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Leflunomide as adjunct therapy for BK viremia management in pediatric kidney transplant recipients Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-07 Alexandra Aldieri, Mary Chandran, Debora Matossian, Aparna Hariprasad, Bliss Magella, Danielle Lazear, Eliza Blanchette, Eric Benz, Margret Bock
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Unlocking the key: Delving into implicit bias in pediatric heart transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Carmel Bogle
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Management of pediatric patients with a failing kidney transplant: A survey of UK‐based renal units Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Matthew Letts, Zainab Arslan, Lucy Plumb, Pippa Bailey, Siân Griffin, Jelena Stojanovic
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Good outcomes after repeated pediatric liver retransplantations: A justified procedure even in times of organ shortage Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Henrik Junger, Birgit Knoppke, Leonhard Schurr, Frank W. Brennfleck, Dirk Grothues, Michael Melter, Edward K. Geissler, Hans J. Schlitt, Stefan M. Brunner, Markus Goetz
BackgroundPediatric liver transplantations generally represent advanced surgery for selected patients. In case of acute or chronic graft failure, biliary or vessel complications, a retransplantation (reLT) can be necessary. In these situations massive adhesions, critical patient condition or lack of good vessels for anastomosis often are problematic.MethodsBetween 2008 and 2021, 208 pediatric patients
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Should urinary CXCL10/creatinine be measured for kidney transplantation? Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Guido Filler, Ajay P. Sharma
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Determining analgesic efficacy and clinical benefits of bilateral continuous erector spinae plane blocks after pediatric liver transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Cheng‐Wen Li, Nong He, Fu‐Shan Xue
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Pharmacokinetics of Envarsus in pediatric kidney transplant recipients – phase 1 pilot conversion study Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Jon Jin Kim, Laura Lawless, David Marshall, Andrew Maxted, Andrew Lunn, Meeta Mallik, Alun Williams
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Living‐donor liver transplantation for methylmalonic acidemia patient with hepatocellular carcinoma: A case report and literature review Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Harunori Deguchi, Seisuke Sakamoto, Seiichi Shimizu, Akinari Fukuda, Hajime Uchida, Yusuke Yanagi, Toshimasa Nakao, Tasuku Kodama, Ryuji Komine, Kentaro Nishi, Koichi Kamei, Chizuko Haga, Takako Yoshioka, Kimikazu Matsumoto, Reiko Horikawa, Mureo Kasahara
BackgroundMethylmalonic acidemia (MMA) is an autosomal recessive disorder caused by defects in propionyl‐CoA (P‐CoA) catabolism; of note, liver neoplasms rarely occur as a long‐term complication of the disorder. Herein, we report the case of a patient with MMA and hepatocellular carcinoma (HCC) who was successfully treated with a living‐donor liver transplant (LDLT) following prior kidney transplantation
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Survival does not differ by annual center transplant volume—A Pediatric Heart Transplant Society Registry study Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 A. Marion Ybarra, Alicia M. Kamsheh, Matthew J. O'Connor, Seth A. Hollander, Maria Bano, Michelle Ploutz, Gabrielle Vaughn, Andrea Lambert, Michael Wallendorf, James Kirklin, Charles E. Canter
BackgroundThere are conflicting data regarding the relationship between center volume and outcomes in pediatric heart transplantation. Previous studies have not fully accounted for differences in case mix, particularly in high‐risk congenital heart disease (CHD) groups. We aimed to evaluate the relationship between center volume and outcomes using the Pediatric Heart Transplant Society (PHTS) Registry
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Applications of motivational interviewing in adolescent solid organ transplant Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Julie M. Gettings, Debra S. Lefkowitz
BackgroundAdolescence is a developmental period that is known for the highest risk of difficulties with adoption and maintenance of health behaviors for successful transplant. Motivational interviewing (MI) has been demonstrated to be an effective strategy in the management of modifiable factors impacting adherence in both adult transplant and analogous pediatric chronic illness populations.AimsThis
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Liver transplant for primary biliary tract neuroendocrine tumor in a nine‐year‐old girl Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Anjali Rai, Lauren Sproule, Tatianna Larman, Kiyoko Oshima, Daniel Rhee, Kenneth Ng, Elizabeth King, Douglas Mogul, Kathryn Lemberg
