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Impact of the 2022 national formula shortage on clinical decision-making of healthcare providers in switching amino acid formulas for infants with cow’s milk protein allergy: a survey-based study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-15 Jessica V. Baran, Jerry M. Brown, Andrew A. Farrar, Lea V. Oliveros, Jesse Beacker, Luke Lamos, Jared Florio, Abigail L. Fabbrini, Michael J. Wilsey
BackgroundIn 2022, the United States experienced a national shortage of infant formula due to a global supply chain crisis and a large-scale domestic formula recall. The existing literature on healthcare providers' (HCPs) clinical decision-making during formula shortages is limited. This study aims to analyze the factors influencing pediatric HCP clinical decision-making when switching between amino
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Association between late bedtime and obesity in children and adolescents: a meta-analysis Front. Pediatrics (IF 2.6) Pub Date : 2024-03-15 Na Hu, Ying Wu, Qing Yao, Shixiang Huang, Wen Li, Zhenhua Yao, Chunfeng Ye
BackgroundShort sleep duration has been related to obesity in children and adolescents. However, it remains unknown whether late bedtime is also associated with obesity and whether the association is independent of sleep duration. A meta-analysis was performed to address this issue.MethodsIn order to accomplish the aim of the meta-analysis, a comprehensive search was conducted on databases including
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Incidence of central precocious puberty declines to pre-pandemic levels post COVID-19 pandemic increase: single-center retrospective review in the United States Front. Pediatrics (IF 2.6) Pub Date : 2024-03-15 Marcela Vargas Trujillo, Tiranun Rungvivatjarus, Karen O. Klein
Background and aim of the studyWe previously published the increased frequency of new CPP cases during the Covid-19 pandemic in our pediatric endocrinology clinic at Rady Children's Hospital in San Diego, CA, US. We conducted this follow-up study to examine the incidence of new CPP cases requiring treatment with GnRH agonist (GnRHa) in our clinic during 2 years post-pandemic.MethodsWe performed a retrospective
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Canakinumab in the treatment of systemic juvenile idiopathic arthritis: a retrospective single center study in China Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Xiaona Zhu, Ruohang Weng, Yanyan Huang, Yongbin Xu, Jun Yang, Tingyan He
ObjectiveSystemic juvenile idiopathic arthritis (sJIA) is characterized by excessive production of proinflammatory cytokines. As an anti-IL-1 agent, canakinumab has been approved in the USA and Europe for the treatment of sJIA patients aged ≥2 years. However, the use of canakinumab has never been reported in China. In this study, we aimed to assess the efficacy and safety of canakinumab in Chinese
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Laparoscopic pyeloplasty for newborns with severe hydronephrosis Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Tong Shi, Weihua Lao, Keyu Ouyang, Yueqing Chen, Yikui Zhang, Jiayao Luo, Shuhan Chen
AimWe aimed to investigate the short-term efficacy and safety of laparoscopic pyeloplasty for treating newborns with severe hydronephrosis due to ureteropelvic junction obstruction (UPJO).MethodsA retrospective analysis was performed on 16 newborn patients with severe neonatal hydronephrosis who underwent laparoscopic pyeloplasty at our hospital from January 2021 to November 2022. All patients were
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Comparative assessment of myocardial function between late premature newborns and term neonates using the 2D speckle tracking method Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Daniela Toma, Amalia Făgărășan, Andreea Cerghit-Paler, Rodica Togănel, Manuela Cucerea, Maria Oana Săsăran, Liliana Gozar
IntroductionAssessment of myocardial function through speckle tracking echocardiography (STE) can bring benefits to conventional echocardiography in premature newborns, a particular vulnerable group in terms of adaptation to extra-uterine life. Furthermore, it represents a non-invasive imagistic method which can guide therapeutic approach in the hemodynamically unstable newborn. This study aims to
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Multisensory stimulation and its effect on breast milk volume production in mothers of premature infants Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Carla Madeleine Cuya, Carlos Barriga, Maria del Carmen Graf, Mirta Cardeña, María del Pilar Borja, Richard Condori, Moises Azocar, Carlos Cuya
IntroductionIn a significant number of NICUs, mothers are unable to provide enough maternal milk to feed their premature babies, so healthcare workers rely on human milk banks. Unfortunately, this service is not available in many countries, such as Peru, where premature infants receive formula. The aim of this study was to determine the effectiveness of multisensory stimulation on mother's own milk
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Centralization as the key survival benefit in acute neonatal surgery Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Manuel Besendörfer, Simone Günster, Katja Linz, Heiko Martin Reutter, Sonja Diez
