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Benralizumab in children with severe eosinophilic asthma: Pharmacokinetics and long-term safety (TATE study) Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-16 H. James Wedner, Takao Fujisawa, Theresa W. Guilbert, Masanori Ikeda, Vinay Mehta, Jonathan S. Tam, Pradeep B. Lukka, Sara Asimus, Tomasz Durżyński, James Johnston, Wendy I. White, Mihir Shah, Viktoria Werkström, Maria L. Jison
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Comment on Nemet et al. Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-16 Chen Wang, Jian‐Te Lee
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Management of food protein‐induced allergic proctocolitis in Italy: A nationwide survey by SIGENP Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-16 Maurizio Mennini, Elena Lionetti, Monica Malamisura, Giovanni Di Nardo, Renata Auricchio, Paolo Lionetti, Claudio Romano
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Role of skin management in the prevention of atopic dermatitis and food allergy Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-14 Elizabeth Huiwen Tham, Kiwako Yamamoto‐Hanada, Agnes Sze Yin Leung, Yukihiro Ohya
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The effectiveness of an education program based on healthcare transition in adolescents with asthma: A randomized controlled trial Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-08 Fatma Dinç, Dilek Yıldız, Nazli Ercan
BackgroundAdolescents diagnosed with asthma make a transition to adult care when they reach a certain age. Besides, these adolescents need specialized education for them to become autonomous, competent, and adult patients and gain the necessary knowledge and skills related to their disease. In this study, by using a prospective randomized controlled trial design, we evaluated the effectiveness of an
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Pediatric hemophilia patient: Successful desensitization for drug‐induced fixed urticaria with prothrombin complex concentrate Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-07 Hatice Irmak Çelik, Eray Akay, Zeynep Şengül Emeksiz, Melek Işık, Hüsniye Neşe Yaralı, Emine Dibek Mısırlıoğlu
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Influence of the gut and airway microbiome on asthma development and disease Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-07 Tamar Smulders, Marc P. Van Der Schee, Anke H. Maitland‐Van Der Zee, Frederik G. Dikkers, Cornelis M. Van Drunen
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Dietary management of IgE and non‐IgE‐mediated food allergies in pediatric patients Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-07 Carina Venter, Franziska Roth‐Walter, Emilia Vassilopoulos, Allison Hicks
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Bacteria and viruses and their role in the preschool wheeze to asthma transition Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-06 Nikolaos G. Papadopoulos, Evaggelia Apostolidou, Michael Miligkos, Paraskevi Xepapadaki
Wheezing is the cardinal symptom of asthma; its presence early in life, mostly caused by viral infections, is a major risk factor for the establishment of persistent or recurrent disease. Early‐life wheezing and asthma exacerbations are triggered by common respiratory viruses, mainly rhinoviruses (RV), and to a lesser extent, respiratory syncytial virus, parainfluenza, human metapneumovirus, coronaviruses
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The importance of clinical history in the diagnosis of drug hypersensitivity in children Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-06 Giulia Liccioli, Leonardo Tomei, Benedetta Pessina, Jean‐Christoph Caubet, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Francesca Mori
BackgroundIn case of suspected hypersensitivity reactions (HRs) to drugs, a challenging area for pediatricians is detecting relevant elements in the parent‐reported history, in order to reach a definite diagnosis. We analyzed the concordance between the description of the HR and the medical reports documented at the time of the event. Furthermore, we studied any correlation between clinical history
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Fevers and ulcers in a newborn—Think genetics and act quickly Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-06 Maarja Soomann, Kimberly Gilmour, Tayfun Güngör, Jana Pachlopnik Schmid, Vasiliki Spyropoulou, Johannes Trück, Seraina Prader
The first child of a consanguineous family of Turkish descent developed recurrent fevers a few hours after birth and oral ulcers at the age of 10 days. The newborn was repeatedly evaluated for infectious causes of fever and received several courses of antibiotics as per guidelines for fever in newborns,1 but no causative organisms could be detected and there was no long-lasting effect of antimicrobial
