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Social withdrawal behaviour in Nepalese infants and the relationship with future neurodevelopment; a longitudinal cohort study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-18 Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Ram K. Chandyo, Antoine Guedeney, Hanne C. Braarud, Mari Hysing, Tor A. Strand
Social withdrawal in infants may be a signal of distress and a precursor for non-optimal development. To examine the relationship between infant social withdrawal and neurodevelopment up to 4 years in Nepalese children. A total of 597 Nepalese infants 6–11 months old were assessed with the modified Alarm Distress Baby Scale (m-ADBB), and of these, 527 with the Bayley Scales of Infant and Toddler Development
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Infantile-onset pompe disease: a case report emphasizing the role of genetic counseling and prenatal testing BMC Pediatr. (IF 2.4) Pub Date : 2024-03-18 Yasaman Alizadeh, Hossein Saidi, Vahid Saeedi, Leila Kamalzadeh
Pompe disease, classified as glycogen storage disease type II, arises from a deficiency in the acid alpha-glucosidase (GAA) enzyme, leading to glycogen accumulation in multiple tissues. The unique correlation between genotype and enzyme activity is a key feature. This case highlights an infantile-onset form, emphasizing genetic counseling and prenatal testing importance. An 18-week-old infant with
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Gut microbiota profiling in obese children from Southeastern China BMC Pediatr. (IF 2.4) Pub Date : 2024-03-18 Jingjing Wang, Peifeng Zhuang, Bin Lin, Haiqing Li, Jinlu Zheng, Wenlin Tang, Wenbin Ye, Xiangjian Chen, Mingping Zheng
Childhood obesity not only has a negative impact on a child's health but is also a significant risk factor for adult obesity and related metabolic disorders, making it a major global public health concern. Recent studies have revealed the crucial role of gut microbiota in the occurrence and development of obesity, in addition to genetic and lifestyle factors. In this study, we recruited 19 normal-weight
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Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: a systematic review and meta-analysis BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Xin Yang, Min Chai, Meng Lin
The impact of vitamin D on type 1 diabetes has been a controversial topic in public health. Furthermore, significant differences in the proportion of vitamin D have been noted. The purpose of this systematic review was to determine the overall proportion of vitamin D deficiency in children/adolescents with type 1 diabetes (T1D). Based on six electronic databases (PubMed, Web of Science, Embase, Ovid
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The assessment of preschool children with ESSENCE symptoms: concordance between parents, preschool teachers and child psychologists BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 B. M. Gustafsson, M. Sund Levander
It is important to detect children with Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations (ESSENCE) in order to implement early intervention and support for the child and family. Standardized instruments for assessment in different contexts of behaviour problems, engagement and psychosocial health obtain an objective picture of the preschool child's mental health. To explore
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NLRC4 methylation and its response to intravenous immunoglobulin therapy in Kawasaki disease: a case control study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Beirong Yu, Bangxu Zheng, Yu Shen, Yijing Shen, Haiyan Qiu, Ling Wu, Yuanling Chen, Xiaohong Cai, Junhua Wu, Qingxiao Hong
Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD Domain Containing 4 (NLRC4) encodes the key components of inflammasomes that function as pattern recognition receptors. The purpose of this study was to investigate the potential
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Aberrant SOX10 and RET expressions in patients with Hirschsprung disease BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Gunadi, Verrell Christopher Amadeus, Fadila Dyah Trie Utami, Fiqih Vidiantoro Halim, Nabilah Anisa Novebri, Rahaditya Alrasyidi Hanggoro, Avinindita Nura Lestari, Kristy Iskandar, Andi Dwihantoro, Eko Purnomo
HSCR is a complex genetic disorder characterized by the absence of ganglion cells in the intestine, leading to a functional obstruction. It is due to a disruption of complex signaling pathways within the gene regulatory network (GRN) during the development of the enteric nervous system (ENS), including SRY-Box Transcription Factor 10 (SOX10) and REarranged during Transfection (RET). This study evaluated
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Awareness and healthcare seeking behavior of neonatal danger signs, and predictor variables among mothers/caregivers in four developing regional state of Ethiopia BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Nagasa Dida, Lonsako Abute, Tariku Dejene, Tolasa Yadate, Temesgen Geleta, Rachana Sharma, Hnin Su Mon, Tesfaye Simireta, Hailemariam Addisu