BackgroundNeuroendocrine tumors (NETs) are rare epithelial neoplasms that arise most commonly from the gastrointestinal tract. In pediatrics, the most common site of origin is in the appendix, with the liver being the most common site of metastasis. Neuroendocrine tumors arising from the biliary tract are extremely rare.MethodsWe describe a case of a nine‐year‐old girl who presented with obstructive
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Biodegradable biliary stents placement using a “kissing‐stent” technique for management of a recalcitrant stricture post‐live donor liver transplant Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Aleena Malik, Vicky L. Ng, Blayne A. Sayed, Asad Siddiqui, Dimitri A. Parra
BackgroundBiliary complications are common in pediatric liver transplant. Strictures resistant to interventional radiology procedures can be extremely challenging to manage and may result in the need of surgery or retransplantation.MethodsThis case report illustrates the use of biodegradable stents post left lateral segment live donor liver transplant in a pediatric patient with a recalcitrant chronic
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Kidney adolescent and young adult clinic: A transition model in Africa Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Zibya Barday, Bianca Davidson, Paul Harden, Zakira Mukuddem‐Sablay, Nicola Wearne, Erika S. W. Jones, Daley Cross, Mignon McCulloch
Adolescents and Young Adults (AYAs) with chronic kidney disease (CKD) have challenges unique to this developmental period, with increased rates of high‐risk behavior and non‐adherence to therapy which may impact the progression of kidney disease and their requirement for kidney replacement therapy (KRT). Successful transition of AYA patients are particularly important in low‐ and middle‐income countries
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Ten‐year follow‐up of cavoportal hemitransposition in pediatric liver transplantation for complete portomesenteric venous thrombosis: A case report and literature review Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 John O. Barron, Kadakkal Radhakrishnan, Christopher Coppa, Deborah Goldman, Vera Hupertz, Mike Leonis, Bijan Eghtesad, Koji Hashimoto
BackgroundPortal vein thrombosis is a potentially devastating complication following pediatric liver transplantation. In rare instances of complete portomesenteric thrombosis, cavoportal hemitransposition may provide graft inflow. Here we describe long‐term results following a case of pediatric cavoportal hemitransposition during liver transplantation and review the current pediatric literature.MethodsA
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Antibody‐mediated rejection (AMR) in pediatric lung transplantation—Current state and future directions Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Christian Benden, Kathryn A. Wikenheiser‐Brokamp
Lung transplantation is considered as the ultimate therapy for children with advanced pulmonary disease. International data show a median conditional 1‐year post‐transplantation survival of 9.1 years. Recently, antibody‐mediated rejection (AMR) has increasingly been recognized as an important cause of allograft dysfunction although pediatric reports are still scarce. Donor‐specific anti‐human leukocyte
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mTor‐inhibition within the first days after pediatric heart transplantation is a potentially safe option to prevent cardiac allograft vasculopathy Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Hannah Kreienbaum, Brigitte Stiller, Rouven Kubicki, Alexej Bobrowski, Johannes Kroll, Thilo Fleck
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The effect of socioeconomic status on pediatric heart transplant outcomes at a single institution between 2013 and 2022 Pediatr. Transplant. (IF 1.3) Pub Date : 2024-03-04 Allison Armstrong, Jane W. Liang, Danton Char, Seth A. Hollander, Kimberly A. Pyke‐Grimm
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How to choose a best kidney for pediatric kidney transplant recipients Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-29 Asha Moudgil, Amy Bobrowski
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Review on clinician bias and its impact on racial and socioeconomic disparities in pediatric heart transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-29 Shahnawaz Amdani, Jeffrey G. Gossett, Valerie Chepp, Simon Urschel, Alfred Asante‐Korang, Jarrod E. Dalton
This expert review seeks to highlight implicit bias in health care, transplant medicine, and pediatric heart transplantation to focus attention on the role these biases may play in the racial/ethnic and socioeconomic disparities noted in pediatric heart transplantation. This review breaks down the transplant decision making process to highlight points at which implicit bias may affect outcomes and
