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Real-world effectiveness of ustekinumab and vedolizumab in TNF-exposed pediatric patients with ulcerative colitis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-14 Perseus V Patel, Amy Zhang, Balu Bhasuran, Vignesh G Ravindranath, Melvin B Heyman, Sofia G Verstraete, Atul J Butte, Michael J Rosen, Vivek A Rudrapatna
Vedolizumab (VDZ) and ustekinumab (UST) are second-line treatments in pediatric patients with ulcerative colitis (UC) refractory to antitumor necrosis factor (anti-TNF) therapy. Pediatric studies comparing the effectiveness of these medications are lacking. Using a registry from ImproveCareNow (ICN), a global research network in pediatric inflammatory bowel disease, we compared the effectiveness of
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Endoscopic and histologic utility of transnasal endoscopy in pediatric eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-14 Eliana Shaul, Kanak V Kennedy, Zachary C Spergel, Shanaz Daneshdoost, Mark Mahon, Shivani Thanawala, Jonathan M Spergel, Benjamin Wilkins, Matthew J Ryan, Amanda B Muir
Unsedated transnasal endoscopy (TNE) is an alternative method of examining the esophageal mucosa in pediatric patients with eosinophilic esophagitis (EoE), reducing cost, time, and risk associated with frequent surveillance esophagogastroduodenoscopies (EGD). Adequacy of transnasal esophageal biopsies for the evaluation of eosinophilic esophagitis histologic scoring system (EoEHSS) has not yet been
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Longitudinal screening of HLA-risk and HLA-nonrisk children for celiac disease to age 15 years: CiPiS study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Michaela Boström, Charlotte Brundin, Sara Björck, Daniel Agardh
Autoantibodies against tissue transglutaminase (tTG) are serological markers of celiac disease. The aim was to study the applicability of human leukocyte antigen (HLA)-genotyping and tTG autoantibodies in the screening of celiac disease in a longitudinal birth cohort followed to age 15 years.
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Impact of COVID-19 on paediatric chronic intestinal failure: A tertiary care children's hospital experience. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Johannes Hilberath, Anna-Sophia Mast, Simon Scherer, Jörg Fuchs, Johannes Schulte, Ekkehard Sturm, Steven Warmann, Christoph Slavetinsky
Paediatric patients with intestinal failure (IF) are at risk for both gastrointestinal (GI) and systemic complications, thus depending on a functioning network of multidisciplinary care. Data on the clinical impact of coronavirus disease 2019 (COVID-19) or the pandemic-related restrictions are limited. We aimed to analyse the clinical course of COVID-19 in children with IF, and to evaluate the perceived
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Shear-wave elastography for monitoring Fontan-associated liver disease: A prospective cohort study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Rishi Bolia, Sara Alremawi, Charlton Noble, Robert Justo, Cameron Ward, Peter J Lewindon
The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The
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Measurement practices of alanine aminotransferase in children: Temporal changes and etiology for increased values. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Linnea Aitokari, Pauliina Hiltunen, Heini Huhtala, Kalle Kurppa, Laura Kivelä
Data on alanine aminotransferase (ALT) measurement practices and diagnoses associated with increased values are limited. We evaluated these issues by collecting ALT measurements from 1- to 16-year-old patients investigated in 1992-2018 in a tertiary center. Diagnoses were gathered in 2008-2018. Altogether 145,092 measurements from 28,118 children were taken 42% undergoing repeated testing. Testing
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Gluten-free diet adherence in pediatric celiac patients: Evaluating CDAT questionnaire and test for gluten detection in urine. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Carolina R Lins E Mello, Gisélia A P da Silva, Manuela T C Lins, Margarida M de C Antunes
This study aimed to evaluate the contributions of the Adapted Celiac Dietary Adherence Test (CDAT) and the Rapid Urinary Gluten Detection Test (u-GIP) in assessing gluten-free diet adherence in children and adolescents with celiac disease.
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Combination biologic therapy in pediatric inflammatory bowel disease: Safety and efficacy over a minimum 12-month follow-up period. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-13 Magdalena Wlazlo, Monika Meglicka, Anna Wiernicka, Marcin Osiecki, Malgorzata Matuszczyk, Jaroslaw Kierkus
The severe course of inflammatory bowel diseases (IBDs) refractory to advanced therapies in children results in the search for new therapeutic methods. The aim of this study was to evaluate the efficacy and safety of dual therapy with biologics in a cohort of children with IBD.
