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Primary Intraosseous Granular Cell Tumor of the Sphenoid and Central Skull Base in a Pediatric Patient Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-02-12 Delaney Sheehan, Belinda Mantle, Ashley Kraft, Randall Craver, Christopher Arcement, Renee Gardner, Ellen Zakris, Daniel Nuss
Granular cell tumors occur in all ages and many anatomic sites. In the craniofacial region, they typically arise in soft tissue, not bone. We present a primary intra-osseous granular cell tumor of ...
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Cell Free Microbial DNA Utilization at a Children’s Hospital Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-02-12 Randall Craver, Stephanie Collier, Margot Anderson
Background: We investigated the utilization of cell free microbial DNA (cfDNA) at a Children’s Hospital. Materials and Methods: cfDNA results were assessed regarding the contribution to therapeutic...
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Neonatal Dermatopathology: A 10-Year Institutional Review Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-25 Allie Preston, Cynthia Lee, Martin Fernandez, Sophia Hendrick
Neonatal skin conditions are typically diagnosed through noninvasive methods. Few studies describe the spectrum of biopsy- evaluated neonatal skin lesions. We present our institutional experience w...
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The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-25 Yalım Benibol, Ayşe Mine Önenerk Men, Ali Ekber Hakalmaz, Nil Çomunoğlu, Gonca Topuzlu Tekant, Rahşan Özcan
We examined the relationship between proinflammatory cytokines that occur in the inflammatory reaction in the intestine in Hirschsprung disease (HD) and Hirschsprung-associated enterocolitis (HAEC)...
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Group B Streptococcus and Perinatality in the South of Tunisia: Epidemiology, Serotype Distribution, and Antibiotic Susceptibility Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-24 Rim Kharrat, Nourelhouda Ben Ayed, Sonia Ktari, Chiraz Regaieg, Sonda Mezghani, Nedia Hmida, Faouzia Mahjoubi, Abdellatif Gargouri, Adnene Hammami
In the lack of updated Tunisian epidemiological data, we sought to describe the epidemiology of Group B Streptococcus (GBS) in pregnant women and newborns.A retrospective analysis of GBS neonatal i...
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Role of a Pediatric Pathologist during and after a Disaster Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-24 Randall Craver
Published in Fetal and Pediatric Pathology (Vol. 43, No. 1, 2024)
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Magnitude and Determinants of Intestinal Parasites among Children under Five in Ethiopia During 2010–2023: A Systematic Review and Meta-Analysis Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-24 Abayeneh Girma, Amere Genet
Background: Intestinal parasitic infection (IPI) poses a serious public health threat across the globe, particularly in children in low- and middle-income countries like Ethiopia. This study was to...
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Methylation Status of IGF-Axis Genes in the Placenta of South Indian Neonates with Appropriate and Small for Gestational Age Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-24 Nithya M. N., Krishnappa J., Sheela S. R., Venkateswarlu Raavi
Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the met...
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Human Placenta and Evolving Insights into Pathological Changes of Preeclampsia: A Comprehensive Review of the Last Decade Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-24 Diana Maria Chiorean, Esra Cobankent Aytekin, Melinda-Ildiko Mitranovici, Sabin Gligore Turdean, Mirpooya Salehi Moharer, Ovidiu Simion Cotoi, Havva Serap Toru
The placenta, the foremost and multifaceted organ in fetal and maternal biology, is pivotal in facilitating optimal intrauterine fetal development. Remarkably, despite its paramount significance, t...
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Letter Regarding “Clinicopathological Analysis of Sturge–Weber Syndrome With Focal Cortical Dysplasia FCD IIIc” Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-24 Törehan Özer, Yonca Anik
Published in Fetal and Pediatric Pathology (Vol. 43, No. 1, 2024)
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Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-12 Maolin Liu, Jiandong Lu, Chengjun Yu, Jie Zhao, Ling Wang, Yang Hu, Long Chen, Rong Han, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu
Background Wilms tumor (WT) is highly curable, although anaplastic histology or relapse imparts a worse prognosis. Nephrogenic rests (NR) associated with a high risk of developing WT are abnormally...
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Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-11 Shuqi Li, Shuang Zheng, Xinyi Huang, Wenhui Zhang, Fang Liu, Qinghua Cao
Background: We evaluated CD30 and CD56 expression in lymphoblastic lymphoma (LBL) and correlated the results with clinicopathological features and prognosis. Methods: Immunohistochemical (IHC) stai...