IntroductionCentralization of neonatal surgical care for congenital malformations is already under discussion. Acute care of neonatal emergencies in perinatal centers with affiliated hospitals is not uniformly regulated in Germany.Materials and methodsAnalyses are based on acute pediatric surgical care at four affiliated hospitals of a perinatal center. Epidemiologic data and outcome parameters “survival”
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Respiratory morbidity in patients with spinal muscular atrophy—a changing world in the light of disease-modifying therapies Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Leen Lagae, Marijke Proesmans, Marleen Van den Hauwe, François Vermeulen, Liesbeth De Waele, Mieke Boon
Respiratory complications are common in spinal muscular atrophy (SMA) and significantly contribute to morbidity and mortality in these patients. Generalized respiratory and bulbar muscle weakness translates into diverse and complex clinical consequences necessitating strict follow-up and specialized care. The natural history of SMA has evolved drastically in recent years as a result of the introduction
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Social determinants of health rather than race impact health-related quality of life in 10-year-old children born extremely preterm Front. Pediatrics (IF 2.6) Pub Date : 2024-03-14 Catherine Call, Ali Oran, T. Michael O’Shea, Elizabeth T. Jensen, Jean A. Frazier, Ruben Vaidya, Jeffrey Shenberger, Semsa Gogcu, Michael E. Msall, Sohye Kim, Isha Jalnapurkar, Rebecca C. Fry, Rachana Singh
BackgroundReducing healthcare disparities among children is extremely important given the potential impact of these disparities on long-term health-related quality of life (HRQL). Race and parental socioeconomic status (SES) are associated with child HRQL, but these associations have not been studied in infants born extremely preterm (EP), a population at increased risk for physical, cognitive, and
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Manual reduction in testicular torsion and subsequent treatment after successful reduction: a series of reports in a single institution Front. Pediatrics (IF 2.6) Pub Date : 2024-03-11 Xiaokang Qi, Junjie Yu, Xuefei Ding, Yehua Wang, Haiyan Zhu
IntroductionTo explore the factors affecting the success of testicular torsion manual reduction and the safety of subsequent conservative treatment after successful reduction.MethodsClinical data of 66 patients with testicular torsion treated in our emergency department from February 2017 to February 2022 were retrospectively collected. Manual reduction without anesthesia was performed in 19 patients
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The efficacy of gradual reduction using two-stage traction for developmental dysplasia of the hip in southern China Front. Pediatrics (IF 2.6) Pub Date : 2024-03-11 Hui Chen, Xiang-xuan Wang, Zhao Chen, Yihua Ge
PurposeThis study aimed to report the preliminary outcome of gradual reduction (GR) utilizing two-stage traction (TST) compared with traditional traction (TT) in the treatment of developmental dysplasia of the hip (DDH) and to evaluate whether the prognosis of the TST is better than that of TT.MethodsThe following information on children diagnosed with DDH who underwent treatment with GR using two-stage
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Clinical analysis of infectious mononucleosis complicated with acute acalculous cholecystitis Front. Pediatrics (IF 2.6) Pub Date : 2024-03-08 Caijie Gao, Liming Cao, Xiaoli Mei
ObjectiveThis study aimed to investigate specific clinical diagnostic methods for children with infectious mononucleosis (IM) complicated by acute acalculous cholecystitis (AAC).MethodsWe conducted a retrospective analysis of 171 cases of IM diagnosed in the infectious disease ward of Children's Hospital of Nanjing Medical University between January 2020 and December 2020. All IM patients underwent
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Experience in the treatment of long-gap esophageal atresia by intraluminal esophageal stretching elongation Front. Pediatrics (IF 2.6) Pub Date : 2024-03-08 Ning Zhang, Wenjie Wu, Yujia Zhuang, Weipeng Wang, Weihua Pan, Jun Wang
ObjectiveTo summarize the experience with intraluminal esophageal stretching elongation (ILESE) in the successful treatment of long-gap esophageal atresia (LGEA) at a single center.MethodsClinical data of 68 neonates who underwent LGEA between February 2015 and January 2022 were retrospectively analyzed. Four patients died of multiple associated severe malformations and did not undergo ILESE. Esophageal
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Myeloid cells as potential targets for immunotherapy in pediatric gliomas Front. Pediatrics (IF 2.6) Pub Date : 2024-03-08 Stephen C. Frederico, Nikhil Sharma, Corbin Darling, Suchet Taori, Alexandra C. Dubinsky, Xiaoran Zhang, Itay Raphael, Gary Kohanbash
Pediatric high-grade glioma (pHGG) including pediatric glioblastoma (pGBM) are highly aggressive pediatric central nervous system (CNS) malignancies. pGBM comprises approximately 3% of all pediatric CNS malignancies and has a 5-year survival rate of approximately 20%. Surgical resection and chemoradiation are often the standard of care for pGBM and pHGG, however, even with these interventions, survival
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Characteristics of adolescents referred for bariatric surgery in Abu Dhabi, United Arab Emirates Front. Pediatrics (IF 2.6) Pub Date : 2024-03-08 Reem Hassan Beck, Imrana Afrooz, Muhammad Suhail Masalawala, Rama Watad, Talat Al Shaban, Asma Deeb
