-
Plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-14 Yaqi Li, Baoling Bai, Hui Wang, Haojie Wu, Yanjun Deng, Chen Shen, Qin Zhang, Lin Shi
Orthostatic intolerance, which includes vasovagal syncope and postural orthostatic tachycardia syndrome, is common in children and adolescents. Elevated plasma homocysteine levels might participate in the pathogenesis of orthostatic intolerance. This study was designed to analyze the plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine. Plasma samples
-
Italian guidelines for the management of irritable bowel syndrome in children and adolescents Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-14 Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo, Claudio Romano, Silvia Salvatore, Michele Saviano, Vincenzo Stanghellini, Caterina Strisciuglio, Renato Tambucci, Rossella Turco, Letizia Zenzeri, Annamaria Staiano
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature
-
Etiological analysis of 167 cases of drug-resistant epilepsy in children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Ran-Ran Zuo, Mei Jin, Su-Zhen Sun
To analyze the etiological distribution characteristics of drug-resistant epilepsy (DRE) in children, with the aim of providing valuable perspectives to enhance clinical practice. In this retrospective study, clinical data were collected on 167 children with DRE who were hospitalized between January 2020 and December 2022, including gender, age of onset, seizure types, video electroencephalogram(VEEG)
-
The effect of parity on time to initiate complementary feeding among mother-infant pairs in Awi Zone, Northwest Ethiopia Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Tilahun Degu Tsega, Gashaw Melkie Bayeh, Kassaye Demeke Alemu, Abaynew Assemu Asrade, Abebaw Molla Kebede, Tamiru Alene, Zewdu Bishaw Aynalem, Bezawit Adane, Melaku Yalew, Molla Getie Mehari, Almaw Genet Yeshiwas, Tadesse Miretie Dessie, Eniyew Talie Fenta, Kefale Mitiku Haylu
Despite strategies and recommendations for complementary feeding initiation were applied globally, mothers initiated complementary feeding to the infants on time was low. Previous works of literatures were not identified the effect of parity on time to initiate complementary feeding. Particularly, evidences regarding to this in Ethiopia is scanty. Therefore, this study aimed to identify the effect
-
Nursing management of patients dealing with spina bifida: from the prenatal diagnosis to adulthood / nursing intervention for the improvement of the impact of urinary and fecal incontinence on the quality of life of people dealing with spina bifida Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Fabiana Calabrese, Antonio Poziello, Gennaro Spiezia, Tiziana Rotunno, Ciro Chervino, Anna Maria Iannicelli
Urinary and fecal incontinence in people dealing with spina bifida, has inevitably an influence on the quality of life. In this analysis, the degree of education on how to manage incontinence and retention is studied, as well as the problems those might create and the consequential degree of autonomy and independence reached into the management of those. The main goal is to increase both nursing assistance
-
Exercise-induced bronchoconstriction, allergy and sports in children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Angela Klain, Mattia Giovannini, Luca Pecoraro, Simona Barni, Francesca Mori, Lucia Liotti, Carla Mastrorilli, Francesca Saretta, Riccardo Castagnoli, Stefania Arasi, Lucia Caminiti, Mariannita Gelsomino, Cristiana Indolfi, Michele Miraglia del Giudice, Elio Novembre
Exercise-induced bronchoconstriction (EIB) is characterized by the narrowing of airways during or after physical activity, leading to symptoms such as wheezing, coughing, and shortness of breath. Distinguishing between EIB and exercise-induced asthma (EIA) is essential, given their divergent therapeutic and prognostic considerations. EIB has been increasingly recognized as a significant concern in
-
Critical illness-related corticosteroid insufficiency (CIRCI) in paediatric patients: a diagnostic and therapeutic challenge Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-11 Letteria Anna Morabito, Domenico Corica, Giorgia Pepe, Alessandra Li Pomi, Tommaso Aversa, Malgorzata Gabriela Wasniewska
Critical illness-related corticosteroid insufficiency or CIRCI is characterized by acute and life-threatening disfunction of hypothalamic–pituitary–adrenal (HPA) axis observed among intensive care unit- staying patients. It is associated with increased circulating levels of biological markers of inflammation and coagulation, morbidity, length of ICU stay, and mortality. Several mechanisms are involved
-
Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-07 Francesca Fortunato, Angelo Campanozzi, Gianfranco Maffei, Fabio Arena, Valeria Delli Carri, Tiziana Rollo, Pier Luigi Lopalco, Domenico Martinelli
Respiratory syncytial virus (RSV), a single-stranded RNA virus, is a leading cause of hospitalization in infants, especially ≤ 2 months of life. In the light new immunization strategies adoption, we described epidemiological and clinical characteristics of RSV-associated hospitalizations in pediatric and neonatal intensive care units of the Policlinico Foggia Hospital, Apulia Region, Italy. Hospitalized