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Persistent and newly developed gastrointestinal symptoms after surgery for intestinal malrotation in children: Dysmotility or disorders of gut and brain interaction? J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Dhiren Patel, Darnna Banks, Bindi Hira, Madeline Ford, Lusine Ambartsumyan, Leonel Rodriguez
Surgery for intestinal malrotation (IM) aims to correct the defect and improve symptoms; however, many have persistent gastrointestinal (GI) symptoms postoperatively. We evaluated the incidence, clinical presentation, and long-term outcomes of children with surgically repaired IM and its possible association with disorders of gut and brain interaction (DGBI).
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Analysis of missed clinic visits, preferred languages, and telemedicine in a pediatric gastroenterology practice. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Bonnie Crume, Mohamed Suufi, Gloria Nabbosa, Lori Parker-Hartigan, Ashley McBride, Paul A Rufo, McGreggor Crowley
Previous studies have demonstrated a relationship between socioeconomic disparities and missed clinic visits (MCV). However, the relationship between patient-preferred language and MCVs, particularly with respect to telemedicine, remains relatively underexplored. We sought to characterize the associations between MCV and patient-level predictors, including preferred language, in a large single-center
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Nut consumption during pregnancy is associated with decreased risk of peer problems in 5-year-old Japanese children. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Mai Quynh Nguyen, Yoshihiro Miyake, Keiko Tanaka, Shizuka Hasuo, Yoshitaka Nakamura, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa
Nuts are nutrient-dense foods rich in unsaturated fatty acids, protein, dietary fiber, vitamins, and minerals. The present prebirth cohort study examined the association between maternal nut intake during pregnancy and the risk of childhood behavioral problems in 5-year-old Japanese children.
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A multicenter registry study on percutaneous electrical nerve field stimulation for pediatric disorders of gut-brain interaction. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Ashish Chogle, Khalil El-Chammas, Neha Santucci, Monica Grimm, Lev Dorfman, Kahleb Graham, Daniel R Kelly, Jason E Dranove, Rachel Rosen, Samuel Nurko, Joseph Croffie, Keshawadhana Balakrishnan, Eric H Chiou, Liyun Zhang, Pippa Simpson, Katja Karrento
Percutaneous electrical nerve field stimulation (PENFS) has demonstrated promise in single-center trials for pediatric abdominal pain-related disorders of gut-brain interaction (DGBI). Our aim was to explore efficacy of PENFS as standard therapy for DGBI in a registry involving multiple pediatric gastroenterology referral centers.
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Catheter salvage from central line-related bloodstream infections in pediatric intestinal failure. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-07 Catherine Larson-Nath, Linder Wendt, Riad Rahhal
Patients with intestinal failure require central venous access which puts them at risk for central line-associated bloodstream infections (CLABSI). Maintaining vascular patency is critical for this population to receive nutrition support. When CLABSIs occur line salvage can help maintain vascular access. The aim of this study is to assess factors associated with safe and successful central venous catheter
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Parental perspectives on pediatric inflammatory bowel disease: Unraveling concerns, and study participation willingness. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-01 Adi Eindor-Abarbanel, Noa Pinchevski, Tzippora Shalem, Netanel Agajany, Nimrod Ophir, Batya Weiss, Efrat Broide, Vered Richter
The impact of disease burden extends beyond pediatric inflammatory bowel disease (IBD) patients to include their parents. Previous studies, predating the biologic era, have highlighted parental concerns about potential side effects associated with IBD medications. However, there is a notable gap in the literature regarding parents' perceptions of clinical studies involving pediatric IBD patients. This
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Effect of lactase supplementation on infant colic: Systematic review of randomized controlled trials. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-03-01 Anna Kozłowska-Jalowska, Agata Stróżyk, Andrea Horvath, Hania Szajewska
To systematically review evidence on the efficacy and safety of using a lactase supplementation for managing infant colic. The MEDLINE, EMBASE, and Cochrane Library databases were searched (up to September 2023) for randomized controlled trials (RCTs) comparing oral lactase supplementation with placebo or no intervention in infants younger than 6 months old with infant colic. The risk of bias was assessed
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Proton pump inhibitors, antibiotics, and atopy increase the risk of eosinophilic esophagitis in children with esophageal atresia. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-26 Tiffany C Tang, Steven T Leach, Usha Krishnan
To determine whether proton pump inhibitor (PPI) exposure is associated with an increased risk of developing eosinophilic esophagitis (EoE) in children with esophageal atresia (EA).
