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Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-03-12 James Dundas, Jonathon Leipsic, Timothy Fairbairn, Nicholas Ng, Vida Sussman, Ilana Guez, Rachael Rosenblatt, Lynne M. Hurwitz Koweek, Pamela S. Douglas, Mark Rabbat, Gianluca Pontone, Kavitha Chinnaiyan, Bernard de Bruyne, Jeroen J. Bax, Tetsuya Amano, Koen Nieman, Campbell Rogers, Hironori Kitabata, Niels P.R. Sand, Tomohiro Kawasaki, Sarah Mullen, Whitney Huey, Hitoshi Matsuo, Manesh R. Patel, Bjarne
Background:Luminal stenosis, computed tomography–derived fractional-flow reserve (FFRCT), and high-risk plaque features on coronary computed tomography angiography are all known to be associated with adverse clinical outcomes. The interactions between these variables, patient outcomes, and quantitative plaque volumes have not been previously described.Methods:Patients with coronary computed tomography
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Left Atrial Strain Predicts Subclinical Atrial Fibrillation Detected by Long-term Continuous Monitoring in Elderly High-Risk Individuals Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-03-05 Flemming Javier Olsen, Søren Zöga Diederichsen, Peter Godsk Jørgensen, Magnus T. Jensen, Anders Dahl, Nino Emanuel Landler, Claus Graff, Axel Brandes, Derk Krieger, Ketil Haugan, Lars Køber, Søren Højberg, Jesper Hastrup Svendsen, Tor Biering-Sørensen
BACKGROUND:Left atrial (LA) speckle tracking provides detailed information on atrial function. Its utility for predicting subclinical atrial fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring.METHODS:This was an echocardiographic substudy of the LOOP study, where elderly at risk of stroke
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Potential Effects of Mild Atrial Secondary Mitral Regurgitation in Patients With Isolated Atrial Fibrillation Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-28 Jun Akashi, Mai Iwataki, Yosuke Nabeshima, Takeshi Onoue, Atsushi Hayashi, Tetsuo Tanaga, Shun Nishino, Toshiyuki Kimura, Mitsuhiro Yano, Nozomi Watanabe, Yuki Tsuda, Masaru Araki, Yoshisato Shibata, Yosuke Nishimura, Yutaka Otsuji, Masaharu Kataoka
BACKGROUND:Patients with only moderate atrial secondary mitral regurgitation (asMR) frequently develop heart failure (HF). Mechanisms of HF with moderate asMR and the impact of mild asMR remain unclarified. Although mild/moderate primary mitral regurgitation is compensated by left ventricular (LV) dilatation, the LV is not dilated in asMR. We hypothesized that patients with mild asMR without LV dilatation
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Multimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-20 Renee P. Bullock-Palmer, Karen Flores Rosario, Pamela S. Douglas, Rebecca T. Hahn, Roberto M. Lang, Panithaya Chareonthaitawee, Monvadi B. Srichai, Karen G. Ordovas, Lauren A. Baldassarre, Melissa S. Burroughs, Cory S. Henderson, Pamela K. Woodard, Kathleen Pressoir, Madhav Swaminathan, Ron Blankstein, Melissa A. Daubert
Innovations in cardiac imaging have fundamentally advanced the understanding and treatment of cardiovascular disease. These advances in noninvasive cardiac imaging have also expanded the role of the cardiac imager and dramatically increased the demand for imagers who are cross-trained in multiple modalities. However, we hypothesize that there is significant variation in the availability of cardiac
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Meta-Analysis of Normal Reference Values for Right and Left Ventricular Quantification by Cardiovascular Magnetic Resonance Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-20 Yang Zhan, Matthias G. Friedrich, Nandini Dendukuri, Yang Lu, Michael Chetrit, Ian Schiller, Lawrence Joseph, Jaime L. Shaw, Michael L. Chuang, Johannes H. Riffel, Warren J. Manning, Jonathan Afilalo
BACKGROUND:Cardiovascular magnetic resonance (CMR) reference values are relied upon to accurately diagnose left ventricular (LV) and right ventricular (RV) pathologies. To date, reference values have been derived from modest sample sizes with limited patient diversity and attention to 1 but not both commonly used tracing techniques for papillary muscles and trabeculations. We sought to overcome these
