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Surgical outcomes and follow-up results of 53 pediatric craniopharyngioma cases: a single-center study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-29 Melih Caklili, Ayse Uzuner, Eren Yilmaz, Seda Duman Ozturk, Filiz Mine Cizmecioglu Jones, Sibel Balci, Dilek Icli, Anil Ergen, Burak Cabuk, Ihsan Anik, Savas Ceylan
OBJECTIVE Craniopharyngiomas are locally invasive neoplasms, and they cause potential lifelong morbidity because of their tendency for local recurrence. Despite advancements in endoscopic techniques, gross-total resection (GTR) of tumors with invasion or adhesion to important surrounding anatomical structures is extremely difficult. The authors present a single-center study that evaluated the impact
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Does recovery after sport-related concussion vary by time point in a season? A multi-sport investigation J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-29 Anthony E. Bishay, Kristen L. Williams, Jacob Jo, Samuel Fitch, Douglas P. Terry, Scott L. Zuckerman
OBJECTIVE Seasonality, or the specific point in time within a season in which the injury occurs, may have an impact on the recovery following sport-related concussions (SRCs). In a cohort of high school athletes across multiple sports, the authors sought to investigate the impact of seasonality on 1) concussion frequency, 2) acute symptom presentation (initial Post-Concussion Symptom Scale [PCSS] score)
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Rupture risk and outcomes of giant aneurysms in pediatric patients: a multi-institutional case series and systematic review J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-29 Saksham Gupta, Blake M. Hauser, Joshua S. Catapano, Dara Farhadi, Patrick R. Ng, Joshua D. Bernstock, Alfred Pokmeng See, Michael T. Lawton, Edward R. Smith, Rose Du
OBJECTIVE Giant aneurysms in pediatric patients are vascular lesions that can cause significant neurological morbidity and mortality. Their rarity has precluded large cohort studies to inform their management. The objective of this study was to understand the clinical course and outcomes of giant aneurysms in pediatric patients.METHODS The authors performed a multi-institutional cohort study of cases
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Intraventricular hemorrhage volume and younger age at surgery may be risk factors for postoperative hydrocephalus after hemispherotomy in children J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-29 Munetake Yoshitomi, Keiya Iijima, Kenzo Kosugi, Yutaro Takayama, Yuiko Kimura, Yuu Kaneko, Takahiro Kawashima, Hisateru Tachimori, Noriko Sumitomo, Shimpei Baba, Takashi Saito, Eiji Nakagawa, Motohiro Morioka, Masaki Iwasaki
OBJECTIVE Hemispherotomy is an effective treatment for intractable hemispheric epilepsy; however, hydrocephalus remains a common complication of the procedure. The causes of hydrocephalus following hemispherotomy have not been fully elucidated; therefore, the purpose of this study was to identify the risk factors associated with the condition.METHODS The authors investigated the records of all patients
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MRI characteristics of H3 G34–mutant diffuse hemispheric gliomas and possible differentiation from IDH–wild-type glioblastomas in adolescents and young adults J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-29 Hanbing Shao, Jing Gong, Xiaorui Su, Ni Chen, Shuang Li, Xibiao Yang, Simin Zhang, Zhangfeng Huang, Wei Hu, Qiyong Gong, Yaou Liu, Qiang Yue
OBJECTIVE H3 G34–mutant diffuse hemispheric gliomas (G34m-DHGs) are rare and constitute a new infiltrating brain tumor entity whose characteristics require elucidation, and their difference from isocitrate dehydrogenase–wild-type glioblastomas (IDH-WT-GBMs) needs to be clarified. In this study, the authors report the demographic, clinical, and neuroradiological features of G34m-DHG and investigate
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Review of the targeting accuracy of frameless and frame-based robot-assisted deep brain stimulation electrode implantation in pediatric patients using the Neurolocate module J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-22 Raenette David, Maria Rosaria Scala, Jonathan Ellenbogen
OBJECTIVE The Neurolocate module is a 3D frameless patient registration module that is designed for use with the Neuromate stereotactic robot. Long-term electrical stimulation of the globus pallidus internus (GPi) and subthalamic nucleus (STN) via deep brain electrode implantation is particularly successful in a select group of movement disorders in pediatric patients. This study aimed to review the
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Management of cerebrospinal fluid pseudocysts in the laparoscopic age J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-15 Brett A. Whittemore, Bruno P. Braga, Angela V. Price, Rafael De Oliveira Sillero, Frederick H. Sklar, Stephen M. Megison, Bradley E. Weprin, Dale M. Swift
OBJECTIVE Abdominal CSF pseudocysts are an uncommon but challenging complication of ventriculoperitoneal shunts. Pseudocysts consist of a loculated intraperitoneal compartment that inadequately absorbs CSF and may be infected or sterile at diagnosis. The treatment goal is to clear infection if present, reduce inflammation, and reestablish long-term function in an absorptive (intraperitoneal) space
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Predictive factors of hydrocephalus development in pediatric patients undergoing hemispherectomy for intractable epilepsy J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-15 Akshay Sharma, Michael Mann, Alan Gordillo, Ansh Desai, Robert Winkleman, Demitre Serletis, Ahsan N. Moosa, Richard Rammo, William Bingaman
OBJECTIVE Hemispherectomy surgery is an effective procedure for pediatric patients with intractable hemispheric epilepsy. Hydrocephalus is a well-documented complication of hemispherectomy contributing substantially to patient morbidity. Despite some clinical and operative factors demonstrating an association with hydrocephalus development, the true mechanism of disease is incompletely understood.
