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Case Report: Comprehensive evaluation of ECG phenotypes and genotypes in a family with Brugada syndrome carrying SCN5A-R376H Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-15 Ngoc Bao Ly, Yoo Ri Kim, Ki Hong Lee, Namsik Yoon, Hyung Wook Park
BackgroundBrugada syndrome (BrS) is a channelopathy that can lead to sudden cardiac death in the absence of structural heart disease. Patients with BrS can be asymptomatic or present with symptoms secondary to polymorphic ventricular tachycardia or ventricular fibrillation. Even though BrS can exhibit autosomal dominant inheritance, it is not easy to identify the phenotype and genotype in a family
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Mendelian randomization of chronic hepatitis B and cardiovascular disease Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-15 Dongjie Wu, Feiyang Xiong, Qingzhi Ran, Jing Liu, Qingjuan Wu, Liang Wang, Wenliang Lv
BackgroundEvidence from observational studies suggests that chronic hepatitis B (CHB) is associated with cardiovascular disease (CVD). However, results have been inconsistent and causality remains to be established. We utilized two-sample Mendelian randomization (MR) to investigate potential causal associations between CHB and CVD, including atherosclerosis, coronary heart disease, hypertension, and
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Frozen elephant trunk versus conventional proximal repair of acute aortic dissection type I Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-15 Nora Göbel, Simone Holder, Franziska Hüther, Yasemin Anguelov, Dorothee Bail, Ulrich Franke
ObjectiveThe extent of surgery and the role of the frozen elephant trunk (FET) for surgical repair of acute aortic dissection type I are still subjects of debate. The aim of the study is to evaluate the short- and long-term results of acute surgical repair of aortic dissection type I using the FET compared to standard proximal aortic repair.MethodsBetween October 2009 and December 2016, 172 patients
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Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-15 Ahmed Elmahdy, Aaron Shekka Espinosa, Yalda Kakaei, Tetiana Pylova, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Amin Al-Awar, Zahra Sheybani, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Erik Axel Andersson, Elmir Omerovic, Shafaat Hussain, Björn Redfors
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after myocardial ischemia that recovers without permanent damage. The relationship between IPC and myocardial stunning remains incompletely understood.
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Case Report: Combined perioperative extracorporeal membrane oxygenation for acute heart failure caused by mitral regurgitation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-15 Brock Daughtry, John Richardson
Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS) devices are well-established adjunctive treatment measures for patients with heart failure. ECMO can serve as a bridge to transplant in a chronic setting or as a salvage therapy for patients who are unable to be weaned from bypass following cardiac surgery. However, the role of ECMO as a bridge to definitive therapy in
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Preoperative C-reactive protein/albumin ratio and mortality of off-pump coronary artery bypass graft Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-15 Ah Ran Oh, Ji-Hye Kwon, Jungchan Park, Jeong-Jin Min, Jong-Hwan Lee, Seung Yeon Yoo, Dong Jae Lee, Wooksung Kim, Hyun Sung Cho, Chung Su Kim, Sangmin Maria Lee
BackgroundWe sought to investigate the prognostic value of preoperative C-reactive protein (CRP)-to-albumin ratio (CAR) for the prediction of mortality in patients undergoing off-pump coronary artery bypass grafting (OPCAB).MethodsFrom January 2010 to August 2016, adult patients undergoing OPCAB were analyzed retrospectively. In a total of 2,082 patients, preoperative inflammatory markers including
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Prediction of ventilator weaning failure in postoperative cardiac surgery patients using vasoactive-ventilation-renal score and nomogram analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-14 Zhongqi Zhang, Wanchun Tang, Yankang Ren, Yifan Zhao, Jinjin You, Han Wang, Sheng Zhao, Xiangrong Zuo
ObjectiveThis study evaluated the predictive value of the vasoactive-ventilation-renal (VVR) score in identifying the risk of weaning failure after cardiac surgery and developing a nomogram model to help physicians improve the success rate of weaning from mechanical ventilation in adult patients undergoing postoperative cardiac surgery.MethodsClinical data were retrospectively collected from adult
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Decreased circulating omega-3 fatty acids increase the risk of myocardial infarction: a two-sample Mendelian randomization study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-14 Wei Wang, Linfei Yang, Jing Zhang, Haiyun Xiang