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Standardizing Minimally Invasive Tissue Sampling of Postmortem Brain Using Bard Monopty Needle in Newborns with Neurological Injury Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-10 Athira Sreenivas, Leslie Lewis, Jayashree Purkayastha, Vani Lakshmi R, Mary Mathew
Minimally invasive tissue sampling of the brain in newborns using the Bard Monopty needle helps to diagnose various neurological conditions by obtaining relevant brain cores. We designed a modified...
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Congenital Ichthyosis: Current Approaches to Prenatal Diagnoses Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-10 Manahel Mahmood Alsabbagh
Congenital ichthyosis represents a wide spectrum of diseases. This article reviews prenatal testing for ichthyosis.We used pubmed.ncbi.nlm.nih.gov to search for 38 types of congenital ichthyosis co...
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Autopsy-Based Growth Charts May under-Detect Fetal Growth Restriction at Autopsy Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-08 Min Jung Kim, Jennifer A. Hutcheon, Anna F. Lee, Jessica Liauw
Background: Accurate identification of fetal growth restriction in fetal autopsy is critical for assessing causes of death. We examined the impact of using a chart derived from ultrasound measureme...
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Prenatal Diagnosis of Crossed Pulmonary Arteries with a Postnatal Diagnosis of CHARGE Syndrome Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-08 Funda Oztunc, Riza Madazli, Hakan Erenel, Didem Kaymak, Serpil Eraslan, Hulya Kayserili
Introduction: Crossed pulmonary arteries (CPA) is an abnormality in which the ostium of the left pulmonary artery is located rightward and the ostium of the right pulmonary artery is leftward. Case...
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Comparison of Afamin Values in Umbilical Cord Blood After Delivery in Pregnancies With and Without Gestational Diabetes Mellitus Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2024-01-08 Yasemin Dogan, Oguz Arslan, Berrin Oztas, Aylin Kurtali, Ayse Seda Daryal, Müzeyyen Dilsad Eser
Afamin is a protein that increases in gestational diabetes but its concentration in neonates hasn’t been investigated. Our objective is to compare cord blood afamin levels in neonates born to mothe...
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Restriction of Medically Indicated Abortions Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-12-26 Randall Craver
Published in Fetal and Pediatric Pathology (Ahead of Print, 2023)
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Placental Histopathologic Findings in Fetal Hereditary Pyropoikilocytosis after Undergoing Successful Intrauterine Transfusion Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-12-18 Anna Dar, Rachel Brancamp, Garrett S. Booth, Caitlin E. Hughes
Background: The available literature on intrauterine transfusion focuses largely on its application in fetal alloimmunization rather than hereditary red cell disorders, with limited illustration of...
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Molecular Prevalence and Genotype Distribution of Human Adenovirus in Iranian Children with Gastroenteritis Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Abdulhussain Kadhim Jwaziri, Mohammad Hadi Karbalaie Niya, Pegah Khales, Atefeh Kachooei, Milad Sabaei, Soheil Rahmani Fard, Ahmad Tavakoli
We determined the molecular prevalence and genotype distribution of human adenovirus (HAdV) among children under five years of age with gastroenteritis in Iran.One hundred stool samples from childr...
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ATP7B Gene Variant Profile İdentified by NGS in Wilson’s Disease Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Orhan Gorukmez, Taner Özgür, Ozlem Gorukmez, Ali Topak
Background: Wilson’s disease (WD) is a copper metabolism disorder caused by ATP7B gene mutations and shows an autosomal recessive pattern of inheritance. We aimed to contribute to the mutation prof...
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Pathologist Pediatric In-Patient Genetic Stewardship Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Randall Craver
Background: Costs for sendout genetic testing on in-patients are billed to the hospital. Turnaround times are several weeks, often extending past the inpatient hospitalization.Materials and Methods...
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Placental Histopathologic Findings in the Setting of Prenatally Diagnosed Major Congenital Heart Disease Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Shaimaa Rakha, Alhussein Ahmed Mohamed, Shaimaa M. Yussif
Objectives: Studies suggest an association between placenta and congenital heart disease (CHD). We evaluated placental pathologies associated with major CHD. Methods: A prospective study included f...
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The Importance of Sphingomyelin Phosphodiesterase Acid-Like 3b (SMPDL-3b) Levels in Kidney Biopsy Specimens of Children With Nephrotic Syndrome Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Muhammet Kaya, İlknur Girişgen, Nagihan Yalçın, Tülay Becerir, Hande Şenol, Gülsün Gülten, Selcuk Yüksel
It remains unclear whether the low amount of SMPDL-3b required for rituximab binding is the cause of treatment resistance in patients with treatment-resistant nephrotic syndrome with advanced podoc...
