to distinguish among subtypes of fecal incontinence Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-28 Audrey Julienne, Guillaume Gourcerol, Gérard Amarenco, Nicolas Turmel, Anne-Marie Leroi, Charlotte Desprez
Purpose Three subtypes of fecal incontinence (FI) are described in the literature: urge, mixed and passive FI, but the relevance of this classification remains unknown. To our knowledge, no questionnaire has been validated in a general population of patients with FI to classify patients between the different subtypes of FI. The aim of the present study was to validate the Fecal Incontinence Subtype
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Development and validation of a novel nomogram model to assess the risk of gastric contents in outpatients undergoing elective sedative gastrointestinal endoscopy procedures Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-28 Yuqing Yan, Yuzhan Jin, Yuanyuan Cao, Chen Chen, Xiuxiu Zhao, Huaming Xia, Libo Yan, Yanna Si, Jianjun Zou
Background Gastric contents may contribute to patients' aspiration during anesthesia. Ultrasound can accurately assess the risk of gastric contents in patients undergoing sedative gastrointestinal endoscopy (GIE) procedures, but its efficiency is limited. Therefore, developing an accurate and efficient model to predict gastric contents in outpatients undergoing elective sedative GIE procedures is greatly
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Population characteristics, healthcare pathways and outcomes of patients with cirrhosis hospitalized with overt hepatic encephalopathy in France: A study of the French Hospital‐Discharge Database Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-27 Dominique Thabut, Julia Roux, Philippe Sultanik, Cheikh Tamberou, Pierre-Louis Prost, Hervé Hagège
Hepatic encephalopathy (HE) is a severe complication of cirrhosis, independently associated with a poor survival. The objectives of this study were to describe the prevalence of overt hepatic encephalopathy (OHE) requiring hospitalization, and the healthcare pathways and outcomes of patients hospitalized for OHE in France. Data from the French Hospital‐Discharge Database (Programme de Medicalisation
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Metabolism-related signalling pathways involved in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-23 Cheng Xie, Kaiyu Liu, Yixin Xie, Shun Liu, Bai Ji
Metabolic dysfunction-associated steatotic liver disease (MASLD) which formerly known as non-alcoholic fatty liver disease (NAFLD) is one of the causes of liver cirrhosis. Currently, a growing number of liver cirrhosis cases develop on the basis of MASLD, and the pathogenesis of MASLD remains unclear. This paper reviews the research progress on the involvement of different metabolism-related signalling
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Gut dysbiosis in Crohn's disease: Never so close to solving the chicken-and-egg enigma: Commentary to “Gut microbiome composition is associated with future onset of Crohn's disease in healthy first-degree relatives, by Raygoza Garay JA et al., Gastroenterology 2023” Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-23 Nathan Grellier, Harry Sokol, Philippe Seksik
Crohn's disease (CD) is a chronic disease of the digestive tract whose pathogenesis remains not fully understood. Several studies have implicated the gut microbiota as a key player in the onset of gut inflammation. However, most of the data is based on case-control studies comparing patients with established disease with controls, usually healthy individuals. The study by Raygoza Garay and colleagues
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The regulatory effect of lncRNA LINC00943 on the progression of hepatocellular carcinoma and its relationship with clinicopathological features Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-23 Xiaoan Qi, Liang Liu
Background The risk factors for the pathogenesis of HCC are highly variable, and the prognosis of patients is very unsatisfactory. In this study, we investigated the regulatory effect of LINC00943 on HCC progression and its relationship with clinicopathological features. Methods LINC00943 level in HCC tissues and cell specimens was verified by RT-qPCR. The pathologic significance of LINC00943 in the
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Reply to “Epidemiology, treatment and burden of Wilson disease in France: A 10-year analysis of the National health insurance database” Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-14 Mickael Alexandre Obadia, France Woimant, Philippe Tuppin, Dominique Debray, Aurelia Poujois
