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Perinatal asphyxia impact on networks of cortical activity Pediatr. Res. (IF 3.6) Pub Date : 2024-03-18 Srinivas Kota, Lina Chalak
The study by Syvälahti et al.1 demonstrates that EEG connectivity provides valuable insights into the brain’s electrical activity and connectivity patterns in hypoxic-ischemic brain injury. In this study, the severity of brain injury within the first day of life categorized infants with perinatal asphyxia into three subgroups: 29 without HIE (PA), 10 with mild HIE (HIE1), and 12 with moderate HIE (HIE2)
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Artificial intelligence to classify acquired intestinal injury in preterm neonates—a new perspective Pediatr. Res. (IF 3.6) Pub Date : 2024-03-18 Alain Cuna, Muralidhar H. Premkumar, Venkatesh Sampath
The last two decades have seen striking advances in our understanding of necrotizing enterocolitis (NEC) including the role of innate immune signaling in NEC and distinguishing NEC from other intestinal injury phenotypes such as spontaneous intestinal perforation (SIP).1,2,3 Nevertheless, it is recognized that NEC is a potpourri of several intestinal injury phenotypes that affect preterm and term infants
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Effects of postnatal corticosteroids on lung development in newborn animals. A systematic review Pediatr. Res. (IF 3.6) Pub Date : 2024-03-16 Irene M. Lok, Kimberley E. Wever, Roos J. S. Vliegenthart, Wes Onland, Anton H. van Kaam, Minke van Tuyl
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Aerobic physical capacity and health-related quality of life in children with sickle cell disease Pediatr. Res. (IF 3.6) Pub Date : 2024-03-15 Corentin Laurent-Lacroix, Marie Vincenti, Stefan Matecki, Perrine Mahé, Lionel Moulis, Gregoire De La Villeon, Sophie Guillaumont, Anne Requirand, Johan Moreau, Muriel Lalande, Marie-Christine Picot, Pascal Amedro, Arthur Gavotto
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Epigenetic associations in HPA axis genes related to bronchopulmonary dysplasia and antenatal steroids Pediatr. Res. (IF 3.6) Pub Date : 2024-03-13 Kenyaita M. Hodge, Vasyl Zhabotynsky, Amber A. Burt, Brian S. Carter, Rebecca C. Fry, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, Barry M. Lester, Carmen J. Marsit, T. Michael O’Shea, Todd M. Everson
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New insights and potential biomarkers for intraventricular hemorrhage in extremely premature infant, case-control study Pediatr. Res. (IF 3.6) Pub Date : 2024-03-11 Franklin Ducatez, Abdellah Tebani, Lenaig Abily-Donval, Sarah Snanoudj, Carine Pilon, Thomas Plichet, Charlotte Le Chatelier, Soumeya Bekri, Stéphane Marret
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Editor’s Focus Pediatr. Res. (IF 3.6) Pub Date : 2024-03-07
Congratulations to Paris Papagianis, the Early Career Investigator for March 2024. Dr. Papagianis is a postdoctoral research fellow at Monash University in Australia. Her research focuses on lung health and disease, spanning early life and adulthood with a translational lens. In her ECI Biocommentary, Dr. Papagianis discusses the importance of mentorship for career development, particularly mentorship
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Understanding the multidimensional neurodevelopmental outcomes in children after congenital Zika virus exposure Pediatr. Res. (IF 3.6) Pub Date : 2024-03-04 Sarah B. Mulkey, Meagan E. Williams, Colleen Peyton, Margarita Arroyave-Wessel, Madison M. Berl, Carlos Cure, Michael E. Msall
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Association between patent ductus arteriosus flow and home oxygen therapy in extremely preterm infants Pediatr. Res. (IF 3.6) Pub Date : 2024-03-07 Jana Termerova, Ales A. Kubena, Karel Liska, Viktor Tomek, Richard Plavka
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Publication Recommendations to Report Laboratory Data of Neonates – a Modified Delphi Approach Pediatr. Res. (IF 3.6) Pub Date : 2024-03-06 Zoë Vander Elst, Heidrun Hildebrand, Mary A. Short, Nick Henscheid, Robert Ward, Ronald Ariagno, Thomas Diacovo, Tim Lang, Karel Allegaert, Anne Smits