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The Placenta and Neonatal Encephalopathy with a Focus on Hypoxic-Ischemic Encephalopathy Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Louis P. Dehner
Background: Placental examination is important for its diagnostic immediacy to correlate with maternal and/or fetal complications and parturitional difficulties. In a broader context, clinicopathol...
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Prenatal Array-CGH Detection of 3q26.32q26.33 Interstitial Deletion Encompassing the SOX2 Gene: Ultrasound, Pathological, and Cytogenetic Findings Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-22 Maria Paola Bonasoni, Giuseppina Comitini, Mariangela Pati, Veronica Bizzarri, Veronica Barbieri, Maria Marinelli, Stefano Giuseppe Caraffi, Roberta Zuntini, Marzia Pollazzon, Andrea Palicelli, Livia Garavelli
Background: SOX2 disorders are associated with anophthalmia-esophageal-genital syndrome or microphthalmia, syndromic 3 (MCOPS3- # 206900). Case Report: We describe a third fetal case with a de novo...
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Partial Trisomy 4p Syndrome Diagnosed Prenatally Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-10 Kaouther Nasri, Nadia Ben Jamaa, Ines Ouertani, Nadia Boujelben
Introduction: Trisomy 4p is a lethal chromosomal disorder, resulting from segmental or full trisomy of the short arm of chromosome 4. Prenatal diagnosis may allow decisions on whether to continue o...
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Testicular Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type: A Case Report with Summary of Prior Published Cases Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-11-09 Md Mohin, Soumya Dey, Raktim Ray, Firdous Wasim Sk, Oindrila Das, Uttara Chatterjee
Testicular mixed germ cell tumor is common in the post-pubertal age, less so in prepuberty. There are only 3 reports of prepubertal mixed teratoma and yolk sac tumor. Two of these cases had immatur...
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Assessment of Matrix Metalloprotease – 7 (MMP7) Immunohistochemistry in Biliary Atresia and Other Pediatric Cholestatic Liver Diseases Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-10-31 Sandhya Biswal, Dipanwita Biswas, Santosh Kumar Mahalik, Suvendu Purkait, Suvradeep Mitra
Background and aims: Biliary atresia (BA) is a progressive fibro-obliterative cholangiopathy. The histopathological diagnosis is often challenging and an immunohistochemical marker is often sought ...
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Early Diagnosis of 46,XX Testicular Difference of Sexual Development: Unusual Presentation with Increased Nuchal Translucency Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-10-30 Miguel Saraiva, Vera M. F. Santos, Lina Ramos, Fabiana Ramos, Joana Serra-Caetano, Rita Cardoso, Isabel Dinis, Alice Mirante
46,XX testicular disorder of sexual development (DSD) may present prenatally as a mismatch between phenotype and karyotype. Enlarged nuchal translucency is an abnormal sign of many disorders. We pr...
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Ectopic Salivary Glands – a Differential Diagnosis to a Thyroglossal Duct Cyst Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-10-06 Thomas Menter, Stefan Holland-Cunz
Background: Midline developmental neck lesions primarily consist of thyroglossal duct remnants. Their recurrence is uncommon following thorough resection, which includes hyoid removal (the Sistrunk...
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The Frontal Phocomelia in a 3-Year-Old Girl Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-09-16 Martina Vidová Uğurbaş, René Hako, Miloš Kňazovický
Background: Phocomelia is a congenital limb deformity in which the proximal part of the upper or lower limb does not develop. Occasionally the malformed limb may be located ectopically. Case report...
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Placental Syphilis: A Comprehensive Review of Routine Histomorphology, HIV Co-infection, Penicillin Treatment, Immunohistochemistry, and Polymerase Chain Reaction Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-09-05 Yolandi Anne Marais, Deidré Mason, Annelize Barnard, Chestley Rashaell Saaiman, Hester Christine Els, Judith Kluge, Allison Joy Glass, Colleen Anne Wright, Pawel Tomasz Schubert
Introduction: Placental examination is valuable for diagnosing congenital syphilis, but the classic histological triad is not always observed. This study aimed to identify additional morphological ...
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Neurogenic Monodermal Teratoma in the Scapula of a Child: A Case Report Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-09-01 Xianping Jiang, Huan Zhang, Xifeng Du, Cailei Zhao, Qiuling Miao, Jianming Song
Background: Neurogenic monodermal teratomas (NMTs) have been reported in the ovaries but not from bone. Case Report: A 6-year-old girl had an incidentally discovered lesion in the right scapula. Up...