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Epstein Barr virus‐directed T‐cell therapy for refractory EBV‐PTLD in a toddler post Orthotopic heart transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-29 Emily Work, Dipankar Gupta, William B. Slayton, John Rees, John‐Anthony Coppola, Robert Seifert, Mark S. Bleiweis, Jeffrey P. Jacobs, Giles Peek, Joseph Philip, Alan Brock, Jose Hernandez Rivera, Kevin Sullivan, Sukumar Suguna Narasimhulu
Epstein–Barr Virus (EBV) is a ubiquitous herpes type virus that is associated with post‐transplant lymphoproliferative disorder (PTLD). Usual management includes reduction or cessation of immunosuppression and in some cases chemotherapy including rituximab. However, limited therapies are available if PTLD is refractory to rituximab. Several clinical trials have investigated the use of EBV‐directed
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Small‐for‐size syndrome in a 9.7 kg pediatric recipient with a whole liver graft Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-29 Haytham Maria, Pamela L. Valentino, Patrick J. Healey, Yong K. Kwon
BackgroundSmall‐for‐size syndrome (SFSS) in pediatric liver transplant recipients, particularly those weighing less than 10 kg, is rare. This report describes a case of a 15‐month‐old whole liver transplant recipient who suffered SFSS, and systematic literature review was performed to identify outcomes of such cases and potential risk factors for SFSS.Case PresentationA 15‐month‐old toddler with a
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Evaluation of valganciclovir's neutropenia risk in pediatric solid organ transplant recipients utilizing two dosing regimens Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-29 Avani Patel, Kevin Le, Natalia Panek
BackgroundValganciclovir is approved for cytomegalovirus prophylaxis in pediatrics using the Pescovitz algorithm. There are reports of valganciclovir overdoses in children with low body surface area and overestimated creatinine clearance utilizing this algorithm. This study compared the incidence of neutropenia and cytomegalovirus infection between the Pescovitz and weight‐based dosing algorithms.MethodsA
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Management of the sensitized pediatric renal transplant candidate Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-24 Dechu P. Puliyanda, Stanley C. Jordan
Kidney transplantation is the treatment of choice for patients with ESRD as it is associated with improved patient survival and better quality of life, especially in children. There are several barriers to a successful transplant including organ shortage, anatomic barriers, and immunologic barriers. One of the biggest immunologic barriers that precludes transplantation is sensitization, when patients
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Featured Cover Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-01 Jean de Ville de Goyet, Fabrizio di Francesco, Davide Cintorino, Kejd Bici, Diletta Dona, Pasquale Bonsignore, Salvatore Gruttadauria
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Featured Cover Pediatr. Transplant. (IF 1.3) Pub Date : 2024-02-01 Enric Lledo, Marina M. Tabbara, Angel Alvarez, Jayanthi Chandar, Javier González, Rodrigo Vianna, Gaetano Ciancio
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Comparison of tacrolimus vs. cyclosporine in pediatric hematopoietic stem cell transplantation for thalassemia Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Suleimen Zhumatayev, Koray Yalcin, Safiye Suna Celen, Irem Karaman, Hayriye Daloglu, Seda Ozturkmen, Vedat Uygun, Gulsun Karasu, Akif Yesilipek
Graft-versus-host disease (GvHD) is one of the leading causes of morbidity and mortality in patients undergoing allogeneic HSCT, and effective prevention of GvHD is critical for the success of the HSCT procedure. Calcineurin inhibitors (CNI) have been used for decades as the backbone of GvHD prophylaxis. In this study, the efficacy and safety of Cyclosporine A (CsA) and tacrolimus (TCR) were compared
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Improvement of survival after hematopoietic stem cell transplantation and trends at a pediatric transplantation center; a three-decade journey Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Gülay Sezgin, Yasemin Sofu Öner, Gül İnan, İlker Ünal, Ayşe Özkan, Serhan Küpeli, İbrahim Bayram, Atila Tanyeli
Advances in stem cell transplantation have resulted in improved outcomes.
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Comparing between HLA-matched sibling donor allogenic HSCT and non-sibling matched related donor allogenic HSCT outcome in pediatric patients; single center retrospective study Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Mohammed F. Essa, Sarah Alghazwani, Rodaina Abujoub, Shahbaz Memon, Mohammed Alkaiyat, Husam Ardah, Abdulrahman Alsultan
Extended family donor search other than siblings may yield an HLA matched donor in communities with high rate of consanguinity. The outcome of patients who are transplanted from non-sibling matched related donors (NS-MRD) including engraftment and graft versus host disease (GVHD) are scarce in comparison with matched sibling donor (MSD).