: Mothers/caregivers should be aware of a newborn’s danger signs and promptly seek medical attention. Hence, this study assessed mothers’/caregivers’ awareness, healthcare seeking behaviors for neonatal danger signs and their determinants in the developing regional state of Ethiopia. A community-based cross-sectional study was employed among mothers/caregivers of neonates in the developing regional
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Postnatal care and acceptability of emollient therapy in very low birthweight infants in Harare, Zimbabwe: a qualitative analysis BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Alexa Hui, Gwendoline Chimhini, Margaret Saungweme, Dorah Kaisi, Elisabeth Munetsi, Hilda A. Mujuru, Gary L. Darmstadt
Preterm birth (birth before 37 completed weeks of pregnancy) is the leading cause of neonatal and child under-five mortality globally, both of which are highest regionally in sub-Saharan Africa. The skin barrier plays a critical role in neonatal health and increasing evidence supports the use of topical emollient therapy to promote postnatal growth and reduce hospital-acquired infections in preterm
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Clinical features and treatment options for pediatric adrenal incidentalomas: a retrospective single center study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Xiaojiang Zhu, Saisai Liu, Yimin Yuan, Nannan Gu, Jintong Sha, Yunfei Guo, Yongji Deng
The aim of this study was to investigate the clinical features and treatment options for pediatric adrenal incidentalomas(AIs) to guide the diagnosis and treatment of these tumors. The clinical data of AI patients admitted to our hospital between December 2016 and December 2022 were collected and retrospectively analyzed. All patients were divided into neonatal and nonneonatal groups according to their
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Relationship between vitamin D levels and pediatric celiac disease: a systematic review and meta-analysis BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Yanhong Sun, Qingxue Zhou, Dandan Tian, Jianming Zhou, Shilei Dong
The relationship between Vitamin D levels and pediatric celiac disease (CD) remains controversial. In this study, we conducted a systematic review and meta-analysis to examine the relationship between Vitamin D and pediatric CD. Methods: We screened relevant studies from PubMed, EMBASE, and Web of Science published in English from January 1, 2000, to August 1, 2023. The included studies were assessed
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The footprint of SARS-COV-2 infection in neonatal late sepsis BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Zahra Jamali, Najmeh Mohammadpour, Reza Sinaei, Maedeh Jafari, Fatemeh Sabzevari, Mohammad Hasannejad
Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging. In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time
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Values of serum intestinal fatty acid-binding protein, fecal calprotectin, and fecal human β-defensin 2 for predicting necrotizing enterocolitis BMC Pediatr. (IF 2.4) Pub Date : 2024-03-16 Sujia Liu, Yongle Liu, Shuhua Lai, Yingling Xie, Wenlong Xiu, Changyi Yang
This study aimed to assess the diagnostic potential of serum intestinal fatty acid-binding protein (I-FABP), fecal calprotectin (FC), and fecal human β-defensin 2 (hBD2) in predicting necrotizing enterocolitis (NEC) in preterm infants. A prospective cohort of neonates with a gestational age < 32 weeks, suspected of NEC, was enrolled between June 2021 and December 2022. Serum I-FABP, FC, and fecal hBD2
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Novel PIP5K1C variant identified in a Chinese pedigree with lethal congenital contractural syndrome 3 BMC Pediatr. (IF 2.4) Pub Date : 2024-03-15 Fang Zhang, Hongmei Guo, Xinlong Zhou, Zhengxi Deng, Qiuhong Xu, Qingming Wang, Haiming Yuan, Jianhua Luo
Biallelic pathogenic variants in PIP5K1C (MIM #606,102) lead to lethal congenital contractural syndrome 3 (LCCS3, MIM #611,369), a rare autosomal recessive genetic disorder characterized by small gestational age, severe multiple joint contractures and muscle atrophy, early death due to respiratory failure. Currently, 5 individuals with LCCS3 were reported and 5 pathogenic variants in PIP5K1C were identified
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Persian version of brief infant sleep questionnaire (BISQ): a psychometric evaluation BMC Pediatr. (IF 2.4) Pub Date : 2024-03-15 Maryam Yazdi, Maryam Bemanalizadeh, Roya Kelishadi
The high prevalence of sleep problems and their negative consequences on children and parents highlight the need to design early screening instruments to evaluate sleep problems in early childhood. We aimed to determine the validity and reliability of the Brief Infant Sleep Questionnaire (BISQ) among the Iranian population. This study included 646 one-year-old infants by random sampling from the PERSIAN
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Diabetes-related instrument to assess preventive behaviors among adolescents (DIAPBA): a tool development and psychometric research BMC Pediatr. (IF 2.4) Pub Date : 2024-03-15 Ameneh Pooresmaeil Dorosteh, Mohtasham Ghaffari, Sakineh Rakhshanderou, Yadollah Mehrabi