About a third of children and adolescents are overweight or obese in the United Arab Emirates, and referrals for metabolic and bariatric surgery (MBS) are now common. Despite excellent evidence that MBS should be considered in adolescents with severe obesity, it remains a management approach of last resort in many cases. Baseline, real-world data on adolescent patients living with obesity referred
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Predictors of postoperative delirium in paediatric patients undergoing surgery under general anaesthesia at Amhara Regional State Tertiary Hospitals: a multicenter prospective study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-08 Debas Yaregal Melesse, Tadesse Teshale Tesema, Zemenay Ayinie Mekonnen, Wubie Birlie Chekol, Biruk Adie Admass, Misganaw Mengie Workie
IntroductionPostoperative delirium in paediatric patients is a recognised issue. Nevertheless, in low- and middle-income nations, researchers have had luck in determining its extent and predictors. Identifying predictors of postoperative delirium in paediatric patients having general anaesthesia at Tertiary Hospitals in Ethiopia was the aim of this study.MethodsA multicenter, prospective follow up
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Dietary habits, depression and obesity: an intricate relationship to explore in pediatric preventive strategies Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Valeria Calcaterra, Virginia Rossi, Vittoria Carlotta Magenes, Paola Baldassarre, Roberta Grazi, Martina Loiodice, Valentina Fabiano, Gianvincenzo Zuccotti
Obesity and depression represent major health problems due to their high prevalence and morbidity rates. Numerous evidences elucidated the connections between dietary habits and the incidence or severity of depression. This overview aims to investigate the intricate relationship between dietary patterns and depression with the objective of elaborating preventive strategies for childhood obesity. Literature
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Epidemiology and distribution of cruciate ligament injuries in children and adolescents, with an analysis of risk factors for concomitant meniscal tear Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Xinwang Zhi, Zhicheng Wen, Jiexin Zhang, Dongbo Lai, Huilan Ye, Jianping Wu, Jintao Li, Yan Shao, Federico Canavese, Chun Zeng, Hongwen Xu
IntroductionTo investigate the epidemiological features and prevalence of cruciate ligament injuries (CLI) in children and adolescents, and to examine the potential risk factors associated with concomitant meniscal tear (MT) among this population.MethodsThe demographic data and injury details of children and adolescents with CLI from Southeast China were analyzed to describe their distribution characteristics
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Early outcomes of moderate-to-high-risk pediatric congenital cardiac surgery and predictors of extracorporeal circulatory life support requirement Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Mimi Xiaoming Deng, Christoph Haller, Kasey Moss, Sudipta Saha, Kyle Runeckles, Chun-Po Steve Fan, Bhavikkumar Langanecha, Alejandro Floh, Anne-Marie Guerguerian, Osami Honjo
BackgroundCardiopulmonary failure refractory to medical management after moderate-to-high-risk congenital cardiac surgery may necessitate mechanical support with veno-arterial extracorporeal membrane oxygenation (ECMO). On the extreme, ECMO can also be initiated in the setting of cardiac arrest (extracorporeal cardiopulmonary resuscitation, ECPR) unresponsive to conventional resuscitative measures
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Probiotics' effects on gut microbiota in jaundiced neonates: a randomized controlled trial protocol Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Chen Jiayi, Wei Jinying, Yuan Yanhan, Liu Tianyu, Chen Juanjuan, Zhang Feng, Fang Xiaohui, Zhang Jinping
IntroductionRecent evidence suggests that blue-light phototherapy impacts gut microbiota composition in jaundiced newborns, leading to disturbances closely related to the therapy's side effects. As a result, gut microbiota may serve as a potential intervention target to mitigate these side effects. In this study, we aim to examine the effects of AB-GG (Lactobacillus rhamnosus LGG), Bb-12 (Bifidobacterium
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Prone position in the mechanical ventilation of acute respiratory distress syndrome children: a systematic review and meta-analysis Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Wen Qin, Lei Mao, Yue Shen, Li Zhao
BackgroundProne position has been well recognized for the treatment of adult acute respiratory distress syndrome (ARDS). We aimed to evaluate the role of prone position in the mechanical ventilation in children with ARDS, to provide evidence to the treatment and care of children with ARDS.MethodsWe searched the Pubmed et al. databases by computer until January 23, 2024 for randomized controlled trials
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Elasticity and cross-sectional thickness of paraspinal muscles in progressive adolescent idiopathic scoliosis Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Yunli Fan, Haiping Zheng, Lin Feng, Michael K. T. To, Guan-Ming Kuang, Eric H. K. Yeung, Kenneth M. C. Cheung, Li Liu, Jason P. Y. Cheung