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Sex-Specific Association Between Perivascular Inflammation and Plaque Vulnerability Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-20 Daisuke Kinoshita, Keishi Suzuki, Haruhito Yuki, Takayuki Niida, Daichi Fujimoto, Yoshiyasu Minami, Damini Dey, Hang Lee, Iris McNulty, Junya Ako, Maros Ferencik, Tsunekazu Kakuta, Ik-Kyung Jang
BACKGROUND:It is not known whether there is a sex difference in the association between perivascular inflammation and plaque vulnerability. The aim of this study was to investigate the sex-specific association between perivascular inflammation and plaque vulnerability.METHODS:Patients who underwent coronary computed tomography angiography and optical coherence tomography were enrolled. All images were
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Closing the Last Mile Gap in Access to Multimodality Imaging in Rural Settings: Design of the Imaging Core of the Risk Underlying Rural Areas Longitudinal Study Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-20 Hooman Fazlalizadeh, Muhammad Shahzeb Khan, Ervin R. Fox, Pamela S. Douglas, David Adams, Michael J. Blaha, Melissa A. Daubert, Gary Dunn, Edwin van den Heuvel, Michelle D. Kelsey, Randolph P. Martin, James D. Thomas, Yngvil Thomas, Suzanne E. Judd, Ramachandran S. Vasan, Matthew J. Budoff, Gerald S. Bloomfield
Achieving optimal cardiovascular health in rural populations can be challenging for several reasons including decreased access to care with limited availability of imaging modalities, specialist physicians, and other important health care team members. Therefore, innovative solutions are needed to optimize health care and address cardiovascular health disparities in rural areas. Mobile examination
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Machine Learning and Bias in Medical Imaging: Opportunities and Challenges Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-20 Amey Vrudhula, Alan C. Kwan, David Ouyang, Susan Cheng
Bias in health care has been well documented and results in disparate and worsened outcomes for at-risk groups. Medical imaging plays a critical role in facilitating patient diagnoses but involves multiple sources of bias including factors related to access to imaging modalities, acquisition of images, and assessment (ie, interpretation) of imaging data. Machine learning (ML) applied to diagnostic
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Sex Differences in Coronary Inflammation and Atherosclerosis Phenotypes in Response to Imaging Marker of Stress-Related Neural Activity Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2024-02-20 Neng Dai, Xianglin Tang, Xinyu Weng, Haidong Cai, Jianhui Zhuang, Guangjie Yang, Fan Zhou, Ping Wu, Bao Liu, Shaofeng Duan, Yongfu Yu, Weifeng Guo, Zhiguo Ju, Longjiang Zhang, Zhenguang Wang, Yuetao Wang, Bin Lu, Hongcheng Shi, Juying Qian, Junbo Ge
BACKGROUND:Sex-specific differences in coronary phenotypes in response to stress have not been elucidated. This study investigated the sex-specific differences in the coronary computed tomography angiography-assessed coronary response to mental stress.METHODS:This retrospective study included patients with coronary artery disease and without cancer who underwent resting 18F-fluorodexoyglucose positron
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Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease Due to Coronary Embolism Clarified by Cardiac Computed Tomography. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-30 Shu Yoshihara,Masaki Matsunaga,Taku Yaegashi,Sadanori Nozue,Masaaki Naito
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Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-21 Xinghao Xu,Zhaoyan Wang,Rihua Huang,Yue Guo,Zhenyu Xiong,Xiaodong Zhuang,Xinxue Liao
BACKGROUND Recent studies have shown that remnant cholesterol (RC) is associated with incident heart failure; however, its association with left ventricular (LV) structure and function is unclear. We aimed to evaluate the association between RC levels in young adulthood and LV structure and function in middle age. METHODS We included 3321 participants from the CARDIA study (Coronary Artery Risk Development