BackgroundMany studies have shown that omega-3 fatty acids may play critical roles in cardiovascular diseases. Myocardial infarction (MI) typically results from a thrombotic occlusion of a coronary artery leading to myocardial ischemia. Thus, this study aims to examine the association between omega-3 fatty acids and MI.MethodsA two-sample Mendelian randomization study was used to explore the causal
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Diabetic kidney disease as an independent predictor of long-term adverse outcomes in patients with coronary artery disease and diabetic mellitus Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-14 Zhiyu Liu, Rui Jiang, Ruochen Xu, Yunzhe Wang, Yan Lv, Chang Su, Fengyi Yu, Zhen Qin, JunNan Tang, JinYing Zhang
BackgroundDiabetic kidney disease (DKD) had been proposed as a contributor in the pathogenesis of coronary artery disease (CAD). However, the relationship of DKD and the long-term adverse outcomes in patients with CAD after percutaneous coronary intervention (PCI) was still undiscovered.MethodsApproximately 892 patients with CAD enrolled from January 2012 to December 2016. The patients were divided
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The “arrhythmic” presentation of peripartum cardiomyopathy: case series and critical review of the literature Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-14 Giovanni Peretto, Emanuele Micaglio, Giuseppe Ciconte, Marianna Maia, Martina Luzzi, Marianna Cariello, Adele Gabriella Rosa Bonfanti, Davide Lazzeroni, Luigi Anastasia, Paolo Cavoretto, Alaide Chieffo, Paolo Della Bella, Carlo Pappone
Peripartum Cardiomyopathy (PPCM) is a polymorphic myocardial disease occurring late during pregnancy or early after delivery. While reduced systolic function and heart failure (HF) symptoms have been widely described, there is still a lack of reports about the arrhythmic manifestations of the disease. Most importantly, a broad range of unidentified pre-existing conditions, which may be missed by general
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A contemporary training concept in critical care cardiology Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-14 Leonhard Binzenhöfer, Nils Gade, Daniel Roden, Inas Saleh, Hugo Lanz, Laura Villegas Sierra, Paula Seifert, Clemens Scherer, Benedikt Schrage, Franz Haertel, Peter M. Spieth, Norman Mangner, Christoph Adler, Daniel Hoyer, Tobias Graf, Hannah Billig, Mostafa Salem, Rafael Henrique Rangel, Walter S. Speidl, Christian Hagl, Jörg Hausleiter, Steffen Massberg, Michael Preusch, Benjamin Meder, David M. Leistner
Critical care cardiology (CCC) in the modern era is shaped by a multitude of innovative treatment options and an increasingly complex, ageing patient population. Generating high-quality evidence for novel interventions and devices in an intensive care setting is exceptionally challenging. As a result, formulating the best possible therapeutic approach continues to rely predominantly on expert opinion
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Best practices for vascular arterial access and closure: a contemporary guide for the cardiac catheterization laboratory Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-14 Moemen Eltelbany, Matteo Fabbri, Wayne B. Batchelor, Lindsey Cilia, Aaron Ducoffe, Kendall Endicott, Kelly Epps, Amika McBurnie, Richard Neville, Carolyn Rosner, Matthew W. Sherwood, David Spinosa, Alexander G. Truesdell, Cassandra Vorgang, Abdulla A. Damluji, Behnam N. Tehrani
More than 1 million transcatheter-based cardiovascular procedures across the spectrum of interventional cardiology are performed annually in the United States. With the expanded indications for and increased complexities associated with these procedures, interventional cardiologists are expected to possess the requisite expertise to complete these interventions safely and effectively. While the art
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Risk factors, prevention, and therapy of intraluminal stent thrombosis in frozen elephant trunk prostheses—what we know so far Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Florian Helms, Bastian Schmack, Alexander Weymann, Reza Poyanmehr, Andreas Martens, Jawad Salman, Alina Zubarevich, Jan D. Schmitto, Arjang Ruhparwar, Aron-Frederik Popov
Intraluminal thrombus formation (ILT) is a recently discovered and highly clinically relevant complication after frozen elephant trunk implantation in cardiovascular surgery. In this phenomenon, a thrombus forms within the lumen of the stent graft component of the frozen elephant trunk prosthesis and puts the patient at risk for downstream embolization with visceral or lower limb ischemia. Incidence
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Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Junyuan Yan, Xinqin Zhong, Yucui Zhao, Xiaoying Wang
The occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate CMEC injury and thus improve cardiovascular diseases. MiRNAs are a class of noncoding single-strand RNA