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Unifocal Type-3 Mixed Histiocytosis in a 10-Years Old Child Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-22 Arturo Bonometti
Histiocytoses patients present with highly heterogeneous clinical and histopathological pictures requiring multidisciplinary management. Mixed histiocytosis is a recently described group of syndrom...
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Giant Congenital Melanocytic Nevus with Congenital Neurofibroma: A Case Report Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-16 Atreyee Sarkar, Debalina Karmakar, Jayanta Kumar Saha, Kalyani Saha Basu, Uttara Chatterjee, Koushik Saha, Deepak K. Mishra
Giant congenital melanocytic nevus (GCMN) is characterized by its large size and potential for transformation into melanoma. It can be associated with other neural cristopathies, including neurofib...
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Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-14 Mustafa Sengul, Baris Karadas, Selin Acar-Sahan, Fatma Simsek, Ersan Horoz, Işık Cem Özok, Tijen Temiz
Objective: To investigate the relaxation responses mediated by L-type Ca2+ channels and big-conductance Ca2+-activated K+ (BKCa) channels and histological changes in the human umbilical artery (HUA...
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Assessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-12 Tess E.K. Cersonsky, George R. Saade, Robert M. Silver, Uma M. Reddy, Donald J. Dudley, Halit Pinar
Background: Previous studies identified microscopic changes associated with intrauterine retention of stillbirths based on clinical time of death. The objective of this study was to utilize unsuper...
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Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-07 Seyed Mahdi Hosseiniyan Khatibi, Yalda Rahbar Saadat, Seyyedeh Mina Hejazian, Simin Sharifi, Mohammadreza Ardalan, Mohammad Teshnehlab, Sepideh Zununi Vahed, Saeed Pirmoradi
Objective: Wilms tumor (WT) and Rhabdoid tumor (RT) are pediatric renal tumors and their differentiation is based on histopathological and molecular analysis. The present study aimed to introduce t...
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Yolk Sac Tumour Arising in the Glans Penis an Achondroplasic Child: A Case Report with Summary of Prior Published Cases Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-03 Sanjana Karan, Raktim Mukherjee, Pritam Singha Roy, Md. Mohin, Wasim Firdous, Uttara Chatterjee
Yolk sac tumors (YST) are commonly encountered gonadal germ cell tumors in children, especially in the prepubertal age group. In addition to gonadal primary, it can occur in multiple extragonadal s...
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Expression of GADD45B in Renal Tissue of Children with IgA Nephropathy and Correlation with Mesangial Hypercellularity Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-08-03 Chong Li, Ailing Wei, Yuanhan Qin
Background: We correlated the expression of growth arrest and DNA damage-inducible protein beta (GADD45B) in renal tissue with IgA nephropathy (IgAN) with clinical characteristics and mesangial hyp...
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Rearrangement of KMT2A Characterizes a Subset of Pediatric Parotid Mucoepidermoid Carcinomas Arising Metachronous to Acute Lymphoblastic Leukemia Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-07-30 Bacem K. Othman, Petr Steiner, Ilmo Leivo, Alena Skálová
Introduction: Metachronous mucoepidermoid carcinomas (MMEC) may occur in association with childhood leukemias and lymphomas. We compared molecular abnormalities of MMEC in patients with ALL with th...
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A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-06-27 Caner Kose, Busra Korpe, Kadriye Yakut Yucel, Ozgur Arat, Mevlut Bucak, Yaprak Engin Ustun
Purpose: This study investigated the Humanin levels in the umbilical cord blood of fetuses with late fetal growth restriction (FGR) and evaluated their association with perinatal outcomes. Materia...
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Erythromycin Attenuates Hyperoxia Induced Lung Injury by Enhancing GSH Expression and Inhibiting Expression of Inflammatory Cytokines Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-06-21 Xiaoyun Chu, Xiaoyue Zhang, Bowen Weng, Xiaotong Yin, Cheng Cai
Introduction: Oxidative stress and inflammation have proven to be key factors contributing to the occurrence of BPD. Erythromycin has been shown to be effective in treating the redox imbalance seen...
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Placental Pathology and Its Importance in Preterm Infants Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-06-21 Duygu Tugrul Ersak, Hakkı Şerbetçi, Bergen Laleli Koç, Özgür Kara, Şeyma Bütün Türk, Gülsüm Kadıoğlu Şimşek, Fuat Emre Canpolat, Özlem Moraloğlu Tekin, Dilek Şahin
We evaluated what placental pathologies were associated with adverse preterm births.Placental findings, classified according to the Amsterdam criteria, were correlated with infant outcomes. The fet...