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VIDEOASTHMA: Remote, real‐life evaluation of inhalation technique in asthmatic children Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-06 Célia Tillard, Camille Cisterne, Marie Moyart, Caroline Thumerelle, Elodie Drumez, Hélène Behal, Stéphanie Lejeune, Antoine Deschildre
Poor inhalation technique might contribute to asthma morbidity. In an hospital-based assessment study, a proper technique was observed in only 62% of 71 asthmatic children.1 Poor technique was also retained as one of the main causes of uncontrolled asthma in 7.8% of 142 patients referred to a pediatric asthma center.2 In a pilot study carried out in the United Kingdom, the authors reported a deterioration
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Direct oral challenge for immediate and non‐immediate beta‐lactam allergy in children: A real‐world multicenter study Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-01 Luis Moral, Teresa Toral, Candelaria Muñoz, Nuria Marco, Belén García‐Avilés, Laura Murcia, María José Forniés, María Cristina González, Francisco Canals, Esther Bragado, Javier Martínez Olmos, Carlos García‐Magán, José Domingo Moure González, Nuria Cortés, Magalí Giménez, Catalina Gómez, Ana Belén Rodríguez, Ana Moreno, José Manuel Lucas, Sergio Quevedo, Cristina Blasco, Yolanda Aliaga
BackgroundAllergy to beta‐lactam antibiotics (BLA) is frequently suspected in children, but a drug provocation test (DPT) rules it out in over 90% of cases. Direct oral DPT (DODPT), without skin or other previous tests, is increasingly been used to delabel non‐immediate BLA reactions. This real‐world study aimed to assess the safety and effectiveness of DODPT in children with immediate and non‐immediate
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Maternal dietary indexes are not linked to early childhood wheezing or atopic eczema Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-03-01 Elina Sivula, Heidi Puharinen, Sari Hantunen, Leea Keski‐Nisula, Katri Backman
BackgroundSeveral recent studies have investigated the association between maternal diet during pregnancy and wheezing or asthma in children. However, whether a specific dietary pattern during pregnancy protects children from wheezing or atopic diseases remains unclear. This study investigated the association between The Alternative Healthy Eating Index for Pregnancy (AHEI‐P), the Dietary Inflammatory
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Editorial comment on “Food‐induced anaphylaxis during infancy is associated with later sleeping and eating disorders” Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-26 Sophie Carra, Luciana Kase Tanno, Rachel Peters, Philippe Eigenmann
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Local anesthetics allergy in children: Evaluation of diagnostic tests with Real‐Life data Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-26 Nilay Caliskan, Guler Yildirim, Hamit Bologur, Hilal Gungor, Merve Karaca Sahin, Fatih Erbay, Sefika İlknur Kokcu Karadag, Deniz Ozceker
BackgroundLocal anesthetic (LA) drugs are commonly used in clinical practice to provide effective analgesia, including in dentistry and minor surgical procedures. The perception of a high risk of allergy in daily applications leads to the referral of atopic patients and those with other drug allergies to allergy clinics for the evaluation of allergic reactions to LA. The aim of this study was to determine
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Current insights into cow's milk allergy in children: Microbiome, metabolome, and immune response—A systematic review Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-16 Mariyana V. Savova, Pingping Zhu, Amy C. Harms, Renate G. van der Molen, Clara Belzer, Diana M. Hendrickx
The increasing prevalence of IgE-mediated cow's milk allergy (CMA) in childhood is a worldwide health concern. There is a growing awareness that the gut microbiome (GM) might play an important role in CMA development. Therefore, treatment with probiotics and prebiotics has gained popularity. This systematic review provides an overview of the alterations of the GM, metabolome, and immune response in
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Age-specific predictors of disease severity in children with respiratory syncytial virus infection beyond infancy and through the first 5 years of age Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-16 Helena Brenes-Chacon, Mariah Eisner, Santiago Acero-Bedoya, Octavio Ramilo, Asuncion Mejias
Respiratory syncytial virus (RSV) infection is associated with significant morbidity in infants. Risk factors for severe disease beyond the first 2 years of life have not been fully defined.