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Pediatric neuroblastoma with intraspinal extension: the role of surgical management J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-15 Diana Chang, Taemin Oh, Jarod L. Roland, Katherine K. Matthay, Kieuhoa T. Vo, Caleb S. Edwards, Peter P. Sun, Kurtis I. Auguste, Nalin Gupta
OBJECTIVE Neuroblastoma with spinal involvement accounts for up to 30% of pediatric spinal tumors and can cause profound neurological deficits. Chemotherapy is the preferred treatment option, but in select patients resection may be indicated. The goal of this study was to identify preoperative factors that led to early surgical intervention, with a specific emphasis on identifying differences on long-term
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Nomogram for preoperative estimation of symptomatic subdural hygroma risk in pediatric intracranial arachnoid cysts J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-08 Heng Zhao, Yufan Chen, Shuaiwei Tian, Baocheng Wang, Yang Zhao, Jie Ma
OBJECTIVE The occurrence and predictors of symptomatic subdural hygroma (SSH) subsequent to the fenestration of pediatric intracranial arachnoid cysts (IACs) are unclear. In this study, the authors aimed to investigate the likelihood of an SSH following IAC fenestration and the impact on operative efficacy with the ultimate goal of constructing a nomogram. METHODS The medical records of 1782 consecutive
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Association between hospital volume and in-hospital mortality in pediatric severe traumatic brain injury: a nationwide retrospective observational study in Japan J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-08 Shu Utsumi, Shingo Ohki, Takeshi Ueda, Shunsuke Amagasa, Mitsuaki Nishikimi, Nobuaki Shime
OBJECTIVE The objective of this study was to investigate the association between hospital volume and in-hospital mortality in pediatric patients with severe traumatic brain injury (TBI).METHODS This retrospective cohort study used data from the Japan Trauma Data Bank between 2010 and 2018, specifically those of pediatric patients with severe TBI (Glasgow Coma Scale [GCS] score < 9 and head Abbreviated
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Safety and efficacy of intrathecal baclofen trials for the treatment of hypertonia: a retrospective cohort study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-08 Sunny Abdelmageed, Victoria Jane Horak, James Mossner, Ryan Wang, Timothy Krater, Jeffrey S. Raskin
OBJECTIVE Intrathecal baclofen (ITB) is an effective treatment for refractory hypertonia in children. ITB has long been effective for the treatment of spasticity, and indications have naturally evolved to include dystonia and mixed pediatric movement disorders (PMDs). The established uses for ITB trials are insurance prerequisite, mixed tone, and family request. Despite agreement for ITB therapy by
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Management and outcomes of pediatric traumatic brain injury in Africa: a systematic review J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-01 Nithin Gupta, Varun Kasula, Romaric Waguia Kouam, Andreas Seas, Ignatius Esene, Adefolarin O. Malomo, Matthew T. Shokunbi, Michael M. Haglund, Anthony T. Fuller, Alvan-Emeka K. Ukachukwu
OBJECTIVE Traumatic brain injury (TBI) carries a major global burden of disease; however, it is well established that patients in low- and middle-income countries, such as those in Africa, have higher mortality rates. Pediatric TBI, specifically, is a documented cause for concern as injuries to the developing brain have been shown to lead to cognitive, psychosocial, and motor problems in adulthood
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Subdural hematoma, retinal hemorrhage, and fracture triad as a clinical predictor for the diagnosis of child abuse J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-01 James C. Mamaril-Davis, Katherine Riordan, Hasan Sumdani, Paul Bowlby, Maryam Emami Neyestanak, Lauren Simpson, Anthony M. Avellino, Andrew Tang, Martin E. Weinand
OBJECTIVE Nonaccidental trauma (NAT) is a major cause of traumatic death during infancy and early childhood. Several findings are known to raise the index of clinical suspicion: subdural hematoma (SDH), retinal hemorrhage (RH), fracture, and external trauma. Combinations of certain injury types, determined via statistical frequency associations, may assist clinical diagnostic tools when child abuse
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Pediatric shunt failure: finding predictability in the sea of uncertainty J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-12-01 Mohammed Nadeem, Vishal Jirankali, Souvik Singha, Gaurav Tyagi, Alok Mohan Uppar, Manish Beniwal, Subhas Kanti Konar, Gyani Jail Singh Birua, Lingaraju Thyagatura, Dhaval Shukla, Dwarakanath Srinivas
OBJECTIVE Shunt malfunction is a complication that can have devastating implications. In this study, the authors aimed to evaluate the rate of shunt revision in a single institution over 5 years and to determine the factors associated with shunt revision in the pediatric population.METHODS This retrospective report assimilated data from all patients ≤ 18 years old who underwent shunt surgery between
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Shunt infection prevention practices in Hydrocephalus Clinical Research Network–Quality: a new quality improvement network for hydrocephalus management J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-24 Mandeep S. Tamber, Hailey Jensen, Jason Clawson, Nichol Nunn, John C. Wellons, Jodi Smith, Jonathan E. Martin, John R. W. Kestle