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Remnant Cholesterol-A Novel Risk Marker for Left Ventricular Remodeling and Dysfunction. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-21 Benjamin Nilsson Wadström,Hashmat Sayed Zohori Bahrami
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Pericardial Late Gadolinium Enhancement After Cardiac Surgery: Defining Disease Begins With Understanding Normal. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-21 Mohamed Al-Kazaz,Paul C Cremer
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Coronary Computed Tomography Angiography Versus Invasive Coronary Angiography in Stable Chest Pain: A Meta-Analysis of Randomized Controlled Trials. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-21 Marina F Machado,Nicole Felix,Pedro H C Melo,Mateus M Gauza,Pedro Calomeni,Giuliano Generoso,Sourabh Khatri,Stephan Altmayer,Ron Blankstein,Marcio Sommer Bittencourt,Rhanderson Cardoso
BACKGROUND The efficacy of coronary computed tomography angiography (CCTA) versus invasive coronary angiography (ICA) among patients with stable chest pain has been studied in several trials with conflicting results. METHODS We performed a systematic review and meta-analysis comparing CCTA first versus direct ICA among patients with stable chest pain, who were initially referred to ICA. PubMed, EMBASE
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Artificial Intelligence to Speed Up Training in Echocardiography: The Next Frontier. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-13 Maria Chiara Meucci,Victoria Delgado
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Real-Time Artificial Intelligence-Based Guidance of Echocardiographic Imaging by Novices: Image Quality and Suitability for Diagnostic Interpretation and Quantitative Analysis. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-13 Victor Mor-Avi,Bijoy Khandheria,Robert Klempfner,Juan I Cotella,Merav Moreno,Denise Ignatowski,Brittney Guile,Hailee J Hayes,Kyle Hipke,Abigail Kaminski,Dan Spiegelstein,Noa Avisar,Itay Kezurer,Asaf Mazursky,Ran Handel,Yotam Peleg,Shir Avraham,Achiau Ludomirsky,Roberto M Lang
BACKGROUND We aimed to assess in a prospective multicenter study the quality of echocardiographic exams performed by inexperienced users guided by a new artificial intelligence software and evaluate their suitability for diagnostic interpretation of basic cardiac pathology and quantitative analysis of cardiac chamber and function. METHODS The software (UltraSight, Ltd) was embedded into a handheld
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Recovery of Tricuspid Valve Function After Resection of a Primary Ovarian Carcinoid Tumor. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-10 Jeffrey D Wong,Sarah J Finlayson,Jonathan Loree,Lynn Straatman,Parvathy Nair,Michael Y C Tsang,Christina L Luong,Teresa S M Tsang,Kenneth Gin,John Jue,Darwin F Yeung
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State-of-the-Art Imaging of Infiltrative Cardiomyopathies: A Scientific Statement From the American Heart Association. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-11-02 Anupama Kottam,Kate Hanneman,Aldo Schenone,Melissa A Daubert,Gursukhman Deep Sidhu,Robert J Gropler,Mario J Garcia,
Infiltrative cardiomyopathies comprise a broad spectrum of inherited or acquired conditions caused by deposition of abnormal substances within the myocardium. Increased wall thickness, inflammation, microvascular dysfunction, and fibrosis are the common pathological processes that lead to abnormal myocardial filling, chamber dilation, and disruption of conduction system. Advanced disease presents as
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Apical Aneurysm Development in Hypertrophic Cardiomyopathy. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-31 Manhal Habib,Sara Hoss,Arnon Adler,Olga Katz,Hadeel Halloun Habib,Kimia Fardfini,Harry Rakowski,Raymond H Chan