Type 2 diabetes is a chronic but preventable disease that is on the rise among adolescents. Evaluating adolescents’ behavior and planning to prevent it require a valid and reliable instrument. This study aims at designing a psychometric instrument to measure adolescents’ behavior with respect to type-2 diabetes. In this methodological research, 770 students (adolescent boys and girls aged 13–15 years)
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Multisystem inflammatory syndrome in children (MIS-C) post-COVID-19 in Iran: clinical profile, cardiac features, and outcomes BMC Pediatr. (IF 2.4) Pub Date : 2024-03-13 Ali Hoseininasab, Reza Sinaei, Mohammad Mehdi Bagheri, Maryam Ahmadipour, Reza Derakhshan, Mohammad Javad Najafzadeh, Fatemeh Karami Robati, Maedeh Jafari, Sarehossadat Ebrahimi, Mohammad Ali Jafari
In April 2020, an association between multisystem inflammatory syndromes (MIS-C) was observed in children with severe acute respiratory syndrome coronavirus infection (SARS-CoV-2). Most patients had heart involvement alone, and most patients had pericardial effusion. This study aimed to express and emphasize cardiac involvement in pediatric patients with respiratory symptoms who were diagnosed with
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Correlation analysis between the amniotic fluid contamination and clinical grading of neonatal hypoxic–ischemic encephalopathy and biomarkers of brain damage BMC Pediatr. (IF 2.4) Pub Date : 2024-03-13 Hongyan Lv, Fang Liu, Qiuli Wang, Zhiyong Dong, Huiming Zhang, Pengshun Ren, Liangxiang Li
Amniotic fluid contamination (AFC) is a risk factor for neonatal hypoxic ischemic encephalopathy (HIE); however, the correlation between AFC level and the incidence and clinical grading of HIE, in addition to relevant biomarkers of brain damage, have not been assessed. This single-center observational study included 75 neonates with moderate-to-severe HIE. The neonates with HIE were divided into four
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Use of antimicrobials in pediatric wards of five Brazilian hospitals BMC Pediatr. (IF 2.4) Pub Date : 2024-03-13 Thais de Barros Fernandes, Sheila Feitosa Ramos, Luísa Rodrigues Furtado Leitzke, Ronaldo Gomes Alexandre Júnior, Janaína Morais de Araújo, Alcidésio Sales de Souza Júnior, Alice Ramos Oliveira da Silva, Isabela Heineck, Marta Maria de França Fonteles, Louise E. Bracken, Matthew Peak, Divaldo Pereira de Lyra Junior, Claudia G S Osorio-de-Castro, Elisangela Costa Lima
The use of antimicrobials (AMs) in pediatric infections is common practice and use may be inappropriate leading to antimicrobial resistance. Off-label AM use is also common in this group and can result in drug-related problems. There is lack of DUR data in Brazil and in Latin America, specially for AM pediatric use. The aim of this study was to describe the utilization of AMs in hospitalized children
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Quantifying health facility service readiness for small and sick newborn care: comparing standards-based and WHO level-2 + scoring for 64 hospitals implementing with NEST360 in Kenya, Malawi, Nigeria, and Tanzania BMC Pediatr. (IF 2.4) Pub Date : 2024-03-12 Rebecca E. Penzias, Christine Bohne, Edith Gicheha, Elizabeth M. Molyneux, David Gathara, Samuel K. Ngwala, Evelyn Zimba, Ekran Rashid, Opeyemi Odedere, Olabisi Dosunmu, Robert Tillya, Josephine Shabani, James H. Cross, Christian Ochieng, Harriet H. Webster, Msandeni Chiume, Queen Dube, John Wainaina, Irabi Kassim, Grace Irimu, Steve Adudans, Femi James, Olukemi Tongo, Veronica Chinyere Ezeaka, Nahya
Service readiness tools are important for assessing hospital capacity to provide quality small and sick newborn care (SSNC). Lack of summary scoring approaches for SSNC service readiness means we are unable to track national targets such as the Every Newborn Action Plan targets. A health facility assessment (HFA) tool was co-designed by Newborn Essential Solutions and Technologies (NEST360) and UNICEF
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The association of dietary carbohydrate quality and quantity with obesity among Iranian adolescents: a case-control study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-09 Shabnam Mohebati, Mahboobeh Shakeri, Sara Ranjbar, Mohammad Jalali, Mehran Nouri, Shiva Faghih
Adolescent obesity is considered as a major health concern worldwide which is closely linked to the quality of diet. The purpose of the present study was to assess the carbohydrate quality and quantity in relation to odds of overweight and obesity in adolescents. This case-control study with a 1:1 ratio was conducted on 406 adolescents (14 to 18 years old) matched for age and gender. Participants were
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Primary-school-aged children inspire their peers and families to eat more vegetables in the KiiDSAY project: a qualitative descriptive study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-09 Karpouzis F., Walsh A., Shah S., Ball K., Lindberg R.