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Insulin resistance/hyperinsulinemia: an important cardiovascular risk factor that has long been underestimated Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Serafino Fazio, Valentina Mercurio, Loredana Tibullo, Valeria Fazio, Flora Affuso
Cardiovascular mortality is still excessively high, despite the considerable progress made in the prevention and treatment of cardiovascular diseases. Although many cardiovascular risk factors (such as arterial hypertension, hypercholesterolemia, diabetes, etc.), identified in the general population, are being promptly treated, to date little consideration is given to a cardiovascular risk factor which
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Construction of a nomogram risk prediction model for prolonged mechanical ventilation in patients following surgery for acute type A aortic dissection Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Yun Yu, Yan Wang, Fang Deng, Zhigang Wang, Beibei Shen, Ping Zhang, Zheyun Wang, Yunyan Su
BackgroundThis study aims to analyze the risk factors associated with prolonged mechanical ventilation (PMV) in patients following surgical treatment for acute type A aortic dissection (ATAAD). The objectives include constructing a predictive model for risk assessment and validating its predictive efficacy.MethodsA total of 452 patients diagnosed with ATAAD and undergoing surgical procedures at a tertiary
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Healthcare needs in elderly patients with chronic heart failure in view of a personalized blended collaborative care intervention: a cross sectional study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Sara Gostoli, Francesco Bernardini, Regina Subach, Petra Engelmann, Tiny Jaarsma, Frida Andréasson, Sanne Rasmussen, Trine Thilsing, Natasja Eilerskov, Barbara Bordoni, Diego Della Riva, Stefano Urbinati, Sebastian Kohlmann, Chiara Rafanelli
IntroductionFew studies explored healthcare needs of elderly heart failure (HF) patients with comorbidities in view of a personalized intervention conducted by Care Managers (CM) in the framework of Blended Collaborative Care (BCC). The aims of the present study were to: (1) identify perceived healthcare needs/preferences in elderly patients with HF prior to a CM intervention; (2) investigate possible
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Effect of statin add-on therapy on cardiovascular mortality Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 John R. Nelson, Viet Le, Jeffrey L. Anderson, Nicole Ciffone
IntroductionCardiovascular (CV) disease remains a leading cause of mortality despite statin therapy. Statin add-on lipid-lowering therapies have been investigated for CV risk reduction, but their effect on CV mortality has not been reviewed.MethodsThis review describes CV outcomes trials of add-on therapies to statins, highlighting findings related to the primary composite CV endpoints and the more
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Case Report: Heart aneurysm of unknown origin in a two-year-old child diagnosed in the course of Multisystem Inflammatory Syndrome in Children Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Dominika Mystkowska, Michal Galeczka, Wojciech Tarala, Pawel Banaszak, Joanna Sliwka, Szymon Pawlak, Roland Fiszer
We present a case of a 22-month-old boy with a hypokinetic and thin-walled aneurysm of the left ventricle apex. The lesion was diagnosed during routine echocardiography examination in the course of MIS-C, and its occurrence due to MIS-C is plausible. Cardiac magnetic resonance imaging revealed an akinetic aneurysm of the LV apex with a full-wall ischemic scar. Aortography confirmed a normal course
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Contemporary approach to cardiogenic shock care: a state-of-the-art review Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Aditya Mehta, Ilan Vavilin, Andrew H. Nguyen, Wayne B. Batchelor, Vanessa Blumer, Lindsey Cilia, Aditya Dewanjee, Mehul Desai, Shashank S. Desai, Michael C. Flanagan, Iyad N. Isseh, Jamie L. W. Kennedy, Katherine M. Klein, Hala Moukhachen, Mitchell A. Psotka, Anika Raja, Carolyn M. Rosner, Palak Shah, Daniel G. Tang, Alexander G. Truesdell, Behnam N. Tehrani, Shashank S. Sinha
Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through
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The Fbn1 gene variant governs passive ascending aortic mechanics in the mgΔlpn mouse model of Marfan syndrome when superimposed to perlecan haploinsufficiency Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Samar A. Tarraf, Rodrigo Barbosa de Souza, Ashley Herrick, Lygia V. Pereira, Chiara Bellini
IntroductionAscending thoracic aortic aneurysms arise from pathological tissue remodeling that leads to abnormal wall dilation and increases the risk of fatal dissection/rupture. Large variability in disease manifestations across family members who carry a causative genetic variant for thoracic aortic aneurysms suggests that genetic modifiers may exacerbate clinical outcomes. Decreased perlecan expression