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Letter by Chen and Liang Regarding Article, "Impact of Diabetes on Myocardial Fibrosis in Patients With Hypertension: The REMODEL Study". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-26 Jun-Zhang Chen,Bo Liang
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Response by Pua et al to Letter Regarding Article, "Impact of Diabetes on Myocardial Fibrosis in Patients With Hypertension: The REMODEL Study". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-26 Chee Jian Pua,Thu-Thao Le,Calvin W L Chin
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Letter by Velders et al Regarding Article "Predictors of Major Adverse Cardiovascular Events in Patients With Moderate Aortic Stenosis: Implications for Aortic Valve Replacement". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-25 Bart J J Velders,Michiel D Vriesendorp,Rolf H H Groenwold
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Response by Majmundar et al to Letter Regarding Article, "Predictors of Major Adverse Cardiovascular Events in Patients With Moderate Aortic Stenosis: Implications for Aortic Valve Replacement". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-25 Monil Majmundar,Larisa G Tereshchenko,Travis Howard,Samir R Kapadia,Rishi Puri,Ankur Kalra
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Coronary Sinus Aneurysm With a Sinoventricular Valve. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-23 Nao Sasaki,Stephen P Sanders,Tal Geva,Sunil J Ghelani
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Role of Cardiac Energetics in Aortic Stenosis Disease Progression: Identifying the High-risk Metabolic Phenotype. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-17 Shveta Monga,Ladislav Valkovič,Saul G Myerson,Stefan Neubauer,Masliza Mahmod,Oliver J Rider
BACKGROUND Severe aortic stenosis (AS) is associated with left ventricular (LV) hypertrophy and cardiac metabolic alterations with evidence of steatosis and impaired myocardial energetics. Despite this common phenotype, there is an unexplained and wide individual heterogeneity in the degree of hypertrophy and progression to myocardial fibrosis and heart failure. We sought to determine whether the cardiac
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Metabolic Dysfunction in Aortic Stenosis: A Key Piece of the Pathophysiological Puzzle. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-17 David E Sosnovik,Sammy Elmariah
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Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-17 David T Gamble,James Ross,Hilal Khan,Andreas Unger,Lesley Cheyne,Amelia Rudd,Fiona Saunders,Janaki Srivanasan,Sylvia Kamya,Graham Horgan,Andrew Hannah,Santosh Baliga,Carlo Gabriele Tocchetti,Gordon Urquhart,Wolfgang A Linke,Yazan Masannat,Ahmed Mustafa,Mairi Fuller,Beatrix Elsberger,Ravi Sharma,Dana Dawson
BACKGROUND Anthracycline-related cardiac toxicity is a recognized consequence of cancer therapies. We assess resting cardiac and skeletal muscle energetics and myocyte, sarcomere, and mitochondrial integrity in patients with breast cancer receiving epirubicin. METHODS In a prospective, mechanistic, observational, longitudinal study, we investigated chemotherapy-naive patients with breast cancer receiving
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Beware Before Mitral Balloon Valvuloplasty: Parachute Mitral Valve Can Mimic Rheumatic Mitral Stenosis. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-10 Sarah Goldman,Hartzell Schaff,Kimberly Capustin,Annapoorna Kini,Samin Sharma,David Power,Waqas Malick,Jose Meller,Steve Liao,Lori Croft,Martin Goldman
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Response by Chong et al to Letter Regarding Article, "Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-analysis". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-06 Bryan Chong,Yip Han Chin,Nicholas W S Chew
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Letter by Aldous et al Regarding Article, "Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-analysis". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-06 Emma Aldous,Andrew Lin,Nitesh Nerlekar