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A serum-induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-23 T Hang Nghiem-Rao, Jethro S Johnson, Amy Pan, Samantha N Atkinson, Cynthia Behling, Pippa M Simpson, Mary L Holtz, George M Weinstock, Jeffrey B Schwimmer, Nita H Salzman
Pediatric nonalcoholic fatty liver disease (NAFLD) is a growing problem, but its underlying mechanisms are poorly understood. We used transcriptomic reporter cell assays to investigate differences in transcriptional signatures induced in hepatocyte reporter cells by the sera of children with and without NAFLD.
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The role of high-resolution impedance manometry to identify rumination syndrome in children with unexplained foregut symptoms. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-22 Maria Giovanna Puoti, Mark Safe, Nikhil Thapar, Teresa Di Chio, Elena Sofia Pieri, Kornilia Nikaki, Keith Lindley, Anna Rybak, Osvaldo Borrelli
Diagnosis of rumination syndrome (RS) relies on Rome IV criteria. Oesophageal high-resolution impedance manometry (HRIM) can objectively demonstrate the episodes of rumination, but its role in the diagnostic pathway is not yet established. We aimed to demonstrate the clinical contribution of this tool for the timely diagnosis of RS and diagnostic work-up of children with unexplained foregut symptoms
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Drawing the abdominal pain: A powerful tool to distinguish between organic and functional abdominal pain. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-22 Joachim Opp, Mia Schürmann, Andreas Jenke, Barbara Job
Abdominal pain (AP) in children imposes a large economic burden on the healthcare system. Currently, there are no reliable diagnostic tools to differentiate between organic and functional disorders. We hypothesized from previous research that the analysis of patients' graphic expression of subjective symptoms as well as their interactional behavior adds new ways to differentiate between functional
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Growth pattern of paediatric patients affected by cow milk protein allergy fed with rice hydrolyzed formula. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-20 Rita Nocerino, Serena Coppola, Laura Carucci, Franca Oglio, Marica Cozzolino, Antonio Masino, Gulsum Ozen, Margherita Farnetano, Roberto Berni Canani
Formulas made from hydrolyzed rice proteins (HRPF) are well-tolerated plant-based alternatives to cow's milk protein (CMP)-based formulas for the dietary management of paediatric patients with CMP allergy (CMPA). Growth in patients with CMPA fed with HRPF has been evaluated in several studies with conflicting results. The aim was to evaluate the growth pattern of children with CMPA over a 12-month
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A nomogram for predicting food allergy in infants with feeding problems and malnutrition. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-20 Fan Yang, Chunyan Zhou, Luanluan Li, Xirui Wang, Bin Wang, Yabin Hu, Yue Zhang, Chen Chen, Juan Li, Xiandan Yu
As oral food challenge (OFC) cannot be performed routinely in the general outpatient, this study aimed to construct a nomogram to predict the odds of food allergy in infants with idiopathic feeding problems and malnutrition.
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ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource-limited settings. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-18 Giuseppe Indolfi, Regino P Gonzalez-Peralta, Maureen M Jonas, Manal Hamdy-El Sayed, Björn Fischler, Etienne Sokal, Stefan Wirth, Emanuele Nicastro
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide, with more than three million viraemic adolescents and children. Treatment of adults with HCV infection and HCV-related liver disease has advanced considerably thanks to development and improvements in therapy. Direct-acting antiviral regimens are safe and effective. Three regimens with pangenotypic activity (gle
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Effect of maturation at birth on the clinical features of neonatal cow's milk protein allergy: A retrospective study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-14 Motomichi Nagafuji, Satoshi Fujiyama, Ryota Ishii, Michiru Shime, Toshinori Kitatsu, Yusuke Hoshino, Yu Kanai, Junichi Arai, Yayoi Miyazono, Hidetoshi Takada
Neonatal immune regulation transitions from fetal immunity and varies with maturation status, but its role in neonatal cow's milk protein allergy (CMPA) remains unknown. We studied the association between maturation status at birth and neonatal CMPA. Clinical and laboratory data of neonates presenting with CMPA symptoms were retrospectively collected from two tertiary hospitals. Patients were assessed
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Humoral immune response and safety of SARS-CoV-2 vaccination in very early onset inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-14 Arthur J Kastl, Kimberly N Weaver, Xian Zhang, Jennifer A Strople, Jeremy Adler, Judith R Kelsen, Marla C Dubinsky, Athos Bousvaros, Runa Watkins, Colin Dai, Raymond K Cross, Peter D R Higgins, Ryan Ungaro, Meenakshi Bewtra, Emanuelle A Bellaguarda, Francis A Farraye, Kelly Chun, Michael Zikry, Monique Bastidas, Margie E Boccieri, Ann Firestine, Millie D Long, Michael D Kappelman
Children with very early onset inflammatory bowel disease (VEO-IBD) may respond differently to coronavirus disease 2019 (COVID-19) immunization compared to healthy children or other patients with IBD. We recruited children with VEO-IBD <6 years of age and younger following receipt of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Demographics, IBD characteristics, medication
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Gut microbiota and inflammatory mediators differentiate IgE mediated and non-IgE mediated cases of cow's milk protein at diagnosis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-12 Ana M Castro, Isabel Gutiérrez-Díaz, María L Saiz, Sandra Navarro, Marta Suárez, Ignacio Carbajal, Águeda García, Lydia Sariego, Paula Toyos, Silvia Rodríguez, Santiago Jiménez, David González, Cristina Molinos, David Pérez, Porfirio Fernández, Beatriz Suárez-Alvarez, Abelardo Margolles, Juan J Díaz, Susana Delgado
Analyze fecal and blood samples at point of diagnosis in IgE mediated cow's milk protein allergy (CMPA) and non-IgE mediated (NIM)-CMPA patients to look for potential new biomarkers.