-
Healthcare migration in Italian paediatric haematology-oncology centres belonging to AIEOP Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-07 Roberto Rondelli, Tamara Belotti, Riccardo Masetti, Franco Locatelli, Maura Massimino, Alessandra Biffi, Carlo Dufour, Franca Fagioli, Giuseppe Menna, Andrea Biondi, Claudio Favre, Marco Zecca, Nicola Santoro, Giovanna Russo, Silverio Perrotta, Andrea Pession, Arcangelo Prete
In Italy, there is a network of centres headed by the Italian Association of Pediatric Hematology and Oncology (AIEOP) for the diagnosis and treatment of paediatric cancers on almost the entire national territory. Nevertheless, migration of patients in a hospital located in a region different from that of residence is a widespread habit, sometimes motivated by several reasons. The aim of this paper
-
Distribution of blood lead and cadmium levels in healthy children aged 0 to 18 years and analysis of related influencing factors in Henan, China: data findings from 2017 to 2022 Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-07 Hui Yan, Bo Zhai, Ruiling Feng, Penggao Wang, Fang Yang, Yang Zhou
There is still a lack of data on blood lead levels (BLLs) and blood lead levels (BLLs) in healthy children of all ages from 0 to 18 years in China. This study was performed to analyze the BLLs and BCLs in healthy children aged 0-18 years from 2017 to 2022 in urban and rural areas of Henan Province, Central China, as well as their relationships with socio-demographic variables and certain relevant exposure
-
Pediatric asthma and altitude: a complex interplay between different environmental factors Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-06 Laura Bisoffi, Giovanni Sassudelli, Fabio Agostinis, Annalisa Cogo, Renato Cutrera, Irene Dalpiaz, Maria Elisa Di Cicco, Battista Guidi, Stefania La Grutta, Andrea Miceli, Francesca Mori, Giorgio Piacentini, Diego Peroni, Deborah Snjiders, Mattia Giovannini, Ermanno Baldo
Asthma is one of the most common non-communicable diseases, and its prevalence and morbidity are influenced by a wide array of factors that are only partially understood. In addition to individual predisposition linked to genetic background and early life infections, environmental factors are crucial in determining the impact of asthma both on an individual patient and on a population level. Several
-
Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Chiara Maddaloni, Sara Ronci, Domenico Umberto De Rose, Iliana Bersani, Francesca Campi, Matteo Di Nardo, Francesca Stoppa, Rachele Adorisio, Antonio Amodeo, Alessandra Toscano, Maria Cristina Digilio, Antonio Novelli, Giovanni Chello, Annabella Braguglia, Andrea Dotta, Flaminia Calzolari
TBX4 gene, located on human chromosome 17q23.2, encodes for T-Box Transcription Factor 4, a transcription factor that belongs to the T-box gene family and it is involved in the regulation of some embryonic developmental processes, with a significant impact on respiratory and skeletal illnesses. Herein, we present the case of a female neonate with persistent pulmonary hypertension (PH) who underwent
-
Fatal food anaphylaxis in adults and children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Elio Novembre, Mariannita Gelsomino, Lucia Liotti, Simona Barni, Francesca Mori, Mattia Giovannini, Carla Mastrorilli, Luca Pecoraro, Francesca Saretta, Riccardo Castagnoli, Stefania Arasi, Lucia Caminiti, Angela Klain, Michele Miraglia del Giudice
Anaphylaxis is a life-threatening reaction characterized by the acute onset of symptoms involving different organ systems and requiring immediate medical intervention. The incidence of fatal food anaphylaxis is 0.03 to 0.3 million/people/year. Most fatal food-induced anaphylaxis occurs in the second and third decades of life. The identified risk factors include the delayed use of epinephrine, the presence
-
Associations of maternal serum concentration of iron-related indicators with birth outcomes in Chinese: a pilot prospective cohort study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Geng-dong Chen, Peng-sheng Li, Zi-xing Zhou, Hai-yan Wang, Xiao-yan Gou, Shao-xin Ye, Dong-xin Lin, Da-zhi Fan, Li-juan Wang, Zheng-ping Liu
Previous studies of maternal iron and birth outcomes have been limited to single indicators that do not reflect the comprehensive relationship with birth outcomes. We aimed to investigate the relationship between maternal iron metabolism and neonatal anthropometric indicators using comprehensive iron-related indicators. A total of 914 Chinese mother-child dyads were enrolled in this prospective study
-
Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Ying Chen, Yan Zhang, Qiong-Ni Tang, Hong-Bo Shi
The prevalence of macrolide-resistant Mycoplasma pneumoniae has increased considerably. Treatment in children has become challenging. This study aimed to evaluate the efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods. We retrospectively analyzed the data of patients with macrolide-resistant Mycoplasma pneumoniae pneumonia hospitalized