OBJECTIVE Knowledge-based tools used to standardize perioperative care, such as the shunt infection prevention protocol of the Hydrocephalus Clinical Research Network (HCRN), have demonstrated their ability to reduce surgeon-based and center-based variations in outcomes and improve patient care. The mere presence of high-quality evidence, however, does not necessarily translate into improved patient
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Application of the Rotterdam postoperative cerebellar mutism syndrome prediction model in patients undergoing surgery for medulloblastoma in a single institution J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-24 Savannah Bush, Paul Klimo, Arzu Onar-Thomas, Jie Huang, Frederick A. Boop, Amar Gajjar, Giles W. Robinson, Raja B. Khan
OBJECTIVE Postoperative cerebellar mutism syndrome (CMS) develops in up to 40% of children with medulloblastoma. The Rotterdam model (RM) has been reported to predict a 66% risk of CMS in patients with a score of ≥ 100. The aim of this study was to retrospectively apply the RM to an independent cohort of patients with newly diagnosed medulloblastoma and study the applicability of the RM in predicting
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Thirty-day surgical morbidity and risk factors in pediatric brain tumor surgery: a 10-year nationwide retrospective study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-17 Kasper Amund Henriksen, Ninna Brix, Ruta Jakubauskaite, Gorm Von Oettingen, Mathias Rathe, Jane Skjøth-Rasmussen, Jon Foss-Skiftesvik, René Mathiasen
OBJECTIVE Pediatric neuro-oncological surgery is often associated with significant risk; however, comprehensive data on surgical morbidity remain limited. The purpose of this study was therefore to provide national population-based data on both the incidence and characteristics of poor postoperative outcomes following pediatric intracranial neuro-oncological surgery. Additionally, the authors aimed
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Acute psychological symptom profiles in high school football players following sport-related concussion J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-17 Maryam Y. Jawid, Kristen L. Williams, Jacob Jo, Tyler M. Hill, Olivia L. Prosak, Amad Amedy, Trevor J. Anesi, Douglas P. Terry, Scott L. Zuckerman
OBJECTIVE In a cohort of high school football athletes, the authors sought to 1) describe the proportion of those with acute psychological symptoms postconcussion, 2) determine predictors of more acute psychological symptoms postconcussion, and 3) determine if acute psychological symptoms impact recovery.METHODS A retrospective cohort study of high school football athletes (14–18 years of age) who
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Long-term outcomes of deep pediatric arteriovenous malformations J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-10 Prateek Agarwal, Nikhil Sharma, Gautam Nayar, Rachel C. Jacobs, Alhamza Al-Bayati, L. Dade Lunsford, Michael M. McDowell, Stephanie Greene
OBJECTIVE Multimodality treatment has been shown to be the optimal management strategy for pediatric arteriovenous malformations (AVMs). Deep AVMs represent a subset of AVMs for which optimal management may be achieved with a combination of radiosurgery and highly selective embolization, in the absence of compelling features requiring operative intervention. The objective of this study was to identify
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Do academic accommodations help students recover following sport-related concussion? A retrospective study of 96 youth athletes J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-10 Grant H. Rigney, Jacob Jo, Carter Burns, Kristen L. Williams, Douglas P. Terry, Scott L. Zuckerman
OBJECTIVE Many schools utilize academic accommodations to help athletes return-to-learn after sport-related concussion, yet little is known about the impact of accommodations on recovery. In a cohort of adolescent athletes with sport-related concussion, the authors sought to 1) describe academic accommodations, 2) determine predictors of receiving accommodations, and 3) determine how accommodations
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Systematic review of transcranial and endoscopic endonasal approaches for craniopharyngiomas in children: is there an evolution? J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-10 Elena d’Avella, Francesca Vitulli, Jacopo Berardinelli, Giuseppe Cinalli, Domenico Solari, Paolo Cappabianca, Luigi Maria Cavallo
OBJECTIVE The optimal surgical approach for pediatric craniopharyngiomas (CPs) remains a matter of debate, with selection bias classically precluding a fair comparison of outcomes between the transcranial approach (TCA) and endoscopic endonasal approach (EEA). The purpose of this systematic review was to analyze the current role of EEA in the treatment of pediatric CPs and to determine whether, upon
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An online calculator using machine learning for predicting survival in pediatric patients with medulloblastoma J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-03 Cathleen C. Kuo, Andre Monteiro, Jaims Lim, Nolan J. Brown, Matthew J. Recker, Moleca M. Ghannam, Julian L. Gendreau, Veetai Li, Renée M. Reynolds
OBJECTIVE Medulloblastoma is the most common malignant intracranial tumor affecting the pediatric population. Despite advancements in multimodal treatment over the past 2 decades yielding a 5-year survival rate > 75%, children who survive often have substantial neurological and cognitive sequelae. The authors aimed to identify risk factors and develop a clinically friendly online calculator for prognostic
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Approach, complications, and outcomes for 37 consecutive pediatric patients undergoing laser ablation for medically refractory epilepsy at Stanford Children’s Health J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-03 Maria Isabel Barros Guinle, Thomas Johnstone, Daphne Li, Harsheen Kaur, Brenda E. Porter, Gerald A. Grant