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Metastatic pulmonary calcifications after pediatric liver transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Megan Z. Chiu, Alex G. Cuenca, Donna C. Koo, Kayla Hartjes, Andrew Wehrman, Heung Bae Kim, Eliza J. Lee
Pulmonary calcification (PC) is a rare clinical entity observed following liver transplantation (LT). Most often identified in adults or in patients with concomitant renal failure, PC is rarely reported in children. While the clinical course of PC is largely benign, cases of progressive respiratory failure and death have been reported. Additionally, PC may mimic several other disease processes making
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Monitoring of adenoviremia in pediatric patients undergoing hematopoietic stem cell transplantation: Is it alone sufficient to predict adenoviral disease? Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Saliha Kanık Yüksek, Özlem Arman Bilir, Tuğba Erat, Belgin Gülhan, Şerife Mehtap Kanbur, Gülsüm İclal Bayhan, İkbal Ok Bozkaya, Aslınur Özkaya Parlakay, Namık Yaşar Özbek
We aimed to evaluate our pediatric HSCT recipients routinely monitored for adenoviremia and to determine the adequacy of this monitoring in predicting adenoviral disease (AD).
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Pretransplant malignancy in pediatrics is not a risk factor for renal graft failure Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Asher Mandel, Samuel G. Robinson, Benjamin Peticca, Tomas M. Prudencio, Sunil S. Karhadkar
In adults, pretransplant malignancy (PTM) negatively impacts patient survival due to immunosuppression regimens influencing post-transplantation tumor growth. Few reports investigate the outcomes of pediatric kidney transplantation with PTM. We compare transplant outcomes for pediatric patients with PTM to matched controls, including cancer types extending beyond Wilms tumor.
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Gastrointestinal complications in pediatric lung transplant recipients: Incidence, risk factors, and effects on patient outcomes Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Timothy Klouda, Morgan Ryan E, Jessica Brie Leonard, Dawn Freiberger, Levent Midyat, Suzanne Dahlberg, Rachel Rosen, Gary Visner
Gastrointestinal (GI) complications in lung transplant recipients can occur any time during the post-operative period, leading to prolonged morbidity and mortality. Despite the negative association between GI complications and patient outcomes, little is known about their incidence and risk factors for their development in pediatric lung transplant recipients.
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Finance, race, ethnicity, and spoken language impact clinical outcomes for children with acute liver failure Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-26 Johanna Ascher Bartlett, Sarah Barhouma, Sarah Bangerth, Valeria Mejia, Carly Weaver, Rohit Kohli, Juliet Emamaullee
Pediatric acute liver failure (PALF) is an emergency, necessitating prompt referral and management at an experienced liver transplant center. Social determinants of health (SDOH) drive healthcare disparities and can affect many aspects of disease presentation, access to care, and ultimately clinical outcomes. Potential associations between SDOH and PALF outcomes, including spontaneous recovery (SR)
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Combining living and deceased donation for pediatric first isolated liver transplantation: A win-win even in countries with high deceased donor donation rates Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-24 Jean de Ville de Goyet, Chiara Grimaldi, Fabrizio di Francesco, Kejd Bici, Diletta Dona, Davide Cintorino
Split and living donor liver transplantations are both key surgical strategies for development of pediatric liver transplant programs. Often, however, teams tend to prioritize only one preferentially.
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Live-attenuated vaccination for measles, mumps, and rubella in pediatric liver transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-24 Anne Keutler, Elke Lainka, Carsten Posovszky
Infections are a serious short- and long-term problem after pediatric organ transplantation. In immunocompromised patients, they can lead to transplant rejection or a severe course with a sometimes fatal outcome. Vaccination is an appropriate means of reducing morbidity and mortality caused by vaccine-preventable diseases. Unfortunately, due to the disease or its course, it is not always possible to
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Serum uric acid concentration is associated with lower glomerular filtration rate in children undergoing kidney transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-23 Helena Seibert, Aline Maria Luiz Pereira, José Osmar Medina Pestana, Paulo Cesar Koch Nogueira
The relationship between serum concentration of uric acid (UA) and chronic kidney disease is complex due to many confounding variables. There is currently debate over whether hyperuricemia acts as a marker of kidney disease or as an independent risk factor.