Objectives(1) Compare the cross-sectional thickness (CST) and shear wave speed (SWS) of paraspinal muscles (PSM) in adolescent idiopathic scoliosis (AIS) with and without curve progression; (2) investigate the relationship between CST/SWS and radiographic characteristics in AIS with curve progression; (3) compare the CST/SWS between AIS and non-scoliosis controls.MethodsThis cross-sectional study analyzed
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Reintegration into school, kindergarten and work in families of childhood cancer survivors after a family-oriented rehabilitation program Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Laura Inhestern, Mona L. Nasse, Konstantin A. Krauth, Daniela Kandels, Stefan Rutkowski, Gabriele Escherich, Corinna Bergelt
ObjectiveTo describe the situation of childhood cancer survivors and their parents before and one year after a family-oriented rehabilitation program (FOR) and to identify factors influencing reintegration.MethodsWe included parents of children diagnosed with leukemia or central nervous system tumor. We assessed parental functioning using the functioning subscale of the Ulm Quality of Life Inventory
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Incidence and predictors of virological failure among children receiving first-line anti-retroviral treatment in public comprehensive specialized hospitals found in Northeast Ethiopia: a retrospective follow-up study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Estifanos Belay Abebe, Meseret Ekubay Gebregeorgis, Fuad Ahmed Seid, Alemu Birara Zemariam, Tadesse Mamo Dejene, Seteamlak Adane Masresha
BackgroundDespite anti-retroviral treatment coverage in resource-limited countries being highly appreciated, the occurrence of first-line virological failure remains a priority agenda. Therefore, this study serves as an input for evidence of virological failure among children.ObjectiveThis study aimed to assess the incidence and predictors of virological failure among children receiving first-line
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Case Report: Profound newborn leukopenia related to a novel RAC2 variant Front. Pediatrics (IF 2.6) Pub Date : 2024-03-07 Geoffrey Hall, Ágnes Donkó, Cristina Pratt, Julie J. Kim-Chang, Paul L. Martin, Amy P. Stallings, John W. Sleasman, Steven M. Holland, Amy P. Hsu, Thomas L. Leto, Talal Mousallem
We report the case of a 1-week-old male born full-term, who had two inconclusive severe combined immunodeficiency (SCID) newborn screens and developed scalp cellulitis and Escherichia coli bacteremia. He did not pass early confirmatory hearing screens. Initial blood counts and lymphocyte flow cytometry revealed profound neutropenia and lymphopenia with a T-/B-/NK- phenotype. Red blood cell adenosine
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Case Report: TRPV4 gene mutation causing neuronopathy, distal hereditary motor, type VIII Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Fengge Wang, Xuemei Jin, Yongning Zhu, Shuli Jiang, Xiaoyan Zhang, Yanping Wang, Dongmei Man, Fuling Wang
Neuronopathy, distal hereditary motor, type VIII is an exceedingly rare autosomal dominant genetic disorder, also known as congenital non-progressive distal spinal muscular atrophy. It is characterized by progressive weakness in distal motor function and atrophy of muscles, without accompanying sensory impairment. Presently, there is limited literature on this condition, and accurate epidemiological
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Examining the relationship between meeting 24-hour movement behaviour guidelines and mental health in Chinese preschool children Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Long Yin, Fang Li, Pan Liu, Zhiqiang Yin, Zongyu Yang, Linchun Pi, Zan Gao
Background Limited research has explored the relationship between adhering to 24-h Movement Behaviour guidelines and mental health in Chinese preschool children. The objectives of this study encompassed two primary goals: (1) to investigate the adherence of preschool children in China to the 24-h Movement Behaviour guidelines; and (2) to analyze the relationship between fulfilling various combinations
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Clinical characteristic, common sites, and geographical distribution of pediatric tuberculosis patients in Southwest China Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Dong-Mei Wang, Chuan Wang, Qi An, Qing Yang, Yi Liao
Background The data report of a large sample, dynamic epidemiology, and characteristic analysis of pediatric tuberculosis (TB) in Southwest China is not clear. Herein, we conducted descriptive dynamic epidemiology, characteristic analysis and geographical distribution study of pediatric TB inpatients in Southwest China for more than 20 years. Methods Patients with pediatric TB were recruited from October
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Global trends in the research on Legg–Calve–Perthes disease in Web of Science Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Wenbao Qin, Mingwei He, Hongsheng Qin, Qingjun Wei, Haiwei Yan
BackgroundLegg–Calve–Perthes disease (LCPD) is a form of idiopathic femoral head necrosis that can lead to permanent femoral head deformities and premature osteoarthritis in children under the age of 15. Its pathogenesis is utterly and remains to be clarified. Although many research publications on LCPD have emerged during the last few decades, few systematic bibliometric analyses of these articles