OBJECTIVE The objective of this study was to better understand the safety and efficacy of laser interstitial thermal therapy (LITT) for children with medically refractory epilepsy.METHODS Thirty-seven consecutive pediatric epilepsy patients at a single pediatric center who underwent LITT ablation of epileptogenic foci between May 2017 and December 2021 were retrospectively reviewed. Patient demographics
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Laser interstitial thermal therapy compared with open resection for treating subependymal giant cell astrocytoma J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-11-03 Diane J. Aum, Rebecca A. Reynolds, Sean D. McEvoy, Michael Wong, Jarod L. Roland, Matthew D. Smyth
OBJECTIVE Subependymal giant cell astrocytomas (SEGAs) are WHO grade 1 tumors associated with tuberous sclerosis that classically arise from the ventricular wall near the caudate groove and foramen of Monro. Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique, which works by heating a stereotactically placed laser fiber to ablative temperatures under MRI thermometry
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Concurrent impact of de novo mutations on cranial and cortical development in nonsyndromic craniosynostosis J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-10-27 Emre Kiziltug, Phan Q. Duy, Garrett Allington, Andrew T. Timberlake, Riki Kawaguchi, Aaron S. Long, Mariana N. Almeida, Michael L. DiLuna, Seth L. Alper, Michael Alperovich, Daniel H. Geschwind, Kristopher T. Kahle
OBJECTIVE Nonsyndromic craniosynostosis (nsCS), characterized by premature cranial suture fusion, is considered a primary skull disorder in which impact on neurodevelopment, if present, results from the mechanical hindrance of brain growth. Despite surgical repair of the cranial defect, neurocognitive deficits persist in nearly half of affected children. Therefore, the authors performed a functional
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Cervical saccular limited dorsal myeloschisis, so-called "cervical myelomeningocele": long-term follow-up of a single-center series and systematic review J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-10-20 Seyed Farzad Maroufi, Mohammad Amin Dabbagh Ohadi, Iman Hosseinnejad, Keyvan Tayebi Meybodi, Alireza Takzare, Bahar Ashjaei, Farideh Nejat, Zohreh Habibi
OBJECTIVE Cervical saccular limited dorsal myeloschisis (LDM), previously so-called "cervical myelomeningocele," is a rare spinal dysraphism. Although the pathogenesis of true myelomeningocele is primary neurulation failure, LDM results from a delayed abnormality during the final stages of neurulation. The aim of the study was to evaluate the outcome of these patients and to assess the correlation
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Association of cerebrospinal fluid parameters with treatment and complications among children with cerebrospinal fluid shunt infections: a multicenter study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-10-13 Michael T. Hawkes, Alastair McAlpine, Michelle Barton, Adrianna Ranger, Archana Balamohan, H. Dele Davies, Gwenn Skar, Marie-Astrid Lefebvre, Ahmed Almadani, Dolores Freire, Nicole Le Saux, Jennifer Bowes, Jocelyn A. Srigley, Patrick Passarelli, John Bradley, Sarah Khan, Rupeena Purewal, Isabelle Viel-Thériault, Joan L. Robinson
OBJECTIVE Cerebrospinal fluid (CSF) white blood cell (WBC) count, neutrophil percentage, protein concentration, and glucose level are typically measured at diagnosis and serially during the treatment of CSF shunt infections. The objective of this retrospective cohort study was to describe the longitudinal profile of CSF parameters in children with CSF shunt infections and assess their association with
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Effect of thin-split encephalomyosynangiosis on transient neurological events in revascularization surgery for pediatric patients with moyamoya disease J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-10-13 Kazuki Ishii, Fumiaki Kanamori, Yoshio Araki, Kenji Uda, Kinya Yokoyama, Takashi Mamiya, Kai Takayanagi, Shunsaku Goto, Masahiro Nishihori, Takashi Izumi, Ryuta Saito
OBJECTIVE Transient neurological events (TNEs) are among the most important events after revascularization surgery in pediatric patients with moyamoya disease (MMD). Although hemodynamic changes and crying are representative factors of TNEs, brain compression by encephalomyosynangiosis (EMS) is another important cause of TNEs. Therefore, the authors assumed that making the EMS as thin as possible reduces
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Clinical outcomes of MR-guided laser interstitial thermal therapy corpus callosum ablation in drug-resistant epilepsy: a systematic review and meta-analysis J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-10-13 Jasmine L. Hect, Emily Harford, Seyed Farzad Maroufi, Mary Lou Klem, Alireza Mansouri, Taylor J. Abel
OBJECTIVE The goal of this systematic review and meta-analysis was to provide an updated analysis of studies investigating outcomes, morbidity, and mortality associated with MR-guided laser interstitial thermal therapy (MRgLITT) corpus callosum ablation (CCA).METHODS Study inclusion criteria for screening required that studies report on human subjects only, including patients aged 1–52 years diagnosed
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Machine learning models for predicting seizure outcome after MR-guided laser interstitial thermal therapy in children J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-10-06 Omar Yossofzai, Scellig S. D. Stone, Joseph R. Madsen, Shelly Wang, John Ragheb, Ismail Mohamed, Robert J. Bollo, Dave Clarke, M. Scott Perry, Alexander G. Weil, Jeffrey S. Raskin, Jonathan Pindrik, Raheel Ahmed, Sandi K. Lam, Aria Fallah, Cassia Maniquis, Andrea Andrade, George M. Ibrahim, James Drake, James T. Rutka, Jignesh Tailor, Nicholas Mitsakakis, Elysa Widjaja