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Clinical outcomes and cost savings of a nonmedical switch to a biosimilar in children/young adults with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-09 Megan McNicol, Mahmoud Abdel-Rasoul, Madeline G McClinchie, Grant A Morris, Brendan Boyle, Jennifer L Dotson, Hilary K Michel, Ross M Maltz
The safety, efficacy, and cost savings associated with biosimilar medications are well established. However, a lack of pediatric data exists surrounding clinical outcomes when switching from an originator to a biosimilar. Our primary aim is to evaluate clinical outcomes following a nonmedical switch from the infliximab originator to a biosimilar in children and young adults with inflammatory bowel
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Real-world experience of maralixibat in Alagille syndrome: Novel findings outside of clinical trials. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-09 Ryan Himes, Philip Rosenthal, Natasha Dilwali, Kathryn Smith, Robert Venick, Regino P Gonzalez-Peralta
Maralixibat, an ileal bile acid transporter inhibitor, is the first drug approved by the U.S. Food and Drug Administration for the treatment of cholestatic pruritus in patients aged ≥3 months with Alagille syndrome (ALGS). Approval was based on reductions in pruritus from the pivotal ICONIC trial, information from two additional trials (ITCH and IMAGO), and long-term extension studies. Although participants
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Genetic and acquired sucrase-isomaltase deficiency: A clinical review. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-08 Tanaz Farzan Danialifar, Bruno P Chumpitazi, Devendra I Mehta, Carlo Di Lorenzo
Genetic sucrase-isomaltase deficiency (GSID) is an inherited deficiency in the ability to digest sucrose and potentially starch due to mutations in the sucrase-isomaltase (SI) gene. Congenital sucrase-isomaltase deficiency is historically considered to be a rare condition affecting infants with chronic diarrhea as exposure to dietary sucrose begins. Growing evidence suggests that individuals with SI
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Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology, United Kingdom 2022. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-08 Helen Callaby, Emma McGuire, Sanjay Rajwal, Jens Stahlschmidt, Jane Hartley, Rachel M Brown, Maesha Deheragoda, Alberto Quaglia, Tommy Rampling, Catherine F Houlihan, N Claire Gordon, Colin S Brown, Ruth Simmons, Anda Samson, Sema Mandal, Tassos Grammatikopoulos, Alicia Demirjian
In 2022, there were global reports of increased numbers of acute hepatitis not explained by hepatitis A-E virus infection in children. This manuscript summarises histopathology results from 20 patients in the United Kingdom who underwent liver transplant or had a liver biopsy as part of aetiological investigations. All available histopathological samples were reviewed centrally as part of the outbreak
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Iodine status in children with intestinal failure. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-07 Heitor Pons Leite, Eduardo Freitas Hatanaka, Giovana Sertori Galati Sabio, Nara Michelle de Araújo Evangelista, Maria Fernanda Carvalho de Camargo
Children on long-term parenteral nutrition (PN) are at high risk of iodine deficiency (ID). However, most available information comes from cross-sectional studies. We investigated the iodine status, associated factors, and prevalence of hypothyroidism in children with intestinal failure (IF) who were followed up longitudinally.