While vegetable intakes in Australia remain sub-optimal across all age groups, children are rarely consulted about their ideas on how to increase consumption. Qualitative research involving children provides an opportunity to consider their views. The aim of the Kids initiative inspires Dietary Success in Adults and Youth (KiiDSAY) project was to explore the views of school-aged children, who had participated
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Study protocol for the ACTIVE SCHOOL study investigating two different strategies of physical activity to improve academic performance in Schoolchildren BMC Pediatr. (IF 2.4) Pub Date : 2024-03-09 Lise Sohl Jeppesen, Linn Damsgaard, Malene Norup Stolpe, Jesper Ninn Sandfeld Melcher, Jacob Wienecke, Glen Nielsen, Søren Smedegaard, Anne Husted Henriksen, Rasmus Ahmt Hansen, Charles H Hillman, Tuija H Tammelin, Geir K Resaland, Andrew Daly-Smith, Anna Bugge
Previous research has suggested that school-based physical activity (PA) interventions may have a positive impact on academic performance. However, existing literature on school-based interventions encompasses various forms of PA, spanning from vigorous intensity PA outside the academic classes to light intensity PA and movement integrated into academic learning tasks, and results on academic performance
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Vacuum bell therapy for pectus excavatum: a retrospective study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-09 Weixuan Lei, Mengqi Shao, Yan Hu, Jieming Cao, Wei Han, Ruoyao Wang, Quanming Fei, Jian Zou, Junqi Yi, Zheyu Cheng, Wenliang Liu
Pectus excavatum, the most common chest wall deformity, is frequently treated with Nuss procedure. Here we will describe non-invasive procedure and analyze the variables associated vacuum bell therapy for patients with pectus excavatum. Retrospective case–control study in a single center between July 2018 and February 2022, including patients with pectus excavatum treated with vacuum bell. Follow-up
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The role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Kun-Yao Hong, Yao Zhu, Fan Wu, Jian Mao, Ling Liu, Rong Zhang, Yan-Mei Chang, Wei Shen, Li-Xia Tang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Zhi Zheng, Xiao-Mei Tong, Xin-Zhu Lin
Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze the risk factors for LO-NEC, and the impact of LO-NEC on short-term outcomes in very preterm infants
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Effect of early preventive supplementation with calcium and phosphorus on metabolic bone disease in premature infants BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Xuejing Xu, Hongfang Ma, Shuqi Cheng, Jiang Xue
The objective was to study the effect of early preventive calcium and phosphorus supplementation on metabolic bone disease in preterm infants. A retrospective analysis of 234 preterm infants with a gestational age < 32 weeks or birth weight < 1500 g who were hospitalized in the Neonatology Department of the Second Hospital of Shandong University from 01.2018 to 12.2020 was conducted. One hundred thirty-two
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Mortality and associated factors among children admitted to an intensive care unit in muhimbili national hospital, from the time of admission to three months after discharge: a prospective cohort study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Rehema E. Lyimo, Yasser H. Said, Sokoine L. Kivuyo, Deogratias Nkya, Francis F. Furia
Mortality of children admitted to Intensive Care Units (ICU) is higher in low-to-middle-income countries (LMICs) as compared to high-income countries (HICs). There is paucity of information on outcomes following discharge from ICU, especially from sub-Saharan Africa region. This study was conducted to determine mortality and its associated factors among children admitted to Pediatric ICU (PICU) at
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Association between textual and pictorial warnings on tumbac (waterpipe tobacco) boxes and motivation to quit waterpipe smoking among Lebanese and Iraqi adolescents BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Diana Malaeb, Bassam Abdul Rasool Hassan, Ali Haider Mohammed, Sinan Subhi Farhan, Omar Abdulwahid Al-Ani, Abir Sarray El Dine, Feten Fekih-Romdhane, Sahar Obeid, Souheil Hallit
Waterpipe tobacco smoking has increased tremendously at a global level among all age groups, particularly young people. Previous studies have examined the impact of waterpipe tobacco pictorial health warnings on adults but scarce studies were done on adolescents. The aim of this study was to assess the association of textual versus pictorial warnings on tumbac boxes and the motivation to quit waterpipe
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Population-based cross-sectional study of factors influencing full vaccination status of children aged 12- 23 months in a rural district of the Upper East Region, Ghana BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Emmanuel Awonanya Akanpaabadai, Abraham Awonboro Adiak, Ruth Nimota Nukpezah, Martin Nyaaba Adokiya, Simon Effah Adjei, Michael Boah
Achieving universal health coverage includes ensuring that children have access to vaccines that are of high quality, safe, efficacious, and affordable. The Immunisation Agenda 2030 aims to expand services to zero-dose and incompletely vaccinated children and reduce immunisation rate disparities as a contribution to vaccination equity. This study explored the factors influencing full vaccination status