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The impact of endovascular stents types on perioperative outcomes of ruptured abdominal aortic aneurysms: a single-center experience Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-13 Huibo Ma, Xueyi Wang, Yangshuo Liu, Yongxin Li, Mingjin Guo
IntroductionRuptured abdominal aortic aneurysm (rAAA) represents a critically urgent vascular surgical condition, and endovascular aneurysm repair (EVAR) is a clinically effective treatment option. This study aims to investigate whether the type of intravascular graft used for ruptured abdominal aortic aneurysms has an impact on perioperative outcomes of EVAR.MethodsA retrospective analysis was conducted
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Case Report: Neurological adverse events in subject with myasthenia gravis after PCSK9 inhibitor administration Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-12 Věra Adámková, Martina Vitásková, Jaroslav A. Hubáček
BackgroundMyasthenia gravis is a rare chronic autoimmune neuromuscular disorder mainly caused by autoantibodies to the nicotinic acetylcholine receptor. Cholesterol is an essential molecule that affects the distribution and proper functioning of this receptor. Several reports have described the potential worsening of myasthenia gravis in patients treated with statins.Case presentationThe patient was
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Study on the related factors of TCM constitution and hemodynamics in patients with coronary heart disease Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-11 Boyan Mao, Zhou Zhao, Minghui Wei, Xinzhu Liu, Ruoqi Zhao, Weipeng Zhang, Mengyao Duan
BackgroundThe concepts of “individualization” and “preventive treatment” should be incorporated into the precise diagnosis and treatment of coronary heart disease (CHD). Both hemodynamics and Chinese medicine constitution studies align with these two concepts.MethodsThis study utilized data from 81 patients with CHD, including 12 patients with balanced constitution (BC), 20 patients with blood stasis
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Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-11 Jia Wang, Wei Guo, Qiang Wang, Yongjian Yang, Xiongshan Sun
Belonging to a lipid phosphatase family containing 16 members, myotubularin-related proteins (MTMRs) are widely expressed in a variety of tissues and organs. MTMRs preferentially hydrolyzes phosphatidylinositol 3-monophosphate and phosphatidylinositol (3,5) bis-phosphate to generate phosphatidylinositol and phosphatidylinositol 5-monophosphate, respectively. These phosphoinositides (PIPs) promote membrane
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Estimation of aortic stiffness by finger photoplethysmography using enhanced pulse wave analysis and machine learning Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-11 Henrik Hellqvist, Mikael Karlsson, Johan Hoffman, Thomas Kahan, Jonas Spaak
IntroductionAortic stiffness plays a critical role in the evolution of cardiovascular diseases, but the assessment requires specialized equipment. Photoplethysmography (PPG) and single-lead electrocardiogram (ECG) are readily available in healthcare and wearable devices. We studied whether a brief PPG registration, alone or in combination with single-lead ECG, could be used to reliably estimate aortic
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Stress hyperglycemia and poor outcomes in patients with ST-elevation myocardial infarction: a systematic review and meta-analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-11 Abdul Hakim Alkatiri, Nurul Qalby, Idar Mappangara, Ahmad Taufik F. Zainal, Maarten J. Cramer, Pieter A. Doevendans, Andriany Qanitha
BackgroundHyperglycemia, characterized by elevated blood glucose levels, is frequently observed in patients with acute coronary syndrome, including ST-elevation myocardial infarction (STEMI). There are conflicting sources regarding the relationship between hyperglycemia and outcomes in STEMI patients. We aimed to compile evidence to assess the association between hyperglycemia and adverse outcomes
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Gender-specific genetic and epigenetic signatures in cardiovascular disease Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-11 Justin Bridges, Jose A. Ramirez-Guerrero, Manuel Rosa-Garrido
Cardiac sex differences represent a pertinent focus in pursuit of the long-awaited goal of personalized medicine. Despite evident disparities in the onset and progression of cardiac pathology between sexes, historical oversight has led to the neglect of gender-specific considerations in the treatment of patients. This oversight is attributed to a predominant focus on male samples and a lack of sex-based
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Case report of belt electrode-skeletal muscle electrical stimulation for acute heart failure with severe obesity: a novel therapeutic option for acute phase rehabilitation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-08 Yuto Mochizuki, Takahiro Jimba, Syota Yasukawa, Aritomo Katsura, Akira Fukuda, Jiro Ando