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Hyperglycemia in pregnancy did not worsen the short-term outcomes of very preterm infants: a propensity score matching study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Ying Li, Wei Shen, Rong Zhang, Jian Mao, Ling Liu, Yan-Mei Chang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Xiao-Mei Tong, Xin-Zhu Lin, Fan Wu
BackgroundHyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes in offspring, but its impact on the short-term outcomes of very preterm infants remains unclear.MethodsA secondary analysis was performed based on clinical data collected prospectively from 28 hospitals in seven regions of China from September 2019 to December 2020. According to maternal
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The epidemiological characteristics of liver disease in hospitalized children: a 10-year single-center retrospective study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Fan Chen, Yuan Huang, Zhihua Huang, Feng Fang, Hua Zhou, Sainan Shu
BackgroundThis investigation aimed to examine the epidemiological characteristics of children with liver disease hospitalized for the first time between June 2012 and May 2022 in a tertiary hospital.MethodsThe study retrospectively recruited children aged between 29 days and 18 years who had been hospitalized for liver disease. Clinical characteristics were categorized by age and etiology, and time
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Pubertal gynecomastia incidence among 530,000 boys: a cross sectional population based study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Ori Berger, Tzipi Hornik-Lurie, Ran Talisman
BackgroundAdolescent gynecomastia, a benign proliferation of male breast tissue, can lead to psychological issues during adolescence. The prevalence varies widely (4%−69%). The incidence peaks are during neonatal, pubertal, and senescent periods. Its affect on emotional well-being necessitates understanding and occasional intervention. This study aimed to determine the incidence of gynecomastia among
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Association between red cell distribution width-to-albumin ratio and prognostic outcomes in pediatric intensive care unit patients: a retrospective cohort study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Rui Jing, Baolong Yu, Chenchen Xu, Ying Zhao, Hongmei Cao, Wenhui He, Haili Wang
ObjectiveThis study aimed to assess the association between Red Cell Distribution Width-to-Albumin Ratio (RAR) and the clinical outcomes in Pediatric Intensive Care Unit (PICU) patients.DesignThis is a retrospective cohort study.MethodsWe conducted a retrospective cohort study based on the Pediatric Intensive Care database. The primary outcome was the 28-day mortality rate. Secondary outcomes included
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Cardiac injury progression in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection: a review Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Song Su, Wandong Hu, Xiao Chen, Ying Ren, Yi Lu, Jianguo Shi, Tong Zhang, Huan Zhang, Meng Wang, Yaping Wang, Fen Zhao, Ruifeng Jin, Yong Liu, Hongwei Zhang, Guohua Liu
The symptoms and signs of infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are milder in children than in adults. However, in April 2020, British pediatricians first reported that coronavirus disease 2019 (COVID-19) may present as multisystem inflammatory syndrome in children and adolescents (MIS-C), similar to that observed in Kawasaki disease. MIS-C can be associated
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Criteria of ultrasound-guided closed reduction with percutaneous pinning in unstable humeral lateral condylar fractures: a three-center retrospective cohort study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Xiuming Huang, Chaoyu Liu, Guoqiang Jia, Jie Yao, Jianbing Xu
BackgroundInterventions using ultrasound-guided closed reduction and percutaneous pinning (UG-CRPP) of humeral lateral condylar fractures (HLCFs) have been increasingly applied; however, their effectiveness for unstable HLCFs and the criteria for ultrasound outcomes remain unclear. This study assessed the outcomes of UG-CRPP for HLCFs and evaluated the success criteria in children.MethodsData were
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Timeline of diagnosed pain causes in children with severe neurological impairment Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Francesca Peri, Elena Magni, Filippo Pigani, Raffaella Romoli, Simona Vetrella, Lucia De Zen, Raffaella Sagredini, Egidio Barbi, Giorgio Cozzi
ObjectivePain's causes in children with severe cognitive impairment may be challenging to diagnose. This study aimed to investigate if there is a relationship between pain causes and the age of children.MethodsWe conducted a multicenter retrospective study in three Italian Pediatric Units. Eligible subjects were patients from 1 to 18 years with severe neurological impairment. We collected data regarding
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Speech, language, functional communication, psychosocial outcomes and QOL in school-age children with congenital unilateral hearing loss Front. Pediatrics (IF 2.6) Pub Date : 2024-03-06 Linda Cupples, Teresa Y. C. Ching, Sanna Hou