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Grieving lost selves: Throop’s concept of presencing forth of an absence Pediatr. Res. (IF 3.6) Pub Date : 2024-03-05 Kathy A. Riley
Impact This article expands on C.J. Throop’s concept of “presencing forth of an absence” introduced in his 2010 article “Latitudes of loss: on the vicissitudes of empathy,” applying it to elucidate personal stories of grief, including an experience of the ambiguous loss of a child. The author provides a novel framework for the intersubjective experience of the grieving person. The author offers pediatric
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Increased mortality in infants with abnormal T-cell receptor excision circles Pediatr. Res. (IF 3.6) Pub Date : 2024-03-05 Jenny Huang, Ashwin Shankar, Isabel Hurden, Ronald Thomas, Joseph Hill, Divya Seth, Elizabeth Secord, Pavadee Poowuttikul
Background T-Cell Receptor Excision Circles based newborn screening (TREC-NBS) allows for early detection of T-cell lymphopenia in infants with primary immunodeficiency disorders (PIDD). The utility of abnormal TREC-NBS in infants without PIDD is not well studied. We sought to evaluate the association of abnormal TREC-NBS with mortality. Methods 365,207 TREC-NBS from October 2011 to December 2014 were
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Temperature probe placement in very preterm infants during delivery room stabilization: an open-label randomized trial Pediatr. Res. (IF 3.6) Pub Date : 2024-03-05 Pranav R. Jani, Rajesh Maheshwari, Hannah Skelton, Patricia Viola, Sheela Thomas, Lynette Ryder, Mihaela Culcer, Umesh Mishra, Swapnil Shah, Jane Baird, James Elhindi, Ann-Maree Padernia, Traci-Anne Goyen, Daphne D’Cruz, Melissa Luig, Dharmesh Shah
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Balancing pediatric device utility and harm: navigating the challenges for safer healthcare Pediatr. Res. (IF 3.6) Pub Date : 2024-03-05 Facundo Jorro-Barón, Pedro Taffarel
Abstract This article discusses the challenges in balancing the utility and harm associated with pediatric medical devices. Takashima et al. explored the prevalence and complications of invasive devices across three Australian pediatric tertiary hospitals and reported a high prevalence of complications, particularly with vascular access devices. We also highlight the need to pay attention to the use
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Global, regional, and national burden of type 1 diabetes in adolescents and young adults Pediatr. Res. (IF 3.6) Pub Date : 2024-03-05 Boshen Gong, Wanyu Yang, Yumin Xing, Yaxin Lai, Zhongyan Shan
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Waist-circumference-to-height-ratio had better longitudinal agreement with DEXA-measured fat mass than BMI in 7237 children Pediatr. Res. (IF 3.6) Pub Date : 2024-03-05 Andrew O. Agbaje
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Science and policy in the Third Reich: a commentary on history and current relevance Pediatr. Res. (IF 3.6) Pub Date : 2024-03-04 Michael Shevell
The readership of this journal, comprising pediatric clinicians and child health investigators, collectively put their faith in the objectivity of science. The process of the scientific method yields ‘facts’ that are proven and rigorous beyond dispute. Being factual they are importantly also accepted as value-neutral. These facts are then applied in the clinic to inform the desired practice of evidence-based
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Trauma and warfare and clinicians’ role Pediatr. Res. (IF 3.6) Pub Date : 2024-03-04 Fiona McNicholas, Aoife Twohig
The evidence base for the wide ranging and long-lasting impact from adverse childhood experiences (ACEs) has grown exponentially. The initial study by Felitti et al., found a dose response relationship between childhood exposure to abuse/neglect (physical, sexual, or emotional) or household dysfunction (parental separation, domestic violence, or parental mental illness) and later adult morbidity and