OBJECTIVE MR-guided laser interstitial thermal therapy (MRgLITT) is associated with lower seizure-free outcome but better safety profile compared to open surgery. However, the predictors of seizure freedom following MRgLITT remain uncertain. This study aimed to use machine learning to predict seizure-free outcome following MRgLITT and to identify important predictors of seizure freedom in children
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Risk factors associated with in-hospital adverse events: a multicenter observational cohort study of 1853 pediatric patients with traumatic spinal cord injury J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-29 Armaan K. Malhotra, Christopher S. Lozano, Husain Shakil, Christopher W. Smith, George M. Ibrahim, David E. Lebel, Abhaya V. Kulkarni, Jefferson R. Wilson, Christopher D. Witiw, Avery B. Nathens
OBJECTIVE In this study, the authors aimed to quantify the frequency of in-hospital major adverse events (AEs) in a multicenter cohort of pediatric patients with spinal cord injury (SCI) managed at North American trauma centers. They also sought to identify patient and injury factors associated with the occurrence of major and immobility-related AEs.METHODS Data derived from the American College of
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Predicting endoscopic third ventriculostomy success in pediatric shunt dysfunction: a monocentric retrospective case series of 70 consecutive children, systematic review, and meta-analysis J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-29 Lelio Guida, Flavie Grenier-Chartrand, Sandro Benichi, Syril James, Giovanna Paternoster, Marie Bourgeois, Volodia Dangouloff-Ros, Antonio Messina, Nathalie Boddaert, Stéphanie Puget, Kevin Beccaria, Thomas Blauwblomme
OBJECTIVE The outcome of endoscopic third ventriculostomy (ETV) in children who had previously received shunts and who were experiencing shunt dysfunction is still discussed in terms of efficacy (success rate from 40% to 80%) and safety (0%–32.5% of complications). Reported predictive factors of secondary ETV failure are age, early onset of hydrocephalus, and prematurity. The best surgical strategy
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Regression of periventricular anastomosis after indirect revascularization in pediatric patients with moyamoya disease J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-22 Elizabeth Yi Zheng, Shoko Hara, Motoki Inaji, Yoji Tanaka, Tadashi Nariai, Taketoshi Maehara
OBJECTIVE The aim of this study was to evaluate whether indirect revascularization in pediatric patients with moyamoya disease leads to periventricular anastomosis (PVA) regression, which is markedly developed in moyamoya vessels and is regarded as a risk factor for hemorrhage.METHODS Pediatric patients with moyamoya disease treated with indirect revascularization from 2011 to 2021 were included in
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The role of traditional social determinants of health in referral patterns, timing of surgery, and Chiari Health Index for Pediatrics–determined quality of life in children with symptomatic Chiari type I malformation J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-15 Katherine A. Kelly, Bradley S. Guidry, Gunther W. Wong, Harrison C. Thomas, Mariam Girgis, Chevis N. Shannon, John C. Wellons, Michael J. Cools
OBJECTIVE Understanding the impact of the social determinants of health on the utilization of healthcare resources is an important step in eliminating inequalities. The goal of this study was to determine the role of social determinants of health in referral patterns, timing of consultation/intervention, and quality of life in children with Chiari malformation type I (CM-I). METHODS A retrospective
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Achondroplasia Natural History Study (CLARITY): 60-year experience with hydrocephalus in achondroplasia from four skeletal dysplasia centers J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-15 Jeffrey Campbell, Janet M. Legare, Joseph Piatt, Ethan Gough, Richard M. Pauli, S. Shahrukh Hashmi, David F. Rodriguez-Buritica, Peggy Modaff, Mary Ellen Little, Maria Elena Serna, Cory J. Smid, Lorena Dujmusic, Jacqueline T. Hecht, Julie E. Hoover-Fong, Michael B. Bober
OBJECTIVE The objective of this study was to describe the incidence and management of hydrocephalus in patients with achondroplasia over a 60-year period at four skeletal dysplasia centers.METHODS The Achondroplasia Natural History Study (CLARITY) is a registry for clinical data from achondroplasia patients receiving treatment at four skeletal dysplasia centers in the US from 1957 to 2017. Data were
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Survival and neurological outcomes after stereotactic biopsy of diffuse intrinsic pontine glioma: a systematic review J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-08 Mahalia Dalmage, Melissa A. LoPresti, Prottusha Sarkar, Sruthi Ranganathan, Sunny Abdelmageed, Manasa Pagadala, Nathan A. Shlobin, Sandi Lam, Michael DeCuypere
OBJECTIVE Diffuse intrinsic pontine gliomas (DIPGs) are aggressive and malignant tumors of the brainstem. Stereotactic biopsy can obtain molecular and genetic information for diagnostic and potentially therapeutic purposes. However, there is no consensus on the safety of biopsy or effect on survival. The authors aimed to characterize neurological risk associated with and the effect of stereotactic
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Does earlier vestibular therapy after sport-related concussion lead to faster recovery? J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-08 Michael Zargari, Kristen Williams, Jacob Jo, Trevor J. Anesi, Olivia L. Prosak, Amad Amedy, Anthony E. Bishay, Scott L. Zuckerman, Douglas P. Terry