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Association between parental feeding styles, body mass index, and consumption of fruits, vegetables and processed foods with mothers´ perceptions of feeding difficulties in children BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Nathalia Moretti Fontanezi, Priscila Maximino, Rachel Helena Vieira Machado, Gerson Ferrari, Mauro Fisberg
Feeding difficulties (FDs) are complex phenomena influenced by parental factors, feeding behaviour, and cultural factors. However, studies of the influences of these factors on FDs incidence are scarce. Thus, this study aimed to identify the associations between mothers’ perceptions of FDs in children and parental feeding styles, body mass index, and the consumption of fruits, vegetables and processed
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The first pineoblastoma case report of a patient with Sotos syndrome harboring NSD1 germline mutation BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Xizan Yue, Bo Liu, Tiantian Han, Didi Guo, Ran Ding, Guangyu Wang
Germline mutations of NSD1 are associated with Sotos syndrome, characterized by distinctive facial features, overgrowth, and developmental delay. Approximately 3% of individuals with Sotos syndrome develop tumors. In this study, we describe an infant in pineoblastoma with facial anomalies, learning disability and mild autism at 1 years diagnosed as Sotos syndrome owing to carrying a novel mutation
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Parental engagement in research on paediatric lower respiratory tract infections in Indonesia BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Vincentia Rizke Ciptaningtyas, Tanjung Ayu Sumekar, Quirijn de Mast, Marinus Isaäk de Jonge, Ani Margawati
Lower respiratory tract infections (LRTIs) in children are a major concern in Indonesia as it is the leading cause of morbidity and mortality. Therefore, research on LRTIs is crucial to improve children’s health. However, clinical research in children is challenging due to parental concerns. This study aims to understand parental considerations for taking part in clinical studies on LRTI in the Indonesian
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Movement behaviour education for parents in prenatal, postnatal, and pediatric care in Canada: A needs assessment BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Brianne A. Bruijns, Matthew Bourke, Aidan Loh, Patricia Tucker
Parents/guardians can greatly influence their child’s movement behaviours (i.e., physical activity, sedentary behaviour, and sleep). Yet, they have reported to lack sufficient background knowledge to foster healthy movement habits, and little is known about specific educational gaps. The aim of this study was to explore the educational background and needs regarding promoting healthy movement behaviours
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Health-related quality of life and self-reported health status in adolescents with chronic health conditions before transfer of care to adult health care: an international cohort study BMC Pediatr. (IF 2.4) Pub Date : 2024-03-08 Mira Kallio, Anna Tornivuori, Päivi J. Miettinen, Kaija-Leena Kolho, Heikki Relas, Evelyn Culnane, Hayley Loftus, Susan M. Sawyer, Silja Kosola
Heath-related quality of life (HRQoL) is lower in adolescents with chronic health conditions compared to healthy peers. While there is evidence of some differences according to the underlying condition and gender, differences by measure and country are poorly understood. In this study we focus on the differences in HRQoL in adolescents with various chronic medical conditions in the year before transfer
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Health facility assessment of small and sick newborn care in low- and middle-income countries: systematic tool development and operationalisation with NEST360 and UNICEF BMC Pediatr. (IF 2.4) Pub Date : 2024-03-07 Rebecca E. Penzias, Christine Bohne, Samuel K. Ngwala, Evelyn Zimba, Norman Lufesi, Ekran Rashid, Edith Gicheha, Opeyemi Odedere, Olabisi Dosunmu, Robert Tillya, Josephine Shabani, James H. Cross, Sara Liaghati-Mobarhan, Msandeni Chiume, George Banda, Alfred Chalira, John Wainaina, David Gathara, Grace Irimu, Steve Adudans, Femi James, Olukemi Tongo, Veronica Chinyere Ezeaka, Georgina Msemo, Nahya
Each year an estimated 2.3 million newborns die in the first 28 days of life. Most of these deaths are preventable, and high-quality neonatal care is fundamental for surviving and thriving. Service readiness is used to assess the capacity of hospitals to provide care, but current health facility assessment (HFA) tools do not fully evaluate inpatient small and sick newborn care (SSNC). Health systems
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Clinical characteristics and prognoses in pediatric neuroblastoma with bone or liver metastasis: data from the SEER 2010–2019 BMC Pediatr. (IF 2.4) Pub Date : 2024-03-07 Xudong Zhao, Zhuofan Xu, Xiaochuan Feng
To investigate clinical characteristics, prognoses, and impacts of treatments on prognoses of neuroblastoma patients with bone or liver metastasis. This retrospective cohort study extracted data from the Surveillance, Epidemiology, and End Results (SEER) database 2010–2019. The outcomes were 3-year cancer-specific survival (CSS) and 5-year CSS. Multivariable COX risk proportional models were established
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Importance about use of high-throughput sequencing in pediatric: case report of a patient with Fanconi-Bickel syndrome BMC Pediatr. (IF 2.4) Pub Date : 2024-03-07 Hugo Hernán Abarca-Barriga, María Cristina Laso-Salazar, Diego Orihuela-Tacuri, Jenny Chirinos-Saire, Anahí Venero-Nuñez