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Home-based fecal calprotectin utilization in a general pediatric gastroenterology clinic. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-06 Melanie L Schmidt, Emma McCrady, Angus Lee, Terrence Bowerbank, Michael R Miller, Melanie Watson, Ashok Dhandapani, Jessica P Woolfson, Andréanne N Zizzo, Kevin Bax, Eileen Crowley
Remote investigation and monitoring have gained importance in ambulatory practice. A home-based fecal calprotectin (FC) test has been developed where the sample is processed and analyzed at home through a smartphone application. We aimed to assess the use of standard ELISA (sFC) versus home-based (hFC) FC testing in a general pediatric gastroenterology clinic.
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Major basic protein is a useful marker to distinguish eosinophilic esophagitis from IBD-associated eosinophilia in children. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-05 Samantha Butzke, Shaida Nasiri-Blomgren, Diana Corao-Uribe, Zhaoping He, Zarela Molle-Rios
The incidence of eosinophilic esophagitis (EoE) is 3-5 times greater in patients with inflammatory bowel disease (IBD) compared with the general population. This study aimed to differentiate true EoE from esophageal eosinophilia in IBD patients by evaluating expression of major basic protein (MBP) and interleukin-13 (IL-13) in esophageal biopsies.
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Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-05 Engy S Elkaragy, Mohammed M Shamseya, Rasha H Metwally, Eman R Mansour, Sameh A Lashen
Adolescent and pediatric functional constipation (FC) is a common clinical problem. Currently, data on lubiprostone for the treatment of pediatric FC are scarce. This study investigated the efficacy and safety of lubiprostone in the treatment of pediatric FC.
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Measurement properties of the childhood bladder and bowel dysfunction questionnaire. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-05 Marieke L van Engelenburg-van Lonkhuyzen, Esther M J Bols, Caroline H G Bastiaenen, Rob A de Bie
The childhood bladder and bowel dysfunction questionnaire (CBBDQ) was previously found feasible, structurally valid, with good internal consistency. The purpose of this study was to evaluate the remaining measurement properties according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN).
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Characterization of pharyngeal contractile integral using pharyngeal manometry in children. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-05 Alisara Damrongmanee, Khalil El-Chammas, Neha Santucci, Lin Fei, Ajay Kaul
Pharyngeal contractile integral (PhCI) is the product of mean pharyngeal contractile amplitude, length, and duration, and provides a single metric for the vigor of entire pharyngeal contraction. A major limitation in children is lack of characterization of PhCI on high-resolution pharyngeal manometry. We aimed to determine and compare the values of PhCI in children with the abnormal and normal videofluoroscopic
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Differences in neonatal gastric tubes during insertion into a 3D model in relation to risk of potential perforation. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-02 Hilda-Brigitta Bartos, Sonja Diez, Alexander König, Jannis Görlach, Manuel Besendörfer, Andreas H Mahnken, Karla Drommelschmidt, Christel Weiss, Hanna Müller
Perforation of esophagus or stomach is a potential complication during and after insertion of a gastric tube in neonates. The aim of this study was to analyze different types of gastric tubes in a three-dimensional (3D) model of neonatal esophagus and stomach regarding potential perforations.
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Understanding the living-related pediatric liver transplantation donor's decision process: A questionnaire-based retrospective study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-01 Shalu Jain, Karunesh Kumar, Smita Malhotra, Arun Venuthurimilli, Neerav Goyal, Anupam Sibal
To analyse the donor characteristics and understand the sociocultural and familial aspects of the decision to donate for living donor liver transplant.
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Tissue markers may predict treatment response to antitumor necrosis factor-α agents in children with Crohn's disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-02-01 Alexander Krauthammer, Tal Cozacov, Sophia Fried, Adi Har-Zahav, Raanan Shamir, Amit Assa, Orith Waisbourd-Zinman
Patients with moderate-severe Crohn's disease (CD) who are treated with antitumor necrosis factor alpha (TNF-α) agents may be subjected to primary nonresponse or partial response. We aimed to identify tissue markers that may predict response to these agents.