BackgroundBelt electrode skeletal muscle electrical stimulation (B-SES) is an emerging therapy anticipated to yield more favorable outcomes than conventional neuromuscular electrical stimulation (NMES), owing to its larger stimulation area. However, information on its efficacy and safety in patients with heart failure remains limited.Case presentationA 43-year-old man with a body mass index of 41 kg/m2
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Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-08 Takeru Sato, Takumi Aoki, Yuki Ito, Kan Oishi, Masaki Fujishima, Eri Okumura, Kojiro Ishii
BackgroundCardiac autonomic function (CAF) decreases with aging, and Acanthopanax senticosus Harms (ASH) consumption reportedly induces anti-stress effects. This study aimed to assess the effect of continuous supplementation of ASH on CAF during resting and standing tests in the elderly population.MethodsThis double-blind, randomized controlled trial was conducted in the morning in a laboratory setting
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Reduced mitochondrial pyruvate carrier expression in hearts with heart failure and reduced ejection fraction patients: ischemic vs. non-ischemic origin Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-08 Paula Lopez-Vazquez, Mariana Fernandez-Caggiano, Eduardo Barge-Caballero, Gonzalo Barge-Caballero, David Couto-Mallon, Zulaika Grille-Cancela, Paula Blanco-Canosa, Maria J. Paniagua-Martin, Daniel Enriquez-Vazquez, Jose M. Vazquez-Rodriguez, Nieves Domenech, Maria G. Crespo-Leiro
Introduction and objectivesMitochondrial pyruvate carrier (MPC) mediates the entry of pyruvate into mitochondria, determining whether pyruvate is incorporated into the Krebs cycle or metabolized in the cytosol. In heart failure (HF), a large amount of pyruvate is metabolized to lactate in the cytosol rather than being oxidized inside the mitochondria. Thus, MPC activity or expression might play a key
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Advanced detection of coronary artery disease via deep learning analysis of plasma cytokine data Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-08 Muhammad Shoaib, Ahmad Junaid, Ghassan Husnain, Mansoor Qadir, Yazeed Yasin Ghadi, S. S. Askar, Mohamed Abouhawwash
The 2017 World Health Organization Fact Sheet highlights that coronary artery disease is the leading cause of death globally, responsible for approximately 30% of all deaths. In this context, machine learning (ML) technology is crucial in identifying coronary artery disease, thereby saving lives. ML algorithms can potentially analyze complex patterns and correlations within medical data, enabling early
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Mendelian randomization supports genetic liability to hospitalization for COVID-19 as a risk factor of pre-eclampsia Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-08 Weizhen Wu, Junning Zhang, Yizhuo Qiao, Yuehan Ren, Xuezhi Rao, Zhijie Xu, Baoxing Liu
BackgroundPre-eclampsia and eclampsia are among the major threats to pregnant women and fetuses, but they can be mitigated by prevention and early screening. Existing observational research presents conflicting evidence regarding the causal effects of coronavirus disease 2019 (COVID-19) on pre-eclampsia risk. Through Mendelian randomization (MR), this study aims to investigate the causal effect of
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Establishment and evaluation of a nomogram for in-hospital new-onset atrial fibrillation after percutaneous coronary intervention for acute myocardial infarction Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Junjie Tu, Ziheng Ye, Yuren Cao, Mingming Xu, Shen Wang
Background New-onset atrial fibrillation (NOAF) is prognostic in acute myocardial infarction (AMI). The timely identification of high-risk patients is essential for clinicians to improve patient prognosis. Methods A total of 333 AMI patients were collected who underwent percutaneous coronary intervention (PCI) at Zhejiang Provincial People's Hospital between October 2019 and October 2020. Least absolute
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Integrative analysis of bioinformatics and machine learning to identify cuprotosis-related biomarkers and immunological characteristics in heart failure Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Dingyuan Tu, Qiang Xu, Yanmin Luan, Jie Sun, Xiaoli Zuo, Chaoqun Ma
Backgrounds Cuprotosis is a newly discovered programmed cell death by modulating tricarboxylic acid cycle. Emerging evidence showed that cuprotosis-related genes (CRGs) are implicated in the occurrence and progression of multiple diseases. However, the mechanism of cuprotosis in heart failure (HF) has not been investigated yet. Methods The HF microarray datasets GSE16499, GSE26887, GSE42955, GSE57338
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The ratio of systolic and diastolic pressure is associated with carotid and femoral atherosclerosis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Yuanping Wang, Cheng Chen, Qiaofen Lin, Qingling Su, Yiquan Dai, Hongyu Chen, Tianmin He, Xiantao Li, Ruimei Feng, Wuqing Huang, Zhijian Hu, Jun Chen, Shanshan Du, Pingfan Guo, Weimin Ye