Fanconi-Bickel syndrome is characterized by hepatorenal disease caused by anomalous glycogen storage. It occurs due to variants in the SLC2A2 gene. We present a male patient of 2 years 7 months old, with failure to thrive, hepatomegaly, metabolic acidosis, hypophosphatemia, hypokalemia, hyperlactatemia. Exome sequencing identified the homozygous pathogenic variant NM_000340.2(SLC2A2):c.1093 C > T (p
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Novel CAD gene mutations in a boy with developmental and epileptic encephalopathy 50 with dramatic response to uridine therapy: a case report and a review of the literature BMC Pediatr. (IF 2.4) Pub Date : 2024-03-07 Lifen Duan, Lei Ye, Runxiu Yin, Ying Sun, Wei Yu, Yi Zhang, Haiyan Zhong, Xinhua Bao, Xin Tian
Developmental and epileptic encephalopathy-50 (DEE-50) is a rare clinical condition believed to be caused by a mutation in the CAD gene and is associated with a bleak prognosis. CAD-related diseases have a wide range of clinical manifestations and other symptoms that may be easily overlooked. Like other rare diseases, the clinical manifestations and the treatment of DEE-50 necessitate further investigation
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Associations of sleep time, quality of life, and obesity indicators on physical literacy components: a structural equation model BMC Pediatr. (IF 2.4) Pub Date : 2024-03-07 Vanilson Batista Lemes, Ana Paula Sehn, Cézane Priscila Reuter, Ryan Donald Burns, Anelise Reis Gaya, Adroaldo Cesar Araujo Gaya, Caroline Brand
To verify the association between ideal sleep time and physical literacy components while also considering multiple mediators, such as quality of life and obesity, using a sample of adolescents. This cross-sectional study consisted of 470 adolescents aged 11–17 years from southern Brazil. Sleep time, health-related quality of life, and physical literacy components (i.e., physical education enjoyment
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Prediction of coronary artery lesions in children with Kawasaki syndrome based on machine learning BMC Pediatr. (IF 2.4) Pub Date : 2024-03-05 Yaqi Tang, Yuhai Liu, Zhanhui Du, Zheqi Wang, Silin Pan
Kawasaki syndrome (KS) is an acute vasculitis that affects children < 5 years of age and leads to coronary artery lesions (CAL) in about 20-25% of untreated cases. Machine learning (ML) is a branch of artificial intelligence (AI) that integrates complex data sets on a large scale and uses huge data to predict future events. The purpose of the present study was to use ML to present the model for early
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Relationship between chorioamnionitis or funisitis and lung injury among preterm infants: meta-analysis involved 16 observational studies with 68,397 participants BMC Pediatr. (IF 2.4) Pub Date : 2024-03-05 Wen-li Liu, Yao Zhou, Chao Zhang, Jun Chen, Xu-feng Yin, Feng-xia Zhou, Shao-jun Chen
Chorioamnionitis (CA) can cause multiple organ injuries in premature neonates, particularly to the lungs. Different opinions exist regarding the impact of intrauterine inflammation on neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD). We aim to systematically review the relationship between CA or Funisitis (FV) and lung injury among preterm infants. We electronically
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Influenza a H1N1 infection complicated with encephalopathy and acute pancreatitis: a case report BMC Pediatr. (IF 2.4) Pub Date : 2024-03-05 Junhao Cui, Wanyu Jia, Peng Li, Xue Zhang, Zheng Li, Chunlan Song
This paper reports a case of influenza complicated with influenza associated encephalopathy complicated with acute pancreatitis. This kind of disease is relatively rare, we hope to draw people’s attention to it in order to improve early detection and prognosis.
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The effect of oropharyngeal mother’s milk on nutritional outcomes in preterm infants: a randomized controlled trial BMC Pediatr. (IF 2.4) Pub Date : 2024-03-04 Fatemeh Kelich, Mojtaba Qanbari Qalehsari, Ali Zabihi, Seyedeh Roghayeh Jafarian Amiri, Navid Danaee
Oropharyngeal interventions are an accepted method to improve the nutritional performance of premature infants. Considering the countless benefits of breast milk and the few studies on the use of breast milk as an oral-pharyngeal intervention, this study was conducted with the aim of determining the effect of oral-pharyngeal administration of breast milk on nutritional outcomes in premature infants
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The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5−ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Yunying Zhu, Qian Jiang, Chenshuang Lei, Qinhua Yu, Liannv Qiu
Allergic asthma is a type I allergic reaction mediated by serum Immunoglobulin E (IgE). B cell-mediated humoral immune response to allergens in the pathophysiology of allergic asthma have not been thoroughly elucidated. Peripheral helper T cells (Tph) and follicular helper T cells (Tfh) promote B cell differentiation and antibody production in inflamed tissues. To investigate the roles of B cell subsets
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Risk factors of multidrug-resistant organisms neonatal sepsis in Surabaya tertiary referral hospital: a single-center study BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Stefani Miranda, Aminuddin Harahap, Dominicus Husada, Fara Nayo Faramarisa
Bacterial organisms causing neonatal sepsis have developed increased resistance to commonly used antibiotics. Antimicrobial resistance is a major global health problem. The spread of Multidrug-Resistant Organisms (MDROs) is associated with higher morbidity and mortality rates. This study aimed to determine the risk factors for developing MDRO neonatal sepsis in the Neonatal Intensive Care Unit (NICU)