-
Efficacy of home phototherapy versus inpatient phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-04 Rui Li, Tingting Li, Xudong Yan, Jing Feng, Zhangbin Yu, Cheng Chen
Home phototherapy (HPT) remains a contentious alternative to inpatient phototherapy (IPT) for neonatal hyperbilirubinemia. To guide evidence-based clinical decision-making, we conducted a meta-analysis of randomized clinical trials (RCTs) and cohort studies and assessed the comparative risks and benefits of HPT and IPT. PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure
-
Imported allergens in Italy: an emerging issue Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-03 Luca Pecoraro, Mattia Giovannini, Francesca Mori, Simona Barni, Riccardo Castagnoli, Stefania Arasi, Carla Mastrorilli, Francesca Saretta, Lucia Liotti, Lucia Caminiti, Angela Klain, Mariannita Gelsomino, Michele Miraglia Del Giudice, Elio Novembre
Imported allergens are involved in many allergic reactions, with unexpected and unusual implications. They can be involved in developing asthma, allergic rhinoconjunctivitis, Hymenoptera venom allergies and food allergies. Imported allergens can be implied in respiratory allergies attributable to commercial practices and accidental diffusion through air currents that have introduced non-native species
-
Knowledge, attitudes and behaviours of a sample of Italian paediatricians towards RSV and its preventive strategies: a cross-sectional study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-29 Giulia Congedo, Gaia Surya Lombardi, Doris Zjalic, Mattia Di Russo, Emanuele La Gatta, Luca Regazzi, Giuseppe Indolfi, Annamaria Staiano, Chiara Cadeddu
Respiratory Syncytial Virus (RSV) infection mainly affects newborns, infants and young children aged < 2 years. Since an RSV vaccine is in the European Medicines Agency’s waitlist validation, nowadays the prevention only includes passive immunization with monoclonal antibodies (mAb). In the present study we aimed at investigating Italian paediatricians’ knowledge, attitudes and behaviours towards RSV
-
The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-27 Ezgi Yangin Ergon, Senem Alkan Ozdemir, Sinem Akbay Ak, Meltem Yenilmez, Buse Soysal, Oğuz Han Kalkanlı, Şebnem Çalkavur, Tülin Gokmen Yıldırım
The effect of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus in the neonatal period on developing brain is still unknown. This study aims to investigate the long-term neurodevelopmental outcomes of newborns exposed to SARS-CoV-2 & Delta variant. At a tertiary referral center, a prospective observational cohort research was carried out. All babies who were equal to or more than 34
-
Pediatric acute hospitalization for anorexia nervosa: an economic evaluation Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-27 Maria Rosaria Marchili, Elena Bozzola, Stefano Guolo, Silvio Marchesani, Giulia Spina, Cristina Mascolo, Stefano Vicari, Isabella Tarissi De Jacobis, Massimiliano Raponi, Alberto Villani
Anorexia nervosa (AN) is a psychiatric disorders which may potentially led to a high risk of health medical complications, suicide and self-harming behaviour. Since Covid-19 pandemic onset in March 2020, evidence suggested an increase occurrence of AN. The main aim of the retrospective analysis is to define the cost of hospitalization in the acute phase (HAP) at IRCCS Bambino Gesù Children Hospital
-
Use of Remdesivir in children with COVID-19: report of an Italian multicenter study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-27 Lorenza Romani, Marco Roversi, Stefania Bernardi, Elisabetta Venturini, Silvia Garazzino, Daniele Donà, Andrzej Krzysztofiak, Carlotta Montagnani, Elisa Funiciello, Francesca Ippolita Calò Carducci, Caterina Marabotto, Elio Castagnola, Filippo Salvini, Laura Lancella, Andrea Lo Vecchio, Luisa Galli, Guido Castelli Gattinara
COVID-19 is generally milder in children than in adults, however severe infection has been described in some patients. Few data are available on use of Remdesivir (RDV) in children, as most clinical trials focused on adult patients. We report a multicenter study conducted in 10 Italian Hospitals to investigate the safety of RDV in children affected by COVID-19. We collected the clinical data of children
-
Prevalence of extended-spectrum beta-lactamase and molecular detection of blaTEM, blaSHV, and blaCTX-M genotypes among gram-negative Bacilli isolates from hospital acquired infections in pediatrics, one institutional study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-24 Ahmed Gomaa Ahmed Elsayed, Dina F. Badr, Nermene Youssef Abo El Kheir, Maysaa El Sayed Zaki, Abdelrahman Eid Mahmoud Mossad, Ehab Mohammed Fahmy Mahmoud
Gram-negative bacilli represents an important pathogen in hospital-acquired infections (HAIs) worldwide. The emergence of antibiotic resistance in these pathogens warrants attention for the proper management of infections. Extended-spectrum beta-lactamase (ESBL) resistance represents a major therapeutic problem in infections due to Gram-negative bacilli. The present study aimed to study the extended-spectrum
-
Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-16 Antonio Corsello, Gregorio Paolo Milani, Marina Picca, Roberto Buzzetti, Romeo Carrozzo, Mirko Gambino, Giovanni Chiaffoni, Paola Marchisio, Chiara Mameli
Recurrent Upper Respiratory Tract Infections (R-URTIs) pose a significant challenge in pediatric healthcare, affecting both children and their families. This study aimed to investigate the prevalence, risk factors, and clinical implications of R-URTI in children aged 0–5 years. This observational study involved a sample of 483 children aged 0–5 years, focusing on establishing a practical and dynamic
-
Record of strep throat infections in Italy: what is needed to know about penicillin allergy? The point of view from the Italian Society of Pediatric Allergy and Immunology (SIAIP) Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-14 Maria De Filippo, Angela Klain, Ilaria Brambilla, Silvia Caimmi, Riccardo Castagnoli, Cristiana Indolfi, Giulio Dinardo, Amelia Licari, Alberto Martelli, Maria Angela Tosca, Martina Votto, Gian Luigi Marseglia, Michele Miraglia del Giudice
Notifications of invasive group A streptococcal (iGAS) infections have significantly increased in many European Countries compared to the previous season. In Italy, there has been an increase in streptococcal pharyngitis and scarlet fever cases since January 2023, which sparked concerns about a GAS epidemic in the pediatric population. This rise may be ascribed to the GAS infection season that began
-
The mechanisms of milder clinical symptoms of COVID-19 in children compared to adults Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-14 Caiyin Luo, Wanwen Chen, Junying Cai, Yuwen He
In stark contrast to adult patients, children who contract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) typically manifest milder symptoms or remain asymptomatic. However, the precise underlying mechanisms of this pathogenesis remain elusive. In this review, we primarily retrospect the clinical characteristics of SARS-CoV-2 infection in children, and explore the factors that may contribute
-
Long-term effects of SARS-CoV-2 infection in hospitalized children: findings from an Italian single-center study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-14 Valeria Calcaterra, Veronica Maria Tagi, Enza D’Auria, Alessia Lai, Sara Zanelli, Chiara Montanari, Elia Maria Biganzoli, Giuseppe Marano, Elisa Borghi, Valentina Massa, Agostino Riva, Gianvincenzo Zuccotti
Limited evidence exists regarding the association between COVID-19 and Long COVID manifestations in children, particularly concerning variants of concern (VOCs). We aimed to characterize a cohort of pediatric patients hospitalized with confirmed acute SARS-CoV-2 and monitor them for Long COVID symptoms. Additionally, it seeks to explore any potential correlations between VOCs and clinical symptoms
-
Early brain cognitive development in late preterm infants: an event-related potential and resting EEG study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-14 Qinfen Zhang, Xuan Dong, Wenjie Jin, Jiaojiao Fan
Late preterm infants (LPIs) are at risk of neurodevelopmental delay. Research on their cognitive development is helpful for early intervention and follow-up. Event-related potential (ERP) and resting electroencephalography (RS-EEG) were used to study the brain cognitive function of LPIs in the early stage of life. The Gesell Developmental Scale (GDS) was used to track the neurodevelopmental status
-
Increased bronchiolitis burden and severity after the pandemic: a national multicentric study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-13 Sergio Ghirardo, Nicola Ullmann, Alessandro Zago, Michele Ghezzi, Marta Minute, Barbara Madini, Enza D’Auria, Cecilia Basile, Francesca Castelletti, Federica Chironi, Agata Capodiferro, Beatrice Andrenacci, Francesco Maria Risso, Salvatore Aversa, Laura Dotta, Antonella Coretti, Anna Chiara Vittucci, Raffaele Badolato, Alessandro Amaddeo, Egidio Barbi, Renato Cutrera
The coronavirus 2019 (COVID-19) related containment measures led to the disruption of all virus distribution. Bronchiolitis-related hospitalizations shrank during 2020–2021, rebounding to pre-pandemic numbers the following year. This study aims to describe the trend in bronchiolitis-related hospitalization this year, focusing on severity and viral epidemiology. We conducted a retrospective investigation
-
Risk factors and incidence of postoperative delirium after cardiac surgery in children: a systematic review and meta-analysis Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-08 Maoling Fu, Quan Yuan, Qiaoyue Yang, Wenshuai Song, Yaqi Yu, Ying Luo, Xiaoju Xiong, Genzhen Yu
Delirium, a form of acute cerebral dysfunction, is a common complication of postoperative cardiac surgery in children. It is strongly associated with adverse outcomes, including prolonged hospitalization, increased mortality, and cognitive dysfunction. This study aimed to identify risk factors and incidence of delirium after cardiac surgery in children to facilitate early identification of delirium
-