OBJECTIVE Many patients experience vestibular dysfunction following a sport-related concussion (SRC). Vestibular rehabilitation therapy has recently become more well established. In a cohort of athletes with SRC, the authors sought to 1) assess the relationship between symptoms at the initial clinic visit and time to referral for vestibular therapy, and 2) evaluate whether earlier referral to vestibular
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Surgical indication of pediatric Rathke’s cleft cyst based on a 20-year retrospective cohort J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-01 Jong Seok Lee, Yong Hwy Kim, Eun Jung Koh, Ji Hoon Phi, Ji Yeoun Lee, Kyung Hyun Kim, Kyu-Chang Wang, Jung-Eun Cheon, Sung-Hye Park, Young Ah Lee, Choong Ho Shin, Seung-Ki Kim
OBJECTIVE Rathke’s cleft cyst (RCC) is the most commonly encountered pituitary incidentaloma in children. Because RCC is not frequently diagnosed in children, there are few reports on pediatric RCCs. The natural course of the disease and appropriate treatments are still obscure. The present study aimed to elucidate the natural history and surgical indications of RCCs in children.METHODS The authors
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Middle meningeal artery embolization in the management of chronic subdural hematoma in medically complex pediatric neurosurgical patients: technical note J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-01 Anne M. Coyle, Erin K. M. Graves, Shih-Shan Lang, Benjamin C. Kennedy, Tracy M. Flanders, Alexander M. Tucker, Phillip B. Storm, Anne Marie Cahill, Bryan A. Pukenas, Peter J. Madsen
Middle meningeal artery (MMA) embolization has gained acceptance as a treatment for chronic subdural hematoma (cSDH) in adult patients but has not been well described in pediatric patients. Standard cSDH treatment has historically consisted of burr hole drainage with or without subdural drain placement. However, due to the high rate of recurrence and frequency of comorbidities within this population
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The role of surgery in recurrent ependymomas J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-01 Guillermo Aldave, M. Fatih Okcu, Lucia Ruggieri, Arnold C. Paulino, Susan McGovern, William Whitehead, Howard L. Weiner, Murali Chintagumpala
OBJECTIVE The role of surgery in recurrent ependymomas and its contribution to the outcome are not well defined. While gross-total resection (GTR) has shown benefit in newly diagnosed patients with improvement in progression-free survival (PFS), its impact after recurrence is not known. Its role in distant relapses or multiple local recurrences is similarly less well understood. The objective of this
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Palliation for catastrophic nonlocalizing epilepsy: a retrospective case series of complete corpus callosotomy at a single institution J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-09-01 James E. Baumgartner, Fatima Q. Ajmal, Michael E. Baumgartner, Joo Hee Seo, Ammar Hussain, Michael Westerveld, Holly J. Skinner, Angel O. Claudio, Elakkat Gireesh, Amy Cummiskey, Lacie Manthripragada, Ki Hyeong Lee
OBJECTIVE In this study, the authors describe their 10-year single-institution experience with single-step complete corpus callosotomy (CCC) for seizure management in pediatric and adult patients with catastrophic, medically refractory, nonlocalizing epilepsy at Advent Health Orlando. METHODS The authors conducted a retrospective observational study of patients aged 6 months to 49 years who underwent
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The evolution of stereoelectroencephalography: symbiotic progress in medical imaging and procedural technologies J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-25 Aaron Parrott, Sherwin A. Tavakol, Kristin Zieles, Andrew Jea, Virendra R. Desai
Stereoelectroencephalography (sEEG) was pioneered in France, at a time when cerebral anatomy was invisible to contemporaneous imaging modalities. Epilepsy surgeons relied on indirect targeting techniques to identify epileptogenic tissue. Since then, alongside the rapid rise of medical imaging technology, sEEG has experienced dramatic stepwise progress. A flurry of advancements has pushed this technique
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Neurosurgical management of cervicomedullary compression, spinal stenosis, and hydrocephalus in pediatric achondroplasia: a systematic review J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-18 Oluwatoyin Akinnusotu, Albert M. Isaacs, Michelle Stone, Christopher M. Bonfield
OBJECTIVE Pediatric achondroplasia is often associated with conditions requiring neurosurgical intervention, including CSF diversion and multilevel spinal decompression. However, there is a lack of clinical guidelines and reliable estimates of the benefits and risks of these interventions. This study aimed to summarize the literature on the neurosurgical management of pediatric achondroplasia patients
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The prevalence and risk factors of coagulopathy in pediatric patients undergoing surgery for epilepsy J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-18 Renqing Zhu, Qing Wang, Yuanfeng Zhou, Wei Shi, Yi Zhang, Min Wang, Hao Li, Rui Zhao
OBJECTIVE Hematological consequences of novel antiseizure medications (ASMs) or combined therapies are rarely reported, especially in pediatric patients undergoing surgery for epilepsy. This study aimed to assess the prevalence and risk factors of coagulation dysfunction in this population and evaluate their relationship with intra- and postoperative bleeding.METHODS Three hundred ninety children who