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Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-06 R Glenn Wells,Frank M Bengel,Luca Camoni,Elisabetta Cerudelli,Sarah G Cuddy-Walsh,Johanna Diekmann,Lewis Han,Yoshito Kadoya,Naoto Kawaguchi,Yung Jih Felix Keng,Masao Miyagawa,Hagit Ratner,Xue Fen Teng,Terrence D Ruddy
BACKGROUND Single-center studies have shown that single photon emission computed tomography myocardial blood flow (MBF) measurement is accurate compared with MBF measured with microspheres in a porcine model, positron emission tomography, and angiography. Clinical implementation requires consistency across multiple sites. The study goal is to determine the intersite processing repeatability of single
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Intermediate Accessory Papillary Muscle: An Anatomic Variant of Interest for Transcatheter Edge-to-Edge Mitral Valve Repair. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-05 Takanori Sato,Issam D Moussa,Peter Hanna,Kalyanam Shivkumar,Shumpei Mori
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Atrial Myopathy Quantified by Speckle-tracking Echocardiography in Mice. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-05 Michael J Zhang,Dylan J Gyberg,Chastity L Healy,Naixin Zhang,Hong Liu,Samuel C Dudley,Timothy D O'Connell
BACKGROUND Emerging evidence suggests that atrial myopathy may be the underlying pathophysiology that explains adverse cardiovascular outcomes in heart failure (HF) and atrial fibrillation. Lower left atrial (LA) function (strain) is a key biomarker of atrial myopathy, but murine LA strain has not been described, thus limiting translational investigation. Therefore, the objective of this study was
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Opportunities and Challenges of Murine Atrial Strain Imaging. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-10-05 Jonathan R Lindner
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Coronary Atherosclerosis Across the Glycemic Spectrum Among Asymptomatic Adults: The Miami Heart Study at Baptist Health South Florida. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-29 Kershaw V Patel,Matthew J Budoff,Javier Valero-Elizondo,Shubham Lahan,Shozab S Ali,Mohamad B Taha,Michael J Blaha,Ron Blankstein,Michael D Shapiro,Ambarish Pandey,Lara Arias,Theodore Feldman,Ricardo C Cury,Miguel Cainzos-Achirica,Svati H Shah,Jack A Ziffer,Jonathan Fialkow,Khurram Nasir
BACKGROUND The contemporary burden and characteristics of coronary atherosclerosis, assessed using coronary computed tomography angiography (CCTA), is unknown among asymptomatic adults with diabetes and prediabetes in the United States. The pooled cohort equations and coronary artery calcium (CAC) score stratify atherosclerotic cardiovascular disease risk, but their association with CCTA findings across
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Routine Coronary Atherosclerosis Imaging in the Cardiovascular Risk Assessment of Prediabetes and Diabetes. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-29 Thiago Bosco Mendes,Marcio Sommer Bittencourt
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Long-term Consequence of Mediastinal Radiation Therapy for Thymoma on Cardiovascular System Confirmed by Cardiovascular Imaging. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-29 Hana Mizutani,Naoki Fujimoto,Kazushi Saihara,Masaki Ishida,Hajime Sakuma,Kaoru Dohi
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Rapid Improvement of Coronary Endothelial Function With PCSK9 Inhibition in People With HIV Is Associated With Reduced Lipoprotein (a) and Not LDL-cholesterol. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-29 Tarek Harb,Efthymios Ziogos,Michael Schär,Todd T Brown,Shenghan Lai,Gary Gerstenblith,Allison G Hays,Thorsten M Leucker
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Diagnosis of Acute Cholecystitis Using T1 and T2 Mapping by Cardiac MRI. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-22 Gautam Sen,Kristopher Knott,Stefania Rosmini