A retrospective analysis of acute kidney injury in children with post-COVID-19 multisystem inflammatory syndrome: insights into promising outcomes Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-05 Hanan El-Halaby, Riham Eid, Ahmed Elagamy, Ahmed El-Hussiny, Fatma Moustafa, Ayman Hammad, Mayada Zeid
Acute kidney injury (AKI) in patients with multisystem inflammatory syndrome (MIS), COVID-19 related infection has been increasingly recognized with a paucity of data on AKI incidence, related mortality, and the requirement of renal replacement therapy in children with MIS (MIS-C). This is a retrospective study evaluating the prevalence, severity, management and outcomes of AKI in a cohort of Egyptian
-
Risk factors and an early predictive model for Kawasaki disease shock syndrome in Chinese children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-03 Mingming Zhang, Congying Wang, Qirui Li, Hongmao Wang, Xiaohui Li
Kawasaki disease shock syndrome (KDSS), though rare, has increased risk for cardiovascular complications. Early diagnosis is crucial to improve the prognosis of KDSS patients. Our study aimed to identify risk factors and construct a predictive model for KDSS. This case-control study was conducted from June, 2015 to July, 2023 in two children’s hospitals in China. Children initially diagnosed with KDSS
-
Current hospital policies on breastfeeding: a survey from Italy Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Riccardo Davanzo, Laura Travan, Maria Lorella Giannì, Giuseppe Giordano, Silvia Perugi, Mariella Baldassarre, Antonella Soldi, Lorenzo Colombo, Isabella Mondello, Michela Pandullo, Alessia Ferrara, Elena Scarpato, Guglielmo Salvatori
The availability of an appropriate newborn feeding policy is an essential component of the promotion of breastfeeding in health facilities. The Italian Society of Neonatology (SIN) and the Italian Society of Paediatrics (SIP) have run an online survey among Maternity Hospitals to explore the existing breastfeeding policies and their characteristics. Between February and April 2023, an online survey
-
Demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage in different types of corpus callosum disorders: a comparative study in children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Ru-Huei Fu, Po-Yen Wu, I-Ching Chou, Chien-Heng Lin, Syuan-Yu Hong
This study aimed to investigate the demographic and clinical characteristics, types of seizure disorders, and antiepileptic drug usage among individuals with different types of corpus callosum disorders. A total of 73 individuals were included in the study and divided into three groups based on the type of corpus callosum abnormality: hypoplasia (H), agenesis (A), and dysgenesis (D). Demographic data
-
Acute otitis media diagnosis in childhood: still a problem in 2023? Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Francesco Folino, Marco Caruso, Pietro Bosi, Mirko Aldè, Sara Torretta, Paola Marchisio
Diagnosis of acute otitis media (AOM) in children can be challenging, given that symptoms are often non-specific or absent, and that the direct observation of the tympanic membrane in its entirety through otoscopy can sometimes be difficult. The aim of this study is to assess the diagnostic concordance in detection of AOM episodes between primary care paediatricians and physicians especially trained
-
New insight into the intravenous immunoglobulin treatment in Multisystem Inflammatory Syndrome in children and adults Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Chih-Jen Chen, Hsu-Yen Kao, Ching-Hua Huang, Chia-Jung Li, Cheng-Hsien Hung, Su-Boon Yong
Within 6 months of the coronavirus pandemic, a new disease entity associated with a multisystem hyperinflammation syndrome as a result of a previous infection with the SARS-CoV-2 virus is increasingly being identified in children termed Multisystem Inflammatory Syndrome in Children (MIS-C) and more recently in adults(MIS-A). Due to its clinical similarity with Kawasaki Disease, some institutions have
-
Visual and auditory attention defects in children with intermittent exotropia Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Cong Wei, Ding-Ping Yang, Yan Yang, Wen-Han Yang, Ya-Mei Lu, Xin-Ping Yu, Shuai Chang
Previous studies have shown that children with intermittent exotropia (IXT) have a higher rate of psychiatric abnormalities as they grow up, such as attention deficit. This study explored visual and hearing attention among children with IXT, and evaluated its association with clinical characteristics and cognitive development. Forty-nine children with a diagnosis of IXT and 29 children with traditional
-
Serum levels of PDGF-CC as a potential biomarker for the diagnosis of Kawasaki disease Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Jing Zhang, Penghui Yang, Yihao Liu, Zhuo Chen, Jinhui Wu, Siqi Feng, Qijian Yi
Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with angiogenic properties that has been amply demonstrated to play a critical role in the cardiovascular system. This study aimed to investigate the serum expression of PDGF-CC
-
Sharenting: hidden pitfalls of a new increasing trend– suggestions on an appropriate use of social media Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Antonio Gatto, Antonio Corsello, Pietro Ferrara