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Towards a Standardized Classification of the Hepatobiliary Manifestations in Cystic Fibrosis (CFHBI): A Joint ESPGHAN/NASPGHAN Position Paper. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-1-31 Frank A J A Bodewes, Alvin Jay Freeman, Alexander Weymann, Dominique Debray, Isabelle Scheers, Henkjan J Verkade, Michael R Narkewicz
The broad spectrum of hepatobiliary involvement in cystic fibrosis (CF) has been commonly referred to as cystic fibrosis liver disease (CFLD). However, differences in the definitions of CFLD have led to variations in reported prevalence, incidence rates, and standardized recommendations for diagnosis and therapies. Harmonizing the description of the spectrum of hepatobiliary involvement in all people
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Gluten-free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-30 Veronica Luque, Paula Crespo-Escobar, Elin M Hård Af Segerstad, Tunde Koltai, Lorenzo Norsa, Enriqueta Roman, Anita Vreugdenhil, Ricardo Fueyo-Díaz, Carmen Ribes-Koninckx
Coeliac disease is a chronic, immune-mediated disorder for which the only treatment consists of lifelong strict adherence to gluten-free diet (GFD). However, there is a lack of evidence-based guidelines on the GFD dietary management of coeliac disease. This position paper, led by the Special Interest Group in coeliac disease of the European Society of Pediatric, Gastroenterology Hepatology, and Nutrition
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An observational study on the prevalence of choledochal cyst with pancreatitis: Geographical implications and management. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-30 Shalini G Hegde, Prassanna Venkatesh, Elaine A Mathew, Mallikarjun Patil, Prasanna Kumar
The objective of this study was to analyse the prevalence, risk factors and need for intervention in a sample of Indian children with choledochal cyst (CDC) complicated by pancreatitis with a special focus on chronic pancreatitis. A retrospective review of medical records of children admitted with CDC over 11 years was done and pancreatitis identified using INSPPIRE guidelines. Children were divided
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Nutritional status and feeding difficulties in children up to 2 years of age with cow's milk allergy. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-30 Piotr Dziechciarz, Agata Stróżyk, Andrea Horvath, Beata Cudowska, Urszula Jedynak-Wąsowicz, Nina Mól, Elżbieta Jarocka-Cyrta, Anna Zawadzka-Krajewska, Agnieszka Krauze
To assess the nutritional status and incidence of feeding difficulties in Polish children up to 2 years of age with cow's milk allergy (CMA) on cow's milk proteins-free diet.
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Complementary and alternative medicine (CAM) is frequently used by parents for the treatment of functional constipation in children. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-29 Jana Nelson, Steffi Mayer, Martina P Neininger, Astrid Bertsche, Martin Lacher, Jan-Hendrik Gosemann
Complementary and alternative medicine (CAM) has gained increasing attention as a supportive treatment for chronic diseases such as epilepsy, migraine, autism, and cancer in children. This study aimed to determine the frequency, motivation, and outcomes of CAM in children with functional constipation.
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Racial and ethnic differences in diagnosis age and blood biomarkers in a pediatric inflammatory bowel disease cohort. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-29 Keri M Kemp, Pooja K Nagaraj, Catheryn A Orihuela, Robin G Lorenz, Craig L Maynard, Jennifer S Pollock, Traci Jester
Prompt diagnosis of pediatric-onset inflammatory bowel disease (IBD) is crucial for preventing a complicated disease course; however, it is not well understood how social determinants of health might affect pediatric IBD diagnosis. This study examined differences in diagnosis age, biomarkers of disease severity, and anthropometrics with sociodemographic factors in a pediatric IBD cohort.
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Outcomes of children with constipation and autism spectrum disorder treated with antegrade continence enemas. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-29 Shruthi Srinivas, Ihab Halaweish, Maria E Knaus, Hira Ahmad, Kristine L Griffin, Kevin G Stephenson, Lina Yossef, Casey Trimble, Alberta L Negri Jimenez, Anan Lu, Alessandra Gasior, Richard J Wood, Kent C Williams
Treatment of functional constipation (FC) in children with autism spectrum disorder (ASD) is challenging due to sensory and behavioral issues. We aimed to understand whether antegrade continence enemas (ACEs) are successful in the treatment of FC in children with ASD.
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Anthropometric assessment: ESPGHAN quality of care survey from paediatric hospitals in 28 European countries. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-29 Anna Litwin, Thu Giang Le Thi, Rouzha Pancheva, Tena Niseteo, Almuthe Christina Hauer, Angelika Kindermann, Florence Lacaille, Emanuele Nicastro, Piotr Czubkowski, Katharina Ikrath, Konstantinos Gerasimidis, Sibylle Koletzko
Assessment of anthropometric data is essential for paediatric healthcare. We surveyed the implementation of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) evidence-based guidelines and practical recommendations on nutritional care, particularly regarding anthropometric measurements.