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Response by Loube et al to Letter Regarding Article "Stroke Caused by a Paradoxical Embolus From a Rare Congenital Anomaly in the Adult: Persistent Left Superior Vena Cava Draining Into the Left Upper Pulmonary Vein". Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-19 Deanne Kennedy Loube,Anirudh Sreekrishnan,Jennifer P Woo,Jody Shen,R Thomas Collins,Neil Schwartz
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Development and Validation of CCTA-based Radiomics Signature for Predicting Coronary Plaques With Rapid Progression. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-19 Qian Chen,Guanghui Xie,Chun Xiang Tang,Liu Yang,Pengpeng Xu,Xiaofei Gao,Mengjie Lu,Yunlei Fu,Yingsong Huo,Shaoqing Zheng,Xinwei Tao,Hui Xu,Xindao Yin,Long Jiang Zhang
BACKGROUND Rapid plaque progression (RPP) is associated with a higher risk of acute coronary syndromes compared with gradual plaque progression. We aimed to develop and validate a coronary computed tomography angiography (CCTA)-based radiomics signature (RS) of plaques for predicting RPP. METHODS A total of 214 patients who underwent serial CCTA examinations from 2 tertiary hospitals (development group
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Comparison of CT-derived Plaque Characteristic Index With CMR Perfusion for Ischemia Diagnosis in Stable CAD. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-19 Wei-Feng Guo,Hai-Jia Xu,Yi-Ge Lu,Guan-Yu Qiao,Shan Yang,Shi-Hai Zhao,Hang Jin,Neng Dai,Zhi-Feng Yao,Jia-Sheng Yin,Chen-Guang Li,Wei He,Mengsu Zeng
BACKGROUND Coronary computed tomography angiography (CCTA) and cardiac magnetic resonance (CMR) have been used to diagnose lesion-specific ischemia in patients with coronary artery disease. The aim of this study was to investigate the diagnostic performance of CCTA-derived plaque characteristic index compared with myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) derived from CMR perfusion
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Cardiovascular Molecular Imaging With Fluorine-19 MRI: The Road to the Clinic. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-19 Ruud B van Heeswijk,Wolfgang R Bauer,Florian Bönner,Jelena M Janjic,Willem J M Mulder,Laura M Schreiber,Juerg Schwitter,Ulrich Flögel
Fluorine-19 (19F) magnetic resonance imaging is a unique quantitative molecular imaging modality that makes use of an injectable fluorine-containing tracer that generates the only visible 19F signal in the body. This hot spot imaging technique has recently been used to characterize a wide array of cardiovascular diseases and seen a broad range of technical improvements. Concurrently, its potential
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Heart of the Matter: Expanding the Applicability of CAC to a More Diverse Population. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-01 Melissa A Daubert,Martha Gulati
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Feasibility of Simultaneous Quantification of Myocardial and Renal Perfusion With Cardiac Positron Emission Tomography. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-01 Jenifer M Brown,Mi-Ae Park,Marie Foley Kijewski,Brittany N Weber,Yihe Yang,Laurel Martell,Anna Perillo,Leanne Barrett,Sean Parks,Jon Hainer,Sharmila Dorbala,Ron Blankstein,Marcelo F Di Carli
BACKGROUND Given the central importance of cardiorenal interactions, mechanistic tools for evaluating cardiorenal physiology are needed. In the heart and kidneys, shared pathways of neurohormonal activation, hypertension, and vascular and interstitial fibrosis implicate the relevance of systemic vascular health. The availability of a long axial field of view positron emission tomography (PET)/computed
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Defining Demographic-specific Coronary Artery Calcium Percentiles in the Population Aged ≥75: The ARIC Study and MESA. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-09-01 Frances M Wang,Miguel Cainzos-Achirica,Shoshana H Ballew,Josef Coresh,Aaron R Folsom,Candace M Howard,Wendy S Post,Lynne E Wagenknecht,Matthew J Budoff,Michael J Blaha,Kunihiro Matsushita