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Perioperative complications and secondary retethering after pediatric tethered cord release surgery J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-11 James Pan, Scott H. Boop, Jason K. Barber, Srinivas M. Susarla, Sharon Durfy, Jeffrey G. Ojemann, Hannah E. Goldstein, Amy Lee, Samuel Browd, Richard G. Ellenbogen, Jason S. Hauptman
OBJECTIVE Tethered cord syndrome refers to a constellation of symptoms characterized by neurological, musculoskeletal, and urinary symptoms, caused by traction on the spinal cord, which can be secondary to various etiologies. Surgical management of simple tethered cord etiologies (e.g., fatty filum) typically consists of a single-level lumbar laminectomy, intradural exploration, and coagulation and
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Epileptic versus neuro-oncological focus of management in pediatric patients with concurrent primary brain lesion and seizures: a systematic review J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-11 Maxwell D. Gruber, Jonathan Pindrik, Mark Damante, Lauren Schulz, Ammar Shaikhouni, Jeffrey R. Leonard
OBJECTIVE Seizures can be a debilitating manifestation of underlying neoplastic intracranial pathology. Existing literature offers a paucity of scientific consensus regarding risk factors, seizure semiology, operative techniques, and tumor characteristics in pediatric patients with a concurrent diagnosis of primary intracranial neoplasm and seizures. To address the limited evidence in current literature
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Does subtotal resection ameliorate hypothalamic morbidity in pediatric craniopharyngioma? A 30-year retrospective cohort study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-11 Omer K. Yousuf, Arsalaan Salehani, Kathrin Zimmerman, Dagoberto Estevez-Ordonez, Casey Madura, Anastasia Arynchyna-Smith, James M. Johnston, Curtis J. Rozzelle, Brandon G. Rocque, Jeffrey P. Blount
OBJECTIVE The optimal extent of resection of craniopharyngiomas to minimize the long-term risks of hypothalamic and endocrine dysfunction (obesity and panhypopituitarism) in children remains uncertain. The purpose of this study was to report long-term outcomes of pediatric patients with craniopharyngioma undergoing surgical treatment and to study rates of endocrinological and hypothalamic dysfunction
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The impact of skull thickness on pediatric stereoencephalography electrode implantation and technical considerations J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-11 Ansh Desai, Akshay Sharma, Swetha J. Sundar, Jason K. Hsieh, Efstathios Kondylis, Arpan Patel, Juan Bulacio, Ajay Gupta, Lara Jehi, William Bingaman
OBJECTIVE One consideration in pediatric stereoencephalography (SEEG) is decreased skull thicknesses compared with adults, which may limit traditional bolt-based anchoring of electrodes. The authors aimed to investigate the safety profile, complication rates, and technical adaptations of placing SEEG electrodes in pediatric patients. METHODS The authors retrospectively reviewed all patients aged 12
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Determinants of epileptogenic zone identification and seizure outcome in children with refractory epilepsy undergoing stereoelectroencephalography J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-11 Jason K. Hsieh, Swetha J. Sundar, Elaine Lu, Ansh Desai, Ajay Gupta, Ahsan N. Moosa, William Bingaman, Lara Jehi, Juan Bulacio
OBJECTIVE The objective of this paper was to investigate the factors associated with successful epileptogenic zone (EZ) identification and postsurgical seizure freedom in pediatric patients with drug-resistant epilepsy who underwent first-time stereoelectroencephalography (SEEG). METHODS The authors conducted a retrospective cohort study of all consecutive patients younger than 18 years of age at the
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Ventriculoatrial and ventriculoperitoneal shunt malfunction and infection in infants with necrotizing enterocolitis J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-08-04 Katherine G. Holste, Jack Vernamonti, Momodou G. Bah, Karin M. Muraszko, Samir K. Gadepalli, Cormac O. Maher, Hugh J. L. Garton
OBJECTIVE Necrotizing enterocolitis (NEC) and posthemorrhagic hydrocephalus are both conditions that can affect preterm infants. The peritoneum is the preferred terminus for shunt placement, but another terminus is sometimes used due to subjective concerns about infection and complications related to NEC. The aim of this study was to examine the rates of ventriculoatrial (VA) and ventriculoperitoneal
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Surgical management of pediatric occipital neuralgia: a single-center experience of an uncommon pathology J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-28 Lance M. Villeneuve, Nangorgo J. Coulibaly, Syed M. Raza, Brittany Poinson, Deepti Chrusciel, Virendra R. Desai
OBJECTIVE Occipital neuralgia (ON) is a rare headache disorder characterized by sharp pain in the distribution of the greater occipital nerve (GON), lesser occipital nerve, or third occipital nerve. ON is commonly associated with traumatic injury, and effective identification and diagnosis can be difficult given the infrequent presentation and similarities to other pediatric headache disorders. While
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Natural history of mild trigonocephalic deformities J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-28 Summer Xu, Nathan K. Leclair, Sophia Angelo, Mitch Paro, Petronella Stoltz, Megan Anderson, Jonathan E. Martin, David S. Hersh, Markus J. Bookland