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The impact of blood lactic acid levels on retinopathy of prematurity morbidity BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Congcong Zhao, Zhihong Sun, Hongming Chen, Kaili Li, Huiqing Sun
Retinopathy of prematurity (ROP) is a common disease in premature infants. In recent years, most researchers have used lactic acid as poor prognosis marker in premature infants. This study aims to explore investigate the impact of blood lactic acid levels on ROP. A retrospective case-control study was conducted, and infants with severe ROP born with birth weight (BW) ≤ 1500 g and gestational age (GA) ≤ 32
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Minimum acceptable diet and associated factors among children aged 6–23 months in Ethiopia: a systematic review and meta-analysis BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Kedir Abdela Gonete, Dessie Abebaw Angaw, Lemma Derseh Gezie
To ensure a child's full growth, health, and development during infancy and the early years, adequate nutrition is crucial. A crucial window of opportunity for ensuring children's proper growth and development through adequate eating exists during the first two years of life. According to the evidence of the efficacy of interventions, achieving universal coverage of optimal breastfeeding could prevent
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Predictors of prolonged length of hospital stay and in-hospital mortality in patients aged 1–24 months with acute bronchiolitis in Douala, Cameroon BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Charlotte Eposse Ekoube, Emmanuel Heles Nsang, Patricia Épée, Edgar Mandeng Ma Linwa, Yolande Djike Puepi, Ritha Mbono Betoko, Diomède Noukeu Njinkui, Dominique Enyama, Dora Mbonjo Bitsie, Jeannette Disso Massako, Soumaiyatou Abba, Esther Eleonore Ngo Linwa, Calixte Ida Penda
In Cameroon, acute bronchiolitis has been reported as the third commonest lower respiratory infection and is usually associated with low mortality. Nonetheless, respiratory distress associated with non-adherence to management guidelines can prolong hospital stay. This study aimed to explore predictors of prolonged hospital stay (≥ 5 days) and mortality in patients aged < 2years hospitalised for acute
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Individualized estimation of arterial carbon dioxide partial pressure using machine learning in children receiving mechanical ventilation BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Hye-Ji Han, Bongjin Lee, June Dong Park
Measuring arterial partial pressure of carbon dioxide (PaCO2) is crucial for proper mechanical ventilation, but the current sampling method is invasive. End-tidal carbon dioxide (EtCO2) has been used as a surrogate, which can be measured non-invasively, but its limited accuracy is due to ventilation-perfusion mismatch. This study aimed to develop a non-invasive PaCO2 estimation model using machine
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Factors influencing necrotizing enterocolitis in premature infants in China: a systematic review and meta-analysis BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Shuliang Zhao, Huimin Jiang, Yiqun Miao, Wenwen Liu, Yanan Li, Hui Liu, Aihua Wang, Xinghui Cui, Yuanyuan Zhang
Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity and mortality among premature infants. However, studies with large samples on the factors of NEC in China have not been reported. This meta-analysis aims to systematically review the literature to explore the influencing factors of necrotizing enterocolitis in premature infants in China and provide a reference
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Two cases of small bowel necrosis due to intussusception secondary to abnormal proliferation of intestinal Peyer’s patches in infants after MMR vaccination BMC Pediatr. (IF 2.4) Pub Date : 2024-02-29 Junzhao Zhu, Weiping Cheng, Youbo Xu, Yingqiang Guo, Lexiang Shi
Intussusception is one of the most common acute abdominal conditions in pediatric patients, and if left untreated, it may result in intestinal necrosis and even death. The etiology of the disease is unknown and may be related to a variety of factors, and there are only limited reports of small bowel necrosis secondary to abnormal Peyer’s node hyperplasia after MMR vaccination. In this report, we present
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Using implementation research to understand lessons in reducing child mortality BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Agnes Binagwaho, Lisa R. Hirschhorn
Under-5 mortality decreased significantly worldwide between 2000 and 2015, but there is still progress to be made, particularly in lower- and middle-income countries. This supplement shares the work over the last four years on a project to understand how six countries (Bangladesh, Ethiopia, Nepal, Peru, Rwanda, and Senegal) were more successful in decreasing child mortality than many of their regional
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Examining the implementation of facility-based integrated management of childhood illness and insecticide treated nets in Bangladesh: lessons learned through implementation research BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Fauzia Akhter Huda, Kedest Mathewos, Hassan Rushekh Mahmood, Omar Faruk, Lisa R. Hirschhorn, Agnes Binagwaho