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Maternal mental health disorders and offspring asthma and allergic diseases: The role of child mental health Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-17 Bronwyn K. Brew, Tong Gong, Emma Ohlin, Anna M. Hedman, Henrik Larsson, Philip Curman, Cecilia Lundholm, Catarina Almqvist
Maternal psychological stress during pregnancy and postnatally has been shown to be associated with offspring atopic diseases (asthma, atopic dermatitis and allergic rhinitis). The aim of this study was to assess whether this association may be attributable to the child's own mental health disorders.
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Mite allergen sensitization patterns in Turkish children: Age‐related changes and molecular correlations Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-20 Sevda Tuten Dal, Umit Murat Sahiner, Ozge Soyer, Bulent Enis Sekerel
BackgroundMites are ubiquitous aeroallergens found worldwide. Elucidating individual mite allergen sensitization patterns provides critical insights for managing allergic diseases. This study aimed to investigate molecular allergen (MA) sensitization patterns across different age groups and explore cluster relationships among mite‐sensitized children.MethodsWe analyzed 76 children who exhibited sensitization
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A systematic review and meta-analysis on absolute eosinophil counts and the risk of asthma in preschool children with wheezing: An EAACI Task Force Report Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-10 Aleksander Adamiec, Maja Cieślik, Katarzyna Mączka, Joanna Tarnoruda, Signe Jensen, Bo Chawes, Klaus Bønnelykke, Jon R. Konradsen, Cilla Söderhäll, Heidi Makrinioti, Carlos A. Camargo, Kohei Hasegawa, Dominika Ambrożej, Tuomas Jartti, Marek Ruszczyński, Wojciech Feleszko
Preschool children with wheezing disorders pose diagnostic and therapeutic challenges and consume substantial healthcare resources. Peripheral eosinophil blood count (EBC) has been proposed as a potential indicator for future asthma development. This review by the European Academy of Allergy and Clinical Immunology (EAACI) Preschool Wheeze Task Force aimed to provide systematic evidence for the association
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Clinical, immunological, and genetic description of a Mexican cohort of patients with DOCK8 deficiency Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-14 Eduardo Liquidano-Perez, Gibert Maza-Ramos, Bethy Alexandra Perez Arias, Saul Oswaldo Lugo Reyes, Tania Barragan Arevalo, Sara Alejandra Solorzano-Morales, Edna Venegas Montoya, Aidé Tamara Staines-Boone, Rogelio Guzmán Cotaya, Satoshi Okada, Capucine Picard, Etienne Patin, Nideshda Ramirez-Uribe, Juan Carlos Bustamante-Ogando, Selma Cecilia Scheffler-Mendoza, Marco Antonio Yamazaki-Nakashimada, Marimar
We aimed to describe the clinical, immunological, and genetic features of patients with DOCK8 deficiency (DOCK8-Def) in a tertiary care center for children.
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Immune modulation by rural exposures and allergy protection Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-14 Yuhan Xing, Miranda Sin-Man Tsang, Zhaowei Yang, Maggie Haitian Wang, Vadim Pivniouk, Agnes Sze-Yin Leung, Ting-Fan Leung, Marjut Roponen, Bianca Schaub, Donata Vercelli, Chun-Kwok Wong, Jing Li, Gary Wing-Kin Wong
Growing up on traditional farms protects children from the development of asthma and allergies. However, we have identified distinct asthma-protective factors, such as poultry exposure. This study aims to examine the biological effect of rural exposure in China.