IntroductionChildren with early-identified unilateral hearing loss (UHL) might be at risk for delays in early speech and language, functional communication, psychosocial skills, and quality of life (QOL). However, a paucity of relevant research prohibits strong conclusions. This study aimed to provide new evidence relevant to this issue.MethodsParticipants were 34 children, ages 9;0 to 12;7 (years;months)
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Development of a clinical prediction tool for extubation failure in pediatric cardiac intensive care unit Front. Pediatrics (IF 2.6) Pub Date : 2024-03-05 Kwannapas Saengsin, Rekwan Sittiwangkul, Thirasak Borisuthipandit, Pakpoom Wongyikul, Krittai Tanasombatkul, Thanaporn Phanacharoensawad, Guanoon Moonsawat, Konlawij Trongtrakul, Phichayut Phinyo
Introduction/objectiveExtubation failure in pediatric patients with congenital or acquired heart diseases increases morbidity and mortality. This study aimed to develop a clinical risk score for predicting extubation failure to guide proper clinical decision-making and management.MethodsWe conducted a retrospective study. This clinical prediction score was developed using data from the Pediatric Cardiac
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Case Report: Identification of a CARD8 variant in all three patients with PFAPA syndrome complicated with Kawasaki disease Front. Pediatrics (IF 2.6) Pub Date : 2024-03-05 Haruhiko Nakamura, Atsuo Kikuchi, Hideyuki Sakai, Miki Kamimura, Yohei Watanabe, Ryoichi Onuma, Jun Takayama, Gen Tamiya, Yoichi Mashimo, Ryota Ebata, Hiromichi Hamada, Tomohiro Suenaga, Yoshihiro Onouchi, Satoru Kumaki
BackgroundPeriodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome), and Kawasaki disease (KD) are both considered to be disorders of the innate immune system, and the potential role of inflammasome activation in the immunopathogenesis of both diseases has been previously described.Case presentationHerein, we report the clinical courses of three patients who presented
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The frequency and timing of sepsis-associated coagulopathy in the neonatal intensive care unit Front. Pediatrics (IF 2.6) Pub Date : 2024-03-05 Khyzer B. Aziz, Matthew Saxonhouse, Divya Mahesh, Kathryn E. Wheeler, James L. Wynn
IntroductionSepsis is a common cause of morbidity and mortality in the neonatal intensive care unit (NICU). The frequency and severity of sepsis-associated coagulopathy as well as its relationship to illness severity are unclear.MethodsWe performed a single-center, retrospective, observational cohort study of all infants admitted to the University of Florida Health (UF Health), level IV NICU between
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Effect of inspiratory muscle training in children with asthma: a systematic review and meta-analysis of randomized controlled trials Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Yuping Xiang, Tianhui Luo, Xinyang Chen, Huanhuan Zhang, Ling Zeng
Background Asthma is a common chronic respiratory disease in children. Alongside pharmacological interventions, inspiratory muscle training (IMT) emerges as a complementary therapeutic approach for asthma management. However, the extent of its efficacy in pediatric populations remains uncertain when compared to its benefits in adults. This systematic review aims to evaluate the effectiveness of IMT
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Application of enhanced recovery after surgery during the perioperative period in children with Meckel’s diverticulum–a single-center prospective clinical trial Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Cuicui Wang, Youliang Wang, Ping Zhao, Ting Li, Fan Li, Zhi Li, Yingwen Qi, Xuewu Wang, Weidong Shi, Lina Liu, Gamei Li, Yong Wang
Background Enhanced recovery after surgery (ERAS) has been widely used in adult surgery. However, few studies have reported the efficacy of ERAS in paediatric patients with Meckel's diverticulum (MD), the aim of the study was to prospectively evaluate the safety and efficacy of ERAS in treating MD. Methods A prospective randomised controlled study of children with MD admitted to our hospital from Jan
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Combined surgery and sclerotherapy for 13 years: a case report of a patient with CLOVES Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Shiqi Wang, Siming Yuan
Congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and skeletal anomalies (CLOVES) constitute a rare overgrowth disorder resulting from a mosaic function-acquiring mutation in the PIK3CA gene. Targeted drugs for the PI3K-AKT signaling pathway remain under clinical trial and surgery is commonly used to meet both aesthetic and functional requirements for CLOVES patients. We report
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Caucasian and African American racial disparity in neonatal hospital mortality Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Maria Burdjalov, Ibrahim Qattea, Vanishree Nandakumar, Mohamed A. Mohamed, Hany Aly
ObjectiveTo examine disparity in hospital mortality among Caucasian (C) and African American (AA) neonates born at different gestational ages (GA).MethodsDe-identified national inpatient data were obtained from the Healthcare Cost and Utilization Project (HCUP) from the Agency for Healthcare Research and Quality (AHRQ) for the years 2011–2018. We compared the odds ratio for mortality among C and AA