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Endoscopist experience with pediatric recurrent and intentional foreign body ingestion (RIFBI): Management considerations and future directions. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-29 Christina M Low Kapalu, Omar Uraizee, Diana G Lerner, Mike Thomson, Thomas Attard
Accidental foreign body ingestion (FBI) is a common pediatric referral concern. In contrast, recurrent and intentional FBI (RIFBI) is infrequent and associated with greater endoscopic and surgical intervention in adults. Although pediatric guidelines exist for FBI, the risk and therapeutic implications of RIFBI are not addressed. An anonymous international survey on pediatric gastroenterologist experience
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Proactive therapeutic drug monitoring and vedolizumab dose optimization in children with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-25 Patrick Rowland, Megan McNicol, Ashley Kiel, Ross M Maltz, Amy Donegan, Jennifer L Dotson, Hilary K Michel, Brendan Boyle
Therapeutic drug monitoring (TDM) and dose optimization have been shown to improve clinical outcomes with antitumor necrosis factor and recent studies in adults suggest an exposure-response relationship with drug levels associated with improved clinical outcomes. However, these levels are not universally recognized as therapeutic targets for vedolizumab dosing. We aimed to assess the impact of a TDM
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Prebiotics in the management of pediatric gastrointestinal disorders: Position paper of the ESPGHAN special interest group on gut microbiota and modifications. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-25 Flavia Indrio, Ener Cagri Dinleyici, Roberto Berni Canani, Magnus Domellöf, Ruggiero Francavilla, Alfredo Guarino, Pedro Gutierrez Castrellon, Rok Orel, Silvia Salvatore, Chris H P Van den Akker, Zvi Weizman
Prebiotics are substrates that are selectively utilized by host microorganisms conferring a health benefit. Compared to probiotics there are few studies with prebiotics in children. Most studies have been performed using infant formula supplemented with prebiotics, while add-on prebiotic supplementation as prevention or treatment of childhood gastrointestinal disorders has rarely been reported. The
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Nonpharmacological treatment of rumination syndrome in childhood: A systematic review of the literature. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-24 Roberta Sartori, Aurora Della Torca, Matteo Bramuzzo, Egidio Barbi, Antimo Tessitore
Rumination syndrome (RS) is a complex functional disorder characterized by recurrent, repetitive regurgitation of recently swallowed food. RS may have medical and psychosocial implications, compromising the quality of life and causing high rates of school absenteeism. Pediatric RS has been poorly studied and little evidence regarding its treatment is available. This systematic review aims to evaluate
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Proton pump inhibitors in esophageal atresia: A systematic review and meta-analysis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-23 Georges Dimitrov, Madeleine Aumar, Alain Duhamel, Mathilde Wanneveich, Frédéric Gottrand
Gastroesophageal reflux disease (GERD) is frequent and prolonged in esophageal atresia (EA) pediatric patients requiring routine use of proton pump inhibitors (PPIs). However, there are still controversies on the prophylactic use of PPIs and the efficacy of PPIs on GERD and EA complications in this special condition. The aim of the study is to assess the prophylactic use of PPIs in pediatric patients
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Percutaneous electrical nerve field stimulation for adolescents with irritable bowel syndrome: Cost-benefit and cost-minimization analysis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-15 Eric Shah, Shanti Eswaran, Kimberly Harer, Allen Lee, Borko Nojkov, Prashant Singh, William D Chey
Abdominal pain drives significant cost for adolescents with irritable bowel syndrome (IBS). We performed an economic analysis to estimate cost-savings for patients' families and healthcare insurance, and health outcomes, based on abdominal pain improvement with percutaneous electrical nerve field stimulation (PENFS) with IB-Stim® (Neuraxis). We constructed a Markov model with a 1-year time horizon
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Clinical performance of the infant nutrition early warning score in routine practice across four international clinical settings in Europe: A study by the ESPGHAN special interest group in clinical malnutrition. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-14 Omowunmi Bamkole, Koen Huysentruyt, Jennifer Watson, Nele De Mulder, Christina N Katsagoni, Despoina Chaloutsi, Michaela Kontostavlou, Rouzha Pancheva, Irina Vladimirova, Konstantinos Gerasimidis
There is a scarcity of nutritional screening tools for use in infants (<1 year). The infant Nutrition Early Warning Score (iNEWS) has been developed to identify infants who need further dietetic review. We introduced the iNEWS into clinical practice and evaluated its performance in Scotland, Belgium, Athens and Bulgaria. Of the 352 infants screened, 72 (20%) were placed in the high iNEWS category,
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Coexisting Th1 and Th2 cytokines in patients with collagenous gastritis and implications for its pathogenesis. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-09 Qingqing Liu, Yanping Wang, Noam Harpaz
Collagenous gastritis (CG) is a rare cause of refractory dyspepsia and anemia that frequently affects children and young adults and whose histological hallmark is chronic mucosal inflammation with a subepithelial collagen band. The etiology remains obscure, and no established treatments exist. We investigated the pathogenesis of CG by determining the expression profiles of genes related to immunity
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Efficacy of infliximab after loss of response of/intolerance to adalimumab in pediatric Crohn's disease: A retrospective multicenter cohort study of the "GETAID pédiatrique". J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-07 Anne Lecoutour, Claire Dupont, Dominique Caldari, Clémentine Dumant, Audrey Vanrenterghem, Mathias Ruiz, Rémi Duclaux-Loras, Stéphanie Berthet, Georges Dimitrov, Delphine Lacroix, Pauline Duvant, Céline Roman, Anne Claire Wagner, Aurélie Bourmaud, Jérôme Viala, Frank M Ruemmele, Bénédicte Pigneur
Infliximab (IFX) and adalimumab (ADA) are recommended for induction and maintenance of remission in pediatric Crohn's disease (CD). ADA is now often used in first line due to its efficacy and tolerability, but a loss of response (LOR) can occur over time. The aim was to assess the efficacy of IFX as second line therapy after LOR or intolerance to ADA in pediatric CD patients at 1 year.