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The impact of perinatal and at birth risk factors on the progression from preschool wheezing to adolescent asthma Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-13 Claire Gallagher, Mehak Batra, Sowmya Nagappa Malamardi, Bircan Erbas
Asthma is a global health concern affecting millions of children and adolescents. This review focuses on the possible factors that are associated with the transition from preschool wheezing to childhood asthma and highlights the significance of early-life environmental exposures during pregnancy and the first 6 months of life in shaping allergies and asthma. We observed a scarcity of studies investigating
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Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-02-06 Sean Duke, James Maiarana, Pariya Yousefi, Elijah Burks, Samantha Gerrie, Audi Setiadi, , Kyla J. Hildebrand, Elliot James, Stuart E. Turvey, Janet G. Markle, Catherine M. Biggs
Cytotoxic T lymphocyte antigen-4 (CTLA-4), an inhibitory receptor expressed on T-cells, plays an essential role in regulating immune responses. In healthy individuals, CTLA-4 prevents overstimulation of T-cells and facilitates regulatory T-cell (Treg) suppressive function through competitive binding of CD80/CD86 on antigen-presenting cells.1 Heterozygous loss-of-function variants in CTLA4 cause the
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Life quality, depression, and anxiety levels in parents of children with primary immunodeficiency Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-01-11 Sibel Kaplan Sarıkavak, Talat Sarıkavak, Özge Türkyılmaz Uçar, Çiğdem Aydoğmuş, Mehmet Halil Celiksoy
Primary immune deficiencies (PID) encompasses genetic disorders that result in recurrent infections and immune dysregulation, often increasing the risk of malignancies. The aim of this study is to determine the quality of life, depression, and anxiety in parents of children with PID.
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Epigenomic and epigenetic investigations of food allergy Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-01-02 Yoojin Chun, Jo Hsuan Lee, Supinda Bunyavanich
As a potential link between genetic predisposition, environmental exposures, and food allergy outcomes, epigenetics has been a molecular variable of interest in ongoing efforts to understand food allergy mechanisms and outcomes. Here we review population-based investigations of epigenetic loci associated with food allergy, focusing on established clinical food allergy. We first provide an overview
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Genetics of preschool wheeze and its progression to childhood asthma Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2024-01-02 Alba A.B. Wolters, Elin T.G. Kersten, Gerard H. Koppelman
Wheezing is a common and heterogeneous condition in preschool children. In some countries, the prevalence can be as high as 30% and up to 50% of all children experience wheezing before the age of 6. Asthma often starts with preschool wheeze, but not all wheezing children will develop asthma at school age. At this moment, it is not possible to accurately predict which wheezing children will develop
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Understanding progression from pre-school wheezing to school-age asthma: Can modern data approaches help? Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-24 Darije Custovic, Sara Fontanella, Adnan Custovic
Preschool wheezing and childhood asthma create a heavy disease burden which is only exacerbated by the complexity of the conditions. Preschool wheezing exhibits both “curricular” and “aetiological” heterogeneity: that is, heterogeneity across patients both in the time-course of its development and in its underpinning pathological mechanisms. Since these are not fully understood, but clinical presentations
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Natural history of cow's milk allergy in children aged 6–12 years Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-24 Kei Kubota, Ken-ichi Nagakura, Yuki Ejiri, Sakura Sato, Motohiro Ebisawa, Noriyuki Yanagida
Approximately 50%–90% of children with immediate-type cow's milk allergy (CMA) acquire tolerance by pre-school age. We aimed to investigate the acquisition rate of CMA tolerance in children aged 6–12 years.
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Food-induced anaphylaxis during infancy is associated with later sleeping and eating disorders Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-21 Shay Nemet, Daniel Elbirt, Keren Mahlab-Guri, Shira Bezalel-Rosenberg, Ilan Asher, Aviv Talmon, Limor Rubin, Yaarit Ribak, Ruslan Sergienko, Yuval Tal, Oded Shamriz
Accumulating evidence suggests that food-induced anaphylaxis (FIA) may induce different psychological disorders (PDs). In this study, we aimed to further evaluate the effect of FIA, specifically when occurring in early life, on subsequent PDs development.
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Whole-exome sequencing to identify undiagnosed primary immunodeficiency disorders in children with community-acquired sepsis, admitted in the pediatric intensive care unit Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-21 Elham Rayzan, Mona Mirbeyk, Parmida Sadat Pezeshki, Masoud Mohammadpour, Bahareh Yaghmaie, Seyed Abbas Hassani, Meisam Sharifzadeh, Leila Tahernia, Nima Rezaei
Whole-exome sequencing (WES) provides a powerful diagnostic tool for identifying primary immunodeficiency diseases (PIDs). This study explores the utility of this approach in uncovering previously undiagnosed PIDs in children with community-acquired sepsis (CAS), with a medical history of recurrent infections or a family history of PIDs.