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Morquio B disease: a case report Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Tara Gholamian, Harpreet Chhina, Sylvia Stockler, Anthony Cooper
Mucopolysaccharidosis IV type B, or Morquio B disease (MBD), is an autosomal recessive disorder caused by a genetic mutation in GLB1 gene encoding for β-galactosidase on chromosome 3p22.33. β-galactosidase deficiency can result in two different conditions, GM1 gangliosidosis and MBD, of which MBD has a milder phenotype and presents later in life with keratan sulfate accumulation in the retina and cartilage
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Clinical and laboratory parameters associated with febrile seizure recurrence within the first 24 h: a ten-year cohort study Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Massimo Luca Castellazzi, Adriano La Vecchia, Martina Scali, Carlo Agostoni, Giada Di Pietro, Gregorio Paolo Milani
IntroductionWe assessed clinical and laboratory parameters associated with early recurrence of febrile seizure in patients presenting at the Emergency Department with a first episode.MethodsCase series of patients admitted to the emergency department with the first episode of febrile seizure for ten consecutive years. Exclusion criteria were focal features and prolonged duration (>15 min).ResultsWe
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Case Report: ECMO-assisted tracheal reconstruction in a 30-week-gestation preterm infant with tracheal stenosis Front. Pediatrics (IF 2.6) Pub Date : 2024-03-04 Zi-Hao Li, Shi-Hao Li, Zhen-Yang Geng, Bin Wu, Yin-Liang Sheng, Ping Yuan, Feng Li, Yu Qi
Tracheal stenosis is a rare but life-threatening disease in preterm infants. Misdiagnosis as congenital tracheal stenosis is common, making surgical management challenging. This report presents a case of a preterm infant with tracheal stenosis and congenital heart malformation treated with ECMO-assisted tracheal resection and end-to-end anastomosis. A male infant was born at 30 weeks of gestation with
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The change of psychosocial stress factors in families with infants and toddlers during the COVID-19 pandemic. A longitudinal perspective on the CoronabaBY study from Germany Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Catherine Buechel, Anna Friedmann, Stefan Eber, Uta Behrends, Volker Mall, Ina Nehring
Background Over nearly three years, the COVID-19 pandemic has had a lasting impact on people's lives and mental health worldwide with its far-reaching restrictions and concerns about infections and other personal consequences. Families were particularly affected and showed increased stress and psychological problems. Long-term effects cannot be ruled out. So far, data on young families are sparse.
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Managing infectious diarrhea among young children in community pharmacies in Saudi Arabia and the implications for AMR Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Faris S. Alnezary, Amira R. Alamri, Rafa D. Alrehaili, Dina S. Alnizari, Fahad Alzahrani, Mansour Mahmoud, Masaad S. Almutairi, Amanj Kurdi, Brian Godman
Introduction Diarrhea remains a major global health issue for children under five, contributing substantially to morbidity and mortality. Community pharmacists play a pivotal role in the management of these children; however, their competence in managing childhood diarrhea in Saudi Arabia is under-researched. This is important to ensure optimal patient care. Method Simulated patients (SPs) presenting
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Referent data for investigations of upper limb accelerometry: harmonized data from three cohorts of typically-developing children Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Catherine E. Lang, Catherine R. Hoyt, Jeffrey D. Konrad, Kayla R. Bell, Natasha Marrus, Marghuretta D. Bland, Keith R. Lohse, Allison E. Miller
AimThe rise of wearable sensing technology shows promise for addressing the challenges of measuring motor behavior in pediatric populations. The current pediatric wearable sensing literature is highly variable with respect to the number of sensors used, sensor placement, wearing time, and how data extracted from the sensors are analyzed. Many studies derive conceptually similar variables via different
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Burkitt's lymphoma in a young boy progressing to systemic lupus erythematosus during follow-up: a case report and literature review Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Chenxi Liu, Ci Pan, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Shengfang Bao, Xiqiong Han, Yanliang Jin
IntroductionPatients with systemic lupus erythematosus (SLE) are at a higher risk of developing cancer, particularly hematological malignancies such as lymphoma and leukemia. However, existing studies on this topic that assess cancer incidence following SLE diagnosis are limited. In addition, SLE can be diagnosed after cancer, although such cases in children have been rarely reported.Case reportWe
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Survey of knowledge, practice, and associated factors toward home management of childhood fever among parents visiting Gondar health facilities in 2022 Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Nega Tezera Assimamaw, Almaz Tefera Gonete, Bewuketu Terefe