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Risk Index Predicts Pediatric Heart Allograft Non-Utilization Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-19 Jake Lynn, Tahir Malik, Ashley Montgomery, Anna Lang, Nikhil Shamapant, John Miggins, Spoorthi Kamepalli, John Goss, Abbas Rana
Children listed for heart transplantation face the highest waitlist mortality among all solid organ transplant patients (14%). Attempts at decreasing donor allograft non-utilization (41.5%) could potentially decrease waitlist mortality for pediatric heart transplant patients. Our aim was to quantify the non-utilization risk of pediatric donor heart allografts at the time of initial offering.
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Unrecognized opportunities: The landscape of pediatric kidney-paired donation in the United States Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-19 Jennifer Verbesey, Alvin G. Thomas, Amy D. Waterman, Sunil Karhadkar, Victoria R. Cassell, Dorry L. Segev, Julien Hogan, Matt Cooper
Pediatric (age < 18 years) kidney transplant (KT) candidates face increasingly complex choices. The 2014 kidney allocation system nearly doubled wait times for pediatric recipients. Given longer wait times and new ways to optimize compatibility, more pediatric candidates may consider kidney-paired donation (KPD). Motivated by this shift and the potential impact of innovations in KPD practice, we studied
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Anti-spike antibody durability after SARS-CoV-2 vaccination in adolescent solid organ transplant recipients Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-19 John McAteer, Divya D. Kalluri, Rivka R. Abedon, Caroline X. Qin, Scott R. Auerbach, Olga Charnaya, Lara A. Danziger-Isakov, Noelle H. Ebel, Amy G. Feldman, Evelyn K. Hsu, Saeed Mohammad, Emily R. Perito, Ashley M. Thomas, Teresa P. Y. Chiang, Jacqueline M. Garonzik-Wang, Dorry L. Segev, William A. Werbel, Douglas B. Mogul
Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID-19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long-term antibody durability beyond this timeframe following three doses of the SARS-CoV-2 mRNA vaccine remains unknown. We describe antibody responses 6 months following the third vaccine dose (D3) of the BNT162b2
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Challenges faced in establishing a pediatric liver transplant program in a lower-middle-income country with free healthcare service Pediatr. Transplant. (IF 1.3) Pub Date : 2024-01-19 Meranthi Fernando, Suchintha Tillakaratne, Bhagya Gunetilleke, Chamila Liyanage, Chinthaka Appuhamy, Aruna Weerasuriya, Buddhika Uragoda, Nadeeshya Welikala, Liyanage Ranaweera, Eranga Ganewatte, Janaki Dissanayake, Anushka Mudalige, Rohan Siriwardana
Liver transplant is the cure for children with liver failure. Sri Lanka is a lower-middle-income country with a predominant free, state health system. Pediatric liver transplant program in Sri Lanka is still in the budding state where the initial experience of the program is yet to be documented.
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Changes in graft outcomes in recipients <10 kg over 25 years of pediatric kidney transplantation in the United States Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 Stella Kilduff, Benjamin Steinman, Nicole Hayde
Kidney transplant (KT) was initially associated with poor outcomes, especially in smaller recipients. However, pediatric transplantation has evolved considerably over time. We investigated the impact of weight at the time of transplant and whether outcomes changed over 25 years for <10 kg recipients.
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Considerations for liver transplantation in deoxyguanosine kinase deficiency: A case series and review of the literature Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 Jennifer T. Duong, M. Cristina Pacheco, Evelyn Hsu, Niviann Blondet
Deoxyguanosine kinase (DGUOK) deficiency is a rare mitochondrial disorder characterized by early onset liver failure and varying degrees of neurologic dysfunction. Patients typically present during infancy with progressive hepatic dysfunction leading to liver failure, which can precede neurologic deterioration. Outcomes posttransplantation are historically worse than average and the role of liver transplantation
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Heart disease symptoms and health-related quality of life in pediatric heart transplant recipients: A serial multiple mediator analysis Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 James W. Varni, Karen Uzark
A serial multiple mediator analysis was conducted to test the predictive effects of heart disease symptoms on pediatric heart transplant recipients health-related quality of life (HRQOL) from their perspective with patient-perceived cognitive problems, patient health communication, and treatment anxiety as hypothesized mediators.