The term “sharenting”, defining the practice of sharing children’s photos on social media, has become widespread globally. This phenomenon introduces new risks for children, often overlooked by parents lacking experience or caution in protecting their children from potential harms. Parents share multimedia contents with positive intentions, but the lack of immediate risk perception prevails. An Italian
-
Association of dietary inflammatory index with obesity among children and adolescents in the United States NHANES cohort: a population-based study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-25 Lili Zhang, Huimin Peng, Yao Wang, Hongjun Ba
Childhood obesity has become a huge challenge to childhood health, and there is a lack of understanding about the relationship between dietary inflammatory index (DII) and childhood obesity. The main objective of this study was to analyze the potential link between DII and obesity among children and adolescents residing in the United States. A cross-sectional analysis was performed using data obtained
-
Gastrointestinal bleeding in children: diagnostic approach Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-23 Marisa Piccirillo, Valentina Pucinischi, Maurizio Mennini, Caterina Strisciuglio, Elsa Iannicelli, Maria Agostina Giallorenzi, Silvia Furio, Alessandro Ferretti, Pasquale Parisi, Giovanni Di Nardo
Different conditions may underlie gastrointestinal bleeding (GIB) in children. The estimated prevalence of GIB in children is 6.4%, with spontaneous resolution in approximately 80% of cases. Nonetheless, the initial approach plays a pivotal role in determining the prognosis. The priority is the stabilization of hemodynamic status, followed by a systematic diagnostic approach. GIB can originate from
-
Comparison of lung ultrasound and chest radiography for detecting pneumonia in children: a systematic review and meta-analysis Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-23 Yalong Yang, Yuexuan Wu, Wen Zhao
Lung ultrasound (LUS) is recommended as a reliable diagnostic alternative to chest X-ray (CXR) for detecting pneumonia in children. PubMed, Embase, and Cochrane Library databases were used to identify eligible studies from their inception until April 2023. The investigated diagnostic parameters included sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic
-
Vascular access challenges in hemodialysis children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-22 Doaa M. Salah, Fatina I. Fadel, Mohamed A. Abdel Mawla, Hesham NAbdel Mooty, Mohamed El Ghobashy, Amr M. Salem, Mohamed Gamal Fathallah, Eman Abobakr Abd Alazem
Hemodialysis (HD) success is dependent mainly on vascular access (VA). The aim of this study is to share the experience of Pediatric Nephrology Unit (PNU), Cairo University Children’s Hospital (CUCH), with VA-related obstacles in end stage kidney disease (ESKD) HD children. This is a retrospective analysis of VA related data of 187 ESKD children received regular HD over 3 year duration (2019–2021)
-
The epidemiology and the pathogen distribution of pediatric dacryocystitis in Chinese population 2017–2022 Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-22 Zhihong Sun, Mingchao Li, Huiqing Sun
Dacryocystitis is a common disease in pediatric ophthalmology. Analysis of basic information, flora distribution, and characteristics of information on drug-resistant bacteria in children with dacryocystitis for 6 years, providing evidence for ophthalmologic infection prevention and clinical management strategies. A retrospective cohort study was conducted to evaluate the demographics of dacryocystitis
-
Knowledge mapping of spastic cerebral palsy. A bibliometric analysis of global research (2000–2022) Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-18 Xing Wang, Siew Hoon Teh, Xing-hua Wang
Cerebral palsy (CP) is characterized by abnormal pronunciation, posture, and movement. Spastic CP accounts for more than 70% of all CP. To date, there has been no bibliometric analysis to summarize study on spastic CP. Here, we aim to conduct a bibliometric analysis of spastic CP to summarize this field's knowledge structure, research hotspots, and frontiers. Publications about spastic CP were searched
-
The reliability and quality of YouTube videos as a source of breath holding spell Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-18 Mehmet Semih Demirtas, Nurettin Alici
Breath holding spells (BHS) are an important non-epileptic condition that is common in childhood and causes concern to families. YouTube is a powerful social media tool for accessing diseases and information such as BHS in child health. The aim of the study was to measure of the quality and reliability levels of the videos published in English on BHS uploaded on YouTube. The key words “infant”, “cry”
-
The hidden scabies: a rare case of atypical Norwegian scabies, case report and literature review Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-17 Angela Mauro, Cristiana Colonna, Silvia Taranto, Vittoria Garella, Francesca Castelletti, Laura Giordano, Nicola Adriano Monzani, Luca Bernardo