OBJECTIVE Ridging along the metopic suture line can be a common cause of concern for parents and has been theorized to represent a mild form of trigonocephaly, a cranial deformity associated with risks of negative cosmetic outcomes, if not surgically corrected. Yet the literature contains sparse reports of long-term cosmetic results or expectations for infants with isolated metopic ridging compared
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Clinical characteristics of familial and sporadic pediatric cerebral cavernous malformations and outcomes J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-21 Emade Jaman, Hussein M. Abdallah, Xiaoran Zhang, Stephanie Greene
OBJECTIVE Cerebral cavernous malformation (CCM) is a subtype of the vascular malformations found within the cerebral cortex. Although rare and usually discovered incidentally, these vascular abnormalities can predispose patients to spontaneous cerebral hemorrhage and subsequently lead to a myriad of neurological symptoms at presentation such as seizures and other focal neurological deficits. Although
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Hemispherectomy Outcome Prediction Scale: a validity study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-21 Andrew T. Hale, Dagoberto Estevez-Ordonez, Jana Badrani, Wen Sha, Anastasia Arynchyna-Smith, Monisha Goyal, Ismail Mohamed, Pongkiat Kankirawatana, Curtis J. Rozzelle, Jeffrey P. Blount
OBJECTIVE Hemispherectomy is highly effective for patients with medically refractory epilepsy (MRE) arising from a single hemisphere. Recently, the Hemispherectomy Outcome Prediction Scale (HOPS) was developed as a prediction tool for seizure freedom after hemispherectomy. The authors’ goal was to perform a validation study to determine the generalizability of the HOPS score.METHODS The authors present
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Exploration of clinical predictors of the degree of ventricular catheter obstruction: a multicenter retrospective study J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-21 Prashant Hariharan, Jacob Gluski, Jeffrey Sondheimer, Alexandra Petroj, Andrew Jea, William E. Whitehead, Marc R. Del Bigio, Neena I. Marupudi, James P. McAllister, David D. Limbrick, Brandon G. Rocque, Carolyn A. Harris
OBJECTIVE The aim of this study was to explore how clinical factors, including the number of lifetime revision surgeries and the duration of implantation, affect the degree of obstruction and failure rates of ventricular catheters (VCs) used to manage hydrocephalus.METHODS A total of 343 VCs and their associated clinical data, including patient demographics, medical history, and surgical details, were
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Racial differences in the care of pediatric sagittal craniosynostosis: a single-institution cohort study affecting state Medicaid policy J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-14 S. Hassan A. Akbari, James Mooney, Jacob Lepard, Anastasia Arynchyna-Smith, Samuel McClugage, Rene Myers, John Grant, Curtis Rozzelle, James M. Johnston
OBJECTIVE Although research has shown the cost-effectiveness of endoscopic versus open repair of sagittal synostosis, few studies have shown how race, insurance status, and area deprivation impact care for these patients. The authors analyzed data from children evaluated for sagittal synostosis at a single institution to assess how socioeconomic factors, race, and insurance status affect the surgical
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School-age anthropometric and patient-reported outcomes after open or endoscopic repair of sagittal craniosynostosis J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-14 Annahita R. Fotouhi, Kamlesh B. Patel, Gary B. Skolnick, Corinne M. Merrill, Katherine M. Hofmann, Esperanza Mantilla-Rivas, Brent R. Collett, Virginia D. Allhusen, Sybill D. Naidoo, Gary F. Rogers, Robert F. Keating, Matthew D. Smyth, Suresh N. Magge
OBJECTIVE Several studies have compared perioperative parameters and early postoperative morphology between endoscope-assisted strip craniectomy with orthotic therapy (endoscopic repair) and cranial vault remodeling (open repair). To extend these results, the authors evaluated school-age anthropometric outcomes after these techniques across three institutions.METHODS School-aged children (age range
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Feasibility of probe washing after stereotactic needle biopsy as a novel technique for developing cell lines and xenografts of H3 K27–altered diffuse midline gliomas J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-14 Julian S. Rechberger, Liang Zhang, Jizhi Ge, Cody L. Nesvick, Kai J. Miller, David J. Daniels
H3 K27–altered diffuse midline gliomas (DMGs) are frequently biopsied to obtain tissue diagnosis, inform clinical decision-making, and determine clinical trial eligibility. Tissue yield from biopsies is typically low, leaving little material available for research. To advance understanding of disease biology and promote preclinical testing of novel therapeutics, collecting viable cellular material
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Intracranial invasive group A streptococcus: a neurosurgical emergency in children J. Neurosurg. Pediatr. (IF 2.713) Pub Date : 2023-07-07 Dana Hutton, Michelle Kameda-Smith, Fardad T. Afshari, Ahmed Elawadly, Florence Hogg, Samir Mehta, James Samarasekara, Kristian Aquilina, Noor ul Owase Jeelani, M. Zubair Tahir, Dominic Thompson, Martin M. Tisdall, Adikarige Haritha Dulanka Silva, James Hatcher, Greg James
OBJECTIVE Invasive group A streptococcus (iGAS) infections are associated with a high rate of morbidity and mortality. CNS involvement is rare, with iGAS accounting for only 0.2%–1% of all childhood bacterial meningitis. In 2022, a significant increase in scarlet fever and iGAS was reported globally with a displacement of serotype, causing a predominance of the emm1.0 subtype. Here, the authors report