Abstract not available
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Good outcome of liver transplantation in patients with pre-existing renal cell carcinoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-13 G. Lassailly, M. Ningarhari, J. Dumortier, C. Lafforgue, S. Bouye, M.El Amrani, G. Lebuffe, A. Villers, S Truant, P. Mathurin, A. Louvet, O Boillot, E Boleslawski, S. Dharancy
The presence of a pre-existing or recent extra-hepatic solid tumor was considered for a long time as an absolute contraindication to liver transplantation, by fear of futility with an unacceptable increase in non-liver-related mortality. However, cancer-related mortality in solid malignancies is heterogeneous, and experts suggest that case-by-case multidisciplinary decisions should be made. Here, we
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Cardiovascular outcomes post bariatric surgery in patients with metabolic dysfunction-associated steatotic liver disease - A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-07 Jai Kumar, Sana Mohsin, Misha Hasan, Abdur Raheem Bilal, Kumail Mustafa Ali, Ahmed Umer, Dua Zehra Mohammad Hadi, Sanjna Nandlal, Sarwan Kumar
Background Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is linked with an increased risk of adverse cardiovascular events. Studies have suggested an association between the reduction of incident cardiovascular events in patients with MASLD after bariatric surgery. This systematic review and meta-analysis were performed
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Paneth cell: The missing link between obesity, MASH and portal hypertension Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-07 Minu Sajeev Kumar
Obesity is a global health crisis, with its prevalence steadily rising over the past few decades. One concerning consequence of obesity is its association with metabolic associated steatohepatitis [MASH], portal hypertension and liver cirrhosis. Cirrhosis is irreversible, but stages of liver disease before the development of cirrhosis are reversible with appropriate interventions. Studies have brought
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Clinicopathological characteristics of crawling-type gastric adenocarcinoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-07 Yongwei Xu, Yan Song, Bacui Zhang, Yusheng Yang, Jing Wang
Abstract not available
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Sustained response and HBsAg loss after nucleo(s)tide analogue discontinuation in chronic hepatitis B patients: the prospective SNAP study Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-06 Sylvia M. Brakenhoff, Mark Claassen, Pieter Honkoop, Robert J. de Knegt, Annemiek A. van der Eijk, André Boonstra, Robert A. de Man, Milan J. Sonneveld
Background & Aim(s) Current guidelines suggest that nucleos(t)ide analogues (NA) can be discontinued before HBsAg loss in a selected group of chronic hepatitis B (CHB) patients. We aimed to study the safety and off-treatment response after NA cessation. Methods This is a prospective, multicentre, cohort study in which eligible patients discontinued NA therapy. Adult patients, with a CHB mono-infection
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Exercise intensity impacts the improvement of metabolic dysfunction-associated steatotic liver disease via variations of monoacylglycerol O-acyltransferase 1 expression Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-06 Kyung-Wan Baek, Jong-Hwa Won, Ying-Ying Xiang, Dong Kyun Woo, Yoonjung Park, Ji-Seok Kim
Background The involvement of monoacylglycerol O-acyltransferase 1 (MOGAT1) in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) has been recognized. While exercise is recommended for the improvement of obesity and MASLD, the impact of exercise intensity remains unclear. This study aimed to examine the influence of exercise intensity on MOGAT1 expression in high-fat
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Primary gastrointestinal follicular lymphoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-30 Xiao-Mei Liu, Zhong Xu, Hai-Xing Wang, Wei-Feng Huang
Abstract not available
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Extensive cortical and thalamic FLAIR hypersignals in a patient with suspected hepatic encephalopathy Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-03 Margaux Cheval, Marjorie Latrasse, Stéphane Tran Ba, Guillaume Robbe
Abstract not available