Norwegian scabies is a rare dermatological manifestation that usually affects the most fragile populations, such as elderly and immunocompromised patients, and its diagnosis is quite complex, due to its low prevalence in the general population and because of a broad spectrum manifestation. Here we describe a rare case of Norwegian scabies that was previously misdiagnosed in a sixteen year old patient
-
Lung clearance index short-term variability in cystic fibrosis: a pre-post pulmonary exacerbation study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-17 Matteo De Marchis, Enza Montemitro, Alessandra Boni, Alessandra Federici, Daniele Di Giovanni, Luca Cristiani, Renato Cutrera, Alessandro G. Fiocchi
Multiple Breath washout (MBW) represents an important tool to detect early a possible pulmonary exacerbation especially in Cystic Fibrosis (CF) disease. Lung clearance index (LCI) is the most commonly reported multiple breath washout (MBW) index and in the last years was used as management measure for evaluation. Our aim was to analyze clinical utility of LCI index variability in pulmonary exacerbation
-
Infant mortality in Italy: large geographic and ethnic inequalities Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-17 Silvia Simeoni, Luisa Frova, Mario De Curtis
Neonatal and infant mortality rates are among the most significant indicators for assessing a country's healthcare and social development. This study examined the trends in neonatal, post-neonatal, and infant mortality in Italy from 2016 to 2020 and analysed differences between children of Italian and foreign parents based on areas of residence, as well as the leading causes of death. Special attention
-
Investigation of early literacy skills of preschool children with hearing loss Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-17 Pelin Pistav Akmese, Destina Sezgin Kucuk, Gulce Kirazli
Early literacy development is critical for children with hearing loss to develop literacy skills in the years to come. The aim of this study is to compare the early literacy skills of 60–72 months’ children with hearing loss to the results of children with normal hearing. A total of 40 children (20 children with hearing aid (HA) and 20 children with normal hearing (NH) were evaluated in the study.
-
Breastfeeding support among re-hospitalized young children: a survey from Italy Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-08 Elena Scarpato, Guglielmo Salvatori, Michelangelo Barbaglia, Deborah Casero, Teresa Cazzato, Veronica Righetti, Annamaria Staiano, Riccardo Davanzo
In 2021, the Task Force on Breastfeeding of the Italian Ministry of Health released a document calling for the provision of breastfeeding support in case of re-hospitalization of the child after birth. Since type and quality of breastfeeding support during re-hospitalization in Italian Pediatric Units (PUs) is largely unknown, the Breastfeeding Section of the Italian Society of Pediatrics (TASIP) conducted
-
The association between patent foramen ovale and unexplained syncope in pediatric patients Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-07 Runmei Zou, Shuo Wang, Ping Liu, Donghai Chen, Jun Yan, Hong Cai, Yuwen Wang, Cheng Wang
Patent foramen ovale (PFO) is associated with transient ischemia attack (TIA) or stroke, paradoxical embolism, and migraines. PFO closure decreases the recurrent incidence of cerebral ischemic events and reduces the incidence of syncope in adults. However, whether PFO is associated with syncope in pediatric patients has not been investigated. 1001 pediatric patients (aged 4 to 17 years, mean age 10
-
Short-term and medium-term clinical outcomes of multisystem inflammatory syndrome in children: a prospective observational cohort study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-01-04 Anastasia Glazyrina, Elena Zholobova, Ekaterina Iakovleva, Polina Bobkova, Ekaterina Krasnaya, Karina Kovygina, Olga Romanova, Oleg Blyuss, Konstantin Tutelman, Polina Petrova, Anastasiia Bairashevskaia, Mikhail Rumyantsev, Anatoliy A. Korsunskiy, Elena Kondrikova, Anzhelika Nargizyan, Valeriya Yusupova, Evgeniya Korobyants, Anna Sologub, Seda Kurbanova, Aleksandr Suvorov, Louise Sigfrid, Danilo Buonsenso
Even though the incidence of Multisystem Inflammatory Syndrome in children (MIS-C) is decreasing cases are still reported across the world. Studying the consequences of MIS-C enhances our understanding of the disease’s prognosis. The objective of this study was to assess short- and medium-term clinical outcomes of MIS-C. Prospective observational cohort study at Municipal Children’s Hospital Morozovskaya
-
Using the center of pressure movement analysis in evaluating spontaneous movements in infants: a comparative study with general movements assessment Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-20 Halil Ibrahim Celik, Ayse Yildiz, Ramazan Yildiz, Akmer Mutlu, Ruhi Soylu, Kivilcim Gucuyener, Aysu Duyan-Camurdan, Esin Koc, Eray Esra Onal, Bulent Elbasan