BACKGROUND Current clinical guidelines recommend a coronary artery calcium (CAC) score of 100 Agatston Units or demographic-specific 75th percentile as high-risk thresholds for guiding atherosclerotic cardiovascular disease preventive therapy. Meanwhile, low CAC can help derisk individuals who may safely defer statin therapy. However, limited data from the early 2000s, including just 208 older Black
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Prognostic Value of Cardiac Magnetic Resonance Imaging in Patients With a Working Diagnosis of MINOCA-An Outcome Study With up to 10 Years of Follow-Up. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-08-15 Regina E Konst,Michele Parker,Lubna Bhatti,Yodying Kaolawanich,Fawaz Alenezi,Suzette E Elias-Smale,Robin Nijveldt,Raymond J Kim
BACKGROUND Patients with a working diagnosis of myocardial infarction with unobstructed coronary arteries (MINOCA) represent a heterogeneous cohort. The prognosis could vary substantially depending on the underlying cause. Although cardiac magnetic resonance (CMR) is considered a key diagnostic tool in these patients, there are limited data linking the CMR diagnosis with the outcome. METHODS This study
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Gamechanger: Diagnostic and Prognostic Value of Cardiovascular Magnetic Resonance in MINOCA. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-08-15 Erik B Schelbert,Yaron Fridman
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Interplay Between Zero CAC, Quantitative Plaque Analysis, and Adverse Events in a Diverse Patient Cohort. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-08-10 Michael Fattouh,Toshiki Kuno,Pamela Pina,John P Skendelas,Daniel Lorenzatti,Javier Arce,Jonathan Daich,Gustavo Duarte,Carol Fernandez-Hazim,Miguel Rodriguez-Guerra,Patrick Neshiwat,Aldo L Schenone,Lili Zhang,Carlos J Rodriguez,Armin Arbab-Zadeh,Piotr J Slomka,Salim S Virani,Michael J Blaha,Daniel S Berman,Damini Dey,Mario J Garcia,Leandro Slipczuk
BACKGROUND Coronary artery calcium scoring (CAC) has garnered attention in the diagnostic approach to chest pain patients. However, little is known about the interplay between zero CAC, sex, race, ethnicity, and quantitative coronary plaque analysis. METHODS We conducted a retrospective analysis from our computed tomography registry of patients with stable angina without prior myocardial infarction
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Myocardial Flow Reserve, an Independent Prognostic Marker of All-Cause Mortality Assessed by 82Rb PET Myocardial Perfusion Imaging: A Danish Multicenter Study. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-08-02 Signe Højstrup,Kim W Hansen,Ulrik Talleruphuus,Lisbeth Marner,Louise Bjerking,Lars Jakobsen,Evald H Christiansen,Kirsten Bouchelouche,Niels Wiinberg,Kasper Guldbrandsen,Søren Galatius,Eva Prescott
BACKGROUND Rubidium-82 positron emission tomography (82Rb PET) myocardial perfusion imaging is used in clinical practice to quantify regional perfusion defects. Additionally, 82Rb PET provides a measure of absolute myocardial flow reserve (MFR), describing the vasculature state of health. We assessed whether 82Rb PET-derived MFR is associated with all-cause mortality independently of the extent of
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Noninvasive Assessment of Lipomatous Metaplasia as a Substrate for Ventricular Tachycardia in Chronic Infarct. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-08-01 Lingyu Xu,Benoit Desjardins,Walter R Witschey,Saman Nazarian
Myocardial lipomatous metaplasia (LM) has been increasingly reported in patients with prior myocardial infarction. Cardiac magnetic resonance and cardiac contrast-enhanced computed tomography have been used to noninvasively detect and quantify myocardial LM in postinfarct patients, and may provide useful information for understanding cardiac mechanics, arrhythmia susceptibility, and prognosis. This
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Prognostic Power of Quantitative Assessment of Functional Mitral Regurgitation and Myocardial Scar Quantification by Cardiac Magnetic Resonance. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-28 Tom Kai Ming Wang,Duygu Kocyigit,Harry Choi,Chris M Anthony,Nicholas Chan,Jennifer Bullen,Zoran B Popović,Samir R Kapadia,Amar Krishnaswamy,Brian P Griffin,Scott D Flamm,W H Wilson Tang,Deborah H Kwon