BackgroundFever is a typical symptom of many sicknesses, but for children under the age of five, fever can have devastating consequences and represents a source of worry for parents. To the best of our knowledge, no research on home management of fever in children has been conducted in Ethiopia. We aimed to assess knowledge, practices, and associated factors towards home management of childhood fever
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Case Report: Ventricular preexcitation-induced dilated cardiomyopathy improved by the pharmacologic suppression of ventricular preexcitation in three infants, and literature review Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Dai Chencheng, Zhong Min, Shi Wanming, Shangguan Wen, Guo Baojing, Xiao Yanyan, Han Ling, Long Deyong
The therapy of ventricular preexcitation-induced dilated cardiomyopathy in very small infants or infants with a high risk of ablation is tough and related articles are rare. Effective pharmacotherapy to suppress ventricular preexcitation is valuable.AimsTo evaluate the effectiveness and safety of pharmacotherapy for cardiac resynchronization in infants with ventricular preexcitation-induced dilated
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Long-term outcomes of liver transplantation for biliary atresia and results of policy changes: over 20 years of follow-up experience Front. Pediatrics (IF 2.6) Pub Date : 2024-03-01 Yiyoung Kwon, Yoon Ji Ahn, Jaehun Yang, Eun Sil Kim, Yon Ho Choe, Sanghoon Lee, Mi Jin Kim
ObjectiveBiliary atresia (BA) patients develop chronic liver disease after the Kasai operation and are eventually indicated for liver transplantation (LT). The purposes of this study were to analyze long-term outcomes after LT and risk factors that affect complications to reduce graft failure.Study designOverall, 145 pediatric patients who underwent LT between June 1996 and June 2020 after a diagnosis
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Comparing fine motor performance among young children with autism spectrum disorder, intellectual disability, attention-deficit/hyperactivity disorder, and specific developmental disorder of motor function Front. Pediatrics (IF 2.6) Pub Date : 2024-02-29 Ling-Yi Lin, I-Ting Hwang, Chia-Fen Hsu, Wen-Hao Yu, Pei-Chun Lai, Yi-Wen Chen, Yi-Fang Tu
Objective The acquisition of fine motor skills is considered to be a crucial developmental milestone throughout early childhood. This study aimed to investigate the fine motor performance of young children with different disability diagnoses. Methods We enrolled a sample of 1,897 young children under the age of 6 years who were at risk of developmental delays and were identified by a transdisciplinary
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Effect of chronic prenatal exposure to the food additive titanium dioxide E171 on respiratory activity in newborn mice Front. Pediatrics (IF 2.6) Pub Date : 2024-02-29 Eloïse Colnot, Julie O’Reilly, Didier Morin
Nanoparticles (NPs) possess unique properties that make their use valuable in all industries. Titanium dioxide (TiO2) NPs are extensively used as a white pigment in food (labeled under the European number E171) and personal care products, which creates a significant potential for chronic consumer exposure. Concerns about the potential toxic effects of TiO2 NPs have arisen, particularly in vulnerable
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Developing and evaluating a predictive model for neonatal hyperbilirubinemia based on UGT1A1 gene polymorphism and clinical risk factors Front. Pediatrics (IF 2.6) Pub Date : 2024-02-29 Zhaoyang Cui, Wensheng Shen, Xuetong Sun, Yan Li, Ying Liu, Zhiyong Sun
BackgroundNeonatal hyperbilirubinemia (NHB) is one of the most common diseases in the neonatal period. Without timely diagnosis and treatment, it can lead to long-term complications. In severe cases, it may even result in fatality. The UGT1A1 gene and clinical risk factors play important roles in the development and progression of NHB.MethodsIn this study, we conducted a cohort study and analyzed 3258
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In vivo measurement of pediatric extracorporeal oxygenator insensible losses; a single center pilot study Front. Pediatrics (IF 2.6) Pub Date : 2024-02-29 Tess L. Suttles, John Poe, Tara M. Neumayr, Ahmed S. Said
IntroductionFluid overload on Extracorporeal Membrane Oxygenation (ECMO) is associated with worse outcomes. Previous in vitro studies have attempted to quantify oxygenator-related insensible losses, as failure to account for this fluid loss may lead to inaccurate fluid balance assessment and potentially harmful clinical management, such as unnecessary exposure to diuretics, slow continuous ultrafiltration
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A catheterizable serous-lined urinary outlet associated with the ileal bladder augmentation Abol-Enein and Ghoneim procedure: a safe and reliable procedure in children Front. Pediatrics (IF 2.6) Pub Date : 2024-02-29 Hortense Alliot, Toussaint Tapsoba, Annabel Paye-Jaouen, Yaqoub Ashkanani, Eliane Josset-Raffet, Lise Natio, Matthieu Peycelon, Alaa El-Ghoneimi
PurposeThis study aims to evaluate the long-term outcome of the serous-lined extramural continent catheterizable outlet procedure (SLECCOP) associated with ileal bladder augmentation in children.MethodsThis was a monocentric and retrospective study (2002–2021) that included children (<18 years) undergoing the SLECCOP associated with W-shaped ileocystoplasty with a catheterizable channel (Abol-Enein