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Clinical factors associated with illness perception, worry and mental health in sclerosing cholangitis: A single centre prospective study Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-24 Jeremy S. Nayagam, Wafaa Ahmed, Matthew Farrant, Jamie Jefferies, Vanessa Boshell, Anna Simpson, Deepak Joshi
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Xanthoma striatum palmare: Getting a handle on hyperlipidaemia in primary biliary cholangitis. Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-27 Fiona Sexton, William Shanahan, John D Ryan
Abstract not available
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Indigo naturalis (Qing dai) for inflammatory bowel disease: A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-23 Rinkalben Kakdiya, Daya Krishna Jha, Arup Choudhury, Anuraag Jena, Vishal Sharma
Background Indigo naturalis (Qing dai) is a traditional therapy reported to be useful in inflammatory bowel disease (IBD), especially for ulcerative colitis. We performed a systematic review of its efficacy and safety in IBD. Methods Electronic databases (Pubmed, Embase, and Scopus) were searched on 4th March 2023 to identify reports about the use of indigo naturalis in IBD. We extracted data with
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Gastric microbiota in patients with gastric MALT lymphoma according to Helicobacter pylori infection Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-18 Antoine Martin, Marine Jauvain, Emma Bergsten, Vanessa Demontant, Philippe Lehours, Caroline Barau, Michael Levy, Christophe Rodriguez, Iradj Sobhani, Aurelien Amiot
Background Gastric Mucosa Associated Lymphoid Tissue lymphoma (GML) development is triggered by Helicobacter pylori (H. pylori) infection. Little is known about the impact of H. pylori infection on gastric microbiota. Methods The gastric microbiota was retrospectively investigated using 16S rRNA gene sequencing in 32 patients with untreated GML (10 H. pylori-positive and 22 H. pylori-negative), 23
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An unusual endoscopic appearance of mantle cell lymphoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-17 Xiao-Mei Liu, Yi Ding, Wei-Feng Huang
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Glutamine synthetase and hepatocellular carcinoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-16 Jinghua Jiang, Yiting Hu, Dazhang Fang, JianSheng Luo
Glutamine synthetase (GS) is an enzyme that converts ammonia and glutamate to glutamine using adenosine triphosphate. GS is expressed in the brain, kidney, and liver tissues under normal physiological conditions. GS is involved in abnormal lipid metabolism of the liver by catalyzing de novo synthesis of glutamine, thereby inducing liver inflammation. Metabolic dysfunction-associated steatotic liver
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Focal loss of mural stratification as a radiological predictor for small bowel adenocarcinoma in Crohn's disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-13 Mathieu Uzzan, Victoria Assouline, Edouard Chambenois, Marjan Djabbari, Lionel Arrive, Cécile Charpy, Alain Luciani, Iradj Sobhani, Aymeric Becq, Laurent Beaugerie, Magali Svrcek, Julien Kirchgesner
Patients with Crohn's disease (CD) are at higher risk of small bowel adenocarcinoma (SBA). We aimed to identify radiological predictors of SBA in CD. We conducted a retrospective case-control study at two tertiary inflammatory bowel disease centers and identified CD patients diagnosed with SBA between 2003 and 2019. Patients were matched with up to four controls. Pre-operative imaging (magnetic resonance
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New developments and standard of care in the management of advanced gastric cancer Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-11 Léonard Depotte, Juliette Palle, Cosimo Rasola, Chloé Broudin, Vlad-Adrian Afrăsânie, Antoine Mariani, Aziz Zaanan
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Clinicopathological features of a rare cancer: Intrahepatic lymphoepithelioma-like cholangiocarcinoma with Epstein-Barr virus infection Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-11-07 Lingnan Zheng, Nan Zhou, Xi Yang, Yuanfeng Wei, Cheng Yi, Hongfeng Gou
Epstein-Barr virus-related lymphoepithelioma-like cholangiocarcinoma (EBV-LELCC), a subtype of intrahepatic cholangiocarcinoma (IHCC), is an extremely rare cancer. To date, only few cases have been reported. Therefore, more studies are needed to provide new insights into its clinicopathological characteristics and treatment. We retrospectively collected data from 16 EBV-LELCC patients admitted to our