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Less common phenotypes of myelin oligodendrocyte glycoprotein antibody-related diseases in children deserve more attention Pediatr. Res. (IF 3.6) Pub Date : 2024-03-04 Xiao-yu Wang, Yan Jiang, Peng Wu, Jian-nan Ma, Ping Yuan, Xiu-juan Li, Li Jiang
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Brain structural changes and molecular analyses in children with benign epilepsy with centrotemporal spikes Pediatr. Res. (IF 3.6) Pub Date : 2024-03-02 Heng Liu, Duoli Chen, Chengxiang Liu, Peng Liu, Hua Yang, Hong Lu
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Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm Pediatr. Res. (IF 3.6) Pub Date : 2024-03-04 Keia Sanderson, Russell Griffin, Nekayla Anderson, Andrew M. South, Jonathan R. Swanson, Michael Zappitelli, Heidi J. Steflik, Marissa J. DeFreitas, Jennifer Charlton, David Askenazi
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Effects of hemodynamic alterations and oxygen saturation on cerebral perfusion in congenital heart disease Pediatr. Res. (IF 3.6) Pub Date : 2024-03-04 Alexandra De Silvestro, Giancarlo Natalucci, Maria Feldmann, Cornelia Hagmann, Thi Dao Nguyen, Seline Coraj, Andras Jakab, Raimund Kottke, Beatrice Latal, Walter Knirsch, Ruth Tuura
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Prenatal mental health and emotional experiences during the pandemic: associations with infant neurodevelopment screening results Pediatr. Res. (IF 3.6) Pub Date : 2024-03-02 Cindy H. Liu, Amanda Koire, Candice Ma, Leena Mittal, Joshua L. Roffman, Carmina Erdei
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Association of Traditional dietary pattern with early and precocious puberty: a population-based cross-sectional study Pediatr. Res. (IF 3.6) Pub Date : 2024-03-02 Xinlin Chen, Simao Fu, Chaojun Chen, Yawen Yuan, Zhibin Dai, Ang Chen, Bihong Zhang, Shijian Liu, Cuilan Lin
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Caffeine pharmacokinetics following umbilical vein injection during delayed cord clamping in preterm lambs Pediatr. Res. (IF 3.6) Pub Date : 2024-03-01 Lida Zeinali, Evan Giusto, Heather Knych, Amy Lesneski, Houssam Joudi, Morgan Hardie, Deepika Sankaran, Satyan Lakshminrusimha, Payam Vali
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Eutectic mixture of local anesthetics and amethocaine as topical anesthetics in pediatrics: a meta-analysis Pediatr. Res. (IF 3.6) Pub Date : 2024-03-01 Kathryn S. Varghese, Adham Ahmed, Dave M. Mathew, Peter J. Fusco, Mabel N. Abraham
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Lipoprotein(a) serum concentrations in children in relation to body mass index, age and sex Pediatr. Res. (IF 3.6) Pub Date : 2024-02-28 Paulina E. Stürzebecher, Konstantin L. Uttinger, Mandy Vogel, Maike Schlingmann, Uta Ceglarek, Berend Isermann, Wieland Kiess, Antje Körner, Ulrich Laufs
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Recombinant IGF-1/BP3 protects against intestinal injury in a neonatal mouse NEC model Pediatr. Res. (IF 3.6) Pub Date : 2024-02-28 Xiaocai Yan, Elizabeth Managlia, Galen Carey, Norman Barton, Xiao-Di Tan, Isabelle G. De Plaen
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Editor’s Focus Pediatr. Res. (IF 3.6) Pub Date : 2024-02-27
Congratulations to Daniel O’Reilly, the Early Career Investigator highlighted in February 2024. Daniel is an Irish Clinical Academic Training fellow in the Department of Neonatology at Rotunda Hospital in Dublin. He has been working on a project investigating platelet activation in the neonatal transition. This work recently brought him to the University of Rochester on a Fulbright Scholarship to better
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Reassessing acquired neonatal intestinal diseases using unsupervised machine learning Pediatr. Res. (IF 3.6) Pub Date : 2024-02-27 Daniel R. Gipson, Alan L. Chang, Allison C. Lure, Sonia A. Mehta, Taylor Gowen, Erin Shumans, David Stevenson, Diomel de la Cruz, Nima Aghaeepour, Josef Neu