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Can We Estimate Late-Onset Sepsis by Serial Methemoglobin Levels? An Observational Study in Preterm Neonates Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-06-15 Gonca Vardar, Turkay Rzayev, Kubra Gokce Tezel, Eren Ozek
Objective: To assess serial methemoglobin (MetHb) levels in preterm infants as a possible diagnostic method for late-onset sepsis (LOS). Methods: Preterm infants were assigned into two groups: thos...
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Chronic Myeloid Leukemia During Pregnancy with Placental Involvement: Case Report and Literature Review Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-06-06 Esra Çobankent Aytekin, M. Pooya Salehi Moharer, Ahmet Boduroglu, CemYaşar Sanhal, Havva Serap Toru
Introduction: Chronic myeloid leukemia (CML) occurrence during pregnancy is unusual due to the low prevalence of the disease in women of childbearing age, with only three reported cases. Case repor...
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Maternal Hypertension and Early-Onset Neonatal Neutropenia Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-06-05 Peter Joslyn, Evrim Oral, Anne Martin, Jeffrey Surcouf, Brian Barkemeyer
Objective: Maternal hypertension is considered a risk factor for early neonatal neutropenia. We sought to explore this relationship. Study Design: This retrospective cohort study compared initial n...
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SIX1 as a Novel Immunohistochemical Marker in the Differential Diagnosis of Rhabdomyosarcoma Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-05-24 Daniel Ehinger, Hanna Frostberg, Sofia Larsson, David Gisselsson
Background: Differential diagnosis of rhabdomyosarcoma (RMS) is challenging. Sineoculis homeobox homolog 1 (SIX1) is an oncogene involved in skeletal muscle differentiation. We compared protein exp...
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Clinical Presentations and Diagnostic Imaging of VACTERL Association Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-05-17 Gabriele Tonni, Çağla Koçak, Gianpaolo Grisolia, Giuseppe Rizzo, Edward Araujo Júnior, Heron Werner, Rodrigo Ruano, Waldo Sepulveda, Maria Paola Bonasoni, Mario Lituania, On behalf of the “International Perinatology Research Group (IPRG)”
Abstract Background: VACTERL association consists of Vertebral, Anorectal, Cardiac, Tracheo-Esophageal, Renal, and Limb defects. The diagnosis depends on the presence of at least three of these structural abnormalities. Methods: The clinical presentation and diagnostic prenatal imaging of VACTERL association are comprehensively reviewed. Results: The most common feature is a vertebral anomaly, found
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The Relationship Between Vitamin-D Deficiency and Protein Oxidation Among Obese Children Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-05-08 Ilknur Surucu Kara, Cuma Mertoglu, Gülsah Siranli, Yusuf Kemal Arslan, Gamze Gok, Ozcan Erel
Abstract Aim: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Methods: Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. Results: A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D
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Comparison of Prenatal and Postmortem Diagnoses from 251 Fetal Autopsies: High Rate of Placenta Pathologies, Low Rate of Discrepancies Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-05-02 Jan-Theile Suhren, Kais Hussein, Hans Kreipe, Nora Schaumann
Abstract Background: In cases of intrauterine fetal death (IUFD), autopsy and placenta pathology can provide additional information to sonographic findings. We assessed the frequency of prenatally missed relevant diagnoses. Materials and methods: A retrospective evaluation of fetal autopsies from 2006 to 2021 was performed and were classified as: i) agreement, ii) cases where autopsy revealed additional
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A Case of Intra-Amniotic Umbilical Vein Varices Misdiagnosed as an Omphalocele Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-04-18 Hayet Zitouni, Taycir Cheikhrouhou, Chiraz Regaieg, Afef Ben Thabet, Rim Kallel, Saloua Ammar, Tahya Sellami Boudawara, Nadia Hmida, Mahdi Ben Dhaou, Riadh Mhiri
Abstract Background: Intra-amniotic umbilical vein varices are characterized by a focal dilatation of the extra abdominal umbilical vein. Case report: We report a full-term baby female with extra-abdominal umbilical vein varices misdiagnosed clinically as an omphalocele. The umbilical vein was ligated and excised near the level of the liver. The infant died one day after surgery due to extrinsic compression