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Liver transplantation in patient with Berardinelli–Seip syndrome: A literature review and case report Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 Altay Aliyev, Elgun Samadov, Arturan Ibrahimli, Akbar Hajiyev, Gunay Allahverdiyeva, Eldar Ahmadov
Berardinelli–Seip syndrome is an infrequently seen and potentially fatal genetic disorder characterized by the absence of adipose tissue. Herein, we report a first-in-literature liver transplant done on a 7-year-old girl because of liver cirrhosis caused by the Berardinelli–Seip syndrome.
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SCYL1 deficiency: A rare entity with challenging neurological manifestations after liver transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 Khaled Warasnhe, Figen Özçay, Esra Kılıç, Taner Sezer, Mehmet Haberal
Pediatric acute liver failure (PALF) with undetermined etiology is associated with higher liver transplantation and lower spontaneous recovery (transplant-free) rates. The diagnostic odyssey in PALF cases hinders appropriate management and follow-up after liver transplantation. Advances in whole exome sequencing analysis have already been successful at identifying new genetic causes of PALF.
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Prevalence and spectrum of infectious and inflammatory dermatologic conditions occurring in pediatric heart transplant patients on a predominantly mTOR-based immune suppressive regimen: A retrospective chart review Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 Ann Rydberg, Rebecca Ameduri, Trista Brown, Jonathan N. Johnson, Austin Todd, Megha M. Tollefson, Katelyn Anderson
Pediatric heart transplant patients are routinely followed in dermatology clinics due to elevated risk of cutaneous malignancy. However, transplant patients may experience other, non-cancer-related dermatologic conditions including skin infections, inflammatory diseases, and drug eruptions that can cause significant medical and psychosocial comorbidity.
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A longitudinal study of long-term renal outcome after pediatric liver transplantation in relation to CNI exposure Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-27 Simon Vandewiele, Jean Herman, Lambert van den Heuvel, Noël Knops
Chronic kidney disease (CKD) is reported in 20%–30% of children after liver transplantation (LT). One of the proposed underlying causes is the long-term exposure to tacrolimus, a calcineurin inhibitor (CNI), which is the main immunosuppressive drug used after LT. Variation in tacrolimus absolute exposure and relative dose requirements are believed to be important risk factors for developing CNI-associated
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The distribution of intestinal flora after hematopoietic stem cell transplantation in children Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-26 Lin Tong, Yan Meng, Luying Zhang, Jie Yu, Ying Dou
This prospective study aimed to comprehensively understand the changes in intestinal flora at different stages after hematopoietic stem cell transplantation (HSCT) in pediatric patients and to analyze the effect of intestinal flora on acute graft versus host disease (aGVHD), especially on gastrointestinal graft versus host disease (GI GVHD).
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Pediatric heart transplantation: Looking forward after five decades of learning Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-08 Anne I. Dipchand, Steven A. Webber
Heart transplantation has become the standard of care for pediatric patients with end-stage heart disease throughout the world. Since the first transplant was performed in 1967, the number of transplants has grown dramatically with 13 449 pediatric heart transplants being reported to The International Society of Heart and Lung Transplant (ISHLT) between January 1992 and June 30, 2018. Outcomes have
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Cardiac magnetic resonance imaging in detection of progressive graft dysfunction in pediatric heart transplantation Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-08 Kae Watanabe, Nicoleta C. Arva, Joshua D. Robinson, Cynthia Rigsby, Michael Markl, Melanie Sojka, Paul Tannous, Jennifer Arzu, Nazia Husain
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Effect of serum panel reactive antibodies on allogeneic hematopoietic stem cell transplantation in pediatric thalassemia patients: A single-center experience Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-08 Baris Malbora, Hakan Sarbay, Zeynep Dogusan, Abdullah Avni Atay
The aim of this study was to assess the impact of serum panel reactive antibodies (PRA) on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric thalassemia patients.