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Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC) Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-17 Krystallenia Paniskaki, Sarah Goretzki, Moritz Anft, Margarethe J. Konik, Toni L. Meister, Stephanie Pfaender, Klara Lechtenberg, Melanie Vogl, Burcin Dogan, Sebastian Dolff, Timm H. Westhoff, Hana Rohn, Ursula Felderhoff-Mueser, Ulrik Stervbo, Oliver Witzke, Christian Dohna-Schwake, Nina Babel
A proportion of the convalescent SARS-CoV-2 pediatric population presents nonspecific symptoms, mental health problems, and a reduction in quality of life similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID-19 symptomatic. However, data regarding its clinical manifestation and immune mechanisms are currently scarce.
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Editorial comment on: “Developing a prediction model of children's asthma risk using population-based family history health records” Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-17 Audrey Kamga, Enrica Manca, Davide Caimmi, Philippe Eigenmann, Ayobami Akenroye
CONFLICT OF INTEREST STATEMENT There is nothing to disclose in relation to this Editorial.
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Component-resolved diagnosis in childhood and prediction of asthma in early adolescence: A birth cohort study Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-10 Mariana Farraia, Francisca Castro Mendes, Oksana Sokhatska, Tiago Rama, Milton Severo, Adnan Custovic, João Cavaleiro Rufo, Henrique Barros, André Moreira
Component-resolved diagnosis (CRD) has been decisive in exploring the mechanisms of IgE sensitization, but the predictive ability to detect asthma has not been addressed. We aim to develop and evaluate the performance of a personalized predictive algorithm for asthma that integrates information on allergic sensitization using CRD.
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Severe bronchial hyperresponsiveness along with house dust mite allergy indicates persistence of asthma in young children Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-11 Helena Donath, Hans Klenner, Martin Hutter, Aniello Meoli, Jordis Trischler, Johannes Schulze, Katharina Blumchen, Stefan Zielen
Significant risk factors for persistence of asthma later in life are family history of allergies, early allergic sensitization and bronchial hyperresponsiveness (BHR). The evolution of BHR in young children without allergic sensitization and with house dust mite allergy (HDM) was investigated.
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Association between a maternal vegetarian diet during pregnancy and the occurrence of atopic dermatitis in children Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-12-06 Yi-Chun Su, Jia-Shan Xie, Rong-Hwa Jan, Chia-Jung Hsieh
Atopic dermatitis (AD) is rising globally, with genetics and environmental factors both playing crucial roles. Dietary habits during pregnancy are linked to children's allergic disease risk. However, limited studies have explored the association between maternal vegetarian diets during pregnancy and child AD. Therefore, this study aimed to examine the relationship between maternal vegetarian diets
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Editorial comments on “Sensitization trajectories to multiple allergen components in a population-based birth cohort” Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-22 Sabina Wärnberg Gerdin, Björn Nordlund, Philippe Eigenmann, Jon Genuneit
CONFLICT OF INTEREST STATEMENT No conflict of interest.
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From preschool wheezing to asthma: Environmental determinants Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-27 Yuhan Xing, Agnes Sze-Yin Leung, Gary Wing-Kin Wong
Wheezing is common among preschool children, representing a group of highly heterogeneous conditions with varying natural history. Several phenotypes of wheezing have been proposed to facilitate the identification of young children who are at risk of subsequent development of asthma. Epidemiological and immunological studies across different populations have revealed the key role of environmental factors
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Limited clinical role of blood eosinophil levels in early life atopic disease: A mother–child cohort study Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-27 Signe Kjeldgaard Jensen, Mathias Elsner Melgaard, Casper-Emil Tingskov Pedersen, Luo Yang, Nilo Vahman, Jacob P. Thyssen, Ann-Marie M. Schoos, Jakob Stokholm, Hans Bisgaard, Bo Chawes, Klaus Bønnelykke
Blood eosinophil count is a well-established biomarker of atopic diseases in older children and adults. However, its predictive role for atopic diseases in preschool children is not well established.