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Using social media for patient care, research, and professional development: A North American society of pediatric gastroenterology, hepatology, and nutrition position paper. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-07 Jason A Silverman, Ankur Chugh, John M Hollier, Nicole Martin, Vikram K Raghu, Eduardo Rosas-Blum, Miranda A L van Tilburg, Priya Venkataraman-Rao, Rajitha D Venkatesh, Peter L Lu
The advent of social media has changed numerous aspects of modern life, with users developing and maintaining personal and professional relationships, following and sharing breaking news and importantly, searching for and disseminating health information and medical research. In the present paper, we reviewed available literature to outline the potential uses, pitfalls and impacts of social media for
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Impact of early immunosuppression on pediatric liver transplant outcomes within 1 year. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2024-01-02 Vikram K Raghu, Xingyu Zhang, James E Squires, Elizabeth Eisenberg, Amy G Feldman, Jennifer Halma, Anna L Peters, Regino P Gonzalez-Peralta, Vicky L Ng, Simon P Horslen, Steven J Lobritto, John Bucuvalas, George V Mazariegos, Emily R Perito
The Starzl Network for Excellence in Pediatric Transplantation identified optimizing immunosuppression (IS) as a priority practice improvement area for patients, families, and providers. We aimed to evaluate associations between clinical characteristics, early IS, and outcomes.
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Noninvasive scores are poorly predictive of histological fibrosis in paediatric fatty liver disease. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2023-12-29 Laura Kalveram, Ulrich Baumann, Ruth De Bruyne, Laura Draijer, Wojciech Janczyk, Deirdre Kelly, Bart G Koot, Florence Lacaille, Sander Lefere, Hadar Moran Lev, Judith Lubrecht, Jake P Mann, Antonella Mosca, Sanjay Rajwal, Piotr Socha, Anita Vreugdenhil, Anna Alisi, Christian A Hudert
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. Roughly a quarter of paediatric patients with NAFLD develop nonalcoholic steatohepatitis and fibrosis. Here, we evaluated the diagnostic accuracy of previously published noninvasive fibrosis scores to predict liver fibrosis in a large European cohort of paediatric patients with NAFLD.
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Terminology for discussing chronic pain: Using metaphors to educate families on chronic pediatric pain. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2023-12-27 Amber N Borucki, Cristina M Benki, Elisha E Peterson
To educate families about chronic pain requires a holistic discussion on the nature of pain, multidisciplinary treatment, and empowering families with tools to support their child's recovery.
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Diagnostic accuracy of multimodal noninvasive follow-up for pediatric ulcerative colitis: A single-center prospective study. J. Pediatr. Gastroenterol. Nutr. (IF 2.9) Pub Date : 2023-12-27 Vasiliki Spyropoulou, Giusy Russo, Eleonora Dei Rossi, Cosimo Ruggiero, Danila Volpe, Giulia D'Arcangelo, Paola Papoff, Fortunata Civitelli, Marina Aloi, Salvatore Oliva
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) often requiring endoscopic evaluations, which can be uncomfortable and costly, especially for children. This study aimed to evaluate the diagnostic accuracy of a noninvasive approach combining fecal calprotectin (FCP), colonic ultrasonography (US), and colon capsule endoscopy (CCE) compared with standard ileocolonoscopy in pediatric