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Nest positioning on motor development, sleep patterns, weight gain in preterm infants: systematic review Pediatr. Res. (IF 3.6) Pub Date : 2024-02-26 Mayara M. C. Carneiro, Simone N. S. Ribeiro, Natália A. Menegol, Rodrigo Okubo, Dayane Montemezzo, Luciana Sayuri Sanada
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Serum endocan, asymmetric dimethylarginine and lipid profile in children with familial Mediterranean fever Pediatr. Res. (IF 3.6) Pub Date : 2024-02-23 Rania S. El Zayat, Fahima M. Hassan, Noran T. Aboelkhair, Walaa F. Abdelhakeem, Ahmed S. Abo Hola
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ApoE: A new piece to the severe malaria puzzle Pediatr. Res. (IF 3.6) Pub Date : 2024-02-22 Emily M. Stucke, Jonathan G. Lawton, Mark A. Travassos
Apolipoprotein E (apoE), encoded by the APOE gene, is a protein found throughout the body that facilitates lipid transport, particularly in the blood and central nervous system, via binding to the low-density lipoprotein receptor.1 The three major isoforms of apoE - apoE2, apoE3, and apoE4 - differ by single amino acid substitutions at two sites; apoE3 is the most common isoform. The different APOE
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An egg a day keeps kernicterus away Pediatr. Res. (IF 3.6) Pub Date : 2024-02-24 Silvia Gazzin, Claudio Tiribelli
Neonatal hyperbilirubinemia is a common occurrence in newborns, and timely and effective management of severe neonatal hyperbilirubinemia (SNH) by phototherapy (PT), and more recently double PT, the current golden standard treatment for reducing total serum bilirubin (TSB), is crucial for avoiding childhood disability (kernicterus spectrum disorder - KSD), or even death (reviewed in1). Despite being
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Vasoactive peptides as biomarkers for the prediction of retinopathy of prematurity Pediatr. Res. (IF 3.6) Pub Date : 2024-02-24 Roland P. Neumann, Roland Gerull, Pascal W. Hasler, Sven Wellmann, Sven M. Schulzke
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Implications of neonatal absence of innate immune mediated NFκB/AP1 signaling in the murine liver Pediatr. Res. (IF 3.6) Pub Date : 2024-02-23 Maya R. Grayck, William C. McCarthy, Mack Solar, Natarajan Balasubramaniyan, Lijun Zheng, David J. Orlicky, Clyde J. Wright
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Early life exposure to SARS-CoV-2 and offspring neurodevelopment: detecting a non-linear relationship requires a complex approach Pediatr. Res. (IF 3.6) Pub Date : 2024-02-22 Sarah B. Mulkey, Gianluca Ursini
The spectrum of neurodevelopmental outcomes for children born during the COVID-19 pandemic with either antenatal exposure to maternal SARS-CoV-2 infection or early postnatal SARS-CoV-2 infection continues to be an area of uncertainty and of important ingoing investigations. Rebecca Jackson and colleagues conducted a systematic review to assess the impact of antenatal or neonatal exposure to SARS-CoV-2
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GJ Express: an improvement initiative to decrease sedation and anesthesia for gastrojejunostomy tube exchanges Pediatr. Res. (IF 3.6) Pub Date : 2024-02-22 Qianqian Ellie Cheng, Jan Schriefer, Tina Sosa, Sarah Haen, Samantha J. Ferguson, Alexander Clark, Christine Boerman, Carly Hochreiter, Megan E. Gabel, Arvid Yung, David E. Lee, Kate G. Ackerman
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Molecular events in brain bilirubin toxicity revisited Pediatr. Res. (IF 3.6) Pub Date : 2024-02-20 Silvia Gazzin, Cristina Bellarosa, Claudio Tiribelli
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Development and validation of thromboembolism diagnostic algorithms in children with cancer from real-world data Pediatr. Res. (IF 3.6) Pub Date : 2024-02-22 Uma Athale, Jacqueline Halton, Anastasia Gayowsky, Anthony K. C. Chan, Jason D. Pole