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Low agreement between Swedish national registers and parental questionnaires on allergic rhinitis Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-27 Styliana Vasileiadou, Göran Wennergren, Frida Strömberg Celind, Emma Goksör
Allergic rhinitis (AR) has been well documented using questionnaire-based studies. Here, we examine the agreement between parental-reported data during childhood with the emphasis on 12-year-olds and data from two national Swedish registers to determine whether register data on AR can supplement or replace questionnaire data.
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Trajectory of stratum corneum lipid subclasses in the first year of life and associations with atopic dermatitis: A prospective cohort study Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-13 Yi Zhang, Hongjian Gu, Ying Ye, Yun Li, Xiaohua Gao, Kaku Ken, Xiangyuan Huang, Wei Gao, Hongyan Chen, Jun Huang, Liuhui Wang, Weili Yan
Trajectories of stratum corneum (SC) lipid subclasses and their associations with infant atopic dermatitis (AD) are unclear. This study aimed to quantify the trajectories of 15 SC subclasses and carbon chain lengths and their associations with AD within 12 months.
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Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-07 Joanna Madej, Tania Atanassova, Sarah McGuire, Barry Cohen, Melissa Weidner, Yingting Zhang, Daniel B. Horton
Use of acid-suppressive medications (ASMs), for example, proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs), has been rising along with the incidence of pediatric immune-mediated diseases (IMDs). We conducted a scoping review to characterize the literature about prenatal or pediatric exposure to ASMs in relation to incident pediatric IMDs.
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Oral immunotherapy as a curative treatment for food-allergic preschool children: Current evidence and potential underlying mechanisms Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-03 Lieke J. C. Barten, Marit Zuurveld, Joyce Faber, Johan Garssen, Ted Klok
The worldwide rising prevalence of food allergy is a major public health concern. Standard care consists of allergen avoidance and rescue medication upon accidental exposure. Oral immunotherapy (OIT) is increasingly being studied as a treatment option. Although desensitization (an increased reaction threshold) is often achieved during OIT, sustained unresponsiveness (SU; clinical nonreactivity after
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Exhaled nitric oxide is only an asthma-relevant biomarker among children with allergic sensitization Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-03 Rikke Bjersand Sunde, Jonathan Thorsen, Frederikke Skov, Laura Hesselberg, Julie Kyvsgaard, Nilofar V. Følsgaard, Ann-Marie Malby Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes
Fraction of exhaled nitric oxide (FeNO) is used for diagnosing and monitoring asthma in children, but the influence of allergic sensitization is still poorly understood. Here, we investigate how asthma and allergic sensitization influence FeNO levels during childhood.
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Dominant-negative CARD11 loss-of-function variant presenting with hypereosinophilic syndrome. Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-01 Bridget E Wilson,Payge Van Stechelman,Rachel Mariani,Nikita Goswami,Nicole Sidebottom,Cindy S Bauer,Keith A Sacco
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Editorial Comment on "Atopic outcomes at 2 years in the CORAL cohort, born in COVID-19 lockdown". Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-11-01 Mónica Sandoval-Ruballos,Carmen Riggioni,Jon Genuneit
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From preschool wheezing to asthma: Immunological determinants Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-25 Kristina Laubhahn, Bianca Schaub
Asthma represents a chronic respiratory disease affecting millions of children worldwide. The transition from preschool wheezing to school-age asthma involves a multifaceted interplay of various factors, including immunological aspects in early childhood. These factors include complex cellular interactions among different immune cell subsets, induction of pro-inflammatory mediators and the molecular
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From preschool wheezing to asthma: Determinants Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-25 Ayobami Akenroye, Ömer Kalayci, Philippe Eigenmann
CONFLICT OF INTEREST STATEMENT The authors report no conflicts of interest.
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COVID-19 vaccine effectiveness in children by age groups. A population-based study in Galicia, Spain Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-24 Narmeen Mallah, Jacobo Pardo-Seco, Sonia Ares-Gómez, Luis-Ricardo López-Pérez, Juan-Manuel González-Pérez, Benigno Rosón, María-Teresa Otero-Barrós, Carmen Durán-Parrondo, Victoria Nartallo-Penas, Susana Mirás-Carballal, Carmen Rodríguez-Tenreiro-Sánchez, Irene Rivero-Calle, Alberto Gómez-Carballa, Antonio Salas, Federico Martinón-Torres
Studies on vaccine effectiveness (VE) against COVID-19 in the pediatric population are outgoing. We aimed to quantify VE against SARS-CoV-2 in two pediatric age groups, 5–11 and 12–17-year-old, while considering vaccine type, SARS-CoV-2 variant, and duration of protection.