BackgroundAlthough the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined. In addition, the role of the ratio of systolic and diastolic pressure (SDR) in the subclinical atherosclerosis (AS) risk remains unknown. We assessed the relationship between SDR and carotid and femoral
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Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Le-Kun Gui, Huang-Jun Liu, Li-Jun Jin, Xiao-Chun Peng
Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has led to the modification of definition and classification of cardiomyopathy. Herein, we reviewed seven of the most common types of cardiomyopathies
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Hybrid stage 1 palliation for HLHS: the experience of a tertiary center in a developing country Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Fouad Bitar, Issam M. El-Rassi, Rana Zareef, Yehya Jassar, Jennifer Abboud, Ziad Bulbul, Fadi Bitar, Mariam Arabi
BackgroundHypoplastic left heart syndrome (HLHS) accounts for 2.6% of congenital heart disease and is an invariably fatal cardiac anomaly if left untreated. Approximately 33,750 babies are born annually with HLHS in developing countries. Unfortunately, the majority will not survive due to the scarcity of resources and the limited availability of surgical management.AimTo describe and analyze our experience
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The heart-mind relationship in women cardiovascular primary prevention: the role of depression, anxiety, distress and Type-D personality in the 10-years cardiovascular risk evaluation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Mattia Giuliani, Giulia Santagostino Baldi, Nicolò Capra, Alice Bonomi, Chiara Marzorati, Valeria Sebri, Paolo Guiddi, Piero Montorsi, Gabriella Pravettoni, Daniela Trabattoni
IntroductionCardiovascular diseases are the leading cause of death among women. Prevention programmes underscore the need to address women-specific risk factors. Additionally, mental well-being is a significant aspect to consider when grappling with cardiovascular disease in women, particularly depression, anxiety, distress, and personality traits. This study aimed to create “at-risk” psychological
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Fractional flow reserve and instantaneous wave-free ratio in coronary artery bypass grafting: a meta-analysis and practice review Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 R. G. Abbasciano, G. R. Layton, S. Torre, N. Abbaker, A. Copperwheat, C. Lucarelli, S. Bhandari, S. Nijjer, G. Mikhail, R. Casula, M. Zakkar, A. Viviano
ObjectiveFractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are invasive methods to assess the functional significance of intermediate severity coronary lesions. Both indexes have been extensively validated in clinical trials in guiding revascularisation in patients with stable ischaemic heart disease undergoing percutaneous coronary intervention (PCI) with improved clinical outcomes
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Lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients in non-metropolitan area of Brandenburg, Germany Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-07 Philipp Hillmeister, Kangbo Li, Mengjun Dai, Mesud Sacirovic, Nikolaos Pagonas, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Claudia Zemmrich
Background and aimsIn the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates of cardiovascular diseases and underserved medical care, there is a lack of awareness regarding lipoprotein(a) [Lp(a)] as a risk factor. In addition, data from patients with atherosclerotic cardiovascular disease (ASCVD) in diverse regional backgrounds, including the understudied Brandenburg
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The molecular mechanism of thrombospondin family members in cardiovascular diseases Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-06 Heng Pan, Xiyi Lu, Di Ye, Yongqi Feng, Jun Wan, Jing Ye
Cardiovascular diseases have been identified as vital factors in global morbidity and mortality in recent years. The available evidence suggests that various cytokines and pathological proteins participate in these complicated and changeable diseases. The thrombospondin (TSP) family is a series of conserved, multidomain calcium-binding glycoproteins that cause cell-matrix and cell-cell effects via
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Case Report: Role of numerical simulations in the management of acute aortic syndromes Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-06 Antonio Rizza, Vincenzo Castiglione, Katia Capellini, Cataldo Palmieri, Emanuele Gasparotti, Sergio Berti, Simona Celi
Penetrating aortic ulcer (PAU) represents a subset of acute aortic syndromes characterized by high rupture risk and management challenges, particularly in elderly patients with significant comorbidities. This case report showcases a 75-year-old patient with a history of coronary artery bypass graft (CABG) and with multiple PAUs involving the aortic arch, deemed unfit for conventional open surgery.