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Immediate extubation after pediatric liver transplantation: Update on a single-center experience Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-07 P. Nina Scalise, Donna C. Koo, Steven J. Staffa, Alex G. Cuenca, Pete G. Kovatsis, Heung Bae Kim, Eliza J. Lee
Immediate extubation (IE) following liver transplantation (LT) is increasingly common in adult patients. This study reviews our center's experience with IE in children following LT to determine characteristics predictive of successful IE and its effects on post-operative outcomes.
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Combined liver-kidney transplantation in pediatric patients Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-07 Nam-Joon Yi, Jiyoung Kim, Su Young Hong, Hee Gyung Kang
Combined liver-kidney transplantation (CLKT) is a surgical procedure that involves transplanting both liver and kidney organs. There are two types of CLKT: simultaneous liver-kidney transplantation (smLKT) and sequential LKT (sqLKT). CLKT accounts for a small percentage of liver transplantations (LTs), particularly in pediatric cases. Nevertheless, the procedure has demonstrated excellent outcomes
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Changes over time in self-efficacy and the allocation of responsibility for health management tasks in pediatric liver transplant recipients: Targets to improve the transition process Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-07 Jacob L. Bilhartz, M. James Lopez, Sally J. Eder, John C. Magee, Kelly Rea, Julie Sturza, Emily M. Fredericks
The process of transition to adult-based care encompasses a critical period in the life of an adolescent and young adult living with a chronic illness and one that comes with an increase in the risk of poor health outcomes. As yet, there is a dearth of empirical data to help optimize this process to ensure the best long-term outcome.
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Improving pediatric donor heart utilization: The less we change, the more things will stay the same Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-06 Seth A. Hollander
CONFLICT OF INTEREST STATEMENT Dr. Hollander has no conflicts of interests to disclose.
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Pediatric living donor liver transplant for Budd–Chiari syndrome using a cryopreserved pulmonary vein graft for retro-hepatic vena cava reconstruction: A case report Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-06 Xin Yu Yang, Annie Le-Nguyen, Fernando Alvarez, Zhi Xia Rong, Daniel Borsuk, Nelson Piché, Michel Lallier, Mona Beaunoyer
In pediatric patients with Budd–Chiari syndrome (BCS), living donor liver transplantation (LDLT) raises substantial challenges regarding IVC reconstruction.
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A fluid relationship: Calcineurin inhibitors and pericardial effusions Pediatr. Transplant. (IF 1.3) Pub Date : 2023-12-01 Mark Lee Westbroek, Mahvish Qureshi Rahim, Michael Marshall Ross, April Leigh Rahrig
Hematopoietic stem cell transplantation (HSCT) is a common and effective treatment for multiple malignant and non-malignant pediatric conditions. Graft-versus-host disease (GVHD) is a common complication of HSCT that can be prevented with prophylactic use of calcineurin inhibitor (CNI) immunosuppressants. A complication of HSCT and CNI use is pericardial effusion (PEF), which is frequently treated
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Liver histology and hepatic progenitor cell activity in pediatric acute liver failure: Implications for clinical outcome Pediatr. Transplant. (IF 1.3) Pub Date : 2023-11-30 Kalpana Panda, Vikrant Sood, Bikrant Bihari Lal, Rajeev Khanna, Archana Rastogi, Gayatri Ramakrishna, Seema Alam
Hepatic progenitor cell (HPC) activity and regenerative process that follows pediatric acute liver failure (PALF) is still not well understood. This clinicopathological study was thus conducted with an aim to study the correlation of liver histology and HPC activity with outcomes in PALF.
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Trends in sedation-analgesia practices in pediatric liver transplant patients admitted postoperatively to the pediatric intensive care unit: An analysis of data from the pediatric health information system (PHIS) database Pediatr. Transplant. (IF 1.3) Pub Date : 2023-11-28 Matthew Goldstein, Andrew Jergel, Saul Karpen, Zhulin He, Thomas M. Austin, Matt Hall, Akash Deep, Laura Gilbertson, Pradip Kamat
Children admitted to the pediatric intensive care unit (PICU), after liver transplantation, frequently require analgesia and sedation in the immediate postoperative period. Our objective was to assess trends and variations in sedation and analgesia used in this cohort.
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A New Regional Pediatric Heart Transplant Service: new program, current expectations. Pediatr. Transplant. (IF 1.3) Pub Date : 2023-11-27 Philip Roberts,Julian Ayer