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Early postnatal nutrition and renal consequences in preterm infants Pediatr. Res. (IF 3.6) Pub Date : 2024-02-19 Silvia Iacobelli, Alexandre Lapillonne, Farid Boubred
Abstract Perinatal nutritional factors may lead to decreased nephron endowment, decreased kidney function, and long-term development of chronic kidney disease and non-communicable diseases. At the same time, optimal postnatal nutrition and catch-up growth are associated with better neurodevelopmental outcomes in preterm infants. Therefore, nutritional management of preterm infants is a major challenge
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Sample entropy correlates with intraventricular hemorrhage and mortality in premature infants early in life Pediatr. Res. (IF 3.6) Pub Date : 2024-02-16 Michael D. Scahill, Valerie Chock, Katherine Travis, Molly Lazarus, Eric Helfenbein, Melissa Scala
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Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation Pediatr. Res. (IF 3.6) Pub Date : 2024-02-17 Alida J. Dam-Vervloet, Claudia F. Morsink, Marleen E. Krommendijk, Ingrid M. Nijholt, Henrica L. M. van Straaten, Lieke Poot, Nienke Bosschaart
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Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis Pediatr. Res. (IF 3.6) Pub Date : 2024-02-17 Noah H. Hillman, Matthew W. Kemp, Emily Royse, Hayley Grzych, Haruo Usada, Hideyuki Ikeda, Yuki Takahashi, Tsukasa Takahashi, Alan H. Jobe, Erin Fee
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Approaches to protocol standardization and data harmonization in the ECHO-wide cohort study Pediatr. Res. (IF 3.6) Pub Date : 2024-02-16 Lisa P. Jacobson, Corette B. Parker, David Cella, Daniel K. Mroczek, Barry M. Lester
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The serum thioredoxin-1 levels are not associated with bronchopulmonary dysplasia and retinopathy of prematurity Pediatr. Res. (IF 3.6) Pub Date : 2024-02-16 Mitsuhiro Haga, Nobuhiko Nagano, Junichi Ozawa, Kosuke Tanaka, Naoyuki Miyahara, Takeshi Fujimoto, Kuniya Ishii, Fumihiko Namba
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The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits Pediatr. Res. (IF 3.6) Pub Date : 2024-02-14 Sophie J. E. Cramer, Janneke Dekker, Michelle K. Croughan, Katie L. Lee, Kelly J. Crossley, Erin V. McGillick, Tessa Martherus, Martha Thio, Megan J. Wallace, Marcus J. Kitchen, Stuart B. Hooper, Arjan B. te Pas
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Who is accountable for stopping racism in our children’s hospitals? Pediatr. Res. (IF 3.6) Pub Date : 2024-02-16 Michael DeBaun
What was surprising about Karvonen et al.’s publication?1 Very little was surprising for many of us who work in children’s hospitals. What is new and refreshing is seeing data that our personal experiences of bigotry and racism are not just anecdotes but clearly can provide disincentives to stay in such a working environment as a resident, fellow, or faculty. In this well-constructed single-center
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Congenital anomalies and predisposition to severe COVID-19 among pediatric patients in the United States Pediatr. Res. (IF 3.6) Pub Date : 2024-02-16 Laura F. Goodman, Peter T. Yu, Yigit Guner, Saeed Awan, Akhil Mohan, Kevin Ge, Mathew Chandy, Mario Sánchez, Louis Ehwerhemuepha
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Falls in oxygen saturations accompany electrographic seizures in term neonates: an observational study Pediatr. Res. (IF 3.6) Pub Date : 2024-02-16 David Wertheim, Anup C. Kage, Ivone Lancoma-Malcolm, Caroline Francia, Michael Yoong, Divyen K. Shah
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Effects of cannabidiol in post-stroke mood disorders in neonatal rats Pediatr. Res. (IF 3.6) Pub Date : 2024-02-15 María Villa, María Martínez-Vega, Laura Silva, Itziar Muneta-Arrate, Ana Gómez-Soria, Carolina Muguruza, Aarón del Pozo, María de Hoz-Rivera, Angela Romero, Luis F. Callado, Maria José Casarejos, José Martínez-Orgado