BACKGROUND The severity classification of functional mitral regurgitation (FMR) remains controversial despite adverse prognosis and rapidly evolving interventions. Furthermore, it is unclear if quantitative assessment with cardiac magnetic resonance can provide incremental risk stratification for patients with ischemic cardiomyopathy (ICM) or non-ICM (NICM) in terms of FMR and late gadolinium enhancement
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Sex Differences in Coronary Atherosclerotic Phenotype and Healing Pattern on Optical Coherence Tomography Imaging. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-28 Lena Marie Seegers,Doreen DeFaria Yeh,Taishi Yonetsu,Tomoyo Sugiyama,Yoshiyasu Minami,Tsunenari Soeda,Makoto Araki,Akihiro Nakajima,Haruhito Yuki,Daisuke Kinoshita,Keishi Suzuki,Takayuki Niida,Hang Lee,Iris McNulty,Sunao Nakamura,Tsunekazu Kakuta,Valentin Fuster,Ik-Kyung Jang
BACKGROUND Layered plaque, a signature of previous plaque disruption, is a known predictor of rapid plaque progression. Layered plaque can be identified in vivo by optical coherence tomography. Studies have reported differences in plaque burden between women and men, but sex differences in the pattern of layered plaque are unknown. METHODS Preintervention optical coherence tomography images of 533
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Unraveling Sex Differences in Layered Plaque in Chronic Coronary Syndromes. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-28 Allison G Hays,Leslie Cho
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Muscle Matters: CMR Tissue Characterization for Mechanistically Tailored Risk Stratification of Functional Mitral Regurgitation. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-28 Jiwon Kim,Pablo Villar Calle,Jonathan W Weinsaft
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Treatment of Purulent Pericarditis With Intrapericardial Alteplase. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-21 Robert S Zhang,Arushi Singh,Usman Alam,Kelsey Grossman,Norma Keller,Carlos L Alviar,Sripal Bangalore
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Diagnostic Performance and Safety of a Novel Ferumoxytol-Enhanced Coronary Magnetic Resonance Angiography. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-18 Zhou Dong,Guangxiang Si,Xiaomei Zhu,Chen Li,Rui Hua,Jianzhen Teng,Wenhao Zhang,Lulu Xu,Wen Qian,Bo Liu,Jun Wang,Tong Wang,Yingdan Tang,Yang Zhao,Xiaoxuan Gong,Zhiwen Tao,Zhihui Xu,Yong Li,Bo Chen,Xiangqing Kong,Yi Xu,Ning Gu,Chunjian Li
BACKGROUND Currently, noninvasive arteriography for the diagnosis of coronary artery disease is clinically limited to the computed tomography scanning, where patients have to be exposed to the radiation and risks associated with iodinated contrast. We aimed to investigate the diagnostic performance and safety of a novel ferumoxytol-enhanced coronary magnetic resonance angiography (CMRA) in patients
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Rare Forms of Cardiac Amyloidosis: Diagnostic Clues and Phenotype in Apo AI and AIV Amyloidosis. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-11 Adam Ioannou,Aldostefano Porcari,Rishi K Patel,Yousuf Razvi,Giulio Sinigiani,Ana Martinez-Naharro,Lucia Venneri,James Moon,Muhammad U Rauf,Helen Lachmann,Ashutosh Wechelakar,Philip N Hawkins,Julian D Gillmore,Marianna Fontana
BACKGROUND Apo AI amyloidosis (AApoAI) and Apo AIV amyloidosis (AApoAIV) are rare but increasingly recognized causes of cardiac amyloidosis (CA). We sought to define the cardiac phenotype in AApoAI and AApoAIV using multimodality imaging. METHODS We identified all patients with AApoAI and AApoAIV assessed at our center between 2000 and 2021, and 2 cohorts of patients with immunoglobulin light-chain
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Early Appearance of Myocardial Fibrosis in Restrictive Diabetic Cardiomyopathy. Circ. Cardiovasc. Imaging (IF 7.5) Pub Date : 2023-07-11 Walter J Paulus