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Management of children with allergies in preschool and school—Potential for improvements Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-24 Emmanouela Sdona, Annelie Turesson, Catherine Fahlén Zelander, Alexandra Lövquist, André Lauber, Antonios Georgelis, Anna Bergström, Marina Jonsson
Allergic diseases are common in children and may manifest for the first time at preschool or school.1 They may impair school performance, reduce quality of life, and cause severe reactions.2, 3 Parents have frequently concern over the safety of their child at school. Only few studies examine the management of children with allergies at school.1 In Sweden, a report by the National Board of Health and
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Editorial comment on “The alternative bile acid pathway can predict food allergy persistence in early childhood” Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-13 Marcelina J. Pyclik, Rodrigo Jiménez-Saiz, Agnes S. Y. Leung, Philippe Eigenmann
CONFLICT OF INTEREST STATEMENT All authors declare no competing interests in relation to this work.
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Can measles attenuate previous allergic sensitization in children? Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-10 Ngoc Tan Nguyen, Renske Schappin, Suzanne G. M. A. Pasmans, Marco W. J. Schreurs, Rik L. de Swart, Willem van de Veen
Measles is a highly contagious disease that is characterized by fever, cough, and a maculopapular skin rash. The causative agent, measles virus (MV), targets myeloid, lymphoid, and epithelial cells. Infection and depletion of memory B- and T lymphocytes expressing CD150 results in transient immune suppression, referred to as “immune amnesia”.1, 2 At the same time, MV infection also elicits a strong
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Corrigendum to “Frequency of fatal and recurrent anaphylaxis due to COW'S milk: A systematic review and meta-analysis of observational studies” Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-09
Pérez-Codesido S, Grifol-Clar E, Petrone MB, Malumbres MG, Garban PA, Tejedor-Alonso MA. Pediatr Allergy Immunol. 2023 Jul;34(7):e13977. In Paragraph 1 of the “Results-3.2 Frequency of recurrent anaphylaxis due to cow's milk” section, studies from Orhan et al. and Barzegar et al. have been removed from our review on recurrent anaphylaxis due to cow's milk. The new pooled prevalence of recurrence (PR)
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Asthma medication and risk of dental diseases in children – A prospective cohort study Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-09 Pia Elisabeth Nørrisgaard, Dorte Haubek, Ann-Marie Malby Schoos, Jan Kühnisch, Bo L. Chawes, Jakob Stokholm, Hans Bisgaard, Klaus Bønnelykke
Dental caries and enamel defects are the main causes of poor dental health in children, with a substantial impact on their well-being. Use of inhaled asthma medication is a suspected risk factor, but there is a lack of prospective studies investigating this and other prenatal and early life risk factors.
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Developing a prediction model of children asthma risk using population-based family history health records Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-04 Amani F. Hamad, Lin Yan, Mohammad Jafari Jozani, Pingzhao Hu, Joseph A. Delaney, Lisa M. Lix
Identifying children at high risk of developing asthma can facilitate prevention and early management strategies. We developed a prediction model of children's asthma risk using objectively collected population-based children and parental histories of comorbidities.
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γδ CD8+ T cells and novel genetic variants in ZAP70 deficiency. Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-01 Isma Shah,Samuel Chiang,Li Yang,Nagako Akeno,Allison Kelly,Jason White,Emi Caywood,Sharon Hwang,Trong Le
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Long-term prognosis after low-dose peanut challenge for patients with a history of anaphylaxis. Pediatric Allergy Immunol. (IF 4.4) Pub Date : 2023-10-01 Nobuko Akamatsu,Ken-Ichi Nagakura,Sakura Sato,Noriyuki Yanagida,Motohiro Ebisawa