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Record, reflect and refine: using video review as an initiative to improve neonatal care Pediatr. Res. (IF 3.6) Pub Date : 2024-02-14 Veerle Heesters, Henriette A. van Zanten, Veerle Heijstek, Arjan B. te Pas, Ruben S.G.M. Witlox
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Global cross-sectional survey on neonatal pharmacologic sedation and analgesia practices and pain assessment tools: impact of the sociodemographic index (SDI) Pediatr. Res. (IF 3.6) Pub Date : 2024-02-13 Cristina Arribas, Giacomo Cavallaro, Juan-Luis Gonzalez, Carolina Lagares, Genny Raffaeli, Anne Smits, Sinno H. P. Simons, Eduardo Villamor, Karel Allegaert, Felipe Garrido
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Impact of cesarean section on metabolic syndrome components in offspring rats Pediatr. Res. (IF 3.6) Pub Date : 2024-02-12 Mingxuan Zhang, Mengjiao Liu, Long Zhang, Zhangjian Chen, Yu-Bo Zhou, Hong-Tian Li, Jian-Meng Liu
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Genetic susceptibility for retinopathy of prematurity and its associated comorbidities Pediatr. Res. (IF 3.6) Pub Date : 2024-02-12 Lucas G. Gimenez, Juan A. Gili, Darío E. Elias, Rubén Sagula, Belén Comas, María R. Santos, Hebe Campaña, Fernando A. Poletta, Silvina L. Heisecke, Julia Ratowiecki, Viviana R. Cosentino, Rocío Uranga, César Saleme, Mercedes Negri, Mónica Rittler, Jorge Zapata Barrios, Hugo B. Krupitzki, Jorge S. López Camelo
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Community hospital-based clinical research: a vehicle for increasing health equity Pediatr. Res. (IF 3.6) Pub Date : 2024-02-12 Stephanie Smith, Mark Waltzman
Clinical research programs situated within community hospital (CH) settings are uniquely positioned to offer an array of opportunities to patients, researchers and communities alike. CHs are defined broadly by the American Hospital Association as “all non-federal, short-term general, and other special hospitals”; in the United States (US) 5,157 institutions met this definition in 2023.1 CHs work to
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Hypertensive disorders of pregnancy increase the incidence of febrile seizures in offspring. A slightly blurry photo with excellent framing Pediatr. Res. (IF 3.6) Pub Date : 2024-02-12 Francesco Brigo
Assessing causality in medicine is a complex and challenging task. Establishing an association between two phenomena does not automatically imply a direct causal relationship. Before concluding causality, one should first consider and rule out the possibility that the observed association is due to chance, systematic error (i.e., bias), or confounding. ‘Association is not causation’ is the guiding
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Concentrations of remdesivir and GS-441524 in human milk from lactating individuals diagnosed with COVID-19 Pediatr. Res. (IF 3.6) Pub Date : 2024-02-12 Kerri Bertrand, Yadira Sepulveda, Benjamin J. Spiegel, Brookie M. Best, Raymond Suhandynata, Steven Rossi, Christina D. Chambers, Jeremiah D. Momper
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Craniofacial syndromes and class III phenotype: common genotype fingerprints? A scoping review and meta-analysis Pediatr. Res. (IF 3.6) Pub Date : 2024-02-12 Maria Cristina Faria-Teixeira, Cristina Tordera, Francisco Salvado e Silva, António Vaz-Carneiro, Alejandro Iglesias-Linares
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Revolutionizing congenital central hypoventilation syndrome screening: the potential of machine learning approaches Pediatr. Res. (IF 3.6) Pub Date : 2024-02-10 Qinchang Chen, Shushui Wang
Congenital central hypoventilation syndrome (CCHS) is a rare autosomal dominant disorder characterized by central hypoventilation and apnea due to attenuated or absent peripheral and central chemoreceptor responsiveness.1 CCHS can present at any age, as early as within hours of birth, and sometimes may be misdiagnosed as sudden infant death syndrome (SIDS) due to unexplained prolonged apnea leading