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Prenatal transposition of great arteries diagnosis and management: a Chinese single-center study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-06 Jie Guo, Wen Ling, Tingting Dang, Shan Guo, Hong Ma, Qiong Huang, Liqin Zeng, Zongjie Weng, Qiumei Wu
ObjectiveThis study aimed to assess the diagnostic value of prenatal echocardiography for identifying transposition of the great arteries (TGA) during pregnancy and evaluating the associated outcomes.MethodsWe conducted a retrospective analysis of 121 prenatally diagnosed patients with TGA at our hospital between January 2012 and September 2022. This analysis included prenatal ultrasound, prenatal
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LGBTQ+ cardiovascular health equity: a brief review Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-06 Jason A. Bonomo, Kate Luo, Jorge A. Ramallo
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Data shows that social drivers of health (SDOH), including economic stability, racial/cultural identity, and community, have a significant impact on cardiovascular morbidity and mortality. LGBTQ+ (lesbian, gay, bisexual, transgender, queer, and other gender and sexual minority) patients face a variety
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Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-06 Eva Harlacher, Corinna Schulte, Sonja Vondenhoff, Philippe Schmitt-Kopplin, Philippe Diederich, Christian Hemmers, Julia Moellmann, Julia Wollenhaupt, Rogier Veltrop, Erik Biessen, Michael Lehrke, Björn Peters, Georg Schlieper, Christoph Kuppe, Jürgen Floege, Vera Jankowski, Nikolaus Marx, Joachim Jankowski, Heidi Noels
Chronic kidney disease (CKD) significantly increases cardiovascular risk and mortality, and the accumulation of uremic toxins in the circulation upon kidney failure contributes to this increased risk. We thus performed a screening for potential novel mediators of reduced cardiovascular health starting from dialysate obtained after hemodialysis of patients with CKD. The dialysate was gradually fractionated
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Advanced hemodynamics for prognostication in heart failure: the pursuit of the patient-specific tipping point Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-06 Jonathan Grinstein
BackgroundObjective tools to define the optimal time for referral for advanced therapies and to help guide escalation and de-escalation of support can improve management decisions and outcomes for patients with advanced heart failure. The current parameters have variable prognostic potential depending on the patient population being studied and often have arbitrary thresholds.MethodsHere, a mathematical
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Clinical significance of regional constructive and wasted work in patients receiving cardiac resynchronization therapy Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-05 Chun-Li Wang, Lung-Sheng Wu, Chia-Tung Wu, Yung-Hsin Yeh, Yu-Wen Cheng, Kun-Chi Yen, Yi-Hsin Chan, Chi Chuang, Chi-Tai Kuo, Pao-Hsien Chu
BackgroundPrevious studies have shown that global constructive work (CW) and wasted work (WW) predict response to cardiac resynchronization therapy (CRT). This study evaluated the predictive value of regional CW and WW for reverse remodeling and clinical outcomes after CRT.MethodsWe performed a prospective study involving 134 CRT candidates with left bundle branch block and left ventricular ejection
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Objective sleep characteristics and hypertension: a community-based cohort study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-05 Chunyong Chen, Bo Zhang, Jingjing Huang
ObjectiveThe link between sleep quality and hypertension risk is well-established. However, research on the specific dose-relationship between objective sleep characteristics and hypertension incidence remains limited. This study aims to explore the dose-relationship association between objective sleep characteristics and hypertension incidence.MethodsA community-based prospective cohort study design
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Case Report: A case of Kounis syndrome induced by iodine contrast agent during coronary angiography Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-05 Yangliu Sun, Jian Zhang
Kounis Syndrome (KS), a seldom-seen adverse reaction to iodine contrast agents, has an incidence that remains unclear. At present, there are no unified guidelines for managing KS either nationally or internationally. Ioversol, a new triiodinated hypotonic nonionic contrast agent, is commonly used in cardiovascular Computed Tomography (CT) and vascular imaging for diagnostic purposes. Its principal
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Severe COVID-19 and its cardiopulmonary effects 6 and 18 months after hospital discharge Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-05 J. H. Niebauer, A. Iscel, S. Schedl, C. Capelle, M. Kahr, S. Schamilow, J. Faltas, M. Srdits, R. Badr-Eslam, M. Lichtenauer, A. Zoufaly, R. Valenta, S. Hoffmann, S. Charwat-Resl, C. Krestan, W. Hitzl, C. Wenisch, D. Bonderman
IntroductionSARS-CoV-2 infection affects the cardiopulmonary system in the acute as well as long-term phase. The aim of the present study was to comprehensively assess symptoms and possible long-term impairments 6 and 18 months after hospitalization for severe COVID-19 infection.MethodsThis prospective registry included patients with PCR-confirmed COVID-19 infection requiring hospitalization. Follow-up
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Mechanisms of torsades de pointes: an update Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-05 Yukiomi Tsuji, Masatoshi Yamazaki, Masafumi Shimojo, Satoshi Yanagisawa, Yasuya Inden, Toyoaki Murohara