Researchers have attempted to automate the spontaneous movement assessment and have sought quantitative and objective methods over the past decade. The purpose of the study was to present a quantitative assessment method of spontaneous movement using center-of-pressure (COP) movement analysis. A total of 101 infants were included in the study. The infants were placed in the supine position on the force
-
Present and future are getting confused: are we equipped to face the technological revolution? Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-12 Giorgio Perilongo, Rino Agostiniani, Giovanni Corsello, Gianluigi Marseglia, Maurizio Muraca, Anna Maria Staiano, Gianvincenzo Zuccotti, Eugenio Baraldi
This is a commentary reporting the outcome of a workshop promoted by the Department of Woman’s and Child’s Health of the University of Padua (Italy) focused on the emerging issue of what seems to be the increasing agemone role of technology. Over the centuries, technology has always been at the service of science, with theoretical insights anticipating experimental proofs. Over the last decades, however
-
Retraction Note: Immune characteristics of children with autoimmune encephalitis and the correlation with a short-term prognosis Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-05 Jin-Yue Huang, Wen-Xuan Fan, Jing Meng, Chun-Quan Cai, Dong Li
Retraction Note: Italian Journal of Pediatrics (2022) 48:94 https://doi.org/10.1186/s13052-022-01247-0 The Editor-in-Chief has retracted this article at the request of the corresponding author Dong Li because the authors have become aware of a number of errors in the data presented. Dong Li agrees with this retraction. Jin-Yue Huang, Wen-Xuan Fan, Jing Meng and Chun-Quan Cai have not responded to correspondence
-
Prediction of asthma using a four-locus gene model including IL13, IL4, FCER1B, and ADRB2 in children of Kazak nationality Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-04 Shasha Bai, Jun Lu, Li Hua, Quanhua Liu, Mengxue Chen, Yutong Gu, Jianhua Zhang, Dongjun Ma, Yixiao Bao
To study whether the four locus gene model consisting of ADRB2 rs1042713, IL4 rs2243250, FCER1B rs569108 and L13 rs20541 can predict asthma of the Kazak children in Xinjiang, China. Four single nucleotide polymorphisms about the 4 genes were genotyped in asthma group and control group of Han children and Kazak children respectively. The frequencies of different genotypes and alleles were compared between
-
Novel insect-based child nutrition: the position of the nutritional committee of the Italian society of pediatric gastroenterology, hepatology and nutrition (SIGENP) Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-01 Lorenzo Norsa, Carlo Agostoni, Teresa Capriati, Angelo Campanozzi, Antonella Diamanti, Antonella Lezo, Paolo Gandullia, Maria Immacolata Spagnuolo, Claudio Romano
The European Union (EU) approved the placement on European market of insect-based novel foods. Those foods were defined safe for the consumption for all European population, including children. The nutrition committee of the Italian society of Paediatric Hepatology and Nutrition (SIGENP) performed literature research to understand benefits and risk of those use of those NF for Italian children. A special
-
Prevalence of depression and anxiety in patients with Tourette syndrome; 1997 to 2022: a systematic review and meta-analysis Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-01 Parvin Abbasi, Sepideh Tanhaie, Mohsen Kazeminia
Tourette Syndrome (TS) is a disorder in which the patient has a history of multiple motor and vocal tics. Depression and anxiety are common in these patients. The results of the studies show different prevalence of these disorders in patients with TS. So, the objective of the present study was to liken the prevalence of depression and anxiety in patients with TS by systematic review and meta-analysis
-
Infantile epileptic spasms syndrome: a cohort study of 88 children Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-12-01 Li-Hong Ren, Jing Zhang, Si-Xiu Li, Ping Liu, Hui Chen, Wenguang Hu
This study aimed to investigate and analyze the risk factors for non-etiology-specific infantile spasms (IS) and unrelieved clinical symptoms after treatment. Eighty-eight children with IS who were treated at our hospital from March 2018 to December 2021 were included in the study. The children were divided into etiology-specific (n = 46) and nonetiology-specific (n = 42) groups, based on the diagnostic
-
An Italian case series' description of thiamine responsive megaloblastic anemia syndrome: importance of early diagnosis and treatment Ital. J. Pediatr. (IF 3.6) Pub Date : 2023-11-30 Francesca Di Candia, Valentina Di Iorio, Nadia Tinto, Riccardo Bonfanti, Claudio Iovino, Francesco Maria Rosanio, Ludovica Fedi, Fernanda Iafusco, Francesca Arrigoni, Rita Malesci, Francesca Simonelli, Andrea Rigamonti, Adriana Franzese, Enza Mozzillo
Individuals with thiamine-responsive megaloblastic anemia (TRMA) mainly manifest macrocytic anemia, sensorineural deafness, ocular complications, and nonautoimmune diabetes. Macrocytic anemia and diabetes may be responsive to high-dosage thiamine treatment, in contrast to sensorineural deafness. Little is known about the efficacy of thiamine treatment on ocular manifestations. Our objective is to report