Bangladesh significantly reduced under-5 mortality (U5M) between 2000 and 2015, despite its low economic development and projected high mortality rates in children aged under 5 years. A portion of this success was due to implementation of health systems-delivered evidence-based interventions (EBIs) known to reduce U5M. This study aims to understand how Bangladesh was able to achieve this success between
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Cross-country analysis of contextual factors and implementation strategies in under-5 mortality reduction in six low- and middle-income countries 2000–2015 BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Agnes Binagwaho, Amelia VanderZanden, Patricia J. Garcia, Fauzia Akhter Huda, Mahesh Maskey, Mohamadou Sall, Felix Sayinzoga, Raj Kumar Subedi, Alula M. Teklu, Kateri Donahoe, Miriam Frisch, Jovial Thomas Ntawukuriryayo, Kelechi Udoh, Lisa R. Hirschhorn
The Exemplars in Under-5 Mortality (U5M) was a multiple cases study of how six low- and middle-income countries (LMICs), Bangladesh, Ethiopia, Nepal, Peru, Rwanda, and Senegal, implemented health system-delivered evidence-based interventions (EBIs) to reduce U5M between 2000 and 2015 more effectively than others in their regions or with similar economic growth. Using implementation research, we conducted
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Inequity in the face of success: understanding geographic and wealth-based equity in success of facility-based delivery for under-5 mortality reduction in six countries BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Jovial Thomas Ntawukuriryayo, Amelia VanderZanden, Alemayehu Amberbir, Alula Teklu, Fauzia Akhter Huda, Mahesh Maskey, Mohamadou Sall, Patricia J. Garcia, Raj Kumar Subedi, Felix Sayinzoga, Lisa R. Hirschhorn, Agnes Binagwaho
Between 2000–2015, many low- and middle-income countries (LMICs) implemented evidence-based interventions (EBIs) known to reduce under-5 mortality (U5M). Even among LMICs successful in reducing U5M, this drop was unequal subnationally, with varying success in EBI implementation. Building on mixed methods multi-case studies of six LMICs (Bangladesh, Ethiopia, Nepal, Peru, Rwanda, and Senegal) leading
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Embedded implementation research in programming at scale – the new normal to be! BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Stefan Swartling Peterson
If you want to run faster, don’t just buy a new pair of shoes; also consider your training methods and where you run. This supplement examines six countries that have run faster than others in reducing under-five mortality, taking an implementation research approach, with country case studies done with local researchers and local institutions. Key generalizable learnings are to choose and adapt implementation
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Understanding rapid implementation from discovery to scale: Rwanda’s implementation of rotavirus vaccines and PMTCT in the quest to reduce under-5 mortality BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Felix Sayinzoga, Lisa R. Hirschhorn, Jovial Thomas Ntawukuriryayo, Caroline Beyer, Kateri B. Donahoe, Agnes Binagwaho
Over the last eight decades, many evidence-based interventions (EBIs) have been developed to reduce amenable under-5 mortality (U5M). Implementation research can help reduce the lag between discovery and delivery, including as new EBIs emerge, or as existing ones are adapted based on new research. Rwanda was the first low-income African country to implement the rotavirus vaccine (RTV) and also adopted
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Drivers of success: improving implementation research tools for better health outcomes BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Quinhas Fernandes, Orvalho Augusto, Kenneth Sherr
A thorough examination of context, and how it influences implementation of evidence-based interventions, is a promising strategy for enhancing child survival initiatives. Spreading approaches that are identified as drivers of successful reduction in under-five mortality from ‘exemplar’ countries could be pivotal in leading to reductions in other settings facing stagnant mortality rates, in particular
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Reducing the equity gap in under-5 mortality through an innovative community health program in Ethiopia: an implementation research study BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Laura Drown, Alemayehu Amberbir, Alula M. Teklu, Meseret Zelalem, Abreham Tariku, Yared Tadesse, Solomon Gebeyehu, Yirdachew Semu, Jovial Thomas Ntawukuriryayo, Amelia VanderZanden, Agnes Binagwaho, Lisa R. Hirschhorn
The Ethiopian government implemented a national community health program, the Health Extension Program (HEP), to provide community-based health services to address persisting access-related barriers to care using health extension workers (HEWs). We used implementation research to understand how Ethiopia leveraged the HEP to widely implement evidence-based interventions (EBIs) known to reduce under-5
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Lessons from Peru to reduce under-5 mortality: understanding program implementation and context BMC Pediatr. (IF 2.4) Pub Date : 2024-02-28 Patricia J. García, Anna Larson Williams, Marco H. Carcamo, Amelia VanderZanden, Agnes Binagwaho
Health policymakers aiming to reduce under-5 mortality (U5M) often lack data regarding how successful interventions in other countries were implemented. The Exemplars in U5M Study identified countries that achieved significant reductions in amenable U5M. This case study in Peru used implementation research to explore the contextual factors and strategies that contributed to the successful implementation