Torsades de Pointes (TdP) refers to a polymorphic ventricular tachycardia (VT) with undulating QRS axis that occurs in long QT syndrome (LQTS), although the term has been used to describe polymorphic ventricular tachyarrhythmias in which QT intervals are not prolonged, such as short-coupled variant of TdP currently known as short-coupled ventricular fibrillation (VF) and Brugada syndrome. Extensive
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Robotic mitral valve surgery Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-05 John Massey, Kenneth Palmer, Omar Al-Rawi, Owen Chambers, Tim Ridgway, Selvaraj Shanmuganathan, Gopal Soppa, Paul Modi
Totally endoscopic robotic mitral valve repair is the least invasive surgical therapy for mitral valve disease. Robotic mitral valve surgery demonstrates faster recovery with shorter hospital stays, less morbidity, and equivalent mortality and mid-term durability compared to sternotomy. In this review, we will explore the advantages and disadvantages of robotic mitral valve surgery and consider important
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Association of HbA1c and utilization of internal mammary arteries with wound infections in CABG Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 Tim Knochenhauer, Andreas Schaefer, Jens Brickwedel, Beate Reiter, Shiho Naito, Svante Zipfel, Yvonne Schneeberger, Hermann Reichenspurner, Bjoern Sill
Background Deep sternal wound infection (DSWI) remains a serious complication after coronary artery bypass grafting (CABG). We herein aimed to stratify diabetic patients who underwent CABG using bilateral internal mammary artery (BIMA) for levels of glycated hemoglobin A1C (HbA1c) and compare postoperative outcomes. Methods Between January 2010 and August 2020, 4,186 consecutive patients underwent
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AI-based preeclampsia detection and prediction with electrocardiogram data Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 Liam Butler, Fatma Gunturkun, Lokesh Chinthala, Ibrahim Karabayir, Mohammad S. Tootooni, Berna Bakir-Batu, Turgay Celik, Oguz Akbilgic, Robert L. Davis
IntroductionMore than 76,000 women die yearly from preeclampsia and hypertensive disorders of pregnancy. Early diagnosis and management of preeclampsia can improve outcomes for both mother and baby. In this study, we developed artificial intelligence models to detect and predict preeclampsia from electrocardiograms (ECGs) in point-of-care settings.MethodsTen-second 12-lead ECG data was obtained from
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Contemporary evaluation and treatment of tricuspid regurgitation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 Andrei Minciunescu, Abbas Emaminia
Valvular heart disease is a global health burden with substantial mortality. The left-sided valvular diseases have been extensively described using the robust treatment strategies available. By contrast, the right-sided diseases, particularly the tricuspid valve (TV) and associated regurgitation, still have much to be delineated. Worsening tricuspid regurgitation (TR) is associated with increased mortality;
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Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 N. Howden, K. Branch, P. Douglas, M. Gray, M. Budoff, M. Dewey, D. E. Newby, S. J. Nicholls, R. Blankstein, S. Fathieh, S. M. Grieve, G. A. Figtree
Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. There are numerous effective medications for modifying CAD but new pharmacologic therapies require increasingly large
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Effects of different rehabilitation modality on cardiopulmonary function in patients with acute coronary syndrome after revascularization Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 Wanping Chen, Yan Feng, Meili Yu, Zhaoguo Zhang, Jiahui Wu, Wenxian Liu, Wei Gu
ObjectiveTo investigate the effects of different rehabilitation modalities on cardiopulmonary function in patients with acute coronary syndrome after revascularization.MethodsTwo randomized controlled trials were conducted. All patients were stable for more than 48 h and less than 1 week after revascularization for acute coronary syndrome and were randomly assigned to Group A (home-based rehabilitation
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Role of low-density lipoprotein electronegativity and sexual dimorphism in contributing early ventricular tachyarrhythmias following ST-elevation myocardial infarction Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 Mei-Yao Wu, An-Sheng Lee, Yen-Nien Lin, Wei-Hsin Chung, Ke-Wei Chen, Chiung-Ray Lu, Yun-Fang Chen, Chia-Ming Chang, Wei-Chung Tsai, Yi-Tzone Shiao, Chu-Huang Chen, Kuan-Cheng Chang
BackgroundEarly ventricular tachycardia/fibrillation (VT/VF) in patients with ST-elevation myocardial infarction (STEMI) has higher morbidity and mortality. This study examines gender-differentiated risk factors and underlying mechanisms for early onset VT/VF in STEMI.MethodsWe analyzed data from 2,964 consecutive STEMI patients between January 1, 2008 and December 31, 2021. Early VT/VF was defined
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Predictors of atrial fibrillation detection in embolic stroke of undetermined source patients with implantable loop recorder Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-03-04 Lucio D’Anna, Roberta La Cava, Ashni Khetarpal, Abeer Karjikar, Ahmad Almohtadi, Michele Romoli, Matteo Foschi, Raffaele Ornello, Federico De Santis, Simona Sacco, Samir Abu-Rumeileh, Simone Lorenzut, Daisy Pavoni, Mariarosaria Valente, Giovanni Merlino, Soraia Almeida, Asha Barnard, Jianqun Guan, Soma Banerjee, Phang Boon Lim
BackgroundCovert atrial fibrillation (AF) is a predominant aetiology of embolic stroke of undetermined source (ESUS). Evidence suggested that AF is more frequently detected by implantable loop recorder (ILR) than by conventional monitoring. However, the predictive factors associated with occult AF detected using ILRs are not well established yet. In this study we aim to investigate the predictors of