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Pathologic and Immunophenotypic Characterization of Syncytial Giant Cell Variant of Pediatric Hepatocellular Carcinoma. A Distinct Subtype Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-04-18 Mukul Vij, Jagadeesh Menon, Komalavalli Subbiah, Lexmi Priya Raju, Gowripriya Gowrisankar, Naresh Shanmugum, Ilankumaran Kaliamoorthy, Ashwin Rammohan, Mohamed Rela
Abstract Introduction Hepatocellular carcinoma (HCC) in pediatrics has a uniformly poor prognosis. Complete surgical resection or liver transplantation remain the only curative options. In contrast to adult HCC, literature on pediatric HCC is sparse and a majority of the distinct subtypes are undefined with regards to their histology, immunohistochemistry and prognosis. Case report Two infants, one
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Developmental Trends in Postnatal Thyroid Hormones and Thyroid Dysfunction in Preterm Infants Born at less than 34 weeks Gestation Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-04-13 Shaohong Chen, Xiaoyan Lu, Bicheng Yang, Jieru Wu, Hui Huang, Yang Zou, Wenyan Tang, Ping Xu, Yu Yang
Abstract Objectives To analyse the trends in thyroid function tests (TFT) in preterm infants, evaluate the frequency of thyroid dysfunction, and identify the factors that influence thyroid function. Methods The TFT results and risk factors for thyroid dysfunction in preterm infants with gestational ages (GA) between 25 and 34 weeks were analysed. Results In total, 535 infants were enrolled in this
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Elevated Expression of ADAMTS-12 in Maternal and Umbilical Cord Serum of Placenta Accreta Spectrum Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-04-11 Irmak Icen Taskin
Abstract Objective We investigated a disintegrin and metalloproteinase with thrombospondin type 1 motif-12 (ADAMTS-12) levels in both fetal umbilical cord and maternal blood of pairs diagnosed with placenta accreta spectrum (PAS). Method We analyzed ADAMTS-12 level by ELISA in 160 samples that included 30 control pairs (30 maternal and 30 umbilical cord serums), 20 pairs in the placenta previa (PP)
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Heart Disease Screening and False Hypoxemia in the Neonate Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-03-31 David Rabiço-Costa, Laura Leite-Almeida, Sara Geraldes Paulino, Nuno Santos, Ana Cristina Gomes, Gustavo Rocha
Abstract Background Screening for congenital heart diseases by pulse oximetry is used for the initial assessment of the neonate. Variants of hemoglobin F can compromise light absorbance, inducing erroneous results. Case report Two infants screened for congenital heart disease showed an asymptomatic low peripheral oxygen saturation. Arterial blood gases analysis revealed a normal arterial pressure of
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Phyllodes Tumor of the Bladder in a 2-Year-Old Boy – An Exceptional Finding Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-03-30 Taycir Cheikhrouhou, Mahdi Ben Dhaou, Slim Charfi, Manar Hbaieb, Mohamed Zouari, Hayet Zitouni, Tahya Sellami Boudawara, Riadh Mhiri
Abstract Background: Breast phyllodes tumor has a distinct histologic appearance. There are no pediatric phyllodes tumors of the bladder in English literature reported. Case report: A 2-year-old boy presented with a urinary infection and obstructive urinary symptoms. A 3-cm slow-growing bladder mass revealed by repeated transabdominal ultrasonography was initially considered a ureterocele. Cystoscopic
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Ectopic Salivary Gland – A Possible Differential Diagnosis of a Branchial Cleft Cyst Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-03-29 Thomas Menter, Stefan Holland-Cunz
Abstract Background: Branchial cleft cysts or fistulae are common in pediatric surgical pathology and are cured by surgery. Lesions in this area may not show the classical features of a cyst or duct lined by squamous or respiratory epithelium and other differential diagnoses should be considered. Case report: A seven-year-old otherwise healthy boy presented with bilateral swelling of the lower neck
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Synchronous Hepatoblastoma and Neuroblastoma in Two Chinese Infants Fetal Pediatr. Pathol. (IF 1.1) Pub Date : 2023-03-17 Bo Shao, Yi-zhen Wang, Yuan Fang, Jing Chu, Lian Chen, Le-Jian He
Abstract Background: Commonly, pediatric solid tumors occur independently. Only two patients with synchronous hepatoblastoma (HBL) and neuroblastoma (NBL) have been reported. Case reports: Two Chinese infants presented with abdominal mass at 10 and 8 months. Computed tomography (CT) scans in both revealed hepatic masses with additional mediastinal or adrenal masses. Pathology confirmed synchronous